elemental gold - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	elemental gold	go back to main search page
Accession:	CHEBI:33970	browse the term

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Genes (512)

gold nanoparticle

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tumor necrosis factor

decreases secretion

EXP

Topical GNP decreases secretion of Tnf protein in aqeous humor

RGD

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aminoadipate-semialdehyde synthase

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of AASS mRNA
Gold analog results in decreased expression of AASS mRNA

PMID:28433809 PMID:36057382

NCBI chr 4:52,572,146...52,628,811
Ensembl chr 4:51,606,462...51,663,136

G

ATP binding cassette subfamily B member 1A

increases expression

ISO

Gold analog results in increased expression of ABCB1 mRNA

NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709

G

ATP binding cassette subfamily B member 4

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of ABCB4 mRNA
Gold analog results in decreased expression of ABCB4 mRNA

PMID:28433809 PMID:36057382

NCBI chr 4:26,106,895...26,164,440
Ensembl chr 4:25,151,953...25,209,202

G

ATP binding cassette subfamily C member 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of ABCC1 mRNA

NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

increases expression

ISO

Gold analog results in increased expression of ABCC2 mRNA

NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238

G

ABL proto-oncogene 1, non-receptor tyrosine kinase

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of ABL1 mRNA

NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065

G

acetyl-CoA acyltransferase 1A

decreases expression

ISO

Gold analog results in decreased expression of ACAA1 mRNA

NCBI chr 8:119,079,401...119,088,626
Ensembl chr 8:119,079,775...119,088,624

G

acetyl-CoA carboxylase alpha

decreases expression

ISO

Gold analog results in decreased expression of ACACA mRNA

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,014,170...69,276,457

G

acyl-CoA dehydrogenase family, member 11

decreases expression

ISO

Gold analog results in decreased expression of ACAD11 mRNA

NCBI chr 8:104,681,346...104,746,559
Ensembl chr 8:104,681,396...104,746,560

G

acyl-CoA dehydrogenase medium chain

decreases expression

ISO

Gold analog results in decreased expression of ACADM mRNA

NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:242,858,865...242,883,147

G

acyl-CoA dehydrogenase short chain

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of ACADS mRNA

NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898

G

acyl-CoA dehydrogenase, very long chain

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of ACADVL mRNA

NCBI chr10:55,231,558...55,236,786
Ensembl chr10:54,732,469...54,738,075

G

aconitase 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of ACO1 mRNA

NCBI chr 5:60,055,895...60,111,920
Ensembl chr 5:55,259,827...55,316,391

G

aconitase 2

decreases expression
multiple interactions

ISO

Gold analog results in decreased expression of ACO2 protein
[Polyethyleneimine binds to Gold] which results in increased expression of ACO2 mRNA

PMID:24780912 PMID:28433809

NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:113,385,646...113,428,261

G

acyl-CoA oxidase 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ACOX1 mRNA

NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,406,197...101,431,232

G

acyl-CoA oxidase 2

decreases expression

ISO

Gold analog results in decreased expression of ACOX2 mRNA

NCBI chr15:19,090,820...19,122,392
Ensembl chr15:16,660,272...16,692,160

G

acid phosphatase 1

decreases expression

ISO

Gold results in decreased expression of ACP1 mRNA

NCBI chr 6:53,233,937...53,249,576
Ensembl chr 6:47,506,380...47,522,021

G

activin A receptor type 1C

decreases expression

ISO

Gold results in decreased expression of ACVR1C mRNA

NCBI chr 3:63,224,322...63,301,252
Ensembl chr 3:42,822,610...42,892,327

G

ADAM metallopeptidase domain 28

increases expression

ISO

Gold results in increased expression of ADAM28 mRNA

NCBI chr15:50,184,286...50,250,605
Ensembl chr15:42,944,467...43,840,672

G

alcohol dehydrogenase 5 (class III), chi polypeptide

decreases expression

ISO

Gold results in decreased expression of ADH5 mRNA

NCBI chr 2:229,648,557...229,660,964
Ensembl chr 2:226,947,466...226,987,591

G

adiponectin receptor 2

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ADIPOR2 mRNA

NCBI chr 4:154,195,440...154,261,141
Ensembl chr 4:152,524,623...152,559,355

G

adrenoceptor alpha 1B

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRA1B mRNA

NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919

G

adrenoceptor beta 2

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of ADRB2 mRNA

NCBI chr18:57,912,760...57,914,802
Ensembl chr18:55,502,903...55,644,512

G

alpha-2-HS-glycoprotein

decreases expression

ISO

Gold analog results in decreased expression of AHSG mRNA

NCBI chr11:91,625,975...91,632,583
Ensembl chr11:78,117,918...78,145,999

G

apoptosis inducing factor, mitochondria associated 1

increases expression

ISO

Gold results in increased expression of AIFM1 protein

NCBI chr X:132,528,107...132,567,237
Ensembl chr X:127,650,226...127,689,256

G

aminoacyl tRNA synthetase complex-interacting multifunctional protein 1

decreases expression

ISO

Gold results in decreased expression of AIMP1 mRNA

NCBI chr 2:223,825,930...223,849,477
Ensembl chr 2:221,151,904...221,175,728

G

adenylate kinase 3

decreases expression

ISO

Gold results in decreased expression of AK3 mRNA

NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625

G

A-kinase anchoring protein 13

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of AKAP13 mRNA

NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646

G

aldo-keto reductase family 1 member B10

increases expression

ISO

Gold results in increased expression of AKR1B10 mRNA

NCBI chr 4:63,038,459...63,060,336
Ensembl chr 4:63,040,169...63,053,852

G

aldo-keto reductase family 1, member C2

increases expression

ISO

Gold results in increased expression of AKR1C2 mRNA

NCBI chr17:70,669,684...70,717,935
Ensembl chr17:65,759,788...65,775,764

G

aldo-keto reductase family 1, member C3

increases expression

ISO

Gold results in increased expression of AKR1C3 mRNA

NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873

G

AKT serine/threonine kinase 1

multiple interactions

ISO

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of AKT1 protein

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

albumin

multiple interactions
increases expression

ISO

ALB protein results in increased uptake of [Polyethylene Glycols binds to Gold]; ALB protein results in increased uptake of [Polyethyleneimine binds to Gold]; ALB protein results in increased uptake of [Thioctic Acid binds to Gold]
Gold analog results in increased expression of ALB mRNA

PMID:28433809 PMID:36057382

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

annexin A5

increases expression

ISO

Gold analog results in increased expression of ANXA5 protein

NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:119,314,007...119,353,369

G

apoptotic peptidase activating factor 1

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of APAF1 mRNA; [Quercetin analog co-treated with Gold analog] results in increased expression of APAF1 protein
Gold analog results in decreased expression of APAF1 mRNA

PMID:27470402 PMID:28433809 PMID:36057382

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540

G

apurinic/apyrimidinic endodeoxyribonuclease 1

decreases expression

ISO

Gold analog results in decreased expression of APEX1 mRNA

NCBI chr15:26,618,146...26,620,330
Ensembl chr15:24,144,362...24,146,785

G

apolipoprotein A4

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of APOA4 mRNA

NCBI chr 8:55,435,779...55,438,160
Ensembl chr 8:46,539,082...46,541,469

G

adenine phosphoribosyl transferase

decreases expression

ISO

Gold analog results in decreased expression of APRT protein

NCBI chr19:67,534,737...67,537,027
Ensembl chr19:50,626,202...50,628,431

G

aquaporin 4

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of AQP4 mRNA

NCBI chr18:6,782,389...6,799,034
Ensembl chr18:6,507,903...6,524,856

G

ARF like GTPase 1

decreases expression

ISO

Gold results in decreased expression of ARL1 mRNA

NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898

G

ARF like GTPase 5B

decreases expression

ISO

Gold results in decreased expression of ARL5B mRNA

NCBI chr17:82,864,315...82,888,458
Ensembl chr17:77,955,818...77,979,854

G

arylsulfatase G

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ARSG mRNA

NCBI chr10:94,412,261...94,551,224
Ensembl chr10:94,447,399...94,542,941

G

N-acylsphingosine amidohydrolase 1

decreases expression

ISO

Gold analog results in decreased expression of ASAH1 mRNA

NCBI chr16:57,669,927...57,701,349
Ensembl chr16:50,966,229...51,008,233

G

activating transcription factor 1

decreases expression

ISO

Gold results in decreased expression of ATF1 mRNA

NCBI chr 7:133,240,774...133,283,488
Ensembl chr 7:131,362,450...131,404,670

G

activating transcription factor 4

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of ATF4 mRNA

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 6

increases cleavage

ISO

Gold analog results in increased cleavage of ATF6 protein

NCBI chr13:85,460,312...85,639,959
Ensembl chr13:82,930,034...83,107,177

G

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

decreases expression

ISO

Gold analog results in decreased expression of ATIC protein

NCBI chr 9:80,614,311...80,634,360
Ensembl chr 9:73,164,846...73,184,889

G

atlastin GTPase 2

decreases expression

ISO

Gold results in decreased expression of ATL2 mRNA

NCBI chr 6:15,139,071...15,180,421
Ensembl chr 6:15,139,044...15,180,421

G

ATM serine/threonine kinase

decreases expression

ISO

Gold analog results in decreased expression of ATM mRNA

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437

G

ATPase plasma membrane Ca2+ transporting 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of ATP2B1 mRNA

NCBI chr 7:33,735,595...33,845,226
Ensembl chr 7:33,735,871...33,843,295

G

ATP synthase F1 subunit beta

multiple interactions

ISO

Gold analog results in increased expression of and results in decreased phosphorylation of ATP5F1B protein

NCBI chr 7:1,100,058...1,106,461
Ensembl chr 7:515,460...567,273

G

ATPase H+ transporting V1 subunit G2

decreases expression

ISO

Gold analog results in decreased expression of ATP6V1G2 mRNA

NCBI chr20:3,592,374...3,595,986
Ensembl chr20:3,587,686...3,590,481

G

ATR serine/threonine kinase

decreases expression

ISO

Gold analog results in decreased expression of ATR mRNA

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:96,426,724...96,524,136

G

beta-secretase 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of BACE1 mRNA

NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:46,142,116...46,165,876

G

BCL2-associated agonist of cell death

multiple interactions

ISO

[Quercetin analog co-treated with Gold analog] results in increased expression of BAD protein

NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823

G

BAR/IMD domain containing adaptor protein 2

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of BAIAP2 mRNA

NCBI chr10:105,721,371...105,788,549
Ensembl chr10:105,223,090...105,290,134

G

BCL2-antagonist/killer 1

increases expression

ISO

Gold results in increased expression of BAK1 mRNA

NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

ISO
EXP

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of BAX protein; [Gold analog co-treated with Platinum] results in increased expression of BAX mRNA; [Polyethyleneimine binds to Gold] which results in decreased expression of BAX mRNA; [Quercetin analog co-treated with Gold analog] results in increased expression of BAX protein
Gold results in increased expression of BAX mRNA
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of BAX protein

PMID:21621595 PMID:22178767 PMID:25846798 PMID:27470402 PMID:27836789 More...

