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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:gold coordination entity
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Accession:CHEBI:33971 term browser browse the term
Synonyms:related_synonym: gold coordination compounds;   gold coordination entities



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auranofin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Auranofin analog binds to ALB protein CTD PMID:16791640 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Bak1 BCL2-antagonist/killer 1 multiple interactions
increases response to substance
ISO [BAX co-treated with BAK1] results in increased susceptibility to Auranofin; BAK1 mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAK1 results in increased susceptibility to Auranofin
CTD PMID:18789312 PMID:21172426 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases response to substance
ISO [BAX co-treated with BAK1] results in increased susceptibility to Auranofin; BAX mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAX results in increased susceptibility to Auranofin
CTD PMID:18789312 PMID:21172426 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO BCL2 protein inhibits the reaction [Auranofin results in increased activity of CASP3 protein] CTD PMID:18789312 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO
EXP
Auranofin promotes the reaction [TNF protein results in increased activity of CASP3 protein]; Auranofin results in decreased expression of and results in increased cleavage of CASP3 protein; BCL2 protein inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAK1 mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]; BAX mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
CTD PMID:15159275 PMID:15191400 PMID:18789312 PMID:20542334 PMID:21699084 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Auranofin results in decreased expression of and results in increased cleavage of CASP8 protein CTD PMID:20542334 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Auranofin results in decreased expression of and results in increased cleavage of CASP9 protein CTD PMID:20542334 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Auranofin results in increased expression of CDKN1A protein CTD PMID:20542334 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpe CCAAT/enhancer binding protein epsilon multiple interactions ISO [Auranofin co-treated with Tretinoin] results in increased expression of CEBPE protein CTD PMID:15159275 NCBI chr15:28,169,885...28,171,283
Ensembl chr15:28,169,704...28,171,814
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Auranofin inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CHUK protein]; Auranofin inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]
Auranofin inhibits the reaction [TNF protein results in increased activity of CHUK protein]
CTD PMID:10820281 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Auranofin results in decreased activity of DIO1 protein CTD PMID:34662569 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions
increases expression
ISO [Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Auranofin results in increased expression of GPX1 protein]; Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein] CTD PMID:21355852 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO Auranofin results in increased expression of HMOX1 mRNA
Auranofin results in increased expression of HMOX1 mRNA; Auranofin results in increased expression of HMOX1 protein
CTD PMID:22008538 PMID:23942037 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Auranofin inhibits the reaction [IL1B protein affects the localization of RELA protein]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein] CTD PMID:10594346 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of IL6ST protein; [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of JAK2 protein; [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of STAT3 protein CTD PMID:20542334 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Il6st interleukin 6 cytokine family signal transducer multiple interactions ISO [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of IL6ST protein CTD PMID:20542334 NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
JBrowse link
G Irak1 interleukin-1 receptor-associated kinase 1 multiple interactions ISO Auranofin inhibits the reaction [lipopolysaccharide A results in increased degradation of IRAK1 protein] CTD PMID:17034761 NCBI chr  X:151,768,621...151,778,521
Ensembl chr  X:151,768,777...151,778,521
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO Auranofin inhibits the reaction [lipopolysaccharide A results in increased activity of IRF3 protein]; Auranofin inhibits the reaction [lipopolysaccharide A results in increased phosphorylation of IRF3 protein]; Auranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]; Auranofin inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein] CTD PMID:17034761 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO [Auranofin co-treated with Tretinoin] results in increased expression of ITGAM protein CTD PMID:15159275 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of JAK2 protein CTD PMID:20542334 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions
