CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: alicyclic compound
Accession: CHEBI:33654
browse the term
Definition: An aliphatic compound having a carbocyclic ring structure which may be saturated or unsaturated, but may not be a benzenoid or other aromatic system.
Synonyms: exact_synonym: alicyclic compounds
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Acaca
acetyl-CoA carboxylase alpha
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of ACACA mRNA
CTD
PMID:38000518
NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,014,170...69,276,457
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Acacb
acetyl-CoA carboxylase beta
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of ACACB mRNA
CTD
PMID:38000518
NCBI chr12:48,026,394...48,138,214
Ensembl chr12:42,366,548...42,457,655
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Acly
ATP citrate lyase
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of ACLY mRNA
CTD
PMID:38000518
NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,412,049...85,463,320
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Acta2
actin alpha 2, smooth muscle
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of ACTA2 mRNA
CTD
PMID:38000518
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of AHR mRNA
CTD
PMID:38000518
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of AKT1 mRNA
CTD
PMID:38000518
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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Cat
catalase
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of CAT mRNA
CTD
PMID:38000518
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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Ccn2
cellular communication network factor 2
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of CTGF mRNA
CTD
PMID:38000518
NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734
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Chrna7
cholinergic receptor nicotinic alpha 7 subunit
multiple interactions
ISO
beta-thujone inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; beta-thujone inhibits the reaction [Choline results in increased activity of CHRNA7 protein]
CTD
PMID:28395994
NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
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Col1a1
collagen type I alpha 1 chain
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of COL1A1 mRNA
CTD
PMID:38000518
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
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Cpt1a
carnitine palmitoyltransferase 1A
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of CPT1A mRNA
CTD
PMID:38000518
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055
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Cpt2
carnitine palmitoyltransferase 2
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of CPT2 mRNA
CTD
PMID:38000518
NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:122,664,677...122,682,095
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of CYP1A1 mRNA
CTD
PMID:38000518
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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Dgat1
diacylglycerol O-acyltransferase 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of DGAT1 mRNA
CTD
PMID:38000518
NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:108,218,524...108,234,299
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Fasn
fatty acid synthase
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of FASN mRNA
CTD
PMID:38000518
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
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Foxo1
forkhead box O1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of FOXO1 mRNA
CTD
PMID:38000518
NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
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Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
multiple interactions
ISO
beta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:15588619
NCBI chr10:27,096,731...27,152,563
Ensembl chr10:26,595,160...26,650,864
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Gabrb2
gamma-aminobutyric acid type A receptor subunit beta 2
multiple interactions
ISO
beta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:15588619
NCBI chr10:27,438,127...27,657,680
Ensembl chr10:26,936,551...27,151,251
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Gabrg2
gamma-aminobutyric acid type A receptor subunit gamma 2
multiple interactions
ISO
beta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:15588619
NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,374,694...26,464,346
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Gpx1
glutathione peroxidase 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of GPX1 mRNA
CTD
PMID:38000518
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
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Gsr
glutathione-disulfide reductase
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of GSR mRNA
CTD
PMID:38000518
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
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Mlycd
malonyl-CoA decarboxylase
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of MLYCD mRNA
CTD
PMID:38000518
NCBI chr19:64,356,582...64,372,447
Ensembl chr19:47,447,970...47,463,793
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Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of NFE2L2 mRNA
CTD
PMID:38000518
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of NFKB1 mRNA
CTD
PMID:38000518
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of PPARA mRNA
CTD
PMID:38000518
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
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Ptgs1
prostaglandin-endoperoxide synthase 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of PTGS1 mRNA
CTD
PMID:38000518
NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:19,584,015...19,605,586
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Snai1
snail family transcriptional repressor 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of SNAI1 mRNA
CTD
PMID:38000518
NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969
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Sod1
superoxide dismutase 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of SOD1 mRNA
CTD
PMID:38000518
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
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Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of TGFB1 mRNA
CTD
PMID:38000518
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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Zeb1
zinc finger E-box binding homeobox 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of ZEB1 mRNA
CTD
PMID:38000518
NCBI chr17:56,644,397...56,811,155
Ensembl chr17:51,948,948...52,115,214
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Zeb2
zinc finger E-box binding homeobox 2
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of ZEB2 mRNA
CTD
PMID:38000518
NCBI chr 3:49,624,028...49,754,323
Ensembl chr 3:29,218,301...29,345,157
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Aatf
apoptosis antagonizing transcription factor
decreases expression
ISO
alpha phellandrene results in decreased expression of AATF mRNA
CTD
PMID:25075043
NCBI chr10:69,796,502...69,889,671
Ensembl chr10:69,299,037...69,392,201
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Acp1
acid phosphatase 1
decreases expression
ISO
alpha phellandrene results in decreased expression of ACP1 mRNA
CTD
PMID:25075043
NCBI chr 6:53,233,937...53,249,576
Ensembl chr 6:47,506,380...47,522,021
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Acss2
acyl-CoA synthetase short-chain family member 2
increases expression
ISO
alpha phellandrene results in increased expression of ACSS2 mRNA
CTD
PMID:25075043
NCBI chr 3:164,464,124...164,507,607
Ensembl chr 3:144,004,336...144,059,675
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Adam18
ADAM metallopeptidase domain 18
decreases expression
ISO
alpha phellandrene results in decreased expression of ADAM18 mRNA
CTD
PMID:25075043
NCBI chr16:74,054,974...74,127,861
Ensembl chr16:67,352,416...67,425,248
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Adam3a
ADAM metallopeptidase domain 3A
decreases expression
ISO
alpha phellandrene results in decreased expression of ADAM3 mRNA
CTD
PMID:25075043
NCBI chr16:74,002,566...74,052,579
Ensembl chr16:67,299,949...67,349,968
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Afg2a
AFG2 AAA ATPase homolog A
decreases expression
ISO
alpha phellandrene results in decreased expression of AFG2A mRNA
CTD
PMID:25075043
NCBI chr 2:122,234,619...122,425,808
Ensembl chr 2:120,306,412...120,497,705
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Akt1
AKT serine/threonine kinase 1
decreases expression
ISO
alpha phellandrene results in decreased expression of AKT1 protein
CTD
PMID:25649747
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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Aldh1l2
aldehyde dehydrogenase 1 family, member L2
increases expression
ISO
alpha phellandrene results in increased expression of ALDH1L2 mRNA
CTD
PMID:25075043
NCBI chr 7:22,141,872...22,193,403
Ensembl chr 7:20,254,233...20,305,776
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Aldoc
aldolase, fructose-bisphosphate C
increases expression
ISO
alpha phellandrene results in increased expression of ALDOC mRNA
CTD
PMID:25075043
NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,217,451...63,221,066
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Ankrd49
ankyrin repeat domain 49
decreases expression
ISO
alpha phellandrene results in decreased expression of ANKRD49 mRNA
CTD
PMID:25075043
NCBI chr 8:19,908,968...19,913,656
Ensembl chr 8:11,627,518...11,632,207
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Anxa1
annexin A1
increases expression
ISO
alpha phellandrene results in increased expression of ANXA1 mRNA
CTD
PMID:25075043
NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:217,861,175...217,877,343
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Anxa9
annexin A9
decreases expression
ISO
alpha phellandrene results in decreased expression of ANXA9 mRNA
CTD
PMID:25075043
NCBI chr 2:185,562,174...185,572,560
Ensembl chr 2:182,872,929...182,883,374
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Ap3m2
adaptor related protein complex 3 subunit mu 2
increases expression
ISO
alpha phellandrene results in increased expression of AP3M2 mRNA
CTD
PMID:25075043
NCBI chr16:75,908,459...75,937,915
Ensembl chr16:69,217,633...69,235,431
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Arg2
arginase 2
increases expression
ISO
alpha phellandrene results in increased expression of ARG2 mRNA
CTD
PMID:25075043
NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:97,936,002...97,961,378
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Arhgef12
Rho guanine nucleotide exchange factor 12
increases expression
ISO
alpha phellandrene results in increased expression of ARHGEF12 mRNA
CTD
PMID:25075043
NCBI chr 8:52,247,047...52,373,158
Ensembl chr 8:43,353,799...43,476,366
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Arsk
arylsulfatase family, member K
decreases expression
ISO
alpha phellandrene results in decreased expression of ARSK mRNA
CTD
PMID:25075043
NCBI chr 2:7,306,181...7,363,311
Ensembl chr 2:5,574,322...5,631,467
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Aspa
aspartoacylase
increases expression
ISO
alpha phellandrene results in increased expression of ASPA mRNA
CTD
PMID:25075043
NCBI chr10:58,390,204...58,443,790
Ensembl chr10:57,892,104...57,945,272
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Atf3
activating transcription factor 3
increases expression
ISO
alpha phellandrene results in increased expression of ATF3 mRNA
CTD
PMID:25075043
NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631
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Bcl2
BCL2, apoptosis regulator
increases phosphorylation
ISO
alpha phellandrene results in increased phosphorylation of BCL2 protein
CTD
PMID:25649747
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Becn1
beclin 1
increases phosphorylation
ISO
alpha phellandrene results in increased phosphorylation of BECN1 protein
CTD
PMID:25649747
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742
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Bmf
Bcl2 modifying factor
increases expression
ISO
alpha phellandrene results in increased expression of BMF mRNA
CTD
PMID:25075043
NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:105,499,538...105,520,145
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Bnip3
BCL2 interacting protein 3
increases expression
ISO
alpha phellandrene results in increased expression of BNIP3 mRNA
CTD
PMID:25075043
NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359
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Bod1
biorientation of chromosomes in cell division 1
increases expression
ISO
alpha phellandrene results in increased expression of BOD1 mRNA
CTD
PMID:25075043
NCBI chr10:16,497,918...16,504,259
Ensembl chr10:15,993,454...15,999,787
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Brca1
BRCA1, DNA repair associated
decreases expression
ISO
alpha phellandrene results in decreased expression of BRCA1 protein
CTD
PMID:24861204
NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,418,000...86,477,304
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Btg2
BTG anti-proliferation factor 2
increases expression
ISO
alpha phellandrene results in increased expression of BTG2 mRNA
CTD
PMID:25075043
NCBI chr13:48,083,931...48,087,690
Ensembl chr13:45,531,925...45,535,628
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Calm2
calmodulin 2
increases expression
ISO
alpha phellandrene results in increased expression of CALM2 mRNA
CTD
PMID:25075043
NCBI chr 6:12,845,170...12,857,830
Ensembl chr 6:7,091,567...7,104,287 Ensembl chr15:7,091,567...7,104,287
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Capns1
calpain, small subunit 1
increases expression
ISO
alpha phellandrene results in increased expression of CAPNS1 mRNA
CTD
PMID:25075043
NCBI chr 1:94,572,083...94,582,332
Ensembl chr 1:85,444,608...85,454,795
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Caprin2
caprin family member 2
increases expression
ISO
alpha phellandrene results in increased expression of CAPRIN2 mRNA
CTD
PMID:25075043
NCBI chr 4:183,537,935...183,592,162
Ensembl chr 4:181,806,575...181,860,830
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Card6
caspase recruitment domain family, member 6
increases expression
ISO
alpha phellandrene results in increased expression of CARD6 mRNA
CTD
PMID:25075043
NCBI chr 2:55,921,832...55,934,388
Ensembl chr 2:54,195,739...54,206,846
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Carhsp1
calcium regulated heat stable protein 1
increases expression
ISO
alpha phellandrene results in increased expression of CARHSP1 mRNA
CTD
PMID:25075043
NCBI chr10:7,453,602...7,467,218
Ensembl chr10:6,946,959...7,020,019
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Ccl5
C-C motif chemokine ligand 5
increases expression
ISO
alpha phellandrene results in increased expression of CCL5 mRNA
CTD
PMID:25075043
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
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Ccng2
cyclin G2
increases expression
ISO
alpha phellandrene results in increased expression of CCNG2 mRNA
CTD
PMID:25075043
NCBI chr14:15,088,694...15,097,190
Ensembl chr14:14,804,322...14,812,830
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Ccrl2
C-C motif chemokine receptor like 2
increases expression
ISO
alpha phellandrene results in increased expression of CCRL2 mRNA
CTD
PMID:25075043
NCBI chr 8:119,912,671...119,915,313
Ensembl chr 8:111,034,279...111,036,664
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Cd59b
CD59b molecule
decreases expression
ISO
alpha phellandrene results in decreased expression of CD59A mRNA
CTD
PMID:25075043
NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847
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Cdcp2
CUB domain containing protein 2
increases expression
ISO
alpha phellandrene results in increased expression of CDCP2 mRNA
CTD
PMID:25075043
NCBI chr 5:127,106,380...127,124,243
Ensembl chr 5:121,877,581...121,894,203
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
alpha phellandrene results in increased expression of CDKN1A mRNA
CTD
PMID:25075043
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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Cdkn2d
cyclin dependent kinase inhibitor 2D
increases expression
ISO
alpha phellandrene results in increased expression of CDKN2D mRNA
CTD
PMID:25075043
NCBI chr 8:28,108,036...28,110,809
Ensembl chr 8:19,831,866...19,834,674
G
Cflar
CASP8 and FADD-like apoptosis regulator
increases expression
ISO
alpha phellandrene results in increased expression of CFLAR mRNA
CTD
PMID:25075043
NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034
G
Clec12a
C-type lectin domain family 12, member A
decreases expression
ISO
alpha phellandrene results in decreased expression of CLEC12A mRNA
CTD
PMID:25075043
NCBI chr 4:164,484,162...164,502,793
Ensembl chr 4:162,798,125...162,816,753
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Clec4d
C-type lectin domain family 4, member D
decreases expression
ISO
alpha phellandrene results in decreased expression of CLEC4D mRNA
CTD
PMID:25075043
NCBI chr 4:158,275,287...158,286,978
Ensembl chr 4:156,589,792...156,598,848
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Clec6a-ps1
C-type lectin domain family 6, member A, pseudogene 1
decreases expression
ISO
alpha phellandrene results in decreased expression of CLEC4N mRNA
CTD
PMID:25075043
NCBI chr 4:158,225,100...158,244,722
Ensembl chr 4:156,539,408...156,558,605 Ensembl chr 4:156,539,408...156,558,605
G
Cluh
clustered mitochondria homolog
decreases expression
ISO
alpha phellandrene results in decreased expression of CLUH mRNA
CTD
PMID:25075043
NCBI chr10:60,008,052...60,029,742
Ensembl chr10:59,509,726...59,531,345
G
Cmpk2
cytidine/uridine monophosphate kinase 2
increases expression
ISO
alpha phellandrene results in increased expression of CMPK2 mRNA
CTD
PMID:25075043
NCBI chr 6:48,802,150...48,813,652
Ensembl chr 6:43,073,796...43,085,183
G
Cr1l
complement C3b/C4b receptor 1 like
decreases expression
ISO
alpha phellandrene results in decreased expression of CR1L mRNA
CTD
PMID:25075043
NCBI chr13:109,138,132...109,189,068
Ensembl chr13:106,574,858...106,660,445
G
Crisp1
cysteine-rich secretory protein 1
decreases expression
ISO
alpha phellandrene results in decreased expression of CRISP1 mRNA
CTD
PMID:25075043
NCBI chr 9:28,238,326...28,265,344
Ensembl chr 9:20,741,777...20,768,796
G
Cst7
cystatin F
decreases expression
ISO
alpha phellandrene results in decreased expression of CST7 mRNA
CTD
PMID:25075043
NCBI chr 3:159,857,221...159,865,987
Ensembl chr 3:139,396,850...139,405,557
G
Csta
cystatin A
increases expression
ISO
alpha phellandrene results in increased expression of STFA1 mRNA
CTD
PMID:25075043
NCBI chr11:78,125,813...78,136,818
Ensembl chr11:64,620,483...64,631,488
G
Ctsg
cathepsin G
decreases expression
ISO
alpha phellandrene results in decreased expression of CTSG mRNA
CTD
PMID:25075043
NCBI chr15:33,901,230...33,907,596
Ensembl chr15:29,931,003...29,937,353
G
Cxcl10
C-X-C motif chemokine ligand 10
increases expression
ISO
alpha phellandrene results in increased expression of CXCL10 mRNA
CTD
PMID:25075043
NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975
G
Cyb561d2
cytochrome b561 family, member D2
decreases expression
ISO
alpha phellandrene results in decreased expression of CYB561D2 mRNA
CTD
PMID:25075043
NCBI chr 8:117,091,844...117,094,434
Ensembl chr 8:108,213,205...108,215,759
G
Cyfip2
cytoplasmic FMR1 interacting protein 2
increases expression
ISO
alpha phellandrene results in increased expression of CYFIP2 mRNA
CTD
PMID:25075043
NCBI chr10:31,122,653...31,242,440
Ensembl chr10:30,621,318...30,741,113
G
Cyp51
cytochrome P450, family 51
decreases expression
ISO
alpha phellandrene results in decreased expression of CYP51 mRNA
CTD
PMID:25075043
NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,036,865...30,055,410 Ensembl chr 6:30,036,865...30,055,410
G
Dbx1
developing brain homeobox 1
increases expression
ISO
alpha phellandrene results in increased expression of DBX1 mRNA
CTD
PMID:25075043
NCBI chr 1:108,484,846...108,490,381
Ensembl chr 1:99,349,608...99,354,038
G
Dctd
dCMP deaminase
decreases expression
ISO
alpha phellandrene results in decreased expression of DCTD mRNA
CTD
PMID:25075043
NCBI chr16:50,799,699...50,831,398
Ensembl chr16:44,055,128...44,098,446
G
Ddit4
DNA-damage-inducible transcript 4
increases expression
ISO
alpha phellandrene results in increased expression of DDIT4 mRNA
CTD
PMID:25075043
NCBI chr20:28,434,938...28,437,037
Ensembl chr20:27,891,998...27,894,105
G
Ddx31
DEAD-box helicase 31
decreases expression
ISO
alpha phellandrene results in decreased expression of DDX31 mRNA
CTD
PMID:25075043
NCBI chr 3:32,570,725...32,635,446
Ensembl chr 3:12,172,836...12,238,873
G
Ddx60
DEXD/H-box helicase 60
increases expression
ISO
alpha phellandrene results in increased expression of DDX60 mRNA
CTD
PMID:25075043
NCBI chr16:33,087,940...33,208,843
Ensembl chr16:28,076,999...28,179,526
G
Dffb
DNA fragmentation factor subunit beta
increases expression
ISO
alpha phellandrene results in increased expression of DFFB mRNA
CTD
PMID:25075043
NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:164,522,463...164,534,628
G
Dgka
diacylglycerol kinase, alpha
increases expression
ISO
alpha phellandrene results in increased expression of DGKA mRNA
CTD
PMID:25075043
NCBI chr 7:1,733,247...1,761,181
Ensembl chr 7:1,148,735...1,175,110
G
Dhrs1
dehydrogenase/reductase 1
increases expression
ISO
alpha phellandrene results in increased expression of DHRS1 mRNA
CTD
PMID:25075043
NCBI chr15:33,206,449...33,213,776
Ensembl chr15:29,236,522...29,243,838
G
Dhx33
DEAH-box helicase 33
decreases expression
ISO
alpha phellandrene results in decreased expression of DHX33 mRNA
CTD
PMID:25075043
NCBI chr10:56,206,680...56,223,189
Ensembl chr10:55,705,756...55,724,567
G
Dhx58
DEXH-box helicase 58
increases expression
ISO
alpha phellandrene results in increased expression of DHX58 mRNA
CTD
PMID:25075043
NCBI chr10:86,120,677...86,132,095
Ensembl chr10:85,620,357...85,631,525
G
Dkc1
dyskerin pseudouridine synthase 1
decreases expression
ISO
alpha phellandrene results in decreased expression of DKC1 mRNA
CTD
PMID:25075043
NCBI chr X:157,751,651...157,757,796
G
Dusp1
dual specificity phosphatase 1
increases expression
ISO
alpha phellandrene results in increased expression of DUSP1 mRNA
CTD
PMID:25075043
NCBI chr10:17,184,853...17,187,646
G
Dusp6
dual specificity phosphatase 6
increases expression
ISO
alpha phellandrene results in increased expression of DUSP6 mRNA
CTD
PMID:25075043
NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:34,092,943...34,097,185
G
Dynlt3
dynein light chain Tctex-type 3
increases expression
ISO
alpha phellandrene results in increased expression of DYNLT3 mRNA
CTD
PMID:25075043
NCBI chr X:16,000,425...16,009,632
Ensembl chr X:13,327,892...13,337,139
G
Egln3
egl-9 family hypoxia-inducible factor 3
increases expression
ISO
alpha phellandrene results in increased expression of EGLN3 mRNA
CTD
PMID:25075043
NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:71,650,297...71,675,766
G
Egr1
early growth response 1
increases expression
ISO
alpha phellandrene results in increased expression of EGR1 mRNA
CTD
PMID:25075043
NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766
G
Eif5
eukaryotic translation initiation factor 5
decreases expression
ISO
alpha phellandrene results in decreased expression of EIF5 mRNA
CTD
PMID:25075043
NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:130,589,143...130,597,656
G
Elac2
elaC ribonuclease Z 2
decreases expression
ISO
alpha phellandrene results in decreased expression of ELAC2 mRNA
CTD
PMID:25075043
NCBI chr10:50,131,449...50,154,755
Ensembl chr10:49,632,378...49,655,614
G
Elovl1
ELOVL fatty acid elongase 1
decreases expression
ISO
alpha phellandrene results in decreased expression of ELOVL1 mRNA
CTD
PMID:25075043
NCBI chr 5:137,246,781...137,251,351
Ensembl chr 5:131,961,322...131,965,958
G
Elovl7
ELOVL fatty acid elongase 7
increases expression
ISO
alpha phellandrene results in increased expression of ELOVL7 mRNA
CTD
PMID:25075043
NCBI chr 2:41,522,695...41,592,021
Ensembl chr 2:39,789,250...39,856,845
G
Eno2
enolase 2
increases expression
ISO
alpha phellandrene results in increased expression of ENO2 mRNA
CTD
PMID:25075043
NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:157,572,088...157,580,980
G
Fbxo44
F-box protein 44
increases expression
ISO
alpha phellandrene results in increased expression of FBXO44 mRNA
CTD
PMID:25075043
NCBI chr 5:163,866,517...163,875,928
Ensembl chr 5:158,583,366...158,592,363
G
Fggy
FGGY carbohydrate kinase domain containing
increases expression
ISO
alpha phellandrene results in increased expression of FGGY mRNA
CTD
PMID:25075043
NCBI chr 5:115,514,573...115,901,713
Ensembl chr 5:110,398,863...110,786,017
G
Flvcr1
FLVCR choline and heme transporter 1
decreases expression
ISO
alpha phellandrene results in decreased expression of FLVCR1 mRNA
CTD
PMID:25075043
NCBI chr13:105,117,402...105,139,780
Ensembl chr13:102,586,257...102,608,661
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
alpha phellandrene results in increased expression of FOS mRNA
CTD
PMID:25075043
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
G
Foxo1
forkhead box O1
increases expression
ISO
alpha phellandrene results in increased expression of FOXO1 mRNA
CTD
PMID:25075043
NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
G
Fpr1
formyl peptide receptor 1
decreases expression
ISO
alpha phellandrene results in decreased expression of FPR1 mRNA
CTD
PMID:25075043
NCBI chr 1:67,417,991...67,429,813
Ensembl chr 1:58,747,246...58,756,559
G
Fth1
ferritin heavy chain 1
increases expression
ISO
alpha phellandrene results in increased expression of FTH1 mRNA
CTD
PMID:25075043
NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424
G
Ftl1
ferritin light chain 1
increases expression
ISO
alpha phellandrene results in increased expression of FTL1 mRNA; alpha phellandrene results in increased expression of FTL2-PS mRNA
CTD
PMID:25075043
NCBI chr 1:105,072,858...105,074,705
Ensembl chr 2:61,543,323...61,578,556 Ensembl chr10:61,543,323...61,578,556 Ensembl chr 1:61,543,323...61,578,556
G
Ftsj3
FtsJ RNA 2'-O-methyltransferase 3
decreases expression
ISO
alpha phellandrene results in decreased expression of FTSJ3 mRNA
CTD
PMID:25075043
NCBI chr10:91,680,735...91,687,475
Ensembl chr10:91,180,696...91,187,397
G
Fxn
frataxin
decreases expression
ISO
alpha phellandrene results in decreased expression of FXN mRNA
CTD
PMID:25075043
NCBI chr 1:231,300,457...231,323,989
Ensembl chr 1:221,872,420...221,897,540
G
Gabarap
GABA type A receptor-associated protein
increases expression
ISO
alpha phellandrene results in increased expression of GABARAP mRNA
CTD
PMID:25075043
NCBI chr10:55,213,465...55,216,787
Ensembl chr10:54,714,198...54,717,765
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
alpha phellandrene results in increased expression of GADD45A mRNA
CTD
PMID:25075043
NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115
G
Gas5
growth arrest specific 5
decreases expression
ISO
alpha phellandrene results in decreased expression of GAS5 mRNA
CTD
PMID:25075043
NCBI chr13:75,836,963...75,840,284
G
Gbp6
guanylate binding protein family member 6
increases expression
ISO
alpha phellandrene results in increased expression of GBP6 mRNA
CTD
PMID:25075043
NCBI chr14:5,034,999...5,062,023
Ensembl chr14:4,730,453...4,839,062 Ensembl chr14:4,730,453...4,839,062
G
Gnas
GNAS complex locus
increases expression
ISO
alpha phellandrene results in increased expression of GNAS mRNA
CTD
PMID:25075043
NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
G
Gnl3
G protein nucleolar 3
decreases expression
ISO
alpha phellandrene results in decreased expression of GNL3 mRNA
CTD
PMID:25075043
NCBI chr16:6,213,844...6,220,029
Ensembl chr16:6,207,402...6,213,392
G
Gpr84
G protein-coupled receptor 84
decreases expression
ISO
alpha phellandrene results in decreased expression of GPR84 mRNA
CTD
PMID:25075043
NCBI chr 7:136,322,374...136,324,648
Ensembl chr 7:134,443,936...134,446,178
G
Greb1l
GREB1 like retinoic acid receptor coactivator
increases expression
ISO
alpha phellandrene results in increased expression of GREB1L mRNA
CTD
PMID:25075043
NCBI chr18:1,665,468...1,902,291
Ensembl chr18:1,392,725...1,628,067
G
Grina
glutamate ionotropic receptor NMDA type subunit associated protein 1
increases expression
ISO
alpha phellandrene results in increased expression of GRINA mRNA
CTD
PMID:25075043
NCBI chr 7:109,842,870...109,846,048
Ensembl chr 7:107,962,207...107,965,366
G
Gtdc1
glycosyltransferase-like domain containing 1
increases expression
ISO
alpha phellandrene results in increased expression of GTDC1 mRNA
CTD
PMID:25075043
NCBI chr 3:49,176,110...49,571,594
Ensembl chr 3:28,766,645...29,162,271
G
Gys1
glycogen synthase 1
increases expression
ISO
alpha phellandrene results in increased expression of GYS1 mRNA
CTD
PMID:25075043
NCBI chr 1:105,051,916...105,071,763
Ensembl chr 1:95,915,443...95,935,292
G
Gzmf
granzyme F
decreases expression
ISO
alpha phellandrene results in decreased expression of GZME mRNA
CTD
PMID:25075043
NCBI chr15:33,975,543...33,997,505
Ensembl chr15:30,007,267...30,018,649
G
H1f0
H1.0 linker histone
increases expression
ISO
alpha phellandrene results in increased expression of H1F0 mRNA
CTD
PMID:25075043
NCBI chr 7:112,473,280...112,475,140
Ensembl chr 7:110,592,208...110,594,694
G
H1f2
H1.2 linker histone, cluster member
increases expression
ISO
alpha phellandrene results in increased expression of H1F2 mRNA
CTD
PMID:25075043
NCBI chr17:41,818,962...41,820,453
Ensembl chr17:41,388,477...41,392,635
G
H2bc18
H2B clustered histone 18
increases expression
ISO
alpha phellandrene results in increased expression of H2BC18 mRNA
CTD
PMID:25075043
NCBI chr 2:186,527,197...186,531,634
Ensembl chr 2:183,838,334...183,841,529
G
Hcar2
hydroxycarboxylic acid receptor 2
increases expression
ISO
alpha phellandrene results in increased expression of HCAR2 mRNA
CTD
PMID:25075043
NCBI chr12:38,387,163...38,389,149
Ensembl chr12:32,726,184...32,728,504
G
Heatr1
HEAT repeat containing 1
decreases expression
ISO
alpha phellandrene results in decreased expression of HEATR1 mRNA
CTD
PMID:25075043
NCBI chr17:62,745,008...62,785,609
Ensembl chr17:58,051,700...58,093,948
G
Helz2
helicase with zinc finger 2
increases expression
ISO
alpha phellandrene results in increased expression of HELZ2 mRNA
CTD
PMID:25075043
NCBI chr 3:188,716,370...188,730,776
Ensembl chr 3:168,338,813...168,353,159
G
Hgh1
HGH1 homolog
decreases expression
ISO
alpha phellandrene results in decreased expression of BRP16 mRNA
CTD
PMID:25075043
NCBI chr 7:109,972,079...109,975,398
Ensembl chr 7:108,091,951...108,094,737
G
Hilpda
hypoxia inducible lipid droplet-associated
