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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:(-)-anisomycin
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Accession:CHEBI:338412 term browser browse the term
Definition:An antibiotic isolated from various Streptomyces species. It interferes with protein and DNA synthesis by inhibiting peptidyl transferase or the 80S ribosome system.
Synonyms:related_synonym: (2R,3S,4S)-4-hydroxy-2-(4-methoxybenzyl)pyrrolidin-3-yl acetate;   1,4,5-Trideoxy-1,4-imino-5-(p-methoxyphenyl)-D-xylo-pentitol 3-acetate;   2-(p-Methoxybenzyl)-3,4-pyrrolidinediol 3-acetate;   2-p-Methoxyphenylmethyl-3-acetoxy-4-hydroxypyrrolidine;   Formula=C14H19NO4;   InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1;   InChIKey=YKJYKKNCCRKFSL-RDBSUJKOSA-N;   SMILES=COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(C)=O)cc1
 alt_id: CHEBI:2737;   CHEBI:40748
 xref: Beilstein:20705;   CAS:22862-76-6;   DrugBank:DB07374;   KEGG:C11281;   LINCS:LSM-4047
 xref_mesh: MESH:D000841
 xref: PDBeChem:ANM;   PMID:16005213;   PMID:22004851;   PMID:23192275;   PMID:23525555;   PMID:23582782;   PMID:24333448;   PMID:6834379;   Reaxys:20705;   Wikipedia:Anisomycin


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(-)-anisomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc3 ATP binding cassette subfamily C member 3 increases expression
multiple interactions
ISO Anisomycin results in increased expression of ABCC3 mRNA
SB 203580 inhibits the reaction [Anisomycin results in increased expression of ABCC3 mRNA]
CTD PMID:27507784 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Ago2 argonaute RISC catalytic component 2 increases phosphorylation ISO Anisomycin results in increased phosphorylation of AGO2 protein CTD PMID:18476811 NCBI chr 7:114,339,607...114,377,277
Ensembl chr 7:114,339,434...114,380,613
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions
decreases expression
ISO Anisomycin promotes the reaction [Tetrachlorodibenzodioxin results in increased degradation of and results in decreased expression of AHR protein]
Anisomycin results in decreased expression of AHR protein
CTD PMID:15385644 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Atf1 activating transcription factor 1 increases phosphorylation
multiple interactions
ISO Anisomycin results in increased phosphorylation of ATF1 protein
[SB 203580 co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] inhibits the reaction [Anisomycin results in increased phosphorylation of ATF1 protein]; SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of ATF1 protein]
CTD PMID:12660819 NCBI chr 7:141,882,261...141,924,790
Ensembl chr 7:141,882,251...141,924,788
JBrowse link
G Atf2 activating transcription factor 2 increases phosphorylation
multiple interactions
ISO Anisomycin results in increased phosphorylation of ATF2 protein
pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of ATF2 protein]; SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of ATF2 protein]
CTD PMID:12663670, PMID:28975372 NCBI chr 3:60,721,137...60,795,951
Ensembl chr 3:60,721,135...60,795,951
JBrowse link
G Atf3 activating transcription factor 3 multiple interactions
increases expression
ISO [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of ATF3 mRNA] CTD PMID:19101521, PMID:22003189 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atg13 autophagy related 13 decreases expression ISO Anisomycin results in decreased expression of ATG13 protein CTD PMID:27629431 NCBI chr 3:80,580,549...80,614,554
Ensembl chr 3:80,581,247...80,601,410
JBrowse link
G Atg4b autophagy related 4B, cysteine peptidase decreases expression ISO Anisomycin results in decreased expression of ATG4B protein CTD PMID:27629431 NCBI chr 9:100,888,457...100,920,123
Ensembl chr 9:100,888,501...100,918,637
JBrowse link
G Bach2 BTB domain and CNC homolog 2 increases expression ISO Anisomycin results in increased expression of BACH2 mRNA CTD PMID:24247028 NCBI chr 5:47,458,891...47,807,176
Ensembl chr 5:47,546,014...47,807,166
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP [Colistin co-treated with Anisomycin] results in increased phosphorylation of BCL2 protein CTD PMID:28842171 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Becn1 beclin 1 multiple interactions EXP Anisomycin promotes the reaction [Colistin results in increased expression of BECN1 protein] CTD PMID:28842171 NCBI chr10:89,209,944...89,225,297
Ensembl chr10:89,209,940...89,225,297
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO Anisomycin results in increased cleavage of and results in increased activity of BID protein CTD PMID:18241849 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Anisomycin promotes the reaction [(+)-JQ1 compound results in decreased expression of BIRC5 protein] CTD PMID:23872705 NCBI chr10:106,856,097...106,864,419
Ensembl chr10:106,856,097...106,864,413
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
ISO
EXP
