gold coordination entity - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	gold coordination entity	go back to main search page
Accession:	CHEBI:33971	browse the term
Synonyms:	related_synonym:	gold coordination compounds; gold coordination entities

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Rat (134) Mouse (135) Human (139) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (0) Green Monkey (0) Naked Mole-rat (0) All
Genes (134)

auranofin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

Auranofin promotes the reaction [arsenite results in increased phosphorylation of AKT1 protein]

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

albumin

affects binding

Auranofin analog binds to ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

BCL2-antagonist/killer 1

multiple interactions
increases response to substance

[BAX co-treated with BAK1] results in increased susceptibility to Auranofin; BAK1 mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAK1 results in increased susceptibility to Auranofin

PMID:18789312 PMID:21172426

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases response to substance

[BAX co-treated with BAK1] results in increased susceptibility to Auranofin; BAX mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAX results in increased susceptibility to Auranofin

PMID:18789312 PMID:21172426

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

multiple interactions

BCL2 protein inhibits the reaction [Auranofin results in increased activity of CASP3 protein]

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

caspase 3

multiple interactions
increases activity

Auranofin promotes the reaction [TNF protein results in increased activity of CASP3 protein]; Auranofin results in decreased expression of and results in increased cleavage of CASP3 protein; BCL2 protein inhibits the reaction [Auranofin results in increased activity of CASP3 protein]
BAK1 mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]; BAX mutant form inhibits the reaction [Auranofin results in increased activity of CASP3 protein]

PMID:15159275 PMID:15191400 PMID:18789312 PMID:20542334 PMID:21699084

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

multiple interactions

Auranofin results in decreased expression of and results in increased cleavage of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions

Auranofin results in decreased expression of and results in increased cleavage of CASP9 protein

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

cyclin-dependent kinase inhibitor 1A

increases expression

Auranofin results in increased expression of CDKN1A protein

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

CCAAT/enhancer binding protein epsilon

multiple interactions

[Auranofin co-treated with Tretinoin] results in increased expression of CEBPE protein

NCBI chr15:28,169,711...28,171,471
Ensembl chr15:28,169,704...28,171,814

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

Auranofin inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased activity of CHUK protein]; Auranofin inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]
Auranofin inhibits the reaction [TNF protein results in increased activity of CHUK protein]

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

iodothyronine deiodinase 1

decreases activity

Auranofin results in decreased activity of DIO1 protein

NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970

G

epidermal growth factor

multiple interactions

Auranofin promotes the reaction [arsenite results in increased expression of and results in increased secretion of EGF protein]

NCBI chr 2:218,219,408...218,302,359
Ensembl chr 2:218,219,415...218,302,064

G

glutathione peroxidase 1

multiple interactions
increases expression

[Peptidoglycan co-treated with Lipopolysaccharides] promotes the reaction [Auranofin results in increased expression of GPX1 protein]; Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of GPX1 protein]

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione-disulfide reductase

multiple interactions

Auranofin promotes the reaction [arsenite results in increased activity of GSR protein]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

heme oxygenase 1

increases expression

Auranofin results in increased expression of HMOX1 mRNA
Auranofin results in increased expression of HMOX1 mRNA; Auranofin results in increased expression of HMOX1 protein

PMID:22008538 PMID:23942037

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

interleukin 1 beta

multiple interactions

Auranofin inhibits the reaction [IL1B protein affects the localization of RELA protein]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of IL6ST protein; [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of JAK2 protein; [Auranofin co-treated with IL6 protein] results in decreased phosphorylation of STAT3 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 cytokine family signal transducer

multiple interactions

[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of IL6ST protein

NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936

G

interleukin-1 receptor-associated kinase 1

multiple interactions

Auranofin inhibits the reaction [lipopolysaccharide A results in increased degradation of IRAK1 protein]

NCBI chr X:151,768,621...151,778,521
Ensembl chr X:151,768,777...151,778,521

G

interferon regulatory factor 3

multiple interactions

Auranofin inhibits the reaction [lipopolysaccharide A results in increased activity of IRF3 protein]; Auranofin inhibits the reaction [lipopolysaccharide A results in increased phosphorylation of IRF3 protein]; Auranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]; Auranofin inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein]

NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935

G

integrin subunit alpha M

multiple interactions

[Auranofin co-treated with Tretinoin] results in increased expression of ITGAM protein

NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503

G

Janus kinase 2

multiple interactions

[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of JAK2 protein

NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189

G

mitogen activated protein kinase 1

multiple interactions

Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK1 protein]

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

mitogen-activated protein kinase 8

multiple interactions

Auranofin promotes the reaction [arsenite results in increased phosphorylation of MAPK8 protein]

NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981

G

MCL1 apoptosis regulator, BCL2 family member

multiple interactions
decreases expression

[Auranofin co-treated with SN50 peptide] results in decreased expression of MCL1 protein
Auranofin results in decreased expression of MCL1 protein

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

G

NFE2 like bZIP transcription factor 2

multiple interactions

Auranofin promotes the reaction [arsenite results in increased expression of NFE2L2 protein]

NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737

G

NFKB inhibitor alpha

multiple interactions

Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

NFKB inhibitor beta

multiple interactions

Auranofin inhibits the reaction [Lipopolysaccharides results in increased degradation of NFKBIB protein]

NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862

G

poly (ADP-ribose) polymerase 1

decreases activity
increases cleavage

Auranofin results in decreased activity of PARP1 protein
Auranofin results in increased cleavage of PARP1 protein

PMID:15159275 PMID:21370912

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

peptidylprolyl isomerase F

increases oxidation
multiple interactions

Auranofin results in increased oxidation of PPIF protein
Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]; Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PPIF protein]

NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913

G

peroxiredoxin 3

increases oxidation
multiple interactions

Auranofin results in increased oxidation of PRDX3 protein
Cyclosporine promotes the reaction [Auranofin results in increased oxidation of PRDX3 protein]
Auranofin promotes the reaction [[Lipopolysaccharides co-treated with Peptidoglycan] results in increased expression of PRDX3 protein]

PMID:18789312 PMID:21355852 PMID:26975474

NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[lipopolysaccharide A co-treated with Auranofin] results in decreased expression of PTGS2 protein
Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; Auranofin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]

PMID:10594346 PMID:17034761

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

RB transcriptional corepressor 1

decreases phosphorylation

Auranofin results in decreased phosphorylation of RB1 protein

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RNA binding motif, single stranded interacting protein 3

affects response to substance

RBMS3 protein affects the susceptibility to Auranofin

NCBI chr 8:116,305,227...117,625,730
Ensembl chr 8:116,309,882...117,625,423

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Auranofin inhibits the reaction [IL1B protein affects the localization of RELA protein]; Auranofin promotes the reaction [arsenite results in increased phosphorylation of RELA protein]

PMID:10594346 PMID:36343453

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

RT1 class II, locus Ba

increases response to substance

HLA-DQA1 gene polymorphism results in increased susceptibility to Auranofin

NCBI chr20:4,575,134...4,579,727
Ensembl chr20:4,575,134...4,579,744

G

RT1 class II, locus Db1

increases response to substance

HLA-DRB1 gene polymorphism results in increased susceptibility to Auranofin

NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258

G

solute carrier family 22 member 2

multiple interactions

Auranofin inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

signal transducer and activator of transcription 3

decreases expression
multiple interactions

Auranofin results in decreased expression of STAT3 protein modified form
[Auranofin co-treated with IL6 protein] results in decreased phosphorylation of STAT3 protein

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

G

TANK-binding kinase 1

multiple interactions

Auranofin inhibits the reaction [TBK1 protein results in increased activity of IRF3 protein]

NCBI chr 7:57,077,830...57,110,868
Ensembl chr 7:57,077,830...57,110,892

G

transforming growth factor alpha

multiple interactions

Auranofin promotes the reaction [arsenite results in increased expression of and results in increased secretion of TGFA protein]

NCBI chr 4:118,618,043...118,700,897
Ensembl chr 4:118,618,269...118,700,894

G

TIR domain containing adaptor molecule 1

multiple interactions

Auranofin inhibits the reaction [TICAM1 protein results in increased activity of IRF3 protein]

