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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:manganese group molecular entity
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Accession:CHEBI:33743 term browser browse the term
Synonyms:related_synonym: manganese group molecular entities



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mancozeb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Cartwright blood group) affects activity
multiple interactions
ISO mancozeb affects the activity of ACHE protein
[carbendazim co-treated with mancozeb] results in increased activity of ACHE protein
CTD PMID:10641187 PMID:33217513 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ACTG1 actin gamma 1 increases expression ISO mancozeb results in increased expression of ACTG1 protein CTD PMID:21375462 NCBI chr17:81,509,971...81,512,799
Ensembl chr17:81,509,413...81,523,847
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of AKT1 protein; [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of AKT1 protein CTD PMID:19883720 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALB albumin decreases expression ISO mancozeb results in decreased expression of ALB protein CTD PMID:21375462 NCBI chr 4:73,404,287...73,421,482
Ensembl chr 4:73,397,114...73,421,482
JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member decreases activity ISO mancozeb results in decreased activity of ALDH2 protein CTD PMID:17010440 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532
JBrowse link
G ALDH5A1 aldehyde dehydrogenase 5 family member A1 decreases activity ISO mancozeb results in decreased activity of ALDH5A1 protein CTD PMID:17010440 NCBI chr 6:24,494,969...24,537,207
Ensembl chr 6:24,494,867...24,537,207
JBrowse link
G ANGPTL1 angiopoietin like 1 decreases expression EXP mancozeb results in decreased expression of ANGPTL1 mRNA CTD PMID:33396126 NCBI chr 1:178,849,535...178,871,077
Ensembl chr 1:178,849,535...178,871,077
JBrowse link
G ANXA2 annexin A2 decreases expression ISO mancozeb results in decreased expression of ANXA2 protein CTD PMID:21375462 NCBI chr15:60,347,151...60,398,025
Ensembl chr15:60,347,134...60,402,883
JBrowse link
G APAF1 apoptotic peptidase activating factor 1 increases expression EXP mancozeb results in increased expression of APAF1 protein CTD PMID:22289270 NCBI chr12:98,645,141...98,735,433
Ensembl chr12:98,645,290...98,735,433
JBrowse link
G AR androgen receptor multiple interactions
decreases expression
decreases activity
EXP mancozeb inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; mancozeb inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]
mancozeb results in decreased expression of AR mRNA
mancozeb results in decreased activity of AR protein
CTD PMID:23871939 PMID:33396126 NCBI chr  X:67,544,021...67,730,619
Ensembl chr  X:67,544,021...67,730,619
JBrowse link
G ATP1A2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression EXP mancozeb results in decreased expression of ATP1A2 mRNA CTD PMID:33396126 NCBI chr 1:160,115,759...160,143,591
Ensembl chr 1:160,115,759...160,143,591
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions
EXP mancozeb results in increased expression of BAX mRNA; mancozeb results in increased expression of BAX protein
lupeol inhibits the reaction [mancozeb results in increased expression of BAX mRNA]
CTD PMID:22289270 PMID:27235710 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions
EXP
ISO
mancozeb results in decreased expression of BCL2 mRNA; mancozeb results in decreased expression of BCL2 protein
lupeol inhibits the reaction [mancozeb results in decreased expression of BCL2 mRNA]
alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of BCL2 protein]
CTD PMID:16005924 PMID:22289270 PMID:27235710 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G C19orf54 chromosome 19 open reading frame 54 decreases expression EXP mancozeb results in decreased expression of C19ORF54 mRNA CTD PMID:33396126 NCBI chr19:40,740,856...40,751,372
Ensembl chr19:40,740,856...40,751,553
JBrowse link
G CA3 carbonic anhydrase 3 increases expression ISO mancozeb results in increased expression of CAR3 protein CTD PMID:21375462 NCBI chr 8:85,438,859...85,449,040
Ensembl chr 8:85,373,436...85,449,040
JBrowse link
G CASP3 caspase 3 increases activity
multiple interactions
increases cleavage
EXP
ISO
mancozeb results in increased activity of CASP3 protein
Acetylcysteine inhibits the reaction [mancozeb results in increased cleavage of CASP3 protein]
mancozeb results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:22289270 PMID:22824503 PMID:30037311 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP7 caspase 7 increases activity EXP mancozeb results in increased activity of CASP7 protein CTD PMID:22824503 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP8 caspase 8 increases activity EXP mancozeb results in increased activity of CASP8 protein CTD PMID:22289270 PMID:22824503 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 increases activity
multiple interactions
EXP mancozeb results in increased activity of CASP9 protein
mancozeb results in increased cleavage of and results in increased activity of CASP9 protein
CTD PMID:22289270 PMID:22824503 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions
decreases activity
EXP
ISO
Acetylcysteine inhibits the reaction [mancozeb results in decreased activity of CAT protein]; lupeol inhibits the reaction [mancozeb results in decreased activity of CAT protein]; Quercetin inhibits the reaction [mancozeb results in decreased activity of CAT protein]
Colforsin inhibits the reaction [mancozeb results in decreased activity of CAT protein]
CTD PMID:23024109 PMID:27235710 PMID:29283200 PMID:30037311 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCDC106 coiled-coil domain containing 106 decreases expression EXP mancozeb results in decreased expression of CCDC106 mRNA CTD PMID:33396126 NCBI chr19:55,647,400...55,653,161
Ensembl chr19:55,641,062...55,653,161
JBrowse link
G CCND1 cyclin D1 multiple interactions
increases expression
ISO
EXP
[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of CCND1 protein
mancozeb results in increased expression of CCND1 protein
CTD PMID:19883720 PMID:21375462 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CDC25C cell division cycle 25C increases phosphorylation EXP mancozeb results in increased phosphorylation of CDC25C protein CTD PMID:21375462 NCBI chr 5:138,285,265...138,338,355
Ensembl chr 5:138,285,269...138,338,355
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions
increases expression
EXP lupeol inhibits the reaction [mancozeb results in increased expression of CDKN1A mRNA] CTD PMID:27235710 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CFAP126 cilia and flagella associated protein 126 decreases expression EXP mancozeb results in decreased expression of CFAP126 mRNA CTD PMID:33396126 NCBI chr 1:161,364,733...161,367,876
Ensembl chr 1:161,364,733...161,367,876
JBrowse link
G CLDN16 claudin 16 decreases expression EXP mancozeb results in decreased expression of CLDN16 mRNA CTD PMID:33396126 NCBI chr 3:190,290,361...190,412,138
Ensembl chr 3:190,322,541...190,412,138
JBrowse link
G CTF1 cardiotrophin 1 decreases expression EXP mancozeb results in decreased expression of CTF1 mRNA CTD PMID:33396126 NCBI chr16:30,895,824...30,903,560
Ensembl chr16:30,896,614...30,903,547
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of CXCL8 protein] CTD PMID:16112155 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYCS cytochrome c, somatic increases expression EXP mancozeb results in increased expression of CYCS protein CTD PMID:27016407 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 decreases activity
decreases expression
ISO
EXP
mancozeb results in decreased activity of CYP1A1 protein
mancozeb results in decreased expression of CYP1A1 protein
CTD PMID:1946188 PMID:31096615 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP2B6 cytochrome P450 family 2 subfamily B member 6 decreases expression EXP mancozeb results in decreased expression of CYP2B6 protein CTD PMID:31096615 NCBI chr19:40,991,282...41,018,398
Ensembl chr19:40,991,282...41,018,398
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases expression EXP mancozeb results in decreased expression of CYP2E1 mRNA CTD PMID:31096615 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases expression EXP mancozeb results in decreased expression of CYP3A4 mRNA; mancozeb results in decreased expression of CYP3A4 protein CTD PMID:31096615 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DDIT4 DNA damage inducible transcript 4 increases expression ISO mancozeb results in increased expression of DDIT4 protein CTD PMID:24764117 NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036
JBrowse link
G EFCAB12 EF-hand calcium binding domain 12 decreases expression EXP mancozeb results in decreased expression of EFCAB12 mRNA CTD PMID:33396126 NCBI chr 3:129,401,321...129,428,636
Ensembl chr 3:129,401,321...129,428,651
JBrowse link
G ELK1 ETS transcription factor ELK1 increases phosphorylation EXP mancozeb results in increased phosphorylation of ELK1 protein CTD PMID:21375462 NCBI chr  X:47,635,520...47,650,604
Ensembl chr  X:47,635,521...47,650,604
JBrowse link
G ESR1 estrogen receptor 1 decreases expression EXP mancozeb results in decreased expression of ESR1 mRNA CTD PMID:33396126 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G ESR2 estrogen receptor 2 decreases expression EXP mancozeb results in decreased expression of ESR2 mRNA; mancozeb results in decreased expression of ESR2 protein CTD PMID:33396126 NCBI chr14:64,226,707...64,338,631
Ensembl chr14:64,084,232...64,338,112
JBrowse link
G F3 coagulation factor III, tissue factor increases expression EXP mancozeb results in increased expression of F3 protein CTD PMID:25569083 NCBI chr 1:94,529,173...94,541,759
Ensembl chr 1:94,529,173...94,541,759
JBrowse link
G FAS Fas cell surface death receptor increases expression EXP mancozeb results in increased expression of FAS protein CTD PMID:22289270 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,953,813...89,029,605
JBrowse link
G FASLG Fas ligand increases expression EXP mancozeb results in increased expression of FASLG protein CTD PMID:22289270 NCBI chr 1:172,659,103...172,666,876
Ensembl chr 1:172,659,103...172,666,876
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha increases expression
multiple interactions
EXP mancozeb results in increased expression of GADD45A mRNA
lupeol inhibits the reaction [mancozeb results in increased expression of GADD45A mRNA]
CTD PMID:27235710 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G GLYATL3 glycine-N-acyltransferase like 3 decreases expression EXP mancozeb results in decreased expression of GLYATL3 mRNA CTD PMID:33396126 NCBI chr 6:49,499,923...49,528,078
Ensembl chr 6:49,499,923...49,528,078
JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 affects activity ISO mancozeb affects the activity of GOT1 protein CTD PMID:10641187 NCBI chr10:99,396,870...99,430,624
Ensembl chr10:99,396,870...99,430,624
JBrowse link
G GPT glutamic--pyruvic transaminase affects activity ISO mancozeb affects the activity of GPT protein CTD PMID:10641187 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
G GPX1 glutathione peroxidase 1 decreases expression
multiple interactions
ISO mancozeb results in decreased expression of GPX1 mRNA
Acetylcysteine inhibits the reaction [mancozeb results in decreased expression of GPX1 mRNA]
CTD PMID:30037311 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,353
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein CTD PMID:19883720 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G HDAC3 histone deacetylase 3 decreases activity EXP mancozeb results in decreased activity of HDAC3 protein CTD PMID:21251949 NCBI chr 5:141,620,881...141,636,849
Ensembl chr 5:141,620,876...141,636,849
JBrowse link
G HDAC6 histone deacetylase 6 decreases activity EXP mancozeb results in decreased activity of HDAC6 protein CTD PMID:21251949 NCBI chr  X:48,801,398...48,824,982
Ensembl chr  X:48,801,377...48,824,982
JBrowse link
G HNRNPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1 decreases expression EXP mancozeb results in decreased expression of HNRNPA3P1 mRNA CTD PMID:33396126 NCBI chr10:43,787,412...43,790,417
Ensembl chr10:43,789,249...43,790,387
JBrowse link
G HNRNPM heterogeneous nuclear ribonucleoprotein M increases expression ISO mancozeb results in increased expression of HNRNPM protein CTD PMID:21375462 NCBI chr19:8,444,575...8,489,114
Ensembl chr19:8,444,767...8,489,114
JBrowse link
G IFITM2 interferon induced transmembrane protein 2 decreases expression EXP mancozeb results in decreased expression of IFITM2 mRNA CTD PMID:33396126 NCBI chr11:307,816...309,395
Ensembl chr11:303,655...309,397
JBrowse link
G IFNG interferon gamma multiple interactions ISO mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein] CTD PMID:15742816 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IGHM immunoglobulin heavy constant mu increases expression EXP mancozeb results in increased expression of IGHM mRNA CTD PMID:33396126 NCBI chr14:105,851,966...105,856,217
Ensembl chr14:105,851,705...105,856,218
JBrowse link
G IGHV3-38 immunoglobulin heavy variable 3-38 (non-functional) decreases expression EXP mancozeb results in decreased expression of IGHV3-38 mRNA CTD PMID:33396126 NCBI chr14:106,410,494...106,410,943
Ensembl chr14:106,410,493...106,411,021
JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein] CTD PMID:16112155 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL2 interleukin 2 affects expression EXP mancozeb affects the expression of IL2 protein CTD PMID:9012323 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G ITGB3 integrin subunit beta 3 decreases expression EXP mancozeb results in decreased expression of ITGB3 mRNA; mancozeb results in decreased expression of ITGB3 protein CTD PMID:33396126 NCBI chr17:47,253,827...47,313,743
Ensembl chr17:47,253,827...47,313,743
JBrowse link
G KCNQ2 potassium voltage-gated channel subfamily Q member 2 increases activity ISO mancozeb results in increased activity of KCNQ2 protein CTD PMID:23542819 NCBI chr20:63,400,208...63,472,655
Ensembl chr20:63,400,208...63,472,677
JBrowse link
G KISS1 KiSS-1 metastasis suppressor affects expression ISO mancozeb affects the expression of KISS1 mRNA CTD PMID:23660487 NCBI chr 1:204,190,341...204,196,491
Ensembl chr 1:204,190,341...204,196,491
JBrowse link
G KRT6A keratin 6A decreases expression ISO mancozeb results in decreased expression of KRT6A protein CTD PMID:21375462 NCBI chr12:52,487,176...52,493,257
Ensembl chr12:52,487,176...52,493,257
JBrowse link
G KRTAP2-2 keratin associated protein 2-2 decreases expression EXP mancozeb results in decreased expression of KRTAP2-2 mRNA CTD PMID:33396126 NCBI chr17:41,054,498...41,055,230
Ensembl chr17:41,054,498...41,055,230
JBrowse link
G LTB4R2 leukotriene B4 receptor 2 increases expression EXP mancozeb results in increased expression of LTB4R2 mRNA CTD PMID:33396126 NCBI chr14:24,310,140...24,312,038
Ensembl chr14:24,305,734...24,312,053
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK1 protein]; mancozeb results in increased localization of and results in increased activity of MAPK1 protein CTD PMID:21375462 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK3 protein]; mancozeb results in increased localization of and results in increased activity of MAPK3 protein CTD PMID:21375462 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MDM2 MDM2 proto-oncogene multiple interactions
increases expression
EXP lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA] CTD PMID:27235710 NCBI chr12:68,808,149...68,850,686
Ensembl chr12:68,808,177...68,845,544
JBrowse link
G MIR3685 microRNA 3685 decreases expression EXP mancozeb results in decreased expression of MIR3685 mRNA CTD PMID:33396126 NCBI chr12:95,309,923...95,309,984
Ensembl chr12:95,309,923...95,309,984
JBrowse link
G MIR421 microRNA 421 increases expression EXP mancozeb results in increased expression of MIR421 mRNA CTD PMID:33396126 NCBI chr  X:74,218,377...74,218,461
Ensembl chr  X:74,218,377...74,218,461
JBrowse link
G MIR4267 microRNA 4267 increases expression EXP mancozeb results in increased expression of MIR4267 mRNA CTD PMID:33396126 NCBI chr 2:110,069,961...110,070,042
Ensembl chr 2:110,069,961...110,070,042
JBrowse link
G MUC1 mucin 1, cell surface associated decreases expression EXP mancozeb results in decreased expression of MUC1 mRNA; mancozeb results in decreased expression of MUC1 protein CTD PMID:33396126 NCBI chr 1:155,185,824...155,192,915
Ensembl chr 1:155,185,824...155,192,916
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions
increases expression
decreases expression
ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of MYC protein
mancozeb results in increased expression of MYC protein
mancozeb results in decreased expression of MYC protein
alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of MYC protein]
CTD PMID:16005924 PMID:19883720 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 decreases expression EXP mancozeb results in decreased expression of NHLRC1 mRNA CTD PMID:33396126 NCBI chr 6:18,120,440...18,122,677
Ensembl chr 6:18,120,440...18,122,677
JBrowse link
G NOS2 nitric oxide synthase 2 increases expression
multiple interactions
ISO mancozeb results in increased expression of NOS2 mRNA
Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOS2 mRNA]
CTD PMID:30037311 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOX4 NADPH oxidase 4 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOX4 mRNA] CTD PMID:30037311 NCBI chr11:89,324,353...89,589,557
Ensembl chr11:89,324,353...89,498,187
JBrowse link
G NPIPB11 nuclear pore complex interacting protein family member B11 increases expression EXP mancozeb results in increased expression of NPIPB11 mRNA CTD PMID:33396126 NCBI chr16:29,381,310...29,406,711
Ensembl chr16:29,381,354...29,404,029
JBrowse link
G ODC1 ornithine decarboxylase 1 increases activity ISO mancozeb results in increased activity of ODC1 protein CTD PMID:1733566 NCBI chr 2:10,439,968...10,448,327
Ensembl chr 2:10,439,968...10,448,327
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase multiple interactions
decreases expression
EXP lupeol inhibits the reaction [mancozeb results in decreased expression of OGG1 mRNA] CTD PMID:27235710 NCBI chr 3:9,749,952...9,788,246
Ensembl chr 3:9,749,944...9,788,219
JBrowse link
G OR1S1 olfactory receptor family 1 subfamily S member 1 increases expression EXP mancozeb results in increased expression of OR1S1 mRNA CTD PMID:33396126 NCBI chr11:58,212,720...58,216,084
Ensembl chr11:58,212,720...58,216,084
JBrowse link
G OR2L3 olfactory receptor family 2 subfamily L member 3 decreases expression EXP mancozeb results in decreased expression of OR2L3 mRNA CTD PMID:33396126 NCBI chr 1:248,046,836...248,063,407
Ensembl chr 1:248,046,836...248,063,407
JBrowse link
G PCDHB14 protocadherin beta 14 decreases expression EXP mancozeb results in decreased expression of PCDHB14 mRNA CTD PMID:33396126 NCBI chr 5:141,223,343...141,227,759
Ensembl chr 5:141,223,343...141,227,759
JBrowse link
G PRDX2 peroxiredoxin 2 increases expression ISO mancozeb results in increased expression of PRDX2 protein CTD PMID:21375462 NCBI chr19:12,796,823...12,801,800
Ensembl chr19:12,796,820...12,801,800
JBrowse link
G PRL prolactin multiple interactions
increases expression
ISO
EXP
[mancozeb co-treated with imidacloprid] results in increased expression of PRL protein
mancozeb results in increased expression of PRL mRNA
CTD PMID:24530807 PMID:33396126 NCBI chr 6:22,287,246...22,302,897
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G PTGES prostaglandin E synthase increases expression
decreases expression
multiple interactions
EXP
ISO
mancozeb results in increased expression of PTGES mRNA
mancozeb results in decreased expression of PTGES protein
lupeol inhibits the reaction [mancozeb results in increased expression of PTGES mRNA]
CTD PMID:27235710 PMID:32446389 NCBI chr 9:129,738,349...129,753,042
Ensembl chr 9:129,738,331...129,753,042
JBrowse link
G PTGES3 prostaglandin E synthase 3 decreases expression ISO mancozeb results in decreased expression of PTGES3 mRNA CTD PMID:32446389 NCBI chr12:56,663,349...56,689,575
Ensembl chr12:56,663,341...56,688,408
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP
ISO
mancozeb results in increased expression of PTGS2 protein CTD PMID:21375462 PMID:32446389 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922
JBrowse link
G PTK2B protein tyrosine kinase 2 beta multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form CTD PMID:19883720 NCBI chr 8:27,311,478...27,459,391
Ensembl chr 8:27,311,482...27,459,391
JBrowse link
G PVALB parvalbumin increases expression ISO mancozeb results in increased expression of PVALB protein CTD PMID:21375462 NCBI chr22:36,800,703...36,819,499
Ensembl chr22:36,800,684...36,819,479
JBrowse link
G RB1-DT RB1 divergent transcript decreases expression EXP mancozeb results in decreased expression of RB1-DT mRNA CTD PMID:33396126 NCBI chr13:48,296,513...48,303,702
Ensembl chr13:48,296,162...48,303,702
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit increases phosphorylation
affects localization
multiple interactions
increases localization
EXP mancozeb results in increased phosphorylation of RELA protein
mancozeb affects the localization of RELA protein
Acetylcysteine inhibits the reaction [mancozeb affects the localization of RELA protein]; lupeol inhibits the reaction [mancozeb affects the localization of RELA protein]; mancozeb inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]
mancozeb results in increased localization of RELA protein