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCAS2, pre-mRNA processing factor

decreases expression

ISO

Gold results in decreased expression of BCAS2 mRNA

NCBI chr 2:190,692,503...190,700,386
Ensembl chr 2:190,692,461...190,700,389

G

BCL2, apoptosis regulator

multiple interactions

ISO
EXP

[Gold analog co-treated with Platinum] results in decreased expression of BCL2 mRNA; [Quercetin analog co-treated with Gold analog] results in decreased expression of BCL2 protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in decreased expression of BCL2 protein

PMID:25846798 PMID:27470402 PMID:27836789

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

Bcl2-like 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of BCL2L1 mRNA

NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479
Ensembl chr 1:141,253,523...141,303,479

G

Bcl2-like 11

decreases expression

ISO

Gold analog results in decreased expression of BCL2L11 mRNA

NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068

G

baculoviral IAP repeat-containing 2

decreases expression

ISO

Gold results in decreased expression of BIRC2 mRNA

NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732

G

baculoviral IAP repeat-containing 3

decreases expression

ISO

Gold analog results in decreased expression of BIRC3 mRNA; Gold results in decreased expression of BIRC3 mRNA

PMID:25523186 PMID:36057382

NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802

G

basic helix-loop-helix ARNT like 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of BMAL1 mRNA

NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:167,331,633...167,430,231

G

BMI1 proto-oncogene, polycomb ring finger

decreases expression

ISO

Gold results in decreased expression of BMI1 mRNA

NCBI chr17:86,240,683...86,250,044
Ensembl chr17:81,332,214...81,388,690

G

BRCA1, DNA repair associated

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA1 mRNA
Gold analog results in decreased expression of BRCA1 mRNA

PMID:28433809 PMID:36057382

NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,418,000...86,477,304

G

BRCA2, DNA repair associated

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of BRCA2 mRNA
Gold analog results in decreased expression of BRCA2 mRNA

PMID:28433809 PMID:36057382

NCBI chr12:4,895,092...4,939,340
Ensembl chr12:59,819...100,567

G

C1D nuclear receptor corepressor

decreases expression

ISO

Gold results in decreased expression of C1D mRNA

NCBI chr14:95,862,550...95,874,796
Ensembl chr14:91,660,989...91,672,852

G

complement C3

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of C3 mRNA

NCBI chr 9:2,174,412...2,201,339
Ensembl chr 9:2,087,437...2,114,429

G

similar to human chromosome 11 open reading frame 54

decreases expression

ISO

Gold results in decreased expression of C11ORF54 mRNA

NCBI chr 8:12,123,839...12,146,412
Ensembl chr 8:12,123,823...12,146,473

G

complement C9

decreases expression

ISO

Gold analog results in decreased expression of C9 mRNA

NCBI chr 2:57,300,510...57,348,759
Ensembl chr 2:55,572,992...55,621,338

G

capping actin protein of muscle Z-line subunit alpha 2

decreases expression

ISO

Gold results in decreased expression of CAPZA2 mRNA

NCBI chr 4:45,978,142...46,014,032
Ensembl chr 4:45,977,807...46,013,864

G

carbonic anhydrase 13

decreases expression

ISO

Gold results in decreased expression of CA13 mRNA

NCBI chr 2:86,928,401...86,959,525
Ensembl chr 2:86,928,383...86,959,525

G

caspase 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of CASP1 mRNA

NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions
increases expression
increases cleavage
increases activity

ISO
EXP

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which results in increased activity of CASP3 protein; [Gold analog co-treated with Platinum] results in increased activity of CASP3 protein; [Gold analog co-treated with Platinum] results in increased expression of CASP3 mRNA; [Polyethyleneimine binds to Gold] which results in increased expression of CASP3 mRNA; [Quercetin analog co-treated with Gold analog] results in increased cleavage of CASP3 protein; [Quercetin analog co-treated with Gold analog] results in increased expression of and results in increased activity of CASP3 protein; Dexamethasone promotes the reaction [Gold results in increased activity of CASP3 protein]; Etoposide promotes the reaction [Gold results in increased activity of CASP3 protein]
Gold results in increased expression of CASP3 mRNA
Gold analog results in increased cleavage of CASP3 protein
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of CASP3 protein

PMID:19760634 PMID:21621595 PMID:22178767 PMID:25846798 PMID:26551149 More...

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 4

increases cleavage

ISO

Gold analog results in increased cleavage of CASP4 protein

NCBI chr 8:10,883,817...10,919,978
Ensembl chr 8:2,598,876...2,635,092

G

caspase 7

increases cleavage

ISO

Gold analog results in increased cleavage of CASP7 protein

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729

G

caspase 8

increases expression
decreases expression

ISO

Gold results in increased expression of CASP8 mRNA
Gold analog results in decreased expression of CASP8 mRNA

PMID:22178767 PMID:36057382

NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

multiple interactions
increases cleavage

ISO
EXP

[Gold analog co-treated with Platinum] results in increased activity of CASP9 protein; [Gold analog co-treated with Platinum] results in increased expression of CASP9 mRNA
[Gold binds to NKCT1 protein, Naja kaouthia] which results in increased expression of CASP9 protein
Gold analog results in increased cleavage of CASP9 protein

PMID:25846798 PMID:26551149 PMID:27836789

Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

ISO

[Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in decreased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

chromobox 3

decreases expression

ISO

Gold results in decreased expression of CBX3 mRNA

NCBI chr 4:80,545,450...80,559,284
Ensembl chr 4:80,546,010...80,559,283
Ensembl chr 4:80,546,010...80,559,283

G

C-C motif chemokine ligand 2

multiple interactions
increases secretion

ISO

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL2 protein
Gold results in increased secretion of CCL2 protein

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 5

multiple interactions
increases secretion

ISO

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL5 protein
Gold results in increased secretion of CCL5 protein

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

multiple interactions
increases secretion

ISO

[Gold co-treated with Silicon Dioxide] results in increased secretion of CCL7 protein
Gold results in increased secretion of CCL7 protein

NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,016,446...67,018,303

G

cyclin D1

multiple interactions

ISO

[Quercetin analog co-treated with Gold analog] results in decreased expression of CCND1 protein

NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602

G

chaperonin containing TCP1 subunit 5

decreases expression

ISO

Gold analog results in decreased expression of CCT5 protein

NCBI chr 2:84,302,621...84,313,773
Ensembl chr 2:82,590,630...82,602,930

G

CD19 molecule

increases expression

ISO

Gold analog results in increased expression of CD19 mRNA

NCBI chr 1:190,417,853...190,424,494
Ensembl chr 1:180,987,286...180,993,975

G

CD36 molecule

decreases expression

ISO

Gold analog results in decreased expression of CD36 mRNA

NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903

G

CD40 molecule

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of CD40 mRNA

NCBI chr 3:174,209,113...174,224,592
Ensembl chr 3:153,790,449...153,805,534

G

CD86 molecule

decreases expression

ISO

Gold analog results in decreased expression of CD86 mRNA

NCBI chr11:77,647,565...77,706,178
Ensembl chr11:64,163,828...64,200,818

G

cytidine deaminase

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CDA mRNA

NCBI chr 5:155,839,929...155,866,541
Ensembl chr 5:150,556,615...150,583,231

G

cyclin-dependent kinase 1

decreases expression
increases expression

ISO

Gold results in decreased expression of CDK1 mRNA
Gold results in increased expression of CDK1 mRNA

PMID:25523186 PMID:29705079

NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 7

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of CDK7 mRNA

NCBI chr 2:33,574,623...33,599,485
Ensembl chr 2:31,840,558...31,865,383

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

ISO

[Gold binds to Dimethyldithiocarbamate] which results in increased expression of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982

G

CDKN2A interacting protein

decreases expression

ISO

Gold results in decreased expression of CDKN2AIP mRNA

NCBI chr16:44,536,147...44,546,216
Ensembl chr16:44,536,234...44,540,033

G

cell growth regulator with ring finger domain 1

decreases expression

ISO

Gold results in decreased expression of CGRRF1 mRNA

NCBI chr15:22,560,902...22,588,815
Ensembl chr15:20,088,571...20,109,037

G

checkpoint kinase 1

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of CHEK1 mRNA
Gold analog results in decreased expression of CHEK1 mRNA

PMID:28433809 PMID:36057382

NCBI chr 8:44,609,417...44,629,867
Ensembl chr 8:36,420,569...36,441,009

G

checkpoint kinase 2

decreases expression

ISO

Gold analog results in decreased expression of CHEK2 mRNA

NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286

G

cysteine and histidine rich domain containing 1

decreases expression

ISO

Gold results in decreased expression of CHORDC1 mRNA

NCBI chr 8:15,374,356...15,398,436
Ensembl chr 8:15,374,471...15,399,162

G

CDGSH iron sulfur domain 1

decreases expression

ISO

Gold results in decreased expression of CISD1 mRNA

NCBI chr20:17,255,302...17,268,688
Ensembl chr20:17,255,151...17,284,924

G

claudin 12

decreases expression

ISO

Gold results in decreased expression of CLDN12 mRNA

NCBI chr 4:28,522,659...28,533,647
Ensembl chr 4:28,522,678...28,533,801

G

CCHC-type zinc finger, nucleic acid binding protein

decreases expression

ISO

Gold results in decreased expression of CNBP mRNA

NCBI chr 4:120,302,768...120,311,694
Ensembl chr 4:120,302,771...120,311,637

G

CCR4-NOT transcription complex, subunit 7

decreases expression

ISO

Gold results in decreased expression of CNOT7 mRNA

NCBI chr16:51,775,416...51,794,581
Ensembl chr16:51,775,412...51,794,576

G

collagen type I alpha 1 chain

increases expression

ISO

Gold analog results in increased expression of COL1A1 protein

NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624

G

collagen type I alpha 2 chain

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of COL1A2 mRNA

NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867

G

collagen type III alpha 1 chain

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of COL3A1 mRNA

NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547

G

COMM domain containing 8

decreases expression

ISO

Gold results in decreased expression of COMMD8 mRNA

NCBI chr14:36,049,040...36,059,617
Ensembl chr14:36,049,004...36,059,617

G

cytochrome c oxidase copper chaperone COX11

decreases expression

ISO

Gold results in decreased expression of COX11 mRNA

NCBI chr10:75,458,735...75,465,322
Ensembl chr10:75,458,749...75,465,322

G

cytochrome c oxidase copper chaperone COX17

decreases expression

ISO

Gold results in decreased expression of COX17 mRNA

NCBI chr11:75,906,245...75,912,036

G

carnitine palmitoyltransferase 1A

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of CPT1A mRNA

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055

G

carnitine palmitoyltransferase 2

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of CPT2 mRNA

NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:122,664,677...122,682,095

G

carnitine O-octanoyltransferase

decreases expression

ISO

Gold analog results in decreased expression of CROT mRNA

NCBI chr 4:26,031,729...26,088,057
Ensembl chr 4:25,080,587...25,133,109

G

colony stimulating factor 2

multiple interactions
increases secretion

ISO

[Gold co-treated with Silicon Dioxide] results in increased secretion of CSF2 protein
Gold results in increased secretion of CSF2 protein

NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 3

increases secretion
multiple interactions

ISO

Gold results in increased secretion of CSF3 protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of CSF3 protein

NCBI chr10:84,157,485...84,159,860
Ensembl chr10:83,661,207...83,663,603

G

CCCTC-binding factor

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CTCF mRNA

NCBI chr19:33,521,726...33,571,124
Ensembl chr19:33,529,319...33,571,123

G

cut-like homeobox 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of CUX1 mRNA

NCBI chr12:25,728,393...26,062,497
Ensembl chr12:20,107,311...20,425,866
Ensembl chr 4:20,107,311...20,425,866

G

C-X-C motif chemokine ligand 10

increases secretion
multiple interactions

ISO

Gold results in increased secretion of CXCL10 protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of CXCL10 protein

NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 2

multiple interactions
increases secretion

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of CXCL2 mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of CXCL2 protein
Gold results in increased secretion of CXCL2 protein

PMID:19695318 PMID:22155353

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of CXCL1 mRNA

NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511

G

cytochrome c, somatic

multiple interactions

ISO

[[Gold results in decreased abundance of Glutathione] which results in increased abundance of Hydrogen Peroxide] which affects the localization of CYCS protein

NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
multiple interactions
decreases expression

ISO

Gold analog results in increased activity of CYP1A1 protein
[Polyethyleneimine binds to Gold] which results in decreased expression of CYP1A1 mRNA
Gold analog results in decreased expression of CYP1A1 mRNA

PMID:20193702 PMID:28433809 PMID:36057382

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 24, subfamily a, polypeptide 1

increases expression

ISO

Gold results in increased expression of CYP24A1 mRNA

NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of CYP2D6 mRNA
Gold analog results in decreased expression of CYP2D6 mRNA

PMID:28433809 PMID:36057382

NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression

ISO

Gold analog results in decreased expression of CYP2E1 mRNA

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450 family 7 subfamily A member 1

increases expression

ISO

Gold analog results in increased expression of CYP7A1 mRNA

NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:19,376,974...19,386,688

G

cytohesin 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of CYTH1 mRNA

NCBI chr10:103,402,727...103,485,826
Ensembl chr10:103,366,145...103,485,760

G

DAB adaptor protein 2

increases expression

ISO

Gold results in increased expression of DAB2 mRNA

NCBI chr 2:57,241,947...57,294,893
Ensembl chr 2:55,514,700...55,567,476

G

decapping mRNA 2

decreases expression

ISO

Gold results in decreased expression of DCP2 mRNA

NCBI chr18:36,750,732...36,787,067
Ensembl chr18:36,750,732...36,788,557

G

dopa decarboxylase

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of DDC mRNA

NCBI chr14:90,592,304...90,682,830
Ensembl chr14:86,378,685...86,469,208

G

DNA-damage inducible transcript 3

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of DDIT4 mRNA

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:27,891,998...27,894,105

G

defensin beta 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of DEFB1 mRNA

NCBI chr16:77,001,326...77,016,068
Ensembl chr16:70,298,863...70,313,604

G

24-dehydrocholesterol reductase

multiple interactions
decreases expression

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of DHCR24 mRNA
Gold analog results in decreased expression of DHCR24 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of DHCR24 mRNA