increases expression
ISO
alpha phellandrene results in increased expression of HILPDA mRNA
CTD
PMID:25075043
NCBI chr 4:58,836,463...58,839,423
Ensembl chr 4:57,871,110...57,874,557
G
Hivep3
HIVEP zinc finger 3
increases expression
ISO
alpha phellandrene results in increased expression of HIVEP3 mRNA
CTD
PMID:25075043
NCBI chr 5:138,610,592...139,013,058
Ensembl chr 5:133,658,052...133,727,795
G
Hspa2
heat shock protein family A (Hsp70) member 2
increases expression
ISO
alpha phellandrene results in increased expression of HSPA2 mRNA
CTD
PMID:25075043
NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:95,128,350...95,131,287
G
Hspa5
heat shock protein family A (Hsp70) member 5
decreases expression
ISO
alpha phellandrene results in decreased expression of HSPA5 mRNA
CTD
PMID:25075043
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
G
Hspa8
heat shock protein family A (Hsp70) member 8
decreases expression
ISO
alpha phellandrene results in decreased expression of HSPA8 mRNA
CTD
PMID:25075043
NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259
G
Id2
inhibitor of DNA binding 2
increases expression
ISO
alpha phellandrene results in increased expression of ID2 mRNA
CTD
PMID:25075043
NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:41,728,946...41,744,400
G
Idi1
isopentenyl-diphosphate delta isomerase 1
decreases expression
ISO
alpha phellandrene results in decreased expression of IDI1 mRNA
CTD
PMID:25075043
NCBI chr17:66,539,761...66,547,524
Ensembl chr17:61,629,594...61,637,357
G
Ifih1
interferon induced with helicase C domain 1
increases expression
ISO
alpha phellandrene results in increased expression of IFIH1 mRNA
CTD
PMID:25075043
NCBI chr 3:67,635,924...67,683,968
Ensembl chr 3:47,227,364...47,275,456
G
Ifnl3
interferon, lambda 3
increases expression
ISO
alpha phellandrene results in increased expression of IFNL3 mRNA
CTD
PMID:25075043
NCBI chr 1:92,941,988...92,943,628
Ensembl chr 1:83,814,564...83,816,096
G
Il2ra
interleukin 2 receptor subunit alpha
decreases expression
ISO
alpha phellandrene results in decreased expression of IL2RA mRNA
CTD
PMID:25075043
NCBI chr17:71,759,802...71,808,475
Ensembl chr17:66,849,974...66,898,697
G
Il36g
interleukin 36, gamma
decreases expression
ISO
alpha phellandrene results in decreased expression of IL36G mRNA
CTD
PMID:25075043
NCBI chr 3:27,346,675...27,352,839
Ensembl chr 3:6,948,297...6,954,480
G
Irf5
interferon regulatory factor 5
increases expression
ISO
alpha phellandrene results in increased expression of IRF5 mRNA
CTD
PMID:25075043
NCBI chr 4:59,092,914...59,104,596
Ensembl chr 4:58,127,640...58,139,267
G
Irf7
interferon regulatory factor 7
increases expression
ISO
alpha phellandrene results in increased expression of IRF7 mRNA
CTD
PMID:25075043
NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:196,367,361...196,370,832
G
Irgm
immunity-related GTPase M
increases expression
ISO
alpha phellandrene results in increased expression of IRGM2 mRNA
CTD
PMID:25075043
NCBI chr10:33,734,640...33,742,720
Ensembl chr10:33,233,455...33,241,578
G
Itgal
integrin subunit alpha L
increases expression
ISO
alpha phellandrene results in increased expression of ITGAL mRNA
CTD
PMID:25075043
NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:181,918,183...181,955,732
G
Jagn1
jagunal homolog 1
decreases expression
ISO
alpha phellandrene results in decreased expression of JAGN1 mRNA
CTD
PMID:25075043
NCBI chr 4:148,147,213...148,151,915
Ensembl chr 4:146,591,510...146,596,288
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
alpha phellandrene results in increased expression of JUN mRNA
CTD
PMID:25075043
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
G
Kank2
KN motif and ankyrin repeat domains 2
decreases expression
ISO
alpha phellandrene results in decreased expression of KANK2 mRNA
CTD
PMID:25075043
NCBI chr 8:28,587,770...28,617,212
Ensembl chr 8:20,311,676...20,340,900
G
Kdm7a
lysine demethylase 7A
increases expression
ISO
alpha phellandrene results in increased expression of KDM7A mRNA
CTD
PMID:25075043
NCBI chr 4:68,866,263...68,992,979
Ensembl chr 4:67,904,307...67,966,998
G
Klhl24
kelch-like family member 24
increases expression
ISO
alpha phellandrene results in increased expression of KLHL24 mRNA
CTD
PMID:25075043
NCBI chr11:94,348,024...94,382,085
Ensembl chr11:80,846,755...80,877,636
G
Lima1
LIM domain and actin binding 1
increases expression
ISO
alpha phellandrene results in increased expression of LIMA1 mRNA
CTD
PMID:25075043
NCBI chr 7:132,780,556...132,880,343
Ensembl chr 7:130,901,717...131,001,473
G
Llgl2
LLGL scribble cell polarity complex component 2
decreases expression
ISO
alpha phellandrene results in decreased expression of LLGL2 mRNA
CTD
PMID:25075043
NCBI chr10:101,549,911...101,585,466
Ensembl chr10:101,051,408...101,086,525
G
LOC120098677
small nucleolar RNA MBII-202
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORD68 mRNA
CTD
PMID:25075043
NCBI chr19:68,063,150...68,063,232
Ensembl chr19:51,154,626...51,154,708
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Lpp
LIM domain containing preferred translocation partner in lipoma
increases expression
ISO
alpha phellandrene results in increased expression of LPP mRNA
CTD
PMID:25075043
NCBI chr11:89,292,060...89,933,973
Ensembl chr11:75,797,078...76,422,597
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Ltn1
listerin E3 ubiquitin protein ligase 1
decreases expression
ISO
alpha phellandrene results in decreased expression of LTN1 mRNA
CTD
PMID:25075043
NCBI chr11:40,090,169...40,147,159
Ensembl chr11:26,603,903...26,660,886
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Ly6h
lymphocyte antigen 6 family member H
decreases expression
ISO
alpha phellandrene results in decreased expression of LY6C1 mRNA; alpha phellandrene results in decreased expression of LY6C2 mRNA
CTD
PMID:25075043
NCBI chr 7:109,139,527...109,142,108
Ensembl chr 7:107,258,779...107,261,454
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Map2k6
mitogen-activated protein kinase kinase 6
increases expression
ISO
alpha phellandrene results in increased expression of MAP2K6 mRNA
CTD
PMID:25075043
NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,373,204...95,488,293
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Mat2a
methionine adenosyltransferase 2A
decreases expression
ISO
alpha phellandrene results in decreased expression of MAT2A mRNA
CTD
PMID:25075043
NCBI chr 4:106,048,043...106,053,612
Ensembl chr 4:104,488,466...104,495,493
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Mcemp1
mast cell-expressed membrane protein 1
increases expression
ISO
alpha phellandrene results in increased expression of MCEMP1 mRNA
CTD
PMID:25075043
NCBI chr12:6,519,709...6,523,880
Ensembl chr12:1,718,730...1,725,986
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Mdc1
mediator of DNA damage checkpoint 1
increases expression
ISO
alpha phellandrene results in increased expression of MDC1 protein
CTD
PMID:24861204
NCBI chr20:2,898,496...2,914,960
Ensembl chr20:2,895,505...2,910,240
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Mdn1
midasin AAA ATPase 1
decreases expression
ISO
alpha phellandrene results in decreased expression of MDN1 mRNA
CTD
PMID:25075043
NCBI chr 5:51,851,785...51,982,688
Ensembl chr 5:47,055,447...47,186,332
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Med29
mediator complex subunit 29
decreases expression
ISO
alpha phellandrene results in decreased expression of MED29 mRNA
CTD
PMID:25075043
NCBI chr 1:92,805,505...92,810,908
Ensembl chr 1:83,677,961...83,683,365
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Med31
mediator complex subunit 31
increases expression
ISO
alpha phellandrene results in increased expression of MED31 mRNA
CTD
PMID:25075043
NCBI chr10:57,335,507...57,338,889
Ensembl chr10:56,836,944...56,840,326
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Mgarp
mitochondria-localized glutamic acid-rich protein
increases expression
ISO
alpha phellandrene results in increased expression of MGARP mRNA
CTD
PMID:25075043
NCBI chr 2:137,582,152...137,590,294
Ensembl chr 2:135,431,283...135,439,612
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Mgat2
alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
decreases expression
ISO
alpha phellandrene results in decreased expression of MGAT2 mRNA
CTD
PMID:25075043
NCBI chr 6:93,392,416...93,394,905
Ensembl chr 6:87,656,349...87,658,177
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Mgmt
O-6-methylguanine-DNA methyltransferase
decreases expression
ISO
alpha phellandrene results in decreased expression of MGMT protein
CTD
PMID:24861204
NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756
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Mindy2
MINDY lysine 48 deubiquitinase 2
increases expression
ISO
alpha phellandrene results in increased expression of MINDY2 mRNA
CTD
PMID:25075043
NCBI chr 8:80,149,127...80,210,011
Ensembl chr 8:71,256,447...71,328,453
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Mir375
microRNA 375
increases expression
ISO
alpha phellandrene results in increased expression of MIR375 mRNA
CTD
PMID:25075043
NCBI chr 9:83,906,582...83,906,656
Ensembl chr 9:76,457,911...76,457,985
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Mr1
major histocompatibility complex, class I-related
increases expression
ISO
alpha phellandrene results in increased expression of MR1 mRNA
CTD
PMID:25075043
NCBI chr13:69,850,420...69,868,302
Ensembl chr13:67,299,585...67,317,970
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Mrpl20
mitochondrial ribosomal protein L20
decreases expression
ISO
alpha phellandrene results in decreased expression of MRPL20 mRNA
CTD
PMID:25075043
NCBI chr 5:171,690,664...171,695,728
Ensembl chr 5:166,408,962...166,413,492
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Mrpl45
mitochondrial ribosomal protein L45
increases expression
ISO
alpha phellandrene results in increased expression of MRPL45 mRNA
CTD
PMID:25075043
NCBI chr10:82,805,039...82,816,862
Ensembl chr10:82,308,427...82,320,474
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Mrto4
MRT4 homolog, ribosome maturation factor
decreases expression
ISO
alpha phellandrene results in decreased expression of MRTO4 mRNA
CTD
PMID:25075043
NCBI chr 5:156,884,985...156,891,738
Ensembl chr 5:151,601,780...151,608,287
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Ms4a3
membrane spanning 4-domains A3
decreases expression
ISO
alpha phellandrene results in decreased expression of MS4A3 mRNA
CTD
PMID:25075043
NCBI chr 1:217,887,105...217,904,921
Ensembl chr 1:208,462,301...208,480,101
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Mtor
mechanistic target of rapamycin kinase
decreases expression
ISO
alpha phellandrene results in decreased expression of MTOR protein
CTD
PMID:25649747
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
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Mtx3
metaxin 3
decreases expression
ISO
alpha phellandrene results in decreased expression of MTX3 mRNA
CTD
PMID:25075043
NCBI chr 2:25,800,530...25,814,755
Ensembl chr 2:24,066,365...24,079,670
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Muc13
mucin 13, cell surface associated
decreases expression
ISO
alpha phellandrene results in decreased expression of MUC13 mRNA
CTD
PMID:25075043
NCBI chr11:80,462,350...80,489,773
Ensembl chr11:66,960,595...66,984,727
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Mx2
MX dynamin like GTPase 2
increases expression
ISO
alpha phellandrene results in increased expression of MX2 mRNA
CTD
PMID:25075043
NCBI chr11:50,375,101...50,399,373
Ensembl chr11:36,906,111...36,930,342
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Mxd1
max dimerization protein 1
increases expression
ISO
alpha phellandrene results in increased expression of MXD1 mRNA
CTD
PMID:25075043
NCBI chr 4:120,654,731...120,678,972
Ensembl chr 4:119,097,353...119,117,751
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Myadm
myeloid-associated differentiation marker
increases expression
ISO
alpha phellandrene results in increased expression of MYADM mRNA
CTD
PMID:25075043
NCBI chr 1:74,779,616...74,796,752
Ensembl chr 1:65,864,173...65,874,035
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Mybbp1a
MYB binding protein 1a
decreases expression
ISO
alpha phellandrene results in decreased expression of MYBBP1A mRNA
CTD
PMID:25075043
NCBI chr10:57,555,458...57,565,819
Ensembl chr10:57,056,874...57,067,255
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Myo9a
myosin IXA
increases expression
ISO
alpha phellandrene results in increased expression of MYO9A mRNA
CTD
PMID:25075043
NCBI chr 8:69,044,853...69,248,094
Ensembl chr 8:60,149,234...60,350,514
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Nampt
nicotinamide phosphoribosyltransferase
increases expression
ISO
alpha phellandrene results in increased expression of NAMPT mRNA
CTD
PMID:25075043
NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:49,424,332...49,462,100
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Nat10
N-acetyltransferase 10
decreases expression
ISO
alpha phellandrene results in decreased expression of NAT10 mRNA
CTD
PMID:25075043
NCBI chr 3:110,566,582...110,604,829
Ensembl chr 3:90,111,645...90,149,927
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Ndrg2
NDRG family member 2
increases expression
ISO
alpha phellandrene results in increased expression of NDRG2 mRNA
CTD
PMID:25075043
NCBI chr15:27,074,481...27,087,376
Ensembl chr15:24,600,982...24,609,626
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Nfil3
nuclear factor, interleukin 3 regulated
increases expression
ISO
alpha phellandrene results in increased expression of NFIL3 mRNA
CTD
PMID:25075043
NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,280,484...12,295,858
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Nfkbia
NFKB inhibitor alpha
increases expression
ISO
alpha phellandrene results in increased expression of NFKBIA mRNA
CTD
PMID:25075043
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
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Nhp2
NHP2 ribonucleoprotein
decreases expression
ISO
alpha phellandrene results in decreased expression of NHP2 mRNA
CTD
PMID:25075043
NCBI chr10:36,378,020...36,381,362
Ensembl chr10:35,877,054...35,882,545
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Nol10
nucleolar protein 10
decreases expression
ISO
alpha phellandrene results in decreased expression of NOL10 mRNA
CTD
PMID:25075043
NCBI chr 6:45,861,773...45,954,067
Ensembl chr 6:40,144,235...40,225,353
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Nol8
nucleolar protein 8
decreases expression
ISO
alpha phellandrene results in decreased expression of NOL8 mRNA
CTD
PMID:25075043
NCBI chr17:15,196,881...15,220,265
Ensembl chr17:14,990,417...15,013,848
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Nolc1
nucleolar and coiled-body phosphoprotein 1
decreases expression
ISO
alpha phellandrene results in decreased expression of NOLC1 mRNA
CTD
PMID:25075043
NCBI chr 1:254,870,195...254,881,070
Ensembl chr 1:244,921,377...244,932,088
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Nop2
NOP2 nucleolar protein
decreases expression
ISO
alpha phellandrene results in decreased expression of NOP2 mRNA
CTD
PMID:25075043
NCBI chr 4:159,618,894...159,630,697
Ensembl chr 4:157,932,716...157,944,459
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Nop56
NOP56 ribonucleoprotein
decreases expression
ISO
alpha phellandrene results in decreased expression of NOP56 mRNA
CTD
PMID:25075043
NCBI chr 3:137,926,187...137,934,971
Ensembl chr 3:117,477,053...117,481,841
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Nos2
nitric oxide synthase 2
increases expression
ISO
alpha phellandrene results in increased expression of NOS2 mRNA
CTD
PMID:25075043
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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Nxt2
nuclear transport factor 2-like export factor 2
increases expression
ISO
alpha phellandrene results in increased expression of NXT2 mRNA
CTD
PMID:25075043
NCBI chr X:110,652,434...110,659,738
Ensembl chr X:105,855,608...105,862,899
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Oas1a
2'-5' oligoadenylate synthetase 1A
increases expression
ISO
alpha phellandrene results in increased expression of OAS1A mRNA; alpha phellandrene results in increased expression of OAS1B mRNA
CTD
PMID:25075043
NCBI chr12:41,330,423...41,341,130
Ensembl chr12:35,669,801...35,680,517
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Oas3
2'-5'-oligoadenylate synthetase 3
increases expression
ISO
alpha phellandrene results in increased expression of OAS3 mRNA
CTD
PMID:25075043
NCBI chr12:41,439,645...41,463,392
Ensembl chr12:35,779,022...35,802,781
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Osbpl9
oxysterol binding protein-like 9
increases expression
ISO
alpha phellandrene results in increased expression of OSBPL9 mRNA
CTD
PMID:25075043
NCBI chr 5:129,047,776...129,190,838
Ensembl chr 5:123,819,104...123,962,196
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Pabir2
PABIR family member 2
increases expression
ISO
alpha phellandrene results in increased expression of PABIR2 mRNA
CTD
PMID:25075043
NCBI chr X:137,908,653...137,935,153
Ensembl chr X:132,989,124...133,015,580
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Parp14
poly (ADP-ribose) polymerase family, member 14
increases expression
ISO
alpha phellandrene results in increased expression of PARP14 mRNA
CTD
PMID:25075043
NCBI chr11:78,408,134...78,440,201
Ensembl chr11:64,902,785...64,934,916
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Pcyox1l
prenylcysteine oxidase 1 like
decreases expression
ISO
alpha phellandrene results in decreased expression of PCYOX1L mRNA
CTD
PMID:25075043
NCBI chr18:57,420,971...57,431,632
Ensembl chr18:55,150,650...55,161,327
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Pde3b
phosphodiesterase 3B
increases expression
ISO
alpha phellandrene results in increased expression of PDE3B mRNA
CTD
PMID:25075043
NCBI chr 1:178,041,207...178,204,503
Ensembl chr 1:168,607,022...168,769,334
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Phospho1
phosphoethanolamine/phosphocholine phosphatase 1
increases expression
ISO
alpha phellandrene results in increased expression of PHOSPHO1 mRNA
CTD
PMID:25075043
NCBI chr10:81,258,810...81,266,345
Ensembl chr10:80,760,792...80,770,342
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Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
increases expression
ISO
alpha phellandrene results in increased expression of PIK3CB mRNA
CTD
PMID:25075043
NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663
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Pld4
phospholipase D family, member 4
increases expression
ISO
alpha phellandrene results in increased expression of PLD4 mRNA
CTD
PMID:25075043
NCBI chr 6:137,639,948...137,647,462
Ensembl chr 6:131,818,860...131,826,376
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Plxdc1
plexin domain containing 1
increases expression
ISO
alpha phellandrene results in increased expression of PLXDC1 mRNA
CTD
PMID:25075043
NCBI chr10:83,418,837...83,478,451
Ensembl chr10:82,922,508...82,982,130
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Pnrc2
proline-rich nuclear receptor coactivator 2
increases expression
ISO
alpha phellandrene results in increased expression of PNRC2 mRNA
CTD
PMID:25075043
NCBI chr 5:153,387,522...153,390,506
Ensembl chr 5:148,095,699...148,107,242 Ensembl chr 5:148,095,699...148,107,242
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Polr1b
RNA polymerase I subunit B
decreases expression
ISO
alpha phellandrene results in decreased expression of POLR1B mRNA
CTD
PMID:25075043
NCBI chr 3:136,787,130...136,811,608
Ensembl chr 3:116,333,889...116,358,379
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Pop1
POP1 homolog, ribonuclease P/MRP subunit
decreases expression
ISO
alpha phellandrene results in decreased expression of POP1 mRNA
CTD
PMID:25075043
NCBI chr 7:67,590,502...67,618,187
Ensembl chr 7:65,705,368...65,733,141
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Ppan
peter pan homolog
decreases expression
ISO
alpha phellandrene results in decreased expression of PPAN mRNA
CTD
PMID:25075043
NCBI chr 8:27,700,147...27,704,127
Ensembl chr 8:19,423,961...19,427,938
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Ppat
phosphoribosyl pyrophosphate amidotransferase
decreases expression
ISO
alpha phellandrene results in decreased expression of PPAT mRNA
CTD
PMID:25075043
NCBI chr14:31,570,010...31,604,410
Ensembl chr14:31,216,165...31,250,144
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Ppm1k
protein phosphatase, Mg2+/Mn2+ dependent, 1K
increases expression
ISO
alpha phellandrene results in increased expression of PPM1K mRNA
CTD
PMID:25075043
NCBI chr 4:88,942,226...88,969,139
Ensembl chr 4:87,612,204...87,636,152
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Ppp2r5c
protein phosphatase 2, regulatory subunit B', gamma
increases expression
ISO
alpha phellandrene results in increased expression of PPP2R5C mRNA
CTD
PMID:25075043
NCBI chr 6:135,282,947...135,419,591
Ensembl chr 6:129,461,648...129,598,346
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Pprc1
PPARG related coactivator 1
decreases expression
ISO
alpha phellandrene results in decreased expression of PPRC1 mRNA
CTD
PMID:25075043
NCBI chr 1:254,851,136...254,867,570
Ensembl chr 1:244,902,179...244,918,587
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Prkdc
protein kinase, DNA-activated, catalytic subunit
decreases expression
ISO
alpha phellandrene results in decreased expression of PRKDC protein
CTD
PMID:24861204
NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952
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Prss1
serine protease 1
decreases expression
ISO
alpha phellandrene results in decreased expression of TRY10 mRNA
CTD
PMID:25075043
NCBI chr 4:71,331,249...71,334,452
Ensembl chr 4:70,364,586...70,367,792
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Ptbp3
polypyrimidine tract binding protein 3
increases expression
ISO
alpha phellandrene results in increased expression of PTBP3 mRNA
CTD
PMID:25075043
NCBI chr 5:79,108,376...79,194,533
Ensembl chr 5:74,315,101...74,399,791
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Ptpmt1
protein tyrosine phosphatase, mitochondrial 1
decreases expression
ISO
alpha phellandrene results in decreased expression of PTPMT1 mRNA
CTD
PMID:25075043
NCBI chr 3:97,345,752...97,355,396
Ensembl chr 3:76,889,922...76,899,427
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Ptpn7
protein tyrosine phosphatase, non-receptor type 7
decreases expression
ISO
alpha phellandrene results in decreased expression of PTPN7 mRNA
CTD
PMID:25075043
NCBI chr13:49,122,679...49,136,096
Ensembl chr13:46,571,712...46,583,308
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Pus7
pseudouridine synthase 7
decreases expression
ISO
alpha phellandrene results in decreased expression of PUS7 mRNA
CTD
PMID:25075043
NCBI chr 4:12,252,553...12,293,547
Ensembl chr 4:11,360,188...11,401,172
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Pus7l
pseudouridine synthase 7 like
decreases expression
ISO
alpha phellandrene results in decreased expression of PUS7L mRNA
CTD
PMID:25075043
NCBI chr 7:127,538,785...127,561,936
Ensembl chr 7:125,659,507...125,682,333
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Rad51c
RAD51 paralog C
increases expression
ISO
alpha phellandrene results in increased expression of RAD51C mRNA
CTD
PMID:25075043
NCBI chr10:72,702,299...72,728,980
Ensembl chr10:72,205,032...72,231,248
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Rap2b
RAP2B, member of RAS oncogene family
increases expression
ISO
alpha phellandrene results in increased expression of RAP2B mRNA
CTD
PMID:25075043
NCBI chr 2:147,749,387...147,749,938
Ensembl chr 2:145,599,116...145,603,069
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Rbm12b
RNA binding motif protein 12B
decreases expression
ISO
alpha phellandrene results in decreased expression of RBM12B2 mRNA
CTD
PMID:25075043
NCBI chr 5:30,394,756...30,507,428
Ensembl chr 5:25,590,493...25,611,245
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Rbpj
recombination signal binding protein for immunoglobulin kappa J region
increases expression
ISO
alpha phellandrene results in increased expression of RBPJ mRNA
CTD
PMID:25075043
NCBI chr14:61,551,366...61,736,220
Ensembl chr14:57,338,507...57,523,353
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Rcl1
RNA terminal phosphate cyclase-like 1
decreases expression
ISO
alpha phellandrene results in decreased expression of RCL1 mRNA
CTD
PMID:25075043
NCBI chr 1:236,238,078...236,282,597
Ensembl chr 1:226,824,534...226,902,315
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RGD1359108
similar to RIKEN cDNA 3110043O21
increases expression
ISO
alpha phellandrene results in increased expression of C9ORF72 mRNA
CTD
PMID:25075043
NCBI chr 5:54,562,570...54,587,649
Ensembl chr 5:49,766,325...49,791,408
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Rhobtb2
Rho-related BTB domain containing 2
increases expression
ISO
alpha phellandrene results in increased expression of RHOBTB2 mRNA
CTD
PMID:25075043
NCBI chr15:51,278,024...51,298,209
Ensembl chr15:44,870,376...44,888,651
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Rig1
RNA sensor RIG-1
increases expression
ISO
alpha phellandrene results in increased expression of RIGI mRNA
CTD
PMID:25075043
NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:55,321,235...55,370,819
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Rnf141
ring finger protein 141
increases expression
ISO
alpha phellandrene results in increased expression of RNF141 mRNA
CTD
PMID:25075043
NCBI chr 1:174,365,789...174,391,848
Ensembl chr 1:164,931,077...164,957,118
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Rnf19b
ring finger protein 19B
increases expression
ISO
alpha phellandrene results in increased expression of RNF19B mRNA
CTD
PMID:25075043
NCBI chr 5:146,690,453...146,715,729
Ensembl chr 5:141,406,118...141,431,380
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Rp2
RP2 activator of ARL3 GTPase
increases expression
ISO
alpha phellandrene results in increased expression of RP2 mRNA
CTD
PMID:25075043
NCBI chr X:4,426,071...4,470,200
Ensembl chr X:1,873,306...1,916,688
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Rpp14
ribonuclease P/MRP subunit p14
decreases expression
ISO
alpha phellandrene results in decreased expression of RPP14 mRNA
CTD
PMID:25075043
NCBI chr15:19,268,025...19,278,216
Ensembl chr15:16,836,859...16,852,101 Ensembl chr15:16,836,859...16,852,101
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Rpp38
ribonuclease P/MRP subunit p38
decreases expression
ISO
alpha phellandrene results in decreased expression of RPP38 mRNA
CTD
PMID:25075043
NCBI chr17:79,823,237...79,826,908
Ensembl chr17:74,908,932...74,927,431
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Rps12
ribosomal protein S12
decreases expression
ISO
alpha phellandrene results in decreased expression of RPS12 mRNA
CTD
PMID:25075043
NCBI chr 1:23,499,943...23,502,234
Ensembl chr 1:21,680,852...21,683,014
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Rras
RAS related
increases expression
ISO
alpha phellandrene results in increased expression of RRAS mRNA
CTD
PMID:25075043
NCBI chr 1:104,637,061...104,640,841
Ensembl chr 1:95,500,566...95,504,357
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Rrp12
ribosomal RNA processing 12
decreases expression
ISO
alpha phellandrene results in decreased expression of RRP12 mRNA
CTD
PMID:25075043
NCBI chr 1:250,621,707...250,655,318
Ensembl chr 1:240,672,382...240,706,018
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Rrp15
ribosomal RNA processing 15 homolog
decreases expression
ISO
alpha phellandrene results in decreased expression of RRP15 mRNA
CTD
PMID:25075043
NCBI chr13:100,807,729...100,830,812
Ensembl chr13:98,276,134...98,299,370
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Rsad2
radical S-adenosyl methionine domain containing 2
increases expression
ISO
alpha phellandrene results in increased expression of RSAD2 mRNA
CTD
PMID:25075043
NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:43,047,658...43,059,699
G
Rtl1
retrotransposon-like 1
decreases expression
ISO
alpha phellandrene results in decreased expression of RTL1 mRNA
CTD
PMID:25075043
NCBI chr 6:134,325,231...134,335,780
Ensembl chr 6:128,543,939...128,549,182
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Rtl8a
retrotransposon Gag like 8A
increases expression
ISO
alpha phellandrene results in increased expression of RTL8A mRNA
CTD
PMID:25075043
NCBI chr X:138,436,824...138,438,037
Ensembl chr X:133,414,030...133,415,240
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Rtp4
receptor (chemosensory) transporter protein 4
increases expression
ISO
alpha phellandrene results in increased expression of RTP4 mRNA
CTD
PMID:25075043
NCBI chr11:90,741,992...90,840,061
Ensembl chr11:77,238,216...77,335,437
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Rubcnl
rubicon like autophagy enhancer
increases expression
ISO
alpha phellandrene results in increased expression of RUBCNL mRNA
CTD
PMID:25075043
NCBI chr15:56,741,897...56,807,086
Ensembl chr15:50,332,418...50,400,849
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Samhd1
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
increases expression
ISO
alpha phellandrene results in increased expression of SAMHD1 mRNA
CTD
PMID:25075043
NCBI chr 3:166,179,742...166,214,448
Ensembl chr 3:145,761,558...145,794,386
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Sat1
spermidine/spermine N1-acetyl transferase 1
increases expression
ISO
alpha phellandrene results in increased expression of SAT1 mRNA
CTD
PMID:25075043
NCBI chr X:44,008,089...44,011,376
Ensembl chr X:40,157,046...40,196,813
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Sdad1
SDA1 domain containing 1
decreases expression
ISO
alpha phellandrene results in decreased expression of SDAD1 mRNA
CTD
PMID:25075043
NCBI chr14:16,025,726...16,052,565
Ensembl chr14:15,741,434...15,771,066
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Sec14l1
SEC14-like lipid binding 1
increases expression
ISO
alpha phellandrene results in increased expression of SEC14L1 mRNA
CTD
PMID:25075043
NCBI chr10:102,818,693...102,865,841
Ensembl chr10:102,319,920...102,367,068
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Selenbp1
selenium binding protein 1
increases expression
ISO
alpha phellandrene results in increased expression of SELENBP1 mRNA; alpha phellandrene results in increased expression of SELENBP2 mRNA
CTD
PMID:25075043
NCBI chr 2:185,183,022...185,193,612
Ensembl chr 2:182,493,978...182,504,594
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Sema3c
semaphorin 3C
decreases expression
ISO
alpha phellandrene results in decreased expression of SEMA3C mRNA
CTD
PMID:25075043
NCBI chr 4:18,538,452...18,702,453
Ensembl chr 4:17,583,212...17,746,534
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Senp2
SUMO specific peptidase 2