CTD PMID:16112155 PMID:21375462 PMID:22289270 PMID:27235710 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G S100A6 S100 calcium binding protein A6 increases expression ISO
EXP
mancozeb results in increased expression of S100A6 protein CTD PMID:21375462 NCBI chr 1:153,534,599...153,536,049
Ensembl chr 1:153,534,599...153,536,244
JBrowse link
G S100A9 S100 calcium binding protein A9 increases expression ISO
EXP
mancozeb results in increased expression of S100A9 protein CTD PMID:21375462 NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023
JBrowse link
G SCX scleraxis bHLH transcription factor decreases expression EXP mancozeb results in decreased expression of SCX mRNA CTD PMID:33396126 NCBI chr 8:144,265,060...144,268,483
Ensembl chr 8:144,266,453...144,268,481
JBrowse link
G SEPTIN11 septin 11 increases expression EXP mancozeb results in increased expression of SEPTIN11 mRNA CTD PMID:33396126 NCBI chr 4:76,949,752...77,040,154
Ensembl chr 4:76,949,751...77,040,384
JBrowse link
G SERPINF1 serpin family F member 1 decreases expression EXP mancozeb results in decreased expression of SERPINF1 mRNA CTD PMID:33396126 NCBI chr17:1,762,060...1,777,565
Ensembl chr17:1,762,029...1,777,565
JBrowse link
G SIRT1 sirtuin 1 decreases activity EXP mancozeb results in decreased activity of SIRT1 protein CTD PMID:21251949 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SIRT2 sirtuin 2 decreases activity EXP mancozeb results in decreased activity of SIRT2 protein CTD PMID:21251949 NCBI chr19:38,878,555...38,899,733
Ensembl chr19:38,878,555...38,899,862
JBrowse link
G SIRT3 sirtuin 3 decreases activity EXP mancozeb results in decreased activity of SIRT3 protein CTD PMID:21251949 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931
JBrowse link
G SLC14A1 solute carrier family 14 member 1 (Kidd blood group) decreases expression EXP mancozeb results in decreased expression of SLC14A1 mRNA CTD PMID:33396126 NCBI chr18:45,724,127...45,752,520
Ensembl chr18:45,687,025...45,752,520
JBrowse link
G SLC5A5 solute carrier family 5 member 5 multiple interactions EXP mancozeb inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine] CTD PMID:27979590 NCBI chr19:17,871,394...17,895,175
Ensembl chr19:17,871,945...17,895,174
JBrowse link
G SNORD82 small nucleolar RNA, C/D box 82 increases expression EXP mancozeb results in increased expression of SNORD82 mRNA CTD PMID:33396126 NCBI chr 2:231,460,368...231,460,442
Ensembl chr 2:231,460,371...231,460,440
JBrowse link
G SOD1 superoxide dismutase 1 decreases expression ISO mancozeb results in decreased expression of SOD1 protein CTD PMID:21375462 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SULT2B1 sulfotransferase family 2B member 1 decreases expression EXP mancozeb results in decreased expression of SULT2B1 mRNA CTD PMID:33396126 NCBI chr19:48,552,172...48,599,427
Ensembl chr19:48,552,172...48,599,425
JBrowse link
G TEK TEK receptor tyrosine kinase increases activity EXP mancozeb results in increased activity of TEK protein CTD PMID:21251949 NCBI chr 9:27,109,141...27,230,178
Ensembl chr 9:27,109,141...27,230,174
JBrowse link
G TGFB1I1 transforming growth factor beta 1 induced transcript 1 decreases expression EXP mancozeb results in decreased expression of TGFB1I1 mRNA CTD PMID:33396126 NCBI chr16:31,472,152...31,477,960
Ensembl chr16:31,471,585...31,477,960
JBrowse link
G TNF tumor necrosis factor multiple interactions ISO
EXP
mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]
mancozeb inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; mancozeb inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]
CTD PMID:15742816 PMID:15893782 PMID:16112155 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TP53 tumor protein p53 decreases expression
increases expression
multiple interactions
EXP
ISO
mancozeb results in decreased expression of TRP53 mRNA; mancozeb results in decreased expression of TRP53 protein
mancozeb results in increased expression of TP53 mRNA
lupeol inhibits the reaction [mancozeb results in increased expression of TP53 mRNA]
CTD PMID:22369882 PMID:27235710 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TPI1 triosephosphate isomerase 1 increases expression ISO mancozeb results in increased expression of TPI1 protein CTD PMID:21375462 NCBI chr12:6,866,834...6,870,948
Ensembl chr12:6,867,119...6,870,948
JBrowse link
G TPO thyroid peroxidase decreases activity ISO mancozeb results in decreased activity of TPO protein CTD PMID:9418944 NCBI chr 2:1,413,288...1,543,673
Ensembl chr 2:1,374,066...1,543,711
JBrowse link
G TSHB thyroid stimulating hormone subunit beta multiple interactions ISO [mancozeb co-treated with imidacloprid] results in increased expression of TSHB protein CTD PMID:24530807 NCBI chr 1:115,029,826...115,035,935
Ensembl chr 1:115,029,826...115,034,302
JBrowse link
G XRCC1 X-ray repair cross complementing 1 multiple interactions
decreases expression
EXP lupeol inhibits the reaction [mancozeb results in decreased expression of XRCC1 mRNA] CTD PMID:27235710 NCBI chr19:43,543,311...43,575,527
Ensembl chr19:43,543,311...43,580,473
JBrowse link
G ZNF358 zinc finger protein 358 decreases expression EXP mancozeb results in decreased expression of ZNF358 mRNA CTD PMID:33396126 NCBI chr19:7,515,286...7,521,025
Ensembl chr19:7,515,292...7,521,025
JBrowse link
maneb term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACADS acyl-CoA dehydrogenase short chain multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA] CTD PMID:23963992 NCBI chr12:120,725,826...120,740,008
Ensembl chr12:120,725,774...120,740,008
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions
decreases expression
ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of ACHE mRNA
Maneb results in decreased expression of ACHE protein
CTD PMID:3868355 PMID:23017109 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ACO2 aconitase 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ACO2 mRNA CTD PMID:18386188 NCBI chr22:41,468,756...41,528,979
Ensembl chr22:41,447,830...41,529,273
JBrowse link
G ADAM22 ADAM metallopeptidase domain 22 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ADAM22 mRNA CTD PMID:22563483 NCBI chr 7:87,934,163...88,202,889
Ensembl chr 7:87,934,143...88,202,889
JBrowse link
G ADGRB1 adhesion G protein-coupled receptor B1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ADGRB1 mRNA CTD PMID:23017109 NCBI chr 8:142,449,649...142,545,009
Ensembl chr 8:142,449,430...142,545,009
JBrowse link
G ADGRG1 adhesion G protein-coupled receptor G1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ADGRG1 mRNA CTD PMID:18386188 NCBI chr16:57,619,535...57,665,567
Ensembl chr16:57,610,652...57,665,580
JBrowse link
G ADORA1 adenosine A1 receptor multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ADORA1 mRNA CTD PMID:23017109 NCBI chr 1:203,127,705...203,167,405
Ensembl chr 1:203,090,654...203,167,405
JBrowse link
G AGO3 argonaute RISC catalytic component 3 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of AGO3 mRNA CTD PMID:22563483 NCBI chr 1:35,925,683...36,072,500
Ensembl chr 1:35,930,718...36,072,500
JBrowse link
G AIF1 allograft inflammatory factor 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of AIF1 protein; [Paraquat co-treated with Maneb] results in increased expression of AIF1 protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of AIF1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of AIF1 protein] CTD PMID:28202386 PMID:32375810 NCBI chr 6:31,615,212...31,617,015
Ensembl chr 6:31,615,217...31,617,021
JBrowse link
G AKR1B1 aldo-keto reductase family 1 member B multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of AKR1B3 mRNA CTD PMID:18386188 NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284
JBrowse link
G AKT1 AKT serine/threonine kinase 1 multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of AKT1 protein; [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of AKT1 protein; [Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA] CTD PMID:19883720 PMID:23963992 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ALAS2 mRNA CTD PMID:22563483 NCBI chr  X:55,009,055...55,030,977
Ensembl chr  X:55,009,055...55,030,977
JBrowse link
G ALDH2 aldehyde dehydrogenase 2 family member decreases activity ISO Maneb results in decreased activity of ALDH2 protein CTD PMID:17010440 NCBI chr12:111,766,933...111,817,532
Ensembl chr12:111,766,887...111,817,532
JBrowse link
G ALDH5A1 aldehyde dehydrogenase 5 family member A1 decreases activity
multiple interactions
ISO Maneb results in decreased activity of ALDH5A1 protein
[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]
CTD PMID:17010440 PMID:23963992 NCBI chr 6:24,494,969...24,537,207
Ensembl chr 6:24,494,867...24,537,207
JBrowse link
G ALDOC aldolase, fructose-bisphosphate C multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ALDOC mRNA CTD PMID:18386188 NCBI chr17:28,573,115...28,576,963
Ensembl chr17:28,573,115...28,576,948
JBrowse link
G AMN amnion associated transmembrane protein multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of AMN mRNA CTD PMID:22563483 NCBI chr14:102,922,430...102,933,597
Ensembl chr14:102,922,663...102,933,596
JBrowse link
G AP3B2 adaptor related protein complex 3 subunit beta 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of AP3B2 mRNA CTD PMID:18386188 NCBI chr15:82,659,281...82,709,875
Ensembl chr15:82,659,281...82,710,112
JBrowse link
G AP3D1 adaptor related protein complex 3 subunit delta 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of AP3D1 mRNA CTD PMID:18386188 NCBI chr19:2,100,988...2,151,566
Ensembl chr19:2,100,988...2,164,468
JBrowse link
G APBB1 amyloid beta precursor protein binding family B member 1 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of APBB1 mRNA CTD PMID:23017109 NCBI chr11:6,395,124...6,419,453
Ensembl chr11:6,395,125...6,419,414
JBrowse link
G ARF3 ADP ribosylation factor 3 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ARF3 mRNA CTD PMID:18386188 NCBI chr12:48,930,252...48,957,526
Ensembl chr12:48,935,723...48,957,487
JBrowse link
G ARG1 arginase 1 multiple interactions
decreases expression
ISO
EXP
[Paraquat co-treated with Maneb] results in increased expression of ARG1 mRNA
Maneb results in decreased expression of ARG1 mRNA
CTD PMID:29568078 PMID:32194361 PMID:32375810 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332
JBrowse link
G ARNT2 aryl hydrocarbon receptor nuclear translocator 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of ARNT2 mRNA CTD PMID:23017109 NCBI chr15:80,404,382...80,597,933
Ensembl chr15:80,404,350...80,597,933
JBrowse link
G ASCL1 achaete-scute family bHLH transcription factor 1 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ASCL1 mRNA CTD PMID:23017109 NCBI chr12:102,957,674...102,960,513
Ensembl chr12:102,957,674...102,960,513
JBrowse link
G ATG12 autophagy related 12 multiple interactions ISO Maneb promotes the reaction [Paraquat results in increased expression of ATG12 protein] CTD PMID:22292029 NCBI chr 5:115,828,200...115,841,565
Ensembl chr 5:115,828,200...115,841,837
JBrowse link
G ATP5F1A ATP synthase F1 subunit alpha multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein] CTD PMID:23562983 NCBI chr18:46,080,248...46,104,227
Ensembl chr18:46,080,248...46,104,334
JBrowse link
G ATP5MC1 ATP synthase membrane subunit c locus 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ATP5G1 mRNA CTD PMID:18386188 NCBI chr17:48,892,787...48,895,871
Ensembl chr17:48,892,765...48,895,871
JBrowse link
G ATP6V0B ATPase H+ transporting V0 subunit b multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ATP6V0B mRNA CTD PMID:18386188 NCBI chr 1:43,974,960...43,978,295
Ensembl chr 1:43,974,487...43,978,295
JBrowse link
G ATP6V0C ATPase H+ transporting V0 subunit c multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of ATP6V0C mRNA CTD PMID:18386188 NCBI chr16:2,513,726...2,520,218
Ensembl chr16:2,513,952...2,520,218
JBrowse link
G ATP6V1C1 ATPase H+ transporting V1 subunit C1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA] CTD PMID:23963992 NCBI chr 8:103,021,083...103,073,051
Ensembl chr 8:103,021,063...103,073,051
JBrowse link
G ATP8A2 ATPase phospholipid transporting 8A2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ATP8A2 mRNA CTD PMID:22563483 NCBI chr13:25,371,974...26,025,851
Ensembl chr13:25,371,974...26,025,851
JBrowse link
G BAD BCL2 associated agonist of cell death multiple interactions EXP [Paraquat co-treated with Maneb] results in increased phosphorylation of BAD protein CTD PMID:15824117 NCBI chr11:64,269,828...64,284,704
Ensembl chr11:64,269,830...64,284,704
JBrowse link
G BAK1 BCL2 antagonist/killer 1 multiple interactions
affects response to substance
increases expression
ISO
EXP
[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]
BAK1 protein affects the susceptibility to Maneb
[Paraquat co-treated with Maneb] results in increased expression of BAK1 protein; Maneb inhibits the reaction [BAK1 protein affects the susceptibility to Paraquat]; Paraquat inhibits the reaction [BAK1 protein affects the susceptibility to Maneb]
Maneb results in increased expression of BAK1 mRNA; Maneb results in increased expression of BAK1 protein
CTD PMID:18266926 PMID:23963992 NCBI chr 6:33,572,552...33,580,296
Ensembl chr 6:33,572,547...33,580,293
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
EXP
ISO
[Paraquat co-treated with Maneb] results in increased expression of BAX protein; BAX protein affects the susceptibility to [Paraquat co-treated with Maneb]
Maneb results in increased expression of BAX protein
[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA; [Paraquat co-treated with Maneb] results in increased expression of BAX protein; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]
CTD PMID:15824117 PMID:18266926 PMID:20964710 PMID:23963992 NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BBC3 BCL2 binding component 3 increases expression EXP Maneb results in increased expression of BBC3 protein CTD PMID:18266926 NCBI chr19:47,220,822...47,232,998
Ensembl chr19:47,220,822...47,232,766
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
increases expression
ISO
EXP
[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]
Maneb results in increased expression of BCL2 mRNA; Maneb results in increased expression of BCL2 protein
CTD PMID:18266926 PMID:23963992 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2A1 BCL2 related protein A1 multiple interactions
increases expression
EXP [Paraquat co-treated with Maneb] results in increased expression of BCL2A1 protein
Maneb results in increased expression of BCL2A1 mRNA
CTD PMID:18266926 NCBI chr15:79,960,892...79,971,196
Ensembl chr15:79,960,892...79,971,196
JBrowse link
G BCL2L1 BCL2 like 1 multiple interactions
increases expression
EXP [Paraquat co-treated with Maneb] results in decreased expression of BCL2L1 protein
Maneb results in increased expression of BCL2L1 mRNA
CTD PMID:15824117 PMID:18266926 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BCL2L11 BCL2 like 11 multiple interactions
increases expression
EXP [Paraquat co-treated with Maneb] results in increased expression of BCL2L11 protein
Maneb results in increased expression of BCL2L11 protein
CTD PMID:18266926 NCBI chr 2:111,120,914...111,168,445
Ensembl chr 2:111,119,378...111,168,445
JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of BDNF mRNA
[Paraquat co-treated with Maneb] results in decreased expression of BDNF mRNA; [Paraquat co-treated with Maneb] results in decreased expression of BDNF protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of BDNF mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of BDNF protein]
CTD PMID:23017109 PMID:27460631 PMID:33368748 NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G BECN1 beclin 1 increases expression
multiple interactions
ISO Maneb results in increased expression of BECN1 protein
[Paraquat co-treated with Maneb] results in increased expression of BECN1 protein
CTD PMID:22292029 PMID:26884967 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350
JBrowse link
G BICD1 BICD cargo adaptor 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of BICD1 mRNA CTD PMID:22563483 NCBI chr12:32,106,773...32,383,637
Ensembl chr12:32,106,835...32,383,633
JBrowse link
G BID BH3 interacting domain death agonist increases expression
multiple interactions
EXP Maneb results in increased expression of BID protein
[Maneb co-treated with Paraquat] results in increased expression of BID protein
CTD PMID:18266926 NCBI chr22:17,734,138...17,774,665
Ensembl chr22:17,734,138...17,774,770
JBrowse link
G BIK BCL2 interacting killer increases expression
multiple interactions
EXP Maneb results in increased expression of BIK mRNA; Maneb results in increased expression of BIK protein
[Paraquat co-treated with Maneb] results in increased expression of BIK protein
CTD PMID:18266926 NCBI chr22:43,110,750...43,129,712
Ensembl chr22:43,110,750...43,129,712
JBrowse link
G BMP2 bone morphogenetic protein 2 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP2 mRNA CTD PMID:23017109 NCBI chr20:6,767,686...6,780,246
Ensembl chr20:6,767,686...6,780,246
JBrowse link
G BMP4 bone morphogenetic protein 4 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA CTD PMID:23017109 NCBI chr14:53,949,736...53,956,891
Ensembl chr14:53,949,736...53,958,761
JBrowse link
G BNIP3 BCL2 interacting protein 3 increases expression EXP Maneb results in increased expression of BNIP3 mRNA; Maneb results in increased expression of BNIP3 protein CTD PMID:18266926 NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,967,684...131,981,967
JBrowse link
G BNIP3L BCL2 interacting protein 3 like increases expression EXP Maneb results in increased expression of BNIP3L mRNA CTD PMID:18266926 NCBI chr 8:26,383,054...26,413,127
Ensembl chr 8:26,383,054...26,505,636
JBrowse link
G BRF1 BRF1 RNA polymerase III transcription initiation factor subunit multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of BRF1 mRNA CTD PMID:18386188 NCBI chr14:105,209,286...105,315,589
Ensembl chr14:105,209,286...105,315,589
JBrowse link
G CACNA1E calcium voltage-gated channel subunit alpha1 E multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CACNA1E mRNA CTD PMID:22563483 NCBI chr 1:181,317,712...181,808,084
Ensembl chr 1:181,317,690...181,808,084
JBrowse link
G CACYBP calcyclin binding protein multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of CACYBP mRNA CTD PMID:18386188 NCBI chr 1:174,999,435...175,012,027
Ensembl chr 1:174,999,163...175,012,027
JBrowse link
G CALM1 calmodulin 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA] CTD PMID:23963992 NCBI chr14:90,396,502...90,408,268
Ensembl chr14:90,396,502...90,408,268
JBrowse link
G CALM2 calmodulin 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of CALM2 mRNA CTD PMID:18386188 NCBI chr 2:47,160,082...47,176,936
Ensembl chr 2:47,160,084...47,176,921
JBrowse link
G CAMP cathelicidin antimicrobial peptide multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CAMP mRNA
[Paraquat co-treated with Maneb] results in decreased expression of CAMP mRNA
CTD PMID:22563483 PMID:27460631 NCBI chr 3:48,223,495...48,225,485
Ensembl chr 3:48,223,347...48,225,491
JBrowse link
G CAPN11 calpain 11 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CAPN11 mRNA CTD PMID:22563483 NCBI chr 6:44,158,811...44,184,401
Ensembl chr 6:44,158,811...44,184,401
JBrowse link
G CASP1 caspase 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA; [Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA] CTD PMID:23963992 PMID:32375810 NCBI chr11:105,025,443...105,035,591
Ensembl chr11:105,025,443...105,035,250
JBrowse link
G CASP3 caspase 3 increases activity EXP Maneb results in increased activity of CASP3 protein CTD PMID:22824503 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP7 caspase 7 increases activity EXP Maneb results in increased activity of CASP7 protein CTD PMID:22824503 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP8 caspase 8 increases activity EXP Maneb results in increased activity of CASP8 protein CTD PMID:22824503 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 multiple interactions
increases activity
ISO
EXP
[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA; [Paraquat co-treated with Maneb] results in increased expression of CASP9 protein; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP9 protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP9 protein]
Maneb results in increased activity of CASP9 protein
CTD PMID:20964710 PMID:22824503 PMID:23963992 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase decreases activity
multiple interactions
ISO Maneb results in decreased activity of CAT protein
[Maneb co-treated with Paraquat] results in increased expression of CAT mRNA
CTD PMID:26210702 PMID:29859004 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CCDC88A coiled-coil domain containing 88A multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CCDC88A mRNA CTD PMID:22563483 NCBI chr 2:55,287,842...55,419,856
Ensembl chr 2:55,287,842...55,419,895
JBrowse link
G CCL19 C-C motif chemokine ligand 19 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CCL19 mRNA CTD PMID:22563483 NCBI chr 9:34,689,570...34,691,276
Ensembl chr 9:34,689,570...34,691,276
JBrowse link
G CCL21 C-C motif chemokine ligand 21 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CCL21 mRNA; [Paraquat co-treated with Maneb] affects the expression of CCL21A mRNA CTD PMID:22563483 NCBI chr 9:34,709,005...34,710,136
Ensembl chr 9:34,709,005...34,710,136
JBrowse link
G CCND1 cyclin D1 multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of CCND1 protein
[Maneb co-treated with Paraquat] results in decreased expression of CCND1 mRNA