decreases expression
ISO [Auranofin co-treated with SN50 peptide] results in decreased expression of MCL1 protein
Auranofin results in decreased expression of MCL1 protein
CTD PMID:20542334 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein] CTD PMID:10820281 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein] CTD PMID:10820281 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 decreases activity
increases cleavage
ISO Auranofin results in decreased activity of PARP1 protein
Auranofin results in increased cleavage of PARP1 protein
CTD PMID:15159275 PMID:21370912 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ppif peptidylprolyl isomerase F increases oxidation
multiple interactions
ISO
EXP
Auranofin results in increased oxidation of PPIF protein
Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]; Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PPIF protein]
CTD PMID:26975474 NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913
JBrowse link
G Prdx3 peroxiredoxin 3 increases oxidation
multiple interactions
ISO
EXP
Auranofin results in increased oxidation of PRDX3 protein
Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PRDX3 protein]
Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of PRDX3 protein]
CTD PMID:18789312 PMID:21355852 PMID:26975474 NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [lipopolysaccharide A co-treated with Auranofin] results in decreased expression of PTGS2 protein
Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]
CTD PMID:10594346 PMID:17034761 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Auranofin results in decreased phosphorylation of RB1 protein CTD PMID:20542334 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Auranofin inhibits the reaction [IL1B protein affects the localization of RELA protein] CTD PMID:10594346 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G RT1-Ba RT1 class II, locus Ba increases response to substance ISO HLA-DQA1 gene polymorphism results in increased susceptibility to Auranofin CTD PMID:11436868 NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744
JBrowse link
G RT1-Db1 RT1 class II, locus Db1 increases response to substance ISO HLA-DRB1 gene polymorphism results in increased susceptibility to Auranofin CTD PMID:11436868 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Auranofin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases expression
multiple interactions
ISO Auranofin results in decreased expression of STAT3 protein modified form
[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of STAT3 protein
CTD PMID:20542334 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tbk1 TANK-binding kinase 1 multiple interactions ISO Auranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein] CTD PMID:17034761 NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892
JBrowse link
G Ticam1 toll-like receptor adaptor molecule 1 multiple interactions ISO Auranofin inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein] CTD PMID:17034761 NCBI chr 9:1,102,559...1,115,573
Ensembl chr 9:1,102,366...1,123,147
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Auranofin inhibits the reaction [lipopolysaccharide A promotes the reaction [TLR4 protein binds to TLR4 protein]] CTD PMID:17034761 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO Auranofin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Auranofin promotes the reaction [TNF protein results in increased activity of CASP3 protein]
Auranofin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:10820281 PMID:18789312 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Txn1 thioredoxin 1 increases oxidation ISO Auranofin results in increased oxidation of TXN protein CTD PMID:26975474 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Txn2 thioredoxin 2 increases oxidation
multiple interactions
ISO
EXP
Auranofin results in increased oxidation of TXN2 protein
Cyclosporine promotes the reaction [Auranofin results in increased oxidation of TXN2 protein]
CTD PMID:26975474 NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions
decreases activity
increases oxidation
increases expression
ISO
EXP
Auranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD1 protein]; Auranofin promotes the reaction [Sodium Selenite results in increased expression of TXNRD1 mRNA]; potassium tellurate(IV) promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]; Sodium Selenite promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]
Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]; Auranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]
Auranofin results in decreased activity of TXNRD1 protein
Auranofin results in increased expression of TXNRD1 mRNA
CTD PMID:16510263 PMID:18405881 PMID:18789312 PMID:19486940 PMID:20457604 More... NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Txnrd2 thioredoxin reductase 2 multiple interactions
decreases activity
ISO
EXP
Auranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD2 protein]; Auranofin promotes the reaction [Sodium Selenite results in decreased expression of TXNRD2 mRNA]
Auranofin results in decreased activity of TXNRD2 protein
CTD PMID:15458826 PMID:19486940 PMID:21172426 PMID:21355852 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
JBrowse link
