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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbendazim
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Accession:CHEBI:3392 term browser browse the term
Definition:A member of the class of benzimidazoles that is 2-aminobenzimidazole in which the primary amino group is substituted by a methoxycarbonyl group. A fungicide, carbendazim controls Ascomycetes, Fungi Imperfecti, and Basidiomycetes on a wide variety of crops, including bananas, cereals, cotton, fruits, grapes, mushrooms, ornamentals, peanuts, sugarbeet, soybeans, tobacco, and vegetables.
Synonyms:exact_synonym: methyl 1H-benzimidazol-2-ylcarbamate
 related_synonym: 1H-benzimidazol-2-ylcarbamic acid methyl ester;   2-(Methoxy-carbonylamino)-benzimidazol;   2-(methoxycarbonylamino)benzimidazole;   2-benzimidazolecarbamic acid methyl ester;   BMC;   Formula=C9H9N3O2;   InChI=1S/C9H9N3O2/c1-14-9(13)12-8-10-6-4-2-3-5-7(6)11-8/h2-5H,1H3,(H2,10,11,12,13);   InChIKey=TWFZGCMQGLPBSX-UHFFFAOYSA-N;   MBC;   Mecarzole;   SMILES=COC(=O)Nc1nc2ccccc2[nH]1;   carbendazime;   methyl 2-benzimidazolecarbamate;   methyl benzimidazol-2-ylcarbamate
 xref: CAS:10605-21-7;   HMDB:HMDB0031769;   KEGG:C10897
 xref_mesh: MESH:C006698
 xref: PMID:20833408;   PMID:21315898;   PMID:22077925;   PMID:22903170;   PPDB:116;   Patent:US3010968;   Pesticides:carbendazim;   Reaxys:649044;   Wikipedia:Carbendazim


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carbendazim term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abi2 abl-interactor 2 increases expression EXP carbendazim results in increased expression of ABI2 mRNA CTD PMID:22952946 NCBI chr 9:67,234,612...67,284,504
Ensembl chr 9:67,234,303...67,282,600
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression ISO carbendazim results in increased expression of ACACA mRNA CTD PMID:26071454 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Agpat2 1-acylglycerol-3-phosphate O-acyltransferase 2 increases expression ISO carbendazim results in increased expression of AGPAT2 mRNA CTD PMID:26071454 NCBI chr 3:4,044,741...4,055,384
Ensembl chr 3:4,044,542...4,055,806
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
affects localization
ISO AHR protein affects the reaction [carbendazim results in increased expression of CYP1A1 protein]
carbendazim affects the localization of AHR protein
CTD PMID:27286660 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bag1 BAG cochaperone 1 increases expression EXP carbendazim results in increased expression of BAG1 mRNA CTD PMID:22952946 NCBI chr 5:57,254,421...57,267,002
Ensembl chr 5:57,254,421...57,267,002
JBrowse link
G Bcl2l14 BCL2 like 14 increases expression EXP carbendazim results in increased expression of BCL2L14 mRNA CTD PMID:22952946 NCBI chr 4:168,139,964...168,183,726
Ensembl chr 4:168,142,271...168,183,096
JBrowse link
G Casp3 caspase 3 increases activity ISO carbendazim results in increased activity of CASP3 protein CTD PMID:30851412 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Clca2 chloride channel accessory 2 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of CLCA2 mRNA CTD PMID:22382377 NCBI chr 2:250,954,423...250,981,544
Ensembl chr 2:250,954,397...250,981,623
JBrowse link
G Cldn11 claudin 11 multiple interactions EXP [carbendazim co-treated with iprodione] results in decreased expression of CLDN11 protein CTD PMID:28576679 NCBI chr 2:115,823,541...115,836,846
Ensembl chr 2:115,823,538...115,836,846
JBrowse link
G Clu clusterin decreases expression
increases expression
EXP carbendazim results in decreased expression of CLU mRNA
carbendazim results in increased expression of CLU mRNA
CTD PMID:22952946, PMID:27466211 NCBI chr15:42,626,612...42,665,858
Ensembl chr15:42,640,146...42,665,857
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 increases activity
increases expression
ISO carbendazim results in increased activity of CYP19A1 protein
carbendazim results in increased expression of CYP19A1 mRNA
CTD PMID:14691014 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO
EXP
carbendazim results in increased expression of CYP1A1 mRNA; carbendazim results in increased expression of CYP1A1 protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [carbendazim results in increased expression of CYP1A1 protein]; AHR protein affects the reaction [carbendazim results in increased expression of CYP1A1 protein]; salicylamide inhibits the reaction [carbendazim results in increased expression of CYP1A1 protein]
