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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:nickel group molecular entity
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Accession:CHEBI:33747 term browser browse the term
Synonyms:related_synonym: nickel group molecular entities


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cisplatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 multiple interactions EXP Cisplatin inhibits the reaction [ABCB1 protein results in increased susceptibility to NSC73306] CTD PMID:24800945 NCBI chr 9:93,049,955...93,146,469 JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 affects response to substance EXP AIFM1 protein affects the susceptibility to Cisplatin CTD PMID:15983031 NCBI chr  X:106,676,596...106,708,290
Ensembl chr  X:106,670,519...106,708,317 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
affects localization		 EXP Bezafibrate inhibits the reaction [Cisplatin affects the localization of BAX protein] CTD PMID:16316343 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144 		JBrowse link
G CASP2 caspase 2 increases expression EXP Cisplatin results in increased expression of CASP2 CTD PMID:12712633 NCBI chr18:6,946,432...6,966,088
Ensembl chr18:6,902,542...6,966,092 		JBrowse link
G CASP3 caspase 3 increases expression
multiple interactions
increases activity		 EXP Cisplatin results in increased expression of CASP3
[Cisplatin co-treated with EPO protein] results in increased cleavage of CASP3 protein; Bezafibrate inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]; Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]; Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein		 CTD PMID:12712633 PMID:16316343 PMID:20435919 PMID:21497595 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773 		JBrowse link
G CASP8 caspase 8 increases activity
increases expression
multiple interactions		 EXP Cisplatin results in increased activity of CASP8 protein
Cisplatin results in increased expression of CASP8
Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP8 protein]		 CTD PMID:12712633 PMID:20435919 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,470 		JBrowse link
G CASP9 caspase 9 increases expression
increases activity		 EXP Cisplatin results in increased expression of CASP9
Cisplatin results in increased activity of CASP9 protein		 CTD PMID:12712633 PMID:20435919 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,515...74,730,092 		JBrowse link
G CYCS cytochrome c, somatic affects localization
multiple interactions		 EXP Cisplatin affects the localization of CYCS protein
Bezafibrate inhibits the reaction [Cisplatin affects the localization of CYCS protein]		 CTD PMID:16316343 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866 		JBrowse link
G EPO erythropoietin multiple interactions EXP [Cisplatin co-treated with EPO protein] results in increased cleavage of CASP3 protein CTD PMID:21497595 NCBI chr 3:8,620,508...8,622,936
Ensembl chr 3:8,620,508...8,622,936 		JBrowse link
G FAS Fas cell surface death receptor increases expression EXP Cisplatin results in increased expression of FAS mRNA CTD PMID:20435919 NCBI chr14:100,927,305...100,954,781 JBrowse link
G FASLG Fas ligand multiple interactions
affects localization		 EXP Cilastatin inhibits the reaction [Cisplatin affects the localization of FASLG protein] CTD PMID:20435919 NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,475 		JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit multiple interactions EXP Buthionine Sulfoximine inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]]; sulforaphane inhibits the reaction [Cisplatin results in decreased activity of GCLC protein] CTD PMID:20732396 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535 		JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of MYC] CTD PMID:12712633 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,119...12,461,078 		JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP Dicumarol inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein]]; sulforaphane inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein] CTD PMID:20732396 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,769...17,302,590 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases activity
multiple interactions		 EXP Cisplatin results in increased activity of PARP1 protein
N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide hydrochloride inhibits the reaction [Cisplatin results in increased activity of PARP1 protein]		 CTD PMID:25806124 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197 		JBrowse link
G PPARA peroxisome proliferator activated receptor alpha decreases activity
multiple interactions		 EXP Cisplatin results in decreased activity of PPARA protein
[Cisplatin results in decreased activity of PPARA protein] which results in increased abundance of Fatty Acids, Nonesterified; Bezafibrate inhibits the reaction [[Cisplatin results in decreased activity of PPARA protein] which results in increased abundance of Fatty Acids, Nonesterified]; Bezafibrate inhibits the reaction [Cisplatin results in decreased activity of PPARA protein]		 CTD PMID:16316343 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,708...3,366,361 		JBrowse link
G TNF tumor necrosis factor increases expression EXP Cisplatin results in increased expression of TNF mRNA CTD PMID:20435919 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655 		JBrowse link
G TP53 tumor protein p53 increases expression
multiple interactions		 EXP Cisplatin results in increased expression of TP53
mangostin inhibits the reaction [Cisplatin results in increased expression of TP53]		 CTD PMID:12712633 PMID:20603111 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 1029
    chemical entity 1029
      molecular entity 1016
        transition element molecular entity 196
          nickel group molecular entity 18
            darmstadtium molecular entity 0
            nickel molecular entity + 0
            palladium molecular entity + 0
            platinum molecular entity + 18
Path 2
Term Annotations click to browse term
  CHEBI ontology 1029
    subatomic particle 1003
      composite particle 1014
        hadron 1014
          baryon 1014
            nucleon 1014
              atomic nucleus 1014
                atom 1014
                  metal atom 235
                    transition element atom 198
                      d-block element atom 196
                        nickel group element atom 20
                          nickel group molecular entity 18
                            darmstadtium molecular entity 0
                            nickel molecular entity + 0
                            palladium molecular entity + 0
                            platinum molecular entity + 18
paths to the root