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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(-)-anisomycin
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Accession:CHEBI:338412 term browser browse the term
Definition:An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
Synonyms:related_synonym: (2R,3S,4S)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidin-3-yl acetate;   1,4,5-Trideoxy-1,4-imino-5-(p-methoxyphenyl)-D-xylo-pentitol 3-acetate;   2-(p-Methoxybenzyl)-3,4-pyrrolidinediol 3-acetate;   2-p-Methoxyphenylmethyl-3-acetoxy-4-hydroxypyrrolidine;   Formula=C14H19NO4;   InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1;   InChIKey=YKJYKKNCCRKFSL-RDBSUJKOSA-N;   SMILES=COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(C)=O)cc1
 alt_id: CHEBI:2737;   CHEBI:40748
 xref: Beilstein:20705;   CAS:22862-76-6;   DrugBank:DB07374;   KEGG:C11281;   LINCS:LSM-4047
 xref_mesh: MESH:D000841
 xref: PDBeChem:ANM;   PMID:16005213;   PMID:22004851;   PMID:23192275;   PMID:23525555;   PMID:23582782;   PMID:24333448;   PMID:6834379;   Reaxys:20705;   Wikipedia:Anisomycin


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(-)-anisomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions
ISO Anisomycin results in increased expression of ABCC3 mRNA
SB 203580 inhibits the reaction [Anisomycin results in increased expression of ABCC3 mRNA]
CTD PMID:27507784 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Ager advanced glycosylation end product-specific receptor increases expression ISO Anisomycin results in increased expression of AGER protein CTD PMID:33075463 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Ago2 argonaute RISC catalytic component 2 increases phosphorylation ISO Anisomycin results in increased phosphorylation of AGO2 protein CTD PMID:18476811 NCBI chr 7:105,018,202...105,105,120
Ensembl chr 7:105,029,120...105,104,974
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
decreases expression
ISO Anisomycin promotes the reaction [Tetrachlorodibenzodioxin results in increased degradation of and results in decreased expression of AHR protein]
Anisomycin results in decreased expression of AHR protein
CTD PMID:15385644 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Atf1 activating transcription factor 1 increases phosphorylation
multiple interactions
ISO Anisomycin results in increased phosphorylation of ATF1 protein
[SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Anisomycin results in increased phosphorylation of ATF1 protein]; SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of ATF1 protein]
CTD PMID:12660819 NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670
JBrowse link
G Atf2 activating transcription factor 2 increases phosphorylation
multiple interactions
ISO Anisomycin results in increased phosphorylation of ATF2 protein
pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of ATF2 protein]; SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of ATF2 protein]
CTD PMID:12663670 PMID:28975372 NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
increases expression
ISO [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of ATF3 mRNA] CTD PMID:19101521 PMID:22003189 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atg13 autophagy related 13 decreases expression ISO Anisomycin results in decreased expression of ATG13 protein CTD PMID:27629431 NCBI chr 3:77,647,069...77,681,028
Ensembl chr 3:77,645,790...77,681,043
JBrowse link
G Atg4b autophagy related 4B, cysteine peptidase decreases expression ISO Anisomycin results in decreased expression of ATG4B protein CTD PMID:27629431 NCBI chr 9:94,282,417...94,314,109
Ensembl chr 9:94,282,509...94,314,103
JBrowse link
G Bach2 BTB domain and CNC homolog 2 increases expression ISO Anisomycin results in increased expression of BACH2 mRNA CTD PMID:24247028 NCBI chr 5:46,632,338...46,982,676
Ensembl chr 5:46,638,317...46,977,877
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Anisomycin promotes the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein] CTD PMID:33684387 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [Colistin co-treated with Anisomycin] results in increased phosphorylation of BCL2 protein CTD PMID:28842171 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Becn1 beclin 1 multiple interactions EXP Anisomycin promotes the reaction [Colistin results in increased expression of BECN1 protein] CTD PMID:28842171 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO Anisomycin results in increased cleavage of and results in increased activity of BID protein CTD PMID:18241849 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Anisomycin promotes the reaction [(+)-JQ1 compound results in decreased expression of BIRC5 protein] CTD PMID:23872705 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
ISO
EXP
Anisomycin promotes the reaction [Indomethacin results in increased activity of CASP3 protein]; Anisomycin results in increased cleavage of and results in increased activity of CASP3 protein
Anisomycin promotes the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]
Anisomycin results in increased expression of CASP3 protein modified form
[Colistin co-treated with Anisomycin] results in increased cleavage of CASP3 protein
CTD PMID:17341418 PMID:18241849 PMID:28842171 PMID:29944914 PMID:33684387 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp6 caspase 6 multiple interactions ISO Anisomycin promotes the reaction [Indomethacin results in increased activity of CASP6 protein] CTD PMID:17341418 NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
JBrowse link
G Casp8 caspase 8 increases activity ISO Anisomycin results in increased activity of CASP8 protein CTD PMID:18241849 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Anisomycin promotes the reaction [Indomethacin results in increased activity of CASP9 protein] CTD PMID:17341418 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cav1 caveolin 1 multiple interactions