decreases expression
ISO
alpha phellandrene results in decreased expression of SENP2 mRNA
CTD
PMID:25075043
NCBI chr11:92,487,259...92,522,795
Ensembl chr11:78,981,432...79,018,238
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Septin8
septin 8
increases expression
ISO
alpha phellandrene results in increased expression of SEPT8 mRNA
CTD
PMID:25075043
NCBI chr10:38,185,454...38,214,502
Ensembl chr10:37,684,639...37,713,174
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Sertad3
SERTA domain containing 3
increases expression
ISO
alpha phellandrene results in increased expression of SERTAD3 mRNA
CTD
PMID:25075043
NCBI chr 1:91,891,141...91,894,861
Ensembl chr 1:82,763,149...82,769,001
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Set
Set nuclear proto-oncogene
decreases expression
ISO
alpha phellandrene results in decreased expression of SET mRNA
CTD
PMID:25075043
NCBI chr 3:33,732,319...33,743,433
Ensembl chr 3:13,335,041...13,363,567
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Sfn
stratifin
increases expression
ISO
alpha phellandrene results in increased expression of SFN protein
CTD
PMID:24861204
NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:145,826,201...145,831,314
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Sgf29
SAGA complex associated factor 29
decreases expression
ISO
alpha phellandrene results in decreased expression of SGF29 mRNA
CTD
PMID:25075043
NCBI chr 1:190,668,803...190,702,500
Ensembl chr 1:181,238,468...181,274,781
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Sgo2
shugoshin 2
increases expression
ISO
alpha phellandrene results in increased expression of SGO2A mRNA
CTD
PMID:25075043
NCBI chr 9:67,032,083...67,067,439
Ensembl chr 9:59,548,683...59,573,229
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Sigmar1
sigma non-opioid intracellular receptor 1
decreases expression
ISO
alpha phellandrene results in decreased expression of SIGMAR1 mRNA
CTD
PMID:25075043
NCBI chr 5:61,700,021...61,702,799
Ensembl chr 5:56,904,159...56,907,017
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Slc1a5
solute carrier family 1 member 5
decreases expression
ISO
alpha phellandrene results in decreased expression of SLC1A5 mRNA
CTD
PMID:25075043
NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:77,456,694...77,470,952
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Slc35b1
solute carrier family 35, member B1
decreases expression
ISO
alpha phellandrene results in decreased expression of SLC35B1 mRNA
CTD
PMID:25075043
NCBI chr10:80,824,972...80,832,048
Ensembl chr10:80,327,945...80,335,274
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Slc35d1
solute carrier family 35 member D1
decreases expression
ISO
alpha phellandrene results in decreased expression of SLC35D1 mRNA
CTD
PMID:25075043
NCBI chr 5:123,157,739...123,210,350
Ensembl chr 5:117,934,352...117,981,311
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Slc44a1
solute carrier family 44 member 1
increases expression
ISO
alpha phellandrene results in increased expression of SLC44A1 mRNA
CTD
PMID:25075043
NCBI chr 5:72,857,323...73,037,279
Ensembl chr 5:68,063,618...68,241,909
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Slc44a3
solute carrier family 44, member 3
increases expression
ISO
alpha phellandrene results in increased expression of SLC44A3 mRNA
CTD
PMID:25075043
NCBI chr 2:212,234,425...212,312,886
Ensembl chr 2:209,552,144...209,629,044
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Slc7a1
solute carrier family 7 member 1
decreases expression
ISO
alpha phellandrene results in decreased expression of SLC7A1 mRNA
CTD
PMID:25075043
NCBI chr12:11,664,488...11,740,030
Ensembl chr12:6,628,007...6,703,849
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Slc7a11
solute carrier family 7 member 11
decreases expression
ISO
alpha phellandrene results in decreased expression of SLC7A11 mRNA
CTD
PMID:25075043
NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536
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Slc7a6
solute carrier family 7 member 6
decreases expression
ISO
alpha phellandrene results in decreased expression of SLC7A6 mRNA
CTD
PMID:25075043
NCBI chr19:50,982,459...51,010,140
Ensembl chr19:34,074,286...34,100,268
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Slfn5
schlafen family member 5
increases expression
ISO
alpha phellandrene results in increased expression of SLFN4 mRNA; alpha phellandrene results in increased expression of SLFN5 mRNA
CTD
PMID:25075043
NCBI chr10:68,378,440...68,392,515
Ensembl chr10:67,880,009...67,893,109
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Smim14
small integral membrane protein 14
increases expression
ISO
alpha phellandrene results in increased expression of SMIM14 mRNA
CTD
PMID:25075043
NCBI chr14:43,136,754...43,180,622
Ensembl chr14:42,783,332...42,829,760
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Smox
spermine oxidase
increases expression
ISO
alpha phellandrene results in increased expression of SMOX mRNA
CTD
PMID:25075043
NCBI chr 3:139,184,793...139,220,174
Ensembl chr 3:118,731,900...118,765,710 Ensembl chr X:118,731,900...118,765,710
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Snora20
small nucleolar RNA, H/ACA box 20
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORA20 mRNA
CTD
PMID:25075043
NCBI chr 8:80,023,645...80,023,774
Ensembl chr 8:71,142,787...71,142,916
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Snora21
small nucleolar RNA, H/ACA box 21
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORA21 mRNA
CTD
PMID:25075043
NCBI chr 5:164,341,679...164,341,814
Ensembl chr10:82,775,114...82,775,249
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Snora26
small nucleolar RNA, H/ACA box 26
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORA26 mRNA
CTD
PMID:25075043
NCBI chr 5:43,082,153...43,082,272
Ensembl chr14:34,127,640...34,127,760
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Snora3a
small nucleolar RNA, H/ACA box 3A
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORA3 mRNA
CTD
PMID:25075043
NCBI chr 7:125,820,534...125,820,664
Ensembl chr 1:163,540,664...163,540,793
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Snora44
small nucleolar RNA, H/ACA box 44
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORA44 mRNA
CTD
PMID:25075043
NCBI chr 5:88,950,502...88,950,630
Ensembl chr 4:126,415,989...126,416,119
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Snora61
small nucleolar RNA, H/ACA box 61
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORA61 mRNA
CTD
PMID:25075043
NCBI chr 5:149,790,438...149,790,567
Ensembl chr 5:144,506,420...144,506,549
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Snora73b
small nucleolar RNA, H/ACA box 73b
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORA73B mRNA
CTD
PMID:25075043
NCBI chr 5:149,829,190...149,829,393
Ensembl chr 5:144,545,179...144,545,382
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Snora75
small nucleolar RNA, H/ACA box 75
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORA75 mRNA
CTD
PMID:25075043
NCBI chr 9:94,448,219...94,448,355
Ensembl chr 9:87,000,248...87,000,384
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Snord22
small nucleolar RNA, C/D box 22
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORD22 mRNA
CTD
PMID:25075043
NCBI chr11:22,544,203...22,544,327
Ensembl chr11:9,097,799...9,097,923
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Snord34
small nucleolar RNA, C/D box 34
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORD34 mRNA
CTD
PMID:25075043
NCBI chr 8:123,923,964...123,924,030
Ensembl chr 8:115,045,817...115,045,883
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Snord52
small nucleolar RNA, C/D box 52
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORD52 mRNA
CTD
PMID:25075043
NCBI chr20:3,883,057...3,883,122
Ensembl chr20:3,878,412...3,878,477
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Snord82
small nucleolar RNA, C/D box 82
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORD82 mRNA
CTD
PMID:25075043
NCBI chr 9:94,452,486...94,452,557
Ensembl chr 9:87,004,515...87,004,586
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Snord87
small nucleolar RNA, C/D box 87
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORD87 mRNA
CTD
PMID:25075043
NCBI chr 5:14,080,356...14,080,440
Ensembl chr 5:9,297,489...9,297,573
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Snord95
small nucleolar RNA, C/D box 95
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORD95 mRNA
CTD
PMID:25075043
NCBI chr10:33,673,118...33,673,185
Ensembl chr10:33,171,983...33,172,050
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Snord96a
small nucleolar RNA, C/D box 96A
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORD96A mRNA
CTD
PMID:25075043
NCBI chr10:33,672,228...33,672,307
Ensembl chr10:33,171,093...33,171,172
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Snrpd2
small nuclear ribonucleoprotein D2 polypeptide
decreases expression
ISO
alpha phellandrene results in decreased expression of SNRPD2 mRNA
CTD
PMID:25075043
NCBI chr 1:87,926,030...87,929,259
Ensembl chr 1:78,798,377...78,803,351 Ensembl chr20:78,798,377...78,803,351
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Sp100
SP100 nuclear antigen
increases expression
ISO
alpha phellandrene results in increased expression of SP100 mRNA
CTD
PMID:25075043
NCBI chr 9:93,758,975...93,825,068
Ensembl chr 9:86,311,032...86,377,034
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Sp140
SP140 nuclear body protein
increases expression
ISO
alpha phellandrene results in increased expression of SP140 mRNA
CTD
PMID:25075043
NCBI chr 9:93,672,536...93,722,596
Ensembl chr 9:86,224,513...86,274,542
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Spc25
SPC25 component of NDC80 kinetochore complex
increases expression
ISO
alpha phellandrene results in increased expression of SPC25 mRNA
CTD
PMID:25075043
NCBI chr 3:74,337,872...74,396,825
Ensembl chr 3:53,975,704...53,988,959
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Spred3
sprouty-related, EVH1 domain containing 3
increases expression
ISO
alpha phellandrene results in increased expression of SPRED3 mRNA
CTD
PMID:25075043
NCBI chr 1:93,586,259...93,597,692
Ensembl chr 1:84,459,314...84,470,249
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Sri
sorcin
increases expression
ISO
alpha phellandrene results in increased expression of SRI mRNA
CTD
PMID:25075043
NCBI chr 4:26,928,338...26,952,980
Ensembl chr 4:25,966,750...25,998,077
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Srm
spermidine synthase
decreases expression
ISO
alpha phellandrene results in decreased expression of SRM mRNA
CTD
PMID:25075043
NCBI chr 5:164,309,002...164,312,203
Ensembl chr 5:159,025,873...159,029,405
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Srr
serine racemase
increases expression
ISO
alpha phellandrene results in increased expression of SRR mRNA
CTD
PMID:25075043
NCBI chr10:60,267,936...60,285,094
Ensembl chr10:59,769,571...59,787,011
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Srsf7
serine and arginine rich splicing factor 7
decreases expression
ISO
alpha phellandrene results in decreased expression of SRSF7 mRNA
CTD
PMID:25075043
NCBI chr 6:20,564,035...20,571,205
Ensembl chr 6:14,811,808...14,818,965
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Ssr4
signal sequence receptor subunit 4
decreases expression
ISO
alpha phellandrene results in decreased expression of SSR4 mRNA
CTD
PMID:25075043
NCBI chr X:156,675,658...156,679,545
Ensembl chr X:151,524,009...151,528,202
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St8sia5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
decreases expression
ISO
alpha phellandrene results in decreased expression of ST8SIA5 mRNA
CTD
PMID:25075043
NCBI chr18:73,010,235...73,072,984
Ensembl chr18:70,736,602...70,797,789
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Stard3nl
STARD3 N-terminal like
increases expression
ISO
alpha phellandrene results in increased expression of STARD3NL mRNA
CTD
PMID:25075043
NCBI chr17:50,278,859...50,312,864
Ensembl chr17:45,583,266...45,617,226
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Stard5
StAR-related lipid transfer domain containing 5
increases expression
ISO
alpha phellandrene results in increased expression of STARD5 mRNA
CTD
PMID:25075043
NCBI chr 1:147,015,304...147,025,170
Ensembl chr 1:137,606,177...137,616,469
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Stat1
signal transducer and activator of transcription 1
increases expression
ISO
alpha phellandrene results in increased expression of STAT1 mRNA
CTD
PMID:25075043
NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540
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Stat2
signal transducer and activator of transcription 2
increases expression
ISO
alpha phellandrene results in increased expression of STAT2 mRNA
CTD
PMID:25075043
NCBI chr 7:1,287,025...1,302,858
Ensembl chr 7:702,495...718,967
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Supv3l1
Suv3 like RNA helicase
decreases expression
ISO
alpha phellandrene results in decreased expression of SUPV3L1 mRNA
CTD
PMID:25075043
NCBI chr20:30,921,248...30,941,779
Ensembl chr20:30,378,550...30,399,054
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Taf1d
TATA-box binding protein associated factor, RNA polymerase I subunit D
decreases expression
ISO
alpha phellandrene results in decreased expression of TAF1D mRNA
CTD
PMID:25075043
NCBI chr 8:20,427,894...20,438,046
Ensembl chr 8:12,146,605...12,156,618
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Tbxas1
thromboxane A synthase 1
decreases expression
ISO
alpha phellandrene results in decreased expression of TBXAS1 mRNA
CTD
PMID:25075043
NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:67,665,007...67,837,096
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Tceanc
transcription elongation factor A N-terminal and central domain containing
increases expression
ISO
alpha phellandrene results in increased expression of TCEANC mRNA
CTD
PMID:25075043
NCBI chr X:31,587,207...31,592,694
Ensembl chr X:27,952,457...27,960,940
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Tcp11l2
t-complex 11 like 2
increases expression
ISO
alpha phellandrene results in increased expression of TCP11L2 mRNA
CTD
PMID:25075043
NCBI chr 7:21,037,955...21,072,857
Ensembl chr 7:19,150,252...19,185,095
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Tctn3
tectonic family member 3
increases expression
ISO
alpha phellandrene results in increased expression of TCTN3 mRNA
CTD
PMID:25075043
NCBI chr 1:249,363,428...249,374,698
Ensembl chr 1:239,415,203...239,425,272
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Tdrd7
tudor domain containing 7
increases expression
ISO
alpha phellandrene results in increased expression of TDRD7 mRNA
CTD
PMID:25075043
NCBI chr 5:65,034,317...65,108,165
Ensembl chr 5:60,238,678...60,312,544
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Tepsin
TEPSIN, adaptor related protein complex 4 accessory protein
decreases expression
ISO
alpha phellandrene results in decreased expression of TEPSIN mRNA
CTD
PMID:25075043
NCBI chr10:105,872,363...105,879,731
Ensembl chr10:105,373,941...105,382,266
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Tesk2
testis associated actin remodelling kinase 2
increases expression
ISO
alpha phellandrene results in increased expression of TESK2 mRNA
CTD
PMID:25075043
NCBI chr 5:135,415,352...135,507,226
Ensembl chr 5:130,185,033...130,271,292
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Tfap4
transcription factor AP-4
decreases expression
ISO
alpha phellandrene results in decreased expression of TFAP4 mRNA
CTD
PMID:25075043
NCBI chr10:11,507,242...11,525,794
Ensembl chr10:11,002,911...11,019,386
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Thg1l
tRNA-histidine guanylyltransferase 1-like
decreases expression
ISO
alpha phellandrene results in decreased expression of THG1L mRNA
CTD
PMID:25075043
NCBI chr10:30,889,259...30,897,903
Ensembl chr10:30,387,940...30,396,687
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Timm10
translocase of inner mitochondrial membrane 10
decreases expression
ISO
alpha phellandrene results in decreased expression of TIMM10 mRNA
CTD
PMID:25075043
NCBI chr 3:90,315,048...90,318,613
Ensembl chr 3:69,908,456...69,911,940
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Tmem120a
transmembrane protein 120A
decreases expression
ISO
alpha phellandrene results in decreased expression of TMEM120A mRNA
CTD
PMID:25075043
NCBI chr12:26,578,859...26,587,524
Ensembl chr12:20,942,439...20,990,316
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Tmem97
transmembrane protein 97
decreases expression
ISO
alpha phellandrene results in decreased expression of TMEM97 mRNA
CTD
PMID:25075043
NCBI chr10:63,936,276...63,945,359
Ensembl chr10:63,438,222...63,589,730
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Tmsb10
thymosin, beta 10
increases expression
ISO
alpha phellandrene results in increased expression of TMSB10 mRNA
CTD
PMID:25075043
NCBI chr 4:106,568,080...106,569,210
Ensembl chr 4:105,009,212...105,011,028
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Tmsb4x
thymosin beta 4, X-linked
increases expression
ISO
alpha phellandrene results in increased expression of TMSB4X mRNA
CTD
PMID:25075043
NCBI chr X:30,761,611...30,763,612
Ensembl chr X:27,128,610...27,146,667 Ensembl chr10:27,128,610...27,146,667
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Tp53
tumor protein p53
decreases expression increases expression increases phosphorylation affects localization
ISO
alpha phellandrene results in decreased expression of TRP53 protein alpha phellandrene results in increased expression of TRP53 protein modified form alpha phellandrene results in increased phosphorylation of TRP53 protein alpha phellandrene affects the localization of TP53 protein
CTD
PMID:24861204 PMID:25649747
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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Tpd52
tumor protein D52
increases expression
ISO
alpha phellandrene results in increased expression of TPD52 mRNA
CTD
PMID:25075043
NCBI chr 2:94,642,514...94,723,442
Ensembl chr 2:92,735,620...92,816,622
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Tpm4
tropomyosin 4
increases expression
ISO
alpha phellandrene results in increased expression of TPM4 mRNA
CTD
PMID:25075043
NCBI chr16:17,718,442...17,732,483
Ensembl chr16:17,683,195...17,705,984
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Trim21
tripartite motif-containing 21
increases expression
ISO
alpha phellandrene results in increased expression of TRIM21 mRNA
CTD
PMID:25075043
NCBI chr 1:166,376,829...166,399,441
Ensembl chr 1:156,964,913...156,987,440
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Tspoap1
TSPO associated protein 1
increases expression
ISO
alpha phellandrene results in increased expression of TSPOAP1 mRNA
CTD
PMID:25075043
NCBI chr10:73,053,414...73,083,640
Ensembl chr10:72,560,980...72,586,412
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Tsr1
TSR1, ribosome maturation factor
decreases expression
ISO
alpha phellandrene results in decreased expression of TSR1 mRNA
CTD
PMID:25075043
NCBI chr10:60,258,790...60,270,238
Ensembl chr10:59,760,409...59,771,864
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Tstd3
thiosulfate sulfurtransferase like domain containing 3
increases expression
ISO
alpha phellandrene results in increased expression of TSTD3 mRNA
CTD
PMID:25075043
NCBI chr 5:40,091,438...40,101,509
Ensembl chr 5:35,294,645...35,304,101
G
Ttc27
tetratricopeptide repeat domain 27
decreases expression
ISO
alpha phellandrene results in decreased expression of TTC27 mRNA
CTD
PMID:25075043
NCBI chr 6:26,310,696...26,454,045
Ensembl chr 6:20,558,756...20,702,115
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Ubash3a
ubiquitin associated and SH3 domain containing, A
decreases expression
ISO
alpha phellandrene results in decreased expression of UBASH3A mRNA
CTD
PMID:25075043
NCBI chr20:9,292,819...9,336,036
Ensembl chr20:9,292,139...9,329,224
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Ube2h
ubiquitin-conjugating enzyme E2H
increases expression
ISO
alpha phellandrene results in increased expression of UBE2H mRNA
CTD
PMID:25075043
NCBI chr 4:59,802,102...59,897,583
Ensembl chr 4:58,834,674...58,930,156
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Urb2
URB2 ribosome biogenesis homolog
decreases expression
ISO
alpha phellandrene results in decreased expression of URB2 mRNA
CTD
PMID:25075043
NCBI chr19:68,908,466...68,934,058
Ensembl chr19:52,011,112...52,036,597
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Usp18
ubiquitin specific peptidase 18
increases expression
ISO
alpha phellandrene results in increased expression of USP18 mRNA
CTD
PMID:25075043
NCBI chr 4:156,143,770...156,171,292
Ensembl chr 4:154,471,592...154,499,144
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Usp22
ubiquitin specific peptidase 22
increases expression
ISO
alpha phellandrene results in increased expression of USP22 mRNA
CTD
PMID:25075043
NCBI chr10:46,328,092...46,354,939
Ensembl chr10:45,828,622...45,855,497
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Usp36
ubiquitin specific peptidase 36
decreases expression
ISO
alpha phellandrene results in decreased expression of USP36 mRNA
CTD
PMID:25075043
NCBI chr10:103,995,970...104,027,492
Ensembl chr10:103,497,349...103,528,877
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Utp20
UTP20 small subunit processome component
decreases expression
ISO
alpha phellandrene results in decreased expression of UTP20 mRNA
CTD
PMID:25075043
NCBI chr 7:25,022,029...25,103,024
Ensembl chr 7:23,134,637...23,215,632
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Wdr12
WD repeat domain 12
decreases expression
ISO
alpha phellandrene results in decreased expression of WDR12 mRNA
CTD
PMID:25075043
NCBI chr 9:68,969,547...68,996,811
Ensembl chr 9:61,475,517...61,502,469
G
Wdr3
WD repeat domain 3
decreases expression
ISO
alpha phellandrene results in decreased expression of WDR3 mRNA
CTD
PMID:25075043
NCBI chr 2:190,194,474...190,217,087
Ensembl chr 2:187,505,816...187,528,432
G
Wdr74
WD repeat domain 74
decreases expression
ISO
alpha phellandrene results in decreased expression of WDR74 mRNA
CTD
PMID:25075043
NCBI chr 1:215,060,901...215,065,687
Ensembl chr 1:205,631,824...205,636,563
G
Wdr75
WD repeat domain 75
decreases expression
ISO
alpha phellandrene results in decreased expression of WDR75 mRNA
CTD
PMID:25075043
NCBI chr 9:55,395,232...55,425,412
Ensembl chr 9:47,903,200...47,933,399
G
Wdsub1
WD repeat, sterile alpha motif and U-box domain containing 1
increases expression
ISO
alpha phellandrene results in increased expression of WDSUB1 mRNA
CTD
PMID:25075043
NCBI chr 3:64,749,118...64,781,525
Ensembl chr 3:44,340,415...44,370,891
G
Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
alpha phellandrene results in increased expression of WIPI1 mRNA
CTD
PMID:25075043
NCBI chr10:95,042,451...95,079,679
Ensembl chr10:94,542,946...94,579,846
G
Xaf1
XIAP associated factor 1
increases expression
ISO
alpha phellandrene results in increased expression of XAF1 mRNA
CTD
PMID:25075043
NCBI chr10:57,415,935...57,428,348
Ensembl chr10:56,917,121...56,929,770
G
Yars2
tyrosyl-tRNA synthetase 2
decreases expression
ISO
alpha phellandrene results in decreased expression of YARS2 mRNA
CTD
PMID:25075043
NCBI chr11:98,136,530...98,142,320
Ensembl chr11:84,624,369...84,638,125
G
Zbp1
Z-DNA binding protein 1
increases expression
ISO
alpha phellandrene results in increased expression of ZBP1 mRNA
CTD
PMID:25075043
NCBI chr 3:182,411,665...182,427,604
Ensembl chr 3:161,993,351...162,003,870
G
Zfp26
zinc finger protein 26
decreases expression
ISO
alpha phellandrene results in decreased expression of ZFP882 mRNA
CTD
PMID:25075043
NCBI chr 8:27,235,912...27,261,879
Ensembl chr 8:18,965,271...18,988,325
G
Zfp260
zinc finger protein 260
increases expression
ISO
alpha phellandrene results in increased expression of ZFP260 mRNA
CTD
PMID:25075043
NCBI chr 1:94,469,861...94,477,377
Ensembl chr 1:85,336,618...85,350,067
G
Zfp346
zinc finger protein 346
decreases expression
ISO
alpha phellandrene results in decreased expression of ZFP346 mRNA
CTD
PMID:25075043
NCBI chr17:9,498,933...9,528,824
Ensembl chr17:9,493,803...9,523,635
G
Zfp39
zinc finger protein 39
increases expression
ISO
alpha phellandrene results in increased expression of ZFP719 mRNA
CTD
PMID:25075043
NCBI chr10:44,156,031...44,179,332
Ensembl chr10:43,656,444...43,679,743
G
Acaca
acetyl-CoA carboxylase alpha
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of ACACA mRNA
CTD
PMID:38000518
NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,014,170...69,276,457
G
Acacb
acetyl-CoA carboxylase beta
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of ACACB mRNA
CTD
PMID:38000518
NCBI chr12:48,026,394...48,138,214
Ensembl chr12:42,366,548...42,457,655
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Acly
ATP citrate lyase
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of ACLY mRNA
CTD
PMID:38000518
NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,412,049...85,463,320
G
Acta2
actin alpha 2, smooth muscle
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of ACTA2 mRNA
CTD
PMID:38000518
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of AHR mRNA
CTD
PMID:38000518
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of AKT1 mRNA
CTD
PMID:38000518
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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Cat
catalase
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of CAT mRNA
CTD
PMID:38000518
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
G
Ccn2
cellular communication network factor 2
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of CTGF mRNA
CTD
PMID:38000518
NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734
G
Col1a1
collagen type I alpha 1 chain
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of COL1A1 mRNA
CTD
PMID:38000518
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
G
Col1a2
collagen type I alpha 2 chain
affects expression
ISO
Camphor analog affects the expression of COL1A2 mRNA
CTD
PMID:24704097
NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867
G
Cpt1a
carnitine palmitoyltransferase 1A
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of CPT1A mRNA
CTD
PMID:38000518
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055
G
Cpt2
carnitine palmitoyltransferase 2
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of CPT2 mRNA
CTD
PMID:38000518
NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:122,664,677...122,682,095
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of CYP1A1 mRNA
CTD
PMID:38000518
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
decreases activity
EXP
Camphor results in decreased activity of CYP2B1 protein
CTD
PMID:9242356
NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions
ISO
Camphor inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]
CTD
PMID:18611395
NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
G
Dgat1
diacylglycerol O-acyltransferase 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of DGAT1 mRNA
CTD
PMID:38000518
NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:108,218,524...108,234,299
G
Esr1
estrogen receptor 1
multiple interactions
ISO
Camphor binds to and results in increased activity of ESR1 protein
CTD
PMID:27633901
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
G
Fasn
fatty acid synthase
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of FASN mRNA
CTD
PMID:38000518
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
G
Foxo1
forkhead box O1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of FOXO1 mRNA
CTD
PMID:38000518
NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
G
Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
multiple interactions
ISO
Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:15588619
NCBI chr10:27,096,731...27,152,563
Ensembl chr10:26,595,160...26,650,864
G
Gabrb2
gamma-aminobutyric acid type A receptor subunit beta 2
multiple interactions
ISO
Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:15588619
NCBI chr10:27,438,127...27,657,680
Ensembl chr10:26,936,551...27,151,251
G
Gabrg2
gamma-aminobutyric acid type A receptor subunit gamma 2
multiple interactions
ISO
Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:15588619
NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,374,694...26,464,346
G
Gpx1
glutathione peroxidase 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of GPX1 mRNA
CTD
PMID:38000518
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
G
Gsr
glutathione-disulfide reductase
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of GSR mRNA
CTD
PMID:38000518
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
G
Mlycd
malonyl-CoA decarboxylase
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of MLYCD mRNA
CTD
PMID:38000518
NCBI chr19:64,356,582...64,372,447
Ensembl chr19:47,447,970...47,463,793
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Mpo
myeloperoxidase
multiple interactions
ISO
Camphor inhibits the reaction [cinnamaldehyde results in increased activity of MPO protein]
CTD
PMID:21466812
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of NFE2L2 mRNA
CTD
PMID:38000518
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
G
Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of NFKB1 mRNA
CTD
PMID:38000518
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
G
Pgr
progesterone receptor
multiple interactions
ISO
Camphor binds to and results in decreased activity of PGR protein
CTD
PMID:27633901
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
G
Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of PPARA mRNA
CTD
PMID:38000518
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
G
Ptgs1
prostaglandin-endoperoxide synthase 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of PTGS1 mRNA
CTD
PMID:38000518
NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:19,584,015...19,605,586
G
Runx2
RUNX family transcription factor 2
affects expression
ISO
Camphor analog affects the expression of RUNX2 mRNA
CTD
PMID:24704097
NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167
G
Snai1
snail family transcriptional repressor 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of SNAI1 mRNA
CTD
PMID:38000518
NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969
G
Sod1
superoxide dismutase 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of SOD1 mRNA
CTD
PMID:38000518
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
G
Sparc
secreted protein acidic and cysteine rich
affects expression
ISO
Camphor analog affects the expression of SPARC mRNA
CTD
PMID:24704097
NCBI chr10:40,017,065...40,038,816
Ensembl chr10:39,516,406...39,538,396
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of TGFB1 mRNA
CTD
PMID:38000518
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
G
Trpv1
transient receptor potential cation channel, subfamily V, member 1
multiple interactions
EXP
Lidocaine promotes the reaction [Camphor results in increased activity of TRPV1 protein]