CTD PMID:19883720 PMID:29859004 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CCND2 cyclin D2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of CCND2 mRNA CTD PMID:29859004 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353
JBrowse link
G CD34 CD34 molecule increases expression ISO Maneb results in increased expression of CD34 CTD PMID:25803990 NCBI chr 1:207,880,972...207,911,125
Ensembl chr 1:207,880,972...207,911,402
JBrowse link
G CD68 CD68 molecule multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of CD68 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CD68 mRNA] CTD PMID:32169474 NCBI chr17:7,579,638...7,582,111
Ensembl chr17:7,579,491...7,582,111
JBrowse link
G CDHR4 cadherin related family member 4 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CDHR4 mRNA CTD PMID:22563483 NCBI chr 3:49,790,732...49,802,741
Ensembl chr 3:49,790,732...49,799,873
JBrowse link
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CDIPT mRNA CTD PMID:18386188 NCBI chr16:29,858,357...29,863,226
Ensembl chr16:29,858,357...29,863,414
JBrowse link
G CDK2 cyclin dependent kinase 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA] CTD PMID:23963992 NCBI chr12:55,966,830...55,972,789
Ensembl chr12:55,966,781...55,972,789
JBrowse link
G CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5R1 mRNA CTD PMID:23017109 NCBI chr17:32,485,028...32,491,256
Ensembl chr17:32,486,993...32,491,253
JBrowse link
G CDK5RAP1 CDK5 regulatory subunit associated protein 1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5RAP1 mRNA CTD PMID:23017109 NCBI chr20:33,358,839...33,403,030
Ensembl chr20:33,358,839...33,401,561
JBrowse link
G CDK5RAP2 CDK5 regulatory subunit associated protein 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA; LRRK2 protein mutant form inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA]; SNCA protein inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA] CTD PMID:23017109 NCBI chr 9:120,388,875...120,580,167
Ensembl chr 9:120,388,875...120,580,170
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of CDKN1A mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDKN1A mRNA] CTD PMID:23963992 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A increases expression
multiple interactions
ISO Maneb results in increased expression of CDKN2A mRNA
[Maneb co-treated with Paraquat] results in increased expression of CDKN2A mRNA
CTD PMID:29859004 NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301
JBrowse link
G CEBPD CCAAT enhancer binding protein delta multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CEBPD mRNA CTD PMID:22563483 NCBI chr 8:47,736,913...47,738,164
Ensembl chr 8:47,736,913...47,738,164
JBrowse link
G CEP290 centrosomal protein 290 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CEP290 mRNA CTD PMID:22563483 NCBI chr12:88,049,013...88,142,216
Ensembl chr12:88,049,016...88,142,099
JBrowse link
G CHRM2 cholinergic receptor muscarinic 2 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CHRM2 mRNA CTD PMID:23017109 NCBI chr 7:136,868,652...137,020,213
Ensembl chr 7:136,868,652...137,020,255
JBrowse link
G CHUK component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO [Paraquat co-treated with Maneb] results in increased phosphorylation of CHUK protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of CHUK protein] CTD PMID:29568078 NCBI chr10:100,188,300...100,229,610
Ensembl chr10:100,188,300...100,229,596
JBrowse link
G CIRBP cold inducible RNA binding protein multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CIRBP mRNA CTD PMID:18386188 NCBI chr19:1,269,332...1,274,880
Ensembl chr19:1,259,384...1,274,880
JBrowse link
G CLCA1 chloride channel accessory 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of CLCA1 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CLCA1 mRNA] CTD PMID:23963992 NCBI chr 1:86,468,927...86,500,259
Ensembl chr 1:86,468,368...86,500,259
JBrowse link
G CLU clusterin multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CLU mRNA CTD PMID:18386188 NCBI chr 8:27,596,917...27,614,700
Ensembl chr 8:27,596,917...27,614,700
JBrowse link
G COPE COPI coat complex subunit epsilon multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of COPE mRNA CTD PMID:18386188 NCBI chr19:18,899,514...18,919,387
Ensembl chr19:18,899,514...18,919,387
JBrowse link
G COX5A cytochrome c oxidase subunit 5A multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of COX5A protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein] CTD PMID:23562983 NCBI chr15:74,919,791...74,938,073
Ensembl chr15:74,919,791...74,938,083
JBrowse link
G COX6A1 cytochrome c oxidase subunit 6A1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of COX6A1 mRNA CTD PMID:18386188 NCBI chr12:120,438,113...120,440,730
Ensembl chr12:120,438,090...120,440,737
JBrowse link
G COX6B1 cytochrome c oxidase subunit 6B1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA] CTD PMID:23963992 NCBI chr19:35,648,323...35,658,782
Ensembl chr19:35,648,323...35,658,782
JBrowse link
G COX7A2 cytochrome c oxidase subunit 7A2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of COX7A2 mRNA CTD PMID:18386188 NCBI chr 6:75,237,675...75,250,298
Ensembl chr 6:75,237,675...75,250,323
JBrowse link
G COX7A2L cytochrome c oxidase subunit 7A2 like multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of COX7A2L mRNA CTD PMID:18386188 NCBI chr 2:42,335,559...42,368,957
Ensembl chr 2:42,333,546...42,425,088
JBrowse link
G CPLX1 complexin 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CPLX1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of CPLX1 protein CTD PMID:17532186 NCBI chr 4:784,957...826,129
Ensembl chr 4:784,957...826,129
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]
[Paraquat co-treated with Maneb] results in decreased expression of and results in decreased phosphorylation of CREB1 protein; [Paraquat co-treated with Maneb] results in decreased expression of CREB1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of CREB1 protein; [Paraquat co-treated with Maneb] results in decreased expression of CREB1 protein modified form; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of and results in decreased phosphorylation of CREB1 protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of CREB1 mRNA]
CTD PMID:23963992 PMID:27460631 PMID:33368748 NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CRIP2 cysteine rich protein 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CRIP2 mRNA CTD PMID:18386188 NCBI chr14:105,472,945...105,480,170
Ensembl chr14:105,472,962...105,480,162
JBrowse link
G CRLF2 cytokine receptor like factor 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of CRLF2 mRNA CTD PMID:22563483 NCBI chr  Y:1,190,437...1,212,762
NCBI chr  X:1,190,437...1,212,762
Ensembl chr  X:1,187,549...1,212,723
JBrowse link
G CROT carnitine O-octanoyltransferase multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CROT mRNA CTD PMID:18386188 NCBI chr 7:87,345,646...87,399,794
Ensembl chr 7:87,345,664...87,399,794
JBrowse link
G CSF1R colony stimulating factor 1 receptor multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of CSF1R mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF1R mRNA] CTD PMID:32169474 NCBI chr 5:150,053,295...150,113,365
Ensembl chr 5:150,053,291...150,113,372
JBrowse link
G CSF2RA colony stimulating factor 2 receptor subunit alpha multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of CSF2RA mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF2RA mRNA] CTD PMID:32169474 NCBI chr  X:1,268,814...1,325,218
NCBI chr  Y:1,268,814...1,325,218
Ensembl chr  X:1,268,800...1,310,381
JBrowse link
G CTSL cathepsin L multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of CTSL mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CTSL mRNA] CTD PMID:23963992 NCBI chr 9:87,726,119...87,731,469
Ensembl chr 9:87,724,051...87,731,469
JBrowse link
G CYBB cytochrome b-245 beta chain multiple interactions EXP
ISO
[Paraquat co-treated with Maneb] results in increased expression of CYBB mRNA; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB mRNA]; diphenyleneiodonium inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB mRNA]
[Paraquat co-treated with Maneb] results in increased expression of CYBB protein; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein]
CTD PMID:29568078 PMID:30797899 PMID:32375810 NCBI chr  X:37,780,059...37,813,461
Ensembl chr  X:37,780,059...37,813,461
JBrowse link
G CYC1 cytochrome c1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of CYC1 mRNA CTD PMID:18386188 NCBI chr 8:144,095,076...144,097,525
Ensembl chr 8:144,095,039...144,097,525
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases activity
decreases expression
increases expression
ISO
EXP
Maneb results in increased activity of CYP1A1 protein
Maneb results in decreased expression of CYP1A1 mRNA
Maneb results in increased expression of CYP1A1 mRNA; Maneb results in increased expression of CYP1A1 protein
CTD PMID:20888808 PMID:32194361 NCBI chr15:74,719,542...74,725,528
Ensembl chr15:74,719,542...74,725,536
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein; [Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA] CTD PMID:23159886 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases expression EXP Maneb results in decreased expression of CYP2C19 protein CTD PMID:32194361 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 multiple interactions
decreases expression
ISO Ketoconazole inhibits the reaction [Maneb results in decreased expression of CYP2D22 protein] CTD PMID:22334051 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity
increases expression
multiple interactions
increases activity
ISO Maneb results in decreased activity of CYP2E1 protein
Maneb results in increased expression of CYP2E1 mRNA; Maneb results in increased expression of CYP2E1 protein
[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein; [Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA; Acetylcysteine inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA]; Maneb results in increased expression of and results in increased activity of CYP2E1 protein; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Silymarin inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA]
Maneb results in increased activity of CYP2E1 protein
[Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA; [Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein; [Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]
CTD PMID:11043497 PMID:16510128 PMID:20888808 PMID:20964710 PMID:23159886 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP Maneb results in decreased expression of CYP7A1 mRNA CTD PMID:32194361 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
JBrowse link
G DAP3 death associated protein 3 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of DAP3 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DAP3 mRNA] CTD PMID:23963992 NCBI chr 1:155,687,902...155,739,010
Ensembl chr 1:155,687,960...155,739,010
JBrowse link
G DBI diazepam binding inhibitor, acyl-CoA binding protein multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of DBI mRNA CTD PMID:18386188 NCBI chr 2:119,366,977...119,372,543
Ensembl chr 2:119,366,924...119,372,550
JBrowse link
G DDIT4 DNA damage inducible transcript 4 increases expression ISO Maneb results in increased expression of DDIT4 protein CTD PMID:24764117 NCBI chr10:72,273,924...72,276,036
Ensembl chr10:72,273,919...72,276,036
JBrowse link
G DDX5 DEAD-box helicase 5 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of DDX5 mRNA CTD PMID:18386188 NCBI chr17:64,498,254...64,506,866
Ensembl chr17:64,498,254...64,508,199
JBrowse link
G DGKI diacylglycerol kinase iota multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of DGKI mRNA CTD PMID:22563483 NCBI chr 7:137,381,037...137,846,974
Ensembl chr 7:137,381,037...137,847,092
JBrowse link
G DIO1 iodothyronine deiodinase 1 decreases activity EXP Maneb results in decreased activity of DIO1 protein CTD PMID:29228274 NCBI chr 1:53,894,187...53,911,086
Ensembl chr 1:53,891,239...53,911,086
JBrowse link
G DIP2B disco interacting protein 2 homolog B multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of DIP2B mRNA CTD PMID:22563483 NCBI chr12:50,504,985...50,748,657
Ensembl chr12:50,504,985...50,748,657
JBrowse link
G DLL1 delta like canonical Notch ligand 1 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DLL1 mRNA CTD PMID:23017109 NCBI chr 6:170,282,200...170,291,078
Ensembl chr 6:170,282,206...170,306,565
JBrowse link
G DLST dihydrolipoamide S-succinyltransferase multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of DLST protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein] CTD PMID:23562983 NCBI chr14:74,881,913...74,903,743
Ensembl chr14:74,881,891...74,903,743
JBrowse link
G DMRTA2 DMRT like family A2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of DMRTA2 mRNA CTD PMID:22563483 NCBI chr 1:50,417,550...50,423,443
Ensembl chr 1:50,417,550...50,423,443
JBrowse link
G DNAJB6 DnaJ heat shock protein family (Hsp40) member B6 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of DNAJB6 mRNA CTD PMID:18386188 NCBI chr 7:157,337,004...157,417,439
Ensembl chr 7:157,335,381...157,417,439
JBrowse link
G DNM2 dynamin 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of DNM2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of DNM2 mRNA] CTD PMID:23963992 NCBI chr19:10,718,079...10,831,903
Ensembl chr19:10,718,055...10,833,488
JBrowse link
G DRD2 dopamine receptor D2 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD2 mRNA CTD PMID:23017109 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G DRD4 dopamine receptor D4 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of DRD4 protein CTD PMID:22563483 NCBI chr11:637,269...640,706
Ensembl chr11:637,269...640,706
JBrowse link
G DRD5 dopamine receptor D5 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD5 mRNA CTD PMID:23017109 NCBI chr 4:9,781,634...9,784,009
Ensembl chr 4:9,781,634...9,784,009
JBrowse link
G E2F1 E2F transcription factor 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA] CTD PMID:23963992 NCBI chr20:33,675,477...33,686,385
Ensembl chr20:33,675,477...33,686,385
JBrowse link
G EEF1A1 eukaryotic translation elongation factor 1 alpha 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of EEF1A1 mRNA CTD PMID:18386188 NCBI chr 6:73,515,750...73,521,032
Ensembl chr 6:73,489,308...73,525,587
JBrowse link
G EEF1G eukaryotic translation elongation factor 1 gamma multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA] CTD PMID:23963992 NCBI chr11:62,559,596...62,573,891
Ensembl chr11:62,559,596...62,574,086
JBrowse link
G EFNB1 ephrin B1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of EFNB1 mRNA CTD PMID:23017109 NCBI chr  X:68,829,021...68,842,160
Ensembl chr  X:68,829,021...68,842,160
JBrowse link
G EGR4 early growth response 4 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of EGR4 mRNA CTD PMID:22563483 NCBI chr 2:73,290,929...73,293,548
Ensembl chr 2:73,290,929...73,293,701
JBrowse link
G EIF4G2 eukaryotic translation initiation factor 4 gamma 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA] CTD PMID:23963992 NCBI chr11:10,797,046...10,808,926
Ensembl chr11:10,797,050...10,808,940
JBrowse link
G ELK1 ETS transcription factor ELK1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ELK1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ELK1 mRNA] CTD PMID:23963992 NCBI chr  X:47,635,520...47,650,604
Ensembl chr  X:47,635,521...47,650,604
JBrowse link
G ENO1 enolase 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of ENO1 protein; [Paraquat co-treated with Maneb] results in decreased expression of ENO1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of ENO1 protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ENO1 protein] CTD PMID:17532186 PMID:18386188 PMID:23562983 NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190
JBrowse link
G ENO2 enolase 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of ENO2 protein CTD PMID:23562983 NCBI chr12:6,914,580...6,923,697
Ensembl chr12:6,913,745...6,923,698
JBrowse link
G FAS Fas cell surface death receptor multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of FAS mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA] CTD PMID:23963992 NCBI chr10:88,968,429...89,017,059
Ensembl chr10:88,953,813...89,029,605
JBrowse link
G FEZ1 fasciculation and elongation protein zeta 1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of FEZ1 mRNA CTD PMID:23017109 NCBI chr11:125,442,881...125,496,265
Ensembl chr11:125,442,881...125,592,568
JBrowse link
G FGFR3 fibroblast growth factor receptor 3 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of FGFR3 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FGFR3 mRNA] CTD PMID:23963992 NCBI chr 4:1,793,293...1,808,872
Ensembl chr 4:1,793,293...1,808,872
JBrowse link
G FKBP4 FKBP prolyl isomerase 4 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of FKBP4 mRNA CTD PMID:18386188 NCBI chr12:2,794,970...2,805,423
Ensembl chr12:2,794,970...2,805,423
JBrowse link
G FKBP5 FKBP prolyl isomerase 5 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of FKBP5 mRNA CTD PMID:18386188 NCBI chr 6:35,573,590...35,728,583
Ensembl chr 6:35,573,585...35,728,583
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of FOS mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FOS mRNA]
[Paraquat co-treated with Maneb] results in decreased expression of FOS mRNA; [Paraquat co-treated with Maneb] results in decreased expression of FOS protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of FOS mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of FOS protein]
CTD PMID:23963992 PMID:27460631 PMID:33368748 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FXYD6 FXYD domain containing ion transport regulator 6 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of FXYD6 mRNA CTD PMID:18386188 NCBI chr11:117,836,981...117,877,430
Ensembl chr11:117,836,976...117,877,486
JBrowse link
G G6PC1 glucose-6-phosphatase catalytic subunit 1 decreases expression EXP Maneb results in decreased expression of G6PC1 mRNA CTD PMID:32194361 NCBI chr17:42,900,799...42,914,438
Ensembl chr17:42,900,797...42,914,438
JBrowse link
G GABRA6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of GABRA6 mRNA CTD PMID:22563483 NCBI chr 5:161,685,721...161,702,592
Ensembl chr 5:161,547,063...161,702,593
JBrowse link
G GAS5 growth arrest specific 5 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of GAS5 mRNA CTD PMID:18386188 NCBI chr 1:173,863,899...173,868,882
Ensembl chr 1:173,858,559...173,868,882
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression
increases activity
EXP
ISO
[Maneb results in increased expression of NFE2L2 protein] which results in increased expression of GCLC mRNA
Maneb results in increased activity of GCLC protein
CTD PMID:15527874 PMID:21402726 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GFAP glial fibrillary acidic protein multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of GFAP protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of GFAP protein] CTD PMID:30797899 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GH1 growth hormone 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of GH mRNA CTD PMID:22563483 NCBI chr17:63,917,203...63,918,839
Ensembl chr17:63,917,200...63,918,839
JBrowse link
G GM2A GM2 ganglioside activator multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of GM2A mRNA CTD PMID:18386188 NCBI chr 5:151,253,185...151,270,440
Ensembl chr 5:151,212,150...151,270,440
JBrowse link
G GMFB glia maturation factor beta multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of GMFB mRNA; [Paraquat co-treated with Maneb] results in decreased expression of GMFB protein CTD PMID:17532186 NCBI chr14:54,474,485...54,488,980
Ensembl chr14:54,474,484...54,489,026
JBrowse link
G GNG5 G protein subunit gamma 5 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of GNG5 mRNA CTD PMID:18386188 NCBI chr 1:84,498,325...84,506,581
Ensembl chr 1:84,498,323...84,506,581
JBrowse link
G GNGT2 G protein subunit gamma transducin 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of GNGT2 mRNA CTD PMID:22563483 NCBI chr17:49,206,234...49,210,574
Ensembl chr17:49,202,791...49,210,574
JBrowse link
G GPR27 G protein-coupled receptor 27 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of GPR27 mRNA CTD PMID:22563483 NCBI chr 3:71,753,855...71,756,496
Ensembl chr 3:71,753,855...71,756,496
JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions
decreases expression
EXP
ISO
GPX1 protein results in decreased susceptibility to [Paraquat co-treated with Maneb]
[Maneb co-treated with Paraquat] results in increased expression of GPX1 mRNA
Maneb results in decreased expression of GPX1 mRNA
CTD PMID:15824117 PMID:26210702 PMID:29859004 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,353
JBrowse link
G GPX4 glutathione peroxidase 4 increases expression
multiple interactions
ISO
EXP
Maneb results in increased expression of GPX4 mRNA
[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein
[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein]; NFE2L2 gene mutant form inhibits the reaction [Maneb results in increased expression of GPX4 mRNA]
CTD PMID:23764462 PMID:30797899 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,994...1,106,791
JBrowse link
G GRB2 growth factor receptor bound protein 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA] CTD PMID:23963992 NCBI chr17:75,318,076...75,405,678
Ensembl chr17:75,318,076...75,405,709
JBrowse link
G GSK3B glycogen synthase kinase 3 beta multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein CTD PMID:19883720 NCBI chr 3:119,821,321...120,095,823
Ensembl chr 3:119,821,321...120,094,994
JBrowse link