PMID:19695318 PMID:28433809 PMID:36057382

NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137

G

dihydrolipoamide dehydrogenase

decreases expression

ISO

Gold analog results in decreased expression of DLD mRNA

NCBI chr 6:53,631,686...53,655,059
Ensembl chr 6:47,903,914...47,924,795

G

dynein axonemal heavy chain 14

decreases expression

ISO

Gold results in decreased expression of DNAH14 mRNA

NCBI chr13:93,322,653...93,540,706
Ensembl chr13:93,322,711...93,538,646

G

DnaJ heat shock protein family (Hsp40) member A3

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of DNAJA3 mRNA

NCBI chr10:11,361,168...11,386,599
Ensembl chr10:10,854,732...10,880,161

G

DnaJ heat shock protein family (Hsp40) member B14

decreases expression

ISO

Gold results in decreased expression of DNAJB14 mRNA

NCBI chr 2:229,032,415...229,075,905
Ensembl chr 2:226,358,996...226,402,490

G

DnaJ heat shock protein family (Hsp40) member B6

decreases expression

ISO

Gold results in decreased expression of DNAJB6 mRNA

NCBI chr 4:6,010,081...6,232,052
Ensembl chr 4:5,452,683...5,556,659

G

DnaJ heat shock protein family (Hsp40) member B9

decreases expression

ISO

Gold results in decreased expression of DNAJB9 mRNA

NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063

G

DnaJ heat shock protein family (Hsp40) member C10

decreases expression

ISO

Gold results in decreased expression of DNAJC10 mRNA

NCBI chr 3:65,232,031...65,272,732
Ensembl chr 3:65,232,697...65,272,719

G

DnaJ heat shock protein family (Hsp40) member C19

decreases expression

ISO

Gold results in decreased expression of DNAJC19 mRNA

NCBI chr 2:118,851,497...118,875,813
Ensembl chr 2:116,923,272...116,945,264

G

DnaJ heat shock protein family (Hsp40) member C21

decreases expression

ISO

Gold results in decreased expression of DNAJC21 mRNA

NCBI chr 2:59,419,507...59,446,746
Ensembl chr 2:59,419,510...59,446,752

G

DnaJ heat shock protein family (Hsp40) member C5

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of DNAJC5 mRNA

NCBI chr 3:188,999,508...189,033,455
Ensembl chr 3:168,621,969...168,655,935

G

dihydropyrimidinase-like 4

increases expression

ISO

Gold analog results in increased expression of DPYSL4 mRNA

NCBI chr 1:193,883,039...193,898,916
Ensembl chr 1:193,883,106...193,898,914

G

dopamine receptor D3

multiple interactions

EXP

Gold inhibits the reaction [3-N-methylspiperone binds to DRD3 protein]

NCBI chr11:70,385,586...70,437,793
Ensembl chr11:56,879,689...56,940,596

G

dopamine receptor D4

multiple interactions

EXP

Gold inhibits the reaction [3-N-methylspiperone binds to DRD4 protein]

NCBI chr 1:205,825,937...205,829,124
Ensembl chr 1:196,396,366...196,399,553

G

desmocollin 2

increases expression

ISO

Gold results in increased expression of DSC2 mRNA

NCBI chr18:11,725,466...11,757,591
Ensembl chr18:11,450,390...11,482,392

G

desmoglein 2

increases expression

ISO

Gold results in increased expression of DSG2 mRNA

NCBI chr18:12,121,287...12,179,590
Ensembl chr18:11,846,183...11,904,156

G

dual oxidase 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of DUOX1 mRNA

NCBI chr 3:129,714,125...129,749,186
Ensembl chr 3:109,262,397...109,295,563

G

dual oxidase 2

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of DUOX2 mRNA

NCBI chr 3:129,680,543...129,698,886
Ensembl chr 3:109,226,924...109,245,902

G

dual specificity phosphatase 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646

G

dual specificity phosphatase 11

decreases expression

ISO

Gold results in decreased expression of DUSP11 mRNA

NCBI chr 4:118,367,673...118,385,183
Ensembl chr 4:118,368,053...118,385,181

G

deoxyuridine triphosphatase

decreases expression

ISO

Gold results in decreased expression of DUT mRNA

NCBI chr 3:132,952,258...132,963,433
Ensembl chr 3:112,498,982...112,510,771

G

DAZ interacting zinc finger protein 3

decreases expression

ISO

Gold results in decreased expression of DZIP3 mRNA

NCBI chr11:51,823,235...51,893,353
Ensembl chr11:51,823,231...51,893,353

G

ER degradation enhancing alpha-mannosidase like protein 3

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of EDEM3 mRNA
Gold analog results in decreased expression of EDEM3 mRNA

PMID:28433809 PMID:36057382

NCBI chr13:63,858,282...63,920,538
Ensembl chr13:63,858,716...63,920,523

G

early endosome antigen 1

decreases expression

ISO

Gold results in decreased expression of EEA1 mRNA

NCBI chr 7:30,554,686...30,722,186
Ensembl chr 7:30,554,552...30,718,487

G

eukaryotic translation elongation factor 1 delta

decreases expression

ISO

Gold analog results in decreased expression of EEF1D protein

NCBI chr 7:107,581,930...107,596,735
Ensembl chr 7:107,581,930...107,608,799

G

eukaryotic translation elongation factor 2

decreases expression

ISO

Gold analog results in decreased expression of EEF2 protein

NCBI chr 7:9,183,836...9,196,255
Ensembl chr 7:8,533,116...8,559,183

G

epidermal growth factor

multiple interactions

ISO

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]

NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064

G

epidermal growth factor receptor

multiple interactions

ISO

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]

NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

decreases expression

ISO

Gold analog results in decreased expression of EHHADH mRNA

NCBI chr11:92,746,409...92,779,647
Ensembl chr11:79,241,938...79,275,188

G

EP300 interacting inhibitor of differentiation 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of EID1 mRNA

NCBI chr 3:112,922,961...112,924,680
Ensembl chr 3:112,922,668...112,924,752

G

eukaryotic translation initiation factor 1A, X-linked

decreases expression

ISO

Gold results in decreased expression of EIF1AX mRNA

NCBI chr X:39,307,320...39,322,023
Ensembl chr X:35,498,517...35,513,335

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases phosphorylation

ISO

Gold analog results in increased phosphorylation of EIF2AK3 protein

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911

G

eukaryotic translation initiation factor 4A2

decreases expression

ISO

Gold results in decreased expression of EIF4A2 mRNA

NCBI chr11:77,764,126...77,770,810
Ensembl chr11:77,764,124...77,770,781

G

eukaryotic translation initiation factor 4E

multiple interactions

ISO

[Quercetin analog co-treated with Gold analog] results in decreased expression of EIF4E protein

NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:227,066,673...227,098,683

G

eukaryotic translation initiation factor 4E binding protein 3

multiple interactions

ISO

[Quercetin analog co-treated with Gold analog] results in increased expression of EIF4EBP3 protein

NCBI chr18:28,263,089...28,268,033
Ensembl chr18:28,162,311...28,268,024

G

eukaryotic translation initiation factor 5B

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of EIF5B mRNA
Gold analog results in decreased expression of EIF5B mRNA

PMID:28433809 PMID:36057382

NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482

G

enolase 1

multiple interactions

ISO

Gold analog results in decreased expression of and results in increased phosphorylation of ENO1 protein

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

E1A binding protein p300

multiple interactions

ISO

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased acetylation of and results in increased stability of EP300 protein]; [Polyethyleneimine binds to Gold] which results in decreased expression of EP300 mRNA; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]

PMID:27634460 PMID:28433809

NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088

G

epithelial mitogen

increases expression

ISO

Gold results in increased expression of EPGN mRNA

NCBI chr14:17,360,968...17,369,000
Ensembl chr14:17,076,774...17,084,806

G

Eph receptor A1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of EPHA1 mRNA

NCBI chr 4:72,213,022...72,227,543
Ensembl chr 4:71,246,409...71,260,846

G

epoxide hydrolase 1

increases expression

ISO

Gold analog results in increased expression of EPHX1 mRNA

NCBI chr13:95,246,079...95,275,852
Ensembl chr13:92,714,315...92,790,235

G

ERCC excision repair 2, TFIIH core complex helicase subunit

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of ERCC2 mRNA

NCBI chr 1:88,161,342...88,175,102
Ensembl chr 1:79,033,326...79,047,102

G

ERCC excision repair 6, chromatin remodeling factor

decreases expression

ISO

Gold analog results in decreased expression of ERCC6 mRNA

NCBI chr16:7,771,311...7,841,895
Ensembl chr16:7,765,013...7,835,587

G

endoplasmic reticulum to nucleus signaling 1

increases phosphorylation

ISO

Gold analog results in increased phosphorylation of ERN1 protein

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029

G

endoplasmic reticulum to nucleus signaling 2

increases expression

ISO

Gold analog results in increased expression of ERN2 mRNA

NCBI chr 1:176,726,454...176,743,289
Ensembl chr 1:176,726,454...176,743,289

G

endoplasmic reticulum oxidoreductase 1 alpha

increases expression

ISO

Gold results in increased expression of ERO1A mRNA

NCBI chr15:20,974,771...21,010,170
Ensembl chr15:18,492,945...18,530,478

G

establishment of sister chromatid cohesion N-acetyltransferase 2

decreases expression

ISO

Gold results in decreased expression of ESCO2 mRNA

NCBI chr15:44,210,124...44,230,785
Ensembl chr15:40,034,568...40,055,306
Ensembl chr15:40,034,568...40,055,306

G

estrogen receptor 1

decreases expression

ISO

Gold analog results in decreased expression of ESR1 mRNA

NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002

G

ecotropic viral integration site 5

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of EVI5 mRNA

NCBI chr14:1,875,601...2,021,678
Ensembl chr14:1,875,647...2,021,678

G

even-skipped homeobox 1

increases expression

ISO

Gold results in increased expression of EVX1 mRNA

NCBI chr 4:82,747,192...82,751,569
Ensembl chr 4:81,416,590...81,420,967

G

FA complementation group L

decreases expression

ISO

Gold results in decreased expression of FANCL mRNA

NCBI chr14:104,449,403...104,515,297
Ensembl chr14:100,248,875...100,314,255

G

Fas cell surface death receptor

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of FAS mRNA
Gold analog results in decreased expression of FAS mRNA

PMID:28433809 PMID:36057382

NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591

G

fatty acid synthase

decreases expression

ISO

Gold analog results in decreased expression of FASN mRNA

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261

G

fibroblast growth factor 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of FGF1 mRNA

NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,686,581...30,772,357

G

fumarate hydratase

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of FH mRNA

NCBI chr13:90,056,565...90,082,450
Ensembl chr13:87,524,337...87,550,266

G

FKBP prolyl isomerase 9

increases phosphorylation
decreases expression

ISO

Gold analog results in increased phosphorylation of FKBP9 protein
Gold analog results in decreased expression of FKBP9 protein

NCBI chr 4:86,106,256...86,156,723
Ensembl chr 4:86,106,282...86,156,721

G

flavin containing dimethylaniline monoxygenase 5

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of FMO5 mRNA

NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

ISO

[Gold co-treated with Silicon Dioxide] results in increased expression of FOS mRNA
Gold results in increased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

ferritin heavy chain 1

increases expression

ISO

Gold results in increased expression of FTH1 mRNA

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424

G

FYN binding protein 1

increases expression

ISO

Gold results in increased expression of FYB1 mRNA

NCBI chr 2:55,621,585...55,781,206
Ensembl chr 2:55,632,698...55,779,629

G

frizzled class receptor 4

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of FZD4 mRNA

NCBI chr 1:152,692,507...152,701,372
Ensembl chr 1:143,280,065...143,285,724

G

G2/M-phase specific E3 ubiquitin protein ligase

decreases expression

ISO

Gold results in decreased expression of G2E3 mRNA

NCBI chr 6:68,763,847...68,795,305
Ensembl chr 6:68,764,185...68,793,924

G

polypeptide N-acetylgalactosaminyltransferase 1

decreases expression

ISO

Gold results in decreased expression of GALNT1 mRNA

NCBI chr18:15,489,015...15,568,849
Ensembl chr18:15,489,020...15,568,245

G

polypeptide N-acetylgalactosaminyltransferase 5

decreases expression

ISO

Gold analog results in decreased expression of GALNT5 mRNA

NCBI chr 3:42,573,622...42,619,881
Ensembl chr 3:42,573,622...42,619,881

G

glucosidase, alpha; neutral C

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of GANC mRNA

NCBI chr 3:107,353,369...107,406,104
Ensembl chr 3:107,353,369...107,405,241

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression

ISO

Gold analog results in decreased expression of GAPDH protein

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235

G

grancalcin

decreases expression

ISO

Gold results in decreased expression of GCA mRNA

NCBI chr 3:47,297,320...47,329,913
Ensembl chr 3:47,297,383...47,328,581

G

glutaryl-CoA dehydrogenase

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of GCDH mRNA

NCBI chr19:23,263,215...23,269,689
Ensembl chr19:23,263,264...23,269,681

G

guanine monophosphate synthase

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of GMPS mRNA

NCBI chr 2:150,587,824...150,641,564
Ensembl chr 2:148,435,643...148,485,875

G

G protein subunit gamma 10

decreases expression

ISO

Gold results in decreased expression of GNG10 mRNA

NCBI chr 5:73,856,124...73,863,017
Ensembl chr 5:73,856,164...73,863,012
Ensembl chr 5:73,856,164...73,863,012

