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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:arenecarbaldehyde
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Accession:CHEBI:33855 term browser browse the term
Definition:Any aldehyde in which the carbonyl group is attached to an aromatic moiety.
Synonyms:related_synonym: Aromatic aldehyde;   Formula=CHOR;   SMILES=*C(=O)[H];   an aromatic aldehyde;   arenecarbaldehydes;   aryl aldehyde;   aryl aldehydes
 alt_id: CHEBI:13819;   CHEBI:22621;   CHEBI:2832;   CHEBI:87908
 xref: KEGG:C00193;   MetaCyc:Aryl-Aldehyde


show annotations for term's descendants           Sort by:
1-naphthaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO 1-naphthaldehyde inhibits the reaction [Metribolone binds to AR protein] CTD PMID:3695475 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
2,5-dihydroxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2, mitochondrial increases metabolic processing ISO ALDH2 protein results in increased metabolism of 2,5-dihydroxybenzaldehyde CTD PMID:11744614 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
2-nitrobenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr7a5 aldo-keto reductase family 7, member A5 increases reduction
affects reduction		 ISO
EXP		 AKR7A2 protein results in increased reduction of 2-nitrobenzaldehyde
2-nitrobenzaldehyde affects the reduction of AKR7A5 protein		 CTD PMID:10510318 PMID:12604212 NCBI chr 4:139,038,005...139,046,097
Ensembl chr 4:139,038,055...139,045,737 		JBrowse link
3,4-dihydroxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of ACHE protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of ACHE protein] CTD PMID:29665407 PMID:29732668 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Acta2 actin alpha 2, smooth muscle, aorta multiple interactions ISO protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of ACTA2 protein] CTD PMID:25582705 NCBI chr19:34,217,736...34,232,985
Ensembl chr19:34,218,490...34,232,990 		JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions ISO protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of AGER protein]
protocatechualdehyde inhibits the reaction [Bleomycin results in decreased expression of AGER protein]		 CTD PMID:17597607 PMID:25582705 NCBI chr17:34,816,545...34,819,911
Ensembl chr17:34,816,836...34,819,910 		JBrowse link
G Cat catalase multiple interactions
increases activity		 ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of CAT protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of CAT protein]
protocatechualdehyde results in increased activity of CAT protein		 CTD PMID:29665407 PMID:29732668 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] CTD PMID:25582705 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of FGF2 protein]
protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of FGF2 protein]		 CTD PMID:25582705 NCBI chr 3:37,402,616...37,464,255
Ensembl chr 3:37,402,495...37,464,257 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked multiple interactions ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of G6PD protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of G6PD protein] CTD PMID:29665407 PMID:29732668 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO protocatechualdehyde inhibits the reaction [sodium arsenite results in increased activity of GLO1 protein] CTD PMID:29732668 NCBI chr17:30,811,835...30,831,633
Ensembl chr17:30,803,910...30,845,845 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in decreased activity of GSR protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] CTD PMID:29665407 PMID:29732668 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO protocatechualdehyde inhibits the reaction [Bleomycin results in increased expression of HMGB1 protein]
protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of HMGB1 protein]		 CTD PMID:25582705 NCBI chr 5:148,983,512...148,989,867
Ensembl chr 5:148,983,512...149,121,299 		JBrowse link
G S100b S100 protein, beta polypeptide, neural multiple interactions ISO protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of AGER protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD2 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:17597607 NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD2 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD2 protein] CTD PMID:17597607 NCBI chr18:76,369,898...76,444,819
Ensembl chr18:76,374,651...76,444,034 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO protocatechualdehyde inhibits the reaction [Glucose results in increased phosphorylation of and affects the localization of SMAD3 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased phosphorylation of and affects the localization of SMAD3 protein] CTD PMID:17597607 NCBI chr 9:63,554,048...63,665,276
Ensembl chr 9:63,554,049...63,665,276 		JBrowse link
G Sod1 superoxide dismutase 1, soluble multiple interactions ISO protocatechualdehyde inhibits the reaction [Potassium Dichromate results in increased activity of SOD1 protein]; protocatechualdehyde inhibits the reaction [sodium arsenite results in decreased activity of SOD1 protein] CTD PMID:29665407 PMID:29732668 NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO protocatechualdehyde inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [Glucose results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 mRNA]; protocatechualdehyde inhibits the reaction [S100B protein results in increased expression of TGFB1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of AGER protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of FGF2 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of HMGB1 protein]; protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:17597607 PMID:25582705 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Vim vimentin multiple interactions ISO protocatechualdehyde inhibits the reaction [TGFB1 protein results in increased expression of VIM protein] CTD PMID:25582705 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637 		JBrowse link
3,5-di-tert-Butyl-4-hydroxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of AR protein CTD PMID:27633901 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of ESR1 protein CTD PMID:27633901 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of NR3C1 protein CTD PMID:27633901 NCBI chr18:39,543,598...39,652,485