CTD
PMID:18172555
NCBI chr10:58,349,936...58,375,021
Ensembl chr10:57,851,428...57,876,513
G
Trpv3
transient receptor potential cation channel, subfamily V, member 3
increases activity multiple interactions
ISO
Camphor results in increased activity of TRPV3 protein isopentenyl pyrophosphate inhibits the reaction [Camphor results in increased activity of TRPV3 protein]
CTD
PMID:21353389
NCBI chr10:58,382,054...58,413,657
Ensembl chr10:57,883,546...57,913,296
G
Zeb1
zinc finger E-box binding homeobox 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of ZEB1 mRNA
CTD
PMID:38000518
NCBI chr17:56,644,397...56,811,155
Ensembl chr17:51,948,948...52,115,214
G
Zeb2
zinc finger E-box binding homeobox 2
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of ZEB2 mRNA
CTD
PMID:38000518
NCBI chr 3:49,624,028...49,754,323
Ensembl chr 3:29,218,301...29,345,157
G
Bak1
BCL2-antagonist/killer 1
increases expression
ISO
perillyl alcohol results in increased expression of BAK1 protein
CTD
PMID:12530055
NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of BAX protein]
CTD
PMID:19161993
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein]
CTD
PMID:19161993
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Cat
catalase
multiple interactions
ISO EXP
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein] perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of CAT protein]
CTD
PMID:19161993 PMID:20923693
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
G
Ccna2
cyclin A2
decreases expression
ISO
perillyl alcohol results in decreased expression of CCNA2 protein
CTD
PMID:17138864
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
G
Ccnb1
cyclin B1
decreases expression
ISO
perillyl alcohol results in decreased expression of CCNB1 protein
CTD
PMID:17138864
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
G
Cdk2
cyclin dependent kinase 2
decreases expression multiple interactions
ISO
perillyl alcohol results in decreased expression of CDK2 protein perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
CTD
PMID:17138864
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases response to substance increases expression multiple interactions
ISO
CDKN1A protein results in increased susceptibility to perillyl alcohol perillyl alcohol results in increased expression of CDKN1A protein perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]
CTD
PMID:17138864
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
G
Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression increases response to substance multiple interactions
ISO
perillyl alcohol results in increased expression of CDKN1B protein CDKN1B protein results in increased susceptibility to perillyl alcohol perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
CTD
PMID:17138864
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
G
Fbxo32
F-box protein 32
increases expression
ISO
perillyl alcohol results in increased expression of FBXO32 mRNA; perillyl alcohol results in increased expression of FBXO32 protein
CTD
PMID:19406843
NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:89,730,232...89,765,436
G
Fnta
farnesyltransferase, CAAX box, subunit alpha
multiple interactions
EXP
[Vitamin A co-treated with perillyl alcohol] results in decreased expression of FNTA protein
CTD
PMID:15959631
NCBI chr16:72,767,864...72,786,193
Ensembl chr16:66,065,132...66,083,460
G
Fntb
farnesyltransferase, CAAX box, subunit beta
multiple interactions increases expression decreases expression
EXP
[perillyl alcohol co-treated with Vitamin A] results in decreased expression of FNTB mRNA perillyl alcohol results in increased expression of FNTB protein perillyl alcohol results in decreased expression of FNTB mRNA
CTD
PMID:15959631
NCBI chr 6:101,269,657...101,352,716
Ensembl chr 6:95,470,683...95,619,586
G
Gsr
glutathione-disulfide reductase
multiple interactions
ISO EXP
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GSR protein] perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of GSR protein]
CTD
PMID:19161993 PMID:20923693
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
G
H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
multiple interactions
EXP
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of H6PD protein]
CTD
PMID:20923693
NCBI chr 5:165,717,456...165,753,158
Ensembl chr 5:160,438,697...160,470,171
G
Ivl
involucrin
decreases expression
ISO
perillyl alcohol results in decreased expression of IVL protein
CTD
PMID:10769631
NCBI chr 2:180,842,307...180,854,646
Ensembl chr 2:178,147,061...178,149,100
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
CTD
PMID:19161993
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
CTD
PMID:19161993
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
G
Odc1
ornithine decarboxylase 1
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]
CTD
PMID:19161993
NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:40,329,964...40,336,440
G
Raf1
Raf-1 proto-oncogene, serine/threonine kinase
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RAF1 protein]
CTD
PMID:19161993
NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317
G
Rap1a
RAP1A, member of RAS oncogene family
multiple interactions increases expression
ISO
Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RAP1A protein]
CTD
PMID:12671036
NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:193,208,635...193,286,501
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
perillyl alcohol inhibits the reaction [Ethanol results in increased activity of RELA protein]
CTD
PMID:20923693
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
G
Rhoa
ras homolog family member A
multiple interactions increases expression
ISO EXP
Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOA protein] [perillyl alcohol co-treated with Vitamin A] results in increased expression of RHOA mRNA
CTD
PMID:12671036 PMID:15959631
NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746
G
Rhob
ras homolog family member B
increases expression multiple interactions
EXP ISO
perillyl alcohol results in increased expression of RHOB mRNA; perillyl alcohol results in increased expression of RHOB protein [perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB mRNA; [perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB protein Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOB protein]
CTD
PMID:12671036 PMID:15959631
NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:31,363,548...31,366,108
G
Tnf
tumor necrosis factor
multiple interactions
EXP
perillyl alcohol inhibits the reaction [Ethanol results in increased expression of TNF protein]
CTD
PMID:20923693
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Cxcl2
C-X-C motif chemokine ligand 2
increases expression multiple interactions
ISO
13,14-dihydro-15-ketoprostaglandin D2 results in increased expression of CXCL2 protein 13,14-dihydro-15-ketoprostaglandin D2 promotes the reaction [Flutamide results in increased expression of CXCL2 mRNA]
CTD
PMID:21094227 PMID:21735453
NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075
G
Gata3
GATA binding protein 3
multiple interactions
ISO
13,14-dihydro-15-ketoprostaglandin D2 promotes the reaction [Flutamide results in increased expression of GATA3 mRNA]
CTD
PMID:21735453
NCBI chr17:73,544,234...73,575,670
Ensembl chr17:68,643,873...68,665,391
G
Il4
interleukin 4
multiple interactions
ISO
13,14-dihydro-15-ketoprostaglandin D2 promotes the reaction [Flutamide results in increased expression of IL4 protein]
CTD
PMID:21735453
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
G
Ptgdr
prostaglandin D2 receptor
multiple interactions
ISO
13,14-dihydro-15-ketoprostaglandin D2 binds to and results in increased activity of PTGDR protein; 13,14-dihydro-15-ketoprostaglandin D2 inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]
CTD
PMID:9579725
NCBI chr15:19,790,499...19,797,873
Ensembl chr15:17,360,304...17,367,679
G
Ptgdr2
prostaglandin D2 receptor 2
multiple interactions
EXP ISO
13,14-dihydro-15-ketoprostaglandin D2 binds to and results in increased activity of PTGDR2 protein 13,14-dihydro-15-ketoprostaglandin D2 binds to and results in increased activity of PTGDR2 protein; ramatroban inhibits the reaction [13,14-dihydro-15-ketoprostaglandin D2 binds to and results in increased activity of PTGDR2 protein] 13,14-dihydro-15-ketoprostaglandin D2 inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]
CTD
PMID:12721327 PMID:15528449 PMID:16256979
NCBI chr 1:217,010,183...217,015,044
Ensembl chr 1:207,587,917...207,589,213
G
Bdnf
brain-derived neurotrophic factor
increases expression multiple interactions
EXP
9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of BDNF mRNA Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of BDNF mRNA]
CTD
PMID:22982731
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
G
Gdnf
glial cell derived neurotrophic factor
increases expression multiple interactions
EXP
9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA]; NFE2L2 protein affects the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA]
CTD
PMID:22982731
NCBI chr 2:58,621,327...58,647,242
Ensembl chr 2:56,895,010...56,917,209
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
NFE2L2 protein affects the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA]
CTD
PMID:22982731
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
G
Ngf
nerve growth factor
increases expression multiple interactions
EXP
9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of NGF mRNA Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of NGF mRNA]
CTD
PMID:22982731
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452
G
Abcc1
ATP binding cassette subfamily C member 1
increases transport multiple interactions affects export affects glutathionylation
ISO
ABCC1 protein results in increased transport of 15-deoxy-delta(12,14)-prostaglandin J2 metabolite [ABCC1 protein results in increased transport of 15-deoxy-delta(12,14)-prostaglandin J2 metabolite] affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein] ABCC1 protein affects the export of 15-deoxy-delta(12,14)-prostaglandin J2 analog ABCC1 protein affects the glutathionylation of 15-deoxy-delta(12,14)-prostaglandin J2
CTD
PMID:14979731 PMID:21728338
NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114
G
Abcc3
ATP binding cassette subfamily C member 3
affects export
ISO
ABCC3 protein affects the export of 15-deoxy-delta(12,14)-prostaglandin J2 analog
CTD
PMID:14979731
NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595
G
Acaa2
acetyl-CoA acyltransferase 2
multiple interactions
ISO
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACAA2 mRNA
CTD
PMID:34323617
NCBI chr18:70,620,310...70,648,417
Ensembl chr18:68,345,012...68,373,249
G
Adipoq
adiponectin, C1Q and collagen domain containing
multiple interactions
ISO
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA
CTD
PMID:34323617
NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564
G
Agt
angiotensinogen
multiple interactions
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in decreased expression of PPARG protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]
CTD
PMID:18278065
NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977
G
Akr1c3
aldo-keto reductase family 1, member C3
multiple interactions
ISO
[Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]] which results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2
CTD
PMID:19997560
NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of AKT1 protein
CTD
PMID:16611854
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
G
Bglap
bone gamma-carboxyglutamate protein
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of BGLAP mRNA
CTD
PMID:12021203
NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:173,838,518...173,839,495
G
Birc2
baculoviral IAP repeat-containing 2
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of BIRC2 protein
CTD
PMID:15498850
NCBI chr 8:13,253,697...13,273,672
Ensembl chr 8:4,968,842...4,988,732
G
Birc3
baculoviral IAP repeat-containing 3
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of BIRC3 protein
CTD
PMID:15498850
NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802
G
Casp3
caspase 3
increases activity multiple interactions increases cleavage
ISO EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of CASP3 protein [delta(12)-prostaglandin J(2) co-treated with 9-deoxy-delta-9-prostaglandin D2 co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in increased cleavage of CASP3 protein 15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of CASP3 protein 15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of and results in increased activity of CASP3 protein
CTD
PMID:11785780 PMID:15498850 PMID:16299251 PMID:23973622
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
G
Casp8
caspase 8
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of and results in increased activity of CASP8 protein
CTD
PMID:15498850
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
G
Casp9
caspase 9
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of and results in increased activity of CASP9 protein
CTD
PMID:15498850
Ensembl chr 5:154,109,046...154,126,626
G
Cat
catalase
multiple interactions
ISO
CAT protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]
CTD
PMID:12847270
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
G
Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Dexamethasone binds to NR3C1 protein] which results in decreased expression of CCL2 protein]
CTD
PMID:15187150
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
G
Ccl5
C-C motif chemokine ligand 5
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]
CTD
PMID:23688403
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
G
Ccn2
cellular communication network factor 2
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of and results in increased secretion of CCN2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]; SMAD2 protein modified form affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2]]
CTD
PMID:19429239
NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734
G
Ccna2
cyclin A2
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCNA2 protein
CTD
PMID:15729575
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
G
Ccnb1
cyclin B1
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCNB1 protein
CTD
PMID:15729575
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
G
Ccnd3
cyclin D3
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCND3 protein
CTD
PMID:15729575
NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371
G
Ccne1
cyclin E1
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCNE1 protein
CTD
PMID:15729575
NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
G
Cdk2
cyclin dependent kinase 2
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CDK2 protein
CTD
PMID:15729575
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of CDKN1A 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CDKN1A protein
CTD
PMID:15254749 PMID:15729575
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
G
Cdkn1b
cyclin-dependent kinase inhibitor 1B
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CDKN1B protein
CTD
PMID:15729575
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
G
Cebpa
CCAAT/enhancer binding protein alpha
increases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of CEBPA mRNA
CTD
PMID:12021203
NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412
G
Cflar
CASP8 and FADD-like apoptosis regulator
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CFLAR protein
CTD
PMID:15498850
NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034
G
Chuk
component of inhibitor of nuclear factor kappa B kinase complex
multiple interactions
ISO EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of CHUK protein] 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in increased phosphorylation of CHUK protein]
CTD
PMID:15498850 PMID:22245093
NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065
G
Cidec
cell death-inducing DFFA-like effector c
multiple interactions
ISO
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CIDEC mRNA
CTD
PMID:34323617
NCBI chr 4:148,124,924...148,137,806
Ensembl chr 4:146,569,289...146,582,173
G
Col1a1
collagen type I alpha 1 chain
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of COL1A1 mRNA
CTD
PMID:12021203
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
G
Csf2
colony stimulating factor 2
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2 mRNA]; Dexamethasone promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]]
CTD
PMID:12604364 PMID:14998300
NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199
G
Egr1
early growth response 1
multiple interactions
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of EGR1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Oxygen deficiency results in increased expression of EGR1 mRNA]
CTD
PMID:12468449
NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766
G
Fabp4
fatty acid binding protein 4
multiple interactions increases expression
ISO
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Tretinoin] results in increased expression of FABP4 mRNA [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FABP4 mRNA
CTD
PMID:9543393 PMID:12021203 PMID:16573735 PMID:34323617
NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578
G
Fas
Fas cell surface death receptor
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of FAS mRNA
CTD
PMID:16712844
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions increases expression
ISO EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [FOS protein binds to JUN protein]] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]; U 0126 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]; wortmannin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]
CTD
PMID:11457450 PMID:11687581
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
G
Gclc
glutamate-cysteine ligase, catalytic subunit
multiple interactions increases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]; [ABCC1 protein results in increased transport of 15-deoxy-delta(12,14)-prostaglandin J2 metabolite] affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein] 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein
CTD
PMID:21728338
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
G
Gfap
glial fibrillary acidic protein
increases expression decreases expression multiple interactions
ISO EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GFAP 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of GFAP mRNA 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ochratoxin A results in decreased expression of GFAP mRNA]
CTD
PMID:15254749 PMID:15994020
NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589
G
Gstm1
glutathione S-transferase mu 1
multiple interactions
ISO
GSTM1 protein affects the metabolism of [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Glutathione]
CTD
PMID:14979731
NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411
G
Gstp1
glutathione S-transferase pi 1
increases expression multiple interactions
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 protein Soybean Oil promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 mRNA]; Soybean Oil promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 protein]
CTD
PMID:11600134
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
G
Hdac1
histone deacetylase 1
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HDAC1 mRNA
CTD
PMID:21957481
NCBI chr 5:147,138,328...147,165,387
Ensembl chr 5:141,853,989...141,881,111
G
Hdac2
histone deacetylase 2
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HDAC2 mRNA
CTD
PMID:21957481
NCBI chr20:42,101,815...42,126,486
Ensembl chr20:40,548,250...40,571,609
G
Hdac3
histone deacetylase 3
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HDAC3 mRNA
CTD
PMID:21957481
NCBI chr18:30,021,847...30,041,061
Ensembl chr18:29,770,636...29,793,856
G
Hif1a
hypoxia inducible factor 1 subunit alpha
affects stability multiple interactions increases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 affects the stability of HIF1A protein Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Buthionine Sulfoximine promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Dithiothreitol inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]
CTD
PMID:17658243
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
G
Hmox1
heme oxygenase 1
multiple interactions increases expression
ISO EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein; [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased expression of MMP1 mRNA; [[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein; Acetylcysteine inhibits the reaction [[[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein]; HMOX1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of MMP1 protein]; HSF1 protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 protein ochratoxin A inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]
CTD
PMID:11078701 PMID:15618017 PMID:15994020 PMID:19136476
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
G
Hsf1
heat shock transcription factor 1
multiple interactions increases activity
ISO
HSF1 protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA] 15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of HSF1 protein
CTD
PMID:15618017 PMID:34170685
NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:108,196,056...108,223,011
G
Hspb1
heat shock protein family B (small) member 1
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HSPB1 protein
CTD
PMID:16299251
NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743
G
Ifng
interferon gamma
decreases secretion decreases expression multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased secretion of IFNG protein 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of IFNG protein 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of [STAT1 protein binds to STAT1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased secretion of IFNG protein]; CAT protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Hydrogen Peroxide promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]]; peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased secretion of IFNG protein]
CTD
PMID:12847270 PMID:16844232 PMID:19888466
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
G
Il1a
interleukin 1 alpha
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of IL1A mRNA]
CTD
PMID:14998300
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
G
Il1b
interleukin 1 beta
multiple interactions decreases activity decreases expression
ISO EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein affects the localization of RELA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in decreased abundance of Prostaglandins]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [FOS protein binds to JUN protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of IL1A mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [IL1B protein affects the localization of JUN protein]; Dexamethasone promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]] 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of IL1B protein 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of IL1B protein [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with IL1B protein] results in decreased secretion of IL1B protein
CTD
PMID:11457450 PMID:12604364 PMID:14998300 PMID:15751073 PMID:16461118
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
G
Il1rn
interleukin 1 receptor antagonist
decreases expression
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of IL1RN mRNA
CTD
PMID:15751073
NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445
G
Il4
interleukin 4
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; [Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]
CTD
PMID:23688403
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
G
Il6
interleukin 6
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
CTD
PMID:12604364 PMID:12847270
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
G
Ins1
insulin 1
multiple interactions
ISO
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACAA2 mRNA; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ADIPOQ mRNA; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of CIDEC mRNA; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of FABP4 mRNA; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PLIN1 mRNA; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARA mRNA
CTD
PMID:34323617
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
G
Ins2
insulin 2
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified inhibits the reaction [INS protein results in increased secretion of Glucose]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of INS mRNA]
CTD
PMID:14625208
NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775
G
Irf1
interferon regulatory factor 1
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA]
CTD
PMID:12847270
NCBI chr10:38,417,935...38,424,946
Ensembl chr10:37,916,670...37,924,166
G
Jak2
Janus kinase 2
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]
CTD
PMID:12847270
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [FOS protein binds to JUN protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [IL1B protein affects the localization of JUN protein]
CTD
PMID:11457450
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
G
Klf6
KLF transcription factor 6
multiple interactions
ISO
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein]
CTD
PMID:16611854
NCBI chr17:69,449,483...69,458,478
Ensembl chr17:64,531,463...64,588,570
G
Lep
leptin
increases secretion multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in increased secretion of LEP protein [Dexamethasone co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased secretion of LEP protein
CTD
PMID:11092516
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
G
Lif
LIF, interleukin 6 family cytokine
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]
CTD
PMID:19922793
NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482
G
Lpl
lipoprotein lipase
increases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of LPL mRNA
CTD
PMID:12021203
NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249
G
Mapk1
mitogen activated protein kinase 1
decreases phosphorylation multiple interactions increases phosphorylation
ISO EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of MAPK1 protein 15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK1 protein; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK1 protein] 15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MAPK1 protein; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]
CTD
PMID:11687581 PMID:12083801 PMID:16611854 PMID:19888466
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions decreases phosphorylation increases phosphorylation
EXP ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK3 protein; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK3 protein] 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of MAPK3 protein 15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MAPK3 protein; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]
CTD
PMID:11687581 PMID:12083801 PMID:16611854 PMID:19888466
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
G
Med1
mediator complex subunit 1
multiple interactions
ISO
MED1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]
CTD
PMID:16324150
NCBI chr10:83,641,851...83,685,560
Ensembl chr10:83,145,568...83,189,299
G
Mmp1
matrix metallopeptidase 1
multiple interactions increases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of MMP1 protein; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased expression of MMP1 mRNA; [[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein; Acetylcysteine inhibits the reaction [[[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein]; Cycloheximide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein]; Dactinomycin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein]; Deferoxamine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 mRNA]; Deferoxamine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein]; HMOX1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of MMP1 protein]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 mRNA]
CTD
PMID:19136476
NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097
G
Mmp9
matrix metallopeptidase 9
decreases expression multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of MMP9 mRNA 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of MMP9 protein; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of MMP9 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of MMP9 mRNA]
CTD
PMID:19997048
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
G
Mtor
mechanistic target of rapamycin kinase
multiple interactions
ISO
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MTOR protein
CTD
PMID:16611854
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
G
Nes
nestin
increases expression
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of NES protein
CTD
PMID:15212945
NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:173,438,734...173,447,777
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO EXP
15-deoxy-delta(12,14)-prostaglandin J2 affects the localization of and results in increased activity of NFE2L2 protein; 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of NFE2L2 protein]; NFE2L2 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 mRNA] 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and affects the localization of NFE2L2 protein; manganese chloride inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of NFE2L2 protein]
CTD
PMID:19136476 PMID:21728338 PMID:22245093
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
G
Nfkb1
nuclear factor kappa B subunit 1
decreases localization multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased localization of NFKB1 protein 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]
CTD
PMID:11457450 PMID:16299251
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
G
Nfkbia
NFKB inhibitor alpha
multiple interactions decreases phosphorylation
ISO EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein] 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in increased degradation of NFKBIA protein] 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of NFKBIA protein
CTD
PMID:15498850 PMID:22245093 PMID:23688403
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
G
Nos2
nitric oxide synthase 2
multiple interactions decreases expression decreases activity
EXP ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ochratoxin A results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of NOS2 protein 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of NOS2 mRNA 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of NOS2 protein; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of NOS2 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of NOS2 mRNA] 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA] 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of NOS2 protein
CTD
PMID:11457450 PMID:11890746 PMID:12847270 PMID:15684285 PMID:15994020 PMID:16461118 PMID:19997048 More...