G

glutamic-oxaloacetic transaminase 2

decreases expression

ISO

Gold analog results in decreased expression of GOT2 protein

NCBI chr19:9,180,428...9,206,113
Ensembl chr19:9,174,311...9,199,994

G

G protein-coupled receptor 182

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of GPR182 mRNA

NCBI chr 7:63,585,997...63,589,088
Ensembl chr 7:63,578,750...63,589,210

G

glutamic--pyruvic transaminase

multiple interactions
decreases expression

ISO

[Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in increased activity of GPT protein]; [Gold binds to NKCT1 protein, Naja kaouthia] inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]
Gold analog results in decreased expression of GPT mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of GPT mRNA

PMID:27836789 PMID:28433809 PMID:36057382

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 2

increases expression

ISO

Gold analog results in increased expression of GPX2 mRNA; Gold results in increased expression of GPX2 mRNA

PMID:25523186 PMID:36057382

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:95,493,589...95,496,877

G

glutathione peroxidase 3

increases expression

ISO

Gold analog results in increased expression of GPX3 mRNA

NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,028,570...39,037,035

G

gelsolin

decreases expression
increases degradation

ISO

Gold analog results in decreased expression of GSN protein
Gold analog results in increased degradation of GSN protein

PMID:24780912 PMID:26551149

NCBI chr 3:38,982,605...39,035,849
Ensembl chr 3:18,585,172...18,638,402

G

glutathione S-transferase mu 4

multiple interactions
increases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of GSTM4 mRNA
Gold analog results in increased expression of GSTM4 mRNA

PMID:28433809 PMID:36057382

NCBI chr 2:198,356,114...198,373,487
Ensembl chr 2:195,680,004...195,685,323

G

3-hydroxyanthranilate 3,4-dioxygenase

increases expression

ISO

Gold analog results in increased expression of HAAO mRNA

NCBI chr 6:16,598,325...16,617,590
Ensembl chr 6:10,845,771...10,864,877

G

histone acetyltransferase 1

decreases expression

ISO

Gold results in decreased expression of HAT1 mRNA

NCBI chr 3:56,217,344...56,265,021
Ensembl chr 3:56,217,342...56,275,517

G

hepatitis A virus cellular receptor 1

multiple interactions

ISO

[Polyethylene Glycols binds to Gold] which results in increased expression of HAVCR1 protein; [Polyethyleneimine binds to Gold] which results in increased expression of HAVCR1 protein; [Thioctic Acid binds to Gold] which results in increased expression of HAVCR1 protein

NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698

G

hydroxycarboxylic acid receptor 2

increases expression

ISO

Gold results in increased expression of HCAR2 mRNA

NCBI chr12:32,726,252...32,728,238
Ensembl chr12:32,726,184...32,728,504

G

hexosaminidase subunit beta

multiple interactions

EXP

[gold chloride results in increased abundance of Gold] which results in increased export of HEXB protein; [gold tetrachloride, acid results in increased abundance of Gold] which results in increased export of HEXB protein

NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:28,484,012...28,504,223

G

high mobility group box 2

decreases expression

ISO

Gold results in decreased expression of HMGB2 mRNA

NCBI chr16:37,721,374...37,723,950
Ensembl chr16:32,710,658...32,713,140
Ensembl chr 1:32,710,658...32,713,140

G

heme oxygenase 1

increases expression

ISO

Gold results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

homeobox A3

decreases expression

ISO

Gold analog results in decreased expression of HOXA3 mRNA

NCBI chr 4:82,599,860...82,643,831
Ensembl chr 4:81,269,243...81,313,218

G

hypoxanthine phosphoribosyltransferase 1

decreases expression

ISO

Gold results in decreased expression of HPRT1 mRNA

NCBI chr X:137,655,744...137,687,718
Ensembl chr X:132,736,096...132,768,154

G

hemopexin

decreases expression

ISO

Gold analog results in decreased expression of HPX mRNA

NCBI chr 1:169,344,647...169,352,155
Ensembl chr 1:159,932,755...159,940,328

G

heat shock factor binding protein 1

decreases expression

ISO

Gold results in decreased expression of HSBP1 mRNA

NCBI chr19:64,309,703...64,314,035
Ensembl chr19:47,400,966...47,435,821

G

heat shock transcription factor 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of HSF1 mRNA

NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein 90 alpha family class B member 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of HSP90AB1 mRNA

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 13

decreases expression

ISO

Gold results in decreased expression of HSPA13 mRNA

NCBI chr11:27,862,717...27,876,898
Ensembl chr11:14,373,275...14,389,895

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of HSPA1A mRNA

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of HSPA1B mRNA

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 2

decreases expression

ISO

Gold analog results in decreased expression of HSPA2 mRNA

NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:95,128,350...95,131,287

G

heat shock protein family A (Hsp70) member 4

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of HSPA4 mRNA

NCBI chr10:37,908,866...37,951,994
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 8

increases expression

ISO

Gold analog results in increased expression of HSPA8 protein

NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259

G

heat shock protein family A (Hsp70) member 9

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of HSPA9 mRNA

NCBI chr18:26,810,004...26,832,958
Ensembl chr18:26,535,798...26,554,292

G

heat shock protein family B (small) member 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of HSPB1 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of HSPB1 mRNA

PMID:19695318 PMID:28433809

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family D (Hsp60) member 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of HSPD1 mRNA

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:56,579,201...56,589,662

G

HIV-1 Tat interactive protein 2

increases expression

ISO

Gold results in increased expression of HTATIP2 mRNA

NCBI chr 1:108,609,424...108,624,810
Ensembl chr 1:99,469,245...99,488,629

G

HIV-1 Tat specific factor 1

decreases expression

ISO

Gold results in decreased expression of HTATSF1 mRNA

NCBI chr X:139,972,742...139,986,923
Ensembl chr X:134,935,426...134,949,607

G

HtrA serine peptidase 4

decreases expression

ISO

Gold analog results in decreased expression of HTRA4 mRNA

NCBI chr16:67,001,605...67,015,074
Ensembl chr16:67,001,605...67,015,074

G

hypoxia up-regulated 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of HYOU1 mRNA

NCBI chr 8:53,602,882...53,614,998
Ensembl chr 8:44,706,263...44,718,186

G

isocitrate dehydrogenase (NADP(+)) 1

multiple interactions

ISO

Gold analog results in decreased expression of and results in increased phosphorylation of IDH1 protein

NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:66,534,146...66,563,708

G

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of IDH3G mRNA

NCBI chr X:156,666,573...156,675,482
Ensembl chr X:151,515,247...151,524,171

G

interferon gamma receptor 1

increases expression

ISO

Gold results in increased expression of IFNGR1 mRNA

NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:14,333,187...14,351,785

G

insulin-like growth factor 1

multiple interactions

ISO

Gold inhibits the reaction [IGF1 protein binds to IGF1R protein]

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor 1 receptor

multiple interactions

ISO

Gold inhibits the reaction [IGF1 protein binds to IGF1R protein]; Gold inhibits the reaction [IGF2 protein binds to IGF1R protein]

NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777

G

insulin-like growth factor 2

multiple interactions

ISO

Gold inhibits the reaction [IGF2 protein binds to IGF1R protein]

NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:197,814,410...197,823,018

G

IKAROS family zinc finger 2

decreases expression

ISO

Gold results in decreased expression of IKZF2 mRNA

NCBI chr 9:71,046,038...71,191,296
Ensembl chr 9:71,042,440...71,190,867

G

interleukin 10

multiple interactions
increases secretion

ISO

[Gold co-treated with Silicon Dioxide] results in increased secretion of IL10 protein
Gold results in increased secretion of IL10 protein

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 alpha

multiple interactions
increases secretion
decreases expression

ISO

[Gold co-treated with Silicon Dioxide] results in increased secretion of IL1A protein
Gold results in increased secretion of IL1A protein
Gold analog results in decreased expression of IL1A mRNA

PMID:22155353 PMID:36057382

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

multiple interactions
increases secretion
decreases expression

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of IL1B mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of IL1B protein
Gold results in increased secretion of IL1B protein
Gold analog results in decreased expression of IL1B mRNA

PMID:19695318 PMID:22155353 PMID:36057382

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

decreases expression

ISO

Gold analog results in decreased expression of IL4 mRNA

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
increases secretion

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of IL6 mRNA; [Gold co-treated with Silicon Dioxide] results in increased secretion of IL6 protein
Gold results in increased secretion of IL6 protein
[Polyethylene Glycols binds to Gold] which results in increased expression of IL6 protein; [Polyethyleneimine binds to Gold] which results in increased expression of IL6 protein; [Thioctic Acid binds to Gold] which results in increased expression of IL6 protein

PMID:19695318 PMID:22155353 PMID:28433809

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

interleukin 6 receptor

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of IL6RA mRNA

NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:175,298,686...175,347,536

G

inositol monophosphatase 1

decreases expression

ISO

Gold results in decreased expression of IMPA1 mRNA

NCBI chr 2:91,462,781...91,484,057
Ensembl chr 2:91,462,799...91,484,313

G

inositol polyphosphate multikinase

decreases expression

ISO

Gold results in decreased expression of IPMK mRNA

NCBI chr20:17,216,988...17,251,675
Ensembl chr20:17,218,037...17,251,705

G

IQ motif containing GTPase activating protein 2

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of IQGAP2 mRNA

NCBI chr 2:26,894,836...27,170,270
Ensembl chr 2:26,894,825...27,170,279

G

jagged canonical Notch ligand 1

decreases expression

ISO

Gold analog results in decreased expression of JAG1 mRNA

NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:124,406,794...124,442,209

G

Janus kinase 2

multiple interactions

ISO

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of JAK2 protein

NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

ISO

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

junction plakoglobin

decreases expression

ISO

Gold analog results in decreased expression of JUP protein

NCBI chr10:85,800,812...85,827,881
Ensembl chr10:85,300,440...85,327,057

G

ketohexokinase

increases expression

ISO

Gold analog results in increased expression of KHK mRNA

NCBI chr 6:31,165,246...31,175,779
Ensembl chr 6:25,445,300...25,455,717

G

Kin17 DNA and RNA binding protein

decreases expression

ISO

Gold results in decreased expression of KIN mRNA

NCBI chr17:73,323,189...73,333,542
Ensembl chr17:68,413,486...68,423,845

G

KIT ligand

decreases expression

ISO

Gold results in decreased expression of KITLG mRNA

NCBI chr 7:36,782,621...36,863,796
Ensembl chr 7:34,896,053...34,977,214

G

KRR1, small subunit processome component homolog

decreases expression

ISO

Gold results in decreased expression of KRR1 mRNA

NCBI chr 7:47,475,557...47,486,996
Ensembl chr 7:47,475,557...47,486,985

G

kynureninase

increases expression

ISO

Gold results in increased expression of KYNU mRNA

NCBI chr 3:48,188,286...48,338,996
Ensembl chr 3:27,778,772...27,929,488

G

laccase domain containing 1

increases expression

ISO

Gold results in increased expression of LACC1 mRNA

NCBI chr15:52,390,267...52,407,630
Ensembl chr15:52,395,183...52,407,545

G

lactamase, beta 2

decreases expression

ISO

Gold results in decreased expression of LACTB2 mRNA

NCBI chr 5:5,569,080...5,591,843
Ensembl chr 5:5,569,067...5,596,429

G

La ribonucleoprotein 1B

decreases expression

ISO

Gold results in decreased expression of LARP1B mRNA

NCBI chr 2:123,936,057...123,969,254
Ensembl chr 2:123,935,983...123,968,896

G

LIF, interleukin 6 family cytokine

multiple interactions
increases secretion

ISO

[Gold co-treated with Silicon Dioxide] results in increased secretion of LIF protein
Gold results in increased secretion of LIF protein

NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482

G

DNA ligase 4

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which affects the expression of LIG4 mRNA

NCBI chr16:86,220,345...86,228,930
Ensembl chr16:79,518,312...79,527,040

G

LIM domain and actin binding 1

decreases expression

ISO

Gold results in decreased expression of LIMA1 mRNA

NCBI chr 7:132,780,556...132,880,343
Ensembl chr 7:130,901,717...131,001,473

G

lectin, mannose-binding, 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of LMAN1 mRNA

NCBI chr18:59,508,996...59,530,873
Ensembl chr18:59,508,996...59,530,851

G

lamin A/C

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of LMNA mRNA

NCBI chr 2:176,237,564...176,265,301
Ensembl chr 2:173,939,751...173,960,423

G

lamin B1

increases degradation

ISO

Gold analog results in increased degradation of LMNB1 protein

NCBI chr18:50,175,861...50,215,210
Ensembl chr18:50,175,874...50,214,502

G

lysophosphatidylglycerol acyltransferase 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of LPGAT1 mRNA

NCBI chr13:103,294,622...103,365,372
Ensembl chr13:103,294,528...103,362,333

G

LRAT domain containing 1

increases expression

ISO

Gold results in increased expression of LRATD1 mRNA

NCBI chr 6:36,916,969...36,922,143
Ensembl chr 6:36,913,469...36,922,319

G

LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

ISO

Gold results in decreased expression of LSM5 mRNA

NCBI chr 4:85,951,073...85,954,289
Ensembl chr 6:104,652,477...104,654,165
Ensembl chr 4:104,652,477...104,654,165

G

LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated

decreases expression

ISO

Gold results in decreased expression of LSM6 mRNA

NCBI chr19:46,002,592...46,017,152
Ensembl chr13:42,114,032...42,116,484
Ensembl chr19:42,114,032...42,116,484

G

lanosterol synthase

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of LSS mRNA

NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762

G

mitotic arrest deficient 2 like 1

decreases expression

ISO

Gold results in decreased expression of MAD2L1 mRNA

NCBI chr 4:97,236,419...97,247,603
Ensembl chr 4:95,906,817...95,913,470

G

microtubule-associated protein 1B

increases expression

ISO

Gold results in increased expression of MAP1B mRNA

NCBI chr 2:32,551,423...32,644,471
Ensembl chr 2:30,817,261...30,910,317

G

mitogen activated protein kinase kinase 1

multiple interactions

ISO

MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]]

NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147

G

muscleblind-like splicing regulator 2

decreases expression

ISO

Gold results in decreased expression of MBNL2 mRNA

NCBI chr15:97,385,278...97,542,924
Ensembl chr15:97,385,244...97,542,937

G

malate dehydrogenase 1B

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of MDH1B mRNA
Gold analog results in decreased expression of MDH1B mRNA

PMID:28433809 PMID:36057382

NCBI chr 9:65,120,370...65,168,008
Ensembl chr 9:65,119,029...65,167,933

G

MDM2 proto-oncogene

decreases expression

ISO

Gold analog results in decreased expression of MDM2 mRNA

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915

G

mitochondrial trans-2-enoyl-CoA reductase

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of MECR mRNA

NCBI chr 5:144,029,684...144,056,373
Ensembl chr 5:144,029,731...144,055,863

G

MEFV innate immunity regulator, pyrin

increases expression

ISO

Gold results in increased expression of MEFV mRNA

NCBI chr10:12,288,514...12,303,337
Ensembl chr10:11,787,422...11,796,973

G

methionyl aminopeptidase 2

decreases expression

ISO

Gold analog results in decreased expression of METAP2 mRNA; Gold results in decreased expression of METAP2 mRNA

PMID:25523186 PMID:36057382

NCBI chr 7:28,412,429...28,440,458
Ensembl chr 7:28,411,608...28,440,434

G

marker of proliferation Ki-67

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of MKI67 mRNA
Gold analog results in decreased expression of MKI67 mRNA

PMID:28433809 PMID:36057382

NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762

G

membrane magnesium transporter 1

decreases expression

ISO

Gold results in decreased expression of MMGT1 mRNA

NCBI chr X:134,408,463...134,420,798
Ensembl chr X:134,408,466...134,420,729

G

matrix metallopeptidase 3

increases expression

ISO

Gold results in increased expression of MMP3 mRNA

NCBI chr 8:12,925,267...12,938,828
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

multiple interactions

ISO

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 mRNA]; [Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; EP300 protein inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]; MAP2K1 inhibits the reaction [[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased expression of MMP9 protein]]

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

MNAT1 component of CDK activating kinase

decreases expression

ISO

Gold results in decreased expression of MNAT1 mRNA

NCBI chr 6:97,550,566...97,706,598
Ensembl chr 6:91,814,749...91,970,744

G

MOB kinase activator 1B

decreases expression

ISO

Gold results in decreased expression of MOB1B mRNA

NCBI chr14:19,333,058...19,365,845
Ensembl chr14:19,332,459...19,365,845

G

MOB family member 4, phocein

decreases expression

ISO

Gold results in decreased expression of MOB4 mRNA

NCBI chr 9:56,617,374...56,641,336
Ensembl chr 9:56,617,368...56,641,329

G

MORC family CW-type zinc finger 3

decreases expression

ISO

Gold results in decreased expression of MORC3 mRNA

NCBI chr11:33,151,906...33,194,650
Ensembl chr11:33,152,025...33,194,646

G

mitochondrial ribosomal protein L3

decreases expression

ISO

Gold results in decreased expression of MRPL3 mRNA

NCBI chr 8:105,670,184...105,693,544
Ensembl chr 8:105,670,184...105,693,544

G

mitochondrial ribosomal protein S6

decreases expression

ISO

Gold results in decreased expression of MRPS6 mRNA

NCBI chr11:31,295,358...31,348,483
Ensembl chr11:31,295,614...31,348,484

G

metallothionein 1, pseudogene 3

increases expression

ISO

Gold results in increased expression of MT1E mRNA

NCBI chr17:79,695,812...79,696,200
Ensembl chr17:74,786,654...74,787,135

G

metallothionein 2

increases expression

ISO

Gold results in increased expression of MT2A mRNA

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784

G

methylenetetrahydrofolate reductase

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of MTHFR mRNA

NCBI chr 5:163,748,346...163,768,141
Ensembl chr 5:158,465,296...158,483,797

G

myotubularin related protein 6

decreases expression

ISO

Gold results in decreased expression of MTMR6 mRNA

NCBI chr15:34,419,931...34,457,863
Ensembl chr15:34,419,903...34,457,861

G

mechanistic target of rapamycin kinase

multiple interactions

ISO

[Quercetin analog co-treated with Gold analog] results in decreased phosphorylation of MTOR protein

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

G

MTSS I-BAR domain containing 1

increases expression

ISO

Gold results in increased expression of MTSS1 mRNA

NCBI chr 7:92,378,228...92,517,444
Ensembl chr 7:90,488,754...90,627,968

G

microsomal triglyceride transfer protein

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of MTTP mRNA

NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239

G

MYCL proto-oncogene, bHLH transcription factor

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of MYCL mRNA

NCBI chr 5:140,559,843...140,566,704
Ensembl chr 5:135,274,748...135,281,582

G

myoneurin

decreases expression

ISO

Gold results in decreased expression of MYNN mRNA

NCBI chr 2:112,779,654...112,797,188
Ensembl chr 2:112,779,657...112,796,397

G

N-acyl phosphatidylethanolamine phospholipase D

decreases expression

ISO

Gold results in decreased expression of NAPEPLD mRNA

NCBI chr 4:13,360,532...13,398,815
Ensembl chr 4:13,361,006...13,398,748

G

neutral cholesterol ester hydrolase 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of NCEH1 mRNA

NCBI chr 2:112,003,677...112,064,274
Ensembl chr 2:110,074,957...110,135,588

G

NFE2 like bZIP transcription factor 2

increases activity
increases expression

ISO

Gold results in increased activity of NFE2L2 promoter
Gold analog results in increased expression of NFE2L2 mRNA; Gold analog results in increased expression of NFE2L2 protein

PMID:21643505 PMID:36057382

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

decreases expression

ISO

Gold analog results in decreased expression of NFKB1 mRNA

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

NFKB inhibitor delta

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of NFKBID mRNA

NCBI chr 1:85,679,353...85,690,415
Ensembl chr 1:85,680,861...85,690,447

G

NFKB inhibitor zeta

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of NFKBIZ mRNA

NCBI chr11:58,251,720...58,279,767
Ensembl chr11:44,782,676...44,810,723

G

NIPBL, cohesin loading factor

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of NIPBL mRNA

NCBI chr 2:59,126,676...59,314,841
Ensembl chr 2:57,399,445...57,565,899

G

nitric oxide synthase 2

increases expression

ISO

Gold results in increased expression of NOS2 protein

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

NPL4 homolog, ubiquitin recognition factor

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of NPLOC4 mRNA

NCBI chr10:106,152,756...106,208,306
Ensembl chr10:105,654,812...105,709,913

G

nucleophosmin 1

decreases expression

ISO

Gold results in decreased expression of NPM1 mRNA

NCBI chr10:18,245,739...18,255,913
Ensembl chr10:17,739,941...17,751,645
Ensembl chr X:17,739,941...17,751,645

G

NAD(P)H quinone dehydrogenase 1

multiple interactions
increases expression

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of NQO1 mRNA
Gold analog results in increased expression of NQO1 mRNA; Gold results in increased expression of NQO1 mRNA

PMID:28433809 PMID:29705079 PMID:36057382

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 0, group B, member 2

decreases expression

ISO

Gold analog results in decreased expression of NR0B2 mRNA

NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:145,779,294...145,782,609

G

nuclear receptor subfamily 4, group A, member 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of NR4A1 mRNA

NCBI chr 7:134,247,153...134,268,044
Ensembl chr 7:132,374,840...132,389,297

G

neuronal cell adhesion molecule

increases expression

ISO

Gold results in increased expression of NRCAM mRNA

NCBI chr 6:67,129,723...67,425,510
Ensembl chr 6:61,329,863...61,702,992

G

nuclear receptor interacting protein 1

increases expression

ISO

Gold results in increased expression of NRIP1 mRNA

NCBI chr11:28,382,835...28,466,483
Ensembl chr11:14,895,553...14,981,761

G

netrin 4

increases expression

ISO

Gold results in increased expression of NTN4 mRNA

NCBI chr 7:28,186,611...28,300,390
Ensembl chr 7:28,186,611...28,300,390

G

nucleobindin 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of NUCB1 mRNA

NCBI chr 1:95,968,325...95,999,183
Ensembl chr 1:95,968,326...96,003,220

G

nudix hydrolase 1

decreases expression

ISO

Gold analog results in decreased expression of NUDT1 mRNA

NCBI chr12:14,302,514...14,309,559
Ensembl chr12:14,302,694...14,305,826

G

nudix hydrolase 12

decreases expression

ISO

Gold results in decreased expression of NUDT12 mRNA

NCBI chr 9:98,741,627...98,755,039
Ensembl chr 9:98,742,360...98,755,039

G

nudix hydrolase 13

decreases expression

ISO

Gold analog results in decreased expression of NUDT13 mRNA

NCBI chr15:4,001,787...4,022,404
Ensembl chr15:4,001,794...4,022,293

G

nucleoporin 210

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of NUP210 mRNA

NCBI chr 4:123,511,558...123,609,874
Ensembl chr 4:123,511,559...123,609,874

G

ORC ubiquitin ligase 1

decreases expression

ISO

Gold results in decreased expression of OBI1 mRNA

NCBI chr15:87,684,022...87,723,342
Ensembl chr15:81,269,416...81,308,734

G

odr-4 GPCR localization factor homolog

decreases expression

ISO

Gold results in decreased expression of ODR4 mRNA

NCBI chr13:62,369,109...62,424,287
Ensembl chr13:62,394,608...62,424,209

G

oxoglutarate dehydrogenase

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of OGDH mRNA

NCBI chr14:85,363,949...85,431,405
Ensembl chr14:81,150,091...81,217,479

G

8-oxoguanine DNA glycosylase

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of OGG1 mRNA

NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:146,474,750...146,484,766

G

origin recognition complex, subunit 4

decreases expression

ISO

Gold results in decreased expression of ORC4 mRNA

NCBI chr 3:33,290,844...33,334,022
Ensembl chr 3:33,294,355...33,333,824

G

OS9, endoplasmic reticulum lectin

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of OS9 mRNA

NCBI chr 7:62,915,498...62,957,591
Ensembl chr 7:62,915,515...62,943,745

G

oxidative stress induced growth inhibitor 1

increases expression

ISO

Gold results in increased expression of OSGIN1 mRNA

NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516

G

prolyl 4-hydroxylase subunit beta

decreases expression

ISO

Gold analog results in decreased expression of P4HB protein

NCBI chr10:106,335,300...106,346,911
Ensembl chr10:105,836,982...105,848,500

G

poly (ADP-ribose) polymerase 1

multiple interactions
decreases expression

ISO

Organogold Compounds promotes the reaction [Gold binds to PARP1 protein]
Gold analog results in decreased expression of PARP1 mRNA