Ensembl chr18:39,543,598...39,652,474 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of PPARG protein CTD PMID:27633901 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO 3,5-di-tert-butyl-4-hydroxybenzaldehyde binds to and results in decreased activity of THRB protein CTD PMID:27633901 NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435 		JBrowse link
3-hydroxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh2 aldehyde dehydrogenase 2, mitochondrial increases metabolic processing ISO ALDH2 protein results in increased metabolism of 3-hydroxybenzaldehyde CTD PMID:11744614 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
4-(diethylamino)benzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 decreases activity
multiple interactions
increases oxidation		 EXP
ISO		 4-(diethylamino)benzaldehyde results in decreased activity of ALDH1A1 protein
4-(diethylamino)benzaldehyde inhibits the reaction [ALDH1A1 protein results in decreased susceptibility to mafosfamide]
ALDH1A1 protein results in increased oxidation of 4-(diethylamino)benzaldehyde		 CTD PMID:8662658 PMID:16316642 PMID:25512087 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829 		JBrowse link
G Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 multiple interactions ISO 4-(diethylamino)benzaldehyde binds to and results in decreased activity of ALDH1A2 protein CTD PMID:25512087 NCBI chr 9:71,123,071...71,203,525
Ensembl chr 9:71,123,071...71,203,525 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial multiple interactions ISO 4-(diethylamino)benzaldehyde binds to and results in decreased activity of ALDH2 protein CTD PMID:25512087 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase family 3, subfamily A1 increases oxidation ISO ALDH3A1 protein results in increased oxidation of 4-(diethylamino)benzaldehyde CTD PMID:25512087 NCBI chr11:61,099,336...61,109,244
Ensembl chr11:61,098,363...61,109,247 		JBrowse link
4-formylbenzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1, member A1 increases reduction ISO AKR1A1 protein results in increased reduction of 4-carboxybenzaladehyde CTD PMID:10510318 NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877 		JBrowse link
4-nitrobenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1, member A1 increases reduction ISO AKR1A1 protein results in increased reduction of 4-nitrobenzaldehyde CTD PMID:10510318 NCBI chr 4:116,493,707...116,508,871
Ensembl chr 4:116,493,707...116,508,877 		JBrowse link
G Akr1b1 aldo-keto reductase family 1 member B increases reduction ISO AKR1B1 protein results in increased reduction of 4-nitrobenzaldehyde CTD PMID:10510318 NCBI chr 6:34,280,865...34,294,424
Ensembl chr 6:34,279,369...34,294,413 		JBrowse link
G Akr1b7 aldo-keto reductase family 1, member B7 increases metabolic processing ISO AKR1B15 protein results in increased metabolism of 4-nitrobenzaldehyde CTD PMID:21276782 NCBI chr 6:34,389,297...34,400,072
Ensembl chr 6:34,389,269...34,400,077 		JBrowse link
G Akr7a5 aldo-keto reductase family 7, member A5 multiple interactions
affects reduction		 EXP Ethacrynic Acid inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein]; Indomethacin inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein]; Quercetin inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein]; Valproic Acid inhibits the reaction [4-nitrobenzaldehyde affects the reduction of AKR7A5 protein] CTD PMID:12604212 NCBI chr 4:139,038,005...139,046,097
Ensembl chr 4:139,038,055...139,045,737 		JBrowse link
G Dhrs7 dehydrogenase/reductase 7 increases reduction ISO DHRS7 protein results in increased reduction of 4-nitrobenzaldehyde CTD PMID:24246760 NCBI chr12:72,697,127...72,711,678
Ensembl chr12:72,697,127...72,711,683 		JBrowse link
G Dyrk2 dual-specificity tyrosine phosphorylation regulated kinase 2 multiple interactions ISO [Curcumin binds to 4-nitrobenzaldehyde] which results in decreased activity of DYRK2 protein CTD PMID:33617879 NCBI chr10:118,691,507...118,725,144
Ensembl chr10:118,691,508...118,706,114 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions EXP NFE2L2 protein promotes the reaction [sulforaphane results in decreased susceptibility to 4-nitrobenzaldehyde] CTD PMID:20932822 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
5-hydroxymethylfurfural term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nphs1 nephrosis 1, nephrin decreases expression ISO 5-hydroxymethylfurfural co-treated with 3,4-dideoxyglucosone co-treated with Glyoxal co-treated with Methylglyoxal cotreated with 3-deoxyglucosone co-treated with Formaldehyde co-treated with acetaldehyde decreases expression of Nphs1 protein in kidneys RGD PMID:18346151 RGD:38599007 NCBI chr 7:30,157,259...30,188,048
Ensembl chr 7:30,157,740...30,186,648 		JBrowse link
G Sult1a1 sulfotransferase family 1A, phenol-preferring, member 1 multiple interactions
increases activity		 ISO [SULT1A1 protein co-treated with SULT1A2 protein] results in increased susceptibility to 5-hydroxymethylfurfural
SULT1A2 protein results in increased activity of 5-hydroxymethylfurfural		 CTD PMID:22006426 NCBI chr 7:126,272,042...126,289,615
Ensembl chr 7:126,272,037...126,275,604 		JBrowse link
G Sult1d1 sulfotransferase family 1D, member 1 increases metabolic processing EXP SULT1D1 protein results in increased metabolism of 5-hydroxymethylfurfural CTD PMID:25370010 NCBI chr 5:87,702,509...87,716,865
Ensembl chr 5:87,702,504...87,716,886 		JBrowse link
G Sult5a1 sulfotransferase family 5A, member 1 increases metabolic processing EXP SULT1A1 protein results in increased metabolism of 5-hydroxymethylfurfural CTD PMID:25370010 NCBI chr 8:123,869,582...123,885,170
Ensembl chr 8:123,866,931...123,885,054 		JBrowse link
benzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a1 aldehyde dehydrogenase family 1, subfamily A1 increases oxidation
increases metabolic processing		 ISO
EXP		 ALDH1A1 protein results in increased oxidation of benzaldehyde
ALDH1A1 protein results in increased metabolism of benzaldehyde		 CTD PMID:10998257 PMID:21256123 NCBI chr19:20,469,947...20,620,827
Ensembl chr19:20,470,079...20,620,829 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial increases metabolic processing
multiple interactions		 ISO ALDH2 protein results in increased metabolism of benzaldehyde
