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G |
Gstp1 |
glutathione S-transferase pi 1 |
multiple interactions |
ISO |
cobamamide inhibits the reaction [GSTP1 protein results in increased metabolism of 1-chloro-2,4-dinitrobenzene-glutathione conjugate] |
CTD |
PMID:23769903 |
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NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases expression multiple interactions |
ISO |
Vitamin B 12 results in decreased expression of ABCB1 mRNA; Vitamin B 12 results in decreased expression of ABCB1 protein Vitamin B 12 inhibits the reaction [Methotrexate results in increased expression of ABCB1 mRNA] |
CTD |
PMID:17982279 |
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NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Abcd4 |
ATP binding cassette subfamily D member 4 |
affects metabolic processing |
ISO |
ABCD4 protein affects the metabolism of Vitamin B 12 |
CTD |
PMID:22922874 |
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NCBI chr 6:108,315,026...108,329,550
Ensembl chr 6:108,315,035...108,329,464
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G |
Acaca |
acetyl-CoA carboxylase alpha |
multiple interactions |
EXP |
[Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with Dietary Fats co-treated with Dietary Sucrose] results in increased expression of ACACA mRNA |
CTD |
PMID:22648174 |
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NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
Vitamin B 12 inhibits the reaction [Dimethylnitrosamine results in increased expression of ACTA2 mRNA] |
CTD |
PMID:18239293 |
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NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
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G |
Aldh2 |
aldehyde dehydrogenase 2 family member |
multiple interactions |
ISO |
[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of ALDH2 protein |
CTD |
PMID:20118189 |
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NCBI chr12:40,466,418...40,498,813
Ensembl chr12:40,466,495...40,498,752
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G |
As3mt |
arsenite methyltransferase |
multiple interactions |
ISO |
Folic Acid promotes the reaction [Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic]]; Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic] |
CTD |
PMID:20049124 |
|
NCBI chr 1:266,482,787...266,514,570
Ensembl chr 1:266,482,858...266,514,569
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G |
Axin1 |
axin 1 |
multiple interactions |
ISO |
[Folic Acid co-treated with Vitamin B 12 co-treated with Betaine co-treated with Choline] results in increased methylation of AXIN1 gene |
CTD |
PMID:16868943 |
|
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
Folic Acid inhibits the reaction [Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP3 mRNA]]; Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP3 mRNA] |
CTD |
PMID:23935743 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp8 |
caspase 8 |
multiple interactions |
EXP |
Folic Acid inhibits the reaction [Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP8 mRNA]]; Vitamin B 12 promotes the reaction [Dietary Fats results in increased expression of CASP8 mRNA] |
CTD |
PMID:23935743 |
|
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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G |
Cat |
catalase |
multiple interactions |
ISO EXP |
[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased activity of CAT protein Vitamin B 12 promotes the reaction [Folic Acid inhibits the reaction [arsenic trioxide results in decreased activity of CAT protein]] |
CTD |
PMID:16214333 PMID:20118189 |
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NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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G |
Cbs |
cystathionine beta synthase |
multiple interactions |
EXP |
[Fatty Acids, Omega-3 co-treated with Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of CBS mRNA; [Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in increased expression of CBS mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of CBS mRNA |
CTD |
PMID:25003120 |
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NCBI chr20:10,361,987...10,386,663
Ensembl chr20:10,361,988...10,386,751
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
EXP |
[Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of CCL2 mRNA |
CTD |
PMID:22648174 |
|
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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G |
Cd40 |
CD40 molecule |
multiple interactions |
ISO |
[Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of CD40 mRNA |
CTD |
PMID:30116142 |
|
NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
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G |
Crp |
C-reactive protein |
multiple interactions |
ISO |
[Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein; [Vitamin E co-treated with Ascorbic Acid co-treated with Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein |
CTD |
PMID:16517955 |
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NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
ISO |
[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate] inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein] |
CTD |
PMID:20118189 |
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NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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G |
Fads1 |
fatty acid desaturase 1 |
multiple interactions |
EXP |
[Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in decreased expression of FADS1 mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in decreased expression of FADS1 mRNA; [Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS1 protein; Folic Acid inhibits the reaction [[Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in decreased expression of FADS1 mRNA]; Folic Acid promotes the reaction [[Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS1 protein]; Vitamin B 12 deficiency promotes the reaction [Folic Acid results in increased activity of FADS1 protein] |
CTD |
PMID:22133376 |
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NCBI chr 1:226,234,034...226,249,118