sodium aurothiomalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ackr3 atypical chemokine receptor 3 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of ACKR3 mRNA CTD PMID:19192274 NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
JBrowse link
G Adora2a adenosine A2a receptor decreases expression ISO Gold Sodium Thiomalate results in decreased expression of ADORA2A mRNA CTD PMID:19192274 NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386
JBrowse link
G Amigo2 adhesion molecule with Ig like domain 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of AMIGO2 mRNA CTD PMID:19192274 NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695
JBrowse link
G Antxr1 ANTXR cell adhesion molecule 1 increases expression ISO Gold Sodium Thiomalate results in increased expression of ANTXR1 mRNA CTD PMID:19192274 NCBI chr 4:119,590,770...119,778,232
Ensembl chr 4:119,590,771...119,778,232
JBrowse link
G Aox1 aldehyde oxidase 1 increases expression ISO Gold Sodium Thiomalate results in increased expression of AOX1 mRNA CTD PMID:19192274 NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770
JBrowse link
G Bcl2a1 BCL2-related protein A1 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of BCL2A1 mRNA CTD PMID:19192274 NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998
JBrowse link
G Bst2 bone marrow stromal cell antigen 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of BST2 mRNA CTD PMID:19192274 NCBI chr16:18,217,404...18,220,979
Ensembl chr16:18,217,407...18,220,979
JBrowse link
G Ccl20 C-C motif chemokine ligand 20 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of CCL20 mRNA; Gold Sodium Thiomalate results in decreased expression of CCL20 protein CTD PMID:19192274 NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO Gold Sodium Thiomalate results in increased expression of CCN1 mRNA CTD PMID:19192274 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Ccn5 cellular communication network factor 5 increases expression ISO Gold Sodium Thiomalate results in increased expression of CCN5 mRNA CTD PMID:19192274 NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636
JBrowse link
G Cd28 Cd28 molecule multiple interactions
affects response to substance
ISO CD28 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
CD28 protein affects the susceptibility to Gold Sodium Thiomalate
CTD PMID:19077085 NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein] CTD PMID:10820281 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Clgn calmegin decreases expression ISO Gold Sodium Thiomalate results in decreased expression of CLGN mRNA CTD PMID:19192274 NCBI chr19:24,695,140...24,728,542
Ensembl chr19:24,696,875...24,728,758
JBrowse link
G Col1a1 collagen type I alpha 1 chain increases expression ISO Gold Sodium Thiomalate results in increased expression of COL1A1 mRNA CTD PMID:19192274 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Colec12 collectin sub-family member 12 increases expression ISO Gold Sodium Thiomalate results in increased expression of COLEC12 mRNA CTD PMID:19192274 NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of CXCL2 mRNA CTD PMID:19192274 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of CXCL1 mRNA CTD PMID:19192274 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cxcr4 C-X-C motif chemokine receptor 4 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of CXCR4 mRNA CTD PMID:19192274 NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883
JBrowse link
G Ddx10 DEAD-box helicase 10 increases expression ISO Gold Sodium Thiomalate results in increased expression of DDX10 mRNA CTD PMID:19192274 NCBI chr 8:53,488,656...53,643,373
Ensembl chr 8:53,488,656...53,643,373
JBrowse link
G Ddx58 DEXD/H-box helicase 58 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of DDX58 mRNA CTD PMID:19192274 NCBI chr 5:55,321,229...55,369,947
Ensembl chr 5:55,321,235...55,370,819
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Gold Sodium Thiomalate results in decreased activity of DIO1 protein CTD PMID:34662569 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Efemp1 EGF containing fibulin extracellular matrix protein 1 increases expression ISO Gold Sodium Thiomalate results in increased expression of EFEMP1 mRNA CTD PMID:19192274 NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018
JBrowse link
G Enpp2 ectonucleotide pyrophosphatase/phosphodiesterase 2 increases expression ISO Gold Sodium Thiomalate results in increased expression of ENPP2 mRNA CTD PMID:19192274 NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827
JBrowse link
G Entpd3 ectonucleoside triphosphate diphosphohydrolase 3 increases expression ISO Gold Sodium Thiomalate results in increased expression of ENTPD3 mRNA CTD PMID:19192274 NCBI chr 8:120,246,412...120,277,943
Ensembl chr 8:120,247,121...120,277,943
JBrowse link
G Fbl fibrillarin affects localization
decreases activity
multiple interactions
ISO Gold Sodium Thiomalate affects the localization of FBL protein
Gold Sodium Thiomalate results in decreased activity of FBL protein
CD28 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IFNG protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IL4 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IL6 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
