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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:macromolecule
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Accession:CHEBI:33839 term browser browse the term
Definition:A macromolecule is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass.
Synonyms:related_synonym: macromolecules;   polymer;   polymer molecule;   polymers
 xref: Wikipedia:Macromolecule


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chondroitin sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF10 fibroblast growth factor 10 affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein CTD PMID:14699094 NCBI chr16:28,695,465...28,779,953
Ensembl chr16:28,695,469...28,777,541
JBrowse link
G FGF18 fibroblast growth factor 18 affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein CTD PMID:14699094 NCBI chr16:52,724,867...52,760,246
Ensembl chr16:52,725,356...52,760,236
JBrowse link
G FGF2 fibroblast growth factor 2 affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF2 protein CTD PMID:14699094 NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,878...101,343,916
JBrowse link
G MDK midkine affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein CTD PMID:14699094 NCBI chr 2:16,130,787...16,133,791
Ensembl chr 2:16,130,782...16,133,510
JBrowse link
G PTN pleiotrophin affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to PTN protein CTD PMID:14699094 NCBI chr18:12,219,708...12,309,045
Ensembl chr18:12,219,790...12,311,922
JBrowse link
dermatan sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF10 fibroblast growth factor 10 affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein CTD PMID:14699094 NCBI chr16:28,695,465...28,779,953
Ensembl chr16:28,695,469...28,777,541
JBrowse link
G FGF18 fibroblast growth factor 18 affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein CTD PMID:14699094 NCBI chr16:52,724,867...52,760,246
Ensembl chr16:52,725,356...52,760,236
JBrowse link
G FGF2 fibroblast growth factor 2 affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF2 protein CTD PMID:14699094 NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,878...101,343,916
JBrowse link
G MDK midkine affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein CTD PMID:14699094 NCBI chr 2:16,130,787...16,133,791
Ensembl chr 2:16,130,782...16,133,510
JBrowse link
G PTN pleiotrophin affects binding EXP [Chondroitin Sulfates binds to Dermatan Sulfate] which binds to PTN protein CTD PMID:14699094 NCBI chr18:12,219,708...12,309,045
Ensembl chr18:12,219,790...12,311,922
JBrowse link
dextran sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP1 caspase 1, apoptosis-related cysteine peptidase multiple interactions
increases expression
EXP [Dextran Sulfate co-treated with Zearalenone] results in increased expression of CASP1 mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased expression of CASP1 protein; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of CASP1 mRNA]
Dextran Sulfate results in increased expression of CASP1 mRNA; Dextran Sulfate results in increased expression of CASP1 protein
CTD PMID:30270565 NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328
JBrowse link
G IL18 interleukin 18 increases expression
multiple interactions
EXP Dextran Sulfate results in increased expression of IL18 mRNA
[Dextran Sulfate co-treated with Zearalenone] results in increased expression of IL18 mRNA; Dextran Sulfate inhibits the reaction [Zearalenone results in increased expression of IL18 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of IL18 mRNA]
CTD PMID:30270565 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,966...39,873,300
JBrowse link
G LOC100522011 apoptosis-associated speck-like protein containing a CARD multiple interactions
increases expression
EXP [Dextran Sulfate co-treated with Zearalenone] results in increased expression of PYCARD mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased expression of PYCARD protein
Dextran Sulfate results in increased expression of PYCARD mRNA; Dextran Sulfate results in increased expression of PYCARD protein
CTD PMID:30270565 NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,179...17,307,512
JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions
increases expression
EXP [Dextran Sulfate co-treated with Zearalenone] results in increased expression of IL1B mRNA; Dextran Sulfate inhibits the reaction [Zearalenone results in increased expression of IL1B mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of IL1B mRNA] CTD PMID:30270565
G NLRP3 NLR family pyrin domain containing 3 multiple interactions
increases expression