NCBI chr 9:1,102,559...1,111,023
Ensembl chr 9:1,102,366...1,123,147

G

toll-like receptor 4

multiple interactions

Auranofin inhibits the reaction [lipopolysaccharide A promotes the reaction [TLR4 protein binds to TLR4 protein]]

NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions

Auranofin inhibits the reaction [TNF protein results in increased activity of CHUK protein]; Auranofin promotes the reaction [TNF protein results in increased activity of CASP3 protein]
Auranofin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]

PMID:10820281 PMID:18789312

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

thioredoxin 1

increases oxidation
multiple interactions

Auranofin results in increased oxidation of TXN protein
Auranofin inhibits the reaction [arsenite results in increased expression of TXN protein]

PMID:26975474 PMID:36343453

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin 2

increases oxidation
multiple interactions

Auranofin results in increased oxidation of TXN2 protein
Cyclosporine promotes the reaction [Auranofin results in increased oxidation of TXN2 protein]

NCBI chr 7:109,496,772...109,510,378
Ensembl chr 7:109,496,761...109,510,359

G

thioredoxin reductase 1

multiple interactions
decreases activity
increases oxidation
increases expression

Auranofin inhibits the reaction [arsenite results in increased expression of and results in increased activity of TXNRD1 protein]; Auranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD1 protein]; Auranofin promotes the reaction [Sodium Selenite results in increased expression of TXNRD1 mRNA]; potassium tellurate(IV) promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]; Sodium Selenite promotes the reaction [Auranofin results in increased oxidation of TXNRD1 protein]
Auranofin inhibits the reaction [[NADP co-treated with TXNRD1 protein] results in increased activity of PPIF protein]; Auranofin inhibits the reaction [[TXNRD1 protein co-treated with NADP] results in increased abundance of Superoxides]
Auranofin results in decreased activity of TXNRD1 protein
Auranofin results in increased expression of TXNRD1 mRNA

PMID:16510263 PMID:18405881 PMID:18789312 PMID:19486940 PMID:20457604 More...

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

thioredoxin reductase 2

multiple interactions
decreases activity

Auranofin inhibits the reaction [Sodium Selenite results in increased activity of TXNRD2 protein]; Auranofin promotes the reaction [Sodium Selenite results in decreased expression of TXNRD2 mRNA]
Auranofin results in decreased activity of TXNRD2 protein

PMID:15458826 PMID:19486940 PMID:21172426 PMID:21355852

NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156

sodium aurothiomalate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

atypical chemokine receptor 3

decreases expression

Gold Sodium Thiomalate results in decreased expression of ACKR3 mRNA

NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237

G

adenosine A2a receptor

decreases expression

Gold Sodium Thiomalate results in decreased expression of ADORA2A mRNA

NCBI chr20:13,315,848...13,333,386
Ensembl chr20:13,315,853...13,333,386

G

adhesion molecule with Ig like domain 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of AMIGO2 mRNA

NCBI chr 7:128,391,493...128,394,589
Ensembl chr 7:128,390,412...128,394,695

G

ANTXR cell adhesion molecule 1

increases expression

Gold Sodium Thiomalate results in increased expression of ANTXR1 mRNA

NCBI chr 4:119,590,770...119,778,232
Ensembl chr 4:119,590,771...119,778,232

G

aldehyde oxidase 1

increases expression

Gold Sodium Thiomalate results in increased expression of AOX1 mRNA

NCBI chr 9:59,579,621...59,658,772
Ensembl chr 9:59,579,649...59,658,770

G

BCL2-related protein A1

decreases expression

Gold Sodium Thiomalate results in decreased expression of BCL2A1 mRNA

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

G

bone marrow stromal cell antigen 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of BST2 mRNA

NCBI chr16:18,216,605...18,220,979
Ensembl chr16:18,217,407...18,220,979

G

C-C motif chemokine ligand 20

decreases expression

Gold Sodium Thiomalate results in decreased expression of CCL20 mRNA; Gold Sodium Thiomalate results in decreased expression of CCL20 protein

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

cellular communication network factor 1

increases expression

Gold Sodium Thiomalate results in increased expression of CCN1 mRNA

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cellular communication network factor 5

increases expression

Gold Sodium Thiomalate results in increased expression of CCN5 mRNA

NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636

G

Cd28 molecule

multiple interactions
affects response to substance

CD28 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
CD28 protein affects the susceptibility to Gold Sodium Thiomalate

