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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aromatic primary alcohol
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Accession:CHEBI:33857 term browser browse the term
Definition:Any primary alcohol in which the alcoholic hydroxy group is attached to a carbon which is itself bonded to an aromatic ring.
Synonyms:related_synonym: Formula=CH3OR;   SMILES=*C(O)([H])[H];   an aromatic primary alcohol;   aromatic primary alcohols
 alt_id: CHEBI:13823;   CHEBI:22628;   CHEBI:2838
 xref: KEGG:C03485



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1-hydroxymidazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases chemical synthesis
increases glucuronidation
multiple interactions
increases abundance
ISO CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam
CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam
[[3-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[5-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[6-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[6-methylflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[7-hydroxyflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[alpha-naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[artemetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[beta-Naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[chrysin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[flavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[galangin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[nobiletin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[sinensetin analog results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[sinensetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[tangeretin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam] which results in increased abundance of 1-hydroxymethylmidazolam glucuronide; [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased abundance of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [Ketoconazole results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam; [L 754394 results in decreased activity of CYP3A4 protein] which results in decreased chemical synthesis of 1-hydroxymethylmidazolam; acacetin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Apigenin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; CYP3A4 protein inhibits the reaction [Rifampin results in decreased chemical synthesis of 1-hydroxymethylmidazolam]; diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; flavanone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; flavone promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; galangin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased abundance of 1-hydroxymethylmidazolam]; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Luteolin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; NADP deficiency inhibits the reaction [erdafitinib inhibits the reaction [[CYP3A4 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]]; Rifampin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Rifampin promotes the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Troleandomycin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; Verapamil inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]
CTD PMID:10997946 PMID:12401345 PMID:12695342 PMID:18191104 PMID:20233841 More... NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases chemical synthesis
multiple interactions
ISO CYP3A5 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam
[CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; erdafitinib inhibits the reaction [[CYP3A5 protein results in increased hydroxylation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]
CTD PMID:18191104 PMID:26958860 PMID:34189909 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G Tspo translocator protein affects binding EXP 1-hydroxymethylmidazolam binds to TSPO protein; 1-hydroxymethylmidazolam metabolite binds to TSPO protein CTD PMID:7603229 NCBI chr 7:114,720,188...114,730,450
Ensembl chr 7:114,720,188...114,730,450
JBrowse link
1-hydroxymidazolam beta-D-glucuronide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions ISO [CYP3A4 protein results in increased glucuronidation of 1-hydroxymethylmidazolam] which results in increased abundance of 1-hydroxymethylmidazolam glucuronide CTD PMID:27485346 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
3-pyridinemethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1b8 aldo-keto reductase family 1, member B8 multiple interactions EXP [AKR1B8 protein co-treated with NADP] affects the oxidation of Nicotinyl Alcohol CTD PMID:18845131 NCBI chr 4:62,997,241...63,009,815 JBrowse link
5-(hydroxymethyl)cytosine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase decreases methylation ISO 5-hydroxymethylcytosine results in decreased methylation of ATM gene CTD PMID:30990028 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Cmahp cytidine monophospho-N-acetylneuraminic acid hydroxylase, pseudogene multiple interactions ISO [bisphenol A results in decreased methylation of CMAH intron] which results in decreased abundance of 5-hydroxymethylcytosine CTD PMID:30044229 NCBI chr17:40,557,161...40,642,350
Ensembl chr17:40,583,667...40,642,275
JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions ISO DNMT1 protein promotes the reaction [bis(4-hydroxyphenyl)sulfone results in decreased abundance of 5-hydroxymethylcytosine]; DNMT1 protein promotes the reaction [bisphenol A results in decreased abundance of 5-hydroxymethylcytosine] CTD PMID:32105160 NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
JBrowse link
G Dnmt3a DNA methyltransferase 3 alpha multiple interactions ISO DNMT3A protein promotes the reaction [bis(4-hydroxyphenyl)sulfone results in decreased abundance of 5-hydroxymethylcytosine]; DNMT3A protein promotes the reaction [bisphenol A results in decreased abundance of 5-hydroxymethylcytosine] CTD PMID:32105160 NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