PMID:21370912 PMID:36057382

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

G

poly(rC) binding protein 1

decreases expression

ISO

Gold analog results in decreased expression of PCBP1 protein

NCBI chr 4:118,972,698...118,974,705
Ensembl chr 4:118,972,661...118,976,500

G

propionyl-CoA carboxylase subunit alpha

decreases expression

ISO

Gold analog results in decreased expression of PCCA mRNA

NCBI chr15:106,034,586...106,374,908
Ensembl chr15:99,627,982...99,968,266

G

polycomb group ring finger 5

decreases expression

ISO

Gold results in decreased expression of PCGF5 mRNA

NCBI chr 1:234,063,854...234,180,022
Ensembl chr 1:234,063,892...234,175,315

G

polycomb group ring finger 6

decreases expression

ISO

Gold results in decreased expression of PCGF6 mRNA

NCBI chr 1:245,925,354...245,944,964
Ensembl chr 1:245,925,360...245,944,914

G

proliferating cell nuclear antigen

decreases expression

ISO

Gold analog results in decreased expression of PCNA mRNA

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995

G

phosphodiesterase 4B

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of PDE4B mRNA

NCBI chr 5:116,799,819...117,369,155
Ensembl chr 5:116,799,971...117,367,696

G

period circadian regulator 3

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of PER3 mRNA

NCBI chr 5:166,740,914...166,778,243
Ensembl chr 5:161,459,533...161,495,607

G

phosphatidylinositol glycan anchor biosynthesis, class A

decreases expression

ISO

Gold results in decreased expression of PIGA mRNA

NCBI chr X:30,043,033...30,055,861
Ensembl chr X:30,042,343...30,055,804

G

phosphatidylinositol glycan anchor biosynthesis, class F

decreases expression

ISO

Gold results in decreased expression of PIGF mRNA

NCBI chr 6:7,589,584...7,617,719
Ensembl chr 6:7,589,570...7,639,675

G

phosphatidylinositol glycan anchor biosynthesis, class K

decreases expression

ISO

Gold results in decreased expression of PIGK mRNA

NCBI chr 2:241,630,021...241,715,493
Ensembl chr 2:241,630,053...241,716,134

G

phosphatidylinositol glycan anchor biosynthesis, class Y

decreases expression

ISO

Gold results in decreased expression of PIGY mRNA

NCBI chr 8:20,689,621...20,691,863
Ensembl chr 8:20,689,502...20,692,585

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of PIK3R1 mRNA

NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631

G

pyruvate kinase M1/2

decreases expression

ISO

Gold analog results in decreased expression of PKM protein

NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:60,057,402...60,079,599

G

phospholipase A2 group VI

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of PLA2G6 mRNA

NCBI chr 7:112,731,803...112,771,978
Ensembl chr 7:110,851,378...110,891,114

G

pleckstrin homology and FYVE domain containing 2

decreases expression

ISO

Gold results in decreased expression of PLEKHF2 mRNA

NCBI chr 5:24,091,077...24,106,758
Ensembl chr 5:24,090,688...24,106,601

G

perilipin 3

increases expression

ISO

Gold analog results in increased expression of PLIN3 protein

NCBI chr 9:1,111,178...1,123,057
Ensembl chr 9:1,102,366...1,123,147

G

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of PMAIP1 mRNA

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:59,986,017...59,992,429

G

DNA polymerase kappa

decreases expression

ISO

Gold results in decreased expression of POLK mRNA

NCBI chr 2:27,822,228...27,882,331
Ensembl chr 2:27,822,679...27,882,313

G

RNA polymerase II, I and III subunit K

decreases expression

ISO

Gold results in decreased expression of POLR2K mRNA

NCBI chr 7:69,241,233...69,244,579
Ensembl chr 7:67,356,113...67,357,668

G

popeye domain cAMP effector 1

increases expression

ISO

Gold results in increased expression of POPDC1 mRNA

NCBI chr20:48,819,241...48,860,282
Ensembl chr20:48,822,308...48,857,472

G

popeye domain cAMP effector 3

increases expression

ISO

Gold results in increased expression of POPDC3 mRNA

NCBI chr20:48,772,397...48,800,677
Ensembl chr20:48,772,462...48,800,593

G

cytochrome p450 oxidoreductase

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of POR mRNA

NCBI chr12:26,587,674...26,655,612
Ensembl chr12:20,951,058...20,999,245

G

protein phosphatase 1 catalytic subunit beta

decreases expression

ISO

Gold results in decreased expression of PPP1CB mRNA

NCBI chr 6:29,681,099...29,712,835
Ensembl chr 6:23,960,998...23,992,824

G

protein phosphatase 2 scaffold subunit A alpha

decreases expression

ISO

Gold analog results in decreased expression of PPP2R1A protein

NCBI chr 1:69,213,198...69,232,441
Ensembl chr 1:60,540,194...60,560,129

G

protein phosphatase 2 regulatory subunit B', epsilon

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of PPP2R5E mRNA

NCBI chr 6:99,904,569...100,053,672
Ensembl chr 6:94,168,846...94,317,872

G

peroxiredoxin 1

decreases expression
increases expression

ISO

Gold analog results in decreased expression of PRDX1 protein
Gold analog results in increased expression of PRDX1 mRNA

PMID:24780912 PMID:36057382

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:130,147,204...130,162,856

G

proline-rich coiled-coil 2A

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of PRRC2A mRNA

NCBI chr20:3,658,391...3,674,143
Ensembl chr20:3,658,695...3,674,130

G

phosphoserine aminotransferase 1

decreases expression

ISO

Gold analog results in decreased expression of PSAT1 protein

NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:213,196,709...213,218,682

G

proteasome 26S subunit, non-ATPase 14

decreases expression

ISO

Gold results in decreased expression of PSMD14 mRNA

NCBI chr 3:66,662,933...66,755,666
Ensembl chr 3:46,254,330...46,347,076

G

polypyrimidine tract binding protein 2

decreases expression

ISO

Gold results in decreased expression of PTBP2 mRNA

NCBI chr 2:207,812,659...207,874,019
Ensembl chr 2:207,812,920...207,873,506

G

prostaglandin reductase 1

increases expression

ISO

Gold results in increased expression of PTGR1 mRNA

NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666

G

prostaglandin reductase 2

decreases expression

ISO

Gold results in decreased expression of PTGR2 mRNA

NCBI chr 6:103,931,367...103,963,113
Ensembl chr 6:103,931,409...103,963,111

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

ISO

[Gold co-treated with Silicon Dioxide] results in increased expression of PTGS2 mRNA
[Polyethyleneimine binds to Gold] which results in decreased expression of PTGS2 mRNA
Gold results in increased expression of PTGS2 mRNA

PMID:22155353 PMID:28433809

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine phosphatase, receptor type, C

increases expression

ISO

Gold analog results in increased expression of PTPRC mRNA

NCBI chr13:52,147,717...52,259,810
Ensembl chr13:49,596,193...49,708,692

G

6-pyruvoyl-tetrahydropterin synthase

decreases expression

ISO

Gold results in decreased expression of PTS mRNA

NCBI chr 8:50,870,838...50,877,869
Ensembl chr 8:50,870,841...50,877,869

G

PVR cell adhesion molecule

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of PVR mRNA

NCBI chr 1:79,561,294...79,576,700
Ensembl chr 1:79,546,879...79,576,715

G

RAB11a, member RAS oncogene family

decreases expression

ISO

Gold results in decreased expression of RAB11A mRNA

NCBI chr 8:74,118,922...74,141,760
Ensembl chr 8:65,222,949...65,246,525

G

RAB18, member RAS oncogene family

decreases expression

ISO

Gold results in decreased expression of RAB18 mRNA

NCBI chr17:54,944,099...54,976,093
Ensembl chr17:54,943,955...54,976,043

G

Rab geranylgeranyltransferase subunit beta

decreases expression

ISO

Gold results in decreased expression of RABGGTB mRNA

NCBI chr 2:242,844,758...242,850,951
Ensembl chr 2:242,844,762...242,851,050

G

RAD51 recombinase

decreases expression

ISO

Gold analog results in decreased expression of RAD51 mRNA

NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:106,100,381...106,125,035

G

RAD51 paralog B

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of RAD51B mRNA

NCBI chr 6:103,829,390...104,373,923
Ensembl chr 6:98,098,868...98,640,979

G

retinoic acid induced 14

increases expression

ISO

Gold results in increased expression of RAI14 mRNA

NCBI chr 2:61,273,439...61,411,141
Ensembl chr 2:59,546,284...59,681,971

G

RB1-inducible coiled-coil 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of RB1CC1 mRNA

NCBI chr 5:17,948,522...18,012,434
Ensembl chr 5:13,161,648...13,225,560

G

RNA binding motif protein 12

decreases expression

ISO

Gold results in decreased expression of RBM12 mRNA

NCBI chr 3:144,609,661...144,629,911
Ensembl chr 3:144,611,623...144,629,915

G

retinol binding protein 1

increases expression

ISO

Gold results in increased expression of RBP1 mRNA

NCBI chr 8:107,904,589...107,926,109
Ensembl chr 8:99,025,206...99,046,743

G

ring finger and CCCH-type domains 1

decreases expression

ISO

Gold results in decreased expression of RC3H1 mRNA

NCBI chr13:75,707,098...75,779,114
Ensembl chr13:73,173,946...73,238,839

G

radixin

decreases expression

ISO

Gold analog results in decreased expression of RDX mRNA

NCBI chr 8:61,275,792...61,348,260
Ensembl chr 8:52,379,494...52,437,678

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

[Gallic Acid binds to Gold] inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

riboflavin kinase

decreases expression

ISO

Gold results in decreased expression of RFK mRNA

NCBI chr 1:214,799,880...214,807,440
Ensembl chr 1:214,799,825...214,807,438
Ensembl chr X:214,799,825...214,807,438

G

ras homolog family member U

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of RHOU mRNA

NCBI chr19:51,641,476...51,651,249
Ensembl chr19:51,641,227...51,650,552

G

ring finger protein 11

decreases expression

ISO

Gold results in decreased expression of RNF11 mRNA

NCBI chr 5:124,212,433...124,243,125
Ensembl chr 5:124,212,445...124,234,750

G

ring finger protein 13

decreases expression

ISO

Gold results in decreased expression of RNF13 mRNA

NCBI chr 2:141,927,887...142,061,801
Ensembl chr 2:141,927,909...142,061,801

G

ring finger protein 138

decreases expression

ISO

Gold results in decreased expression of RNF138 mRNA

NCBI chr18:12,558,430...12,590,849
Ensembl chr18:12,291,590...12,315,930

G

ring finger protein 149

decreases expression

ISO

Gold results in decreased expression of RNF149 mRNA

NCBI chr 9:41,826,825...41,854,381
Ensembl chr 9:41,830,233...41,854,279

G

ring finger protein 2

decreases expression

ISO

Gold results in decreased expression of RNF2 mRNA

NCBI chr13:66,103,943...66,136,038
Ensembl chr13:63,554,862...63,583,099

G

ring finger protein, transmembrane 1

decreases expression

ISO

Gold results in decreased expression of RNFT1 mRNA

NCBI chr10:71,310,052...71,322,507
Ensembl chr10:71,310,104...71,323,778

G

Ro60, Y RNA binding protein

decreases expression

ISO

Gold results in decreased expression of RO60 mRNA

NCBI chr13:58,049,838...58,070,828
Ensembl chr13:55,499,534...55,520,504

G

RP2 activator of ARL3 GTPase

decreases expression

ISO

Gold results in decreased expression of RP2 mRNA

NCBI chr X:1,872,582...1,916,704
Ensembl chr X:1,873,306...1,916,688

G

ribosomal protein S27-like

decreases expression

ISO

Gold results in decreased expression of RPS27L mRNA

NCBI chr 8:67,562,483...67,567,418
Ensembl chr 8:67,562,483...67,567,418
Ensembl chr12:67,562,483...67,567,418
Ensembl chr 2:67,562,483...67,567,418

G

ribosomal protein S6 kinase B1

multiple interactions

ISO

[Quercetin analog co-treated with Gold analog] results in decreased expression of RPS6KB1 protein

NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908

G

RT1 class II, locus Db1

increases expression

ISO

Gold analog results in increased expression of HLA-DRB1 mRNA

NCBI chr20:4,550,594...4,560,182
Ensembl chr20:4,548,666...4,558,258

G

reticulon 4

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of RTN4 mRNA

NCBI chr14:107,651,001...107,698,610
Ensembl chr14:103,449,930...103,497,686

G

secretion associated, Ras related GTPase 1B

decreases expression

ISO

Gold results in decreased expression of SAR1B mRNA

NCBI chr10:36,024,415...36,054,069
Ensembl chr10:36,024,382...36,054,066

G

SAP domain containing ribonucleoprotein

decreases expression

ISO

Gold results in decreased expression of SARNP mRNA

NCBI chr 7:1,251,096...1,305,335
Ensembl chr 7:1,251,098...1,305,332

G

short coiled-coil protein

decreases expression

ISO

Gold results in decreased expression of SCOC mRNA

NCBI chr19:41,564,166...41,593,932
Ensembl chr19:24,659,651...24,693,217

G

sterol carrier protein 2

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of SCP2 mRNA

NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287

G

Sec23 homolog A, COPII coat complex component

decreases expression

ISO

Gold results in decreased expression of SEC23A mRNA

NCBI chr 6:76,658,793...76,706,125
Ensembl chr 6:76,658,427...76,706,035

G

SEC24 homolog A, COPII coat complex component

decreases expression

ISO

Gold results in decreased expression of SEC24A mRNA

NCBI chr10:35,946,901...36,024,353
Ensembl chr10:35,947,031...36,024,353

G

SEL1L family member 3

increases expression

ISO

Gold results in increased expression of SEL1L3 mRNA

NCBI chr14:57,775,515...57,882,076
Ensembl chr14:57,775,501...57,882,644

G

selenoprotein T

decreases expression

ISO

Gold results in decreased expression of SELENOT mRNA

NCBI chr 2:142,804,387...142,821,438
Ensembl chr 2:142,804,405...142,821,427

G

septin 8

decreases expression

ISO

Gold analog results in decreased expression of SEPTIN8 protein

NCBI chr10:37,684,649...37,713,704
Ensembl chr10:37,684,639...37,713,174

G

stress-associated endoplasmic reticulum protein 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of SERP1 mRNA

NCBI chr 2:142,757,254...142,761,243
Ensembl chr 2:142,757,270...142,761,116

G

serpin family E member 1

increases expression

ISO

Gold results in increased expression of SERPINE1 mRNA

NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657

G

serpin family H member 1

decreases expression

ISO

Gold analog results in decreased expression of SERPINH1 protein

NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801

G

SH3 domain-containing kinase-binding protein 1

increases expression

ISO

Gold results in increased expression of SH3KBP1 mRNA

NCBI chr X:38,686,530...39,031,658
Ensembl chr X:34,877,866...35,222,747

G

solute carrier family 25 member 24

decreases expression

ISO

Gold analog results in decreased expression of SLC25A24 protein

NCBI chr 2:196,761,076...196,799,236
Ensembl chr 2:196,761,274...196,799,231

G

SRA stem-loop interacting RNA binding protein

decreases expression

ISO

Gold results in decreased expression of SLIRP mRNA

NCBI chr 6:107,088,760...107,097,791
Ensembl chr 6:107,088,403...107,097,791

G

SNF2 related chromatin remodeling ATPase with DExD box 1

decreases expression

ISO

Gold results in decreased expression of SMARCAD1 mRNA

NCBI chr 4:95,639,722...95,709,055
Ensembl chr 4:94,311,489...94,372,563

G

structural maintenance of chromosomes 4

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of SMC4 mRNA

NCBI chr 2:155,550,262...155,578,695
Ensembl chr 2:153,240,283...153,271,571

G

structural maintenance of chromosomes 6

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of SMC6 mRNA

NCBI chr 6:39,697,810...39,752,275
Ensembl chr 6:33,978,716...34,031,746

G

small nuclear ribonucleoprotein polypeptide B2

decreases expression

ISO

Gold results in decreased expression of SNRPB2 mRNA

NCBI chr 3:130,399,239...130,408,821
Ensembl chr 3:130,399,248...130,408,812

G

sorting nexin 6

decreases expression

ISO

Gold results in decreased expression of SNX6 mRNA

NCBI chr 6:72,230,950...72,274,157
Ensembl chr 6:72,229,870...72,315,911

G

superoxide dismutase 1

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of SOD1 mRNA

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249

G

SP100 nuclear antigen

decreases expression

ISO

Gold results in decreased expression of SP100 mRNA

NCBI chr 9:93,758,975...93,825,068
Ensembl chr 9:86,311,032...86,377,034

G

Sp3 transcription factor

decreases expression

ISO

Gold results in decreased expression of SP3 mRNA

NCBI chr 3:78,219,421...78,272,318
Ensembl chr 3:57,812,075...57,860,342

G

spastin

decreases expression

ISO

Gold results in decreased expression of SPAST mRNA

NCBI chr 6:26,807,220...26,858,456
Ensembl chr 6:21,055,349...21,107,954

G

spermatogenesis associated 2

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of SPATA2 mRNA

NCBI chr 3:176,621,974...176,639,784
Ensembl chr 3:156,202,967...156,211,705

G

sterol regulatory element binding transcription factor 1

multiple interactions
decreases expression

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of SREBF1 mRNA
Gold analog results in decreased expression of SREBF1 mRNA

PMID:28433809 PMID:36057382

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650

G

SREK1-interacting protein 1

decreases expression

ISO

Gold results in decreased expression of SREK1IP1 mRNA

NCBI chr 2:35,975,978...35,999,636
Ensembl chr 2:35,975,989...35,999,636
Ensembl chr 7:35,975,989...35,999,636

G

signal recognition particle 9

decreases expression

ISO

Gold results in decreased expression of SRP9 mRNA

NCBI chr13:93,832,580...93,840,720
Ensembl chr13:93,832,580...93,840,720

G

serine and arginine rich splicing factor 10

decreases expression

ISO

Gold results in decreased expression of SRSF10 mRNA

NCBI chr 5:153,372,307...153,386,520
Ensembl chr 5:148,088,823...148,101,768

G

serine and arginine rich splicing factor 3

decreases expression

ISO

Gold results in decreased expression of SRSF3 mRNA

NCBI chr20:7,091,928...7,101,860
Ensembl chr20:7,091,910...7,101,078

G

serine and arginine rich splicing factor 7

decreases expression

ISO

Gold results in decreased expression of SRSF7 mRNA

NCBI chr 6:20,564,035...20,571,205
Ensembl chr 6:14,811,808...14,818,965

G

signal transducer and activator of transcription 1

multiple interactions
increases expression

ISO

[Gold co-treated with Silicon Dioxide] results in increased expression of STAT1 mRNA
Gold results in increased expression of STAT1 mRNA

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 3

increases expression
multiple interactions

ISO

Gold results in increased expression of STAT3 mRNA
[Gold co-treated with Silicon Dioxide] results in increased expression of STAT3 mRNA

NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057

G

staufen double-stranded RNA binding protein 2

decreases expression

ISO

Gold results in decreased expression of STAU2 mRNA

NCBI chr 5:7,623,528...7,868,206
Ensembl chr 5:2,840,765...3,084,929

G

starch binding domain 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of STBD1 mRNA

NCBI chr14:15,470,452...15,473,857
Ensembl chr14:15,469,582...15,477,443

G

STEAP family member 1

decreases expression

ISO

Gold results in decreased expression of STEAP1 mRNA

NCBI chr 4:28,276,972...28,287,484
Ensembl chr 4:28,276,909...28,287,479

G

serine/threonine kinase 26

decreases expression

ISO

Gold results in decreased expression of STK26 mRNA

NCBI chr X:130,325,064...130,375,674
Ensembl chr X:130,310,885...130,374,291

G

succinate-CoA ligase ADP-forming subunit beta

decreases expression

ISO

Gold analog results in decreased expression of SUCLA2 mRNA; Gold results in decreased expression of SUCLA2 mRNA

PMID:25523186 PMID:36057382

NCBI chr15:55,161,894...55,215,031
Ensembl chr15:48,752,312...48,805,138

G

synaptotagmin 1

decreases expression

ISO

Gold analog results in decreased expression of SYT1 mRNA

NCBI chr 7:45,699,649...46,244,460
Ensembl chr 7:43,815,785...44,357,803

G

synoviolin 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of SYVN1 mRNA

NCBI chr 1:203,339,235...203,346,137
Ensembl chr 1:203,339,619...203,346,152

G

tumor-associated calcium signal transducer 2

increases expression

ISO

Gold results in increased expression of TACSTD2 mRNA

NCBI chr 4:96,707,950...96,709,650
Ensembl chr 4:96,707,951...96,709,650

G

transcriptional adaptor 1

decreases expression

ISO

Gold results in decreased expression of TADA1 mRNA

NCBI chr13:78,632,908...78,646,863
Ensembl chr13:78,632,866...78,647,504

G

TATA-box binding protein associated factor 9b

decreases expression

ISO

Gold results in decreased expression of TAF9B mRNA

NCBI chr X:71,289,290...71,300,142
Ensembl chr X:71,289,290...71,300,604

G

transgelin

decreases expression

ISO

Gold analog results in decreased expression of TAGLN mRNA

NCBI chr 8:55,121,647...55,127,121
Ensembl chr 8:46,222,472...46,230,668

G

TBL1X/Y related 1

decreases expression

ISO

Gold results in decreased expression of TBL1XR1 mRNA

NCBI chr 2:106,718,811...106,857,989
Ensembl chr 2:104,801,721...104,929,055

G

transcription elongation factor A1

decreases expression

ISO

Gold results in decreased expression of TCEA1 mRNA

NCBI chr 5:14,631,454...14,668,769
Ensembl chr 5:14,631,454...14,668,745
Ensembl chr15:14,631,454...14,668,745

G

tryptophan 2,3-dioxygenase

decreases expression

ISO

Gold results in decreased expression of TDO2 mRNA

NCBI chr 2:169,567,656...169,585,586
Ensembl chr 2:167,269,579...167,287,511

G

testis expressed 30

decreases expression

ISO

Gold results in decreased expression of TEX30 mRNA

NCBI chr 9:53,735,512...53,744,672
Ensembl chr 9:46,242,748...46,252,249

G

transcription factor EC

decreases expression

ISO

Gold results in decreased expression of TFEC mRNA

NCBI chr 4:45,106,129...45,180,236
Ensembl chr 4:45,107,641...45,180,236

G

tissue factor pathway inhibitor 2

increases expression

ISO

Gold results in increased expression of TFPI2 mRNA

NCBI chr 4:31,981,786...31,986,707
Ensembl chr 4:31,982,178...31,986,600

G

transforming growth factor, beta 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of TGFB1 mRNA

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

THAP domain containing 1

decreases expression

ISO

Gold results in decreased expression of THAP1 mRNA

NCBI chr16:65,905,348...65,909,942
Ensembl chr16:65,904,230...65,909,942

G

TIA1 cytotoxic granule-associated RNA binding protein

decreases expression

ISO

Gold results in decreased expression of TIA1 mRNA

NCBI chr 4:118,852,765...118,883,252
Ensembl chr 4:118,852,837...118,880,586

G

transketolase

decreases expression

ISO

Gold analog results in decreased expression of TKT protein

NCBI chr16:5,729,381...5,755,170
Ensembl chr16:5,723,762...5,748,698

G

tousled-like kinase 1

increases expression

ISO

Gold results in increased expression of TLK1 mRNA

NCBI chr 3:55,520,559...55,627,580
Ensembl chr 3:55,503,358...55,691,968

G

toll-like receptor 2

increases expression
multiple interactions

ISO

Gold results in increased expression of TLR2 mRNA
Gold promotes the reaction [SAA1 protein binds to TLR2 protein]

NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630

G

transmembrane 4 L six family member 1

increases expression

ISO

Gold results in increased expression of TM4SF1 mRNA

NCBI chr 2:141,456,950...141,466,146
Ensembl chr 2:141,453,310...141,466,146

G

transmembrane p24 trafficking protein 10

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in decreased expression of TMED10 mRNA

NCBI chr 6:110,722,887...110,757,743
Ensembl chr 6:104,991,838...105,026,753

G

tumor necrosis factor

increases secretion
multiple interactions

ISO

Gold results in increased secretion of TNF protein
[Gold co-treated with Silicon Dioxide] results in increased secretion of TNF protein