NCBI chr 9:62,166,324...62,194,674
Ensembl chr 9:62,166,192...62,194,685

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased activity of CHUK protein]

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

calmegin

decreases expression

Gold Sodium Thiomalate results in decreased expression of CLGN mRNA

NCBI chr19:24,695,140...24,728,542
Ensembl chr19:24,696,875...24,728,758

G

collagen type I alpha 1 chain

increases expression

Gold Sodium Thiomalate results in increased expression of COL1A1 mRNA

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collectin sub-family member 12

increases expression

Gold Sodium Thiomalate results in increased expression of COLEC12 mRNA

NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618

G

C-X-C motif chemokine ligand 1

decreases expression

Gold Sodium Thiomalate results in decreased expression of CXCL1 mRNA

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

decreases expression

Gold Sodium Thiomalate results in decreased expression of CXCL1 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine receptor 4

decreases expression

Gold Sodium Thiomalate results in decreased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

DEAD-box helicase 10

increases expression

Gold Sodium Thiomalate results in increased expression of DDX10 mRNA

NCBI chr 8:53,488,656...53,643,373
Ensembl chr 8:53,488,656...53,643,373

G

iodothyronine deiodinase 1

decreases activity

Gold Sodium Thiomalate results in decreased activity of DIO1 protein

NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970

G

EGF containing fibulin extracellular matrix protein 1

increases expression

Gold Sodium Thiomalate results in increased expression of EFEMP1 mRNA

NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

increases expression

Gold Sodium Thiomalate results in increased expression of ENPP2 mRNA

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

ectonucleoside triphosphate diphosphohydrolase 3

increases expression

Gold Sodium Thiomalate results in increased expression of ENTPD3 mRNA

NCBI chr 8:120,246,412...120,277,943
Ensembl chr 8:120,247,121...120,277,943

G

fibrillarin

affects localization
multiple interactions
decreases activity

Gold Sodium Thiomalate affects the localization of FBL protein
CD28 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IFNG protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IL4 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]; IL6 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]

PMID:10942594 PMID:19077085

NCBI chr 1:83,469,832...83,478,932
Ensembl chr 1:83,469,832...83,478,932

G

fibulin 1

increases expression

Gold Sodium Thiomalate results in increased expression of FBLN1 mRNA

NCBI chr 7:116,310,582...116,390,075
Ensembl chr 7:116,310,582...116,390,075

G

fibroblast growth factor 7

increases expression

Gold Sodium Thiomalate results in increased expression of FGF7 mRNA

NCBI chr 3:113,280,448...113,333,279
Ensembl chr 3:113,281,283...113,332,929

G

guanylate binding protein 1

decreases expression

Gold Sodium Thiomalate results in decreased expression of GBP1 mRNA

NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131
Ensembl chr 2:231,398,163...231,432,131