JBrowse link
G Esr1 estrogen receptor 1 decreases abundance
multiple interactions
ISO ESR1 protein results in decreased abundance of 5-hydroxymethylcytosine
ESR1 protein promotes the reaction [bis(4-hydroxyphenyl)sulfone results in decreased abundance of 5-hydroxymethylcytosine]; ESR1 protein promotes the reaction [bisphenol A results in decreased abundance of 5-hydroxymethylcytosine]
CTD PMID:32105160 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions ISO [Chloranil results in increased abundance of 5-hydroxymethylcytosine] which results in increased expression of FTL mRNA CTD PMID:24214992 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G Gnas GNAS complex locus multiple interactions ISO [bisphenol A results in increased methylation of GNAS intron] which results in increased abundance of 5-hydroxymethylcytosine CTD PMID:30044229 NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262
JBrowse link
G Grb10 growth factor receptor bound protein 10 multiple interactions ISO [bisphenol A results in increased methylation of GRB10 intron] which results in increased abundance of 5-hydroxymethylcytosine CTD PMID:30044229 NCBI chr14:86,495,054...86,602,815
Ensembl chr14:86,495,054...86,602,806
JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases abundance ISO IDH2 protein mutant form results in decreased abundance of 5-hydroxymethylcytosine CTD PMID:27469509 NCBI chr 1:134,038,644...134,057,969
Ensembl chr 1:134,029,772...134,058,025
JBrowse link
G Kcnq1 potassium voltage-gated channel subfamily Q member 1 multiple interactions ISO [bisphenol A results in decreased methylation of KCNQ1 intron] which results in decreased abundance of 5-hydroxymethylcytosine CTD PMID:30044229 NCBI chr 1:198,291,711...198,624,683
Ensembl chr 1:198,291,766...198,624,669
JBrowse link
G Klf14 Kruppel-like factor 14 multiple interactions ISO [bisphenol A results in decreased methylation of KLF14 exon] which results in decreased abundance of 5-hydroxymethylcytosine CTD PMID:30044229 NCBI chr 4:59,554,011...59,556,933
Ensembl chr 4:59,554,011...59,556,933
JBrowse link
G Pde10a phosphodiesterase 10A multiple interactions ISO [bisphenol A results in increased methylation of PDE10A intron] which results in increased abundance of 5-hydroxymethylcytosine CTD PMID:30044229 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563
JBrowse link
G Pde4d phosphodiesterase 4D multiple interactions ISO [bisphenol A results in increased methylation of PDE4D exon] which results in increased abundance of 5-hydroxymethylcytosine CTD PMID:30044229 NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884
JBrowse link
G Plagl1 PLAG1 like zinc finger 1 multiple interactions ISO [bisphenol A results in increased methylation of PLAGL1 exon] which results in increased abundance of 5-hydroxymethylcytosine CTD PMID:30044229 NCBI chr 1:7,477,295...7,517,229
Ensembl chr 1:7,477,177...7,517,228
JBrowse link
G Ppp1r9a protein phosphatase 1, regulatory subunit 9A multiple interactions ISO [bisphenol A results in decreased methylation of PPP1R9A intron] which results in decreased abundance of 5-hydroxymethylcytosine CTD PMID:30044229 NCBI chr 4:32,970,501...33,292,360
Ensembl chr 4:33,024,450...33,286,907
JBrowse link
G Tet1 tet methylcytosine dioxygenase 1 multiple interactions ISO TET1 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased chemical synthesis of 5-hydroxymethylcytosine]; TET1 protein affects the reaction [Chloranil results in increased chemical synthesis of 5-hydroxymethylcytosine] CTD PMID:24214992 NCBI chr20:25,761,042...25,840,926
Ensembl chr20:25,768,120...25,833,052
JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 multiple interactions
increases abundance
ISO TET2 protein affects the reaction [2,3,5,6-tetrachlorohydroquinone results in increased chemical synthesis of 5-hydroxymethylcytosine]; TET2 protein affects the reaction [Chloranil results in increased chemical synthesis of 5-hydroxymethylcytosine]
TET2 protein results in increased abundance of 5-hydroxymethylcytosine
bis(4-hydroxyphenyl)sulfone promotes the reaction [TET2 protein results in increased abundance of 5-hydroxymethylcytosine]; bisphenol A promotes the reaction [TET2 protein results in increased abundance of 5-hydroxymethylcytosine]; TET2 protein inhibits the reaction [bis(4-hydroxyphenyl)sulfone results in decreased abundance of 5-hydroxymethylcytosine]; TET2 protein inhibits the reaction [bisphenol A results in decreased abundance of 5-hydroxymethylcytosine]
CTD PMID:24214992 PMID:32105160 NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534
JBrowse link
G Ubc ubiquitin C multiple interactions ISO [Chloranil results in increased abundance of 5-hydroxymethylcytosine] which results in increased expression of UBC mRNA CTD PMID:24214992 NCBI chr12:31,238,889...31,243,924
Ensembl chr12:31,239,152...31,243,925
JBrowse link
Aloe emodin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in decreased expression of ADIPOQ mRNA] CTD PMID:22645054 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Atf3 activating transcription factor 3 increases expression ISO aloe emodin results in increased expression of ATF3 mRNA CTD PMID:22210228 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO aloe emodin results in increased expression of BAX protein CTD PMID:19928967 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO aloe emodin results in decreased expression of BCL2 mRNA; aloe emodin results in decreased expression of BCL2 protein CTD PMID:19928967 PMID:22210228 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
increases expression
ISO aloe emodin results in increased activity of CASP3 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP3; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP3 protein modified form]