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
G
Nos3
nitric oxide synthase 3
decreases activity
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of NOS3 protein
CTD
PMID:11890746
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
G
Nr3c1
nuclear receptor subfamily 3, group C, member 1
affects activity multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 affects the activity of NR3C1 protein 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Dexamethasone binds to NR3C1 protein] which results in decreased expression of CCL2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Dexamethasone binds to NR3C1 protein]
CTD
PMID:15187150
NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375
G
Park7
Parkinsonism associated deglycase
multiple interactions
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in decreased expression of PARK7 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in decreased expression of PARK7 protein]
CTD
PMID:22245093
NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970
G
Parp1
poly (ADP-ribose) polymerase 1
multiple interactions increases cleavage
EXP ISO
[delta(12)-prostaglandin J(2) co-treated with 9-deoxy-delta-9-prostaglandin D2 co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in increased cleavage of PARP1 protein 15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of PARP1 protein
CTD
PMID:15498850 PMID:23973622
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
G
Pck1
phosphoenolpyruvate carboxykinase 1
increases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PCK1 mRNA
CTD
PMID:9518257
NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:161,930,256...161,936,191
G
Plin1
perilipin 1
multiple interactions
ISO
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PLIN1 mRNA
CTD
PMID:34323617
NCBI chr 1:143,073,612...143,086,199
Ensembl chr 1:133,664,892...133,676,828
G
Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PPARA protein [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of PPARA mRNA
CTD
PMID:9013583 PMID:34323617
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
G
Ppard
peroxisome proliferator-activated receptor delta
increases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PPARD protein
CTD
PMID:17341418
NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,298,785...6,363,968
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions increases activity decreases expression affects expression decreases response to substance increases expression
ISO EXP
15-deoxy-delta(12,14)-prostaglandin J2 affects the localization of and results in increased expression of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in decreased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased localization of and results in increased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [deoxynivalenol results in increased expression of PPARG protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of PPARG mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]; MG 262 promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]; PPARG protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TBXA2R mRNA alternative form] 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of PPARG protein 15-deoxy-delta(12,14)-prostaglandin J2 affects the expression of PPARG PPARG protein mutant form results in decreased susceptibility to 15-deoxy-delta(12,14)-prostaglandin J2 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PPARG mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PPARG protein 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in decreased expression of PPARG protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ochratoxin A results in increased expression of PPARG mRNA] 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; MED1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]
CTD
PMID:9013583 PMID:10662598 PMID:11030710 PMID:12065695 PMID:12604364 PMID:12839938 PMID:12847270 PMID:14625208 PMID:14979731 PMID:14998300 PMID:15212945 PMID:15254749 PMID:15322177 PMID:15491415 PMID:15707588 PMID:15729575 PMID:15866424 PMID:15994020 PMID:16324150 PMID:16499875 PMID:17341418 PMID:18278065 PMID:18485432 PMID:19922793 PMID:23943857 PMID:26172262 PMID:30138673 More...
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
G
Pten
phosphatase and tensin homolog
multiple interactions
ISO
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in increased expression of PTEN protein
CTD
PMID:16611854
NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
G
Ptgdr
prostaglandin D2 receptor
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PTGDR protein; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]
CTD
PMID:9579725
NCBI chr15:19,790,499...19,797,873
Ensembl chr15:17,360,304...17,367,679
G
Ptgdr2
prostaglandin D2 receptor 2
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PTGDR2 protein; ramatroban inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PTGDR2 protein] 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]
CTD
PMID:12721327 PMID:16256979
NCBI chr 1:217,010,183...217,015,044
Ensembl chr 1:207,587,917...207,589,213
G
Ptgs1
prostaglandin-endoperoxide synthase 1
multiple interactions
ISO
PTGS1 protein promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2]
CTD
PMID:17439952
NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:19,584,015...19,605,586
G
Ptgs2
prostaglandin-endoperoxide synthase 2
decreases expression increases expression multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of PTGS2 mRNA 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PTGS2 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of PTGS2 protein; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of PTGS2 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of PTGS2 mRNA]
CTD
PMID:11457450 PMID:12604364 PMID:15254749 PMID:19997048
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
G
Ptpn11
protein tyrosine phosphatase, non-receptor type 11
increases phosphorylation
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of PTPN11 protein
CTD
PMID:12584205
NCBI chr12:41,026,079...41,085,577
Ensembl chr12:35,383,144...35,424,925
G
Raf1
Raf-1 proto-oncogene, serine/threonine kinase
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of and results in decreased phosphorylation of RAF1 protein
CTD
PMID:12083801
NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317
G
Rarb
retinoic acid receptor, beta
increases expression multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of RARB 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ciglitazone promotes the reaction [SR 11237 results in increased expression of RARB protein]]
CTD
PMID:12839938 PMID:15254749
NCBI chr15:10,837,252...11,482,037
Ensembl chr15:8,406,492...9,051,288
G
Rb1
RB transcriptional corepressor 1
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of and results in decreased expression of RB1 protein
CTD
PMID:15729575
NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions decreases activity
ISO EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein affects the localization of RELA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein] 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of RELA protein 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride affects the localization of RELA protein]
CTD
PMID:11457450 PMID:15498850 PMID:20174873 PMID:22245093
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
G
Rig1
RNA sensor RIG-1
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of RIGI mRNA]
CTD
PMID:16303604
NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:55,321,235...55,370,819
G
Rps6ka1
ribosomal protein S6 kinase A1
multiple interactions
ISO
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of RPS6KA1 protein
CTD
PMID:16611854
NCBI chr 5:151,362,819...151,402,064
Ensembl chr 5:146,079,021...146,118,272
G
Rps6kb1
ribosomal protein S6 kinase B1
multiple interactions
ISO
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased expression of TGFB1 mRNA]; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein]
CTD
PMID:16611854
NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
G
Runx2
RUNX family transcription factor 2
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of RUNX2 mRNA
CTD
PMID:12021203
NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167
G
Rxra
retinoid X receptor alpha
increases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of RXRA
CTD
PMID:15254749
NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:10,989,832...11,073,712
G
Serpine1
serpin family E member 1
multiple interactions
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]
CTD
PMID:18278065
NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657
G
Smad2
SMAD family member 2
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; SMAD2 protein modified form affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2]]
CTD
PMID:19429239
NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323
G
Socs1
suppressor of cytokine signaling 1
increases expression
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of SOCS1 mRNA
CTD
PMID:12584205
NCBI chr10:5,389,574...5,391,265
Ensembl chr10:4,882,560...4,884,383
G
Socs3
suppressor of cytokine signaling 3
increases expression
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of SOCS3 mRNA
CTD
PMID:12584205
NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787
G
Spp1
secreted phosphoprotein 1
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of SPP1 mRNA
CTD
PMID:12021203
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162
G
Stat1
signal transducer and activator of transcription 1
multiple interactions
EXP ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of [STAT1 protein binds to STAT1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [peroxyvanadate results in increased phosphorylation of STAT1 protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; CAT protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Hydrogen Peroxide promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]] 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT1 protein]
CTD
PMID:12584205 PMID:12847270
NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540
G
Stat3
signal transducer and activator of transcription 3
multiple interactions
ISO EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; bisphenol A diglycidyl ether inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]] 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein] 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
CTD
PMID:12584205 PMID:12847270 PMID:19922793
NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
G
Tbxa2r
thromboxane A2 receptor
decreases expression multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TBXA2R mRNA alternative form PPARG protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TBXA2R mRNA alternative form]
CTD
PMID:16499875
NCBI chr 7:9,034,077...9,041,489
Ensembl chr 7:8,383,378...8,388,176
G
Tg
thyroglobulin
increases expression multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of TG protein 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [TSHB protein results in increased expression of TG protein]
CTD
PMID:11078701
NCBI chr 7:100,307,349...100,492,246
Ensembl chr 7:98,418,293...98,603,210
G
Tgfb1
transforming growth factor, beta 1
multiple interactions decreases expression decreases response to substance
ISO EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of and results in increased secretion of CCN2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; SMAD2 protein modified form affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2]] 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TGFB1 mRNA 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of TGFB1 protein] 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [Alitretinoin results in decreased expression of TGFB1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[Alitretinoin co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased expression of TGFB1 mRNA]; bisphenol A diglycidyl ether inhibits the reaction [[Alitretinoin co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased expression of TGFB1 mRNA]; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Alitretinoin] results in decreased expression of TGFB1 mRNA] 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased susceptibility to TGFB1 protein
CTD
PMID:16611854 PMID:18278065 PMID:19429239
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
G
Th
tyrosine hydroxylase
increases expression
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of TH protein
CTD
PMID:15212945
NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
G
Tlr2
toll-like receptor 2
multiple interactions decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA] 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TLR2 mRNA
CTD
PMID:20174873
NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630
G
Tnf
tumor necrosis factor
decreases expression multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TNF protein 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD
PMID:12604364 PMID:19888466
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Tshb
thyroid stimulating hormone subunit beta
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [TSHB protein results in increased expression of TG protein]
CTD
PMID:11078701
NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:190,224,676...190,229,559
G
Tslp
thymic stromal lymphopoietin
multiple interactions
ISO
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]
CTD
PMID:23688403
NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,449,844...24,453,548
G
Vim
vimentin
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of VIM
CTD
PMID:15254749
NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
G
Wnt10b
Wnt family member 10B
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of WNT10B mRNA
CTD
PMID:12021203
NCBI chr 7:131,801,046...131,806,850
Ensembl chr 7:129,922,088...129,927,892
G
Xiap
X-linked inhibitor of apoptosis
decreases expression
ISO
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of XIAP protein
CTD
PMID:15498850 PMID:16299251
NCBI chr X:125,756,107...125,803,979
Ensembl chr X:120,897,907...120,934,700
G
Akt1
AKT serine/threonine kinase 1
increases phosphorylation multiple interactions
ISO
16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein EGFR affects the reaction [16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein]
CTD
PMID:15578100
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
G
Bax
BCL2 associated X, apoptosis regulator
increases response to substance affects localization
ISO
BAX results in increased susceptibility to 16,16-Dimethylprostaglandin E2 16,16-Dimethylprostaglandin E2 affects the localization of BAX protein
CTD
PMID:15578100
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
G
Egfr
epidermal growth factor receptor
multiple interactions
ISO
EGFR affects the reaction [16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein]
CTD
PMID:15578100
NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382
G
Hpgd
15-hydroxyprostaglandin dehydrogenase
increases activity
ISO
16,16-Dimethylprostaglandin E2 results in increased activity of HPGD protein
CTD
PMID:14736730
NCBI chr16:38,996,876...39,034,831
Ensembl chr16:33,986,266...34,024,228
G
Mpo
myeloperoxidase
multiple interactions
EXP
16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of MPO protein]
CTD
PMID:11686837 PMID:11855677 PMID:11991626 PMID:18306037
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
G
Nos2
nitric oxide synthase 2
multiple interactions
EXP
16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA]
CTD
PMID:11686837 PMID:11855677 PMID:11991626 PMID:15610444 PMID:18306037
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions increases expression
ISO EXP
Flurbiprofen inhibits the reaction [16,16-Dimethylprostaglandin E2 results in increased expression of PTGS2 mRNA] 16,16-Dimethylprostaglandin E2 inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA]
CTD
PMID:9099957 PMID:15610444
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
G
Tnf
tumor necrosis factor
multiple interactions
ISO
16,16-Dimethylprostaglandin E2 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]
CTD
PMID:9298541
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Casp3
caspase 3
multiple interactions
ISO
cyclopentenone results in increased cleavage of and results in increased activity of CASP3 protein
CTD
PMID:18383863
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
G
Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
ISO
cyclopentenone results in increased expression of CDKN1B
CTD
PMID:16061222
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
G
Rb1
RB transcriptional corepressor 1
decreases phosphorylation
ISO
cyclopentenone results in decreased phosphorylation of RB1 protein
CTD
PMID:16061222
NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
G
Hsd17b2
hydroxysteroid (17-beta) dehydrogenase 2
multiple interactions
ISO
[HSD17B2 protein results in increased metabolism of and results in decreased activity of 2-methoxyestradiol] which results in increased chemical synthesis of 2-methoxyestrone
CTD
PMID:16397246
NCBI chr19:62,662,320...62,733,944
Ensembl chr19:45,753,574...45,825,202
G
Casp3
caspase 3
increases activity
ISO
28-deoxonimbolide results in increased activity of CASP3 protein
CTD
PMID:21381696
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
G
Casp8
caspase 8
increases activity
ISO
28-deoxonimbolide results in increased activity of CASP8 protein
CTD
PMID:21381696
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
G
Casp9
caspase 9
increases activity
ISO
28-deoxonimbolide results in increased activity of CASP9 protein
CTD
PMID:21381696
Ensembl chr 5:154,109,046...154,126,626
G
Ahr
aryl hydrocarbon receptor
increases expression
EXP
4-vinylcyclohexene results in increased expression of AHR mRNA; 4-vinylcyclohexene results in increased expression of AHR protein
CTD
PMID:15710172
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
G
Casp3
caspase 3
increases activity
EXP
4-vinylcyclohexene results in increased activity of CASP3 protein
CTD
PMID:15710172
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
multiple interactions increases metabolic processing
EXP
[CYP2B1 protein results in increased metabolism of 4-vinylcyclohexene] which results in increased abundance of 1,2-epoxy-4-vinylcyclohexane
CTD
PMID:11368546
NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions increases expression increases metabolic processing
EXP ISO
[CYP2E1 protein results in increased metabolism of 4-vinylcyclohexene] which results in increased abundance of 1,2-epoxy-4-vinylcyclohexane 4-vinylcyclohexene results in increased expression of CYP2E1 protein
CTD
PMID:9929517 PMID:11368546
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to AKT1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of AKT1 protein
CTD
PMID:19407222
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
G
Arrb1
arrestin, beta 1
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to IL1R1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to TNFRSF1A protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [ARRB1 protein modified form binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of ARRB1 protein
CTD
PMID:19407222
NCBI chr 1:163,249,654...163,321,711
Ensembl chr 1:153,838,078...153,904,061
G
Axin1
axin 1
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [AXIN1 protein binds to CTNNB1 protein]
CTD
PMID:19407222
NCBI chr10:15,667,894...15,720,092
Ensembl chr10:15,163,684...15,215,615
G
Bad
BCL2-associated agonist of cell death
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAD protein binds to BCL2 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAD protein binds to BCL2L1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of BAD protein
CTD
PMID:19407222
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAX protein binds to BCL2 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAX protein binds to BCL2L1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in increased expression of BAX protein
CTD
PMID:19407222
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAD protein binds to BCL2 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAX protein binds to BCL2 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of BCL2 protein
CTD
PMID:19407222
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Bcl2l1
Bcl2-like 1
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAD protein binds to BCL2L1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAX protein binds to BCL2L1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of BCL2L1 protein
CTD
PMID:19407222
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
G
Casp3
caspase 3
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in increased cleavage of and results in increased activity of CASP3 protein AH 23848 inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased cleavage of CASP3 protein]
CTD
PMID:19407222 PMID:32115946
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
G
Ctnnb1
catenin beta 1
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [AXIN1 protein binds to CTNNB1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [GSK3B protein binds to CTNNB1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in increased degradation of CTNNB1 protein
CTD
PMID:19407222
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
G
Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
multiple interactions
ISO
AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]; AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]; AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 mRNA]; AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]
CTD
PMID:20678559 PMID:28571770
NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
G
Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions
ISO
AH 23848 inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; AH 23848 inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]
CTD
PMID:20093341
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
G
Egfr
epidermal growth factor receptor
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [EGFR protein modified form binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of and results in decreased expression of EGFR protein
CTD
PMID:19407222
NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382
G
Egr1
early growth response 1
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of EGR1 protein
CTD
PMID:19407222
NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of FOS protein
CTD
PMID:19407222
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
G
Gsk3b
glycogen synthase kinase 3 beta
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to AKT1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to MAPK1 protein binds to MAPK3 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [GSK3B protein binds to CTNNB1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of GSK3B protein
CTD
PMID:19407222
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
G
Il1r1
interleukin 1 receptor type 1
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to IL1R1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of IL1R1 protein
CTD
PMID:19407222
NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:42,504,735...42,579,937
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of JUN protein
CTD
PMID:19407222
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
G
Lep
leptin
multiple interactions
ISO
AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]; AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]
CTD
PMID:28571770
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to MAPK1 protein binds to MAPK3 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of MAPK1 protein
CTD
PMID:19407222
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to MAPK1 protein binds to MAPK3 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of MAPK3 protein
CTD
PMID:19407222
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
G
Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
AH 23848 inhibits the reaction [Lipopolysaccharides results in increased expression of MMP9 protein]
CTD
PMID:30269738
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
G
Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of MYC protein
CTD
PMID:19407222
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
G
Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of NFKB1 protein
CTD
PMID:19407222
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
G
Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of NFKBIA protein
CTD
PMID:19407222
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
G
Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in increased cleavage of and results in increased activity of PARP1 protein
CTD
PMID:19407222
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
G
Ptger2
prostaglandin E receptor 2
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [PTGER2 protein binds to SRC protein]
CTD
PMID:19407222
NCBI chr15:20,694,765...20,708,475
Ensembl chr15:18,217,285...18,228,714
G
Ptger4
prostaglandin E receptor 4
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [PTGER4 protein binds to SRC protein]; AH 23848 binds to and results in decreased activity of PTGER4 protein
CTD
PMID:19407222 PMID:30269738
NCBI chr 2:56,061,699...56,074,594
Ensembl chr 2:54,335,424...54,346,670
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]
CTD
PMID:20678559
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of and results in decreased expression of RELA protein
CTD
PMID:19407222
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
G
Sp1
Sp1 transcription factor
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of SP1 protein
CTD
PMID:19407222
NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961
G
Src
SRC proto-oncogene, non-receptor tyrosine kinase
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to IL1R1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to TNFRSF1A protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [ARRB1 protein modified form binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [EGFR protein modified form binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [PTGER2 protein binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [PTGER4 protein binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of SRC protein
CTD
PMID:19407222
NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476
G
Tcf7
transcription factor 7
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of TCF7 protein
CTD
PMID:19407222
NCBI chr10:36,924,363...36,954,279
Ensembl chr10:36,423,445...36,453,535
G