G

glycoprotein m6b

increases expression

Gold Sodium Thiomalate results in increased expression of GPM6B mRNA

NCBI chr X:28,057,788...28,204,409
Ensembl chr X:28,059,450...28,204,211

G

gasdermin E

decreases expression

Gold Sodium Thiomalate results in decreased expression of GSDME mRNA

NCBI chr 4:79,258,799...79,321,129
Ensembl chr 4:79,257,804...79,320,806

G

HECT and RLD domain containing E3 ubiquitin protein ligase family member 6

decreases expression

Gold Sodium Thiomalate results in decreased expression of HERC6 mRNA

NCBI chr 4:87,524,470...87,566,895
Ensembl chr 4:87,524,493...87,581,744

G

hypoxia inducible lipid droplet-associated

decreases expression

Gold Sodium Thiomalate results in decreased expression of HILPDA mRNA

NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557

G

hydroxysteroid 11-beta dehydrogenase 1

decreases expression

Gold Sodium Thiomalate results in decreased expression of HSD11B1 mRNA

NCBI chr13:104,728,539...104,798,884
Ensembl chr13:104,728,539...104,788,687

G

interferon, alpha-inducible protein 27

decreases expression

Gold Sodium Thiomalate results in decreased expression of IFI27 mRNA

NCBI chr 6:122,590,461...122,596,996
Ensembl chr 6:122,590,472...122,779,294

G

interferon-induced protein 35

decreases expression

Gold Sodium Thiomalate results in decreased expression of IFI35 mRNA

NCBI chr10:86,381,023...86,389,279
Ensembl chr10:86,381,010...86,389,952

G

interferon-induced protein 44

decreases expression

Gold Sodium Thiomalate results in decreased expression of IFI44 mRNA

NCBI chr 2:240,626,058...240,643,879
Ensembl chr 2:240,626,066...240,643,844

G

interferon-induced protein 44-like

decreases expression

Gold Sodium Thiomalate results in decreased expression of IFI44L mRNA

NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359

G

interferon induced with helicase C domain 1

decreases expression

Gold Sodium Thiomalate results in decreased expression of IFIH1 mRNA

NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456

G

interferon-induced protein with tetratricopeptide repeats 3

decreases expression

Gold Sodium Thiomalate results in decreased expression of IFIT3 mRNA

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307

G

interferon gamma

multiple interactions
affects response to substance

IFNG protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
IFNG protein affects the susceptibility to Gold Sodium Thiomalate

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

inhibitor of nuclear factor kappa B kinase subunit beta

multiple interactions

Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein]

NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250

G

interleukin 10

multiple interactions

[Gold Sodium Thiomalate co-treated with mercury nitrate analog] results in increased expression of IL10 protein

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions

Gold Sodium Thiomalate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; Gold Sodium Thiomalate inhibits the reaction [IL1B protein results in increased expression of PTGES]

PMID:16393772 PMID:25314295

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

decreases expression

Gold Sodium Thiomalate results in decreased expression of IL1RN mRNA

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 23 subunit alpha

decreases expression

Gold Sodium Thiomalate results in decreased expression of IL23A mRNA

NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923

G

interleukin 4

multiple interactions
affects response to substance

IL4 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
IL4 protein affects the susceptibility to Gold Sodium Thiomalate

NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
affects response to substance
decreases expression

[Gold Sodium Thiomalate co-treated with mercury nitrate analog] results in increased expression of IL6 protein
IL6 protein affects the reaction [Gold Sodium Thiomalate results in decreased activity of FBL protein]
IL6 protein affects the susceptibility to Gold Sodium Thiomalate
Gold Sodium Thiomalate results in decreased expression of IL6 mRNA; Gold Sodium Thiomalate results in decreased expression of IL6 protein

PMID:11824965 PMID:19077085 PMID:19192274

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

interferon regulatory factor 7

decreases expression

Gold Sodium Thiomalate results in decreased expression of IRF7 mRNA

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

ISG15 ubiquitin-like modifier

decreases expression

Gold Sodium Thiomalate results in decreased expression of ISG15 mRNA

NCBI chr 5:166,784,148...166,785,435
Ensembl chr 5:166,784,148...166,785,435

G

interferon stimulated exonuclease gene 20

decreases expression

Gold Sodium Thiomalate results in decreased expression of ISG20 mRNA

NCBI chr 1:132,829,303...132,837,027
Ensembl chr 1:132,815,123...132,837,027

G

laminin subunit beta 3

decreases expression

Gold Sodium Thiomalate results in decreased expression of LAMB3 mRNA

NCBI chr13:104,833,810...104,875,405
Ensembl chr13:104,833,873...104,875,405

G

latexin

increases expression

Gold Sodium Thiomalate results in increased expression of LXN mRNA

NCBI chr 2:151,727,556...151,733,426
Ensembl chr 2:151,727,102...151,733,460

G

lymphocyte antigen 6 family member E

decreases expression

Gold Sodium Thiomalate results in decreased expression of LY6E mRNA

NCBI chr 7:106,935,530...106,939,689
Ensembl chr 7:106,935,761...106,939,689

G

myristoylated alanine rich protein kinase C substrate

decreases expression

Gold Sodium Thiomalate results in decreased expression of MARCKS mRNA

NCBI chr20:40,685,315...40,691,012
Ensembl chr20:40,685,315...40,691,012

G

MET proto-oncogene, receptor tyrosine kinase

decreases expression

Gold Sodium Thiomalate results in decreased expression of MET mRNA

NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876

G

microRNA 99b

multiple interactions

Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased expression of MIR99B mRNA]