CTD PMID:10103034, PMID:21784029, PMID:27286660 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO carbendazim results in increased expression of CYP1A2 mRNA; carbendazim results in increased expression of CYP1A2 protein CTD PMID:21784029 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 increases expression ISO carbendazim results in increased expression of CYP2B6 mRNA CTD PMID:22310298 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO carbendazim results in decreased activity of CYP2D6 protein CTD PMID:20183062 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 increases expression ISO carbendazim results in increased expression of DGAT1 mRNA CTD PMID:26071454 NCBI chr 7:117,566,363...117,576,735
Ensembl chr 7:117,566,368...117,576,737
JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 increases expression ISO carbendazim results in increased expression of DGAT2 mRNA CTD PMID:26071454 NCBI chr 1:164,113,459...164,143,818
Ensembl chr 1:164,113,459...164,143,818
JBrowse link
G Dpp7 dipeptidylpeptidase 7 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of DPP7 mRNA CTD PMID:22382377 NCBI chr 3:2,569,135...2,573,387
Ensembl chr 3:2,569,135...2,573,387
JBrowse link
G Esr1 estrogen receptor 1 decreases expression EXP carbendazim results in decreased expression of ESR1 mRNA CTD PMID:28576679 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 decreases expression EXP carbendazim results in decreased expression of ESR2 mRNA CTD PMID:28576679 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Fank1 fibronectin type III and ankyrin repeat domains 1 increases expression EXP carbendazim results in increased expression of FANK1 mRNA CTD PMID:22952946 NCBI chr 1:205,842,469...205,954,152
Ensembl chr 1:205,842,489...205,950,371
JBrowse link
G Foxa2 forkhead box A2 increases expression ISO carbendazim results in increased expression of FOXA2 mRNA CTD PMID:26071454 NCBI chr 3:142,383,084...142,387,493
Ensembl chr 3:142,383,278...142,387,481
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP [carbendazim co-treated with iprodione] results in decreased expression of GJA1 protein CTD PMID:28576679 NCBI chr20:37,876,650...37,889,097
Ensembl chr20:37,876,650...37,889,089
JBrowse link
G Ift81 intraflagellar transport 81 decreases expression EXP carbendazim results in decreased expression of IFT81 mRNA CTD PMID:22952946, PMID:27466211 NCBI chr12:39,420,161...39,507,412
Ensembl chr12:39,423,596...39,506,890
JBrowse link
G Il1b interleukin 1 beta increases expression ISO carbendazim results in increased expression of IL1B mRNA; carbendazim results in increased expression of IL1B protein CTD PMID:26071454 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 increases expression ISO carbendazim results in increased expression of IL6 mRNA; carbendazim results in increased expression of IL6 protein CTD PMID:26071454 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Itga5 integrin subunit alpha 5 decreases expression ISO carbendazim results in decreased expression of ITGA5 mRNA CTD PMID:25530041 NCBI chr 7:144,970,444...144,993,652
Ensembl chr 7:144,970,444...144,993,652
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression ISO carbendazim results in decreased expression of ITGB1 mRNA CTD PMID:25530041 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Loxl1 lysyl oxidase-like 1 multiple interactions
increases expression
EXP 2,5-hexanedione promotes the reaction [carbendazim results in increased expression of LOXL1 protein]; [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of LOXL1 mRNA CTD PMID:22382377 NCBI chr 8:63,067,757...63,092,124
Ensembl chr 8:63,067,300...63,092,009
JBrowse link
G Lpl lipoprotein lipase decreases expression ISO carbendazim results in decreased expression of LPL protein CTD PMID:30496565 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
JBrowse link
G Lrrc6 leucine rich repeat containing 6 decreases expression EXP carbendazim results in decreased expression of LRRC6 mRNA CTD PMID:27466211 NCBI chr 7:107,130,402...107,231,507
Ensembl chr 7:107,130,402...107,223,047
JBrowse link
G Macrod1 mono-ADP ribosylhydrolase 1 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] results in decreased expression of MACROD1 mRNA CTD PMID:22382377 NCBI chr 1:222,310,916...222,451,485
Ensembl chr 1:222,310,920...222,451,484
JBrowse link
G Mfap3l microfibril associated protein 3 like increases expression EXP carbendazim results in increased expression of MFAP3L mRNA CTD PMID:22952946 NCBI chr16:32,734,059...32,777,091