benzaldehyde inhibits the reaction [4-dimethylaminocinnamaldehyde binds to ALDH2 protein]		 CTD PMID:10609638 PMID:11744614 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
G Aldh3a1 aldehyde dehydrogenase family 3, subfamily A1 multiple interactions
increases oxidation
increases metabolic processing		 ISO
EXP		 [ALDH3A1 protein co-treated with NAD] results in increased oxidation of benzaldehyde; [ALDH3A1 protein co-treated with NADP] results in increased oxidation of benzaldehyde; Cimetidine inhibits the reaction [ALDH3A1 protein results in increased oxidation of benzaldehyde]
ALDH3A1 protein results in increased metabolism of benzaldehyde		 CTD PMID:10856427 PMID:21256123 PMID:21349255 PMID:23220590 PMID:25512087 NCBI chr11:61,099,336...61,109,244
Ensembl chr11:61,098,363...61,109,247 		JBrowse link
G Aldh3b1 aldehyde dehydrogenase 3 family, member B1 affects binding ISO benzaldehyde binds to ALDH3B1 protein CTD PMID:20699116 NCBI chr19:3,963,491...3,980,898
Ensembl chr19:3,963,491...3,979,808 		JBrowse link
G Ar androgen receptor multiple interactions ISO benzaldehyde inhibits the reaction [Metribolone binds to AR protein] CTD PMID:3695475 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 multiple interactions
decreases activity
increases chemical synthesis		 ISO [[benzaldehyde results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin; [benzaldehyde results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin
CYP2A6 protein results in increased chemical synthesis of benzaldehyde		 CTD PMID:10616189 PMID:32496054 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973 		JBrowse link
G Or8a1b olfactory receptor family 8 subfamily A member 1B multiple interactions EXP benzaldehyde binds to and results in increased activity of OR8A1 protein CTD PMID:11943806 NCBI chr 9:37,622,644...37,623,576
Ensembl chr 9:37,620,260...37,627,546 		JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 increases activity
multiple interactions		 EXP benzaldehyde results in increased activity of SLC2A1 protein
[benzaldehyde co-treated with Glucose deficiency] results in decreased activity of SLC2A1 protein		 CTD PMID:20955755 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180 		JBrowse link
benzaldehydes term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aldh1a2 aldehyde dehydrogenase family 1, subfamily A2 decreases activity ISO Benzaldehydes results in decreased activity of ALDH1A2 protein CTD PMID:22079344 NCBI chr 9:71,123,071...71,203,525
Ensembl chr 9:71,123,071...71,203,525 		JBrowse link
G Aldh2 aldehyde dehydrogenase 2, mitochondrial decreases activity ISO Benzaldehydes results in decreased activity of ALDH2 protein CTD PMID:22079344 NCBI chr 5:121,704,090...121,731,887
Ensembl chr 5:121,704,090...121,731,887 		JBrowse link
ethyl vanillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 multiple interactions
decreases activity		 ISO [[ethyl vanillin results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin; [ethyl vanillin results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin CTD PMID:32496054 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973 		JBrowse link
G Or5d18 olfactory receptor family 5 subfamily D member 18 multiple interactions EXP [ethyl vanillin binds to and results in increased activity of OR5D18 protein] which results in increased transport of Calcium; ethyl vanillin binds to and results in increased activity of OR5D18 protein CTD PMID:15716417 NCBI chr 2:87,864,540...87,865,481
Ensembl chr 2:87,862,632...87,868,043 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity EXP ethyl vanillin results in increased activity of TRPV3 protein CTD PMID:16617338 NCBI chr11:73,158,315...73,191,194
Ensembl chr11:73,158,214...73,191,189 		JBrowse link
m-tolualdehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO 3-methylbenzaldehyde results in decreased activity of CYP2E1 protein CTD PMID:12791539 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Cyp4b1 cytochrome P450, family 4, subfamily b, polypeptide 1 affects activity ISO 3-methylbenzaldehyde affects the activity of CYP4B1 protein CTD PMID:12791539 NCBI chr 4:115,481,895...115,504,918
Ensembl chr 4:115,481,922...115,504,920 		JBrowse link
oncrasin-1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kras Kirsten rat sarcoma viral oncogene homolog increases response to substance ISO KRAS protein mutant form results in increased susceptibility to oncrasin-1 CTD PMID:21443218 NCBI chr 6:145,162,425...145,197,631
Ensembl chr 6:145,162,425...145,195,965 		JBrowse link
ortho-vanillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 increases glucuronidation ISO UGT1A10 protein results in increased glucuronidation of 2-vanillin CTD PMID:15117964 NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of 2-vanillin CTD PMID:15117964 NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719 		JBrowse link
p-methoxybenzaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Trpa1 transient receptor potential cation channel, subfamily A, member 1 increases activity ISO 4-anisaldehyde results in increased activity of TRPA1 protein CTD PMID:21591660 NCBI chr 1:14,942,868...14,989,086
Ensembl chr 1:14,942,872...14,989,086 		JBrowse link
p-tolualdehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl-hydrocarbon receptor multiple interactions EXP 4-methylbenzaldehyde binds to and results in decreased activity of AHR protein CTD PMID:27633901 NCBI chr12:35,547,978...35,584,988
Ensembl chr12:35,547,973...35,585,037 		JBrowse link
G Ar androgen receptor multiple interactions ISO 4-methylbenzaldehyde binds to and results in decreased activity of AR protein CTD PMID:27633901 NCBI chr  X:97,192,363...97,366,824
Ensembl chr  X:97,192,375...97,366,821 		JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO 4-methylbenzaldehyde binds to and results in decreased activity of ESR2 protein CTD PMID:27633901 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IL1B protein] CTD PMID:27569861 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] CTD PMID:27569861 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Mapk1 mitogen-activated protein kinase 1 multiple interactions EXP 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:27569861 NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions EXP 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:27569861 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions EXP 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein] CTD PMID:27569861 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha multiple interactions EXP 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:27569861 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions EXP 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:27569861 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Pgr progesterone receptor multiple interactions ISO 4-methylbenzaldehyde binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr 9:8,890,017...8,968,612
