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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:glucuronic acids
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Accession:CHEBI:33886 term browser browse the term
Synonyms:cyclic_relationship: is_conjugate_acid_of CHEBI:33903



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acetaminophen O-beta-D-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP-binding cassette, sub-family C member 3 increases activity
affects export
multiple interactions
ISO
EXP
acetaminophen glucuronide results in increased activity of ABCC3 protein
ABCC3 protein affects the export of acetaminophen glucuronide
Ethinyl Estradiol promotes the reaction [ABCC3 protein results in increased secretion of acetaminophen glucuronide]
CTD PMID:16250050 PMID:16554369 PMID:17569508 NCBI chr11:94,234,121...94,283,843
Ensembl chr11:94,234,121...94,283,823
JBrowse link
G Ins2 insulin II increases abundance ISO INS protein results in increased abundance of acetaminophen glucuronide CTD PMID:26739624 NCBI chr 7:142,232,393...142,233,463
Ensembl chr 7:142,232,393...142,297,118
JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) multiple interactions EXP OGT gene mutant form inhibits the reaction [Acetaminophen results in increased abundance of acetaminophen glucuronide] CTD PMID:29325178 NCBI chr  X:100,683,617...100,727,957
Ensembl chr  X:100,683,666...100,727,957
JBrowse link
androsterone 3-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kl klotho multiple interactions EXP androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 NCBI chr 5:150,876,072...150,917,282
Ensembl chr 5:150,876,072...150,917,282
JBrowse link
D-glucurono-6,3-lactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO glucuronolactone results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
glucuronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1, member A1 increases reduction ISO AKR1A1 protein results in increased reduction of Glucuronic Acid CTD PMID:10510318 PMID:29763686 NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877
JBrowse link
mono(glucosyluronic acid)bilirubin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP-binding cassette, sub-family member 2 increases expression
affects transport
ISO
EXP
bilirubin glucuronate results in increased expression of ABCC2 mRNA
ABCC2 protein affects the transport of bilirubin glucuronate
CTD PMID:11897625 PMID:16611851 NCBI chr19:43,770,747...43,826,771
Ensembl chr19:43,770,631...43,829,179
JBrowse link
G Por cytochrome p450 oxidoreductase increases abundance EXP POR gene mutant form results in increased abundance of bilirubin glucuronate CTD PMID:25147274 NCBI chr 5:135,698,894...135,764,180
Ensembl chr 5:135,698,887...135,764,180
JBrowse link
UDP-alpha-D-glucuronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP-binding cassette, sub-family B member 11 multiple interactions ISO [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of diosbulbin B] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A analog] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]] CTD PMID:35101544 NCBI chr 2:69,068,626...69,172,960
Ensembl chr 2:69,068,626...69,172,958
JBrowse link
G B3gat3 beta-1,3-glucuronyltransferase 3 affects binding
multiple interactions
ISO B3GAT3 protein binds to Uridine Diphosphate Glucuronic Acid
Uridine Diphosphate Glucuronic Acid inhibits the reaction [Diacetyl results in decreased activity of B3GAT3 protein]
CTD PMID:11986319 NCBI chr19:8,897,740...8,904,600
Ensembl chr19:8,897,738...8,904,600
JBrowse link
G Gale galactose-4-epimerase, UDP affects binding ISO Uridine Diphosphate Glucuronic Acid binds to GALE protein CTD PMID:25526675 NCBI chr 4:135,690,550...135,695,489
Ensembl chr 4:135,691,038...135,695,489
JBrowse link
G Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha increases expression ISO Uridine Diphosphate Glucuronic Acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 5:51,611,591...52,273,316
Ensembl chr 5:51,611,592...51,725,068
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase 1 family, polypeptide A1 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with UGT1A1 protein] results in increased glucuronidation of Labetalol CTD PMID:18098064 NCBI chr 1:88,139,681...88,147,724
Ensembl chr 1:88,139,681...88,146,719
JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with UGT1A3 protein] results in increased metabolism of Lithocholic Acid CTD PMID:36473578 NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719
JBrowse link
G Ugt2b34 UDP glucuronosyltransferase 2 family, polypeptide B34 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol; [Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased metabolism of hyodeoxycholic acid; Fluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol] CTD PMID:18098064 PMID:36473578 NCBI chr 5:87,037,613...87,054,805
Ensembl chr 5:87,037,626...87,054,796
JBrowse link
G Uxs1 UDP-glucuronate decarboxylase 1 multiple interactions ISO [Uridine Diphosphate Glucuronic Acid co-treated with NAD] binds to UXS1 protein CTD PMID:25526675 NCBI chr 1:43,786,121...43,866,999
Ensembl chr 1:43,786,126...43,866,960
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22188
    role 22173
      chemical role 21415
        donor 20250
          Bronsted acid 20117
            oxoacid 20084
              carbon oxoacid 19561
                carboxylic acid 19557
                  monocarboxylic acid 18919
                    uronic acid 16
                      hexuronic acid 16
                        glucuronic acids 15
                          (glucosyluronic acid)bilirubin + 2
                          1-O-all-trans-retinoyl-beta-glucuronic acid 0
                          1-phospho-alpha-D-glucuronic acid 0
                          2-(beta-D-glucopyranosyluronic acid)-D-glucuronic acid 0
                          4,5-dehydro-D-glucuronic acid + 0
                          5-deoxy-D-glucuronic acid 0
                          9-cis-retinoyl-beta-D-glucuronide 0
                          beta-D-GlcpA-(1->3)-beta-D-Galp + 0
                          beta-D-GlcpA-(1->3)-beta-D-Galp-(1->3)-beta-D-Galp-(1->4)-beta-D-Xylp 0
                          beta-D-GlcpA-(1->3)-beta-D-GalpNAc4S 0
                          beta-D-GlcpA-(1->3)-beta-D-GalpNAc6S 0
                          glucuronic acid + 13
                          heparosan-N-sulfate D-glucuronic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22188
    subatomic particle 22180
      composite particle 22180
        hadron 22180
          baryon 22180
            nucleon 22180
              atomic nucleus 22180
                atom 22180
                  main group element atom 22114
                    p-block element atom 22114
                      carbon group element atom 21915
                        carbon atom 21840
                          organic molecular entity 21840
                            organic group 20283
                              organic divalent group 20165
                                organodiyl group 20165
                                  carbonyl group 20159
                                    carbonyl compound 20159
                                      carboxylic acid 19557
                                        monocarboxylic acid 18919
                                          uronic acid 16
                                            hexuronic acid 16
                                              glucuronic acids 15
                                                (glucosyluronic acid)bilirubin + 2
                                                1-O-all-trans-retinoyl-beta-glucuronic acid 0
                                                1-phospho-alpha-D-glucuronic acid 0
                                                2-(beta-D-glucopyranosyluronic acid)-D-glucuronic acid 0
                                                4,5-dehydro-D-glucuronic acid + 0
                                                5-deoxy-D-glucuronic acid 0
                                                9-cis-retinoyl-beta-D-glucuronide 0
                                                beta-D-GlcpA-(1->3)-beta-D-Galp + 0
                                                beta-D-GlcpA-(1->3)-beta-D-Galp-(1->3)-beta-D-Galp-(1->4)-beta-D-Xylp 0
                                                beta-D-GlcpA-(1->3)-beta-D-GalpNAc4S 0
                                                beta-D-GlcpA-(1->3)-beta-D-GalpNAc6S 0
                                                glucuronic acid + 13
                                                heparosan-N-sulfate D-glucuronic acid 0
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