CTD PMID:10942594 PMID:19077085 NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:83,469,832...83,478,932
JBrowse link
G Fbln1 fibulin 1 increases expression ISO Gold Sodium Thiomalate results in increased expression of FBLN1 mRNA CTD PMID:19192274 NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075
JBrowse link
G Fgf7 fibroblast growth factor 7 increases expression ISO Gold Sodium Thiomalate results in increased expression of FGF7 mRNA CTD PMID:19192274 NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929
JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of GBP1 mRNA CTD PMID:19192274 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
JBrowse link
G Gpm6b glycoprotein m6b increases expression ISO Gold Sodium Thiomalate results in increased expression of GPM6B mRNA CTD PMID:19192274 NCBI chr  X:28,057,788...28,204,409
Ensembl chr  X:28,059,450...28,204,211
JBrowse link
G Gsdme gasdermin E decreases expression ISO Gold Sodium Thiomalate results in decreased expression of GSDME mRNA CTD PMID:19192274 NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806
JBrowse link
G Herc6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of HERC6 mRNA CTD PMID:19192274 NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744
JBrowse link
G Hilpda hypoxia inducible lipid droplet-associated decreases expression ISO Gold Sodium Thiomalate results in decreased expression of HILPDA mRNA CTD PMID:19192274 NCBI chr 4:57,871,076...57,875,206
Ensembl chr 4:57,871,110...57,874,557
JBrowse link
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of HSD11B1 mRNA CTD PMID:19192274 NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687
JBrowse link
G Ifi27 interferon, alpha-inducible protein 27 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IFI27 mRNA CTD PMID:19192274 NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294
JBrowse link
G Ifi35 interferon-induced protein 35 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IFI35 mRNA CTD PMID:19192274 NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952
JBrowse link
G Ifi44 interferon-induced protein 44 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IFI44 mRNA CTD PMID:19192274 NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844
JBrowse link
G Ifi44l interferon-induced protein 44-like decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IFI44L mRNA CTD PMID:19192274 NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359
JBrowse link
G Ifih1 interferon induced with helicase C domain 1 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IFIH1 mRNA CTD PMID:19192274 NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IFIT3 mRNA CTD PMID:19192274 NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
JBrowse link
G Ifng interferon gamma multiple interactions
affects response to substance
ISO IFNG protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
IFNG protein affects the susceptibility to Gold Sodium Thiomalate
CTD PMID:19077085 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein] CTD PMID:10820281 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il10 interleukin 10 multiple interactions ISO [Gold Sodium Thiomalate co-treated with mercury nitrate analog] results in increased expression of IL10 protein CTD PMID:11824965 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Gold Sodium Thiomalate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Gold Sodium Thiomalate inhibits the reaction [IL1B protein results in increased expression of PTGES] CTD PMID:16393772 PMID:25314295 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IL1RN mRNA CTD PMID:19192274 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il23a interleukin 23 subunit alpha decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IL23A mRNA CTD PMID:19192274 NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
JBrowse link
G Il4 interleukin 4 multiple interactions
affects response to substance
ISO IL4 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
IL4 protein affects the susceptibility to Gold Sodium Thiomalate
CTD PMID:19077085 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions
decreases expression
affects response to substance
ISO [Gold Sodium Thiomalate co-treated with mercury nitrate analog] results in increased expression of IL6 protein
Gold Sodium Thiomalate results in decreased expression of IL6 mRNA; Gold Sodium Thiomalate results in decreased expression of IL6 protein
IL6 protein affects the susceptibility to Gold Sodium Thiomalate
IL6 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
CTD PMID:11824965 PMID:19077085 PMID:19192274 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of IRF7 mRNA CTD PMID:19192274 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Gold Sodium Thiomalate results in decreased expression of ISG15 mRNA CTD PMID:19192274 NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435
JBrowse link
G Isg20 interferon stimulated exonuclease gene 20 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of ISG20 mRNA CTD PMID:19192274 NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027
JBrowse link
G Lamb3 laminin subunit beta 3 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of LAMB3 mRNA CTD PMID:19192274 NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405
JBrowse link
