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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:glucuronic acids
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Accession:CHEBI:33886 term browser browse the term
Synonyms:cyclic_relationship: is_conjugate_acid_of CHEBI:33903


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acetaminophen O-beta-D-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC3 ATP binding cassette subfamily C member 3 increases activity
affects export
multiple interactions		 EXP
ISO		 acetaminophen glucuronide results in increased activity of ABCC3 protein
ABCC3 protein affects the export of acetaminophen glucuronide
Ethinyl Estradiol promotes the reaction [ABCC3 protein results in increased secretion of acetaminophen glucuronide]		 CTD PMID:16250050 PMID:16554369 PMID:17569508 NCBI chr17:50,634,881...50,692,253
Ensembl chr17:50,634,777...50,692,253 		JBrowse link
G INS insulin increases abundance EXP INS protein results in increased abundance of acetaminophen glucuronide CTD PMID:26739624 NCBI chr11:2,159,779...2,161,209
Ensembl chr11:2,159,779...2,161,221 		JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase multiple interactions ISO OGT gene mutant form inhibits the reaction [Acetaminophen results in increased abundance of acetaminophen glucuronide] CTD PMID:29325178 NCBI chr  X:71,533,104...71,575,892
Ensembl chr  X:71,533,087...71,575,892 		JBrowse link
androsterone 3-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KL klotho multiple interactions ISO androsterone glucuronide inhibits the reaction [KL protein results in increased hydrolysis of Glucuronides] CTD PMID:14701853 NCBI chr13:33,016,243...33,066,143
Ensembl chr13:33,016,423...33,066,143 		JBrowse link
D-glucurono-6,3-lactone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARGC1A PPARG coactivator 1 alpha increases expression EXP glucuronolactone results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
glucuronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1A1 aldo-keto reductase family 1 member A1 increases reduction EXP
ISO		 AKR1A1 protein results in increased reduction of Glucuronic Acid CTD PMID:10510318 PMID:29763686 NCBI chr 1:45,550,826...45,570,049
Ensembl chr 1:45,550,543...45,570,049 		JBrowse link
mono(glucosyluronic acid)bilirubin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 increases expression
affects transport		 ISO bilirubin glucuronate results in increased expression of ABCC2 mRNA
ABCC2 protein affects the transport of bilirubin glucuronate		 CTD PMID:11897625 PMID:16611851 NCBI chr10:99,782,640...99,852,594
Ensembl chr10:99,782,640...99,852,594 		JBrowse link
G POR cytochrome p450 oxidoreductase increases abundance ISO POR gene mutant form results in increased abundance of bilirubin glucuronate CTD PMID:25147274 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855 		JBrowse link
UDP-alpha-D-glucuronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 multiple interactions EXP [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of diosbulbin B] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A analog] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]]; [NADP co-treated with Uridine Diphosphate Glucuronic Acid co-treated with Phosphoadenosine Phosphosulfate] promotes the reaction [[Enzymes and Coenzymes results in increased metabolism of saikogenin A] inhibits the reaction [ABCB11 protein results in increased transport of Taurodeoxycholic Acid]] CTD PMID:35101544 NCBI chr 2:168,915,390...169,031,324
Ensembl chr 2:168,915,498...169,031,324 		JBrowse link
G B3GAT3 beta-1,3-glucuronyltransferase 3 affects binding
multiple interactions		 EXP B3GAT3 protein binds to Uridine Diphosphate Glucuronic Acid
Uridine Diphosphate Glucuronic Acid inhibits the reaction [Diacetyl results in decreased activity of B3GAT3 protein]		 CTD PMID:11986319 NCBI chr11:62,615,296...62,621,986
Ensembl chr11:62,615,296...62,622,154 		JBrowse link
G GALE UDP-galactose-4-epimerase affects binding EXP Uridine Diphosphate Glucuronic Acid binds to GALE protein CTD PMID:25526675 NCBI chr 1:23,795,599...23,800,754
Ensembl chr 1:23,795,599...23,800,781 		JBrowse link
G PPARGC1A PPARG coactivator 1 alpha increases expression EXP Uridine Diphosphate Glucuronic Acid results in increased expression of PPARGC1A mRNA CTD PMID:23056435 NCBI chr 4:23,792,021...24,472,905