aloe emodin results in increased cleavage of CASP3 protein
CTD PMID:19928967 PMID:22210228 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity
multiple interactions
increases expression
ISO aloe emodin results in increased activity of CASP8 protein
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP8; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP8 protein modified form]
CTD PMID:19928967 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity
increases expression
multiple interactions
ISO aloe emodin results in increased activity of CASP9 protein
aloe emodin results in increased expression of CASP9 protein modified form
[Fluorouracil co-treated with aloe emodin] affects the expression of CASP9; Fluorouracil promotes the reaction [aloe emodin results in increased expression of CASP9 protein modified form]
CTD PMID:19928967 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cycs cytochrome c, somatic increases expression ISO aloe emodin results in increased expression of CYCS protein CTD PMID:19928967 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO aloe emodin results in decreased activity of CYP1A1 protein CTD PMID:27633141 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO aloe emodin results in decreased activity of CYP1A2 protein CTD PMID:27633141 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO aloe emodin results in decreased activity of CYP1B1 protein CTD PMID:27633141 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases chemical synthesis
ISO [CYP2B6 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CYP2B6 protein results in increased chemical synthesis of aloe emodin
CTD PMID:29698620 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases chemical synthesis
multiple interactions
ISO CYP3A4 protein results in increased chemical synthesis of aloe emodin
[CYP3A4 protein results in increased metabolism of chrysophanic acid] which results in increased chemical synthesis of aloe emodin
CTD PMID:29698620 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO aloe emodin results in increased expression of DDIT3 mRNA; aloe emodin results in increased expression of DDIT3 protein CTD PMID:22210228 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation ISO aloe emodin results in increased phosphorylation of EIF2S1 protein CTD PMID:22210228 NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of FABP4 mRNA] CTD PMID:22645054 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fadd Fas associated via death domain multiple interactions ISO aloe emodin results in increased expression of and affects the localization of FADD protein CTD PMID:19928967 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO aloe emodin results in increased expression of FAS protein CTD PMID:19928967 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand increases expression ISO aloe emodin results in increased expression of FASLG protein CTD PMID:19928967 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO aloe emodin results in increased expression of HSPA5 mRNA; aloe emodin results in increased expression of HSPA5 protein CTD PMID:22210228 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Lpl lipoprotein lipase multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of LPL mRNA] CTD PMID:22645054 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Nat1 N-acetyltransferase 1 multiple interactions
decreases expression
ISO aloe emodin results in decreased expression of and results in decreased activity of NAT1 protein
aloe emodin results in decreased expression of NAT1 mRNA
CTD PMID:16314733 NCBI chr16:22,218,217...22,238,516 JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] CTD PMID:19352036 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of PPARG mRNA] CTD PMID:22645054 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO aloe emodin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA] CTD PMID:19352036 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Retn resistin multiple interactions ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of RETN mRNA] CTD PMID:22645054 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 decreases activity ISO aloe emodin results in decreased activity of SULT1A1 protein CTD PMID:27633141 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562
JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 decreases activity ISO aloe emodin results in decreased activity of SULT1E1 protein CTD PMID:27633141 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275
JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression
ISO aloe emodin inhibits the reaction [1-Methyl-3-isobutylxanthine results in increased expression of TNF mRNA]
aloe emodin results in increased expression of TNF protein
CTD PMID:19928967 PMID:22645054 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A increases expression ISO aloe emodin results in increased expression of TNFRSF1A protein CTD PMID:19928967 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B increases expression ISO aloe emodin results in increased expression of TNFRSF1B protein CTD PMID:19928967 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Tp53 tumor protein p53 increases expression ISO aloe emodin results in increased expression of TP53 protein CTD PMID:19928967 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tradd TNFRSF1A-associated via death domain multiple interactions ISO aloe emodin results in increased expression of and affects the localization of TRADD protein CTD PMID:19928967 NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of aloe emodin CTD PMID:24854283 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Xbp1 X-box binding protein 1 increases splicing ISO aloe emodin results in increased splicing of XBP1 mRNA CTD PMID:22210228 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link
salicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO ALB protein binds to and affects the transport of salicin CTD PMID:8831264 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Tas2r118 taste receptor, type 2, member 118 multiple interactions
increases activity
ISO 4-((diethylamino)sulfonyl)benzoic acid inhibits the reaction [salicin results in increased activity of TAS2R16 protein]; Probenecid inhibits the reaction [salicin results in increased activity of TAS2R16 protein] CTD PMID:21629661 NCBI chr 4:52,449,208...52,450,107
Ensembl chr 4:52,449,208...52,450,107
JBrowse link
salicyl alcohol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO ALB protein binds to and affects the transport of salicyl alcohol CTD PMID:8831264 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO [2-(2-cresyl)-4H-1-3-2-benzodioxaphosphorin-2-oxide binds to and results in decreased activity of BCHE protein] which results in increased abundance of salicyl alcohol CTD PMID:22898212 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP salicyl alcohol inhibits the reaction [2,2'-azobis(2-amidinopropane) results in decreased activity of SOD2 protein] CTD PMID:19665455 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19795
    chemical entity 19795
      molecular entity 19794
        polyatomic entity 19716
          heteroatomic molecular entity 19657
            hydroxides 19152
              organic hydroxy compound 18652
                alcohol 15081
                  primary alcohol 14000
                    aromatic primary alcohol 60
                      (7R,8R)-AGI-B4 0
                      1',4-dihydroxymidazolam 0
                      1-hydroxymidazolam + 3
                      12-hydroxynevirapine 0
                      2-hydroxy-4-hydroxymethylbenzylidenepyruvic acid 0
                      3-pyridinemethanol 1
                      4-(hydroxymethyl)-2-propylfuran-3-carboxylic acid 0
                      4-(trifluoromethyl)benzyl alcohol 0
                      4-acetoxybenzyl alcohol 0
                      4-amino-5-hydroxymethyl-2-methylpyrimidine 0
                      4-aminopyridine-3-methanol 0
                      4-cyanobenzyl alcohol 0
                      4-hydroxymethylsalicylaldehyde 0
                      5-(hydroxymethyl)cytosine + 18
                      5-hydroxymethyl-2-furoic acid 0
                      Aloe emodin 35
                      GSK1016790A 0
                      N-substituted pyrraline + 0
                      \{2-[(isopropylamino)methyl]-7-nitro-1,2,3,4-tetrahydroquinolin-6-yl\}methanol + 0
                      aspergillusone B 0
                      dihydropyriculariol 0
                      gentisyl alcohol 0
                      hydroxy torasemide 0
                      lificiguat 0
                      pyrraline + 0
                      salicin + 2
                      salicyl alcohol + 4
                      tremuloidin 0
                      trichoxide 0
                      triptohypol A 0
                      variecoxanthone C 0
                      virensol A 0
                      virensol B 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19795
    subatomic particle 19794
      composite particle 19794
        hadron 19794
          baryon 19794
            nucleon 19794
              atomic nucleus 19794
                atom 19794
                  main group element atom 19693
                    p-block element atom 19693
                      chalcogen 19445
                        oxygen atom 19418
                          oxygen molecular entity 19418
                            hydroxides 19152
                              organic hydroxy compound 18652
                                alcohol 15081
                                  primary alcohol 14000
                                    aromatic primary alcohol 60
                                      (7R,8R)-AGI-B4 0
                                      1',4-dihydroxymidazolam 0
                                      1-hydroxymidazolam + 3
                                      12-hydroxynevirapine 0
                                      2-hydroxy-4-hydroxymethylbenzylidenepyruvic acid 0
                                      3-pyridinemethanol 1
                                      4-(hydroxymethyl)-2-propylfuran-3-carboxylic acid 0
                                      4-(trifluoromethyl)benzyl alcohol 0
                                      4-acetoxybenzyl alcohol 0
                                      4-amino-5-hydroxymethyl-2-methylpyrimidine 0
                                      4-aminopyridine-3-methanol 0
                                      4-cyanobenzyl alcohol 0
                                      4-hydroxymethylsalicylaldehyde 0
                                      5-(hydroxymethyl)cytosine + 18
                                      5-hydroxymethyl-2-furoic acid 0
                                      Aloe emodin 35
                                      GSK1016790A 0
                                      N-substituted pyrraline + 0
                                      \{2-[(isopropylamino)methyl]-7-nitro-1,2,3,4-tetrahydroquinolin-6-yl\}methanol + 0
                                      aspergillusone B 0
                                      dihydropyriculariol 0
                                      gentisyl alcohol 0
                                      hydroxy torasemide 0
                                      lificiguat 0
                                      pyrraline + 0
                                      salicin + 2
                                      salicyl alcohol + 4
                                      tremuloidin 0
                                      trichoxide 0
                                      triptohypol A 0
                                      variecoxanthone C 0
                                      virensol A 0
                                      virensol B 0
paths to the root