G Lxn latexin increases expression ISO Gold Sodium Thiomalate results in increased expression of LXN mRNA CTD PMID:19192274 NCBI chr 2:151,727,556...151,733,426
Ensembl chr 2:151,727,102...151,733,460
JBrowse link
G Ly6e lymphocyte antigen 6 family member E decreases expression ISO Gold Sodium Thiomalate results in decreased expression of LY6E mRNA CTD PMID:19192274 NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689
JBrowse link
G Marcks myristoylated alanine rich protein kinase C substrate decreases expression ISO Gold Sodium Thiomalate results in decreased expression of MARCKS mRNA CTD PMID:19192274 NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases expression ISO Gold Sodium Thiomalate results in decreased expression of MET mRNA CTD PMID:19192274 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mir99b microRNA 99b multiple interactions ISO Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased expression of MIR99B mRNA] CTD PMID:33109608 NCBI chr 1:58,677,015...58,677,084
Ensembl chr 1:58,677,011...58,677,090
JBrowse link
G Mmp10 matrix metallopeptidase 10 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of MMP10 mRNA CTD PMID:19192274 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Mx1 MX dynamin like GTPase 1 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of MX1 mRNA CTD PMID:19192274 NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507
JBrowse link
G Ndufa4l2 NDUFA4, mitochondrial complex associated like 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of NDUFA4L2 mRNA CTD PMID:19192274 NCBI chr 7:63,351,021...63,359,010
Ensembl chr 7:63,356,883...63,359,010
JBrowse link
G Nmb neuromedin B decreases expression ISO Gold Sodium Thiomalate results in decreased expression of NMB mRNA CTD PMID:19192274 NCBI chr 1:134,869,446...134,875,507
Ensembl chr 1:134,869,446...134,872,190
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Gold Sodium Thiomalate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide] CTD PMID:16393772 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of NR4A3 mRNA CTD PMID:19192274 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO Gold Sodium Thiomalate results in decreased expression of OAS1 mRNA CTD PMID:19192274 NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517
JBrowse link
G Oasl 2'-5'-oligoadenylate synthetase-like decreases expression ISO Gold Sodium Thiomalate results in decreased expression of OASL mRNA CTD PMID:19192274 NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641
JBrowse link
G Olfml2b olfactomedin-like 2B increases expression ISO Gold Sodium Thiomalate results in increased expression of OLFML2B mRNA CTD PMID:19192274 NCBI chr13:82,869,414...82,906,607
Ensembl chr13:82,869,433...82,906,607
JBrowse link
G Phgdh phosphoglycerate dehydrogenase decreases expression ISO Gold Sodium Thiomalate results in decreased expression of PHGDH mRNA CTD PMID:19192274 NCBI chr 2:185,906,964...185,936,160
Ensembl chr 2:185,906,966...185,935,944
JBrowse link
G Plpp3 phospholipid phosphatase 3 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of PLPP3 mRNA CTD PMID:19192274 NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205
JBrowse link
G Ppp4r2 protein phosphatase 4, regulatory subunit 2 increases expression ISO Gold Sodium Thiomalate results in increased expression of PPP4R2 mRNA CTD PMID:19192274 NCBI chr 4:133,454,555...133,495,486
Ensembl chr 4:133,454,555...133,495,486
JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO Gold Sodium Thiomalate inhibits the reaction [IL1B protein results in increased expression of PTGES] CTD PMID:25314295 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of PTGS2 mRNA CTD PMID:19192274 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rarres1 retinoic acid receptor responder 1 increases expression ISO Gold Sodium Thiomalate results in increased expression of RARRES1 mRNA CTD PMID:19192274 NCBI chr 2:151,749,715...151,783,975
Ensembl chr 2:151,749,715...151,783,978
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:33109608 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rgs4 regulator of G-protein signaling 4 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of RGS4 mRNA CTD PMID:19192274 NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of RIPK2 mRNA CTD PMID:19192274 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link
G Rnf19b ring finger protein 19B decreases expression ISO Gold Sodium Thiomalate results in decreased expression of RNF19B mRNA CTD PMID:19192274 NCBI chr 5:141,406,085...141,431,380
Ensembl chr 5:141,406,118...141,431,380
JBrowse link
G Rsad2 radical S-adenosyl methionine domain containing 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of RSAD2 mRNA CTD PMID:19192274 NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
JBrowse link
G Slc7a11 solute carrier family 7 member 11 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of SLC7A11 mRNA CTD PMID:19192274 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
JBrowse link
G Sms spermine synthase decreases expression ISO Gold Sodium Thiomalate results in decreased expression of SMS mRNA CTD PMID:19192274 NCBI chr  X:37,516,949...37,572,657
Ensembl chr  X:37,516,931...37,570,822
JBrowse link