G GSR glutathione-disulfide reductase multiple interactions ISO [Acetylcysteine co-treated with Paraquat co-treated with Maneb] results in increased activity of GSR protein; [Silymarin co-treated with Maneb] results in increased activity of GSR protein; [Silymarin co-treated with Paraquat co-treated with Maneb] results in increased activity of GSR protein
[NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased expression of GSR protein
CTD PMID:23159886 PMID:23764462 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSTA4 glutathione S-transferase alpha 4 multiple interactions
increases activity
increases expression
ISO [Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein; [Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA; Acetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]; Acetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]; Acetylcysteine promotes the reaction [Maneb results in increased expression of and results in increased activity of GSTA4 protein]; Acetylcysteine promotes the reaction [Maneb results in increased expression of GSTA4 mRNA]; Maneb results in increased expression of and results in increased activity of GSTA4 protein; Silymarin promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]; Silymarin promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]; Silymarin promotes the reaction [Maneb results in increased expression of and results in increased activity of GSTA4 protein]; Silymarin promotes the reaction [Maneb results in increased expression of GSTA4 mRNA]
Maneb results in increased activity of GSTA4 protein
Maneb results in increased expression of GSTA4 mRNA; Maneb results in increased expression of GSTA4 protein
CTD PMID:20888808 PMID:23159886 NCBI chr 6:52,977,952...52,995,332
Ensembl chr 6:52,977,948...52,995,304
JBrowse link
G GSTP1 glutathione S-transferase pi 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA] CTD PMID:23963992 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G GUK1 guanylate kinase 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of GUK1 mRNA CTD PMID:18386188 NCBI chr 1:228,140,084...228,148,955
Ensembl chr 1:228,139,962...228,148,984
JBrowse link
G H2AC15 H2A clustered histone 15 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of H2AC6 mRNA CTD PMID:22563483 NCBI chr 6:27,837,880...27,838,375
Ensembl chr 6:27,837,880...27,838,375
JBrowse link
G H2AC20 H2A clustered histone 20 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of H2AC20 mRNA CTD PMID:22563483 NCBI chr 1:149,886,918...149,887,411
Ensembl chr 1:149,886,918...149,887,411
JBrowse link
G HBA1 hemoglobin subunit alpha 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of HBA-A1 mRNA CTD PMID:18386188 NCBI chr16:176,680...177,522
Ensembl chr16:176,680...177,522
JBrowse link
G HDAC3 histone deacetylase 3 decreases activity EXP Maneb results in decreased activity of HDAC3 protein CTD PMID:21251949 NCBI chr 5:141,620,881...141,636,849
Ensembl chr 5:141,620,876...141,636,849
JBrowse link
G HDAC6 histone deacetylase 6 decreases activity EXP Maneb results in decreased activity of HDAC6 protein CTD PMID:21251949 NCBI chr  X:48,801,398...48,824,982
Ensembl chr  X:48,801,377...48,824,982
JBrowse link
G HES3 hes family bHLH transcription factor 3 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of HES3 mRNA CTD PMID:22563483 NCBI chr 1:6,244,179...6,245,578
Ensembl chr 1:6,244,179...6,245,578
JBrowse link
G HEY2 hes related family bHLH transcription factor with YRPW motif 2 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEY2 mRNA CTD PMID:23017109 NCBI chr 6:125,747,639...125,762,243
Ensembl chr 6:125,747,664...125,761,269
JBrowse link
G HEYL hes related family bHLH transcription factor with YRPW motif like multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEYL mRNA CTD PMID:23017109 NCBI chr 1:39,623,435...39,639,643
Ensembl chr 1:39,623,435...39,639,643
JBrowse link
G HK1 hexokinase 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of HK1 mRNA CTD PMID:18386188 NCBI chr10:69,269,991...69,401,882
Ensembl chr10:69,269,984...69,401,884
JBrowse link
G HMGA2 high mobility group AT-hook 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of HMGA2 mRNA CTD PMID:18386188 NCBI chr12:65,824,460...65,966,291
Ensembl chr12:65,824,460...65,966,291
JBrowse link
G HMGN5 high mobility group nucleosome binding domain 5 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of HMGN5 mRNA CTD PMID:22563483 NCBI chr  X:81,113,699...81,201,913
Ensembl chr  X:81,113,699...81,201,913
JBrowse link
G HMOX1 heme oxygenase 1 increases expression
multiple interactions
ISO Maneb results in increased expression of HMOX1 protein
[NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased expression of HMOX1 protein
CTD PMID:15527874 PMID:23764462 NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214
JBrowse link
G HNRNPK heterogeneous nuclear ribonucleoprotein K multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of HNRNPK mRNA CTD PMID:18386188 NCBI chr 9:83,968,083...83,980,630
Ensembl chr 9:83,968,083...83,980,616
JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity EXP Maneb results in decreased activity of HSD11B2 protein CTD PMID:22796344 NCBI chr16:67,431,121...67,437,553
Ensembl chr16:67,430,652...67,437,553
JBrowse link
G HSF1 heat shock transcription factor 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA] CTD PMID:23963992 NCBI chr 8:144,291,603...144,314,720
Ensembl chr 8:144,291,591...144,314,720
JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA; [Paraquat co-treated with Maneb] results in increased expression of HSP90AA1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA] CTD PMID:18386188 PMID:23963992 NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699
JBrowse link
G HSPA1B heat shock protein family A (Hsp70) member 1B multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of HSPA1B mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSPA1B mRNA] CTD PMID:23963992 NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of HSPA5 mRNA CTD PMID:18386188 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382
JBrowse link
G HSPA8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of HSPA8 mRNA CTD PMID:18386188 NCBI chr11:123,057,489...123,062,366
Ensembl chr11:123,057,489...123,063,230
JBrowse link
G ICAM1 intercellular adhesion molecule 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of ICAM1 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ICAM1 mRNA] CTD PMID:32169474 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615
JBrowse link
G ICAM2 intercellular adhesion molecule 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of ICAM2 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ICAM2 mRNA] CTD PMID:32169474 NCBI chr17:64,002,595...64,020,633
Ensembl chr17:64,002,594...64,020,634
JBrowse link
G IDH3A isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of IDH3A protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IDH3A protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IDH3A protein] CTD PMID:23562983 NCBI chr15:78,149,362...78,171,945
Ensembl chr15:78,131,498...78,171,945
JBrowse link
G IER5L immediate early response 5 like multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of IER5L mRNA CTD PMID:22563483 NCBI chr 9:129,175,552...129,178,261
Ensembl chr 9:129,175,552...129,178,261
JBrowse link
G IFNG interferon gamma multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of IFNG mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IFNG mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IFNG mRNA] CTD PMID:23963992 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IGF1 insulin like growth factor 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA] CTD PMID:23963992 NCBI chr12:102,395,860...102,481,839
Ensembl chr12:102,395,874...102,481,744
JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; Silymarin inhibits the reaction [Maneb results in increased expression of IL1B mRNA]
[Maneb co-treated with Paraquat] results in increased expression of IL1B mRNA; [Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA; [Paraquat co-treated with Maneb] results in increased expression of IL1B protein; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B mRNA]; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]
CTD PMID:23159886 PMID:23963992 PMID:29568078 PMID:32169474 PMID:32375810 NCBI chr 2:112,829,751...112,836,843
Ensembl chr 2:112,829,751...112,836,816
JBrowse link
G IL6 interleukin 6 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of IL6 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL6 mRNA] CTD PMID:32169474 NCBI chr 7:22,725,889...22,732,002
Ensembl chr 7:22,725,884...22,732,002
JBrowse link
G INHBA inhibin subunit beta A multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of INHBA mRNA; [Paraquat co-treated with Maneb] affects the expression of INHBA mRNA CTD PMID:22563483 PMID:23017109 NCBI chr 7:41,685,101...41,710,532
Ensembl chr 7:41,667,168...41,705,834
JBrowse link
G IRS2 insulin receptor substrate 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA] CTD PMID:23963992 NCBI chr13:109,752,695...109,786,583
Ensembl chr13:109,752,695...109,786,583
JBrowse link
G ITGAM integrin subunit alpha M multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of ITGAM protein; [Paraquat co-treated with Maneb] results in increased expression of ITGAM mRNA; [Paraquat co-treated with Maneb] results in increased expression of ITGAM protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ITGAM protein]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ITGAM protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ITGAM mRNA] CTD PMID:28202386 PMID:30797899 PMID:32169474 PMID:32375810 NCBI chr16:31,259,975...31,332,877
Ensembl chr16:31,259,967...31,332,892
JBrowse link
G ITGB8 integrin subunit beta 8 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ITGB8 mRNA CTD PMID:22563483 NCBI chr 7:20,329,819...20,415,754
Ensembl chr 7:20,330,702...20,415,754
JBrowse link
G ITPR1 inositol 1,4,5-trisphosphate receptor type 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA] CTD PMID:23963992 NCBI chr 3:4,493,348...4,847,506
Ensembl chr 3:4,493,345...4,847,506
JBrowse link
G JPT1 Jupiter microtubule associated homolog 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of JPT1 mRNA CTD PMID:18386188 NCBI chr17:75,135,243...75,154,512
Ensembl chr17:75,135,248...75,168,281
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of JUN mRNA; [Paraquat co-treated with Maneb] results in decreased expression of JUN protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of JUN mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of JUN protein] CTD PMID:27460631 PMID:33368748 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G KCNA2 potassium voltage-gated channel subfamily A member 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of KCNA2 mRNA CTD PMID:22563483 NCBI chr 1:110,593,580...110,631,536
Ensembl chr 1:110,519,837...110,631,474
JBrowse link
G KCNMA1 potassium calcium-activated channel subfamily M alpha 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of KCNMA1 mRNA CTD PMID:22563483 NCBI chr10:76,869,602...77,637,969
Ensembl chr10:76,869,601...77,638,369
JBrowse link
G KIAA1217 KIAA1217 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ETL4 mRNA CTD PMID:22563483 NCBI chr10:23,694,727...24,547,843
Ensembl chr10:23,694,746...24,547,848
JBrowse link
G KIF1B kinesin family member 1B multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of KIF1B mRNA CTD PMID:22563483 NCBI chr 1:10,210,570...10,381,603
Ensembl chr 1:10,210,570...10,381,603
JBrowse link
G KIT KIT proto-oncogene, receptor tyrosine kinase decreases expression ISO Maneb results in decreased expression of KIT CTD PMID:25803990 NCBI chr 4:54,657,957...54,740,715
Ensembl chr 4:54,657,267...54,740,783
JBrowse link
G KLF2 Kruppel like factor 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of KLF2 mRNA CTD PMID:22563483 NCBI chr19:16,324,826...16,328,685
Ensembl chr19:16,324,826...16,328,685
JBrowse link
G KLHL15 kelch like family member 15 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of KLHL15 mRNA CTD PMID:22563483 NCBI chr  X:23,983,720...24,027,186
Ensembl chr  X:23,983,716...24,027,186
JBrowse link
G LAMC2 laminin subunit gamma 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of LAMC2 mRNA CTD PMID:22563483 NCBI chr 1:183,186,264...183,245,127
Ensembl chr 1:183,186,238...183,245,127
JBrowse link
G LIFR LIF receptor subunit alpha multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of LIFR mRNA CTD PMID:22563483 NCBI chr 5:38,474,668...38,606,290
Ensembl chr 5:38,474,668...38,608,354
JBrowse link
G LIMK2 LIM domain kinase 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of LIMK2 mRNA CTD PMID:18386188 NCBI chr22:31,212,298...31,280,080
Ensembl chr22:31,212,239...31,280,080
JBrowse link
G LORICRIN loricrin cornified envelope precursor protein multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of LOR mRNA CTD PMID:22563483 NCBI chr 1:153,259,635...153,262,125
Ensembl chr 1:153,259,687...153,262,124
JBrowse link
G LRP4 LDL receptor related protein 4 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of LRP4 mRNA CTD PMID:22563483 NCBI chr11:46,854,715...46,918,550
Ensembl chr11:46,856,717...46,918,642
JBrowse link
G LRRC17 leucine rich repeat containing 17 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of LRRC17 mRNA CTD PMID:18386188 NCBI chr 7:102,913,000...102,945,111
Ensembl chr 7:102,913,000...102,945,111
JBrowse link
G LRRC41 leucine rich repeat containing 41 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of LRRC41 mRNA CTD PMID:18386188 NCBI chr 1:46,277,462...46,303,616
Ensembl chr 1:46,261,196...46,303,616
JBrowse link
G LRRK2 leucine rich repeat kinase 2 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of ACHE mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5R1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5RAP1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CHRM2 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of EFNB1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of FEZ1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEY2 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NDP mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NRG1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX6 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of POU3F3 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA; LRRK2 protein mutant form inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA] CTD PMID:23017109 NCBI chr12:40,224,890...40,369,285
Ensembl chr12:40,196,744...40,369,285
JBrowse link
G LYNX1 Ly6/neurotoxin 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of LYNX1 mRNA CTD PMID:18386188 NCBI chr 8:142,771,197...142,777,872
Ensembl chr 8:142,771,197...142,777,810
JBrowse link
G MACF1 microtubule actin crosslinking factor 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of MACF1 mRNA CTD PMID:18386188 NCBI chr 1:39,084,167...39,487,138
Ensembl chr 1:39,081,316...39,487,177
JBrowse link
G MAP2 microtubule associated protein 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA] CTD PMID:23963992 NCBI chr 2:209,424,047...209,734,118
Ensembl chr 2:209,424,047...209,734,118
JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA] CTD PMID:23963992 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656
JBrowse link
G MAP2K6 mitogen-activated protein kinase kinase 6 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of MAP2K6 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of MAP2K6 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of MAP2K6 mRNA] CTD PMID:23963992 NCBI chr17:69,414,697...69,553,865
Ensembl chr17:69,414,697...69,553,865
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP
ISO
[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK1 protein
[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK1 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK1 protein]
CTD PMID:15824117 PMID:30797899 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680
JBrowse link
G MAPK15 mitogen-activated protein kinase 15 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of MAPK15 mRNA CTD PMID:22563483 NCBI chr 8:143,716,305...143,722,458
Ensembl chr 8:143,716,340...143,722,458
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP
ISO
[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK3 protein
[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK3 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK3 protein]
CTD PMID:15824117 PMID:30797899 NCBI chr16:30,114,105...30,123,309
Ensembl chr16:30,114,105...30,123,506
JBrowse link
G MAPT microtubule associated protein tau multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA] CTD PMID:23963992 NCBI chr17:45,894,538...46,028,334
Ensembl chr17:45,894,527...46,028,334
JBrowse link
G MARCHF9 membrane associated ring-CH-type finger 9 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of MARCHF9 mRNA CTD PMID:22563483 NCBI chr12:57,755,103...57,760,411
Ensembl chr12:57,755,103...57,760,411
JBrowse link
G MBD3 methyl-CpG binding domain protein 3 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of MBD3 mRNA; [Paraquat co-treated with Maneb] results in increased expression of MBD3 mRNA CTD PMID:18386188 NCBI chr19:1,573,596...1,592,865
Ensembl chr19:1,573,596...1,592,865
JBrowse link
G MBNL1 muscleblind like splicing regulator 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of MBNL1 mRNA CTD PMID:18386188 NCBI chr 3:152,243,632...152,465,780
Ensembl chr 3:152,243,828...152,465,780
JBrowse link
G MBOAT2 membrane bound O-acyltransferase domain containing 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of MBOAT2 mRNA CTD PMID:22563483 NCBI chr 2:8,852,690...9,003,684
Ensembl chr 2:8,852,690...9,003,709
JBrowse link
G MCL1 MCL1 apoptosis regulator, BCL2 family member increases expression
multiple interactions
EXP Maneb results in increased expression of MCL1 protein
[Paraquat co-treated with Maneb] results in increased expression of MCL1 protein
CTD PMID:18266926 NCBI chr 1:150,574,558...150,579,610
Ensembl chr 1:150,560,895...150,579,738
JBrowse link
G MDM4 MDM4 regulator of p53 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of MDM4 mRNA CTD PMID:18386188 NCBI chr 1:204,516,377...204,558,120
Ensembl chr 1:204,516,379...204,558,120
JBrowse link
G MEF2C myocyte enhancer factor 2C multiple interactions EXP [Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased metabolism of MEF2C protein; [Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased metabolism of MEF2C protein CTD PMID:24290359 NCBI chr 5:88,717,117...88,904,105
Ensembl chr 5:88,717,117...88,904,257
JBrowse link
G MFGE8 milk fat globule EGF and factor V/VIII domain containing multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of MFGE8 mRNA CTD PMID:18386188 NCBI chr15:88,898,683...88,913,405
Ensembl chr15:88,898,683...88,913,381
JBrowse link
G MRC1 mannose receptor C-type 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of MRC1 mRNA CTD PMID:29568078 NCBI chr10:17,809,348...17,911,164
Ensembl chr10:17,809,348...17,911,164
JBrowse link
G MRPL15 mitochondrial ribosomal protein L15 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of MRPL15 mRNA CTD PMID:18386188 NCBI chr 8:54,135,224...54,148,514
Ensembl chr 8:54,135,241...54,148,514
JBrowse link
G MRTFB myocardin related transcription factor B multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of MRTFB mRNA CTD PMID:22563483 NCBI chr16:14,071,062...14,266,779
Ensembl chr16:14,071,319...14,266,773
JBrowse link
G MT1X metallothionein 1X multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of MT1 mRNA CTD PMID:18386188 NCBI chr16:56,682,470...56,684,196
Ensembl chr16:56,682,470...56,684,196
JBrowse link
G MTHFR methylenetetrahydrofolate reductase multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of MTHFR mRNA CTD PMID:18386188 NCBI chr 1:11,785,723...11,806,103
Ensembl chr 1:11,785,723...11,806,455
JBrowse link
G MTOR mechanistic target of rapamycin kinase multiple interactions
increases expression
ISO [Paraquat co-treated with Maneb] results in increased expression of MTOR protein; Maneb promotes the reaction [Paraquat results in increased expression of MTOR protein]; Paraquat promotes the reaction [Maneb results in increased expression of MTOR protein] CTD PMID:22292029 PMID:26884967 NCBI chr 1:11,106,535...11,273,497
Ensembl chr 1:11,106,535...11,262,551
JBrowse link
G MUC6 mucin 6, oligomeric mucus/gel-forming multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of MUC6 mRNA CTD PMID:22563483 NCBI chr11:1,012,823...1,036,718
Ensembl chr11:1,012,823...1,036,718
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of MYC protein CTD PMID:19883720 NCBI chr 8:127,735,434...127,742,951
Ensembl chr 8:127,735,434...127,742,951
JBrowse link
G NCF1 neutrophil cytosolic factor 1 multiple interactions ISO [Maneb co-treated with Paraquat] affects the localization of NCF1 protein; [Paraquat co-treated with Maneb] results in increased expression of NCF1 protein; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NCF1 protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] affects the localization of NCF1 protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NCF1 protein] CTD PMID:28202386 PMID:29568078 PMID:32375810 NCBI chr 7:74,774,011...74,789,315
Ensembl chr 7:74,774,011...74,789,315
JBrowse link
G NDP norrin cystine knot growth factor NDP multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NDP mRNA CTD PMID:23017109 NCBI chr  X:43,948,776...43,973,390
Ensembl chr  X:43,948,776...43,973,395
JBrowse link
G NEUROD1 neuronal differentiation 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of NEUROD1 mRNA CTD PMID:23017109 NCBI chr 2:181,668,295...181,680,517
Ensembl chr 2:181,668,295...181,680,827