Ensembl chr 1:226,234,074...226,249,138
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G |
Fads2 |
fatty acid desaturase 2 |
multiple interactions |
EXP |
[Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS2 protein; [Vitamin B 12 deficiency co-treated with Folic Acid] results in decreased activity of FADS2 protein; Folic Acid inhibits the reaction [[Vitamin B 12 deficiency co-treated with Fatty Acids, Omega-3] results in decreased activity of FADS2 protein] |
CTD |
PMID:22133376 |
|
NCBI chr 1:225,906,582...226,152,568
Ensembl chr 1:226,114,413...226,152,524
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G |
Fasn |
fatty acid synthase |
multiple interactions |
EXP |
[Choline co-treated with Betaine co-treated with Vitamin B 12 co-treated with Folic Acid] affects the reaction [[Dietary Fats co-treated with Dietary Sucrose] affects the methylation of FASN promoter] |
CTD |
PMID:22648174 |
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NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
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G |
Folh1 |
folate hydrolase 1 |
multiple interactions |
ISO |
Vitamin B 12 affects the reaction [FOLH1 gene SNP affects the susceptibility to and affects the metabolism of Arsenic] |
CTD |
PMID:29459232 |
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NCBI chr 1:150,323,768...150,395,415
Ensembl chr 1:150,323,768...150,395,415
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G |
Fut2 |
fucosyltransferase 2 |
affects abundance |
ISO |
FUT2 gene polymorphism affects the abundance of Vitamin B 12 |
CTD |
PMID:18776911 |
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NCBI chr 1:101,631,633...101,651,668
Ensembl chr 1:101,631,635...101,651,668
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G |
Gucy1a1 |
guanylate cyclase 1 soluble subunit alpha 1 |
multiple interactions |
ISO |
3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine promotes the reaction [Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] |
CTD |
PMID:22171090 |
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NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918
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G |
Gucy1b1 |
guanylate cyclase 1 soluble subunit beta 1 |
multiple interactions |
ISO |
3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine promotes the reaction [Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]]; Vitamin B 12 results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] |
CTD |
PMID:22171090 |
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NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024
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G |
Hba-a2 |
hemoglobin alpha, adult chain 2 |
affects expression affects glycosylation |
ISO |
Vitamin B 12 affects the expression of HBA1 protein modified form Vitamin B 12 affects the glycosylation of HBA1 protein |
CTD |
PMID:2299304 |
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NCBI chr10:15,589,364...15,590,207
Ensembl chr10:15,589,364...15,590,220
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G |
Il1b |
interleukin 1 beta |
increases methylation multiple interactions |
ISO |
Vitamin B 12 results in increased methylation of IL1B gene [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of IL1B mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased secretion of IL1B protein; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased methylation of IL1B gene |
CTD |
PMID:30116142 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
[Folic Acid co-treated with Vitamin B 12] inhibits the reaction [arsenic trioxide results in increased expression of IL6 protein] |
CTD |
PMID:16214333 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Maob |
monoamine oxidase B |
decreases activity |
ISO |
Vitamin B 12 results in decreased activity of MAOB protein |
CTD |
PMID:7430361 |
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NCBI chr X:6,430,694...6,533,520
Ensembl chr X:6,430,594...6,533,534
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G |
Mat2a |
methionine adenosyltransferase 2A |
multiple interactions |
EXP |
[Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in increased expression of MAT2A mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of MAT2A mRNA; Fatty Acids, Omega-3 promotes the reaction [[Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of MAT2A mRNA] |
CTD |
PMID:25003120 |
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NCBI chr 4:100,297,478...100,303,047
Ensembl chr 4:100,296,075...100,303,080
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G |
Mmachc |
metabolism of cobalamin associated C |
increases metabolic processing affects binding decreases metabolic processing |
ISO |
MMACHC protein results in increased metabolism of Vitamin B 12 Vitamin B 12 analog binds to MMACHC protein; Vitamin B 12 binds to MMACHC protein MMACHC protein mutant form results in decreased metabolism of Vitamin B 12 |
CTD |
PMID:19700356 |
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NCBI chr 5:135,555,587...135,561,723
Ensembl chr 5:135,555,565...135,561,914
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G |
Mthfr |
methylenetetrahydrofolate reductase |
decreases expression multiple interactions |
EXP |
Vitamin B 12 deficiency results in decreased expression of MTHFR mRNA [Folic Acid co-treated with Vitamin B 12 deficiency] results in decreased expression of MTHFR mRNA; Fatty Acids, Omega-3 inhibits the reaction [Vitamin B 12 deficiency results in decreased expression of MTHFR mRNA] |
CTD |
PMID:25003120 |
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NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
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G |
Mtr |
5-methyltetrahydrofolate-homocysteine methyltransferase |
affects binding multiple interactions increases activity |
ISO EXP |
Vitamin B 12 binds to MTR protein [Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in decreased expression of MTR mRNA; Fatty Acids, Omega-3 promotes the reaction [Vitamin B 12 deficiency inhibits the reaction [Fatty Acids, Omega-3 results in increased expression of MTR mRNA]]; Vitamin B 12 deficiency inhibits the reaction [Fatty Acids, Omega-3 results in increased expression of MTR mRNA] Vitamin B 12 results in increased activity of MTR protein |
