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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:captopril
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Accession:CHEBI:3380 term browser browse the term
Definition:A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug.
Synonyms:exact_synonym: 1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
 related_synonym: (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid;   Acepress;   Apopril;   CP;   Capoten;   Captolane;   Captopryl;   Captoril;   Cesplon;   D-2-methyl-3-mercaptopropanoyl-L-proline;   D-3-mercapto-2-methylpropanoyl-L-proline;   Dilabar;   Formula=C9H15NO3S;   Garranil;   Hypertil;   InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1;   InChIKey=FAKRSMQSSFJEIM-RQJHMYQMSA-N;   L-Captopril;   Lopirin;   SMILES=C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O;   Tenosbon;   Tensobon;   Tensoprel;   captoprilum
 xref: Beilstein:477887;   CAS:62571-86-2;   DrugBank:DB01197;   Drug_Central:484;   KEGG:D00251;   LINCS:LSM-5648
 xref_mesh: MESH:D002216
 xref: PMID:23137627;   PMID:23161035;   PMID:23278692;   PMID:23299024;   PMID:23328620;   PMID:23397376;   PMID:23410042;   PMID:23422724;   PMID:23429803;   PMID:23435971;   PMID:2420897;   Patent:US4046889;   Patent:US4105776;   Wikipedia:Captopril


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captopril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme multiple interactions
decreases activity		 EXP
ISO		 Captopril inhibits the reaction [Pregabalin results in increased expression of ACE protein]
Captopril results in decreased activity of ACE protein
Captopril inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACE mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACE protein]		 CTD PMID:26851370 PMID:31629013 PMID:33007385 NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131 		JBrowse link
G Ace2 angiotensin converting enzyme 2 decreases response to substance
multiple interactions		 ISO
EXP		 ACE2 gene SNP results in decreased susceptibility to Captopril
Captopril inhibits the reaction [Pregabalin results in decreased expression of ACE2 protein]
Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of ACE2 protein]		 CTD PMID:17473847 PMID:31629013 PMID:33007385 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]
Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of ACTA2 protein]		 CTD PMID:31181250 PMID:33007385 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Agt angiotensinogen multiple interactions EXP
ISO		 [icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of AGT protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of AGT protein]; Captopril inhibits the reaction [Pregabalin results in decreased expression of AGT protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]; [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [Cadmium Chloride results in increased expression of AGT protein]
Captopril inhibits the reaction [AGT protein results in decreased abundance of angiotensin I (1-7)]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 mRNA]; Captopril inhibits the reaction [AGT protein results in decreased expression of ACE2 protein]; Captopril inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Captopril inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE mRNA]; Captopril inhibits the reaction [AGT protein results in increased expression of ACE protein]; Captopril inhibits the reaction [AGT protein results in increased expression of ACTA2 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of AGT protein]; Captopril inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Captopril inhibits the reaction [AGT protein results in increased expression of VIM protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGT protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of AGT protein alternative form]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of AGT protein]		 CTD PMID:28130181 PMID:31181250 PMID:31629013 PMID:33007385 PMID:35844137 More... NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP
ISO		 Captopril inhibits the reaction [Pregabalin results in increased expression of AGTR1 protein]
Captopril inhibits the reaction [AGT protein results in increased expression of AGTR1 protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGTR1A mRNA]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of AGTR1 protein]		 CTD PMID:28130181 PMID:31629013 PMID:33007385 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO Captopril inhibits the reaction [Glucose results in increased expression of AKT1 mRNA] CTD PMID:38115276 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions EXP Captopril inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of ALPL protein] CTD PMID:27269004 NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446 		JBrowse link
G Bdkrb2 bradykinin receptor B2 multiple interactions ISO Captopril inhibits the reaction [LEPR protein affects the expression of BDKRB2 protein] CTD PMID:28130181 NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497 		JBrowse link
G Calb1 calbindin 1 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of CALB1 protein] CTD PMID:28130181 NCBI chr 5:29,375,624...29,402,532
Ensembl chr 5:29,375,642...29,402,431 		JBrowse link
G Car2 carbonic anhydrase 2 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of CAR2 mRNA] CTD PMID:28130181 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 Captopril inhibits the reaction [Methotrexate results in increased expression of CASP3 protein]