JBrowse link
G NFAT5 nuclear factor of activated T cells 5 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of NFAT5 mRNA CTD PMID:22563483 NCBI chr16:69,565,952...69,704,654
Ensembl chr16:69,565,094...69,704,666
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 increases expression
increases response to substance
multiple interactions
EXP
ISO
[Maneb results in increased expression of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of PRDX1 mRNA; [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of TXN1 mRNA; [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA; Maneb results in increased expression of NFE2L2 protein
NFE2L2 gene mutant form results in increased susceptibility to Maneb
[NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased abundance of Glutathione; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased expression of GSR protein; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased expression of HMOX1 protein; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in increased abundance of Manganese; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in increased abundance of Thiobarbituric Acid Reactive Substances; NFE2L2 gene mutant form inhibits the reaction [Maneb results in increased expression of GPX4 mRNA]
CTD PMID:21402726 PMID:23764462 NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
G NFIB nuclear factor I B multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of NFIB mRNA CTD PMID:22563483 NCBI chr 9:14,081,843...14,532,077
Ensembl chr 9:14,081,843...14,398,983
JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of NFKB1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NFKB1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NFKB1 mRNA] CTD PMID:23963992 NCBI chr 4:102,501,266...102,617,302
Ensembl chr 4:102,501,331...102,617,302
JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions ISO [Maneb co-treated with Paraquat] results in increased phosphorylation of and results in decreased expression of NFKBIA protein; [Paraquat co-treated with Maneb] results in increased degradation of and results in increased phosphorylation of NFKBIA protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of and results in decreased expression of NFKBIA protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased degradation of and results in increased phosphorylation of NFKBIA protein] CTD PMID:28202386 PMID:29568078 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,513...35,404,749
JBrowse link
G NIPBL NIPBL cohesin loading factor multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of NIPBL mRNA CTD PMID:22563483 NCBI chr 5:36,876,769...37,066,413
Ensembl chr 5:36,876,769...37,066,413
JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein] CTD PMID:32375810 NCBI chr 1:247,416,163...247,448,823
Ensembl chr 1:247,416,156...247,449,108
JBrowse link
G NOG noggin multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of NOG mRNA CTD PMID:23017109 NCBI chr17:56,593,699...56,595,611
Ensembl chr17:56,593,699...56,595,611
JBrowse link
G NOS2 nitric oxide synthase 2 multiple interactions
increases expression
ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; [Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA; [Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA; [Paraquat co-treated with Maneb] results in increased expression of NOS2 protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Genistein inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; prolinedithiocarbamate inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]
[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Silymarin inhibits the reaction [Maneb results in increased expression of NOS2 mRNA]
CTD PMID:20455021 PMID:23159886 PMID:23963992 PMID:28202386 PMID:29568078 More... NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529
JBrowse link
G NOX1 NADPH oxidase 1 multiple interactions EXP [Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA]; diphenyleneiodonium inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA] CTD PMID:30797899 NCBI chr  X:100,843,324...100,874,359
Ensembl chr  X:100,843,324...100,874,359
JBrowse link
G NPS neuropeptide S multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of NPS mRNA CTD PMID:22563483 NCBI chr10:127,549,309...127,553,540
Ensembl chr10:127,549,309...127,553,540
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression EXP [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of NQO1 mRNA CTD PMID:21402726 NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668
JBrowse link
G NR4A1 nuclear receptor subfamily 4 group A member 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of NR4A1 mRNA CTD PMID:22563483 NCBI chr12:52,022,832...52,059,507
Ensembl chr12:52,022,832...52,059,507
JBrowse link
G NR4A2 nuclear receptor subfamily 4 group A member 2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of NR4A2 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of NR4A2 protein CTD PMID:29152652 NCBI chr 2:156,324,432...156,332,724
Ensembl chr 2:156,324,437...156,342,348
JBrowse link
G NRG1 neuregulin 1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NRG1 mRNA CTD PMID:23017109 NCBI chr 8:31,639,245...32,774,046
Ensembl chr 8:31,639,222...32,855,666
JBrowse link
G NRTN neurturin multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of NRTN mRNA CTD PMID:22563483 NCBI chr19:5,805,067...5,828,324
Ensembl chr19:5,805,067...5,828,324
JBrowse link
G NTN1 netrin 1 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA; [Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA CTD PMID:23017109 NCBI chr17:9,021,510...9,244,000
Ensembl chr17:9,021,510...9,244,000
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA] CTD PMID:23963992 NCBI chr 9:84,668,458...85,027,070
Ensembl chr 9:84,668,375...85,095,751
JBrowse link
G OAZ2 ornithine decarboxylase antizyme 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of OAZ2 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of OAZ2 mRNA] CTD PMID:23963992 NCBI chr15:64,687,574...64,703,281
Ensembl chr15:64,687,573...64,703,281
JBrowse link
G P2RY4 pyrimidinergic receptor P2Y4 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA] CTD PMID:23963992 NCBI chr  X:70,258,166...70,260,204
Ensembl chr  X:70,258,166...70,260,204
JBrowse link
G PAX5 paired box 5 multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX5 mRNA CTD PMID:23017109 NCBI chr 9:36,833,269...37,034,268
Ensembl chr 9:36,833,269...37,034,268
JBrowse link
G PAX6 paired box 6 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX6 mRNA CTD PMID:23017109 NCBI chr11:31,789,026...31,817,961
Ensembl chr11:31,784,779...31,817,961
JBrowse link
G PCDH7 protocadherin 7 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of PCDH7 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PCDH7 mRNA] CTD PMID:23963992 NCBI chr 4:30,720,369...31,146,800
Ensembl chr 4:30,720,415...31,146,805
JBrowse link
G PCNA proliferating cell nuclear antigen multiple interactions ISO 3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of PCNA protein]; [Paraquat co-treated with Maneb] results in decreased expression of PCNA protein CTD PMID:23985028 NCBI chr20:5,114,953...5,126,622
Ensembl chr20:5,114,953...5,126,626
JBrowse link
G PCP2 Purkinje cell protein 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of PCP2 mRNA CTD PMID:22563483 NCBI chr19:7,631,614...7,637,026
Ensembl chr19:7,631,611...7,633,719
JBrowse link
G PDCD10 programmed cell death 10 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of PDCD10 mRNA CTD PMID:18386188 NCBI chr 3:167,683,298...167,735,810
Ensembl chr 3:167,683,298...167,734,939
JBrowse link
G PDE1B phosphodiesterase 1B multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of PDE1B mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PDE1B mRNA] CTD PMID:23963992 NCBI chr12:54,549,601...54,579,239
Ensembl chr12:54,549,601...54,579,239
JBrowse link
G PDGFRA platelet derived growth factor receptor alpha multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA] CTD PMID:23963992 NCBI chr 4:54,229,127...54,298,245
Ensembl chr 4:54,229,280...54,298,245
JBrowse link
G PDHA1 pyruvate dehydrogenase E1 subunit alpha 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of PDHA1 mRNA; [Maneb co-treated with Paraquat] results in increased expression of PDHA1 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PDHA1 protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PDHA1 mRNA] CTD PMID:23562983 PMID:23963992 NCBI chr  X:19,343,906...19,361,718
Ensembl chr  X:19,343,893...19,361,718
JBrowse link
G PDYN prodynorphin multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of PDYN CTD PMID:24376148 NCBI chr20:1,978,756...1,994,285
Ensembl chr20:1,978,757...1,994,285
JBrowse link
G PEBP1 phosphatidylethanolamine binding protein 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of PEBP1 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PEBP1 protein] CTD PMID:23562983 NCBI chr12:118,136,124...118,145,584
Ensembl chr12:118,136,124...118,145,584
JBrowse link
G PGS1 phosphatidylglycerophosphate synthase 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of PGS1 mRNA CTD PMID:18386188 NCBI chr17:78,378,623...78,424,659
Ensembl chr17:78,378,649...78,425,114
JBrowse link
G PIGC phosphatidylinositol glycan anchor biosynthesis class C multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of PIGC mRNA CTD PMID:18386188 NCBI chr 1:172,441,457...172,444,069
Ensembl chr 1:172,370,189...172,444,086
JBrowse link
G PLCE1 phospholipase C epsilon 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of PLCE1 mRNA CTD PMID:22563483 NCBI chr10:93,993,931...94,332,823
Ensembl chr10:93,993,931...94,332,823
JBrowse link
G PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 increases expression EXP Maneb results in increased expression of PMAIP1 mRNA; Maneb results in increased expression of PMAIP1 protein CTD PMID:18266926 NCBI chr18:59,899,996...59,904,305
Ensembl chr18:59,899,996...59,904,305
JBrowse link
G PNOC prepronociceptin multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of PNOC CTD PMID:24376148 NCBI chr 8:28,316,979...28,343,355
Ensembl chr 8:28,316,986...28,343,355
JBrowse link
G POLR1C RNA polymerase I and III subunit C multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of POLR1C mRNA CTD PMID:18386188 NCBI chr 6:43,517,089...44,461,400
Ensembl chr 6:43,509,702...43,562,419
JBrowse link
G POLR2K RNA polymerase II, I and III subunit K multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of POLR2K mRNA CTD PMID:22563483 NCBI chr 8:100,150,636...100,154,003
Ensembl chr 8:100,150,623...100,154,003
JBrowse link
G POU3F3 POU class 3 homeobox 3 multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of POU3F3 mRNA CTD PMID:23017109 NCBI chr 2:104,854,115...104,858,574
Ensembl chr 2:104,853,287...104,858,574
JBrowse link
G PRDX1 peroxiredoxin 1 increases expression EXP [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of PRDX1 mRNA CTD PMID:21402726 NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,510,914...45,542,732
JBrowse link
G PRDX3 peroxiredoxin 3 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein] CTD PMID:23562983 NCBI chr10:119,167,720...119,178,812
Ensembl chr10:119,167,720...119,178,812
JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of PRKACA mRNA; [Paraquat co-treated with Maneb] results in decreased expression of PRKACA protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of PRKACA mRNA] CTD PMID:27460631 PMID:33368748 NCBI chr19:14,091,688...14,117,762
Ensembl chr19:14,091,688...14,118,084
JBrowse link
G PRKCZ protein kinase C zeta multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of PRKCZ mRNA CTD PMID:18386188 NCBI chr 1:2,050,411...2,185,395
Ensembl chr 1:2,050,411...2,185,395
JBrowse link
G PRKN parkin RBR E3 ubiquitin protein ligase multiple interactions ISO 3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased nitrosation of PRKN protein]; [Paraquat co-treated with Maneb] results in increased expression of PRKN protein; [Paraquat co-treated with Maneb] results in increased nitrosation of PRKN protein CTD PMID:22563483 PMID:23985028 NCBI chr 6:161,347,417...162,727,802
Ensembl chr 6:161,347,417...162,727,775
JBrowse link
G PRL prolactin multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of PRL mRNA CTD PMID:22563483 NCBI chr 6:22,287,246...22,302,897
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G PRR7 proline rich 7, synaptic multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of PRR7 mRNA CTD PMID:22563483 NCBI chr 5:177,445,995...177,456,286
Ensembl chr 5:177,446,445...177,456,286
JBrowse link
G PSAP prosaposin multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of PSAP mRNA CTD PMID:18386188 NCBI chr10:71,816,298...71,851,251
Ensembl chr10:71,816,298...71,851,251
JBrowse link
G PSEN1 presenilin 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of PSEN1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PSEN1 mRNA] CTD PMID:23963992 NCBI chr14:73,136,436...73,223,691
Ensembl chr14:73,136,418...73,223,691
JBrowse link
G PSMB1 proteasome 20S subunit beta 1 multiple interactions EXP Maneb inhibits the reaction [Paraquat results in decreased expression of PSMB1 mRNA] CTD PMID:26498265 NCBI chr 6:170,535,120...170,553,307
Ensembl chr 6:170,535,120...170,553,307
JBrowse link
G PSMC4 proteasome 26S subunit, ATPase 4 multiple interactions ISO
EXP
[Maneb co-treated with Paraquat] results in decreased expression of PSMC4 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PSMC4 mRNA]
[Paraquat co-treated with Maneb] results in decreased expression of PSMC4 mRNA
CTD PMID:23963992 PMID:26498265 NCBI chr19:39,971,150...39,981,764
Ensembl chr19:39,971,165...39,981,764
JBrowse link
G PTK2B protein tyrosine kinase 2 beta multiple interactions ISO [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form CTD PMID:19883720 NCBI chr 8:27,311,478...27,459,391
Ensembl chr 8:27,311,482...27,459,391
JBrowse link
G PTPN4 protein tyrosine phosphatase non-receptor type 4 affects activity EXP Maneb affects the activity of PTPN4 protein CTD PMID:23611293 NCBI chr 2:119,759,922...119,984,899
Ensembl chr 2:119,759,922...119,984,899
JBrowse link
G PTPN9 protein tyrosine phosphatase non-receptor type 9 affects activity EXP Maneb affects the activity of PTPN9 protein CTD PMID:23611293 NCBI chr15:75,463,251...75,579,315
Ensembl chr15:75,463,251...75,579,315
JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of RAF1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RAF1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RAF1 mRNA] CTD PMID:23963992 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201
JBrowse link
G RB1 RB transcriptional corepressor 1 multiple interactions
increases expression
ISO [Maneb co-treated with Paraquat] results in increased expression of RB1 mRNA; Acetylcysteine inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of RB1 mRNA]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of RB1 mRNA] CTD PMID:29859004 NCBI chr13:48,303,751...48,481,890
Ensembl chr13:48,303,744...48,599,436
JBrowse link
G RBX1 ring-box 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of RBX1 mRNA CTD PMID:18386188 NCBI chr22:40,951,378...40,973,309
Ensembl chr22:40,951,347...40,973,309
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Maneb co-treated with Paraquat] results in increased phosphorylation of RELA protein; [Paraquat co-treated with Maneb] results in increased phosphorylation of RELA protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of RELA protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of RELA protein] CTD PMID:28202386 PMID:29568078 NCBI chr11:65,653,601...65,662,946
Ensembl chr11:65,653,599...65,663,090
JBrowse link
G RIPK1 receptor interacting serine/threonine kinase 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of RIPK1 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of RIPK1 mRNA] CTD PMID:23963992 NCBI chr 6:3,063,967...3,115,187
Ensembl chr 6:3,063,824...3,115,187
JBrowse link
G ROCK1 Rho associated coiled-coil containing protein kinase 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ROCK1 mRNA CTD PMID:22563483 NCBI chr18:20,946,906...21,111,813
Ensembl chr18:20,946,906...21,111,813
JBrowse link
G RPL12 ribosomal protein L12 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of RPL12 mRNA CTD PMID:18386188 NCBI chr 9:127,447,674...127,451,406
Ensembl chr 9:127,447,674...127,451,406
JBrowse link
G RPL19 ribosomal protein L19 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of RPL19 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RPL19 mRNA] CTD PMID:23963992 NCBI chr17:39,200,283...39,204,732
Ensembl chr17:39,200,283...39,204,840
JBrowse link
G RPL41 ribosomal protein L41 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of RPL41 mRNA CTD PMID:18386188 NCBI chr12:56,116,633...56,117,967
Ensembl chr12:56,116,590...56,117,967
JBrowse link
G RPL8 ribosomal protein L8 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of RPL8 mRNA CTD PMID:18386188 NCBI chr 8:144,789,769...144,792,390
Ensembl chr 8:144,789,765...144,792,587
JBrowse link
G RPL9 ribosomal protein L9 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of RPL9 mRNA CTD PMID:18386188 NCBI chr 4:39,454,124...39,458,922
Ensembl chr 4:39,452,587...39,458,931
JBrowse link
G RPS12 ribosomal protein S12 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of RPS12 mRNA CTD PMID:18386188 NCBI chr 6:132,814,569...132,817,564
Ensembl chr 6:132,814,569...132,817,564
JBrowse link
G RPS15 ribosomal protein S15 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of RPS15 mRNA CTD PMID:18386188 NCBI chr19:1,438,396...1,440,495
Ensembl chr19:1,438,358...1,440,495
JBrowse link
G RPS27 ribosomal protein S27 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of RPS27 mRNA CTD PMID:18386188 NCBI chr 1:153,990,762...153,992,155
Ensembl chr 1:153,990,762...153,992,155
JBrowse link
G RPS6KA2 ribosomal protein S6 kinase A2 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of RPS6KA2 mRNA CTD PMID:18386188 NCBI chr 6:166,409,364...166,862,525
Ensembl chr 6:166,409,364...166,906,451
JBrowse link
G RTN4 reticulon 4 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of RTN4 mRNA CTD PMID:23017109 NCBI chr 2:54,972,189...55,137,831
Ensembl chr 2:54,972,187...55,112,621
JBrowse link
G RTN4RL2 reticulon 4 receptor like 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of RTN4RL2 mRNA CTD PMID:22563483 NCBI chr11:57,460,528...57,477,534
Ensembl chr11:57,460,528...57,477,534
JBrowse link
G S100A8 S100 calcium binding protein A8 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of S100A8 mRNA CTD PMID:22563483 NCBI chr 1:153,390,032...153,422,583
Ensembl chr 1:153,390,032...153,391,073
JBrowse link
G S100A9 S100 calcium binding protein A9 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of S100A9 mRNA CTD PMID:22563483 NCBI chr 1:153,357,854...153,361,023
Ensembl chr 1:153,357,854...153,361,023
JBrowse link
G S100P S100 calcium binding protein P increases expression EXP Maneb results in increased expression of S100P mRNA; Maneb results in increased expression of S100P protein CTD PMID:32194361 NCBI chr 4:6,693,878...6,697,170
Ensembl chr 4:6,693,878...6,697,170
JBrowse link
G SAA2 serum amyloid A2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of SAA2 mRNA CTD PMID:22563483 NCBI chr11:18,238,236...18,248,668
Ensembl chr11:18,239,223...18,248,668
JBrowse link
G SCAMP2 secretory carrier membrane protein 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of SCAMP2 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SCAMP2 mRNA] CTD PMID:23963992 NCBI chr15:74,843,730...74,873,365
Ensembl chr15:74,843,730...74,873,365
JBrowse link
G SCAND1 SCAN domain containing 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of SCAND1 mRNA CTD PMID:22563483 NCBI chr20:35,953,624...35,959,472
Ensembl chr20:35,953,617...35,959,472
JBrowse link
G SDHB succinate dehydrogenase complex iron sulfur subunit B multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of SDHB mRNA CTD PMID:18386188 NCBI chr 1:17,018,722...17,054,032
Ensembl chr 1:17,018,722...17,054,032
JBrowse link
G SEMA4D semaphorin 4D multiple interactions ISO [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of SEMA4D mRNA CTD PMID:23017109 NCBI chr 9:89,360,787...89,498,113
Ensembl chr 9:89,360,787...89,498,130
JBrowse link
G SIRT1 sirtuin 1 decreases activity EXP Maneb results in decreased activity of SIRT1 protein CTD PMID:21251949 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390
JBrowse link
G SIRT2 sirtuin 2 decreases activity EXP Maneb results in decreased activity of SIRT2 protein CTD PMID:21251949 NCBI chr19:38,878,555...38,899,733
Ensembl chr19:38,878,555...38,899,862
JBrowse link
G SIRT3 sirtuin 3 decreases activity EXP Maneb results in decreased activity of SIRT3 protein CTD PMID:21251949 NCBI chr11:215,030...236,931
Ensembl chr11:215,030...236,931
JBrowse link
G SLC17A8 solute carrier family 17 member 8 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of SLC17A8 mRNA CTD PMID:22563483 NCBI chr12:100,357,074...100,422,055
Ensembl chr12:100,357,074...100,422,055
JBrowse link
G SLC18A2 solute carrier family 18 member A2 multiple interactions
decreases expression
ISO [Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA; Ketoconazole inhibits the reaction [Maneb results in decreased expression of SLC18A2 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA] CTD PMID:18386188 PMID:20964710 PMID:22334051 NCBI chr10:117,241,114...117,279,430
Ensembl chr10:117,241,093...117,279,430
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of SLC22A2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SLC22A2 mRNA] CTD PMID:23963992 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SLC40A1 solute carrier family 40 member 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of SLC40A1 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC40A1 protein] CTD PMID:30797899 NCBI chr 2:189,560,590...189,580,811