CTD |
PMID:17477549 PMID:17982279 PMID:25003120 |
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NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
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G |
Pemt |
phosphatidylethanolamine N-methyltransferase |
multiple interactions |
EXP |
[Fatty Acids, Omega-3 co-treated with Vitamin B 12 deficiency] results in increased expression of PEMT mRNA; [Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of PEMT mRNA; Fatty Acids, Omega-3 inhibits the reaction [[Folic Acid co-treated with Vitamin B 12 deficiency] results in increased expression of PEMT mRNA] |
CTD |
PMID:25003120 |
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NCBI chr10:46,339,821...46,404,640
Ensembl chr10:46,339,821...46,404,642
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
[Betaine co-treated with Choline co-treated with Folic Acid co-treated with Methionine co-treated with Vitamin B 12 co-treated with Zinc Sulfate co-treated with Ethanol] results in increased expression of PPARA protein |
CTD |
PMID:20118189 |
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NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
EXP |
[Folic Acid co-treated with Vitamin B 12] inhibits the reaction [Dietary Fats results in decreased expression of PPARG mRNA]; Vitamin B 12 inhibits the reaction [Dietary Fats results in decreased expression of PPARG mRNA] |
CTD |
PMID:23935743 |
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NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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G |
Serpine1 |
serpin family E member 1 |
multiple interactions increases methylation |
ISO |
[Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SERPINE1 mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased methylation of SERPINE1 gene Vitamin B 12 results in increased methylation of SERPINE1 gene |
CTD |
PMID:30116142 |
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NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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G |
Serpinh1 |
serpin family H member 1 |
multiple interactions |
ISO |
Vitamin B 12 inhibits the reaction [Dimethylnitrosamine results in increased expression of SERPINH1 mRNA] |
CTD |
PMID:18239293 |
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NCBI chr 1:164,301,010...164,308,306
Ensembl chr 1:164,301,010...164,308,317
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G |
Tcn2 |
transcobalamin 2 |
multiple interactions |
ISO |
TCN2 protein binds to and results in increased uptake of Vitamin B 12 |
CTD |
PMID:14632784 |
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NCBI chr14:84,173,992...84,189,299
Ensembl chr14:84,174,138...84,189,266
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP ISO |
[Folic Acid co-treated with Vitamin B 12] inhibits the reaction [arsenic trioxide results in increased expression of TNF protein] [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased expression of TNF mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in decreased secretion of TNF protein |
CTD |
PMID:16214333 PMID:30116142 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Mtr |
5-methyltetrahydrofolate-homocysteine methyltransferase |
multiple interactions |
ISO |
[glutathionylcobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form |
CTD |
PMID:26989453 |
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NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
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G |
Gucy1a1 |
guanylate cyclase 1 soluble subunit alpha 1 |
multiple interactions |
ISO |
Hydroxocobalamin results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] |
CTD |
PMID:22171090 |
|
NCBI chr 2:181,045,694...181,103,321
Ensembl chr 2:181,045,703...181,102,918
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G |
Gucy1b1 |
guanylate cyclase 1 soluble subunit beta 1 |
multiple interactions |
ISO |
Hydroxocobalamin results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] |
CTD |
PMID:22171090 |
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NCBI chr 2:180,976,939...181,026,001
Ensembl chr 2:180,976,939...181,026,024
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G |
Mmachc |
metabolism of cobalamin associated C |
affects binding |
ISO |
Hydroxocobalamin binds to MMACHC protein |
CTD |
PMID:19700356 |
|
NCBI chr 5:135,555,587...135,561,723
Ensembl chr 5:135,555,565...135,561,914
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G |
Mtr |
5-methyltetrahydrofolate-homocysteine methyltransferase |
multiple interactions |
ISO |
[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form; Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Glutathione inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione inhibits the reaction [Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Glutathione promotes the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form] |
CTD |
PMID:26989453 |
|
NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP3 protein] |
CTD |
PMID:21237187 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp7 |
caspase 7 |
multiple interactions |
ISO |
mecobalamin inhibits the reaction [Homocysteine results in increased activity of CASP7 protein] |
CTD |
PMID:21237187 |
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NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
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G |
Mtr |
5-methyltetrahydrofolate-homocysteine methyltransferase |
multiple interactions increases activity |
ISO |
Aluminum inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Arsenic inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Buthionine Sulfoximine inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Lead inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; mecobalamin inhibits the reaction [Buthionine Sulfoximine inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]]; Mercury inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form]; Thimerosal inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form] |
CTD |
PMID:26989453 |
|
NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
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