Anisomycin promotes the reaction [Indomethacin results in increased activity of CASP3 protein]; Anisomycin results in increased cleavage of and results in increased activity of CASP3 protein
Anisomycin results in increased expression of CASP3 protein modified form
[Colistin co-treated with Anisomycin] results in increased cleavage of CASP3 protein
CTD PMID:17341418, PMID:18241849, PMID:28842171, PMID:29944914 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp6 caspase 6 multiple interactions ISO Anisomycin promotes the reaction [Indomethacin results in increased activity of CASP6 protein] CTD PMID:17341418 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967
JBrowse link
G Casp8 caspase 8 increases activity ISO Anisomycin results in increased activity of CASP8 protein CTD PMID:18241849 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 multiple interactions ISO Anisomycin promotes the reaction [Indomethacin results in increased activity of CASP9 protein] CTD PMID:17341418 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Cav1 caveolin 1 multiple interactions
increases phosphorylation
ISO wogonin inhibits the reaction [Anisomycin results in increased phosphorylation of CAV1 protein] CTD PMID:23246481 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression ISO Anisomycin results in decreased expression of CCL2 protein CTD PMID:20116850 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 decreases expression ISO Anisomycin results in decreased expression of CCL4 protein CTD PMID:20116850 NCBI chr10:70,870,926...70,886,357
Ensembl chr10:70,884,531...70,886,355
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 decreases expression ISO Anisomycin results in decreased expression of CCL5 protein CTD PMID:20116850 NCBI chr10:70,739,764...70,744,303
Ensembl chr10:70,739,800...70,744,315
JBrowse link
G Cd55 CD55 molecule (Cromer blood group) increases expression ISO Anisomycin results in increased expression of CD55 mRNA CTD PMID:24247028 NCBI chr13:47,125,156...47,153,557
Ensembl chr13:47,126,741...47,154,292
JBrowse link
G Cd69 Cd69 molecule increases expression ISO Anisomycin results in increased expression of CD69 mRNA CTD PMID:24247028 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases phosphorylation
multiple interactions
ISO Anisomycin results in increased phosphorylation of CREB1 protein
SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of CREB1 protein]
CTD PMID:12660819 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Crebbp CREB binding protein increases expression ISO Anisomycin results in increased expression of CREBBP mRNA CTD PMID:24247028 NCBI chr10:11,590,994...11,721,039
Ensembl chr10:11,595,044...11,721,039
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 multiple interactions
increases expression
ISO [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL1 mRNA] CTD PMID:22003189 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl3 C-X-C motif chemokine ligand 3 increases expression
multiple interactions
ISO Anisomycin results in increased expression of CXCL1 mRNA
[Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL1 mRNA]
CTD PMID:22003189 NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions
ISO Anisomycin results in increased expression of CYP1A1 mRNA
[Anisomycin co-treated with Tetrachlorodibenzodioxin] results in increased expression of CYP1A1 mRNA
CTD PMID:15385644 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 multiple interactions ISO Anisomycin inhibits the reaction [Tretinoin results in increased expression of CYP26A1 mRNA] CTD PMID:16038797 NCBI chr 1:256,382,861...256,386,729
Ensembl chr 1:256,382,791...256,386,729
JBrowse link
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 multiple interactions ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2A7 mRNA]; [Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2A7 mRNA CTD PMID:23539296 NCBI chr 1:83,653,248...83,662,118
Ensembl chr 1:83,653,234...83,766,484
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions ISO Anisomycin promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B6 mRNA] CTD PMID:23539296 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime co-treated with Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2B6 mRNA CTD PMID:23539296 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO Anisomycin results in increased expression of DDIT3 mRNA CTD PMID:18241849 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression ISO Anisomycin results in decreased expression of DUSP6 mRNA CTD PMID:24247028 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
JBrowse link
G Egr1 early growth response 1 multiple interactions
increases expression
ISO SB 203580 inhibits the reaction [Anisomycin results in increased expression of EGR1 mRNA] CTD PMID:9671412 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E increases phosphorylation
multiple interactions
ISO Anisomycin results in increased phosphorylation of EIF4E protein
SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of EIF4E protein]
