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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:carbamazepine-10,11-epoxide
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Accession:CHEBI:3388 term browser browse the term
Definition:An epoxide and metabolite of carbamazepine.
Synonyms:exact_synonym: 1a,10b-dihydro-6H-dibenzo[b,f]oxireno[d]azepine-6-carboxamide
 related_synonym: 10,11-Epoxycarbamazepine;   Carbamazepine 10,11-oxide;   Carbamazepine epoxide;   Formula=C15H12N2O2;   InChI=1S/C15H12N2O2/c16-15(18)17-11-7-3-1-5-9(11)13-14(19-13)10-6-2-4-8-12(10)17/h1-8,13-14H,(H2,16,18);   InChIKey=ZRWWEEVEIOGMMT-UHFFFAOYSA-N;   SMILES=NC(=O)N1c2ccccc2C2OC2c2ccccc12
 xref: Beilstein:1219988;   CAS:36507-30-9;   HMDB:HMDB0060658;   KEGG:C07496
 xref_mesh: MESH:C012227
 xref: PMID:22322005;   PMID:22443929;   PMID:24632353;   PMID:7233491;   Reaxys:1219988


show annotations for term's descendants           Sort by:
carbamazepine-10,11-epoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin affects binding ISO carbamazepine epoxide binds to ALB protein CTD PMID:28562019 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects chemical synthesis
multiple interactions		 ISO CYP2C8 protein affects the chemical synthesis of carbamazepine epoxide
Probenecid promotes the reaction [CYP2C8 protein affects the chemical synthesis of carbamazepine epoxide]		 CTD PMID:15915352
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects chemical synthesis		 ISO [CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide; Felbamate affects the reaction [[CYP3A4 protein results in increased metabolism of Carbamazepine] which results in increased chemical synthesis of carbamazepine epoxide]; Probenecid promotes the reaction [CYP3A4 protein affects the chemical synthesis of carbamazepine epoxide] CTD PMID:12606595 PMID:15915352 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ephx1 epoxide hydrolase 1 multiple interactions ISO [EPHX1 gene SNP affects the metabolism of carbamazepine epoxide] which affects the chemical synthesis of 10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide; [EPHX1 protein results in increased metabolism of carbamazepine epoxide] which results in increased chemical synthesis of 10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide CTD PMID:15692831 NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235 		JBrowse link
G Gstp1 glutathione S-transferase pi 1 affects binding ISO carbamazepine epoxide binds to GSTP1 protein CTD PMID:28562019 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity ISO carbamazepine epoxide results in increased activity of NR1I2 protein CTD PMID:17112801 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19921
    role 19893
      biological role 19891
        xenobiotic 18774
          carbamazepine 2056
            carbamazepine-10,11-epoxide 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19921
    subatomic particle 19919
      composite particle 19919
        hadron 19919
          baryon 19919
            nucleon 19919
              atomic nucleus 19919
                atom 19919
                  main group element atom 19865
                    p-block element atom 19865
                      carbon group element atom 19804
                        carbon atom 19801
                          organic molecular entity 19801
                            heteroorganic entity 19558
                              organochalcogen compound 19317
                                organooxygen compound 19233
                                  carbon oxoacid 18695
                                    carboxylic acid 18692
                                      carboacyl group 17724
                                        univalent carboacyl group 17724
                                          carbamoyl group 17577
                                            carboxamide 17577
                                              monocarboxylic acid amide 15748
                                                urea 6225
                                                  ureas 6223
                                                    carbamazepine 2056
                                                      carbamazepine-10,11-epoxide 6
paths to the root