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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carbidopa
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Accession:CHEBI:3395 term browser browse the term
Definition:The hydrate of 3-(3,4-dihydroxyphenyl)propanoic acid in which the hydrogens alpha- to the carboxyl group are substituted by hydrazinyl and methyl groups (S-configuration). Carbidopa is a dopa decarboxylase inhibitor, so prevents conversion of levodopa to dopamine. It has no antiparkinson activity by itself, but is used in the management of Parkinson's disease to reduce peripheral adverse effects of levodopa.
Synonyms:exact_synonym: (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid--water (1/1)
 related_synonym: (-)-L-alpha-hydrazino-3,4-dihydroxy-alpha-methylhydrocinnamic acid monohydrate;   (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid hydrate;   (2S)-3-(3,4-dihydroxyphenyl)-2-hydrazinyl-2-methylpropanoic acid monohydrate;   (S)-carbidopa hydrate;   (alphaS)-alpha-hydrazino-3,4-dihydroxy-alpha-methylbenzenepropanoic acid monohydrate;   Formula=C10H16N2O5;   InChI=1S/C10H14N2O4.H2O/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6;/h2-4,12-14H,5,11H2,1H3,(H,15,16);1H2/t10-;/m0./s1;   InChIKey=QTAOMKOIBXZKND-PPHPATTJSA-N;   L-alpha-(3,4-dihydroxybenzyl)-alpha-hydrazinopropionic acid monohydrate;   SMILES=O.C[C@@](Cc1ccc(O)c(O)c1)(NN)C(O)=O;   carbidopa hydrate;   carbidopa monohydrate;   carbidopum monohydricum
 alt_id: CHEBI:212626
 xref: CAS:38821-49-7;   DrugBank:DB00190;   KEGG:D00558
 xref_mesh: MESH:D002230
 xref: PMID:10841799;   Patent:DE2062285;   Patent:DE2062332;   Patent:GB940596;   Patent:US3462536


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  CHEBI ontology 499
    role 499
      chemical role 425
        greenhouse gas 4
          water 2
            hydrate 2
              carbidopa 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 499
    subatomic particle 499
      composite particle 499
        hadron 499
          baryon 499
            nucleon 499
              atomic nucleus 499
                atom 499
                  main group element atom 492
                    p-block element atom 492
                      carbon group element atom 481
                        carbon atom 480
                          organic molecular entity 480
                            heteroorganic entity 476
                              organochalcogen compound 430
                                organooxygen compound 428
                                  carbon oxoacid 368
                                    carboxylic acid 368
                                      monocarboxylic acid 92
                                        carbidopa (anhydrous) 0
                                          carbidopa 0
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