CTD PMID:9545260 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Elk1 ETS transcription factor ELK1 increases phosphorylation
multiple interactions
ISO Anisomycin results in increased phosphorylation of ELK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Anisomycin results in increased phosphorylation of ELK1 protein]; pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of ELK1 protein]
CTD PMID:12660819 NCBI chr  X:1,287,875...1,304,822
Ensembl chr  X:1,297,099...1,304,822
JBrowse link
G Evi2a ecotropic viral integration site 2A increases expression ISO Anisomycin results in increased expression of EVI2A mRNA CTD PMID:24247028 NCBI chr10:66,870,048...66,873,948
Ensembl chr10:66,870,067...66,873,948
JBrowse link
G Fas Fas cell surface death receptor increases localization ISO Anisomycin results in increased localization of FAS protein CTD PMID:18241849 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Anisomycin results in increased expression of FOS mRNA CTD PMID:12660819, PMID:18241849 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Fosb FosB proto-oncogene, AP-1 transcription factor subunit increases expression ISO Anisomycin results in increased expression of FOSB mRNA CTD PMID:18241849 NCBI chr 1:80,214,691...80,221,417
Ensembl chr 1:80,214,494...80,221,710
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions ISO Anisomycin inhibits the reaction [GHRL protein inhibits the reaction [Uranium results in decreased expression of and results in decreased secretion of TNFRSF11B protein]]; Anisomycin inhibits the reaction [GHRL protein inhibits the reaction [Uranium results in increased expression of and results in increased secretion of TNFSF11 protein]] CTD PMID:29477364 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Hoxa1 homeobox A1 multiple interactions ISO Anisomycin promotes the reaction [Tretinoin results in increased expression of HOXA1 mRNA] CTD PMID:16038797 NCBI chr 4:82,124,358...82,127,182
Ensembl chr 4:82,125,406...82,127,066
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression ISO Anisomycin results in decreased expression of HSPA5 mRNA; Anisomycin results in decreased expression of HSPA5 protein CTD PMID:25324550 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 multiple interactions EXP Anisomycin inhibits the reaction [Cocaine results in increased expression of HSPA9 protein] CTD PMID:12422371 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Anisomycin inhibits the reaction [TNF protein results in increased expression of and affects the localization of ICAM1 protein] CTD PMID:21448188 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Anisomycin promotes the reaction [IGF1 protein results in increased phosphorylation of JUN protein] CTD PMID:11278392 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Il1b interleukin 1 beta increases expression ISO Anisomycin results in increased expression of IL1B protein CTD PMID:15019843 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6r interleukin 6 receptor decreases expression ISO Anisomycin results in decreased expression of IL6R protein modified form CTD PMID:20116850 NCBI chr 2:189,196,180...189,255,987
Ensembl chr 2:189,205,701...189,254,628
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases phosphorylation
increases expression
ISO
EXP
Anisomycin promotes the reaction [IGF1 protein results in increased phosphorylation of JUN protein]
Anisomycin results in increased phosphorylation of JUN protein
Anisomycin results in increased expression of JUN mRNA
CTD PMID:9751194, PMID:11278392, PMID:15019843, PMID:18241849, PMID:21815634 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression ISO Anisomycin results in increased expression of JUND mRNA CTD PMID:18241849 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Maff MAF bZIP transcription factor F increases expression ISO Anisomycin results in increased expression of MAFF mRNA CTD PMID:24247028 NCBI chr 7:120,580,743...120,592,095
Ensembl chr 7:120,580,743...120,592,095
JBrowse link
G Map3k20 mitogen-activated protein kinase kinase kinase 20 multiple interactions ISO MAP3K20 protein promotes the reaction [Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; quinoline analog inhibits the reaction [MAP3K20 protein promotes the reaction [Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein]] CTD PMID:15737997 NCBI chr 3:58,965,025...59,120,507
Ensembl chr 3:58,965,552...59,067,369
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases expression
increases phosphorylation
increases activity
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK1 protein]
Anisomycin results in increased expression of MAPK1 protein modified form
Anisomycin results in increased activity of MAPK1 protein
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK1 protein]; SB 203580 promotes the reaction [Anisomycin results in increased phosphorylation of MAPK1 protein]
CTD PMID:9671412, PMID:11551972, PMID:12660819, PMID:15772366, PMID:25233930 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions
increases activity