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

TNF alpha induced protein 3

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of TNFAIP3 mRNA

NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282

G

TNF alpha induced protein 8 like 1

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of TNFAIP8L1 mRNA

NCBI chr 9:988,587...999,342
Ensembl chr 9:988,594...1,002,254

G

TNF receptor superfamily member 10b

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of TNFRSF10A mRNA

NCBI chr15:51,249,883...51,278,091
Ensembl chr15:44,840,386...44,867,467

G

TNF receptor superfamily member 1A

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591

G

TNF superfamily member 10

decreases expression

ISO

Gold analog results in decreased expression of TNFSF10 mRNA

NCBI chr 2:112,136,550...112,155,903
Ensembl chr 2:110,207,916...110,225,135

G

tumor protein p53

increases expression

ISO

Gold analog results in increased expression of TRP53 mRNA

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

tumor protein, translationally-controlled 1

decreases expression

ISO

Gold analog results in decreased expression of TPT1 protein

NCBI chr15:51,156,728...51,159,629
Ensembl chr15:51,146,154...51,159,625

G

tripartite motif-containing 23

decreases expression

ISO

Gold results in decreased expression of TRIM23 mRNA

NCBI chr 2:37,036,193...37,069,024
Ensembl chr 2:35,302,409...35,335,743

G

tRNA methyltransferase 13 homolog

decreases expression

ISO

Gold results in decreased expression of TRMT13 mRNA

NCBI chr 2:207,217,399...207,232,467
Ensembl chr 2:204,533,632...204,546,843

G

TruB pseudouridine synthase family member 1

decreases expression

ISO

Gold results in decreased expression of TRUB1 mRNA

NCBI chr 1:266,518,510...266,559,633
Ensembl chr 1:256,515,562...256,552,814

G

tubulin, alpha 1A

decreases expression

ISO

Gold analog results in decreased expression of TUBA1A protein

NCBI chr 7:131,992,151...131,996,850
Ensembl chr 7:130,081,032...130,196,186

G

tubulin, beta 5 class I

decreases expression

ISO

Gold analog results in decreased expression of TUBB5 protein

NCBI chr20:2,917,577...2,921,726
Ensembl chr20:2,912,778...2,916,940

G

Tu translation elongation factor, mitochondrial

multiple interactions

ISO

Gold analog results in decreased expression of and results in increased phosphorylation of TUFM protein

NCBI chr 1:181,073,788...181,077,395
Ensembl chr 1:181,073,788...181,077,395

G

thioredoxin domain containing 5

multiple interactions

ISO

Gold analog results in decreased expression of and results in increased phosphorylation of TXNDC5 protein

NCBI chr17:26,495,467...26,523,608
Ensembl chr17:26,289,880...26,318,025

G

thioredoxin interacting protein

decreases expression

ISO

Gold analog results in decreased expression of TXNIP mRNA

NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:184,092,991...184,096,886

G

thioredoxin reductase 1

decreases activity
increases expression

EXP
ISO

Gold results in decreased activity of TXNRD1 protein
Gold results in increased expression of TXNRD1 mRNA

PMID:16510263 PMID:20851179 PMID:29705079

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863

G

thioredoxin reductase 2

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in decreased expression of TXNRD2 mRNA

NCBI chr11:96,024,321...96,072,475
Ensembl chr11:82,519,999...82,568,156

G

UDP-N-acetylglucosamine pyrophosphorylase 1 like 1

decreases expression

ISO

Gold analog results in decreased expression of UAP1L1 protein

NCBI chr 3:8,172,335...8,180,505
Ensembl chr 3:8,173,216...8,180,443

G

ubiquitin-like modifier activating enzyme 2

decreases expression

ISO

Gold results in decreased expression of UBA2 mRNA

NCBI chr 1:86,775,239...86,802,685
Ensembl chr 1:86,775,244...86,802,682

G

ubiquitin-conjugating enzyme E2G 2

decreases expression

ISO

Gold analog results in decreased expression of UBE2G2 mRNA

NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447

G

ubiquitin-conjugating enzyme E2H

increases expression

ISO

Gold results in increased expression of UBE2H mRNA

NCBI chr 4:59,802,102...59,897,583
Ensembl chr 4:58,834,674...58,930,156

G

ubiquitin-conjugating enzyme E2N

decreases expression

ISO

Gold results in decreased expression of UBE2N mRNA

NCBI chr 7:32,041,190...32,071,252
Ensembl chr 7:30,154,616...30,184,355

G

ubiquitin-conjugating enzyme E2W

decreases expression

ISO

Gold results in decreased expression of UBE2W mRNA

NCBI chr 5:7,474,039...7,531,526
Ensembl chr 5:2,690,763...2,814,965

G

uncoupling protein 2

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of UCP2 mRNA

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611

G

UDP glucuronosyltransferase family 1 member A1

decreases expression

ISO

Gold analog results in decreased expression of UGT1A1 mRNA

NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465

G

UDP glucuronosyltransferase family 2 member A1

decreases expression

ISO

Gold analog results in decreased expression of UGT2A1 mRNA

NCBI chr14:20,521,018...20,545,934
Ensembl chr14:20,517,951...20,545,531

G

ubiquitin interaction motif containing 1

increases expression
decreases expression

ISO

Gold results in increased expression of UIMC1 mRNA
Gold results in decreased expression of UIMC1 mRNA

NCBI chr17:9,528,923...9,597,967
Ensembl chr17:9,527,794...9,592,799

G

uridine phosphorylase 2

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of UPP2 mRNA

NCBI chr 3:63,681,671...63,726,194
Ensembl chr 3:43,273,048...43,317,417

G

ubiquitin specific peptidase 1

decreases expression

ISO

Gold results in decreased expression of USP1 mRNA

NCBI chr 5:118,703,056...118,714,426
Ensembl chr 5:113,587,564...113,598,932

G

ubiquitin specific peptidase 15

decreases expression

ISO

Gold results in decreased expression of USP15 mRNA

NCBI chr 7:58,756,714...58,848,778
Ensembl chr 7:58,756,872...58,848,721

G

ubiquitin specific peptidase 16

decreases expression

ISO

Gold results in decreased expression of USP16 mRNA

NCBI chr11:26,681,359...26,711,313
Ensembl chr11:26,681,414...26,710,539

G

ubiquitin specific peptidase 33

decreases expression

ISO

Gold results in decreased expression of USP33 mRNA

NCBI chr 2:243,938,958...243,988,424
Ensembl chr 2:241,292,985...241,328,479

G

ubiquitin specific peptidase 5

decreases expression

ISO

Gold analog results in decreased expression of USP5 protein

NCBI chr 4:157,619,663...157,634,681
Ensembl chr 4:157,619,643...157,634,711

G

vinculin

decreases expression

ISO

Gold analog results in decreased expression of VCL protein

NCBI chr15:3,315,069...3,404,891
Ensembl chr15:3,265,815...3,355,606

G

vimentin

increases degradation

ISO

Gold analog results in increased degradation of VIM protein

NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187

G

WW domain binding protein 4

decreases expression

ISO

Gold results in decreased expression of WBP4 mRNA

NCBI chr15:54,862,700...54,890,668
Ensembl chr15:54,862,843...54,890,647

G

WEE1 G2 checkpoint kinase

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of WEE1 mRNA

NCBI chr 1:164,173,681...164,197,688
Ensembl chr 1:164,174,779...164,197,688

G

XPA, DNA damage recognition and repair factor

multiple interactions

ISO

[Polyethyleneimine binds to Gold] which results in increased expression of XPA mRNA

NCBI chr 5:60,431,673...60,475,726
Ensembl chr 5:60,431,673...60,475,726

G

XPC complex subunit, DNA damage recognition and repair factor

decreases expression

ISO

Gold analog results in decreased expression of XPC mRNA

NCBI chr 4:125,550,833...125,578,084
Ensembl chr 4:123,993,666...124,021,010

G

X-ray repair cross complementing 5

decreases expression

ISO

Gold analog results in decreased expression of XRCC5 mRNA

NCBI chr 9:81,404,507...81,493,293
Ensembl chr 9:73,955,216...74,044,018

G

YOD1 deubiquitinase

decreases expression

ISO

Gold results in decreased expression of YOD1 mRNA

NCBI chr13:44,727,319...44,733,933
Ensembl chr13:42,174,820...42,177,205

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma

multiple interactions

ISO

[Gold co-treated with Polyethylene Glycols] results in increased expression of YWHAG mRNA

NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827

G

zinc finger and BTB domain containing 21

decreases expression

ISO

Gold results in decreased expression of ZBTB21 mRNA

NCBI chr11:37,312,337...37,327,040
Ensembl chr11:37,312,378...37,326,996

G

zinc finger and BTB domain containing 41

decreases expression

ISO

Gold results in decreased expression of ZBTB41 mRNA

NCBI chr13:53,591,961...53,622,007
Ensembl chr13:51,042,948...51,065,768

G

zinc finger CCCH-type containing 15

decreases expression

ISO

Gold results in decreased expression of ZC3H15 mRNA

NCBI chr 3:68,744,591...68,764,335
Ensembl chr 3:68,744,604...68,764,333

G

zinc finger CCHC-type containing 10

decreases expression

ISO

Gold results in decreased expression of ZCCHC10 mRNA

NCBI chr10:37,470,628...37,481,027

G

zinc finger CCHC-type containing 9

decreases expression

ISO

Gold results in decreased expression of ZCCHC9 mRNA

NCBI chr 2:23,038,156...23,048,249
Ensembl chr 2:23,038,317...23,048,217

G

zinc finger CCHC-type and RNA binding motif containing 1

decreases expression

ISO

Gold results in decreased expression of ZCRB1 mRNA

NCBI chr 7:124,525,227...124,538,564
Ensembl chr 7:124,524,870...124,571,261

G

zinc finger DHHC-type palmitoyltransferase 17

decreases expression

ISO

Gold results in decreased expression of ZDHHC17 mRNA

NCBI chr 7:46,369,963...46,433,691
Ensembl chr 7:46,369,988...46,433,764

G

zinc finger DHHC-type palmitoyltransferase 20

decreases expression

ISO

Gold results in decreased expression of ZDHHC20 mRNA

NCBI chr15:31,980,057...32,039,006
Ensembl chr15:31,983,155...32,038,989

G

zinc finger AN1-type containing 1

decreases expression

ISO

Gold results in decreased expression of ZFAND1 mRNA

NCBI chr 2:91,444,497...91,457,540
Ensembl chr 2:91,444,508...91,453,246

G

zinc finger AN1-type containing 6

decreases expression

ISO

Gold results in decreased expression of ZFAND6 mRNA

NCBI chr 1:138,581,002...138,652,052
Ensembl chr 1:138,581,002...138,651,939

G

zinc finger protein 277

decreases expression

ISO

Gold results in decreased expression of ZNF277 mRNA

NCBI chr 6:57,383,454...57,512,785
Ensembl chr 6:57,383,951...57,512,765

G

zinc finger protein 422

decreases expression

ISO

Gold results in decreased expression of ZNF22 mRNA

NCBI chr 4:149,885,805...149,893,287
Ensembl chr 4:149,885,600...149,893,257

G

zinc finger FYVE-type containing 16

decreases expression

ISO

Gold results in decreased expression of ZFYVE16 mRNA

NCBI chr 2:23,713,018...23,757,576
Ensembl chr 2:23,713,766...23,756,990

G

zinc metallopeptidase STE24

decreases expression

ISO

Gold results in decreased expression of ZMPSTE24 mRNA

NCBI chr 5:134,627,218...134,660,360
Ensembl chr 5:134,627,229...134,660,110

G

zinc finger RANBP2-type containing 2

decreases expression

ISO

Gold results in decreased expression of ZRANB2 mRNA

NCBI chr 2:249,232,010...249,245,786
Ensembl chr 2:246,573,166...246,586,942

G

zinc finger containing ubiquitin peptidase 1

decreases expression

ISO

Gold results in decreased expression of ZUP1 mRNA

NCBI chr20:30,785,226...30,815,377
Ensembl chr20:30,785,227...30,815,306

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20845
chemical entity	20843
molecular entity	20842
transition element molecular entity	17788
copper group molecular entity	9864
gold molecular entity	617
elemental gold	512
auride(1-)	0
gold cation +	0
gold nanoparticle	1
gold(0) +	512
gold(1+)	0
gold(3+)	0
Path 2
Term	Annotations
CHEBI ontology	20845
subatomic particle	20843
composite particle	20843
hadron	20843
baryon	20843
nucleon	20843
atomic nucleus	20843
atom	20843
metal atom	18382
transition element atom	17922
d-block element atom	17917
copper group element atom	9864
gold atom	617
gold molecular entity	617
elemental gold	512
auride(1-)	0
gold cation +	0
gold nanoparticle	1
gold(0) +	512
gold(1+)	0
gold(3+)	0

paths to the root