EXP [Dextran Sulfate co-treated with Zearalenone] results in increased expression of NLRP3 mRNA; [Dextran Sulfate co-treated with Zearalenone] results in increased expression of NLRP3 protein; Dextran Sulfate inhibits the reaction [Zearalenone results in increased expression of NLRP3 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 mRNA]; Zearalenone inhibits the reaction [Dextran Sulfate results in increased expression of NLRP3 protein]
Dextran Sulfate results in increased expression of NLRP3 mRNA; Dextran Sulfate results in increased expression of NLRP3 protein
CTD PMID:30270565 NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,242...56,977,234
JBrowse link
fucoidan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNF tumor necrosis factor multiple interactions EXP [laminaran co-treated with fucoidan co-treated with Minerals] promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:21948611 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
heparin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PSP-I porcine seminal protein I multiple interactions EXP zinc chloride promotes the reaction [PSP-I protein binds to Heparin]; Zinc promotes the reaction [PSP-I protein binds to Heparin] CTD PMID:16819821 NCBI chr14:132,302,376...132,309,388
Ensembl chr14:132,274,241...132,320,855
JBrowse link
hyaluronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EGFR epidermal growth factor receptor multiple interactions EXP EGFR protein affects the chemical synthesis of and affects the localization of Hyaluronic Acid CTD PMID:21520325 NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,478,882
JBrowse link
laminarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNF tumor necrosis factor multiple interactions EXP [laminaran co-treated with fucoidan co-treated with Minerals] promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:21948611 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
lipopolysaccharide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP [Flavones co-treated with Lipopolysaccharides] results in increased phosphorylation of AKT1 protein CTD PMID:31669396
G ALB albumin decreases expression EXP Lipopolysaccharides results in decreased expression of ALB protein CTD PMID:19477247 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,718,304
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP Lipopolysaccharides results in increased expression of BAX protein
Flavones inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]
CTD PMID:31669396 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression EXP Lipopolysaccharides results in increased expression of BCL2 mRNA CTD PMID:21645290 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G CASP3 caspase 3 increases expression
multiple interactions
EXP Lipopolysaccharides results in increased expression of CASP3 protein
Flavones inhibits the reaction [Lipopolysaccharides results in increased expression of CASP3 protein]
CTD PMID:31669396 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CASP6 caspase 6 decreases expression EXP Lipopolysaccharides results in decreased expression of CASP6 mRNA CTD PMID:21645290 NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,483,392...112,540,550
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP [deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA] CTD PMID:30708112 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CCL20 C-C motif chemokine ligand 20 multiple interactions EXP [deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA] CTD PMID:30708112 NCBI chr15:129,172,743...129,176,069 JBrowse link
G CFLAR CASP8 and FADD like apoptosis regulator decreases expression EXP Lipopolysaccharides results in decreased expression of CFLAR mRNA CTD PMID:21645290 NCBI chr15:104,780,744...104,835,631
Ensembl chr15:104,781,615...104,844,921
JBrowse link
G CLDN1 claudin 1 decreases expression EXP Lipopolysaccharides results in decreased expression of CLDN1 protein CTD PMID:22092031 NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,767...127,730,657
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases secretion
multiple interactions
increases expression
EXP Lipopolysaccharides results in increased secretion of CXCL8 protein
3',4',5'-trimethoxyflavone analog inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; [deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CXCL8 mRNA; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CXCL8 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA]; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CXCL8 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CXCL8 mRNA]; Lipopolysaccharides results in increased expression of and results in increased secretion of CXCL8 protein
CTD PMID:15912099, PMID:26180592, PMID:27861533, PMID:30708112 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G DIABLO diablo IAP-binding mitochondrial protein decreases expression EXP Lipopolysaccharides results in decreased expression of DIABLO mRNA CTD PMID:21645290 NCBI chr14:30,498,885...30,519,846