Captopril inhibits the reaction [Glucose results in increased expression of CASP3 mRNA]		 CTD PMID:27269004 PMID:38115276 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO Captopril inhibits the reaction [AGT protein results in decreased expression of CDH1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of CDH1 protein] CTD PMID:33007385 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Captopril inhibits the reaction [AGT protein results in increased expression of COL3A1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of COL3A1 protein] CTD PMID:33007385 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions EXP
ISO		 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI1 protein]		 CTD PMID:31181250 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Gli2 GLI family zinc finger 2 multiple interactions EXP
ISO		 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of GLI2 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of GLI2 protein]		 CTD PMID:31181250 NCBI chr13:29,946,882...30,163,589
Ensembl chr13:29,946,809...30,163,574 		JBrowse link
G Gli3 GLI family zinc finger 3 multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of GLI3 protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of GLI3 protein]		 CTD PMID:31181250 NCBI chr17:49,438,567...49,709,712
Ensembl chr17:49,438,567...49,709,712 		JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 multiple interactions EXP Captopril inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of GOT1 protein] CTD PMID:27269004 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP Captopril inhibits the reaction [Methotrexate results in increased expression of and results in increased secretion of GPT protein] CTD PMID:27269004 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 [icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of IL6 protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of IL6 protein]
Captopril inhibits the reaction [Glucose results in increased expression of IL6 mRNA]		 CTD PMID:38027817 PMID:38115276 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Kng1 kininogen 1 multiple interactions EXP [icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of KNG1 protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of KNG1 protein] CTD PMID:38027817 NCBI chr11:77,812,757...77,835,555
Ensembl chr11:77,812,752...77,835,555 		JBrowse link
G Lepr leptin receptor multiple interactions
affects response to substance		 ISO Captopril inhibits the reaction [LEPR protein affects the expression of AGT protein]; Captopril inhibits the reaction [LEPR protein affects the expression of AGTR1A mRNA]; Captopril inhibits the reaction [LEPR protein affects the expression of BDKRB2 protein]; Captopril inhibits the reaction [LEPR protein affects the expression of PTH protein]; Captopril inhibits the reaction [LEPR protein affects the expression of VEGFA mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of CALB1 protein]; Captopril promotes the reaction [LEPR protein affects the expression of CAR2 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of MMP9 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of RUNX2 mRNA]; Captopril promotes the reaction [LEPR protein affects the expression of VDR protein]
LEPR protein affects the susceptibility to Captopril		 CTD PMID:28130181 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908 		JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor multiple interactions EXP
ISO		 Captopril inhibits the reaction [Pregabalin results in decreased expression of MAS1 protein]
Captopril inhibits the reaction [AGT protein results in decreased expression of MAS1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of MAS1 protein]		 CTD PMID:31629013 PMID:33007385 NCBI chr 1:47,879,956...47,911,500
Ensembl chr 1:47,880,309...47,911,709 		JBrowse link
G Mir146a microRNA 146a multiple interactions EXP captopril inhibits the reaction [ischemia-reperfusion injury increases expression of Mir146a miRNA in kidney] RGD PMID:27760486 RGD:155882556 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mir320a microRNA 320a multiple interactions EXP captopril inhibits the reaction [ischemia-reperfusion injury increases expression of Mir320a miRNA in kidney] RGD PMID:27760486 RGD:155882556 NCBI chr15:45,516,392...45,516,473
Ensembl chr15:45,516,392...45,516,473 		JBrowse link
G Mlkl mixed lineage kinase domain like pseudokinase multiple interactions ISO Captopril inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MLKL protein] CTD PMID:35844137 NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of MMP9 mRNA] CTD PMID:28130181 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Captopril inhibits the reaction [Methotrexate results in increased expression of NOS2 protein] CTD PMID:27269004 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nppb natriuretic peptide B multiple interactions EXP Captopril inhibits the reaction [Pregabalin results in increased expression of NPPB protein] CTD PMID:31629013 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Prkaca protein kinase cAMP-activated catalytic subunit alpha multiple interactions EXP Captopril inhibits the reaction [Pregabalin results in decreased expression of PRKACA protein] CTD PMID:31629013 NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430 		JBrowse link