Ensembl chr 9:8,899,834...8,968,612 		JBrowse link
G Pparg peroxisome proliferator activated receptor gamma multiple interactions ISO 4-methylbenzaldehyde binds to and results in decreased activity of PPARG protein CTD PMID:27633901 NCBI chr 6:115,337,828...115,467,365
Ensembl chr 6:115,337,912...115,467,360 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:27569861 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:27569861 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 4-methylbenzaldehyde analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:27569861 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
phthalaldehyde term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aicda activation-induced cytidine deaminase affects expression EXP o-Phthalaldehyde affects the expression of AICDA mRNA CTD PMID:22302311 NCBI chr 6:122,530,768...122,541,139
Ensembl chr 6:122,530,760...122,541,139 		JBrowse link
G Akr1c18 aldo-keto reductase family 1, member C18 affects expression EXP o-Phthalaldehyde affects the expression of AKR1C18 mRNA CTD PMID:22302311 NCBI chr13:4,182,614...4,200,645
Ensembl chr13:4,182,614...4,200,653 		JBrowse link
G Ccl6 C-C motif chemokine ligand 6 affects expression EXP o-Phthalaldehyde affects the expression of CCL6 mRNA CTD PMID:22302311 NCBI chr11:83,478,712...83,483,913
Ensembl chr11:83,478,708...83,483,913 		JBrowse link
G Ccna2 cyclin A2 affects expression EXP o-Phthalaldehyde affects the expression of CCNA2 mRNA CTD PMID:22302311 NCBI chr 3:36,619,014...36,627,187
Ensembl chr 3:36,619,014...36,626,299 		JBrowse link
G Ccnb1 cyclin B1 affects expression EXP o-Phthalaldehyde affects the expression of CCNB1 mRNA CTD PMID:22302311 NCBI chr13:100,915,247...100,922,994
Ensembl chr13:100,915,158...100,923,078 		JBrowse link
G Ccne2 cyclin E2 affects expression EXP o-Phthalaldehyde affects the expression of CCNE2 mRNA CTD PMID:22302311 NCBI chr 4:11,190,489...11,204,781
Ensembl chr 4:11,191,351...11,204,779 		JBrowse link
G Ccr4 C-C motif chemokine receptor 4 affects expression EXP o-Phthalaldehyde affects the expression of CCR4 mRNA CTD PMID:22302311 NCBI chr 9:114,319,384...114,334,544
Ensembl chr 9:114,319,384...114,333,984 		JBrowse link
G Cd207 CD207 antigen affects expression EXP o-Phthalaldehyde affects the expression of CD207 mRNA CTD PMID:22302311 NCBI chr 6:83,648,189...83,654,839
Ensembl chr 6:83,648,197...83,654,839 		JBrowse link
G Cd5l CD5 antigen-like affects expression EXP o-Phthalaldehyde affects the expression of CD5L mRNA CTD PMID:22302311 NCBI chr 3:87,265,188...87,278,381
Ensembl chr 3:87,265,188...87,278,380 		JBrowse link
G Cd83 CD83 antigen affects expression EXP o-Phthalaldehyde affects the expression of CD83 mRNA CTD PMID:22302311 NCBI chr13:43,938,661...43,956,608
Ensembl chr13:43,938,251...43,956,608 		JBrowse link
G Cdc20 cell division cycle 20 affects expression EXP o-Phthalaldehyde affects the expression of CDC20 mRNA CTD PMID:22302311 NCBI chr 4:118,290,098...118,294,540
Ensembl chr 4:118,290,098...118,294,549 		JBrowse link
G Cdc25c cell division cycle 25C affects expression EXP o-Phthalaldehyde affects the expression of CDC25C mRNA CTD PMID:22302311 NCBI chr18:34,866,046...34,884,644
Ensembl chr18:34,866,046...34,884,586 		JBrowse link
G Cdk1 cyclin dependent kinase 1 affects expression EXP o-Phthalaldehyde affects the expression of CDK1 mRNA CTD PMID:22302311 NCBI chr10:69,170,976...69,188,742
Ensembl chr10:69,170,976...69,188,768 		JBrowse link
G Clec7a C-type lectin domain family 7, member a affects expression EXP o-Phthalaldehyde affects the expression of CLEC7A mRNA CTD PMID:22302311 NCBI chr 6:129,438,554...129,449,748
Ensembl chr 6:129,438,554...129,449,742 		JBrowse link
G Col8a1 collagen, type VIII, alpha 1 affects expression EXP o-Phthalaldehyde affects the expression of COL8A1 mRNA CTD PMID:22302311 NCBI chr16:57,444,619...57,575,100
Ensembl chr16:57,444,621...57,575,100 		JBrowse link
G Cphx1 cytoplasmic polyadenylated homeobox 1 affects expression EXP o-Phthalaldehyde affects the expression of CPHX1 mRNA CTD PMID:22302311 NCBI chr14:25,941,983...25,956,798
Ensembl chr14:25,938,728...25,956,780 		JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 affects expression EXP o-Phthalaldehyde affects the expression of CTLA4 mRNA CTD PMID:22302311 NCBI chr 1:60,948,184...60,954,991
Ensembl chr 1:60,926,159...60,954,991 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases expression EXP o-Phthalaldehyde results in decreased expression of CYP1A1 mRNA CTD PMID:20112102 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases expression EXP o-Phthalaldehyde results in decreased expression of CYP2E1 mRNA CTD PMID:20112102 NCBI chr 7:140,343,732...140,354,903
Ensembl chr 7:140,343,652...140,354,900 		JBrowse link
G Dio1 deiodinase, iodothyronine, type I decreases activity ISO o-Phthalaldehyde results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 4:107,148,662...107,164,365
Ensembl chr 4:107,148,662...107,164,366 		JBrowse link
G Dio2 deiodinase, iodothyronine, type II decreases activity ISO o-Phthalaldehyde results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr12:90,691,326...90,705,812
Ensembl chr12:90,691,326...90,705,812 		JBrowse link
G Dio3 deiodinase, iodothyronine type III decreases activity ISO o-Phthalaldehyde results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr12:110,245,664...110,247,531
Ensembl chr12:110,245,502...110,247,531 		JBrowse link
G E2f1 E2F transcription factor 1 affects expression EXP o-Phthalaldehyde affects the expression of E2F1 mRNA CTD PMID:22302311 NCBI chr 2:154,401,320...154,411,812
Ensembl chr 2:154,401,327...154,411,812 		JBrowse link
G Fabp7 fatty acid binding protein 7, brain affects expression EXP o-Phthalaldehyde affects the expression of FABP7 mRNA CTD PMID:22302311 NCBI chr10:57,661,019...57,664,546