Ensembl chr 2:189,560,590...189,583,758
JBrowse link
G SLC5A7 solute carrier family 5 member 7 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of SLC5A7 mRNA CTD PMID:22563483 NCBI chr 2:107,986,524...108,014,497
Ensembl chr 2:107,986,523...108,013,994
JBrowse link
G SLC6A2 solute carrier family 6 member 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of SLC6A2 mRNA CTD PMID:22563483 NCBI chr16:55,655,928...55,706,192
Ensembl chr16:55,655,988...55,707,645
JBrowse link
G SLC6A3 solute carrier family 6 member 3 multiple interactions
affects response to substance
ISO
EXP
[Paraquat co-treated with Maneb] results in decreased expression of SLC6A3 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of SLC6A3 protein
SLC6A3 gene polymorphism affects the susceptibility to Maneb
CTD PMID:11124998 PMID:18386188 PMID:19590691 NCBI chr 5:1,392,794...1,445,440
Ensembl chr 5:1,392,794...1,445,440
JBrowse link
G SLC8A1 solute carrier family 8 member A1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of SLC8A1 mRNA CTD PMID:22563483 NCBI chr 2:40,097,270...40,512,435
Ensembl chr 2:40,097,270...40,611,053
JBrowse link
G SNCA synuclein alpha multiple interactions
increases response to substance
ISO
EXP
[Paraquat co-treated with Maneb] promotes the reaction [SNCA protein binds to SNCA protein]; [Paraquat co-treated with Maneb] results in increased expression of SNCA protein; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ADORA1 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of APBB1 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ASCL1 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP2 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DLL1 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD2 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD5 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEYL mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX5 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of SEMA4D mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] promotes the reaction [SNCA protein binds to SNCA protein]]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of SNCA protein]; SNCA protein inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] promotes the reaction [SNCA protein binds to SNCA protein]]
SNCA gene mutant form results in increased susceptibility to Maneb
[Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased abundance of Nitric Oxide; [Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased metabolism of MEF2C protein; [Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased abundance of Nitric Oxide; [Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased metabolism of MEF2C protein; Maneb promotes the reaction [Paraquat results in increased expression of SNCA protein]; Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]; Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]; SNCA protein mutant form results in increased susceptibility to [Paraquat co-treated with Maneb]; SNCA protein results in increased susceptibility to [Maneb co-treated with Paraquat]
CTD PMID:23017109 PMID:24290359 PMID:26498265 PMID:27324791 PMID:29568078 More... NCBI chr 4:89,724,099...89,838,324
Ensembl chr 4:89,700,345...89,838,315
JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP
ISO
SOD1 protein results in decreased susceptibility to [Paraquat co-treated with Maneb]
[Maneb co-treated with Paraquat] results in increased expression of SOD1 mRNA
[Paraquat co-treated with Maneb] results in decreased expression of SOD1 mRNA
CTD PMID:15824117 PMID:18386188 PMID:29859004 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
decreases expression
ISO [Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein]
Maneb results in decreased expression of SOD2 mRNA
CTD PMID:23562983 PMID:26210702 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of STAT3 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT3 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT3 mRNA] CTD PMID:23963992 NCBI chr17:42,313,324...42,388,502
Ensembl chr17:42,313,324...42,388,540
JBrowse link
G STAT4 signal transducer and activator of transcription 4 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA] CTD PMID:23963992 NCBI chr 2:191,029,576...191,172,684
Ensembl chr 2:191,029,576...191,151,596
JBrowse link
G STMN1 stathmin 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein] CTD PMID:23562983 NCBI chr 1:25,884,179...25,906,880
Ensembl chr 1:25,884,181...25,906,991
JBrowse link
G STON2 stonin 2 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of STON2 mRNA CTD PMID:22563483 NCBI chr14:81,260,652...81,436,465
Ensembl chr14:81,260,652...81,436,465
JBrowse link
G STRBP spermatid perinuclear RNA binding protein multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of STRBP mRNA CTD PMID:22563483 NCBI chr 9:123,109,494...123,268,586
Ensembl chr 9:123,109,500...123,268,586
JBrowse link
G SUMO1 small ubiquitin like modifier 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of SUMO1 mRNA CTD PMID:18386188 NCBI chr 2:202,206,171...202,238,597
Ensembl chr 2:202,206,182...202,238,599
JBrowse link
G SYT5 synaptotagmin 5 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of SYT5 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SYT5 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SYT5 mRNA] CTD PMID:23963992 NCBI chr19:55,171,196...55,180,441
Ensembl chr19:55,171,196...55,180,289
JBrowse link
G TBCK TBC1 domain containing kinase multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of TBCK mRNA CTD PMID:22563483 NCBI chr 4:106,041,599...106,316,683
Ensembl chr 4:106,041,599...106,316,683
JBrowse link
G TECR trans-2,3-enoyl-CoA reductase multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of TECR mRNA CTD PMID:18386188 NCBI chr19:14,527,752...14,565,980
Ensembl chr19:14,517,085...14,565,980
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of TGFB1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TGFB1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TGFB1 mRNA] CTD PMID:23963992 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922
JBrowse link
G TH tyrosine hydroxylase multiple interactions
decreases expression
ISO 4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]; [Paraquat co-treated with Maneb] results in decreased expression of TH protein; [Paraquat co-treated with Maneb] results in increased expression of TH protein; Genistein inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]; Ketoconazole inhibits the reaction [Maneb results in decreased expression of TH protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]; pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]; prolinedithiocarbamate inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]
[Paraquat co-treated with Maneb] results in decreased expression of TH; [Paraquat co-treated with Maneb] results in decreased expression of TH mRNA; [Paraquat co-treated with Maneb] results in decreased expression of TH protein
CTD PMID:11124998 PMID:18386188 PMID:20455021 PMID:20964710 PMID:22334051 More... NCBI chr11:2,163,929...2,174,081
Ensembl chr11:2,163,929...2,171,815
JBrowse link
G TIMM13 translocase of inner mitochondrial membrane 13 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of TIMM13 mRNA CTD PMID:18386188 NCBI chr19:2,425,625...2,427,586
Ensembl chr19:2,425,625...2,427,586
JBrowse link
G TMEM42 transmembrane protein 42 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of TMEM42 mRNA CTD PMID:22563483 NCBI chr 3:44,861,912...44,865,664
Ensembl chr 3:44,861,904...44,865,670
JBrowse link
G TNF tumor necrosis factor increases expression
multiple interactions
ISO Maneb results in increased expression of TNF mRNA
[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA; [Paraquat co-treated with Maneb] results in increased expression of TNF mRNA; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]
[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Maneb results in increased expression of TNF mRNA]
CTD PMID:23159886 PMID:23963992 PMID:28202386 PMID:29568078 PMID:30797899 More... NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336
JBrowse link
G TNFAIP3 TNF alpha induced protein 3 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA] CTD PMID:23963992 NCBI chr 6:137,866,317...137,883,312
Ensembl chr 6:137,867,214...137,883,312
JBrowse link
G TNR tenascin R multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of TNR mRNA CTD PMID:23017109 NCBI chr 1:175,315,194...175,743,702
Ensembl chr 1:175,315,194...175,743,616
JBrowse link
G TP53 tumor protein p53 multiple interactions ISO 3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TRP53 protein]; [Maneb co-treated with Paraquat] results in increased expression of TRP53 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of TRP53 protein; [Paraquat co-treated with Maneb] results in increased activity of TRP53 protein modified form; [Paraquat co-treated with Maneb] results in increased expression of TRP53 protein; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRP53 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TRP53 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of TRP53 protein modified form]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRP53 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TRP53 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of TRP53 protein modified form] CTD PMID:20964710 PMID:23963992 PMID:23985028 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,538
JBrowse link
G TRAF3IP2 TRAF3 interacting protein 2 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of ACT1 protein CTD PMID:23562983 NCBI chr 6:111,555,381...111,605,878
Ensembl chr 6:111,555,381...111,606,906
JBrowse link
G TRAF6 TNF receptor associated factor 6 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA] CTD PMID:23963992 NCBI chr11:36,483,769...36,510,313
Ensembl chr11:36,483,769...36,510,272
JBrowse link
G TRPM3 transient receptor potential cation channel subfamily M member 3 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of TRPM3 mRNA CTD PMID:22563483 NCBI chr 9:70,529,060...71,446,971
Ensembl chr 9:70,529,060...71,446,904
JBrowse link
G TUBA1A tubulin alpha 1a multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein] CTD PMID:23562983 NCBI chr12:49,184,795...49,189,080
Ensembl chr12:49,184,686...49,189,080
JBrowse link
G TUBA1B tubulin alpha 1b multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of TUBA1B mRNA CTD PMID:18386188 NCBI chr12:49,127,782...49,131,395
Ensembl chr12:49,127,782...49,131,397
JBrowse link
G TUBB tubulin beta class I multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of TUBB5 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of TUBB5 mRNA] CTD PMID:23963992 NCBI chr 6:30,720,352...30,725,422
Ensembl chr 6:30,717,435...30,725,538
JBrowse link
G TUSC1 tumor suppressor candidate 1 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of TUSC1 mRNA CTD PMID:22563483 NCBI chr 9:25,676,969...25,678,444
Ensembl chr 9:25,676,969...25,678,444
JBrowse link
G TXN thioredoxin increases expression EXP [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of TXN1 mRNA CTD PMID:21402726 NCBI chr 9:110,243,810...110,256,507
Ensembl chr 9:110,243,810...110,256,507
JBrowse link
G TXNRD1 thioredoxin reductase 1 increases expression EXP [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA CTD PMID:21402726 NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307
JBrowse link
G UBA1 ubiquitin like modifier activating enzyme 1 multiple interactions EXP Maneb results in decreased activity of and results in decreased ubiquitination of UBA1 protein CTD PMID:25714994 NCBI chr  X:47,190,847...47,215,128
Ensembl chr  X:47,190,861...47,215,128
JBrowse link
G UBB ubiquitin B multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of UBB mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of UBB mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of UBB mRNA] CTD PMID:23963992 NCBI chr17:16,380,779...16,382,745
Ensembl chr17:16,380,798...16,382,745
JBrowse link
G UBC ubiquitin C multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of UBC mRNA CTD PMID:18386188 NCBI chr12:124,911,646...124,914,650
Ensembl chr12:124,911,604...124,917,368
JBrowse link
G UBXN7 UBX domain protein 7 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of UBXN7 mRNA CTD PMID:22563483 NCBI chr 3:196,347,659...196,454,323
Ensembl chr 3:196,347,662...196,432,430
JBrowse link
G UCHL1 ubiquitin C-terminal hydrolase L1 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of UCHL1 protein; [Paraquat co-treated with Maneb] results in decreased expression of UCHL1 mRNA CTD PMID:18386188 PMID:23562983 NCBI chr 4:41,256,928...41,268,455
Ensembl chr 4:41,256,413...41,268,455
JBrowse link
G UCHL5 ubiquitin C-terminal hydrolase L5 multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of UCHL5 mRNA CTD PMID:18386188 NCBI chr 1:193,012,254...193,060,140
Ensembl chr 1:193,012,250...193,060,080
JBrowse link
G UNC13C unc-13 homolog C multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of UNC13C mRNA CTD PMID:22563483 NCBI chr15:53,837,573...54,633,440
Ensembl chr15:53,978,201...54,628,707
JBrowse link
G UPF3B UPF3B regulator of nonsense mediated mRNA decay multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of UPF3B mRNA CTD PMID:18386188 NCBI chr  X:119,805,311...119,853,028
Ensembl chr  X:119,805,311...119,852,998
JBrowse link
G UQCRC1 ubiquinol-cytochrome c reductase core protein 1 multiple interactions ISO [Maneb co-treated with Paraquat] results in increased expression of UQCRC1 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of UQCRC1 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of UQCRC1 protein] CTD PMID:23562983 NCBI chr 3:48,599,002...48,609,664
Ensembl chr 3:48,599,002...48,610,976
JBrowse link
G VAMP5 vesicle associated membrane protein 5 multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of VAMP5 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VAMP5 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VAMP5 mRNA] CTD PMID:23963992 NCBI chr 2:85,584,431...85,593,406
Ensembl chr 2:85,584,431...85,593,406
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions ISO [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA CTD PMID:23017109 NCBI chr 6:43,770,209...43,786,487
Ensembl chr 6:43,770,184...43,786,487
JBrowse link
G VPS45 vacuolar protein sorting 45 homolog multiple interactions ISO [Maneb co-treated with Paraquat] results in decreased expression of VPS45 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VPS45 mRNA] CTD PMID:23963992 NCBI chr 1:150,067,279...150,145,329
Ensembl chr 1:150,067,279...150,145,329
JBrowse link
G WNT1 Wnt family member 1 multiple interactions ISO [Paraquat co-treated with Maneb] results in decreased expression of WNT1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of WNT1 protein CTD PMID:29152652 NCBI chr12:48,978,322...48,982,620
Ensembl chr12:48,978,322...48,982,620
JBrowse link
G WNT5A Wnt family member 5A multiple interactions ISO [Paraquat co-treated with Maneb] results in increased expression of WNT5A mRNA; [Paraquat co-treated with Maneb] results in increased expression of WNT5A protein CTD PMID:29152652 NCBI chr 3:55,465,715...55,505,261
Ensembl chr 3:55,465,715...55,490,539
JBrowse link
G ZBTB44 zinc finger and BTB domain containing 44 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ZBTB44 mRNA CTD PMID:22563483 NCBI chr11:130,226,677...130,314,917
Ensembl chr11:130,226,677...130,314,917
JBrowse link
G ZHX3 zinc fingers and homeoboxes 3 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ZHX3 mRNA CTD PMID:22563483 NCBI chr20:41,178,450...41,317,731
Ensembl chr20:41,178,448...41,317,731
JBrowse link
G ZNF580 zinc finger protein 580 multiple interactions ISO [Paraquat co-treated with Maneb] affects the expression of ZFP580 mRNA CTD PMID:22563483 NCBI chr19:55,641,002...55,643,470
Ensembl chr19:55,635,016...55,643,470
JBrowse link
manganese dioxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase (Cartwright blood group) decreases expression ISO manganese dioxide results in decreased expression of ACHE protein CTD PMID:23702825 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G GPT glutamic--pyruvic transaminase increases activity ISO manganese dioxide results in increased activity of GPT protein CTD PMID:23702825 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174
JBrowse link
manganese(0) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA5 ATP binding cassette subfamily A member 5 decreases expression EXP Manganese results in decreased expression of ABCA5 mRNA CTD PMID:17175027 NCBI chr17:69,244,311...69,327,133
Ensembl chr17:69,244,311...69,327,244
JBrowse link
G ABCA9 ATP binding cassette subfamily A member 9 increases expression EXP Manganese results in increased expression of ABCA9 mRNA CTD PMID:17175027 NCBI chr17:68,974,488...69,078,978
Ensembl chr17:68,974,488...69,060,949
JBrowse link
G ABCB1 ATP binding cassette subfamily B member 1 increases activity
increases expression
multiple interactions
EXP
ISO
Manganese results in increased activity of ABCB1 protein
Manganese results in increased expression of ABCB1A mRNA
[Manganese results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate
CTD PMID:2900677 PMID:26745496 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323
JBrowse link
G ABCC6 ATP binding cassette subfamily C member 6 multiple interactions ISO Manganese promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]; Manganese promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]] CTD PMID:12069597 NCBI chr16:16,149,565...16,223,617
Ensembl chr16:16,149,565...16,223,522
JBrowse link
G ABCC8 ATP binding cassette subfamily C member 8 multiple interactions EXP [manganese chloride results in increased abundance of Manganese] which results in increased expression of ABCC8 protein CTD PMID:32659473 NCBI chr11:17,392,498...17,476,849
Ensembl chr11:17,392,498...17,476,894
JBrowse link
G ABI2 abl interactor 2 increases expression EXP Manganese results in increased expression of ABI2 mRNA CTD PMID:17175027 NCBI chr 2:203,325,013...203,432,169
Ensembl chr 2:203,328,280...203,447,728
JBrowse link
G ACAT2 acetyl-CoA acetyltransferase 2 decreases expression ISO Manganese results in decreased expression of ACAT2 mRNA CTD PMID:23499988 NCBI chr 6:159,762,045...159,779,112
Ensembl chr 6:159,762,045...159,779,112
JBrowse link
G ACHE acetylcholinesterase (Cartwright blood group) multiple interactions
increases activity
ISO [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased activity of ACHE protein]; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein]; Taurine inhibits the reaction [Manganese results in increased activity of ACHE protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of ACHE mRNA alternative form
CTD PMID:24885898 PMID:30738988 PMID:30844427 PMID:32445656 PMID:33314588 NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974
JBrowse link
G ACO1 aconitase 1 decreases activity
increases activity
multiple interactions
ISO
EXP
Manganese results in decreased activity of ACO1 protein
Manganese results in increased activity of ACO1 protein
Manganese results in increased stability of [ACO1 protein binds to SLC11A2 mRNA]
CTD PMID:16386771 PMID:16545456 PMID:16568477 PMID:16729984 PMID:17469137 NCBI chr 9:32,384,643...32,454,769
Ensembl chr 9:32,384,603...32,454,769
JBrowse link
G ACO2 aconitase 2 multiple interactions
decreases activity
decreases expression
EXP
ISO
ferric ammonium citrate inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
Iron inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
Manganese results in decreased expression of ACO2 mRNA; Manganese results in decreased expression of ACO2 protein
CTD PMID:9675333 PMID:16625280 PMID:17469137 NCBI chr22:41,468,756...41,528,979
Ensembl chr22:41,447,830...41,529,273
JBrowse link
G ACTA1 actin alpha 1, skeletal muscle decreases expression ISO Manganese results in decreased expression of ACTA1 mRNA CTD PMID:26745496 NCBI chr 1:229,431,245...229,434,094
Ensembl chr 1:229,430,365...229,434,104
JBrowse link
G ACTR3 actin related protein 3 affects expression ISO Manganese affects the expression of ACTR3 protein CTD PMID:24885898 NCBI chr 2:113,889,934...113,962,596
Ensembl chr 2:113,890,063...113,962,596
JBrowse link
G ADGRE1 adhesion G protein-coupled receptor E1 increases expression ISO Manganese results in increased expression of ADGRE1 mRNA CTD PMID:20224926 NCBI chr19:6,887,549...6,940,450
Ensembl chr19:6,887,566...6,940,459
JBrowse link
G ADM adrenomedullin increases expression EXP Manganese results in increased expression of ADM mRNA CTD PMID:17175027 NCBI chr11:10,305,073...10,307,397
Ensembl chr11:10,305,073...10,307,397
JBrowse link
G AFP alpha fetoprotein decreases expression ISO Manganese results in decreased expression of AFP mRNA CTD PMID:26745496 NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174
JBrowse link
G AKAP7 A-kinase anchoring protein 7 decreases expression EXP Manganese results in decreased expression of AKAP7 mRNA CTD PMID:17175027 NCBI chr 6:131,125,698...131,283,534
Ensembl chr 6:131,135,467...131,283,535
JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases expression
multiple interactions
increases phosphorylation
EXP
ISO
Manganese results in decreased expression of AKT1 protein
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein]
NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein]
Manganese results in increased phosphorylation of AKT1 protein
CTD PMID:17043766 PMID:24845367 PMID:31676349 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751