G Ptch1 patched 1 multiple interactions EXP
ISO		 [goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]; Captopril inhibits the reaction [Silicon Dioxide results in decreased expression of PTCH1 protein]
[goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in decreased expression of PTCH1 protein]		 CTD PMID:31181250 NCBI chr17:1,542,705...1,607,730
Ensembl chr17:1,542,877...1,607,333 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO		 Captopril inhibits the reaction [Methotrexate results in increased expression of PTGS2 protein]
Captopril inhibits the reaction [Glucose results in increased expression of PTGS2 mRNA]		 CTD PMID:27269004 PMID:38115276 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Pth parathyroid hormone multiple interactions ISO Captopril inhibits the reaction [LEPR protein affects the expression of PTH protein] CTD PMID:28130181 NCBI chr 1:167,508,121...167,511,530
Ensembl chr 1:167,508,598...167,511,530 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Captopril inhibits the reaction [Glucose results in increased phosphorylation of and results in increased localization of RELA protein] CTD PMID:38115276 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO Captopril inhibits the reaction [Cadmium Chloride results in increased expression of RIPK3 protein] CTD PMID:35844137 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of RUNX2 mRNA] CTD PMID:28130181 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167 		JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SHH protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SHH protein]		 CTD PMID:31181250 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Smo smoothened, frizzled class receptor multiple interactions ISO
EXP		 [goralatide co-treated with Captopril] inhibits the reaction [AGT protein results in increased expression of SMO protein]
[goralatide co-treated with Captopril] inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of SMO protein]		 CTD PMID:31181250 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP Captopril inhibits the reaction [Methotrexate results in decreased expression of and results in decreased activity of SOD1 protein] CTD PMID:27269004 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP [icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of TGFB1 protein] CTD PMID:38027817 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 [icatibant co-treated with Captopril] inhibits the reaction [bisphenol A results in increased expression of TNF protein]; Captopril inhibits the reaction [bisphenol A results in increased expression of TNF protein]
Captopril inhibits the reaction [Glucose results in increased expression of TNF mRNA]		 CTD PMID:38027817 PMID:38115276 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Captopril inhibits the reaction [Glucose results in increased expression of VCAM1 mRNA] CTD PMID:38115276 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vdr vitamin D receptor multiple interactions ISO Captopril promotes the reaction [LEPR protein affects the expression of VDR protein] CTD PMID:28130181 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Captopril inhibits the reaction [LEPR protein affects the expression of VEGFA mRNA] CTD PMID:28130181 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vim vimentin multiple interactions ISO Captopril inhibits the reaction [AGT protein results in increased expression of VIM protein]; Captopril inhibits the reaction [Silicon Dioxide results in increased expression of VIM protein] CTD PMID:33007385 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
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Term Annotations click to browse term
  CHEBI ontology 19867
    role 19837
      application 19682
        pharmaceutical 19517
          drug 19517
            cardiovascular drug 8642
              antihypertensive agent 1946
                captopril 44
                  captopril disulfide 0
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  CHEBI ontology 19867
    subatomic particle 19865
      composite particle 19865
        hadron 19865
          baryon 19865
            nucleon 19865
              atomic nucleus 19865
                atom 19865
                  main group element atom 19803
                    main group molecular entity 19803
                      s-block molecular entity 19638
                        hydrogen molecular entity 19620
                          hydrides 19141
                            inorganic hydride 18156
                              pnictogen hydride 18146
                                nitrogen hydride 18059
                                  azane 17868
                                    ammonia 17867
                                      organic amino compound 17867
                                        amino acid 16057
                                          alpha-amino acid 13929
                                            L-alpha-amino acid 12141
                                              glutamine family amino acid 10323
                                                L-proline 299
                                                  L-proline derivative 275
                                                    captopril 44
                                                      captopril disulfide 0
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