Ensembl chr10:57,660,977...57,664,546 		JBrowse link
G Fxyd4 FXYD domain-containing ion transport regulator 4 affects expression EXP o-Phthalaldehyde affects the expression of FXYD4 mRNA CTD PMID:22302311 NCBI chr 6:117,910,519...117,914,668
Ensembl chr 6:117,910,520...117,914,653 		JBrowse link
G Gzmb granzyme B affects expression EXP o-Phthalaldehyde affects the expression of GZMB mRNA CTD PMID:22302311 NCBI chr14:56,496,293...56,499,791
Ensembl chr14:56,496,295...56,499,717 		JBrowse link
G Ifng interferon gamma increases expression EXP o-Phthalaldehyde results in increased expression of IFNG mRNA CTD PMID:21785612 NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797 		JBrowse link
G Iglv1 immunoglobulin lambda variable 1 affects expression EXP o-Phthalaldehyde affects the expression of IGLV1 mRNA CTD PMID:22302311 NCBI chr16:18,903,767...18,904,210
Ensembl chr16:18,903,767...18,904,250 		JBrowse link
G Il10 interleukin 10 increases expression EXP o-Phthalaldehyde results in increased expression of IL10 mRNA CTD PMID:21785612 NCBI chr 1:130,947,459...130,952,707
Ensembl chr 1:130,947,582...130,952,711 		JBrowse link
G Il12b interleukin 12b affects expression EXP o-Phthalaldehyde affects the expression of IL12B mRNA CTD PMID:22302311 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il13 interleukin 13 increases expression EXP o-Phthalaldehyde results in increased expression of IL13 mRNA CTD PMID:21785612 NCBI chr11:53,522,150...53,525,529
Ensembl chr11:53,522,151...53,525,529 		JBrowse link
G Il1b interleukin 1 beta increases expression EXP o-Phthalaldehyde results in increased expression of IL1B mRNA CTD PMID:21785612 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il21 interleukin 21 affects expression EXP o-Phthalaldehyde affects the expression of IL21 mRNA CTD PMID:22302311 NCBI chr 3:37,276,908...37,286,785
Ensembl chr 3:37,276,908...37,286,785 		JBrowse link
G Il2ra interleukin 2 receptor, alpha chain affects expression EXP o-Phthalaldehyde affects the expression of IL2RA mRNA CTD PMID:22302311 NCBI chr 2:11,647,603...11,698,005
Ensembl chr 2:11,647,618...11,698,004 		JBrowse link
G Il4 interleukin 4 affects expression
increases expression		 EXP o-Phthalaldehyde affects the expression of IL4 mRNA
o-Phthalaldehyde results in increased expression of IL4 mRNA; o-Phthalaldehyde results in increased expression of IL4 protein		 CTD PMID:19110043 PMID:20176622 PMID:21785612 PMID:22302311 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il5 interleukin 5 increases expression EXP o-Phthalaldehyde results in increased expression of IL5 mRNA CTD PMID:19110043 PMID:21785612 NCBI chr11:53,611,621...53,615,930
Ensembl chr11:53,611,621...53,615,933 		JBrowse link
G Itgav integrin alpha V affects expression EXP o-Phthalaldehyde affects the expression of ITGAV mRNA CTD PMID:22302311 NCBI chr 2:83,554,796...83,637,261
Ensembl chr 2:83,554,741...83,637,260 		JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO o-Phthalaldehyde inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr10:3,490,274...3,504,880
Ensembl chr10:3,490,240...3,504,877 		JBrowse link
G Lgals7 lectin, galactose binding, soluble 7 affects expression EXP o-Phthalaldehyde affects the expression of LGALS7 mRNA CTD PMID:22302311 NCBI chr 7:28,563,258...28,565,711
Ensembl chr 7:28,563,278...28,565,709 		JBrowse link
G Mcpt1 mast cell protease 1 affects expression EXP o-Phthalaldehyde affects the expression of MCPT1 mRNA CTD PMID:22302311 NCBI chr14:56,255,421...56,257,848
Ensembl chr14:56,255,428...56,257,841 		JBrowse link
G Mcpt8 mast cell protease 8 affects expression EXP o-Phthalaldehyde affects the expression of MCPT8 mRNA CTD PMID:22302311 NCBI chr14:56,319,620...56,322,951
Ensembl chr14:56,319,623...56,322,730 		JBrowse link
G Mki67 antigen identified by monoclonal antibody Ki 67 affects expression EXP o-Phthalaldehyde affects the expression of MKI67 mRNA CTD PMID:22302311 NCBI chr 7:135,291,513...135,318,286
Ensembl chr 7:135,291,513...135,318,090 		JBrowse link
G Nts neurotensin affects expression EXP o-Phthalaldehyde affects the expression of NTS mRNA CTD PMID:22302311 NCBI chr10:102,317,617...102,326,294
Ensembl chr10:102,317,617...102,326,347 		JBrowse link
G Thbs1 thrombospondin 1 affects expression EXP o-Phthalaldehyde affects the expression of THBS1 mRNA CTD PMID:22302311 NCBI chr 2:117,942,357...117,957,614
Ensembl chr 2:117,942,357...117,957,614 		JBrowse link
G Thbs4 thrombospondin 4 affects expression EXP o-Phthalaldehyde affects the expression of THBS4 mRNA CTD PMID:22302311 NCBI chr13:92,888,094...92,931,326
Ensembl chr13:92,888,098...92,931,326 		JBrowse link
G Timd2 T cell immunoglobulin and mucin domain containing 2 affects expression EXP o-Phthalaldehyde affects the expression of TIMD2 mRNA CTD PMID:22302311 NCBI chr11:46,559,787...46,597,934
Ensembl chr11:46,559,787...46,597,888 		JBrowse link
G Timp1 tissue inhibitor of metalloproteinase 1 affects expression EXP o-Phthalaldehyde affects the expression of TIMP1 mRNA CTD PMID:22302311 NCBI chr  X:20,736,524...20,740,972
Ensembl chr  X:20,736,405...20,740,974 		JBrowse link
G Tnf tumor necrosis factor increases expression EXP o-Phthalaldehyde results in increased expression of TNF mRNA CTD PMID:21785612 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trp53 transformation related protein 53 affects activity ISO o-Phthalaldehyde affects the activity of TP53 protein CTD PMID:35435491 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trpm6 transient receptor potential cation channel, subfamily M, member 6 affects expression EXP o-Phthalaldehyde affects the expression of TRPM6 mRNA CTD PMID:22302311 NCBI chr19:18,707,566...18,869,885
Ensembl chr19:18,727,347...18,869,875 		JBrowse link
vanillin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO vanillin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of ACHE protein] CTD PMID:33823243 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Akr1c21 aldo-keto reductase family 1, member C21 increases expression ISO vanillin results in increased expression of AKR1C2 mRNA CTD PMID:20491607 NCBI chr13:4,624,074...4,636,542
Ensembl chr13:4,624,074...4,636,540 		JBrowse link
G Car1 carbonic anhydrase 1 decreases activity ISO vanillin results in decreased activity of CA1 protein CTD PMID:19231207 NCBI chr 3:14,831,274...14,873,425
Ensembl chr 3:14,831,276...14,873,428 		JBrowse link