increases phosphorylation
ISO wogonin inhibits the reaction [Anisomycin results in increased phosphorylation of CAV1 protein] CTD PMID:23246481 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Anisomycin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Anisomycin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Anisomycin results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression ISO Anisomycin results in increased expression of CD55 mRNA CTD PMID:24247028 NCBI chr13:41,857,242...41,885,966
Ensembl chr13:41,857,395...41,885,831
JBrowse link
G Cd69 Cd69 molecule increases expression ISO Anisomycin results in increased expression of CD69 mRNA CTD PMID:24247028 NCBI chr 4:162,725,446...162,733,364
Ensembl chr 4:162,725,446...162,733,542
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
ISO Anisomycin results in increased phosphorylation of CREB1 protein
SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of CREB1 protein]
CTD PMID:12660819 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Crebbp CREB binding protein increases expression ISO Anisomycin results in increased expression of CREBBP mRNA CTD PMID:24247028 NCBI chr10:11,335,551...11,461,888
Ensembl chr10:11,335,953...11,461,888
JBrowse link
G Cs citrate synthase multiple interactions ISO Anisomycin affects the reaction [triethylene glycol dimethacrylate affects the activity of CS protein] CTD PMID:33684387 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
increases expression
ISO [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL1 mRNA] CTD PMID:22003189 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions
ISO Anisomycin results in increased expression of CXCL1 mRNA
[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL1 mRNA]
CTD PMID:22003189 NCBI chr14:17,270,146...17,289,458
Ensembl chr14:17,270,146...17,289,511
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Anisomycin results in increased expression of CYP1A1 mRNA
[Anisomycin co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP1A1 mRNA
CTD PMID:15385644 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions ISO Anisomycin inhibits the reaction [Tretinoin results in increased expression of CYP26A1 mRNA] CTD PMID:16038797 NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO Anisomycin promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B6 mRNA] CTD PMID:23539296 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime co-treated with Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2B6 mRNA CTD PMID:23539296 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Anisomycin results in increased expression of DDIT3 mRNA CTD PMID:18241849 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression ISO Anisomycin results in decreased expression of DUSP6 mRNA CTD PMID:24247028 NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185
JBrowse link
G Dusp8 dual specificity phosphatase 8 multiple interactions ISO DUSP8 protein inhibits the reaction [Anisomycin results in increased phosphorylation of JUN protein]; DUSP8 protein inhibits the reaction [Anisomycin results in increased phosphorylation of NR3C1 protein] CTD PMID:32780722 NCBI chr 1:197,167,392...197,184,285
Ensembl chr 1:197,169,422...197,182,921
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO SB 203580 inhibits the reaction [Anisomycin results in increased expression of EGR1 mRNA] CTD PMID:9671412 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases phosphorylation
multiple interactions
ISO Anisomycin results in increased phosphorylation of EIF4E protein
SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of EIF4E protein]
CTD PMID:9545260 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Elk1 ETS transcription factor ELK1 increases phosphorylation
multiple interactions
ISO Anisomycin results in increased phosphorylation of ELK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Anisomycin results in increased phosphorylation of ELK1 protein]; pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of ELK1 protein]
CTD PMID:12660819 NCBI chr  X:1,138,826...1,155,713
Ensembl chr  X:1,139,756...1,155,713
JBrowse link
G Evi2a ecotropic viral integration site 2A increases expression ISO Anisomycin results in increased expression of EVI2A mRNA CTD PMID:24247028 NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843
JBrowse link
G Fas Fas cell surface death receptor increases localization ISO Anisomycin results in increased localization of FAS protein CTD PMID:18241849 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Anisomycin results in increased expression of FOS mRNA CTD PMID:12660819 PMID:18241849 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Anisomycin results in increased expression of FOSB mRNA CTD PMID:18241849 NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions ISO Anisomycin inhibits the reaction [GHRL protein inhibits the reaction [Uranium results in decreased expression of and results in decreased secretion of TNFRSF11B protein]]; Anisomycin inhibits the reaction [GHRL protein inhibits the reaction [Uranium results in increased expression of and results in increased secretion of TNFSF11 protein]] CTD PMID:29477364 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
JBrowse link
G Hoxa1 homeobox A1 multiple interactions ISO Anisomycin promotes the reaction [Tretinoin results in increased expression of HOXA1 mRNA] CTD PMID:16038797 NCBI chr 4:81,255,814...81,258,504
Ensembl chr 4:81,255,883...81,258,504