Tcf7l2
transcription factor 7 like 2
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of TCF7L2 protein
CTD
PMID:19407222
NCBI chr 1:264,791,335...264,984,225
Ensembl chr 1:254,786,091...254,978,967
G
Tnf
tumor necrosis factor
multiple interactions
ISO
AH 23848 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF]
CTD
PMID:9298541
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Tnfrsf1a
TNF receptor superfamily member 1A
multiple interactions
ISO
[6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to TNFRSF1A protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of TNFRSF1A protein
CTD
PMID:19407222
NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591
G
Abcb4
ATP binding cassette subfamily B member 4
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of ABCB4 mRNA
CTD
PMID:16940010
NCBI chr 4:26,106,895...26,164,440
Ensembl chr 4:25,151,953...25,209,202
G
Abcc3
ATP binding cassette subfamily C member 3
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of ABCC3 mRNA
CTD
PMID:17785943
NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595
G
Abl1
ABL proto-oncogene 1, non-receptor tyrosine kinase
increases methylation
ISO
alpha-hexachlorocyclohexane results in increased methylation of ABL1 promoter
CTD
PMID:35788154
NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065
G
Acaa2
acetyl-CoA acyltransferase 2
decreases expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of ACAA2 mRNA
CTD
PMID:16940010
NCBI chr18:70,620,310...70,648,417
Ensembl chr18:68,345,012...68,373,249
G
Acat2
acetyl-CoA acetyltransferase 2
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of ACAT2 mRNA
CTD
PMID:17785943
NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:47,695,788...47,752,821
G
Adap2
ArfGAP with dual PH domains 2
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of ADAP2 mRNA
CTD
PMID:16940010
NCBI chr10:65,635,891...65,665,019
Ensembl chr10:65,138,020...65,165,604
G
Adh1c
alcohol dehydrogenase 1C (class I), gamma polypeptide
decreases expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of ADH1 mRNA
CTD
PMID:16940010
NCBI chr 2:229,470,703...229,482,291
Ensembl chr 2:226,797,303...226,808,892
G
Aldh1a1
aldehyde dehydrogenase 1 family, member A1
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of ALDH1A1 mRNA
CTD
PMID:17785943
NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961
G
Apoc1
apolipoprotein C1
decreases expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of APOC1 mRNA
CTD
PMID:16940010
NCBI chr 1:88,475,018...88,479,052
Ensembl chr 1:79,346,136...79,350,375
G
App
amyloid beta precursor protein
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of APP mRNA
CTD
PMID:17785943
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
G
Ar
androgen receptor
multiple interactions
ISO
alpha-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; alpha-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; alpha-hexachlorocyclohexane inhibits the reaction [Metribolone results in increased activity of AR protein]
CTD
PMID:10696776 PMID:15084347 PMID:21962538 PMID:26022396
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925
G
Car2
carbonic anhydrase 2
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of CA2 mRNA
CTD
PMID:17785943
NCBI chr 2:88,462,883...88,478,012
Ensembl chr 2:86,741,626...86,756,818
G
Car3
carbonic anhydrase 3
decreases expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of CA3 mRNA
CTD
PMID:16940010 PMID:17785943
NCBI chr 2:88,491,666...88,501,299
Ensembl chr 2:86,770,420...86,784,280
G
Casp3
caspase 3
increases activity
ISO
alpha-hexachlorocyclohexane results in increased activity of CASP3 protein
CTD
PMID:19818741
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
G
Cat
catalase
multiple interactions increases activity
EXP
[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of CAT protein alpha-hexachlorocyclohexane results in increased activity of CAT protein
CTD
PMID:1708174 PMID:16046044
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
G
Cbx1
chromobox 1
decreases expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of CBX1 mRNA
CTD
PMID:16940010
NCBI chr10:82,266,746...82,286,431
Ensembl chr10:81,770,342...81,791,096
G
Cd36
CD36 molecule
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of CD36 mRNA
CTD
PMID:17785943
NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903
G
Cdc123
cell division cycle 123
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of CDC123 mRNA
CTD
PMID:16940010
NCBI chr17:77,368,376...77,412,659
Ensembl chr17:72,459,282...72,503,316
G
Cdk17
cyclin-dependent kinase 17
decreases expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of CDK17 mRNA
CTD
PMID:16940010
NCBI chr 7:29,570,982...29,677,613
Ensembl chr 7:27,683,890...27,764,910
G
Ces2h
carboxylesterase 2H
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of CES2 mRNA
CTD
PMID:17785943
NCBI chr19:49,884,164...49,898,764
Ensembl chr19:32,974,242...32,988,830
G
Chchd2
coiled-coil-helix-coiled-coil-helix domain containing 2
decreases expression increases expression affects expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of CHCHD2 mRNA alpha-hexachlorocyclohexane results in increased expression of CHCHD2 mRNA alpha-hexachlorocyclohexane affects the expression of CHCHD2 mRNA
CTD
PMID:16940010
NCBI chr12:32,464,847...32,470,871
Ensembl chr12:26,828,736...26,834,755
G
Cpn1
carboxypeptidase N subunit 1
affects expression increases expression decreases expression
EXP
alpha-hexachlorocyclohexane affects the expression of CPN1 mRNA alpha-hexachlorocyclohexane results in increased expression of CPN1 mRNA alpha-hexachlorocyclohexane results in decreased expression of CPN1 mRNA
CTD
PMID:16940010
NCBI chr 1:252,793,786...252,822,675
Ensembl chr 1:242,844,212...242,873,465
G
Ctsc
cathepsin C
decreases expression increases expression affects expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of CTSC mRNA alpha-hexachlorocyclohexane results in increased expression of CTSC mRNA alpha-hexachlorocyclohexane affects the expression of CTSC mRNA
CTD
PMID:16940010
NCBI chr 1:151,440,860...151,472,430
Ensembl chr 1:142,028,392...142,060,387
G
Cyb5a
cytochrome b5 type A
affects expression
EXP
alpha-hexachlorocyclohexane affects the expression of CYB5A mRNA
CTD
PMID:17785943
NCBI chr18:80,487,923...80,520,544
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
G
Cyb5r3
cytochrome b5 reductase 3
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of CYB5R3 mRNA
CTD
PMID:17785943
NCBI chr 7:116,186,729...116,204,290
Ensembl chr 7:114,306,685...114,324,298
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
EXP
[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP1A1 protein
CTD
PMID:11165752
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
G
Cyp2a1
cytochrome P450, family 2, subfamily a, polypeptide 1
multiple interactions
EXP
[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP2A1 protein
CTD
PMID:16246485
NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:82,231,611...82,244,887
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
multiple interactions increases activity
EXP
[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP2B1 protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2B1 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2B1 protein alpha-hexachlorocyclohexane results in increased activity of CYP2B1 protein
CTD
PMID:1372805 PMID:11165752 PMID:16246485
NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
G
Cyp2b15
cytochrome P450, family 2, subfamily b, polypeptide 15
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of CYP2B15 mRNA
CTD
PMID:17785943
NCBI chr 1:91,221,865...91,234,169
Ensembl chr 1:82,094,180...82,106,492
G
Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of CYP2B2 mRNA
CTD
PMID:16940010 PMID:17785943
NCBI chr 1:90,722,243...90,736,272
Ensembl chr 1:81,594,555...81,608,566
G
Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
multiple interactions
EXP
[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C11 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C11 protein
CTD
PMID:16246485
NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:236,762,842...236,799,066
G
Cyp2c12
cytochrome P450, family 2, subfamily c, polypeptide 12
decreases expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of CYP2C12 mRNA
CTD
PMID:17785943
NCBI chr 1:248,619,887...248,681,945
Ensembl chr 1:238,699,854...238,757,019
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
increases expression multiple interactions
EXP
alpha-hexachlorocyclohexane results in increased expression of CYP2C6 mRNA [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C6 protein
CTD
PMID:16246485 PMID:16940010
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
EXP
[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2E1 protein
CTD
PMID:16246485
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression multiple interactions
EXP
alpha-hexachlorocyclohexane results in increased expression of CYP3A2 mRNA [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of CYP3A2 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP3A2 protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 protein
CTD
PMID:11165752 PMID:16246485 PMID:16940010
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
G
Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of CYP3A23-3A1 mRNA
CTD
PMID:16940010
NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
G
Cyp4a8
cytochrome P450, family 4, subfamily a, polypeptide 8
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of CYP4A8 mRNA
CTD
PMID:17785943
NCBI chr 5:133,938,882...133,970,226
Ensembl chr 5:128,702,131...128,733,476
G
Cyp51
cytochrome P450, family 51
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of CYP51 mRNA
CTD
PMID:17785943
NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,036,865...30,055,410 Ensembl chr 6:30,036,865...30,055,410
G
Eci1
enoyl-CoA delta isomerase 1
decreases expression increases expression affects expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of ECI1 mRNA alpha-hexachlorocyclohexane results in increased expression of ECI1 mRNA alpha-hexachlorocyclohexane affects the expression of ECI1 mRNA
CTD
PMID:16940010
NCBI chr10:13,961,250...13,974,595
Ensembl chr10:13,456,563...13,470,061
G
Egf
epidermal growth factor
multiple interactions
EXP
[EGF protein co-treated with alpha-hexachlorocyclohexane] results in increased expression of MYC mRNA
CTD
PMID:12632255
NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064
G
Epcam
epithelial cell adhesion molecule
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of EPCAM mRNA
CTD
PMID:17785943
NCBI chr 6:12,633,715...12,649,678
Ensembl chr 6:6,878,237...6,896,127
G
Ephx1
epoxide hydrolase 1
increases expression increases activity
EXP
alpha-hexachlorocyclohexane results in increased expression of EPHX1 mRNA alpha-hexachlorocyclohexane results in increased activity of EPHX1 protein
CTD
PMID:1372805 PMID:16940010
NCBI chr13:95,246,079...95,275,852
Ensembl chr13:92,714,315...92,790,235
G
Esr1
estrogen receptor 1
multiple interactions increases activity
EXP ISO
alpha-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein] alpha-hexachlorocyclohexane results in increased activity of ESR1 protein
CTD
PMID:10580743 PMID:26022396
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
G
Esr2
estrogen receptor 2
increases activity
ISO
alpha-hexachlorocyclohexane results in increased activity of ESR2 protein
CTD
PMID:15064155
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919
G
Fev
FEV transcription factor, ETS family member
decreases expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of FEV mRNA
CTD
PMID:17785943
NCBI chr 9:83,887,844...83,891,718
Ensembl chr 9:76,439,172...76,443,065
G
Fgf1
fibroblast growth factor 1
decreases response to substance
EXP
alpha-hexachlorocyclohexane results in decreased susceptibility to FGF1 protein
CTD
PMID:1715812
NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,686,581...30,772,357
G
Fkbp3
FKBP prolyl isomerase 3
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of FKBP3 mRNA
CTD
PMID:17785943
NCBI chr 6:88,850,137...88,862,542
Ensembl chr 6:83,113,786...83,127,011
G
Fn1
fibronectin 1
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of FN1 mRNA
CTD
PMID:17785943
NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
alpha-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]
CTD
PMID:1380685
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
G
Ftl1
ferritin light chain 1
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of FTL1 mRNA
CTD
PMID:16940010
NCBI chr 1:105,072,858...105,074,705
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725 Ensembl chr 2:95,936,387...95,939,725
G
Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
decreases expression multiple interactions
EXP ISO
alpha-hexachlorocyclohexane results in decreased expression of GABRA1 mRNA alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
CTD
PMID:9316872 PMID:17785943
NCBI chr10:27,096,731...27,152,563
Ensembl chr10:26,595,160...26,650,864
G
Gabrb3
gamma-aminobutyric acid type A receptor subunit beta 3
multiple interactions
ISO
alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
CTD
PMID:9316872
NCBI chr 1:117,602,772...117,838,230
Ensembl chr 1:108,296,124...108,698,961
G
Gabrg2
gamma-aminobutyric acid type A receptor subunit gamma 2
multiple interactions
ISO
alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
CTD
PMID:9316872
NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,374,694...26,464,346
G
Gapdh
glyceraldehyde-3-phosphate dehydrogenase
affects expression decreases expression increases expression
EXP
alpha-hexachlorocyclohexane affects the expression of GAPDH mRNA alpha-hexachlorocyclohexane results in decreased expression of GAPDH mRNA alpha-hexachlorocyclohexane results in increased expression of GAPDH mRNA
CTD
PMID:16940010
NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235
G
Gpx2
glutathione peroxidase 2
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of GPX2 mRNA
CTD
PMID:17785943
NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:95,493,589...95,496,877
G
Gsr
glutathione-disulfide reductase
increases expression multiple interactions
EXP
alpha-hexachlorocyclohexane results in increased expression of GSR mRNA [Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of GSR protein
CTD
PMID:16046044 PMID:17785943
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
G
Gsta2
glutathione S-transferase alpha 2
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of GSTA2 mRNA
CTD
PMID:16940010 PMID:17785943
NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:79,184,322...79,196,798
G
Gsta5
glutathione S-transferase alpha 5
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of GSTA5 mRNA
CTD
PMID:17785943
NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:79,105,661...79,117,472
G
Gstk1
glutathione S-transferase kappa 1
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of GSTK1 mRNA
CTD
PMID:16940010
NCBI chr 4:72,085,532...72,089,934
Ensembl chr 4:71,118,896...71,123,292
G
Gstm4
glutathione S-transferase mu 4
decreases expression increases expression affects expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of GSTM4 mRNA alpha-hexachlorocyclohexane results in increased expression of GSTM4 mRNA alpha-hexachlorocyclohexane affects the expression of GSTM4 mRNA
CTD
PMID:16940010
NCBI chr 2:198,356,114...198,373,487
Ensembl chr 2:195,680,004...195,685,323
G
Gstp1
glutathione S-transferase pi 1
multiple interactions increases expression
EXP
[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of GSTP1 protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of GSTP1 protein alpha-hexachlorocyclohexane results in increased expression of GSTP1 mRNA
CTD
PMID:16246485 PMID:16940010
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
G
Hgf
hepatocyte growth factor
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of HGF protein
CTD
PMID:1370768
NCBI chr 4:19,628,902...19,700,467
Ensembl chr 4:18,677,101...18,745,409
G
Hspb1
heat shock protein family B (small) member 1
decreases expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of HSPB1 mRNA
CTD
PMID:17785943
NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743
G
Kcnj5
potassium inwardly-rectifying channel, subfamily J, member 5
affects expression
EXP
alpha-hexachlorocyclohexane affects the expression of KCNJ5 mRNA
CTD
PMID:17785943
NCBI chr 8:38,981,598...39,011,197
Ensembl chr 8:30,724,925...30,753,518
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Kit
KIT proto-oncogene receptor tyrosine kinase
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of KIT mRNA
CTD
PMID:16940010
NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,548,877...32,624,652
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Lpl
lipoprotein lipase
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of LPL mRNA
CTD
PMID:17785943
NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249
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Lrp2
LDL receptor related protein 2
decreases expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of LRP2 mRNA
CTD
PMID:16940010
NCBI chr 3:74,597,148...74,754,535
Ensembl chr 3:54,189,308...54,346,708
G
Luc7l2
LUC7-like 2 pre-mRNA splicing factor
affects expression
EXP
alpha-hexachlorocyclohexane affects the expression of LUC7L2 mRNA
CTD
PMID:17785943
NCBI chr 4:68,251,435...68,314,861
Ensembl chr 4:67,287,640...67,347,964
G
Mapk1
mitogen activated protein kinase 1
increases expression affects expression decreases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of MAPK1 mRNA alpha-hexachlorocyclohexane affects the expression of MAPK1 mRNA alpha-hexachlorocyclohexane results in decreased expression of MAPK1 mRNA
CTD
PMID:16940010
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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Mapk6
mitogen-activated protein kinase 6
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of MAPK6 mRNA
CTD
PMID:16940010
NCBI chr 8:85,027,141...85,050,236
Ensembl chr 8:76,146,690...76,169,720
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Me1
malic enzyme 1
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of ME1 mRNA
CTD
PMID:17785943
NCBI chr 8:96,429,057...96,540,244
Ensembl chr 8:87,549,043...87,660,304
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Meox2
mesenchyme homeobox 2
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of MEOX2 mRNA
CTD
PMID:17785943
NCBI chr 6:59,584,025...59,644,722
Ensembl chr 6:53,856,758...53,917,467
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Mt-co1
mitochondrially encoded cytochrome c oxidase I
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of COX1 mRNA
CTD
PMID:16940010
NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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Muc13
mucin 13, cell surface associated
decreases expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of MUC13 mRNA
CTD
PMID:17785943
NCBI chr11:80,462,350...80,489,773
Ensembl chr11:66,960,595...66,984,727
G
Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions
EXP
[EGF protein co-treated with alpha-hexachlorocyclohexane] results in increased expression of MYC mRNA
CTD
PMID:12632255
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
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Ncf1
neutrophil cytosolic factor 1
multiple interactions increases expression
ISO
Acetylcysteine inhibits the reaction [alpha-hexachlorocyclohexane results in increased expression of NCF1 mRNA]
CTD
PMID:28273962
NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646
G
Ncl
nucleolin
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of NCL mRNA
CTD
PMID:17785943
NCBI chr 9:94,447,559...94,456,083
Ensembl chr 9:86,998,019...87,008,136
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Nos3
nitric oxide synthase 3
increases expression multiple interactions
ISO
alpha-hexachlorocyclohexane results in increased expression of NOS3 mRNA Acetylcysteine inhibits the reaction [alpha-hexachlorocyclohexane results in increased expression of NOS3 mRNA]
CTD
PMID:28273962
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
G
Nqo1
NAD(P)H quinone dehydrogenase 1
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of NQO1 mRNA
CTD
PMID:16940010 PMID:17785943
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions increases activity
ISO
alpha-hexachlorocyclohexane binds to and results in increased activity of NR1I2 protein alpha-hexachlorocyclohexane results in increased activity of NR1I2 protein
CTD
PMID:21115097 PMID:25680588
NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
G
Ogg1
8-oxoguanine DNA glycosylase
multiple interactions
EXP
[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of OGG1 mRNA
CTD
PMID:16246485
NCBI chr 4:148,030,237...148,037,599
Ensembl chr 4:146,474,750...146,484,766
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Onecut1
one cut homeobox 1
affects expression
EXP
alpha-hexachlorocyclohexane affects the expression of ONECUT1 mRNA
CTD
PMID:17785943
NCBI chr 8:84,480,066...84,507,848
Ensembl chr 8:75,599,740...75,627,277
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Pcna
proliferating cell nuclear antigen
multiple interactions
EXP
[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of PCNA protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of PCNA protein
CTD
PMID:16246485
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
G
Pgr
progesterone receptor
multiple interactions
ISO
alpha-hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]
CTD
PMID:26022396
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
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Ppp2r2b
protein phosphatase 2, regulatory subunit B, beta
decreases expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of PPP2R2B mRNA
CTD
PMID:17785943
NCBI chr18:34,904,686...35,357,299
Ensembl chr18:34,653,721...35,081,025
G
Prss8
serine protease 8
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of PRSS8 mRNA
CTD
PMID:17785943
NCBI chr 1:191,966,701...191,971,271
Ensembl chr 1:182,536,229...182,540,815
G
Psat1
phosphoserine aminotransferase 1
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of PSAT1 mRNA
CTD
PMID:17785943
NCBI chr 1:222,623,553...222,646,187
Ensembl chr 1:213,196,709...213,218,682
G
Psmc3
proteasome 26S subunit, ATPase 3
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of PSMC3 mRNA
CTD
PMID:16940010
NCBI chr 3:97,487,643...97,493,025
Ensembl chr 3:77,031,825...77,043,358
G
Psme1
proteasome activator subunit 1
decreases expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of PSME1 mRNA
CTD
PMID:16940010
NCBI chr15:33,038,962...33,041,849
Ensembl chr15:29,068,729...29,071,890
G
Rab7a
RAB7A, member RAS oncogene family
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of RAB7 mRNA
CTD
PMID:17785943
NCBI chr 4:122,019,281...122,068,067
Ensembl chr 4:120,461,963...120,506,889
G
Rb1
RB transcriptional corepressor 1
affects expression increases expression decreases expression
EXP
alpha-hexachlorocyclohexane affects the expression of RB1 mRNA alpha-hexachlorocyclohexane results in increased expression of RB1 mRNA alpha-hexachlorocyclohexane results in decreased expression of RB1 mRNA
CTD
PMID:16940010
NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
G
Rnpep
arginyl aminopeptidase
decreases expression increases expression affects expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of RNPEP mRNA alpha-hexachlorocyclohexane results in increased expression of RNPEP mRNA alpha-hexachlorocyclohexane affects the expression of RNPEP mRNA
CTD
PMID:16940010
NCBI chr13:49,251,259...49,271,440
Ensembl chr13:46,699,463...46,717,998
G
Rplp0
ribosomal protein lateral stalk subunit P0
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of RPLP0 mRNA
CTD
PMID:16940010
NCBI chr12:46,715,121...46,718,390
Ensembl chr12:41,054,179...41,057,632
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Scd
stearoyl-CoA desaturase
decreases expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of SCD1 mRNA
CTD
PMID:17785943
NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
G
Slc16a1
solute carrier family 16 member 1
affects expression increases expression decreases expression
EXP
alpha-hexachlorocyclohexane affects the expression of SLC16A1 mRNA alpha-hexachlorocyclohexane results in increased expression of SLC16A1 mRNA alpha-hexachlorocyclohexane results in decreased expression of SLC16A1 mRNA
CTD
PMID:16940010
NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:192,124,289...192,144,611
G
Slc17a1
solute carrier family 17 member 1
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of SLC17A1 mRNA
CTD
PMID:17785943
NCBI chr17:41,647,332...41,683,078
Ensembl chr17:41,222,049...41,253,304
G
Smpx
small muscle protein, X-linked
decreases expression
EXP
alpha-hexachlorocyclohexane results in decreased expression of SMPX mRNA
CTD
PMID:17785943
NCBI chr X:41,049,354...41,107,323
Ensembl chr X:37,234,294...37,276,708
G
Snx4
sorting nexin 4
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of SNX4 mRNA
CTD
PMID:17785943
NCBI chr11:80,965,965...81,023,234
Ensembl chr11:67,460,870...67,518,174
G
Star
steroidogenic acute regulatory protein
multiple interactions
ISO
alpha-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR mRNA]; alpha-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR protein]
CTD
PMID:10993823
NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672
G
Suclg2
succinate-CoA ligase GDP-forming subunit beta
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of SUCLG2 mRNA
CTD
PMID:16940010
NCBI chr 4:129,623,833...129,893,937
Ensembl chr 4:128,067,033...128,337,170
G
Sult1b1
sulfotransferase family 1B member 1
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of SULT1B1 mRNA
CTD
PMID:16940010
NCBI chr14:20,771,917...20,784,665
Ensembl chr14:20,492,708...20,505,483
G
Tp53
tumor protein p53
increases expression affects expression decreases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of TP53 mRNA alpha-hexachlorocyclohexane affects the expression of TRP53 mRNA alpha-hexachlorocyclohexane results in decreased expression of TP53 mRNA
CTD
PMID:16940010
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
G
Ubc
ubiquitin C
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of UBC mRNA
CTD
PMID:16940010
NCBI chr12:36,899,673...36,905,275
Ensembl chr12:31,239,152...31,243,925
G
Ugt1a3
UDP glycosyltransferase 1 family, polypeptide A3
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of UGT1A5 mRNA
CTD
PMID:17785943
NCBI chr 9:96,228,134...96,256,264
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a6
UDP glucuronosyltransferase family 1 member A6
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of UGT1A6 mRNA
CTD
PMID:17785943
NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:88,713,184...88,808,465
G
Ugt1a7c
UDP glucuronosyltransferase 1 family, polypeptide A7C
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of UGT1A7 mRNA
CTD
PMID:16940010
NCBI chr 9:96,187,382...96,256,264
Ensembl chr 9:88,713,184...88,808,465
G
Ugt2a1
UDP glucuronosyltransferase family 2 member A1
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of UGT2A1 mRNA
CTD
PMID:16940010
NCBI chr14:20,797,262...20,825,111
Ensembl chr14:20,517,951...20,545,531
G
Ugt2b
UDP glycosyltransferase 2 family, polypeptide B
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of UGT2B mRNA
CTD
PMID:16940010
NCBI chr14:20,985,449...21,006,267
Ensembl chr14:20,630,250...20,651,776
G
Ugt2b1
UDP glucuronosyltransferase 2 family, polypeptide B1
increases expression
EXP
alpha-hexachlorocyclohexane results in increased expression of UGT2B1 mRNA
CTD
PMID:16940010 PMID:17785943
NCBI chr14:21,378,882...21,390,631
Ensembl chr14:21,024,006...21,035,986
G
Vip
vasoactive intestinal peptide
multiple interactions
EXP
alpha-hexachlorocyclohexane inhibits the reaction [VIP protein results in increased abundance of Cyclic AMP]
CTD
PMID:2467674
NCBI chr 1:44,470,232...44,478,561
Ensembl chr 1:42,065,120...42,073,216
G
Aatf
apoptosis antagonizing transcription factor
decreases expression
ISO
alpha phellandrene results in decreased expression of AATF mRNA
CTD
PMID:25075043
NCBI chr10:69,796,502...69,889,671
Ensembl chr10:69,299,037...69,392,201
G
Acp1
acid phosphatase 1
decreases expression
ISO
alpha phellandrene results in decreased expression of ACP1 mRNA
CTD
PMID:25075043
NCBI chr 6:53,233,937...53,249,576
Ensembl chr 6:47,506,380...47,522,021
G
Acss2
acyl-CoA synthetase short-chain family member 2
increases expression
ISO
alpha phellandrene results in increased expression of ACSS2 mRNA
CTD
PMID:25075043
NCBI chr 3:164,464,124...164,507,607
Ensembl chr 3:144,004,336...144,059,675
G
Adam18
ADAM metallopeptidase domain 18
decreases expression
ISO
alpha phellandrene results in decreased expression of ADAM18 mRNA
CTD
PMID:25075043
NCBI chr16:74,054,974...74,127,861
Ensembl chr16:67,352,416...67,425,248
G
Adam3a
ADAM metallopeptidase domain 3A
decreases expression
ISO
alpha phellandrene results in decreased expression of ADAM3 mRNA
CTD
PMID:25075043
NCBI chr16:74,002,566...74,052,579
Ensembl chr16:67,299,949...67,349,968
G
Afg2a
AFG2 AAA ATPase homolog A
decreases expression
ISO
alpha phellandrene results in decreased expression of AFG2A mRNA
CTD
PMID:25075043
NCBI chr 2:122,234,619...122,425,808
Ensembl chr 2:120,306,412...120,497,705
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Akt1
AKT serine/threonine kinase 1
decreases expression
ISO
alpha phellandrene results in decreased expression of AKT1 protein
CTD
PMID:25649747
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
G
Aldh1l2
aldehyde dehydrogenase 1 family, member L2
increases expression
ISO
alpha phellandrene results in increased expression of ALDH1L2 mRNA
CTD
PMID:25075043
NCBI chr 7:22,141,872...22,193,403
Ensembl chr 7:20,254,233...20,305,776
G
Aldoc
aldolase, fructose-bisphosphate C
increases expression
ISO
alpha phellandrene results in increased expression of ALDOC mRNA
CTD
PMID:25075043
NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,217,451...63,221,066
G
Ankrd49
ankyrin repeat domain 49
decreases expression
ISO
alpha phellandrene results in decreased expression of ANKRD49 mRNA
CTD
PMID:25075043
NCBI chr 8:19,908,968...19,913,656
Ensembl chr 8:11,627,518...11,632,207
G
Anxa1
annexin A1
increases expression
ISO
alpha phellandrene results in increased expression of ANXA1 mRNA
CTD
PMID:25075043
NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:217,861,175...217,877,343
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Anxa9
annexin A9
decreases expression
ISO
alpha phellandrene results in decreased expression of ANXA9 mRNA
CTD
PMID:25075043
NCBI chr 2:185,562,174...185,572,560
Ensembl chr 2:182,872,929...182,883,374
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Ap3m2
adaptor related protein complex 3 subunit mu 2
increases expression
ISO
alpha phellandrene results in increased expression of AP3M2 mRNA
CTD
PMID:25075043
NCBI chr16:75,908,459...75,937,915
Ensembl chr16:69,217,633...69,235,431
G
Arg2
arginase 2
increases expression
ISO
alpha phellandrene results in increased expression of ARG2 mRNA
CTD
PMID:25075043
NCBI chr 6:103,669,001...103,694,375
Ensembl chr 6:97,936,002...97,961,378
G
Arhgef12
Rho guanine nucleotide exchange factor 12
increases expression
ISO
alpha phellandrene results in increased expression of ARHGEF12 mRNA
CTD
PMID:25075043
NCBI chr 8:52,247,047...52,373,158
Ensembl chr 8:43,353,799...43,476,366
G
Arsk
arylsulfatase family, member K
decreases expression
ISO
alpha phellandrene results in decreased expression of ARSK mRNA
CTD
PMID:25075043
NCBI chr 2:7,306,181...7,363,311
Ensembl chr 2:5,574,322...5,631,467
G
Aspa
aspartoacylase
increases expression
ISO
alpha phellandrene results in increased expression of ASPA mRNA
CTD
PMID:25075043
NCBI chr10:58,390,204...58,443,790
Ensembl chr10:57,892,104...57,945,272
G
Atf3
activating transcription factor 3
increases expression
ISO
alpha phellandrene results in increased expression of ATF3 mRNA
CTD
PMID:25075043
NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631
G
Bcl2
BCL2, apoptosis regulator
increases phosphorylation
ISO
alpha phellandrene results in increased phosphorylation of BCL2 protein
CTD
PMID:25649747
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Becn1
beclin 1
increases phosphorylation
ISO
alpha phellandrene results in increased phosphorylation of BECN1 protein
CTD
PMID:25649747
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742
G
Bmf
Bcl2 modifying factor
increases expression
ISO
alpha phellandrene results in increased expression of BMF mRNA
CTD
PMID:25075043
NCBI chr 3:125,953,466...125,974,087
Ensembl chr 3:105,499,538...105,520,145
G
Bnip3
BCL2 interacting protein 3
increases expression
ISO
alpha phellandrene results in increased expression of BNIP3 mRNA
CTD
PMID:25075043
NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359
G
Bod1
biorientation of chromosomes in cell division 1
increases expression
ISO
alpha phellandrene results in increased expression of BOD1 mRNA
CTD
PMID:25075043
NCBI chr10:16,497,918...16,504,259
Ensembl chr10:15,993,454...15,999,787
G
Brca1
BRCA1, DNA repair associated
decreases expression
ISO
alpha phellandrene results in decreased expression of BRCA1 protein
CTD
PMID:24861204
NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,418,000...86,477,304
G
Btg2
BTG anti-proliferation factor 2
increases expression
ISO
alpha phellandrene results in increased expression of BTG2 mRNA
CTD
PMID:25075043
NCBI chr13:48,083,931...48,087,690
Ensembl chr13:45,531,925...45,535,628
G
Calm2
calmodulin 2
increases expression
ISO
alpha phellandrene results in increased expression of CALM2 mRNA
CTD
PMID:25075043
NCBI chr 6:12,845,170...12,857,830
Ensembl chr 6:7,091,567...7,104,287 Ensembl chr15:7,091,567...7,104,287
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Capns1
calpain, small subunit 1
increases expression
ISO
alpha phellandrene results in increased expression of CAPNS1 mRNA
CTD
PMID:25075043
NCBI chr 1:94,572,083...94,582,332
Ensembl chr 1:85,444,608...85,454,795
G
Caprin2
caprin family member 2
increases expression
ISO
alpha phellandrene results in increased expression of CAPRIN2 mRNA
CTD
PMID:25075043
NCBI chr 4:183,537,935...183,592,162
Ensembl chr 4:181,806,575...181,860,830
G
Card6
caspase recruitment domain family, member 6
increases expression
ISO
alpha phellandrene results in increased expression of CARD6 mRNA
CTD
PMID:25075043
NCBI chr 2:55,921,832...55,934,388
Ensembl chr 2:54,195,739...54,206,846
G
Carhsp1
calcium regulated heat stable protein 1
increases expression
ISO
alpha phellandrene results in increased expression of CARHSP1 mRNA
CTD
PMID:25075043
NCBI chr10:7,453,602...7,467,218
Ensembl chr10:6,946,959...7,020,019
G
Ccl5
C-C motif chemokine ligand 5
increases expression
ISO
alpha phellandrene results in increased expression of CCL5 mRNA
CTD
PMID:25075043
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
G
Ccng2
cyclin G2
increases expression
ISO
alpha phellandrene results in increased expression of CCNG2 mRNA
CTD
PMID:25075043
NCBI chr14:15,088,694...15,097,190
Ensembl chr14:14,804,322...14,812,830
G
Ccrl2
C-C motif chemokine receptor like 2
increases expression
ISO
alpha phellandrene results in increased expression of CCRL2 mRNA
CTD
PMID:25075043
NCBI chr 8:119,912,671...119,915,313
Ensembl chr 8:111,034,279...111,036,664
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Cd59b
CD59b molecule
decreases expression
ISO
alpha phellandrene results in decreased expression of CD59A mRNA
CTD
PMID:25075043
NCBI chr 3:110,914,008...110,932,489
Ensembl chr 3:90,459,162...90,478,847
G
Cdcp2
CUB domain containing protein 2
increases expression
ISO
alpha phellandrene results in increased expression of CDCP2 mRNA
CTD
PMID:25075043
NCBI chr 5:127,106,380...127,124,243
Ensembl chr 5:121,877,581...121,894,203
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
alpha phellandrene results in increased expression of CDKN1A mRNA
CTD
PMID:25075043
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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Cdkn2d
cyclin dependent kinase inhibitor 2D
increases expression
ISO
alpha phellandrene results in increased expression of CDKN2D mRNA
CTD
PMID:25075043
NCBI chr 8:28,108,036...28,110,809
Ensembl chr 8:19,831,866...19,834,674
G
Cflar
CASP8 and FADD-like apoptosis regulator
increases expression
ISO
alpha phellandrene results in increased expression of CFLAR mRNA
CTD
PMID:25075043
NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034
G
Clec12a
C-type lectin domain family 12, member A
decreases expression
ISO
alpha phellandrene results in decreased expression of CLEC12A mRNA
CTD
PMID:25075043
NCBI chr 4:164,484,162...164,502,793
Ensembl chr 4:162,798,125...162,816,753
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Clec4d
C-type lectin domain family 4, member D
decreases expression
ISO
alpha phellandrene results in decreased expression of CLEC4D mRNA
CTD
PMID:25075043
NCBI chr 4:158,275,287...158,286,978
Ensembl chr 4:156,589,792...156,598,848
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Clec6a-ps1
C-type lectin domain family 6, member A, pseudogene 1
decreases expression
ISO
alpha phellandrene results in decreased expression of CLEC4N mRNA
CTD
PMID:25075043
NCBI chr 4:158,225,100...158,244,722
Ensembl chr 4:156,539,408...156,558,605 Ensembl chr 4:156,539,408...156,558,605
G
Cluh
clustered mitochondria homolog
decreases expression
ISO
alpha phellandrene results in decreased expression of CLUH mRNA
CTD
PMID:25075043
NCBI chr10:60,008,052...60,029,742
Ensembl chr10:59,509,726...59,531,345
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Cmpk2
cytidine/uridine monophosphate kinase 2
increases expression
ISO
alpha phellandrene results in increased expression of CMPK2 mRNA
CTD
PMID:25075043
NCBI chr 6:48,802,150...48,813,652
Ensembl chr 6:43,073,796...43,085,183
G
Cr1l
complement C3b/C4b receptor 1 like
decreases expression
ISO
alpha phellandrene results in decreased expression of CR1L mRNA
CTD
PMID:25075043
NCBI chr13:109,138,132...109,189,068
Ensembl chr13:106,574,858...106,660,445
G
Crisp1
cysteine-rich secretory protein 1
decreases expression
ISO
alpha phellandrene results in decreased expression of CRISP1 mRNA
CTD
PMID:25075043
NCBI chr 9:28,238,326...28,265,344
Ensembl chr 9:20,741,777...20,768,796
G
Cst7
cystatin F
decreases expression
ISO
alpha phellandrene results in decreased expression of CST7 mRNA
CTD
PMID:25075043
NCBI chr 3:159,857,221...159,865,987
Ensembl chr 3:139,396,850...139,405,557
G
Csta
cystatin A
increases expression
ISO
alpha phellandrene results in increased expression of STFA1 mRNA
CTD
PMID:25075043
NCBI chr11:78,125,813...78,136,818
Ensembl chr11:64,620,483...64,631,488
G
Ctsg
cathepsin G
decreases expression
ISO
alpha phellandrene results in decreased expression of CTSG mRNA
CTD
PMID:25075043
NCBI chr15:33,901,230...33,907,596
Ensembl chr15:29,931,003...29,937,353
G
Cxcl10
C-X-C motif chemokine ligand 10
increases expression
ISO
alpha phellandrene results in increased expression of CXCL10 mRNA
CTD
PMID:25075043
NCBI chr14:15,989,066...15,991,263
Ensembl chr14:15,704,758...15,706,975
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Cyb561d2
cytochrome b561 family, member D2
decreases expression
ISO
alpha phellandrene results in decreased expression of CYB561D2 mRNA
CTD
PMID:25075043
NCBI chr 8:117,091,844...117,094,434
Ensembl chr 8:108,213,205...108,215,759
G
Cyfip2
cytoplasmic FMR1 interacting protein 2
increases expression
ISO
alpha phellandrene results in increased expression of CYFIP2 mRNA
CTD
PMID:25075043
NCBI chr10:31,122,653...31,242,440
Ensembl chr10:30,621,318...30,741,113
G
Cyp51
cytochrome P450, family 51
decreases expression
ISO
alpha phellandrene results in decreased expression of CYP51 mRNA
CTD
PMID:25075043
NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,036,865...30,055,410 Ensembl chr 6:30,036,865...30,055,410
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Dbx1
developing brain homeobox 1
increases expression
ISO
alpha phellandrene results in increased expression of DBX1 mRNA
CTD
PMID:25075043
NCBI chr 1:108,484,846...108,490,381
Ensembl chr 1:99,349,608...99,354,038
G
Dctd
dCMP deaminase
decreases expression
ISO
alpha phellandrene results in decreased expression of DCTD mRNA
CTD
PMID:25075043
NCBI chr16:50,799,699...50,831,398
Ensembl chr16:44,055,128...44,098,446
G
Ddit4
DNA-damage-inducible transcript 4
increases expression
ISO
alpha phellandrene results in increased expression of DDIT4 mRNA
CTD
PMID:25075043
NCBI chr20:28,434,938...28,437,037
Ensembl chr20:27,891,998...27,894,105
G
Ddx31
DEAD-box helicase 31
decreases expression
ISO
alpha phellandrene results in decreased expression of DDX31 mRNA
CTD
PMID:25075043
NCBI chr 3:32,570,725...32,635,446
Ensembl chr 3:12,172,836...12,238,873
G
Ddx60
DEXD/H-box helicase 60
increases expression
ISO
alpha phellandrene results in increased expression of DDX60 mRNA
CTD
PMID:25075043
NCBI chr16:33,087,940...33,208,843
Ensembl chr16:28,076,999...28,179,526
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Dffb
DNA fragmentation factor subunit beta
increases expression
ISO
alpha phellandrene results in increased expression of DFFB mRNA
CTD
PMID:25075043
NCBI chr 5:169,804,873...169,817,157
Ensembl chr 5:164,522,463...164,534,628
G
Dgka
diacylglycerol kinase, alpha
increases expression
ISO
alpha phellandrene results in increased expression of DGKA mRNA
CTD
PMID:25075043
NCBI chr 7:1,733,247...1,761,181
Ensembl chr 7:1,148,735...1,175,110
G
Dhrs1
dehydrogenase/reductase 1
increases expression
ISO
alpha phellandrene results in increased expression of DHRS1 mRNA
CTD
PMID:25075043
NCBI chr15:33,206,449...33,213,776
Ensembl chr15:29,236,522...29,243,838
G
Dhx33
DEAH-box helicase 33
decreases expression
ISO
alpha phellandrene results in decreased expression of DHX33 mRNA
CTD
PMID:25075043
NCBI chr10:56,206,680...56,223,189
Ensembl chr10:55,705,756...55,724,567
G
Dhx58
DEXH-box helicase 58
increases expression
ISO
alpha phellandrene results in increased expression of DHX58 mRNA
CTD
PMID:25075043
NCBI chr10:86,120,677...86,132,095
Ensembl chr10:85,620,357...85,631,525
G
Dkc1
dyskerin pseudouridine synthase 1
decreases expression
ISO
alpha phellandrene results in decreased expression of DKC1 mRNA
CTD
PMID:25075043
NCBI chr X:157,751,651...157,757,796
G
Dusp1
dual specificity phosphatase 1
increases expression
ISO
alpha phellandrene results in increased expression of DUSP1 mRNA
CTD
PMID:25075043
NCBI chr10:17,184,853...17,187,646
G
Dusp6
dual specificity phosphatase 6
increases expression
ISO
alpha phellandrene results in increased expression of DUSP6 mRNA
CTD
PMID:25075043
NCBI chr 7:35,979,502...35,983,834
Ensembl chr 7:34,092,943...34,097,185
G
Dynlt3
dynein light chain Tctex-type 3
increases expression
ISO
alpha phellandrene results in increased expression of DYNLT3 mRNA
CTD
PMID:25075043
NCBI chr X:16,000,425...16,009,632
Ensembl chr X:13,327,892...13,337,139
G
Egln3
egl-9 family hypoxia-inducible factor 3
increases expression
ISO
alpha phellandrene results in increased expression of EGLN3 mRNA
CTD
PMID:25075043
NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:71,650,297...71,675,766
G
Egr1
early growth response 1
increases expression
ISO
alpha phellandrene results in increased expression of EGR1 mRNA
CTD
PMID:25075043
NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766
G
Eif5
eukaryotic translation initiation factor 5
decreases expression
ISO
alpha phellandrene results in decreased expression of EIF5 mRNA
CTD
PMID:25075043
NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:130,589,143...130,597,656
G
Elac2
elaC ribonuclease Z 2
decreases expression
ISO
alpha phellandrene results in decreased expression of ELAC2 mRNA
CTD
PMID:25075043
NCBI chr10:50,131,449...50,154,755
Ensembl chr10:49,632,378...49,655,614
G
Elovl1
ELOVL fatty acid elongase 1
decreases expression
ISO
alpha phellandrene results in decreased expression of ELOVL1 mRNA
CTD
PMID:25075043
NCBI chr 5:137,246,781...137,251,351
Ensembl chr 5:131,961,322...131,965,958
G
Elovl7
ELOVL fatty acid elongase 7
increases expression
ISO
alpha phellandrene results in increased expression of ELOVL7 mRNA
CTD
PMID:25075043
NCBI chr 2:41,522,695...41,592,021
Ensembl chr 2:39,789,250...39,856,845
G
Eno2
enolase 2
increases expression
ISO
alpha phellandrene results in increased expression of ENO2 mRNA
CTD
PMID:25075043
NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:157,572,088...157,580,980
G
Fbxo44
F-box protein 44
increases expression
ISO
alpha phellandrene results in increased expression of FBXO44 mRNA
CTD
PMID:25075043
NCBI chr 5:163,866,517...163,875,928
Ensembl chr 5:158,583,366...158,592,363
G
Fggy
FGGY carbohydrate kinase domain containing
increases expression
ISO
alpha phellandrene results in increased expression of FGGY mRNA
CTD
PMID:25075043
NCBI chr 5:115,514,573...115,901,713
Ensembl chr 5:110,398,863...110,786,017
G
Flvcr1
FLVCR choline and heme transporter 1
decreases expression
ISO
alpha phellandrene results in decreased expression of FLVCR1 mRNA
CTD
PMID:25075043
NCBI chr13:105,117,402...105,139,780
Ensembl chr13:102,586,257...102,608,661
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
alpha phellandrene results in increased expression of FOS mRNA
CTD
PMID:25075043
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
G
Foxo1
forkhead box O1
increases expression
ISO
alpha phellandrene results in increased expression of FOXO1 mRNA
CTD
PMID:25075043
NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
G
Fpr1
formyl peptide receptor 1
decreases expression
ISO
alpha phellandrene results in decreased expression of FPR1 mRNA
CTD
PMID:25075043
NCBI chr 1:67,417,991...67,429,813
Ensembl chr 1:58,747,246...58,756,559
G
Fth1
ferritin heavy chain 1
increases expression
ISO
alpha phellandrene results in increased expression of FTH1 mRNA
CTD
PMID:25075043
NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424
G
Ftl1
ferritin light chain 1
increases expression
ISO
alpha phellandrene results in increased expression of FTL1 mRNA; alpha phellandrene results in increased expression of FTL2-PS mRNA
CTD
PMID:25075043
NCBI chr 1:105,072,858...105,074,705
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725 Ensembl chr 2:95,936,387...95,939,725
G
Ftsj3
FtsJ RNA 2'-O-methyltransferase 3
decreases expression
ISO
alpha phellandrene results in decreased expression of FTSJ3 mRNA
CTD
PMID:25075043
NCBI chr10:91,680,735...91,687,475
Ensembl chr10:91,180,696...91,187,397
G
Fxn
frataxin
decreases expression
ISO
alpha phellandrene results in decreased expression of FXN mRNA
CTD
PMID:25075043
NCBI chr 1:231,300,457...231,323,989
Ensembl chr 1:221,872,420...221,897,540
G
Gabarap
GABA type A receptor-associated protein
increases expression
ISO
alpha phellandrene results in increased expression of GABARAP mRNA
CTD
PMID:25075043
NCBI chr10:55,213,465...55,216,787
Ensembl chr10:54,714,198...54,717,765
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
ISO
alpha phellandrene results in increased expression of GADD45A mRNA
CTD
PMID:25075043
NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115
G
Gas5
growth arrest specific 5
decreases expression
ISO
alpha phellandrene results in decreased expression of GAS5 mRNA
CTD
PMID:25075043
NCBI chr13:75,836,963...75,840,284
G
Gbp6
guanylate binding protein family member 6
increases expression
ISO
alpha phellandrene results in increased expression of GBP6 mRNA
CTD
PMID:25075043
NCBI chr14:5,034,999...5,062,023
Ensembl chr14:4,730,453...4,839,062 Ensembl chr14:4,730,453...4,839,062
G
Gnas
GNAS complex locus
increases expression
ISO
alpha phellandrene results in increased expression of GNAS mRNA
CTD
PMID:25075043
NCBI chr 3:183,489,648...183,554,570
Ensembl chr 3:163,071,417...163,127,262 Ensembl chr 3:163,071,417...163,127,262
G
Gnl3
G protein nucleolar 3
decreases expression
ISO
alpha phellandrene results in decreased expression of GNL3 mRNA
CTD
PMID:25075043
NCBI chr16:6,213,844...6,220,029
Ensembl chr16:6,207,402...6,213,392
G
Gpr84
G protein-coupled receptor 84
decreases expression
ISO
alpha phellandrene results in decreased expression of GPR84 mRNA
CTD
PMID:25075043
NCBI chr 7:136,322,374...136,324,648
Ensembl chr 7:134,443,936...134,446,178
G
Greb1l
GREB1 like retinoic acid receptor coactivator
increases expression
ISO
alpha phellandrene results in increased expression of GREB1L mRNA
CTD
PMID:25075043
NCBI chr18:1,665,468...1,902,291
Ensembl chr18:1,392,725...1,628,067
G
Grina
glutamate ionotropic receptor NMDA type subunit associated protein 1
increases expression
ISO
alpha phellandrene results in increased expression of GRINA mRNA
CTD
PMID:25075043
NCBI chr 7:109,842,870...109,846,048
Ensembl chr 7:107,962,207...107,965,366
G
Gtdc1
glycosyltransferase-like domain containing 1
increases expression
ISO
alpha phellandrene results in increased expression of GTDC1 mRNA
CTD
PMID:25075043
NCBI chr 3:49,176,110...49,571,594
Ensembl chr 3:28,766,645...29,162,271
G
Gys1
glycogen synthase 1
increases expression
ISO
alpha phellandrene results in increased expression of GYS1 mRNA
CTD
PMID:25075043
NCBI chr 1:105,051,916...105,071,763
Ensembl chr 1:95,915,443...95,935,292
G
Gzmf
granzyme F
decreases expression
ISO
alpha phellandrene results in decreased expression of GZME mRNA
CTD
PMID:25075043
NCBI chr15:33,975,543...33,997,505
Ensembl chr15:30,007,267...30,018,649
G
H1f0
H1.0 linker histone
increases expression
ISO
alpha phellandrene results in increased expression of H1F0 mRNA
CTD
PMID:25075043
NCBI chr 7:112,473,280...112,475,140
Ensembl chr 7:110,592,208...110,594,694
G
H1f2
H1.2 linker histone, cluster member
increases expression
ISO
alpha phellandrene results in increased expression of H1F2 mRNA
CTD
PMID:25075043
NCBI chr17:41,818,962...41,820,453
Ensembl chr17:41,388,477...41,392,635
G
H2bc18
H2B clustered histone 18
increases expression
ISO
alpha phellandrene results in increased expression of H2BC18 mRNA
CTD
PMID:25075043
NCBI chr 2:186,527,197...186,531,634
Ensembl chr 2:183,838,334...183,841,529
G
Hcar2
hydroxycarboxylic acid receptor 2
increases expression
ISO
alpha phellandrene results in increased expression of HCAR2 mRNA
CTD
PMID:25075043
NCBI chr12:38,387,163...38,389,149
Ensembl chr12:32,726,184...32,728,504
G
Heatr1
HEAT repeat containing 1
decreases expression
ISO
alpha phellandrene results in decreased expression of HEATR1 mRNA
CTD
PMID:25075043
NCBI chr17:62,745,008...62,785,609
Ensembl chr17:58,051,700...58,093,948
G
Helz2
helicase with zinc finger 2
increases expression
ISO
alpha phellandrene results in increased expression of HELZ2 mRNA
CTD
PMID:25075043
NCBI chr 3:188,716,370...188,730,776
Ensembl chr 3:168,338,813...168,353,159
G
Hgh1
HGH1 homolog
decreases expression
ISO
alpha phellandrene results in decreased expression of BRP16 mRNA
CTD
PMID:25075043
NCBI chr 7:109,972,079...109,975,398
Ensembl chr 7:108,091,951...108,094,737
G
Hilpda
hypoxia inducible lipid droplet-associated
increases expression
ISO
alpha phellandrene results in increased expression of HILPDA mRNA
CTD
PMID:25075043
NCBI chr 4:58,836,463...58,839,423
Ensembl chr 4:57,871,110...57,874,557
G
Hivep3
HIVEP zinc finger 3
increases expression
ISO
alpha phellandrene results in increased expression of HIVEP3 mRNA
CTD
PMID:25075043
NCBI chr 5:138,610,592...139,013,058
Ensembl chr 5:133,658,052...133,727,795
G
Hspa2
heat shock protein family A (Hsp70) member 2
increases expression
ISO
alpha phellandrene results in increased expression of HSPA2 mRNA
CTD
PMID:25075043
NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:95,128,350...95,131,287
G
Hspa5
heat shock protein family A (Hsp70) member 5
decreases expression
ISO
alpha phellandrene results in decreased expression of HSPA5 mRNA
CTD
PMID:25075043
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
G
Hspa8
heat shock protein family A (Hsp70) member 8
decreases expression
ISO
alpha phellandrene results in decreased expression of HSPA8 mRNA
CTD
PMID:25075043
NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259
G
Id2
inhibitor of DNA binding 2
increases expression
ISO
alpha phellandrene results in increased expression of ID2 mRNA
CTD
PMID:25075043
NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:41,728,946...41,744,400
G
Idi1
isopentenyl-diphosphate delta isomerase 1
decreases expression
ISO
alpha phellandrene results in decreased expression of IDI1 mRNA
CTD
PMID:25075043
NCBI chr17:66,539,761...66,547,524
Ensembl chr17:61,629,594...61,637,357
G
Ifih1
interferon induced with helicase C domain 1
increases expression
ISO
alpha phellandrene results in increased expression of IFIH1 mRNA
CTD
PMID:25075043
NCBI chr 3:67,635,924...67,683,968
Ensembl chr 3:47,227,364...47,275,456
G
Ifnl3
interferon, lambda 3
increases expression
ISO
alpha phellandrene results in increased expression of IFNL3 mRNA
CTD
PMID:25075043
NCBI chr 1:92,941,988...92,943,628
Ensembl chr 1:83,814,564...83,816,096
G
Il2ra
interleukin 2 receptor subunit alpha
decreases expression
ISO
alpha phellandrene results in decreased expression of IL2RA mRNA
CTD
PMID:25075043
NCBI chr17:71,759,802...71,808,475
Ensembl chr17:66,849,974...66,898,697
G
Il36g
interleukin 36, gamma
decreases expression
ISO
alpha phellandrene results in decreased expression of IL36G mRNA
CTD
PMID:25075043
NCBI chr 3:27,346,675...27,352,839
Ensembl chr 3:6,948,297...6,954,480
G
Irf5
interferon regulatory factor 5
increases expression
ISO