JBrowse link
G ANGPT2 angiopoietin 2 decreases expression ISO Manganese results in decreased expression of ANGPT2 mRNA CTD PMID:26745496 NCBI chr 8:6,499,632...6,563,245
Ensembl chr 8:6,499,632...6,563,409
JBrowse link
G ANGPTL4 angiopoietin like 4 increases expression EXP Manganese results in increased expression of ANGPTL4 mRNA CTD PMID:17175027 NCBI chr19:8,364,129...8,374,373
Ensembl chr19:8,363,289...8,374,370
JBrowse link
G AP3B2 adaptor related protein complex 3 subunit beta 2 increases expression EXP Manganese results in increased expression of AP3B2 mRNA CTD PMID:17175027 NCBI chr15:82,659,281...82,709,875
Ensembl chr15:82,659,281...82,710,112
JBrowse link
G APOL1 apolipoprotein L1 increases expression EXP Manganese results in increased expression of APOL1 mRNA CTD PMID:17175027 NCBI chr22:36,253,071...36,267,531
Ensembl chr22:36,253,071...36,267,530
JBrowse link
G APOL2 apolipoprotein L2 increases expression EXP Manganese results in increased expression of APOL2 mRNA CTD PMID:17175027 NCBI chr22:36,226,209...36,239,954
Ensembl chr22:36,226,209...36,239,954
JBrowse link
G APP amyloid beta precursor protein increases expression EXP Manganese results in increased expression of APP mRNA CTD PMID:18583042 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,550...26,171,128
JBrowse link
G AQP4 aquaporin 4 multiple interactions ISO Antioxidants inhibits the reaction [Manganese results in increased expression of AQP4 protein] CTD PMID:20648640 NCBI chr18:26,852,038...26,865,803
Ensembl chr18:26,852,043...26,865,771
JBrowse link
G ARG1 arginase 1 affects binding
multiple interactions
EXP
ISO
Manganese binds to ARG1 protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of ARG1 mRNA
CTD PMID:15248756 PMID:18802628 PMID:34018660 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332
JBrowse link
G ARHGDIA Rho GDP dissociation inhibitor alpha decreases expression EXP Manganese results in decreased expression of ARHGDIA mRNA CTD PMID:17175027 NCBI chr17:81,867,719...81,871,337
Ensembl chr17:81,867,721...81,871,378
JBrowse link
G ARHGEF4 Rho guanine nucleotide exchange factor 4 increases expression EXP Manganese results in increased expression of ARHGEF4 mRNA CTD PMID:17175027 NCBI chr 2:130,836,914...131,047,253
Ensembl chr 2:130,836,914...131,047,263
JBrowse link
G ATF1 activating transcription factor 1 increases phosphorylation
multiple interactions
ISO Manganese results in increased phosphorylation of ATF1 protein
SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of ATF1 protein]
CTD PMID:16787641 NCBI chr12:50,763,682...50,821,162
Ensembl chr12:50,763,710...50,821,162
JBrowse link
G ATF6 activating transcription factor 6 decreases expression EXP Manganese results in decreased expression of ATF6 mRNA CTD PMID:17175027 NCBI chr 1:161,766,320...161,964,070
Ensembl chr 1:161,766,298...161,977,574
JBrowse link
G ATM ATM serine/threonine kinase decreases expression EXP Manganese results in decreased expression of ATM mRNA CTD PMID:17175027 NCBI chr11:108,222,484...108,369,102
Ensembl chr11:108,223,044...108,369,102
JBrowse link
G ATOH8 atonal bHLH transcription factor 8 decreases expression ISO Manganese results in decreased expression of ATOH8 mRNA CTD PMID:26745496 NCBI chr 2:85,753,786...85,791,383
Ensembl chr 2:85,751,344...85,791,383
JBrowse link
G ATP13A2 ATPase cation transporting 13A2 affects response to substance
decreases response to substance
EXP ATP13A2 gene polymorphism affects the susceptibility to Manganese
ATP13A2 protein results in decreased susceptibility to Manganese
CTD PMID:22285144 PMID:22847264 NCBI chr 1:16,985,958...17,011,972
Ensembl chr 1:16,985,958...17,011,928
JBrowse link
G ATP1A3 ATPase Na+/K+ transporting subunit alpha 3 decreases expression
increases methylation
ISO Manganese results in decreased expression of ATP1A3 mRNA
Manganese results in increased methylation of ATP1A3 promoter
CTD PMID:23976782 NCBI chr19:41,966,582...41,994,230
Ensembl chr19:41,966,582...41,997,497
JBrowse link
G ATP7A ATPase copper transporting alpha affects localization
decreases expression
ISO Manganese affects the localization of ATP7A protein
Manganese results in decreased expression of ATP7A mRNA; Manganese results in decreased expression of ATP7A protein
CTD PMID:24614235 NCBI chr  X:77,910,693...78,050,395
Ensembl chr  X:77,910,690...78,050,395
JBrowse link
G ATP7B ATPase copper transporting beta increases phosphorylation
decreases expression
affects localization
EXP
ISO
Manganese results in increased phosphorylation of ATP7B protein
Manganese results in decreased expression of ATP7B mRNA; Manganese results in decreased expression of ATP7B protein
Manganese affects the localization of ATP7B protein
CTD PMID:19405516 PMID:24614235 NCBI chr13:51,932,669...52,012,130
Ensembl chr13:51,930,436...52,012,125
JBrowse link
G ATP8A1 ATPase phospholipid transporting 8A1 decreases expression EXP Manganese results in decreased expression of ATP8A1 mRNA CTD PMID:17175027 NCBI chr 4:42,408,373...42,657,105
Ensembl chr 4:42,408,373...42,657,105
JBrowse link
G BACE1 beta-secretase 1 increases expression EXP Manganese results in increased expression of BACE1 mRNA CTD PMID:18583042 NCBI chr11:117,285,698...117,316,256
Ensembl chr11:117,285,232...117,316,259
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO
EXP
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of BAX protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; [Manganese co-treated with NGF protein] results in increased expression of BAX protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased expression of BAX protein]; Rolipram inhibits the reaction [Manganese results in increased expression of BAX protein]
NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]
[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]
CTD PMID:25027559 PMID:25791630 PMID:30844427 PMID:30951808 PMID:31161640 More... NCBI chr19:48,954,825...48,961,798
Ensembl chr19:48,954,815...48,961,798
JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions
decreases expression
ISO [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased expression of BCL2 protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein]; Rolipram inhibits the reaction [Manganese results in decreased expression of BCL2 protein] CTD PMID:30844427 PMID:30951808 PMID:31161640 PMID:31676349 PMID:33314588 NCBI chr18:63,123,346...63,320,280
Ensembl chr18:63,123,346...63,320,128
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression
multiple interactions
ISO Manganese results in decreased expression of BCL2L1 protein
[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein]
CTD PMID:25791630 NCBI chr20:31,664,452...31,723,963
Ensembl chr20:31,664,452...31,723,989
JBrowse link
G BDNF brain derived neurotrophic factor multiple interactions
decreases expression
ISO
EXP
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BDNF protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]; Rolipram inhibits the reaction [Manganese results in decreased expression of BDNF protein]
Manganese results in decreased expression of BDNF mRNA; Manganese results in decreased expression of BDNF protein
CTD PMID:17827730 PMID:25099302 PMID:29205667 PMID:30951808 PMID:31161640 More... NCBI chr11:27,654,893...27,722,030
Ensembl chr11:27,654,893...27,722,058
JBrowse link
G BNIP3 BCL2 interacting protein 3 multiple interactions ISO Antioxidants inhibits the reaction [Manganese results in increased expression of BNIP3 protein] CTD PMID:19442826 NCBI chr10:131,967,684...131,981,923
Ensembl chr10:131,967,684...131,981,967
JBrowse link
G BUB1 BUB1 mitotic checkpoint serine/threonine kinase decreases expression EXP Manganese results in decreased expression of BUB1 mRNA CTD PMID:17175027 NCBI chr 2:110,637,528...110,678,063
Ensembl chr 2:110,637,528...110,678,063
JBrowse link
G CA8 carbonic anhydrase 8 increases expression ISO Manganese results in increased expression of CAR8 mRNA CTD PMID:26745496 NCBI chr 8:60,185,412...60,281,400
Ensembl chr 8:60,185,412...60,281,400
JBrowse link
G CALCOCO2 calcium binding and coiled-coil domain 2 increases expression EXP Manganese results in increased expression of CALCOCO2 mRNA CTD PMID:17175027 NCBI chr17:48,831,035...48,865,245
Ensembl chr17:48,831,018...48,866,522
JBrowse link
G CALR calreticulin affects expression ISO Manganese affects the expression of CALR protein CTD PMID:24885898 NCBI chr19:12,938,609...12,944,489
Ensembl chr19:12,938,578...12,944,489
JBrowse link
G CAMK2A calcium/calmodulin dependent protein kinase II alpha decreases phosphorylation ISO Manganese results in decreased phosphorylation of CAMK2A protein CTD PMID:26616912 NCBI chr 5:150,219,491...150,290,130
Ensembl chr 5:150,219,491...150,290,093
JBrowse link
G CAPN1 calpain 1 increases activity
multiple interactions
ISO Manganese results in increased activity of CAPN1 protein
calpain inhibitor III inhibits the reaction [Manganese results in increased activity of CAPN1 protein]
CTD PMID:21985864 NCBI chr11:65,181,373...65,212,006
Ensembl chr11:65,180,566...65,212,006
JBrowse link
G CASP3 caspase 3 multiple interactions
increases activity
increases expression
increases cleavage
ISO
EXP
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of CASP3 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein; aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Manganese results in increased activity of CASP3 protein]; Deferoxamine inhibits the reaction [Manganese results in increased activity of CASP3 protein]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein]; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; Manganese promotes the reaction [SP1 protein modified form binds to CASP3 promoter]; Manganese results in increased expression of and results in increased cleavage of CASP3 protein; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of CASP3 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [Manganese results in increased activity of CASP3 protein]; rhodioloside inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [Manganese results in increased expression of CASP3 mRNA]; U 0126 inhibits the reaction [Manganese results in increased expression of CASP3 protein]
SNCA protein inhibits the reaction [Manganese results in increased activity of CASP3 protein]
Manganese results in increased expression of CASP3 mRNA; Manganese results in increased expression of CASP3 protein
CTD PMID:11933051 PMID:16787641 PMID:21985864 PMID:22427945 PMID:22841634 More... NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,649,509
JBrowse link
G CASP7 caspase 7 increases activity ISO Manganese results in increased activity of CASP7 protein CTD PMID:22427945 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907
JBrowse link
G CASP8 caspase 8 increases activity
multiple interactions
ISO Manganese results in increased activity of CASP8 protein
Rolipram inhibits the reaction [Manganese results in increased activity of CASP8 protein]
CTD PMID:31161640 NCBI chr 2:201,233,443...201,287,711
Ensembl chr 2:201,233,443...201,287,711
JBrowse link
G CASP9 caspase 9 increases cleavage
increases activity
multiple interactions
ISO
EXP
Manganese results in increased cleavage of CASP9 protein
Manganese results in increased activity of CASP9 protein
SNCA protein inhibits the reaction [Manganese results in increased activity of CASP9 protein]
CTD PMID:16787641 PMID:25416158 NCBI chr 1:15,491,401...15,524,912
Ensembl chr 1:15,490,832...15,526,534
JBrowse link
G CAT catalase multiple interactions
decreases activity
ISO [manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; CAT protein inhibits the reaction [[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]]
Manganese results in decreased activity of CAT protein
[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of CAT protein; [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased activity of CAT protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; CAT protein inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; CAT protein inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Manganese results in decreased activity of CAT protein]
CTD PMID:16595185 PMID:17176674 PMID:23339144 PMID:25817889 PMID:30844427 More... NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060
JBrowse link
G CAV1 caveolin 1 decreases expression ISO Manganese results in decreased expression of CAV1 mRNA; Manganese results in decreased expression of CAV1 protein CTD PMID:23499988 PMID:23597857 NCBI chr 7:116,525,009...116,561,185
Ensembl chr 7:116,524,994...116,561,179
JBrowse link
G CAV3 caveolin 3 decreases expression ISO Manganese results in decreased expression of CAV3 mRNA; Manganese results in decreased expression of CAV3 protein CTD PMID:23597857 NCBI chr 3:8,733,802...8,746,758
Ensembl chr 3:8,733,802...8,841,808
JBrowse link
G CCL2 C-C motif chemokine ligand 2 increases expression ISO Manganese results in increased expression of CCL2 mRNA CTD PMID:19782702 NCBI chr17:34,255,285...34,257,203
Ensembl chr17:34,255,218...34,257,203
JBrowse link
G CCL7 C-C motif chemokine ligand 7 increases expression EXP Manganese results in increased expression of CCL7 mRNA CTD PMID:17175027 NCBI chr17:34,270,221...34,272,242
Ensembl chr17:34,270,221...34,272,242
JBrowse link
G CCNA1 cyclin A1 increases expression ISO Manganese results in increased expression of CCNA1 mRNA CTD PMID:26745496 NCBI chr13:36,430,488...36,442,870
Ensembl chr13:36,431,520...36,442,870
JBrowse link
G CCNB2 cyclin B2 decreases expression EXP Manganese results in decreased expression of CCNB2 mRNA CTD PMID:17175027 NCBI chr15:59,105,146...59,125,045
Ensembl chr15:59,105,126...59,125,045
JBrowse link
G CCND1 cyclin D1 increases expression ISO Manganese results in increased expression of CCND1 mRNA CTD PMID:23997110 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CD48 CD48 molecule increases expression EXP Manganese results in increased expression of CD48 mRNA CTD PMID:17175027 NCBI chr 1:160,678,746...160,711,836
Ensembl chr 1:160,678,746...160,711,831
JBrowse link
G CD8B CD8b molecule increases expression EXP Manganese results in increased expression of CD8B mRNA; Manganese results in increased expression of CD8B1 mRNA CTD PMID:17175027 NCBI chr 2:86,815,369...86,861,886
Ensembl chr 2:86,815,339...86,861,924
JBrowse link
G CDKN2C cyclin dependent kinase inhibitor 2C decreases expression EXP Manganese results in decreased expression of CDKN2C mRNA CTD PMID:17175027 NCBI chr 1:50,968,706...50,974,634
Ensembl chr 1:50,960,745...50,974,634
JBrowse link
G CDKN3 cyclin dependent kinase inhibitor 3 decreases expression EXP Manganese results in decreased expression of CDKN3 mRNA CTD PMID:17175027 NCBI chr14:54,396,873...54,420,218
Ensembl chr14:54,396,849...54,420,218
JBrowse link
G CEBPD CCAAT enhancer binding protein delta increases expression EXP Manganese results in increased expression of CEBPD mRNA CTD PMID:17175027 NCBI chr 8:47,736,913...47,738,164
Ensembl chr 8:47,736,913...47,738,164
JBrowse link
G CELSR1 cadherin EGF LAG seven-pass G-type receptor 1 increases expression EXP Manganese results in increased expression of CELSR1 mRNA CTD PMID:17175027 NCBI chr22:46,361,174...46,537,620
Ensembl chr22:46,360,834...46,537,620
JBrowse link
G CEP128 centrosomal protein 128 decreases expression EXP Manganese results in decreased expression of CEP128 mRNA CTD PMID:17175027 NCBI chr14:80,478,321...80,959,501
Ensembl chr14:80,476,983...80,959,517
JBrowse link
G CHAT choline O-acetyltransferase decreases activity
multiple interactions
ISO Manganese results in decreased activity of CHAT protein
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CHAT protein
Taurine inhibits the reaction [Manganese results in decreased activity of CHAT protein]
CTD PMID:24885898 PMID:30738988 NCBI chr10:49,609,095...49,667,942
Ensembl chr10:49,609,095...49,667,942
JBrowse link
G CKS2 CDC28 protein kinase regulatory subunit 2 decreases expression EXP Manganese results in decreased expression of CKS2 mRNA CTD PMID:17175027 NCBI chr 9:89,311,195...89,316,703
Ensembl chr 9:89,311,195...89,316,703
JBrowse link
G CLDN23 claudin 23 increases expression ISO Manganese results in increased expression of CLDN23 mRNA CTD PMID:26745496 NCBI chr 8:8,701,937...8,704,096
Ensembl chr 8:8,701,937...8,704,096
JBrowse link
G CLN6 CLN6 transmembrane ER protein increases abundance ISO CLN6 gene mutant form results in increased abundance of Manganese CTD PMID:23789114 NCBI chr15:68,206,992...68,229,728
Ensembl chr15:68,206,992...68,257,211
JBrowse link
G CNOT2 CCR4-NOT transcription complex subunit 2 decreases expression EXP Manganese results in decreased expression of CNOT2 mRNA CTD PMID:17175027 NCBI chr12:70,242,993...70,354,993
Ensembl chr12:70,243,002...70,354,993
JBrowse link
G CNOT6L CCR4-NOT transcription complex subunit 6 like increases expression EXP Manganese results in increased expression of CNOT6L mRNA CTD PMID:17175027 NCBI chr 4:77,713,387...77,820,269
Ensembl chr 4:77,713,387...77,819,615
JBrowse link
G COL12A1 collagen type XII alpha 1 chain decreases expression EXP Manganese results in decreased expression of COL12A1 mRNA CTD PMID:17175027 NCBI chr 6:75,084,326...75,206,262
Ensembl chr 6:75,084,326...75,206,267
JBrowse link
G CPM carboxypeptidase M decreases expression EXP Manganese results in decreased expression of CPM mRNA CTD PMID:17175027 NCBI chr12:68,842,193...68,963,469
Ensembl chr12:68,842,197...68,971,570
JBrowse link
G CR1 complement C3b/C4b receptor 1 (Knops blood group) increases expression EXP Manganese results in increased expression of CR1 mRNA CTD PMID:17175027 NCBI chr 1:207,496,157...207,641,765
Ensembl chr 1:207,496,147...207,641,765
JBrowse link
G CREB1 cAMP responsive element binding protein 1 increases phosphorylation
decreases phosphorylation
multiple interactions
decreases expression
ISO
EXP
Manganese results in increased phosphorylation of CREB1 protein
Manganese results in decreased phosphorylation of CREB1 protein
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CREB1 protein; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein]
Manganese results in decreased expression of CREB1 mRNA; Manganese results in decreased expression of CREB1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; Rolipram inhibits the reaction [Manganese results in decreased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of CREB1 protein]
CTD PMID:16787641 PMID:29205667 PMID:30951808 PMID:31161640 PMID:31676349 More... NCBI chr 2:207,529,943...207,605,988
Ensembl chr 2:207,529,737...207,605,988
JBrowse link
G CRH corticotropin releasing hormone multiple interactions ISO CRH protein inhibits the reaction [Manganese results in increased chemical synthesis of Cyclic AMP] CTD PMID:2153673 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464
JBrowse link
G CRYM crystallin mu affects expression ISO Manganese affects the expression of CRYM protein CTD PMID:24885898 NCBI chr16:21,258,521...21,303,062
Ensembl chr16:21,238,874...21,303,083
JBrowse link
G CSRP3 cysteine and glycine rich protein 3 increases expression ISO Manganese results in increased expression of CSRP3 mRNA CTD PMID:26745496 NCBI chr11:19,182,030...19,201,983
Ensembl chr11:19,182,030...19,210,571
JBrowse link
G CTNNA1 catenin alpha 1 decreases expression EXP Manganese results in decreased expression of CTNNA1 mRNA CTD PMID:17175027 NCBI chr 5:138,753,425...138,935,034
Ensembl chr 5:138,610,967...138,935,034
JBrowse link
G CTNNB1 catenin beta 1 decreases expression EXP Manganese results in decreased expression of CTNNB1 mRNA CTD PMID:17175027 NCBI chr 3:41,199,422...41,240,445
Ensembl chr 3:41,194,741...41,260,096
JBrowse link
G CXCL12 C-X-C motif chemokine ligand 12 decreases expression ISO Manganese results in decreased expression of CXCL12 mRNA CTD PMID:23499988 NCBI chr10:44,292,088...44,385,097
Ensembl chr10:44,370,165...44,386,493
JBrowse link
G CXCL14 C-X-C motif chemokine ligand 14 increases expression EXP Manganese results in increased expression of CXCL14 mRNA CTD PMID:17175027 NCBI chr 5:135,570,679...135,578,991
Ensembl chr 5:135,570,679...135,579,279
JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 increases expression EXP
ISO
Manganese results in increased expression of CXCL2 mRNA CTD PMID:17175027 PMID:19782702 PMID:20224926 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196
JBrowse link
G CXCL3 C-X-C motif chemokine ligand 3 increases expression EXP Manganese results in increased expression of CXCL3 mRNA CTD PMID:17175027 NCBI chr 4:74,036,589...74,038,689
Ensembl chr 4:74,036,589...74,038,807
JBrowse link
G CXCL6 C-X-C motif chemokine ligand 6 increases expression EXP Manganese results in increased expression of CXCL6 mRNA CTD PMID:17175027 NCBI chr 4:73,836,678...73,838,760
Ensembl chr 4:73,836,640...73,849,064
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases secretion EXP Manganese results in increased secretion of CXCL8 protein CTD PMID:19263519 NCBI chr 4:73,740,569...73,743,716
Ensembl chr 4:73,740,541...73,743,716
JBrowse link
G CYCS cytochrome c, somatic multiple interactions
affects localization
EXP
ISO
SNCA protein inhibits the reaction [Manganese affects the localization of CYCS protein] CTD PMID:25416158 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260
JBrowse link
G CYP11A1 cytochrome P450 family 11 subfamily A member 1 decreases expression ISO Manganese results in decreased expression of CYP11A1 protein CTD PMID:25981801 NCBI chr15:74,337,762...74,367,646
Ensembl chr15:74,337,759...74,367,646
JBrowse link
G CYP26B1 cytochrome P450 family 26 subfamily B member 1 decreases expression ISO Manganese results in decreased expression of CYP26B1 mRNA CTD PMID:26745496 NCBI chr 2:72,129,238...72,147,862
Ensembl chr 2:72,129,238...72,147,862