NCBI chr 1:58,677,015...58,677,084
Ensembl chr 1:58,677,011...58,677,090

G

matrix metallopeptidase 10

decreases expression

Gold Sodium Thiomalate results in decreased expression of MMP10 mRNA

NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748

G

MX dynamin like GTPase 1

decreases expression

Gold Sodium Thiomalate results in decreased expression of MX1 mRNA

NCBI chr11:36,799,659...36,825,209
Ensembl chr11:36,799,660...36,823,507

G

NDUFA4, mitochondrial complex associated like 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of NDUFA4L2 mRNA

NCBI chr 7:63,351,021...63,359,010
Ensembl chr 7:63,356,883...63,359,010

G

neuromedin B

decreases expression

Gold Sodium Thiomalate results in decreased expression of NMB mRNA

NCBI chr 1:134,869,446...134,875,507
Ensembl chr 1:134,869,446...134,872,190

G

nitric oxide synthase 2

multiple interactions

Gold Sodium Thiomalate inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nuclear receptor subfamily 4, group A, member 3

decreases expression

Gold Sodium Thiomalate results in decreased expression of NR4A3 mRNA

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

2'-5' oligoadenylate synthetase 1A

decreases expression

Gold Sodium Thiomalate results in decreased expression of OAS1 mRNA

NCBI chr12:35,669,798...35,680,505
Ensembl chr12:35,669,801...35,680,517

G

2'-5'-oligoadenylate synthetase-like

decreases expression

Gold Sodium Thiomalate results in decreased expression of OASL mRNA

NCBI chr12:41,682,900...41,695,641
Ensembl chr12:41,682,900...41,695,641

G

olfactomedin-like 2B

increases expression

Gold Sodium Thiomalate results in increased expression of OLFML2B mRNA

NCBI chr13:82,869,414...82,906,607
Ensembl chr13:82,869,433...82,906,607

G

phosphoglycerate dehydrogenase

decreases expression

Gold Sodium Thiomalate results in decreased expression of PHGDH mRNA

NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944

G

phospholipid phosphatase 3

decreases expression

Gold Sodium Thiomalate results in decreased expression of PLPP3 mRNA

NCBI chr 5:119,927,085...120,002,206
Ensembl chr 5:119,927,085...120,002,205

G

protein phosphatase 4, regulatory subunit 2

increases expression

Gold Sodium Thiomalate results in increased expression of PPP4R2 mRNA

NCBI chr 4:133,454,555...133,495,486
Ensembl chr 4:133,454,555...133,495,486

G

prostaglandin E synthase

multiple interactions

Gold Sodium Thiomalate inhibits the reaction [IL1B protein results in increased expression of PTGES]

NCBI chr 3:14,177,892...14,189,236

G

prostaglandin-endoperoxide synthase 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

retinoic acid receptor responder 1

increases expression

Gold Sodium Thiomalate results in increased expression of RARRES1 mRNA

NCBI chr 2:151,749,715...151,783,975
Ensembl chr 2:151,749,715...151,783,978

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Gold Sodium Thiomalate inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

regulator of G-protein signaling 4

decreases expression

Gold Sodium Thiomalate results in decreased expression of RGS4 mRNA

NCBI chr13:81,936,775...81,943,103
Ensembl chr13:81,936,775...81,943,068

G

RNA sensor RIG-1

decreases expression

Gold Sodium Thiomalate results in decreased expression of RIGI mRNA

NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819

G

receptor-interacting serine-threonine kinase 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of RIPK2 mRNA

NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657

G

ring finger protein 19B

decreases expression

Gold Sodium Thiomalate results in decreased expression of RNF19B mRNA

NCBI chr 5:141,406,085...141,431,376
Ensembl chr 5:141,406,118...141,431,380

G

radical S-adenosyl methionine domain containing 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of RSAD2 mRNA

NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699

G

solute carrier family 7 member 11

decreases expression

Gold Sodium Thiomalate results in decreased expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

spermine synthase

decreases expression

Gold Sodium Thiomalate results in decreased expression of SMS mRNA

NCBI chr X:37,516,949...37,572,657
Ensembl chr X:37,516,931...37,570,822

G

superoxide dismutase 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of SOD2 mRNA

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

G

spondin 1

increases expression

Gold Sodium Thiomalate results in increased expression of SPON1 mRNA

NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226

G

signal transducer and activator of transcription 1

decreases expression

Gold Sodium Thiomalate results in decreased expression of STAT1 mRNA

NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540

G

steroid sulfatase

increases expression

Gold Sodium Thiomalate results in increased expression of STS mRNA

NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402

G

thrombospondin 1

increases expression

Gold Sodium Thiomalate results in increased expression of THBS1 mRNA

NCBI chr 3:105,056,293...105,071,445
Ensembl chr 3:105,056,292...105,071,440

G

thrombospondin 2

increases expression

Gold Sodium Thiomalate results in increased expression of THBS2 mRNA

NCBI chr 1:55,670,394...55,699,789
Ensembl chr 1:55,670,394...55,699,789

G

toll-like receptor 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of TLR2 mRNA

NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630

G

TNF alpha induced protein 2

decreases expression

Gold Sodium Thiomalate results in decreased expression of TNFAIP2 mRNA

NCBI chr 6:130,476,832...130,489,914
Ensembl chr 6:130,476,889...130,489,914

G

thioredoxin interacting protein

increases expression

Gold Sodium Thiomalate results in increased expression of TXNIP mRNA

NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886

G

thioredoxin reductase 1

multiple interactions
decreases activity

Gold Sodium Thiomalate inhibits the reaction [TXNRD1 protein affects the metabolism of Dithionitrobenzoic Acid]
Gold Sodium Thiomalate results in decreased activity of TXNRD1 protein

PMID:16510263 PMID:17229725

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

G

thioredoxin reductase 2

decreases activity

Gold Sodium Thiomalate results in decreased activity of TXNRD2 protein

NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156

sodium aurothiosulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

affects binding

Gold Sodium Thiosulfate binds to ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

CD40 molecule

increases expression

Gold Sodium Thiosulfate results in increased expression of CD40 protein

NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534

G

interleukin 6

increases secretion

Gold Sodium Thiosulfate results in increased secretion of IL6 protein

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

toll-like receptor 3

multiple interactions

TLR3 protein affects the reaction [Gold Sodium Thiosulfate results in increased secretion of CXCL8 protein]

NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19932
chemical entity	19930
molecular entity	19930
transition element molecular entity	17029
transition element coordination entity	11742
gold coordination entity	134
auranofin	50
aurothiomalic acid +	0
aurothiosulfate(3-) +	4
dicyanoaurate(1-) +	0
digold hexachloride	0
gold pentafluoride	0
gold tribromide	0
gold trichloride	0
gold trifluoride	0
hexafluoroaurate(1-)	0
monosodium aurothiomalate +	90
tetraamminegold(3+)	0
tetrabromoaurate(1-) +	0
tetrachloroaurate(1-) +	0
tetracyanoaurate(1-)	0
tetrafluoroaurate(1-)	0
tetranitratoaurate(1-)	0
tetraxenonogold(2+) +	0
Path 2
Term	Annotations
CHEBI ontology	19932
subatomic particle	19930
composite particle	19930
hadron	19930
baryon	19930
nucleon	19930
atomic nucleus	19930
atom	19930
metal atom	17876
transition element atom	17232
d-block element atom	17227
copper group element atom	9728
gold atom	614
gold molecular entity	614
gold coordination entity	134
auranofin	50
aurothiomalic acid +	0
aurothiosulfate(3-) +	4
dicyanoaurate(1-) +	0
digold hexachloride	0
gold pentafluoride	0
gold tribromide	0
gold trichloride	0
gold trifluoride	0
hexafluoroaurate(1-)	0
monosodium aurothiomalate +	90
tetraamminegold(3+)	0
tetrabromoaurate(1-) +	0
tetrachloroaurate(1-) +	0
tetracyanoaurate(1-)	0
tetrafluoroaurate(1-)	0
tetranitratoaurate(1-)	0
tetraxenonogold(2+) +	0

paths to the root