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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbamazepine-10,11-epoxide
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Accession:CHEBI:3388 term browser browse the term
Definition:An epoxide and metabolite of carbamazepine.
Synonyms:exact_synonym: 1a,10b-dihydro-6H-dibenzo[b,f]oxireno[d]azepine-6-carboxamide
 related_synonym: 10,11-Epoxycarbamazepine;   Carbamazepine 10,11-oxide;   Carbamazepine epoxide;   Formula=C15H12N2O2;   InChI=1S/C15H12N2O2/c16-15(18)17-11-7-3-1-5-9(11)13-14(19-13)10-6-2-4-8-12(10)17/h1-8,13-14H,(H2,16,18);   InChIKey=ZRWWEEVEIOGMMT-UHFFFAOYSA-N;   SMILES=NC(=O)N1c2ccccc2C2OC2c2ccccc12
 xref: Beilstein:1219988;   CAS:36507-30-9;   HMDB:HMDB0060658;   KEGG:C07496
 xref_mesh: MESH:C012227
 xref: PMID:22322005;   PMID:22443929;   PMID:24632353;   PMID:7233491;   Reaxys:1219988


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carbamazepine-10,11-epoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO carbamazepine epoxide binds to ALB protein CTD PMID:28562019 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects chemical synthesis
multiple interactions
ISO CYP2C8 protein affects the chemical synthesis of carbamazepine epoxide
Probenecid promotes the reaction [CYP2C8 protein affects the chemical synthesis of carbamazepine epoxide]
CTD PMID:15915352 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions ISO [EPHX1 gene SNP affects the metabolism of carbamazepine epoxide] which affects the chemical synthesis of 10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide; [EPHX1 protein results in increased metabolism of carbamazepine epoxide] which results in increased chemical synthesis of 10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide CTD PMID:15692831 NCBI chr13:99,271,390...99,300,580
Ensembl chr13:99,271,366...99,300,579
JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects binding ISO carbamazepine epoxide binds to GSTP1 protein CTD PMID:28562019 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO carbamazepine epoxide results in increased activity of NR1I2 protein CTD PMID:17112801 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        xenobiotic 18380
          carbamazepine 2027
            carbamazepine-10,11-epoxide 5
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18493
                              organic divalent group 18486
                                organodiyl group 18486
                                  carbonyl group 18389
                                    carbonyl compound 18389
                                      carboxylic acid 18060
                                        carboacyl group 17346
                                          univalent carboacyl group 17346
                                            carbamoyl group 17132
                                              carboxamide 17132
                                                monocarboxylic acid amide 14551
                                                  urea 4984
                                                    ureas 4982
                                                      carbamazepine 2027
                                                        carbamazepine-10,11-epoxide 5
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