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO Anisomycin results in decreased expression of HSPA5 mRNA; Anisomycin results in decreased expression of HSPA5 protein CTD PMID:25324550 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions EXP Anisomycin inhibits the reaction [Cocaine results in increased expression of HSPA9 protein] CTD PMID:12422371 NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Anisomycin inhibits the reaction [TNF protein results in increased expression of and affects the localization of ICAM1 protein] CTD PMID:21448188 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Anisomycin promotes the reaction [IGF1 protein results in increased phosphorylation of JUN protein] CTD PMID:11278392 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Anisomycin results in increased expression of IL1B protein CTD PMID:15019843 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Anisomycin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation
increases expression
ISO
EXP
Anisomycin promotes the reaction [IGF1 protein results in increased phosphorylation of JUN protein]; DUSP8 protein inhibits the reaction [Anisomycin results in increased phosphorylation of JUN protein]
Anisomycin results in increased expression of JUN mRNA
CTD PMID:9751194 PMID:11278392 PMID:15019843 PMID:18241849 PMID:21815634 More... NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression ISO Anisomycin results in increased expression of JUND mRNA CTD PMID:18241849 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO Anisomycin results in increased expression of MAFF mRNA CTD PMID:24247028 NCBI chr 7:110,912,499...110,923,851
Ensembl chr 7:110,912,499...110,923,851
JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 multiple interactions ISO MAP3K20 protein promotes the reaction [Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; quinoline analog inhibits the reaction [MAP3K20 protein promotes the reaction [Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein]] CTD PMID:15737997 NCBI chr 3:57,128,561...57,289,943
Ensembl chr 3:57,130,551...57,289,626
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases expression
increases phosphorylation
increases activity
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK1 protein]
Anisomycin results in increased expression of MAPK1 protein modified form
Anisomycin results in increased activity of MAPK1 protein
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [Anisomycin results in increased phosphorylation of MAPK1 protein]
CTD PMID:9671412 PMID:11551972 PMID:12660819 PMID:15772366 PMID:25233930 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions
increases activity
ISO Dicumarol inhibits the reaction [Anisomycin results in increased activity of MAPK10 protein] CTD PMID:10531305 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
increases phosphorylation
ISO
EXP
Anisomycin results in increased phosphorylation of and results in increased activity of MAPK14 protein
Anisomycin results in increased phosphorylation of MAPK14 protein
MAPK14 protein affects the reaction [Anisomycin results in increased activity of MAPKAPK2 protein]
CTD PMID:10704466 PMID:15961565 PMID:16038797 PMID:16364386 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases expression
increases phosphorylation
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK3 protein]
Anisomycin results in increased expression of MAPK3 protein modified form
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK3 protein]
CTD PMID:12660819 PMID:15772366 PMID:25233930 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
increases activity
multiple interactions
ISO
EXP
Anisomycin results in increased phosphorylation of MAPK8 protein
Anisomycin results in increased activity of MAPK8 protein
Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein; MAP3K20 protein promotes the reaction [Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; quinoline analog inhibits the reaction [MAP3K20 protein promotes the reaction [Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein]]
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK8 protein]
CTD PMID:12902192 PMID:12967334 PMID:15737997 PMID:15772366 PMID:15961565 More... NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
ISO 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK9 protein] CTD PMID:12967334 PMID:15772366 PMID:16038797 PMID:33075463 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 increases activity
multiple interactions
ISO Anisomycin results in increased activity of MAPKAPK2 protein
MAPK14 protein affects the reaction [Anisomycin results in increased activity of MAPKAPK2 protein]
CTD PMID:10704466 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 increases activity
multiple interactions
ISO Anisomycin results in increased activity of MKNK1 protein
SB 203580 inhibits the reaction [Anisomycin results in increased activity of MKNK1 protein]
CTD PMID:9545260 NCBI chr 5:129,318,128...129,357,641
Ensembl chr 5:129,318,170...129,357,639
JBrowse link
G Mrps30 mitochondrial ribosomal protein S30 increases expression ISO Anisomycin results in increased expression of MRPS30 mRNA CTD PMID:24247028 NCBI chr 2:50,456,253...50,463,128
Ensembl chr 2:50,456,255...50,463,105
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Anisomycin results in increased expression of MYC mRNA CTD PMID:24247028 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 multiple interactions ISO [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of ATF3 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL1 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL8 mRNA] CTD PMID:22003189 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2A7 mRNA]; [Anisomycin co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2C9 mRNA; [Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2A7 mRNA; Anisomycin promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B6 mRNA]
[6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime co-treated with Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2B6 mRNA
CTD PMID:23539296 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 increases phosphorylation