G Car2 carbonic anhydrase 2 decreases activity ISO vanillin results in decreased activity of CA2 protein CTD PMID:19231207 NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO vanillin inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; vanillin inhibits the reaction [Methotrexate results in increased activity of CASP3 protein] CTD PMID:29216766 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Cat catalase multiple interactions EXP
ISO		 vanillin inhibits the reaction [potassium bromate results in increased activity of CAT protein]
vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of CAT protein]
vanillin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased activity of CAT protein]		 CTD PMID:26296324 PMID:33823243 PMID:37336463 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO vanillin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CCL2 protein] CTD PMID:36416909 NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279 		JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression ISO vanillin results in decreased expression of CCN2 mRNA CTD PMID:17178418 NCBI chr10:24,471,340...24,474,581
Ensembl chr10:24,471,340...24,474,581 		JBrowse link
G Clk2 CDC-like kinase 2 increases expression ISO vanillin results in increased expression of CLK2 mRNA CTD PMID:17178418 NCBI chr 3:89,072,102...89,084,394
Ensembl chr 3:89,072,102...89,084,228 		JBrowse link
G Cst3 cystatin C multiple interactions ISO vanillin inhibits the reaction [Cisplatin results in increased expression of CST3 protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of CST3 protein] CTD PMID:29216766 NCBI chr 2:148,713,642...148,717,432
Ensembl chr 2:148,713,642...148,717,612 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression
multiple interactions		 ISO vanillin results in increased expression of CXCL8 mRNA
vanillin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of CXCL8 protein]		 CTD PMID:20491607 PMID:21920952 PMID:36416909 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression ISO vanillin results in increased expression of CYP1A1 mRNA CTD PMID:20491607 NCBI chr 9:57,595,211...57,611,107
Ensembl chr 9:57,595,211...57,611,107 		JBrowse link
G Cyp2a5 cytochrome P450, family 2, subfamily a, polypeptide 5 decreases activity
multiple interactions		 ISO vanillin results in decreased activity of CYP2A6 protein
[[vanillin results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin] which results in decreased chemical synthesis of 3-cyano-7-hydroxycoumarin; [vanillin results in decreased activity of CYP2A6 protein] which results in decreased hydroxylation of 3-cyanocoumarin		 CTD PMID:32496054 NCBI chr 7:26,534,764...26,542,689
Ensembl chr 7:26,534,730...26,542,973 		JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 increases expression ISO vanillin results in increased expression of DDIT4 mRNA CTD PMID:17178418 NCBI chr10:59,785,497...59,787,592
Ensembl chr10:59,785,491...59,787,656 		JBrowse link
G Dnmt3b DNA methyltransferase 3B decreases expression ISO vanillin results in decreased expression of DNMT3B mRNA CTD PMID:17178418 NCBI chr 2:153,491,332...153,529,650
Ensembl chr 2:153,491,370...153,529,650 		JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression ISO vanillin results in decreased expression of DUSP6 mRNA CTD PMID:17178418 NCBI chr10:99,098,676...99,103,351
Ensembl chr10:99,099,093...99,103,351 		JBrowse link
G Fasl Fas ligand multiple interactions ISO vanillin inhibits the reaction [Cisplatin results in increased expression of FASLG protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of FASLG protein] CTD PMID:29216766 NCBI chr 1:161,608,260...161,616,064
Ensembl chr 1:161,608,258...161,616,064 		JBrowse link
G Fbp1 fructose bisphosphatase 1 affects binding ISO vanillin binds to FBP1 protein CTD PMID:33823243 NCBI chr13:63,012,567...63,036,112
Ensembl chr13:63,012,567...63,036,096 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 decreases expression ISO vanillin results in decreased expression of FGFR2 mRNA CTD PMID:17178418 NCBI chr 7:129,764,181...129,868,538
Ensembl chr 7:129,764,181...132,725,079 		JBrowse link
G Fzd2 frizzled class receptor 2 decreases expression ISO vanillin results in decreased expression of FZD2 mRNA CTD PMID:17178418 NCBI chr11:102,495,257...102,498,884
Ensembl chr11:102,495,222...102,498,884 		JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 affects binding ISO vanillin binds to G6PC1 protein CTD PMID:33823243 NCBI chr11:101,258,542...101,268,729
Ensembl chr11:101,258,387...101,268,729 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked multiple interactions ISO vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of G6PD protein] CTD PMID:37336463 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase multiple interactions ISO vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of GAPDH protein] CTD PMID:37336463 NCBI chr 6:125,138,812...125,143,450
Ensembl chr 6:125,138,678...125,143,430 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO vanillin results in increased expression of GCLC mRNA CTD PMID:17178418 NCBI chr 9:77,661,817...77,701,771
Ensembl chr 9:77,661,817...77,701,767 		JBrowse link
G Gclm glutamate-cysteine ligase, modifier subunit increases expression ISO vanillin results in increased expression of GCLM mRNA CTD PMID:17178418 NCBI chr 3:122,039,206...122,060,864
Ensembl chr 3:122,039,206...122,064,381 		JBrowse link
G Glo1 glyoxalase 1 multiple interactions ISO vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of GLO1 protein] CTD PMID:37336463 NCBI chr17:30,811,835...30,831,633
Ensembl chr17:30,803,910...30,845,845 		JBrowse link
G Gsr glutathione reductase multiple interactions ISO vanillin inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein] CTD PMID:37336463 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO vanillin results in increased expression of HMOX1 mRNA CTD PMID:17178418 NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217 		JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 decreases mutagenesis ISO vanillin results in decreased mutagenesis of HPRT1 gene CTD PMID:17178418 NCBI chr  X:52,076,955...52,110,537
Ensembl chr  X:52,077,014...52,110,536 		JBrowse link
G Hspa1b heat shock protein 1B increases expression ISO vanillin results in increased expression of HSPA1B mRNA CTD PMID:17178418 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214 		JBrowse link