G Sod2 superoxide dismutase 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of SOD2 mRNA CTD PMID:19192274 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Spon1 spondin 1 increases expression ISO Gold Sodium Thiomalate results in increased expression of SPON1 mRNA CTD PMID:19192274 NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226
JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of STAT1 mRNA CTD PMID:19192274 NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
JBrowse link
G Sts steroid sulfatase increases expression ISO Gold Sodium Thiomalate results in increased expression of STS mRNA CTD PMID:19192274 NCBI chr  X:42,225,131...42,233,403
Ensembl chr  X:42,225,372...42,233,402
JBrowse link
G Thbs1 thrombospondin 1 increases expression ISO Gold Sodium Thiomalate results in increased expression of THBS1 mRNA CTD PMID:19192274 NCBI chr 3:105,056,286...105,071,445
Ensembl chr 3:105,056,292...105,071,440
JBrowse link
G Thbs2 thrombospondin 2 increases expression ISO Gold Sodium Thiomalate results in increased expression of THBS2 mRNA CTD PMID:19192274 NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789
JBrowse link
G Tlr2 toll-like receptor 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of TLR2 mRNA CTD PMID:19192274 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tnfaip2 TNF alpha induced protein 2 decreases expression ISO Gold Sodium Thiomalate results in decreased expression of TNFAIP2 mRNA CTD PMID:19192274 NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Gold Sodium Thiomalate results in increased expression of TXNIP mRNA CTD PMID:19192274 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Txnrd1 thioredoxin reductase 1 multiple interactions
decreases activity
ISO
EXP
Gold Sodium Thiomalate inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]
Gold Sodium Thiomalate results in decreased activity of TXNRD1 protein
CTD PMID:16510263 PMID:17229725 NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
JBrowse link
G Txnrd2 thioredoxin reductase 2 decreases activity EXP Gold Sodium Thiomalate results in decreased activity of TXNRD2 protein CTD PMID:15458826 NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
JBrowse link
sodium aurothiosulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO Gold Sodium Thiosulfate binds to ALB protein CTD PMID:16791640 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Cd40 CD40 molecule increases expression ISO Gold Sodium Thiosulfate results in increased expression of CD40 protein CTD PMID:25458486 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534
JBrowse link
G Il6 interleukin 6 increases secretion ISO Gold Sodium Thiosulfate results in increased secretion of IL6 protein CTD PMID:25458486 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO TLR3 protein affects the reaction [Gold Sodium Thiosulfate results in increased secretion of CXCL8 protein] CTD PMID:25458486 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20089
    chemical entity 20088
      molecular entity 20058
        transition element molecular entity 16690
          transition element coordination entity 11257
            gold coordination entity 125
              auranofin 41
              aurothiomalic acid + 0
              aurothiosulfate(3-) + 4
              dicyanoaurate(1-) + 0
              digold hexachloride 0
              gold pentafluoride 0
              gold tribromide 0
              gold trichloride 0
              gold trifluoride 0
              hexafluoroaurate(1-) 0
              monosodium aurothiomalate + 90
              tetraamminegold(3+) 0
              tetrabromoaurate(1-) + 0
              tetrachloroaurate(1-) + 0
              tetracyanoaurate(1-) 0
              tetrafluoroaurate(1-) 0
              tetranitratoaurate(1-) 0
              tetraxenonogold(2+) + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20089
    subatomic particle 20058
      composite particle 20058
        hadron 20088
          baryon 20088
            nucleon 20088
              atomic nucleus 20088
                atom 20058
                  metal atom 17612
                    transition element atom 16984
                      d-block element atom 16957
                        copper group element atom 9537
                          gold atom 549
                            gold molecular entity 549
                              gold coordination entity 125
                                auranofin 41
                                aurothiomalic acid + 0
                                aurothiosulfate(3-) + 4
                                dicyanoaurate(1-) + 0
                                digold hexachloride 0
                                gold pentafluoride 0
                                gold tribromide 0
                                gold trichloride 0
                                gold trifluoride 0
                                hexafluoroaurate(1-) 0
                                monosodium aurothiomalate + 90
                                tetraamminegold(3+) 0
                                tetrabromoaurate(1-) + 0
                                tetrachloroaurate(1-) + 0
                                tetracyanoaurate(1-) 0
                                tetrafluoroaurate(1-) 0
                                tetranitratoaurate(1-) 0
                                tetraxenonogold(2+) + 0
paths to the root