multiple interactions
ISO Anisomycin results in increased phosphorylation of NR3C1 protein
DUSP8 protein inhibits the reaction [Anisomycin results in increased phosphorylation of NR3C1 protein]
CTD PMID:32780722 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP [Colistin co-treated with Anisomycin] results in increased cleavage of PARP1 protein CTD PMID:28842171 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Anisomycin results in increased expression of PMAIP1 mRNA CTD PMID:24247028 NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429
JBrowse link
G Postn periostin increases expression EXP Anisomycin results in increased expression of POSTN mRNA CTD PMID:15121739 NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 multiple interactions EXP Anisomycin inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein] CTD PMID:17623046 NCBI chr 1:97,620,638...97,681,186
Ensembl chr 1:97,620,642...97,679,882
JBrowse link
G Rarb retinoic acid receptor, beta multiple interactions ISO Anisomycin promotes the reaction [Tretinoin results in increased expression of RARB mRNA] CTD PMID:16038797 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Ret ret proto-oncogene decreases expression EXP Anisomycin results in decreased expression of RET protein CTD PMID:17555550 NCBI chr 4:151,325,969...151,368,176
Ensembl chr 4:151,326,431...151,368,176
JBrowse link
G Rhoh ras homolog family member H increases expression ISO Anisomycin results in increased expression of RHOH mRNA CTD PMID:24247028 NCBI chr14:42,341,135...42,371,971
Ensembl chr14:42,337,751...42,386,369
JBrowse link
G Rora RAR-related orphan receptor A increases expression ISO Anisomycin results in increased expression of RORA mRNA CTD PMID:24247028 NCBI chr 8:69,301,635...70,034,741
Ensembl chr 8:69,301,733...70,025,931
JBrowse link
G Rxra retinoid X receptor alpha increases phosphorylation
multiple interactions
ISO Anisomycin results in increased phosphorylation of RXRA protein
pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of RXRA protein]
CTD PMID:16038797 PMID:16184197 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP
ISO
Anisomycin promotes the reaction [Colistin results in increased degradation of SQSTM1 protein]
Anisomycin promotes the reaction [triethylene glycol dimethacrylate results in increased expression of SQSTM1 protein]
CTD PMID:28842171 PMID:33684387 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Srf serum response factor increases phosphorylation
multiple interactions
ISO Anisomycin results in increased phosphorylation of SRF protein
SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of SRF protein]
CTD PMID:12660819 NCBI chr 9:14,426,453...14,435,734
Ensembl chr 9:14,426,472...14,435,733
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Anisomycin promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA]; Anisomycin results in increased expression of and results in increased stability of STAR mRNA CTD PMID:15713539 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Anisomycin results in increased expression of TNF mRNA
Anisomycin inhibits the reaction [TNF protein results in increased expression of and affects the localization of ICAM1 protein]
CTD PMID:18241849 PMID:21448188 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions ISO Anisomycin inhibits the reaction [GHRL protein inhibits the reaction [Uranium results in decreased expression of and results in decreased secretion of TNFRSF11B protein]] CTD PMID:29477364 NCBI chr 7:85,566,520...85,594,526
Ensembl chr 7:85,566,520...85,594,538
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Anisomycin inhibits the reaction [GHRL protein inhibits the reaction [Uranium results in increased expression of and results in increased secretion of TNFSF11 protein]] CTD PMID:29477364 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression
decreases expression
ISO Anisomycin results in increased expression of TNFSF9 mRNA
Anisomycin results in decreased expression of TNFSF9 mRNA
CTD PMID:18241849 PMID:24247028 NCBI chr 9:1,944,017...1,946,351
Ensembl chr 9:1,944,017...1,946,345
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Anisomycin promotes the reaction [Colistin results in increased expression of TP53 protein] CTD PMID:28842171 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Anisomycin results in increased expression of TXNIP mRNA CTD PMID:10843682 NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 decreases expression ISO Anisomycin results in decreased expression of ULK1 protein CTD PMID:27629431 NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
JBrowse link
G Usp30 ubiquitin specific peptidase 30 increases expression ISO Anisomycin results in increased expression of USP30 mRNA CTD PMID:24247028 NCBI chr12:42,501,345...42,555,311
Ensembl chr12:42,501,348...42,555,616
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Anisomycin results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
G Xbp1 X-box binding protein 1 decreases splicing ISO Anisomycin results in decreased splicing of XBP1 mRNA CTD PMID:25324550 NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        antimicrobial agent 17400
          (-)-anisomycin 91
Path 2
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  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic molecule 19560
                              organic cyclic compound 19351
                                organic heterocyclic compound 18582
                                  organic heteromonocyclic compound 17081
                                    pyrrolidines 2265
                                      hydroxypyrrolidine 91
                                        monohydroxypyrrolidine 91
                                          (-)-anisomycin 91
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