ISO Dicumarol inhibits the reaction [Anisomycin results in increased activity of MAPK10 protein] CTD PMID:10531305 NCBI chr14:8,079,955...8,371,508
Ensembl chr14:8,080,275...8,368,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions
increases phosphorylation
ISO
EXP
Anisomycin results in increased phosphorylation of and results in increased activity of MAPK14 protein
Anisomycin results in increased phosphorylation of MAPK14 protein
MAPK14 protein affects the reaction [Anisomycin results in increased activity of MAPKAPK2 protein]
CTD PMID:10704466, PMID:15961565, PMID:16038797, PMID:16364386 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
increases expression
increases phosphorylation
ISO
EXP
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK3 protein]
Anisomycin results in increased expression of MAPK3 protein modified form
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK3 protein]
CTD PMID:12660819, PMID:15772366, PMID:25233930 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
increases activity
multiple interactions
ISO
EXP
Anisomycin results in increased phosphorylation of MAPK8 protein
Anisomycin results in increased activity of MAPK8 protein
Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein; MAP3K20 protein promotes the reaction [Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein]; quinoline analog inhibits the reaction [MAP3K20 protein promotes the reaction [Anisomycin results in increased phosphorylation of and results in increased activity of MAPK8 protein]]
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK8 protein]
CTD PMID:12902192, PMID:12967334, PMID:15737997, PMID:15772366, PMID:15961565, PMID:16038797, PMID:18241849 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
ISO 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Anisomycin results in increased phosphorylation of MAPK9 protein] CTD PMID:12967334, PMID:15772366, PMID:16038797 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 increases activity
multiple interactions
ISO Anisomycin results in increased activity of MAPKAPK2 protein
MAPK14 protein affects the reaction [Anisomycin results in increased activity of MAPKAPK2 protein]
CTD PMID:10704466 NCBI chr13:47,785,157...47,871,684
Ensembl chr13:47,785,161...47,831,110
JBrowse link
G Mknk1 MAPK interacting serine/threonine kinase 1 increases activity
multiple interactions
ISO Anisomycin results in increased activity of MKNK1 protein
SB 203580 inhibits the reaction [Anisomycin results in increased activity of MKNK1 protein]
CTD PMID:9545260 NCBI chr 5:134,691,852...134,730,887
Ensembl chr 5:134,691,881...134,730,893
JBrowse link
G Mrps30 mitochondrial ribosomal protein S30 increases expression ISO Anisomycin results in increased expression of MRPS30 mRNA CTD PMID:24247028 NCBI chr 2:51,042,548...51,049,423
Ensembl chr 2:51,042,546...51,049,449
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Anisomycin results in increased expression of MYC mRNA CTD PMID:24247028 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 multiple interactions ISO [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of ATF3 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL1 mRNA]; [Acetylmuramyl-Alanyl-Isoglutamine binds to and results in increased activity of NOD2 protein] promotes the reaction [Anisomycin results in increased expression of CXCL8 mRNA] CTD PMID:22003189 NCBI chr19:19,342,061...19,389,366
Ensembl chr19:19,332,594...19,377,492
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions ISO 1,4-bis(2-(3,5-dichloropyridyloxy))benzene promotes the reaction [[Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2A7 mRNA]; [Anisomycin co-treated with 1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2C9 mRNA; [Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2A7 mRNA; Anisomycin promotes the reaction [[1,4-bis(2-(3,5-dichloropyridyloxy))benzene co-treated with NR1I3 protein] results in increased expression of CYP2B6 mRNA]
[6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime co-treated with Anisomycin co-treated with NR1I3 protein] results in increased expression of CYP2B6 mRNA
CTD PMID:23539296 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP [Colistin co-treated with Anisomycin] results in increased cleavage of PARP1 protein CTD PMID:28842171 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression ISO Anisomycin results in increased expression of PMAIP1 mRNA CTD PMID:24247028 NCBI chr18:62,159,128...62,179,635
Ensembl chr18:62,174,670...62,181,102
JBrowse link
G Postn periostin increases expression EXP Anisomycin results in increased expression of POSTN mRNA CTD PMID:15121739 NCBI chr 2:143,656,820...143,688,087
Ensembl chr 2:143,656,793...143,688,087
JBrowse link
G Ptpn5 protein tyrosine phosphatase, non-receptor type 5 multiple interactions EXP Anisomycin inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein] CTD PMID:17623046 NCBI chr 1:103,197,918...103,258,309
Ensembl chr 1:103,197,915...103,256,823
JBrowse link