Ensembl chr14:30,498,900...30,520,071
JBrowse link
G GRHPR glyoxylate and hydroxypyruvate reductase affects expression EXP Lipopolysaccharides affects the expression of GRHPR mRNA CTD PMID:21645290 NCBI chr 1:238,139,764...238,151,631
Ensembl chr 1:238,139,789...238,153,071
JBrowse link
G IFNG interferon gamma increases expression EXP Lipopolysaccharides results in increased expression of IFNG mRNA CTD PMID:15998543 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
G IL10 interleukin 10 increases expression EXP Lipopolysaccharides results in increased expression of IL10 mRNA CTD PMID:15998543 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,727...67,405,711
JBrowse link
G IL12A interleukin 12A increases expression EXP Lipopolysaccharides results in increased expression of IL12A mRNA CTD PMID:15998543 NCBI chr13:99,733,394...99,741,078
Ensembl chr13:99,733,394...99,741,078
JBrowse link
G IL13 interleukin 13 increases expression EXP Lipopolysaccharides results in increased expression of IL13 mRNA CTD PMID:15998543 NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093
JBrowse link
G IL17A interleukin 17A multiple interactions EXP [deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of IL17A protein; fumonisin B1 inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of IL17A protein]; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of IL17A protein] CTD PMID:30708112 NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153
JBrowse link
G IL1A interleukin 1 alpha multiple interactions
increases expression
EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]] CTD PMID:28528741 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119
JBrowse link
G IL6 interleukin 6 increases secretion
increases expression
multiple interactions
EXP Lipopolysaccharides results in increased secretion of IL6 protein
Lipopolysaccharides results in increased expression of IL6 mRNA
Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein; picolinic acid promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]
CTD PMID:8724211, PMID:26180592, PMID:27861533 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G INS insulin decreases expression
multiple interactions
EXP Lipopolysaccharides results in decreased expression of INS protein
GH1 protein inhibits the reaction [Lipopolysaccharides results in decreased expression of INS protein]
CTD PMID:9185964 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
EXP Lipopolysaccharides results in increased phosphorylation of MAPK1 protein
ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD PMID:28528741 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:28528741 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member decreases expression EXP Lipopolysaccharides results in decreased expression of MCL1 mRNA CTD PMID:21645290 NCBI chr 4:98,562,092...98,567,014
Ensembl chr 4:98,527,907...98,567,006
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor increases expression
multiple interactions
EXP Lipopolysaccharides results in increased expression of MYD88 mRNA; Lipopolysaccharides results in increased expression of MYD88 protein
ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]
CTD PMID:28528741 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,964,071...22,983,109
JBrowse link
G NCF1 neutrophil cytosolic factor 1 decreases expression EXP Lipopolysaccharides results in decreased expression of NCF1 mRNA CTD PMID:21645290 NCBI chr 3:11,820,367...11,834,394
Ensembl chr 3:11,820,285...11,839,426
JBrowse link
G NCF2 neutrophil cytosolic factor 2 decreases expression EXP Lipopolysaccharides results in decreased expression of NCF2 mRNA CTD PMID:21645290 NCBI chr 9:124,776,516...124,813,358
Ensembl chr 9:124,773,498...124,812,928
JBrowse link
G NCF4 neutrophil cytosolic factor 4 decreases expression EXP Lipopolysaccharides results in decreased expression of NCF4 mRNA CTD PMID:21645290 NCBI chr 5:10,876,147...10,994,002
Ensembl chr 5:10,874,953...10,994,015
JBrowse link
G NOS2 nitric oxide synthase 2 affects expression EXP Lipopolysaccharides affects the expression of NOS2 mRNA; Lipopolysaccharides affects the expression of NOS2 protein CTD PMID:12893242 NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,944...44,327,111
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions
EXP Lipopolysaccharides results in increased expression of PTGS2 mRNA
3',4',5'-trimethoxyflavone analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
CTD PMID:26180592, PMID:27861533 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit increases phosphorylation
multiple interactions
EXP Lipopolysaccharides results in increased phosphorylation of RELA protein