G Il12b interleukin 12b multiple interactions ISO vanillin promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL12B protein] CTD PMID:36416909 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il18 interleukin 18 multiple interactions ISO vanillin inhibits the reaction [Cisplatin results in increased expression of IL18 protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of IL18 protein] CTD PMID:29216766 NCBI chr 9:50,466,000...50,493,141
Ensembl chr 9:50,466,127...50,493,140 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP vanillin inhibits the reaction [potassium bromate results in increased expression of IL1B mRNA] CTD PMID:26296324 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP vanillin inhibits the reaction [potassium bromate results in increased expression of IL6 mRNA] CTD PMID:26296324 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Insig1 insulin induced gene 1 decreases expression ISO vanillin results in decreased expression of INSIG1 mRNA CTD PMID:17178418 NCBI chr 5:28,276,410...28,283,660
Ensembl chr 5:28,276,361...28,283,660 		JBrowse link
G Jund jun D proto-oncogene decreases expression ISO vanillin results in decreased expression of JUND mRNA CTD PMID:17178418 NCBI chr 8:71,150,389...71,153,265
Ensembl chr 8:71,151,599...71,153,265 		JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO vanillin inhibits the reaction [Cisplatin results in increased expression of LCN2 protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of LCN2 protein] CTD PMID:29216766 NCBI chr 2:32,274,649...32,277,751
Ensembl chr 2:32,274,645...32,278,264 		JBrowse link
G Map2k2 mitogen-activated protein kinase kinase 2 decreases expression ISO vanillin results in decreased expression of MAP2K2 mRNA CTD PMID:17178418 NCBI chr10:80,941,749...80,960,531
Ensembl chr10:80,941,749...80,969,809 		JBrowse link
G Mark4 MAP/microtubule affinity regulating kinase 4 decreases expression ISO vanillin results in decreased expression of MARK4 mRNA CTD PMID:17178418 NCBI chr 7:19,159,027...19,193,255
Ensembl chr 7:19,158,700...19,192,746 		JBrowse link
G Mt1 metallothionein 1 multiple interactions EXP vanillin inhibits the reaction [potassium bromate results in increased expression of MT1 mRNA] CTD PMID:27074584 NCBI chr 8:94,905,214...94,906,955
Ensembl chr 8:94,905,710...94,906,955 		JBrowse link
G Mt2 metallothionein 2 increases expression
multiple interactions		 ISO
EXP		 vanillin results in increased expression of MT2A mRNA
vanillin inhibits the reaction [potassium bromate results in increased expression of MT2 mRNA]		 CTD PMID:20491607 PMID:27074584 NCBI chr 8:94,899,246...94,900,195
Ensembl chr 8:94,899,292...94,900,196 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO vanillin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of NOS2 protein] CTD PMID:29216766 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Ppp1r10 protein phosphatase 1, regulatory subunit 10 decreases expression ISO vanillin results in decreased expression of PPP1R10 mRNA CTD PMID:17178418 NCBI chr17:36,227,404...36,243,175
Ensembl chr17:36,227,326...36,243,175 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP vanillin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; vanillin inhibits the reaction [potassium bromate results in increased expression of PTGS2 mRNA] CTD PMID:17465205 PMID:26296324 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Pygl liver glycogen phosphorylase affects binding ISO vanillin binds to PYGL protein CTD PMID:33823243 NCBI chr12:70,237,589...70,274,457
Ensembl chr12:70,237,585...70,278,262 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions ISO vanillin inhibits the reaction [Cisplatin results in increased expression of RELA protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of RELA protein] CTD PMID:29216766 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Slc35d2 solute carrier family 35, member D2 decreases expression ISO vanillin results in decreased expression of SLC35D2 mRNA CTD PMID:17178418 NCBI chr13:64,244,122...64,277,195
Ensembl chr13:64,244,122...64,277,182 		JBrowse link
G Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 increases expression ISO vanillin results in increased expression of SLC7A11 mRNA CTD PMID:17178418 NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063 		JBrowse link
G Tgfb1i1 transforming growth factor beta 1 induced transcript 1 decreases expression ISO vanillin results in decreased expression of TGFB1I1 mRNA CTD PMID:17178418 NCBI chr 7:127,845,963...127,852,884
Ensembl chr 7:127,845,984...127,854,871 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 vanillin inhibits the reaction [potassium bromate results in increased expression of TNF mRNA]
vanillin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]
vanillin inhibits the reaction [Cisplatin results in increased expression of TNF protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of TNF protein]		 CTD PMID:26296324 PMID:29216766 PMID:36416909 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trim16 tripartite motif-containing 16 increases expression ISO vanillin results in increased expression of TRIM16 mRNA CTD PMID:17178418 NCBI chr11:62,711,034...62,733,774
Ensembl chr11:62,711,057...62,741,634 		JBrowse link
G Trp53 transformation related protein 53 decreases expression ISO vanillin results in decreased expression of TP53 mRNA CTD PMID:17178418 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity EXP vanillin results in increased activity of TRPV3 protein CTD PMID:16617338 NCBI chr11:73,158,315...73,191,194
Ensembl chr11:73,158,214...73,191,189 		JBrowse link
G Ugp2 UDP-glucose pyrophosphorylase 2 increases expression ISO vanillin results in increased expression of UGP2 mRNA CTD PMID:17178418 NCBI chr11:21,271,126...21,321,267
Ensembl chr11:21,271,138...21,321,201 		JBrowse link
G Ugt1a10 UDP glycosyltransferase 1 family, polypeptide A10 increases glucuronidation ISO UGT1A10 protein results in increased glucuronidation of vanillin CTD PMID:15117964 NCBI chr 1:87,983,133...88,147,724
Ensembl chr 1:87,983,110...88,146,726 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 increases glucuronidation ISO UGT1A3 protein results in increased glucuronidation of vanillin CTD PMID:15117964 NCBI chr 1:88,128,333...88,147,724