G Rarb retinoic acid receptor, beta multiple interactions ISO Anisomycin promotes the reaction [Tretinoin results in increased expression of RARB mRNA] CTD PMID:16038797 NCBI chr15:9,915,223...10,262,599
Ensembl chr15:10,120,206...10,262,599
JBrowse link
G Ret ret proto-oncogene decreases expression EXP Anisomycin results in decreased expression of RET protein CTD PMID:17555550 NCBI chr 4:150,202,170...150,249,196
Ensembl chr 4:150,202,058...150,244,372
JBrowse link
G Rhoh ras homolog family member H increases expression ISO Anisomycin results in increased expression of RHOH mRNA CTD PMID:24247028 NCBI chr14:43,961,756...43,992,587
Ensembl chr14:43,961,756...43,992,587
JBrowse link
G Rora RAR-related orphan receptor A increases expression ISO Anisomycin results in increased expression of RORA mRNA CTD PMID:24247028 NCBI chr 8:75,515,886...75,616,477
Ensembl chr 8:75,516,904...75,607,212
JBrowse link
G Rxra retinoid X receptor alpha increases phosphorylation
multiple interactions
ISO Anisomycin results in increased phosphorylation of RXRA protein
pyrazolanthrone inhibits the reaction [Anisomycin results in increased phosphorylation of RXRA protein]
CTD PMID:16038797, PMID:16184197 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP Anisomycin promotes the reaction [Colistin results in increased degradation of SQSTM1 protein] CTD PMID:28842171 NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
JBrowse link
G Srf serum response factor increases phosphorylation
multiple interactions
ISO Anisomycin results in increased phosphorylation of SRF protein
SB 203580 inhibits the reaction [Anisomycin results in increased phosphorylation of SRF protein]
CTD PMID:12660819 NCBI chr 9:16,737,637...16,747,226
Ensembl chr 9:16,737,642...16,747,225
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO Anisomycin promotes the reaction [8-Bromo Cyclic Adenosine Monophosphate results in increased expression of STAR mRNA]; Anisomycin results in increased expression of and results in increased stability of STAR mRNA CTD PMID:15713539 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions
ISO Anisomycin results in increased expression of TNF mRNA
Anisomycin inhibits the reaction [TNF protein results in increased expression of and affects the localization of ICAM1 protein]
CTD PMID:18241849, PMID:21448188 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnfrsf11b TNF receptor superfamily member 11B multiple interactions ISO Anisomycin inhibits the reaction [GHRL protein inhibits the reaction [Uranium results in decreased expression of and results in decreased secretion of TNFRSF11B protein]] CTD PMID:29477364 NCBI chr 7:93,798,580...93,826,586
Ensembl chr 7:93,798,545...93,826,665
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO Anisomycin inhibits the reaction [GHRL protein inhibits the reaction [Uranium results in increased expression of and results in increased secretion of TNFSF11 protein]] CTD PMID:29477364 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link
G Tnfsf9 TNF superfamily member 9 increases expression
decreases expression
ISO Anisomycin results in increased expression of TNFSF9 mRNA
Anisomycin results in decreased expression of TNFSF9 mRNA
CTD PMID:18241849, PMID:24247028 NCBI chr 9:9,909,942...9,912,276
Ensembl chr 9:9,909,948...9,912,276
JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Anisomycin promotes the reaction [Colistin results in increased expression of TP53 protein] CTD PMID:28842171 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Txnip thioredoxin interacting protein increases expression ISO Anisomycin results in increased expression of TXNIP mRNA CTD PMID:10843682 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
JBrowse link
G Ulk1 unc-51 like autophagy activating kinase 1 decreases expression ISO Anisomycin results in decreased expression of ULK1 protein CTD PMID:27629431 NCBI chr12:51,908,105...51,934,704
Ensembl chr12:51,908,448...51,934,702
JBrowse link
G Usp30 ubiquitin specific peptidase 30 increases expression ISO Anisomycin results in increased expression of USP30 mRNA CTD PMID:24247028 NCBI chr12:48,262,663...48,316,580
Ensembl chr12:48,262,658...48,316,722
JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO Anisomycin results in decreased expression of VEGFA protein CTD PMID:20116850 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
JBrowse link
G Xbp1 X-box binding protein 1 decreases splicing ISO Anisomycin results in decreased splicing of XBP1 mRNA CTD PMID:25324550 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      biological role 19732
        antimicrobial agent 17309
          (-)-anisomycin 87
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  organic heteromonocyclic compound 16444
                                    pyrrolidines 2223
                                      hydroxypyrrolidine 87
                                        monohydroxypyrrolidine 87
                                          (-)-anisomycin 87
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.