[Flavones co-treated with Lipopolysaccharides] results in increased phosphorylation of RELA protein; ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
CTD PMID:28528741, PMID:31669396 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 decreases expression EXP Lipopolysaccharides results in decreased expression of ROCK1 mRNA CTD PMID:21645290 NCBI chr 6:106,163,899...106,314,998
Ensembl chr 6:106,163,903...106,314,944
JBrowse link
G SELE selectin E increases expression EXP Lipopolysaccharides results in increased expression of SELE CTD PMID:12224865 NCBI chr 4:81,289,061...81,299,657 JBrowse link
G SIRPA signal regulatory protein alpha affects expression EXP Lipopolysaccharides affects the expression of SIRPA mRNA CTD PMID:21645290 NCBI chr17:33,566,270...33,611,375 JBrowse link
G SLC38A1 solute carrier family 38 member 1 affects expression EXP Lipopolysaccharides affects the expression of SLC38A1 mRNA CTD PMID:21645290 NCBI chr 5:77,009,840...77,076,723 JBrowse link
G SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 affects expression EXP Lipopolysaccharides affects the expression of SMARCA4 mRNA CTD PMID:21645290 NCBI chr 2:69,717,175...69,810,301
Ensembl chr 2:69,662,238...69,810,298
JBrowse link
G TLR4 toll like receptor 4 multiple interactions
increases expression
EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
Lipopolysaccharides results in increased expression of TLR4 mRNA; Lipopolysaccharides results in increased expression of TLR4 protein
CTD PMID:15998543, PMID:28528741 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,059,004
JBrowse link
G TNF tumor necrosis factor increases expression
increases secretion
multiple interactions
EXP Lipopolysaccharides results in increased expression of TNF mRNA; Lipopolysaccharides results in increased expression of TNF protein
Lipopolysaccharides results in increased secretion of TNF protein
3',4',5'-trimethoxyflavone analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; [deoxynivalenol co-treated with Lipopolysaccharides co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with Lipopolysaccharides co-treated with fumonisin B1] results in increased expression of TNF protein; [laminaran co-treated with fucoidan co-treated with Minerals] promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; GH1 protein inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; picolinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
CTD PMID:9185964, PMID:12406900, PMID:21948611, PMID:26180592, PMID:27861533, PMID:28528741, PMID:30708112 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
lipoteichoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IFNG interferon gamma increases expression EXP lipoteichoic acid results in increased expression of IFNG mRNA CTD PMID:15998543 NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,848...32,482,752
JBrowse link
G IL10 interleukin 10 increases expression EXP lipoteichoic acid results in increased expression of IL10 mRNA CTD PMID:15998543 NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,727...67,405,711
JBrowse link
G IL12A interleukin 12A increases expression EXP lipoteichoic acid results in increased expression of IL12A mRNA CTD PMID:15998543 NCBI chr13:99,733,394...99,741,078
Ensembl chr13:99,733,394...99,741,078
JBrowse link
G IL13 interleukin 13 increases expression EXP lipoteichoic acid results in increased expression of IL13 mRNA CTD PMID:15998543 NCBI chr 2:134,972,099...134,976,672
Ensembl chr 2:134,972,623...134,975,093
JBrowse link
G TLR4 toll like receptor 4 increases expression EXP lipoteichoic acid results in increased expression of TLR4 mRNA CTD PMID:15998543 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,059,004
JBrowse link
mastoparan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SELE selectin E increases expression EXP mastoparan results in increased expression of SELE mRNA CTD PMID:10769290 NCBI chr 4:81,289,061...81,299,657 JBrowse link
melittin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL4 interleukin 4 decreases response to substance EXP IL4 protein results in decreased susceptibility to Melitten CTD PMID:20017192 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365
JBrowse link
G PLA2G1B phospholipase A2 group IB increases activity EXP Melitten results in increased activity of PLA2G1B protein CTD PMID:9092818 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,444...40,322,319
JBrowse link
G SELE selectin E increases expression EXP Melitten results in increased expression of SELE mRNA CTD PMID:10769290 NCBI chr 4:81,289,061...81,299,657 JBrowse link
omega-conotoxin GVIA term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 multiple interactions EXP omega-Conotoxin GVIA inhibits the reaction [ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] CTD PMID:14662737 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,630...105,422,295