Ensembl chr 1:88,128,323...88,146,719 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    role 22194
      application 21744
        solvent 18197
          formic acid 9159
            formyl group 9120
              aldehyde 9120
                arenecarbaldehyde 146
                  1,3-Dimethyl-1H-pyrazole-4-carbaldehyde 0
                  1,3-thiazole-2-carbaldehyde + 0
                  1-Ethyl-1H-pyrrole-2-carboxaldehyde 0
                  1-Methyl-2-pyrrolecarboxaldehyde 0
                  1-acetylindole-3-carboxaldehyde 0
                  2,5-diformylfuran 0
                  2,5-dimethyl-1-(phenylmethyl)pyrrole-3,4-dicarboxaldehyde 0
                  2-(dihydroxymethyl)-5-formylfuran 0
                  4'-methyl-2,2'-bipyridine-4-carboxaldehyde 0
                  4-(phosphooxymethyl)-2-furancarboxaldehyde 0
                  4-Hydroxy-2,2'-bipyrrole-5-carbaldehyde 0
                  4-ethylpyrrole-2-carboxaldehyde 0
                  5-(\{5-[(5-(hydroxymethyl)furan-2-yl)methoxy(methoxymethyl)]furan-2-yl\}methoxy(methoxymethyl))furan-2-carbaldehyde 0
                  5-Methoxymethyl furfural 0
                  5-Sulfoxymethylfurfural 0
                  5-[(5-hydroxymethyl-furan-2-yl)methoxy-methoxymethyl]-furan-2-carbaldehyde 0
                  5-formyl-2-furoic acid 0
                  5-hydroxymethylfurfural 3
                  8-formyl-8-demethylriboflavin 5'-phosphate 0
                  Baldrinal 0
                  Ganoine 0
                  Irpexlacte B 0
                  Irpexlacte C 0
                  Jiangrine E 0
                  N-[4-(2-formyl-5-hydroxymethyl-pyrrol-1-yl)-butyl]-acetamide 0
                  N-[5-(2-formyl-5-hydroxymethyl-pyrrol-1-yl)-pentyl]-acetamide 0
                  Phlebopine A 0
                  Phlebopine B 0
                  Viburtinal 0
                  aromatic (S)-hydroxynitrile 0
                  benzaldehydes + 141
                  cyathusal A 0
                  cyathusal B 0
                  cyathusal C 0
                  demethylzeylasteral 0
                  grixazone A 0
                  kadsurenin M 0
                  mycobilin a 0
                  mycobilin b 0
                  naphthaldehydes + 1
                  oncrasin-1 1
                  piperonal 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    p-block element atom 22104
                      carbon group element atom 21904
                        carbon atom 21859
                          organic molecular entity 21830
                            heteroorganic entity 21482
                              organochalcogen compound 20966
                                organooxygen compound 20806
                                  carbon oxoacid 19593
                                    carboxylic acid 19589
                                      carboacyl group 18277
                                        univalent carboacyl group 18277
                                          formyl group 9120
                                            aldehyde 9120
                                              arenecarbaldehyde 146
                                                1,3-Dimethyl-1H-pyrazole-4-carbaldehyde 0
                                                1,3-thiazole-2-carbaldehyde + 0
                                                1-Ethyl-1H-pyrrole-2-carboxaldehyde 0
                                                1-Methyl-2-pyrrolecarboxaldehyde 0
                                                1-acetylindole-3-carboxaldehyde 0
                                                2,5-diformylfuran 0
                                                2,5-dimethyl-1-(phenylmethyl)pyrrole-3,4-dicarboxaldehyde 0
                                                2-(dihydroxymethyl)-5-formylfuran 0
                                                4'-methyl-2,2'-bipyridine-4-carboxaldehyde 0
                                                4-(phosphooxymethyl)-2-furancarboxaldehyde 0
                                                4-Hydroxy-2,2'-bipyrrole-5-carbaldehyde 0
                                                4-ethylpyrrole-2-carboxaldehyde 0
                                                5-(\{5-[(5-(hydroxymethyl)furan-2-yl)methoxy(methoxymethyl)]furan-2-yl\}methoxy(methoxymethyl))furan-2-carbaldehyde 0
                                                5-Methoxymethyl furfural 0
                                                5-Sulfoxymethylfurfural 0
                                                5-[(5-hydroxymethyl-furan-2-yl)methoxy-methoxymethyl]-furan-2-carbaldehyde 0
                                                5-formyl-2-furoic acid 0
                                                5-hydroxymethylfurfural 3
                                                8-formyl-8-demethylriboflavin 5'-phosphate 0
                                                Baldrinal 0
                                                Ganoine 0
                                                Irpexlacte B 0
                                                Irpexlacte C 0
                                                Jiangrine E 0
                                                N-[4-(2-formyl-5-hydroxymethyl-pyrrol-1-yl)-butyl]-acetamide 0
                                                N-[5-(2-formyl-5-hydroxymethyl-pyrrol-1-yl)-pentyl]-acetamide 0
                                                Phlebopine A 0
                                                Phlebopine B 0
                                                Viburtinal 0
                                                aromatic (S)-hydroxynitrile 0
                                                benzaldehydes + 141
                                                cyathusal A 0
                                                cyathusal B 0
                                                cyathusal C 0
                                                demethylzeylasteral 0
                                                grixazone A 0
                                                kadsurenin M 0
                                                mycobilin a 0
                                                mycobilin b 0
                                                naphthaldehydes + 1
                                                oncrasin-1 1
                                                piperonal 0
paths to the root