Ensembl chr16:32,738,265...32,753,278
JBrowse link
G Mir128-1 microRNA 128-1 increases expression EXP carbendazim results in increased expression of MIR128-1 mRNA CTD PMID:32418910 NCBI chr13:44,916,534...44,916,615
Ensembl chr13:44,916,534...44,916,615
JBrowse link
G Mir423 microRNA 423 increases expression EXP carbendazim results in increased expression of MIR423 mRNA CTD PMID:32418910 NCBI chr10:63,098,366...63,098,444
Ensembl chr10:63,098,360...63,098,453
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO carbendazim results in decreased expression of MMP2 mRNA CTD PMID:25530041 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO carbendazim results in decreased expression of MMP9 mRNA CTD PMID:25530041 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression ISO carbendazim results in increased expression of NFE2L2 protein CTD PMID:30851412 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO carbendazim inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:30,003,429...30,162,095
Ensembl chr 7:30,003,429...30,162,056
JBrowse link
G Pim1 Pim-1 proto-oncogene, serine/threonine kinase increases expression EXP carbendazim results in increased expression of PIM1 mRNA CTD PMID:22952946 NCBI chr20:8,165,423...8,169,557
Ensembl chr20:8,165,307...8,169,555
JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO carbendazim results in decreased expression of PLAU mRNA CTD PMID:25530041 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
JBrowse link
G Ptgds prostaglandin D2 synthase decreases expression EXP carbendazim results in decreased expression of PTGDS mRNA CTD PMID:22952946 NCBI chr 3:2,686,125...2,689,059
Ensembl chr 3:2,686,123...2,689,084
JBrowse link
G Serpine2 serpin family E member 2 increases expression ISO carbendazim results in increased expression of SERPINE2 mRNA CTD PMID:25530041 NCBI chr 9:85,560,852...85,629,410
Ensembl chr 9:85,560,863...85,626,094
JBrowse link
G Shank3 SH3 and multiple ankyrin repeat domains 3 multiple interactions EXP [carbendazim co-treated with 2,5-hexanedione] affects the expression of SHANK3 mRNA CTD PMID:22382377 NCBI chr 7:130,474,278...130,534,679
Ensembl chr 7:130,474,279...130,534,679
JBrowse link
G Sil1 SIL1 nucleotide exchange factor decreases expression EXP carbendazim results in decreased expression of SIL1 mRNA CTD PMID:22952946, PMID:27466211 NCBI chr18:28,067,476...28,302,008
Ensembl chr18:28,067,484...28,301,863
JBrowse link
G Sod3 superoxide dismutase 3 increases expression EXP carbendazim results in increased expression of SOD3 mRNA CTD PMID:27466211 NCBI chr14:60,958,583...60,971,143
Ensembl chr14:60,958,592...60,964,324
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 increases expression ISO carbendazim results in increased expression of SREBF1 mRNA CTD PMID:26071454 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Tbc1d5 TBC1 domain family, member 5 decreases expression EXP carbendazim results in decreased expression of TBC1D5 mRNA CTD PMID:27466211 NCBI chr 9:1,144,641...1,747,732
Ensembl chr 9:1,145,700...1,746,397
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 increases expression ISO carbendazim results in increased expression of TIMP1 mRNA CTD PMID:25530041 NCBI chr  X:1,364,771...1,369,451
Ensembl chr  X:1,364,786...1,369,384
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO carbendazim results in increased expression of TIMP2 mRNA CTD PMID:25530041 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tnp1 transition protein 1 increases expression EXP carbendazim results in increased expression of TNP1 mRNA CTD PMID:28576679 NCBI chr 9:80,294,837...80,295,446
Ensembl chr 9:80,294,840...80,295,446
JBrowse link
G Tnp2 transition protein 2 increases expression EXP carbendazim results in increased expression of TNP2 mRNA CTD PMID:28576679 NCBI chr10:4,953,898...4,954,626
Ensembl chr10:4,953,879...4,954,624
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        biochemical role 19281
          metabolite 19262
            carbendazim 52
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic ester 14073
                                        carbamate ester 7378
                                          carbamate fungicide 165
                                            benzimidazolylcarbamate fungicide 131
                                              carbendazim 52
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.