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 decreases response to substance EXP CYP2D6 gene polymorphism results in decreased susceptibility to Manganese CTD PMID:12171760 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
increases activity
ISO [Manganese co-treated with Bilirubin] results in decreased activity of CYP7A1 protein
Manganese results in increased activity of CYP7A1 protein
CTD PMID:12700418 NCBI chr 8:58,490,178...58,500,163
Ensembl chr 8:58,490,178...58,500,163
JBrowse link
G DACH2 dachshund family transcription factor 2 increases expression EXP Manganese results in increased expression of DACH2 mRNA CTD PMID:17175027 NCBI chr  X:86,148,451...86,832,602
Ensembl chr  X:86,148,451...86,832,604
JBrowse link
G DAZ2 deleted in azoospermia 2 decreases expression EXP Manganese results in decreased expression of DAZ2 mRNA CTD PMID:17175027 NCBI chr  Y:23,219,457...23,291,356
Ensembl chr  Y:23,219,447...23,291,356
JBrowse link
G DCTN3 dynactin subunit 3 affects expression ISO Manganese affects the expression of DCTN3 protein CTD PMID:24885898 NCBI chr 9:34,613,546...34,620,518
Ensembl chr 9:34,613,545...34,620,523
JBrowse link
G DDAH1 dimethylarginine dimethylaminohydrolase 1 decreases expression
multiple interactions
ISO Manganese deficiency results in decreased expression of DDAH1 protein
Paroxetine inhibits the reaction [Manganese deficiency results in decreased expression of DDAH1 protein]
CTD PMID:21312047 NCBI chr 1:85,318,485...85,578,274
Ensembl chr 1:85,318,481...85,578,363
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression
multiple interactions
EXP
ISO
Manganese results in increased expression of DDIT3 protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of DDIT3 mRNA
Manganese results in increased expression of DDIT3 mRNA
CTD PMID:21477646 PMID:23499988 PMID:32574669 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737
JBrowse link
G DLD dihydrolipoamide dehydrogenase decreases expression ISO Manganese results in decreased expression of DLD protein CTD PMID:25981801 NCBI chr 7:107,891,107...107,921,198
Ensembl chr 7:107,891,162...107,931,730
JBrowse link
G DNAH14 dynein axonemal heavy chain 14 decreases expression EXP Manganese results in decreased expression of DNAH14 mRNA CTD PMID:17175027 NCBI chr 1:224,928,422...225,399,292
Ensembl chr 1:224,896,262...225,399,292
JBrowse link
G DNPH1 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 decreases expression EXP Manganese results in decreased expression of DNPH1 mRNA CTD PMID:17175027 NCBI chr 6:43,225,629...43,229,481
Ensembl chr 6:43,225,629...43,229,481
JBrowse link
G DPP4 dipeptidyl peptidase 4 increases expression EXP Manganese results in increased expression of DPP4 mRNA CTD PMID:17175027 NCBI chr 2:161,992,245...162,074,215
Ensembl chr 2:161,992,245...162,074,394
JBrowse link
G DR1 down-regulator of transcription 1 decreases expression EXP Manganese results in decreased expression of DR1 mRNA CTD PMID:17175027 NCBI chr 1:93,345,907...93,369,493
Ensembl chr 1:93,345,907...93,369,493
JBrowse link
G DRD2 dopamine receptor D2 decreases expression
affects expression
ISO
EXP
Manganese results in decreased expression of DRD2 mRNA
Manganese affects the expression of DRD2 protein
CTD PMID:20224926 PMID:33881537 NCBI chr11:113,409,605...113,475,398
Ensembl chr11:113,409,605...113,475,691
JBrowse link
G DSCAML1 DS cell adhesion molecule like 1 increases expression ISO Manganese results in increased expression of DSCAML1 mRNA CTD PMID:26745496 NCBI chr11:117,427,772...117,817,514
Ensembl chr11:117,427,772...117,817,525
JBrowse link
G DSPP dentin sialophosphoprotein increases expression EXP Manganese results in increased expression of DSPP mRNA CTD PMID:17175027 NCBI chr 4:87,608,529...87,616,873
Ensembl chr 4:87,608,529...87,616,873
JBrowse link
G DUSP1 dual specificity phosphatase 1 multiple interactions
decreases expression
ISO [Manganese co-treated with Lipopolysaccharides] results in decreased expression of DUSP1 mRNA; [Manganese co-treated with Lipopolysaccharides] results in decreased expression of DUSP1 protein
Manganese results in decreased expression of DUSP1 mRNA; Manganese results in decreased expression of DUSP1 protein
CTD PMID:20589745 NCBI chr 5:172,768,096...172,771,195
Ensembl chr 5:172,768,096...172,771,195
JBrowse link
G EIF2A eukaryotic translation initiation factor 2A increases expression EXP Manganese results in increased expression of EIF2A protein CTD PMID:21477646 NCBI chr 3:150,546,726...150,586,016
Ensembl chr 3:150,546,678...150,586,016
JBrowse link
G EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein] CTD PMID:32574669 NCBI chr 2:37,099,210...37,157,065
Ensembl chr 2:37,099,210...37,157,522
JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2AK3 protein CTD PMID:32574669 NCBI chr 2:88,556,741...88,627,464
Ensembl chr 2:88,556,741...88,691,518
JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha multiple interactions ISO [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2S1 protein CTD PMID:32574669 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516
JBrowse link
G ELF1 E74 like ETS transcription factor 1 decreases expression EXP Manganese results in decreased expression of ELF1 mRNA CTD PMID:17175027 NCBI chr13:40,931,919...41,061,386
Ensembl chr13:40,931,924...41,061,440
JBrowse link
G EML2 EMAP like 2 increases expression EXP Manganese results in increased expression of EML2 mRNA CTD PMID:17175027 NCBI chr19:45,609,400...45,645,629
Ensembl chr19:45,606,994...45,645,602
JBrowse link
G ENO1 enolase 1 decreases activity ISO Manganese results in decreased activity of ENO1 protein CTD PMID:22191580 NCBI chr 1:8,861,000...8,878,686
Ensembl chr 1:8,861,000...8,879,190
JBrowse link
G EPO erythropoietin increases glycosylation EXP Manganese results in increased glycosylation of EPO protein CTD PMID:16937399 NCBI chr 7:100,720,468...100,723,700
Ensembl chr 7:100,720,468...100,723,700
JBrowse link
G ERCC6L ERCC excision repair 6 like, spindle assembly checkpoint helicase decreases expression EXP Manganese results in decreased expression of ERCC6L mRNA CTD PMID:17175027 NCBI chr  X:72,204,665...72,239,027
Ensembl chr  X:72,204,657...72,239,027
JBrowse link
G EREG epiregulin increases expression EXP Manganese results in increased expression of EREG mRNA CTD PMID:17175027 NCBI chr 4:74,365,145...74,388,749
Ensembl chr 4:74,365,145...74,388,749
JBrowse link
G ERICH1 glutamate rich 1 increases expression EXP Manganese results in increased expression of ERICH1 mRNA CTD PMID:17175027 NCBI chr 8:614,742...731,224
Ensembl chr 8:614,746...738,106
JBrowse link
G ESR1 estrogen receptor 1 increases expression ISO Manganese results in increased expression of ESR1 protein CTD PMID:24845367 NCBI chr 6:151,654,148...152,129,619
Ensembl chr 6:151,656,691...152,129,619
JBrowse link
G EXOC6 exocyst complex component 6 decreases expression EXP Manganese results in decreased expression of EXOC6 mRNA CTD PMID:17175027 NCBI chr10:92,826,831...93,059,490
Ensembl chr10:92,826,831...93,059,493
JBrowse link
G EYA4 EYA transcriptional coactivator and phosphatase 4 decreases expression EXP Manganese results in decreased expression of EYA4 mRNA CTD PMID:17175027 NCBI chr 6:133,240,340...133,532,128
Ensembl chr 6:133,240,514...133,532,128
JBrowse link
G F2 coagulation factor II, thrombin multiple interactions
increases uptake
EXP 1-Methyl-3-isobutylxanthine inhibits the reaction [F2 protein results in increased uptake of Manganese]; Colforsin inhibits the reaction [F2 protein results in increased uptake of Manganese]; Nickel inhibits the reaction [F2 protein results in increased uptake of Manganese]; Tetradecanoylphorbol Acetate inhibits the reaction [F2 protein results in increased uptake of Manganese] CTD PMID:2125206 NCBI chr11:46,719,213...46,739,506
Ensembl chr11:46,719,196...46,739,506
JBrowse link
G FA2H fatty acid 2-hydroxylase increases expression ISO Manganese results in increased expression of FA2H mRNA CTD PMID:26745496 NCBI chr16:74,712,955...74,774,831
Ensembl chr16:74,712,955...74,774,831
JBrowse link
G FAM107A family with sequence similarity 107 member A decreases expression ISO Manganese results in decreased expression of FAM107A mRNA CTD PMID:26745496 NCBI chr 3:58,564,117...58,627,610
Ensembl chr 3:58,564,117...58,627,610
JBrowse link
G FAM180A family with sequence similarity 180 member A decreases expression ISO Manganese results in decreased expression of FAM180A mRNA CTD PMID:26745496 NCBI chr 7:135,729,592...135,748,813
Ensembl chr 7:135,728,348...135,748,813
JBrowse link
G FANCF FA complementation group F decreases expression EXP Manganese results in decreased expression of FANCF mRNA CTD PMID:17175027 NCBI chr11:22,622,533...22,625,823
Ensembl chr11:22,622,533...22,625,823
JBrowse link
G FCGR1A Fc gamma receptor Ia decreases expression ISO Manganese results in decreased expression of FCGR1A mRNA CTD PMID:26745496 NCBI chr 1:149,782,694...149,800,609
Ensembl chr 1:149,782,671...149,791,675
JBrowse link
G FGFBP1 fibroblast growth factor binding protein 1 decreases expression ISO Manganese results in decreased expression of FGFBP1 mRNA CTD PMID:26745496 NCBI chr 4:15,935,577...15,938,740
Ensembl chr 4:15,935,577...15,938,740
JBrowse link
G FHL1 four and a half LIM domains 1 decreases expression EXP Manganese results in decreased expression of FHL1 mRNA CTD PMID:17175027 NCBI chr  X:136,146,702...136,211,359
Ensembl chr  X:136,146,702...136,211,359
JBrowse link
G FIBIN fin bud initiation factor homolog increases expression ISO Manganese results in increased expression of FIBIN mRNA CTD PMID:21615908 NCBI chr11:26,994,112...26,997,087
Ensembl chr11:26,994,112...26,997,087
JBrowse link
G FLCN folliculin increases expression EXP Manganese results in increased expression of FLCN mRNA CTD PMID:17175027 NCBI chr17:17,206,946...17,237,188
Ensembl chr17:17,212,212...17,237,188
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO
EXP
[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of [JUN protein binds to FOS protein]]; Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS protein]
Manganese results in decreased expression of FOS protein
CTD PMID:17043766 PMID:17827730 PMID:22561169 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G FOXN4 forkhead box N4 increases expression ISO Manganese results in increased expression of FOXN4 mRNA CTD PMID:26745496 NCBI chr12:109,277,978...109,309,406
Ensembl chr12:109,277,978...109,309,284
JBrowse link
G FOXO3 forkhead box O3 multiple interactions
affects localization
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein]; 2-oxothiazolidine-4-carboxylic acid inhibits the reaction [Manganese affects the localization of FOXO3 protein]; 2-oxothiazolidine-4-carboxylic acid inhibits the reaction [Manganese results in increased expression of FOXO3 protein]; Manganese results in increased expression of and results in increased phosphorylation of FOXO3 protein; SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein] CTD PMID:24787138 NCBI chr 6:108,559,825...108,684,774
Ensembl chr 6:108,559,835...108,684,774
JBrowse link
G FOXP2 forkhead box P2 increases expression EXP Manganese results in increased expression of FOXP2 mRNA CTD PMID:17175027 NCBI chr 7:114,086,327...114,693,765
Ensembl chr 7:114,086,327...114,693,772
JBrowse link
G FTH1 ferritin heavy chain 1 decreases expression
increases expression
ISO Manganese results in decreased expression of FTH1 mRNA; Manganese results in decreased expression of FTH1 protein
Manganese results in increased expression of FTH1 protein
CTD PMID:16545456 PMID:16568477 PMID:16740617 PMID:17469137 NCBI chr11:61,964,285...61,967,634
Ensembl chr11:61,959,718...61,967,634
JBrowse link
G FXYD2 FXYD domain containing ion transport regulator 2 increases expression EXP Manganese results in increased expression of FXYD2 mRNA CTD PMID:17175027 NCBI chr11:117,820,057...117,828,089
Ensembl chr11:117,800,844...117,828,698
JBrowse link
G GABBR2 gamma-aminobutyric acid type B receptor subunit 2 multiple interactions EXP [manganese chloride results in increased abundance of Manganese] which results in increased expression of GABBR2 protein CTD PMID:32659473 NCBI chr 9:98,288,104...98,708,935
Ensembl chr 9:98,288,109...98,708,935
JBrowse link
G GABRA1 gamma-aminobutyric acid type A receptor subunit alpha1 multiple interactions EXP [manganese chloride results in increased abundance of Manganese] which results in decreased expression of GABRA1 protein CTD PMID:32659473 NCBI chr 5:161,847,191...161,899,971
Ensembl chr 5:161,847,063...161,899,981
JBrowse link
G GABRG2 gamma-aminobutyric acid type A receptor subunit gamma2 increases expression EXP Manganese results in increased expression of GABRG2 mRNA CTD PMID:17175027 NCBI chr 5:162,067,465...162,155,539
Ensembl chr 5:162,000,057...162,162,977
JBrowse link
G GADD45A growth arrest and DNA damage inducible alpha increases expression ISO Manganese results in increased expression of GADD45A mRNA CTD PMID:23499988 NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334
JBrowse link
G GAL galanin and GMAP prepropeptide increases expression EXP Manganese results in increased expression of GAL mRNA CTD PMID:17175027 NCBI chr11:68,684,544...68,691,175
Ensembl chr11:68,683,779...68,691,175
JBrowse link
G GCFC2 GC-rich sequence DNA-binding factor 2 decreases expression EXP Manganese results in decreased expression of GCFC2 mRNA CTD PMID:17175027 NCBI chr 2:75,655,606...75,711,642
Ensembl chr 2:75,652,000...75,710,985
JBrowse link
G GDAP2 ganglioside induced differentiation associated protein 2 increases expression EXP Manganese results in increased expression of GDAP2 mRNA CTD PMID:17175027 NCBI chr 1:117,863,485...117,929,621
Ensembl chr 1:117,863,485...117,929,621
JBrowse link
G GDF15 growth differentiation factor 15 increases expression EXP Manganese results in increased expression of GDF15 mRNA CTD PMID:17175027 NCBI chr19:18,382,170...18,389,176
Ensembl chr19:18,374,731...18,389,176
JBrowse link
G GFAP glial fibrillary acidic protein decreases expression
affects expression
increases expression
ISO Manganese results in decreased expression of GFAP mRNA
Manganese affects the expression of GFAP protein
Manganese results in increased expression of GFAP mRNA; Manganese results in increased expression of GFAP protein
CTD PMID:19782702 PMID:20224926 PMID:23832297 PMID:24885898 NCBI chr17:44,903,159...44,915,552
Ensembl chr17:44,903,159...44,916,937
JBrowse link
G GJA5 gap junction protein alpha 5 decreases expression ISO Manganese results in decreased expression of GJA5 mRNA CTD PMID:26745496 NCBI chr 1:147,756,199...147,773,351
Ensembl chr 1:147,756,199...147,773,362
JBrowse link
G GLDN gliomedin decreases expression ISO Manganese results in decreased expression of GLDN mRNA CTD PMID:26745496 NCBI chr15:51,341,655...51,413,365
Ensembl chr15:51,341,655...51,408,005
JBrowse link
G GLUD1 glutamate dehydrogenase 1 decreases expression
multiple interactions
ISO Manganese deficiency results in decreased expression of GLUD1 protein
Paroxetine inhibits the reaction [Manganese deficiency results in decreased expression of GLUD1 protein]
CTD PMID:21312047 NCBI chr10:87,050,202...87,094,843
Ensembl chr10:87,050,202...87,094,843
JBrowse link
G GLUL glutamate-ammonia ligase affects expression
decreases expression
ISO Manganese affects the expression of GLUL mRNA; Manganese affects the expression of GLUL protein
Manganese results in decreased expression of GLUL mRNA; Manganese results in decreased expression of GLUL protein
CTD PMID:16842851 PMID:16943606 NCBI chr 1:182,378,098...182,391,790
Ensembl chr 1:182,378,098...182,392,206
JBrowse link
G GNRH1 gonadotropin releasing hormone 1 increases expression ISO Manganese results in increased expression of GNRH1 mRNA CTD PMID:23997110 NCBI chr 8:25,419,258...25,425,040
Ensembl chr 8:25,419,258...25,424,654
JBrowse link
G GPER1 G protein-coupled estrogen receptor 1 multiple interactions ISO [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in decreased susceptibility to Manganese CTD PMID:22645130 NCBI chr 7:1,087,118...1,093,810
Ensembl chr 7:1,082,208...1,093,815
JBrowse link
G GPR18 G protein-coupled receptor 18 decreases expression ISO Manganese results in decreased expression of GPR18 mRNA CTD PMID:26745496 NCBI chr13:99,254,713...99,262,498
Ensembl chr13:99,254,732...99,261,744
JBrowse link
G GPR34 G protein-coupled receptor 34 decreases expression ISO Manganese results in decreased expression of GPR34 mRNA CTD PMID:26745496 NCBI chr  X:41,686,397...41,697,275
Ensembl chr  X:41,688,973...41,697,275
JBrowse link
G GRIN1 glutamate ionotropic receptor NMDA type subunit 1 decreases expression ISO Manganese results in decreased expression of GRIN1 mRNA; Manganese results in decreased expression of GRIN1 protein CTD PMID:19643132 PMID:29205667 NCBI chr 9:137,139,092...137,168,759
Ensembl chr 9:137,139,154...137,168,756
JBrowse link
G GRIN2A glutamate ionotropic receptor NMDA type subunit 2A decreases expression ISO Manganese results in decreased expression of GRIN2A mRNA; Manganese results in decreased expression of GRIN2A protein CTD PMID:19643132 PMID:29205667 NCBI chr16:9,753,404...10,182,928
Ensembl chr16:9,753,404...10,182,928
JBrowse link
G GRIN2B glutamate ionotropic receptor NMDA type subunit 2B decreases expression ISO Manganese results in decreased expression of GRIN2B mRNA; Manganese results in decreased expression of GRIN2B protein CTD PMID:19643132 PMID:29205667 NCBI chr12:13,537,337...13,982,012
Ensembl chr12:13,437,942...13,982,002
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G GSR glutathione-disulfide reductase decreases expression
multiple interactions
EXP
ISO
Manganese results in decreased expression of GSR mRNA
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of GSR protein
[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of GSR protein
CTD PMID:17175027 PMID:17176674 PMID:32445656 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
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G GSTP1 glutathione S-transferase pi 1 affects response to substance EXP GSTP1 gene polymorphism affects the susceptibility to Manganese CTD PMID:30930959 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
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G GTF2H1 general transcription factor IIH subunit 1 decreases expression EXP Manganese results in decreased expression of GTF2H1 mRNA CTD PMID:17175027 NCBI chr11:18,322,567...18,367,045
Ensembl chr11:18,322,295...18,367,045
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G GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions EXP Manganese results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 4:155,666,725...155,737,059
Ensembl chr 4:155,666,726...155,737,059
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G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions EXP Manganese results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein] CTD PMID:22171090 NCBI chr 4:155,759,021...155,807,811
Ensembl chr 4:155,758,992...155,807,811
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G HAMP hepcidin antimicrobial peptide decreases expression ISO Manganese results in decreased expression of HAMP mRNA CTD PMID:29020610 NCBI chr19:35,282,528...35,285,143
Ensembl chr19:35,280,716...35,285,143
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G HDAC1 histone deacetylase 1 multiple interactions ISO Manganese promotes the reaction [RELA protein binds to HDAC1 protein]; Manganese promotes the reaction [YY1 protein binds to HDAC1 protein] CTD PMID:24469401 NCBI chr 1:32,292,083...32,333,628
Ensembl chr 1:32,292,083...32,333,635
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G HEPH hephaestin increases expression EXP Manganese results in increased expression of HEPH mRNA CTD PMID:17175027 NCBI chr  X:66,162,526...66,268,863
Ensembl chr  X:66,162,671...66,268,867
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G HFE homeostatic iron regulator affects abundance ISO HFE protein affects the abundance of Manganese CTD PMID:18317567 NCBI chr 6:26,087,347...26,098,343
Ensembl chr 6:26,087,281...26,098,343
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G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
EXP Manganese results in increased expression of and results in increased activity of HIF1A protein
Manganese results in increased expression of HIF1A mRNA
CTD PMID:16386771 PMID:17175027 NCBI chr14:61,695,513...61,748,258
Ensembl chr14:61,695,513...61,748,259
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G HIF1AN hypoxia inducible factor 1 subunit alpha inhibitor decreases expression EXP Manganese results in decreased expression of HIF1AN mRNA CTD PMID:17175027 NCBI chr10:100,535,921...100,559,998
Ensembl chr10:100,529,072...100,559,998
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G HLA-DRB4 major histocompatibility complex, class II, DR beta 4 increases expression EXP Manganese results in increased expression of HLA-DRB4 mRNA CTD PMID:17175027
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
increases activity
ISO [Manganese co-treated with Bilirubin] results in decreased activity of HMGCR protein
Manganese results in increased activity of HMGCR protein
CTD PMID:12700418 NCBI chr 5:75,336,334...75,362,116
Ensembl chr 5:75,336,329...75,364,001
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G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO Manganese results in decreased expression of HMGCS2 mRNA CTD PMID:26745496 NCBI chr 1:119,747,996...119,768,932
Ensembl chr 1:119,748,002...119,768,905
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G HMOX1 heme oxygenase 1 increases expression
multiple interactions
EXP
ISO
Manganese results in increased expression of HMOX1 mRNA
[manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein]
CTD PMID:11181820 PMID:18948096 PMID:2