JBrowse link
G OPRM1 opioid receptor mu 1 multiple interactions EXP omega-Conotoxin GVIA inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]] CTD PMID:12031848 NCBI chr 1:12,634,125...12,702,295
Ensembl chr 1:12,528,672...12,702,443
JBrowse link
G VIP vasoactive intestinal peptide multiple interactions EXP omega-Conotoxin GVIA inhibits the reaction [VIP protein results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid] CTD PMID:14662737 NCBI chr 1:13,611,786...13,620,250
Ensembl chr 1:13,611,311...13,620,269
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 876
    chemical entity 876
      molecular entity 874
        polyatomic entity 839
          macromolecule 55
            10-formyltetrahydrofolyl polyglutamate macromolecule + 0
            5-methyltetrahydrofolyl polyglutamate macromolecule + 0
            acrylic macromolecule + 0
            atactic macromolecule + 0
            biomacromolecule + 50
            conjugated macromolecule + 0
            copolymer macromolecule + 0
            dendrimer macromolecule + 0
            glycopolymer macromolecule + 0
            graft polymer macromolecule + 0
            heteropolyacid macromolecule + 0
            homopolymer macromolecule + 0
            hyperbranched macromolecule + 0
            ionic macromolecule + 0
            ionomer macromolecule + 0
            isotactic macromolecule + 0
            molecular knot + 0
            poly(amide) macromolecule + 0
            poly(aryleneethynylene) macromolecule + 0
            poly(ether) macromolecule + 0
            poly(melamine) macromolecule + 0
            poly(silane) macromolecules + 0
            poly(sulfide) macromolecule + 0
            polyamine macromolecule + 0
            polyaniline macromolecule + 0
            polyanionic macromolecule + 0
            polyarylene macromolecule + 0
            polycarbonate macromolecule + 0
            polyester macromolecule + 0
            polyimide macromolecule + 0
            polymer + 0
            polypeptide + 6
            polysiloxane macromolecule + 0
            polysilsesquioxane macromolecule + 0
            propineb 0
            syndiotactic macromolecule + 0
            tactic macromolecule + 0
            telechelic polymer 0
            zineb + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 876
    subatomic particle 861
      composite particle 861
        hadron 861
          baryon 861
            nucleon 861
              atomic nucleus 861
                atom 861
                  group 839
                    polyatomic entity 839
                      macromolecule 55
                        10-formyltetrahydrofolyl polyglutamate macromolecule + 0
                        5-methyltetrahydrofolyl polyglutamate macromolecule + 0
                        acrylic macromolecule + 0
                        atactic macromolecule + 0
                        biomacromolecule + 50
                        conjugated macromolecule + 0
                        copolymer macromolecule + 0
                        dendrimer macromolecule + 0
                        glycopolymer macromolecule + 0
                        graft polymer macromolecule + 0
                        heteropolyacid macromolecule + 0
                        homopolymer macromolecule + 0
                        hyperbranched macromolecule + 0
                        ionic macromolecule + 0
                        ionomer macromolecule + 0
                        isotactic macromolecule + 0
                        molecular knot + 0
                        poly(amide) macromolecule + 0
                        poly(aryleneethynylene) macromolecule + 0
                        poly(ether) macromolecule + 0
                        poly(melamine) macromolecule + 0
                        poly(silane) macromolecules + 0
                        poly(sulfide) macromolecule + 0
                        polyamine macromolecule + 0
                        polyaniline macromolecule + 0
                        polyanionic macromolecule + 0
                        polyarylene macromolecule + 0
                        polycarbonate macromolecule + 0
                        polyester macromolecule + 0
                        polyimide macromolecule + 0
                        polymer + 0
                        polypeptide + 6
                        polysiloxane macromolecule + 0
                        polysilsesquioxane macromolecule + 0
                        propineb 0
                        syndiotactic macromolecule + 0
                        tactic macromolecule + 0
                        telechelic polymer 0
                        zineb + 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.