Ensembl chr 4:23,755,041...23,904,089 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 multiple interactions EXP [Uridine Diphosphate Glucuronic Acid co-treated with UGT1A1 protein] results in increased glucuronidation of Labetalol CTD PMID:18098064 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G UGT1A3 UDP glucuronosyltransferase family 1 member A3 multiple interactions EXP [Uridine Diphosphate Glucuronic Acid co-treated with UGT1A3 protein] results in increased metabolism of Lithocholic Acid CTD PMID:36473578 NCBI chr 2:233,729,042...233,773,300
Ensembl chr 2:233,729,042...233,773,300 		JBrowse link
G UGT2B7 UDP glucuronosyltransferase family 2 member B7 multiple interactions EXP [Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol; [Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased metabolism of hyodeoxycholic acid; Fluconazole inhibits the reaction [[Uridine Diphosphate Glucuronic Acid co-treated with UGT2B7 protein] results in increased glucuronidation of Labetalol] CTD PMID:18098064 PMID:36473578 NCBI chr 4:69,051,375...69,112,987
Ensembl chr 4:69,051,363...69,112,987 		JBrowse link
G UXS1 UDP-glucuronate decarboxylase 1 multiple interactions EXP [Uridine Diphosphate Glucuronic Acid co-treated with NAD] binds to UXS1 protein CTD PMID:25526675 NCBI chr 2:106,093,311...106,194,301
Ensembl chr 2:106,093,308...106,194,301 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      chemical role 24242
        donor 23222
          Bronsted acid 23023
            oxoacid 22975
              carbon oxoacid 22749
                carboxylic acid 22729
                  monocarboxylic acid 21724
                    uronic acid 16
                      hexuronic acid 16
                        glucuronic acids 15
                          (glucosyluronic acid)bilirubin + 2
                          1-O-all-trans-retinoyl-beta-glucuronic acid 0
                          1-phospho-alpha-D-glucuronic acid 0
                          2-(beta-D-glucopyranosyluronic acid)-D-glucuronic acid 0
                          4,5-dehydro-D-glucuronic acid + 0
                          5-deoxy-D-glucuronic acid 0
                          9-cis-retinoyl-beta-D-glucuronide 0
                          beta-D-GlcpA-(1->3)-beta-D-Galp + 0
                          beta-D-GlcpA-(1->3)-beta-D-Galp-(1->3)-beta-D-Galp-(1->4)-beta-D-Xylp 0
                          beta-D-GlcpA-(1->3)-beta-D-GalpNAc4S 0
                          beta-D-GlcpA-(1->3)-beta-D-GalpNAc6S 0
                          glucuronic acid + 13
                          heparosan-N-sulfate D-glucuronic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            heteroorganic entity 24766
                              organochalcogen compound 24378
                                organooxygen compound 24054
                                  carbon oxoacid 22749
                                    carboxylic acid 22729
                                      monocarboxylic acid 21724
                                        uronic acid 16
                                          hexuronic acid 16
                                            glucuronic acids 15
                                              (glucosyluronic acid)bilirubin + 2
                                              1-O-all-trans-retinoyl-beta-glucuronic acid 0
                                              1-phospho-alpha-D-glucuronic acid 0
                                              2-(beta-D-glucopyranosyluronic acid)-D-glucuronic acid 0
                                              4,5-dehydro-D-glucuronic acid + 0
                                              5-deoxy-D-glucuronic acid 0
                                              9-cis-retinoyl-beta-D-glucuronide 0
                                              beta-D-GlcpA-(1->3)-beta-D-Galp + 0
                                              beta-D-GlcpA-(1->3)-beta-D-Galp-(1->3)-beta-D-Galp-(1->4)-beta-D-Xylp 0
                                              beta-D-GlcpA-(1->3)-beta-D-GalpNAc4S 0
                                              beta-D-GlcpA-(1->3)-beta-D-GalpNAc6S 0
                                              glucuronic acid + 13
                                              heparosan-N-sulfate D-glucuronic acid 0
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