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ONTOLOGY REPORT - ANNOTATIONS


Term:captopril
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Accession:CHEBI:3380 term browser browse the term
Definition:A L-proline derivative in which L-proline is substituted on nitrogen with a (2S)-2-methyl-3-sulfanylpropanoyl group. It is used as an anti-hypertensive ACE inhibitor drug.
Synonyms:exact_synonym: 1-[(2S)-2-methyl-3-sulfanylpropanoyl]-L-proline
 related_synonym: (2S)-1-[(2S)-2-methyl-3-sulfanylpropanoyl]pyrrolidine-2-carboxylic acid;   Acepress;   Apopril;   CP;   Capoten;   Captolane;   Captopryl;   Captoril;   Cesplon;   D-2-methyl-3-mercaptopropanoyl-L-proline;   D-3-mercapto-2-methylpropanoyl-L-proline;   Dilabar;   Formula=C9H15NO3S;   Garranil;   Hypertil;   InChI=1S/C9H15NO3S/c1-6(5-14)8(11)10-4-2-3-7(10)9(12)13/h6-7,14H,2-5H2,1H3,(H,12,13)/t6-,7+/m1/s1;   InChIKey=FAKRSMQSSFJEIM-RQJHMYQMSA-N;   L-Captopril;   Lopirin;   SMILES=C[C@H](CS)C(=O)N1CCC[C@H]1C(O)=O;   Tenosbon;   Tensobon;   Tensoprel;   captoprilum
 xref: Beilstein:477887;   CAS:62571-86-2;   DrugBank:DB01197;   Drug_Central:484;   KEGG:D00251;   LINCS:LSM-5648
 xref_mesh: MESH:D002216
 xref: PMID:23137627;   PMID:23161035;   PMID:23278692;   PMID:23299024;   PMID:23328620;   PMID:23397376;   PMID:23410042;   PMID:23422724;   PMID:23429803;   PMID:23435971;   PMID:2420897;   Patent:US4046889;   Patent:US4105776;   Wikipedia:Captopril


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captopril term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:6480464
G Ace2 angiotensin I converting enzyme 2 JBrowse link X 32,050,734 32,095,860 RGD:6480464
G Acta2 actin alpha 2, smooth muscle JBrowse link 1 252,537,614 252,550,394 RGD:6480464
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:6480464
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:6480464
G Gli1 GLI family zinc finger 1 JBrowse link 7 70,620,794 70,633,171 RGD:6480464
G Gli2 GLI family zinc finger 2 JBrowse link 13 34,829,021 35,049,172 RGD:6480464
G Gli3 GLI family zinc finger 3 JBrowse link 17 52,294,942 52,569,036 RGD:6480464
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor JBrowse link 1 48,076,761 48,108,218 RGD:6480464
G Nppb natriuretic peptide B JBrowse link 5 164,796,176 164,797,538 RGD:6480464
G Prkaca protein kinase cAMP-activated catalytic subunit alpha JBrowse link 19 25,095,089 25,118,869 RGD:6480464
G Ptch1 patched 1 JBrowse link 17 1,032,242 1,085,885 RGD:6480464
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:6480464
G Smo smoothened, frizzled class receptor JBrowse link 4 57,019,941 57,041,779 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19790
    role 19738
      application 19385
        pharmaceutical 19254
          drug 19254
            cardiovascular drug 7617
              antihypertensive agent 1663
                captopril 14
                  captopril disulfide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19790
    subatomic particle 19788
      composite particle 19788
        hadron 19788
          baryon 19788
            nucleon 19788
              atomic nucleus 19788
                atom 19788
                  main group element atom 19674
                    p-block element atom 19674
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic group 18475
                              organic divalent group 18468
                                organodiyl group 18468
                                  carbonyl group 18366
                                    carbonyl compound 18366
                                      carboxylic acid 18034
                                        amino acid 12477
                                          alpha-amino acid 7712
                                            L-alpha-amino acid 7383
                                              glutamine family amino acid 5368
                                                L-proline 256
                                                  L-proline derivative 240
                                                    captopril 14
                                                      captopril disulfide 0
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