alpha phellandrene results in increased expression of IRF5 mRNA
CTD
PMID:25075043
NCBI chr 4:59,092,914...59,104,596
Ensembl chr 4:58,127,640...58,139,267
G
Irf7
interferon regulatory factor 7
increases expression
ISO
alpha phellandrene results in increased expression of IRF7 mRNA
CTD
PMID:25075043
NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:196,367,361...196,370,832
G
Irgm
immunity-related GTPase M
increases expression
ISO
alpha phellandrene results in increased expression of IRGM2 mRNA
CTD
PMID:25075043
NCBI chr10:33,734,640...33,742,720
Ensembl chr10:33,233,455...33,241,578
G
Itgal
integrin subunit alpha L
increases expression
ISO
alpha phellandrene results in increased expression of ITGAL mRNA
CTD
PMID:25075043
NCBI chr 1:191,348,424...191,386,228
Ensembl chr 1:181,918,183...181,955,732
G
Jagn1
jagunal homolog 1
decreases expression
ISO
alpha phellandrene results in decreased expression of JAGN1 mRNA
CTD
PMID:25075043
NCBI chr 4:148,147,213...148,151,915
Ensembl chr 4:146,591,510...146,596,288
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
alpha phellandrene results in increased expression of JUN mRNA
CTD
PMID:25075043
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
G
Kank2
KN motif and ankyrin repeat domains 2
decreases expression
ISO
alpha phellandrene results in decreased expression of KANK2 mRNA
CTD
PMID:25075043
NCBI chr 8:28,587,770...28,617,212
Ensembl chr 8:20,311,676...20,340,900
G
Kdm7a
lysine demethylase 7A
increases expression
ISO
alpha phellandrene results in increased expression of KDM7A mRNA
CTD
PMID:25075043
NCBI chr 4:68,866,263...68,992,979
Ensembl chr 4:67,904,307...67,966,998
G
Klhl24
kelch-like family member 24
increases expression
ISO
alpha phellandrene results in increased expression of KLHL24 mRNA
CTD
PMID:25075043
NCBI chr11:94,348,024...94,382,085
Ensembl chr11:80,846,755...80,877,636
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Lima1
LIM domain and actin binding 1
increases expression
ISO
alpha phellandrene results in increased expression of LIMA1 mRNA
CTD
PMID:25075043
NCBI chr 7:132,780,556...132,880,343
Ensembl chr 7:130,901,717...131,001,473
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Llgl2
LLGL scribble cell polarity complex component 2
decreases expression
ISO
alpha phellandrene results in decreased expression of LLGL2 mRNA
CTD
PMID:25075043
NCBI chr10:101,549,911...101,585,466
Ensembl chr10:101,051,408...101,086,525
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LOC120098677
small nucleolar RNA MBII-202
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORD68 mRNA
CTD
PMID:25075043
NCBI chr19:68,063,150...68,063,232
Ensembl chr19:51,154,626...51,154,708
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Lpp
LIM domain containing preferred translocation partner in lipoma
increases expression
ISO
alpha phellandrene results in increased expression of LPP mRNA
CTD
PMID:25075043
NCBI chr11:89,292,060...89,933,973
Ensembl chr11:75,797,078...76,422,597
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Ltn1
listerin E3 ubiquitin protein ligase 1
decreases expression
ISO
alpha phellandrene results in decreased expression of LTN1 mRNA
CTD
PMID:25075043
NCBI chr11:40,090,169...40,147,159
Ensembl chr11:26,603,903...26,660,886
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Ly6h
lymphocyte antigen 6 family member H
decreases expression
ISO
alpha phellandrene results in decreased expression of LY6C1 mRNA; alpha phellandrene results in decreased expression of LY6C2 mRNA
CTD
PMID:25075043
NCBI chr 7:109,139,527...109,142,108
Ensembl chr 7:107,258,779...107,261,454
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Map2k6
mitogen-activated protein kinase kinase 6
increases expression
ISO
alpha phellandrene results in increased expression of MAP2K6 mRNA
CTD
PMID:25075043
NCBI chr10:95,872,747...95,987,747
Ensembl chr10:95,373,204...95,488,293
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Mat2a
methionine adenosyltransferase 2A
decreases expression
ISO
alpha phellandrene results in decreased expression of MAT2A mRNA
CTD
PMID:25075043
NCBI chr 4:106,048,043...106,053,612
Ensembl chr 4:104,488,466...104,495,493
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Mcemp1
mast cell-expressed membrane protein 1
increases expression
ISO
alpha phellandrene results in increased expression of MCEMP1 mRNA
CTD
PMID:25075043
NCBI chr12:6,519,709...6,523,880
Ensembl chr12:1,718,730...1,725,986
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Mdc1
mediator of DNA damage checkpoint 1
increases expression
ISO
alpha phellandrene results in increased expression of MDC1 protein
CTD
PMID:24861204
NCBI chr20:2,898,496...2,914,960
Ensembl chr20:2,895,505...2,910,240
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Mdn1
midasin AAA ATPase 1
decreases expression
ISO
alpha phellandrene results in decreased expression of MDN1 mRNA
CTD
PMID:25075043
NCBI chr 5:51,851,785...51,982,688
Ensembl chr 5:47,055,447...47,186,332
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Med29
mediator complex subunit 29
decreases expression
ISO
alpha phellandrene results in decreased expression of MED29 mRNA
CTD
PMID:25075043
NCBI chr 1:92,805,505...92,810,908
Ensembl chr 1:83,677,961...83,683,365
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Med31
mediator complex subunit 31
increases expression
ISO
alpha phellandrene results in increased expression of MED31 mRNA
CTD
PMID:25075043
NCBI chr10:57,335,507...57,338,889
Ensembl chr10:56,836,944...56,840,326
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Mgarp
mitochondria-localized glutamic acid-rich protein
increases expression
ISO
alpha phellandrene results in increased expression of MGARP mRNA
CTD
PMID:25075043
NCBI chr 2:137,582,152...137,590,294
Ensembl chr 2:135,431,283...135,439,612
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Mgat2
alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
decreases expression
ISO
alpha phellandrene results in decreased expression of MGAT2 mRNA
CTD
PMID:25075043
NCBI chr 6:93,392,416...93,394,905
Ensembl chr 6:87,656,349...87,658,177
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Mgmt
O-6-methylguanine-DNA methyltransferase
decreases expression
ISO
alpha phellandrene results in decreased expression of MGMT protein
CTD
PMID:24861204
NCBI chr 1:201,140,832...201,367,481
Ensembl chr 1:191,710,930...191,937,756
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Mindy2
MINDY lysine 48 deubiquitinase 2
increases expression
ISO
alpha phellandrene results in increased expression of MINDY2 mRNA
CTD
PMID:25075043
NCBI chr 8:80,149,127...80,210,011
Ensembl chr 8:71,256,447...71,328,453
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Mir375
microRNA 375
increases expression
ISO
alpha phellandrene results in increased expression of MIR375 mRNA
CTD
PMID:25075043
NCBI chr 9:83,906,582...83,906,656
Ensembl chr 9:76,457,911...76,457,985
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Mr1
major histocompatibility complex, class I-related
increases expression
ISO
alpha phellandrene results in increased expression of MR1 mRNA
CTD
PMID:25075043
NCBI chr13:69,850,420...69,868,302
Ensembl chr13:67,299,585...67,317,970
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Mrpl20
mitochondrial ribosomal protein L20
decreases expression
ISO
alpha phellandrene results in decreased expression of MRPL20 mRNA
CTD
PMID:25075043
NCBI chr 5:171,690,664...171,695,728
Ensembl chr 5:166,408,962...166,413,492
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Mrpl45
mitochondrial ribosomal protein L45
increases expression
ISO
alpha phellandrene results in increased expression of MRPL45 mRNA
CTD
PMID:25075043
NCBI chr10:82,805,039...82,816,862
Ensembl chr10:82,308,427...82,320,474
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Mrto4
MRT4 homolog, ribosome maturation factor
decreases expression
ISO
alpha phellandrene results in decreased expression of MRTO4 mRNA
CTD
PMID:25075043
NCBI chr 5:156,884,985...156,891,738
Ensembl chr 5:151,601,780...151,608,287
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Ms4a3
membrane spanning 4-domains A3
decreases expression
ISO
alpha phellandrene results in decreased expression of MS4A3 mRNA
CTD
PMID:25075043
NCBI chr 1:217,887,105...217,904,921
Ensembl chr 1:208,462,301...208,480,101
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Mtor
mechanistic target of rapamycin kinase
decreases expression
ISO
alpha phellandrene results in decreased expression of MTOR protein
CTD
PMID:25649747
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
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Mtx3
metaxin 3
decreases expression
ISO
alpha phellandrene results in decreased expression of MTX3 mRNA
CTD
PMID:25075043
NCBI chr 2:25,800,530...25,814,755
Ensembl chr 2:24,066,365...24,079,670
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Muc13
mucin 13, cell surface associated
decreases expression
ISO
alpha phellandrene results in decreased expression of MUC13 mRNA
CTD
PMID:25075043
NCBI chr11:80,462,350...80,489,773
Ensembl chr11:66,960,595...66,984,727
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Mx2
MX dynamin like GTPase 2
increases expression
ISO
alpha phellandrene results in increased expression of MX2 mRNA
CTD
PMID:25075043
NCBI chr11:50,375,101...50,399,373
Ensembl chr11:36,906,111...36,930,342
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Mxd1
max dimerization protein 1
increases expression
ISO
alpha phellandrene results in increased expression of MXD1 mRNA
CTD
PMID:25075043
NCBI chr 4:120,654,731...120,678,972
Ensembl chr 4:119,097,353...119,117,751
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Myadm
myeloid-associated differentiation marker
increases expression
ISO
alpha phellandrene results in increased expression of MYADM mRNA
CTD
PMID:25075043
NCBI chr 1:74,779,616...74,796,752
Ensembl chr 1:65,864,173...65,874,035
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Mybbp1a
MYB binding protein 1a
decreases expression
ISO
alpha phellandrene results in decreased expression of MYBBP1A mRNA
CTD
PMID:25075043
NCBI chr10:57,555,458...57,565,819
Ensembl chr10:57,056,874...57,067,255
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Myo9a
myosin IXA
increases expression
ISO
alpha phellandrene results in increased expression of MYO9A mRNA
CTD
PMID:25075043
NCBI chr 8:69,044,853...69,248,094
Ensembl chr 8:60,149,234...60,350,514
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Nampt
nicotinamide phosphoribosyltransferase
increases expression
ISO
alpha phellandrene results in increased expression of NAMPT mRNA
CTD
PMID:25075043
NCBI chr 6:55,152,756...55,189,547
Ensembl chr 6:49,424,332...49,462,100
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Nat10
N-acetyltransferase 10
decreases expression
ISO
alpha phellandrene results in decreased expression of NAT10 mRNA
CTD
PMID:25075043
NCBI chr 3:110,566,582...110,604,829
Ensembl chr 3:90,111,645...90,149,927
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Ndrg2
NDRG family member 2
increases expression
ISO
alpha phellandrene results in increased expression of NDRG2 mRNA
CTD
PMID:25075043
NCBI chr15:27,074,481...27,087,376
Ensembl chr15:24,600,982...24,609,626
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Nfil3
nuclear factor, interleukin 3 regulated
increases expression
ISO
alpha phellandrene results in increased expression of NFIL3 mRNA
CTD
PMID:25075043
NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,280,484...12,295,858
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Nfkbia
NFKB inhibitor alpha
increases expression
ISO
alpha phellandrene results in increased expression of NFKBIA mRNA
CTD
PMID:25075043
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
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Nhp2
NHP2 ribonucleoprotein
decreases expression
ISO
alpha phellandrene results in decreased expression of NHP2 mRNA
CTD
PMID:25075043
NCBI chr10:36,378,020...36,381,362
Ensembl chr10:35,877,054...35,882,545
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Nol10
nucleolar protein 10
decreases expression
ISO
alpha phellandrene results in decreased expression of NOL10 mRNA
CTD
PMID:25075043
NCBI chr 6:45,861,773...45,954,067
Ensembl chr 6:40,144,235...40,225,353
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Nol8
nucleolar protein 8
decreases expression
ISO
alpha phellandrene results in decreased expression of NOL8 mRNA
CTD
PMID:25075043
NCBI chr17:15,196,881...15,220,265
Ensembl chr17:14,990,417...15,013,848
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Nolc1
nucleolar and coiled-body phosphoprotein 1
decreases expression
ISO
alpha phellandrene results in decreased expression of NOLC1 mRNA
CTD
PMID:25075043
NCBI chr 1:254,870,195...254,881,070
Ensembl chr 1:244,921,377...244,932,088
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Nop2
NOP2 nucleolar protein
decreases expression
ISO
alpha phellandrene results in decreased expression of NOP2 mRNA
CTD
PMID:25075043
NCBI chr 4:159,618,894...159,630,697
Ensembl chr 4:157,932,716...157,944,459
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Nop56
NOP56 ribonucleoprotein
decreases expression
ISO
alpha phellandrene results in decreased expression of NOP56 mRNA
CTD
PMID:25075043
NCBI chr 3:137,926,187...137,934,971
Ensembl chr 3:117,477,053...117,481,841
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Nos2
nitric oxide synthase 2
increases expression
ISO
alpha phellandrene results in increased expression of NOS2 mRNA
CTD
PMID:25075043
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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Nxt2
nuclear transport factor 2-like export factor 2
increases expression
ISO
alpha phellandrene results in increased expression of NXT2 mRNA
CTD
PMID:25075043
NCBI chr X:110,652,434...110,659,738
Ensembl chr X:105,855,608...105,862,899
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Oas1a
2'-5' oligoadenylate synthetase 1A
increases expression
ISO
alpha phellandrene results in increased expression of OAS1A mRNA; alpha phellandrene results in increased expression of OAS1B mRNA
CTD
PMID:25075043
NCBI chr12:41,330,423...41,341,130
Ensembl chr12:35,669,801...35,680,517
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Oas3
2'-5'-oligoadenylate synthetase 3
increases expression
ISO
alpha phellandrene results in increased expression of OAS3 mRNA
CTD
PMID:25075043
NCBI chr12:41,439,645...41,463,392
Ensembl chr12:35,779,022...35,802,781
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Osbpl9
oxysterol binding protein-like 9
increases expression
ISO
alpha phellandrene results in increased expression of OSBPL9 mRNA
CTD
PMID:25075043
NCBI chr 5:129,047,776...129,190,838
Ensembl chr 5:123,819,104...123,962,196
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Pabir2
PABIR family member 2
increases expression
ISO
alpha phellandrene results in increased expression of PABIR2 mRNA
CTD
PMID:25075043
NCBI chr X:137,908,653...137,935,153
Ensembl chr X:132,989,124...133,015,580
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Parp14
poly (ADP-ribose) polymerase family, member 14
increases expression
ISO
alpha phellandrene results in increased expression of PARP14 mRNA
CTD
PMID:25075043
NCBI chr11:78,408,134...78,440,201
Ensembl chr11:64,902,785...64,934,916
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Pcyox1l
prenylcysteine oxidase 1 like
decreases expression
ISO
alpha phellandrene results in decreased expression of PCYOX1L mRNA
CTD
PMID:25075043
NCBI chr18:57,420,971...57,431,632
Ensembl chr18:55,150,650...55,161,327
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Pde3b
phosphodiesterase 3B
increases expression
ISO
alpha phellandrene results in increased expression of PDE3B mRNA
CTD
PMID:25075043
NCBI chr 1:178,041,207...178,204,503
Ensembl chr 1:168,607,022...168,769,334
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Phospho1
phosphoethanolamine/phosphocholine phosphatase 1
increases expression
ISO
alpha phellandrene results in increased expression of PHOSPHO1 mRNA
CTD
PMID:25075043
NCBI chr10:81,258,810...81,266,345
Ensembl chr10:80,760,792...80,770,342
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Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
increases expression
ISO
alpha phellandrene results in increased expression of PIK3CB mRNA
CTD
PMID:25075043
NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663
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Pld4
phospholipase D family, member 4
increases expression
ISO
alpha phellandrene results in increased expression of PLD4 mRNA
CTD
PMID:25075043
NCBI chr 6:137,639,948...137,647,462
Ensembl chr 6:131,818,860...131,826,376
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Plxdc1
plexin domain containing 1
increases expression
ISO
alpha phellandrene results in increased expression of PLXDC1 mRNA
CTD
PMID:25075043
NCBI chr10:83,418,837...83,478,451
Ensembl chr10:82,922,508...82,982,130
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Pnrc2
proline-rich nuclear receptor coactivator 2
increases expression
ISO
alpha phellandrene results in increased expression of PNRC2 mRNA
CTD
PMID:25075043
NCBI chr 5:153,387,522...153,390,506
Ensembl chr 5:148,095,699...148,107,242 Ensembl chr 5:148,095,699...148,107,242
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Polr1b
RNA polymerase I subunit B
decreases expression
ISO
alpha phellandrene results in decreased expression of POLR1B mRNA
CTD
PMID:25075043
NCBI chr 3:136,787,130...136,811,608
Ensembl chr 3:116,333,889...116,358,379
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Pop1
POP1 homolog, ribonuclease P/MRP subunit
decreases expression
ISO
alpha phellandrene results in decreased expression of POP1 mRNA
CTD
PMID:25075043
NCBI chr 7:67,590,502...67,618,187
Ensembl chr 7:65,705,368...65,733,141
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Ppan
peter pan homolog
decreases expression
ISO
alpha phellandrene results in decreased expression of PPAN mRNA
CTD
PMID:25075043
NCBI chr 8:27,700,147...27,704,127
Ensembl chr 8:19,423,961...19,427,938
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Ppat
phosphoribosyl pyrophosphate amidotransferase
decreases expression
ISO
alpha phellandrene results in decreased expression of PPAT mRNA
CTD
PMID:25075043
NCBI chr14:31,570,010...31,604,410
Ensembl chr14:31,216,165...31,250,144
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Ppm1k
protein phosphatase, Mg2+/Mn2+ dependent, 1K
increases expression
ISO
alpha phellandrene results in increased expression of PPM1K mRNA
CTD
PMID:25075043
NCBI chr 4:88,942,226...88,969,139
Ensembl chr 4:87,612,204...87,636,152
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Ppp2r5c
protein phosphatase 2, regulatory subunit B', gamma
increases expression
ISO
alpha phellandrene results in increased expression of PPP2R5C mRNA
CTD
PMID:25075043
NCBI chr 6:135,282,947...135,419,591
Ensembl chr 6:129,461,648...129,598,346
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Pprc1
PPARG related coactivator 1
decreases expression
ISO
alpha phellandrene results in decreased expression of PPRC1 mRNA
CTD
PMID:25075043
NCBI chr 1:254,851,136...254,867,570
Ensembl chr 1:244,902,179...244,918,587
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Prkdc
protein kinase, DNA-activated, catalytic subunit
decreases expression
ISO
alpha phellandrene results in decreased expression of PRKDC protein
CTD
PMID:24861204
NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952
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Prss1
serine protease 1
decreases expression
ISO
alpha phellandrene results in decreased expression of TRY10 mRNA
CTD
PMID:25075043
NCBI chr 4:71,331,249...71,334,452
Ensembl chr 4:70,364,586...70,367,792
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Ptbp3
polypyrimidine tract binding protein 3
increases expression
ISO
alpha phellandrene results in increased expression of PTBP3 mRNA
CTD
PMID:25075043
NCBI chr 5:79,108,376...79,194,533
Ensembl chr 5:74,315,101...74,399,791
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Ptpmt1
protein tyrosine phosphatase, mitochondrial 1
decreases expression
ISO
alpha phellandrene results in decreased expression of PTPMT1 mRNA
CTD
PMID:25075043
NCBI chr 3:97,345,752...97,355,396
Ensembl chr 3:76,889,922...76,899,427
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Ptpn7
protein tyrosine phosphatase, non-receptor type 7
decreases expression
ISO
alpha phellandrene results in decreased expression of PTPN7 mRNA
CTD
PMID:25075043
NCBI chr13:49,122,679...49,136,096
Ensembl chr13:46,571,712...46,583,308
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Pus7
pseudouridine synthase 7
decreases expression
ISO
alpha phellandrene results in decreased expression of PUS7 mRNA
CTD
PMID:25075043
NCBI chr 4:12,252,553...12,293,547
Ensembl chr 4:11,360,188...11,401,172
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Pus7l
pseudouridine synthase 7 like
decreases expression
ISO
alpha phellandrene results in decreased expression of PUS7L mRNA
CTD
PMID:25075043
NCBI chr 7:127,538,785...127,561,936
Ensembl chr 7:125,659,507...125,682,333
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Rad51c
RAD51 paralog C
increases expression
ISO
alpha phellandrene results in increased expression of RAD51C mRNA
CTD
PMID:25075043
NCBI chr10:72,702,299...72,728,980
Ensembl chr10:72,205,032...72,231,248
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Rap2b
RAP2B, member of RAS oncogene family
increases expression
ISO
alpha phellandrene results in increased expression of RAP2B mRNA
CTD
PMID:25075043
NCBI chr 2:147,749,387...147,749,938
Ensembl chr 2:145,599,116...145,603,069
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Rbm12b
RNA binding motif protein 12B
decreases expression
ISO
alpha phellandrene results in decreased expression of RBM12B2 mRNA
CTD
PMID:25075043
NCBI chr 5:30,394,756...30,507,428
Ensembl chr 5:25,590,493...25,611,245
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Rbpj
recombination signal binding protein for immunoglobulin kappa J region
increases expression
ISO
alpha phellandrene results in increased expression of RBPJ mRNA
CTD
PMID:25075043
NCBI chr14:61,551,366...61,736,220
Ensembl chr14:57,338,507...57,523,353
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Rcl1
RNA terminal phosphate cyclase-like 1
decreases expression
ISO
alpha phellandrene results in decreased expression of RCL1 mRNA
CTD
PMID:25075043
NCBI chr 1:236,238,078...236,282,597
Ensembl chr 1:226,824,534...226,902,315
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RGD1359108
similar to RIKEN cDNA 3110043O21
increases expression
ISO
alpha phellandrene results in increased expression of C9ORF72 mRNA
CTD
PMID:25075043
NCBI chr 5:54,562,570...54,587,649
Ensembl chr 5:49,766,325...49,791,408
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Rhobtb2
Rho-related BTB domain containing 2
increases expression
ISO
alpha phellandrene results in increased expression of RHOBTB2 mRNA
CTD
PMID:25075043
NCBI chr15:51,278,024...51,298,209
Ensembl chr15:44,870,376...44,888,651
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Rig1
RNA sensor RIG-1
increases expression
ISO
alpha phellandrene results in increased expression of RIGI mRNA
CTD
PMID:25075043
NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:55,321,235...55,370,819
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Rnf141
ring finger protein 141
increases expression
ISO
alpha phellandrene results in increased expression of RNF141 mRNA
CTD
PMID:25075043
NCBI chr 1:174,365,789...174,391,848
Ensembl chr 1:164,931,077...164,957,118
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Rnf19b
ring finger protein 19B
increases expression
ISO
alpha phellandrene results in increased expression of RNF19B mRNA
CTD
PMID:25075043
NCBI chr 5:146,690,453...146,715,729
Ensembl chr 5:141,406,118...141,431,380
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Rp2
RP2 activator of ARL3 GTPase
increases expression
ISO
alpha phellandrene results in increased expression of RP2 mRNA
CTD
PMID:25075043
NCBI chr X:4,426,071...4,470,200
Ensembl chr X:1,873,306...1,916,688
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Rpp14
ribonuclease P/MRP subunit p14
decreases expression
ISO
alpha phellandrene results in decreased expression of RPP14 mRNA
CTD
PMID:25075043
NCBI chr15:19,268,025...19,278,216
Ensembl chr15:16,836,859...16,852,101 Ensembl chr15:16,836,859...16,852,101
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Rpp38
ribonuclease P/MRP subunit p38
decreases expression
ISO
alpha phellandrene results in decreased expression of RPP38 mRNA
CTD
PMID:25075043
NCBI chr17:79,823,237...79,826,908
Ensembl chr17:74,908,932...74,927,431
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Rps12
ribosomal protein S12
decreases expression
ISO
alpha phellandrene results in decreased expression of RPS12 mRNA
CTD
PMID:25075043
NCBI chr 1:23,499,943...23,502,234
Ensembl chr 1:21,680,852...21,683,014
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Rras
RAS related
increases expression
ISO
alpha phellandrene results in increased expression of RRAS mRNA
CTD
PMID:25075043
NCBI chr 1:104,637,061...104,640,841
Ensembl chr 1:95,500,566...95,504,357
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Rrp12
ribosomal RNA processing 12
decreases expression
ISO
alpha phellandrene results in decreased expression of RRP12 mRNA
CTD
PMID:25075043
NCBI chr 1:250,621,707...250,655,318
Ensembl chr 1:240,672,382...240,706,018
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Rrp15
ribosomal RNA processing 15 homolog
decreases expression
ISO
alpha phellandrene results in decreased expression of RRP15 mRNA
CTD
PMID:25075043
NCBI chr13:100,807,729...100,830,812
Ensembl chr13:98,276,134...98,299,370
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Rsad2
radical S-adenosyl methionine domain containing 2
increases expression
ISO
alpha phellandrene results in increased expression of RSAD2 mRNA
CTD
PMID:25075043
NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:43,047,658...43,059,699
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Rtl1
retrotransposon-like 1
decreases expression
ISO
alpha phellandrene results in decreased expression of RTL1 mRNA
CTD
PMID:25075043
NCBI chr 6:134,325,231...134,335,780
Ensembl chr 6:128,543,939...128,549,182
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Rtl8a
retrotransposon Gag like 8A
increases expression
ISO
alpha phellandrene results in increased expression of RTL8A mRNA
CTD
PMID:25075043
NCBI chr X:138,436,824...138,438,037
Ensembl chr X:133,414,030...133,415,240
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Rtp4
receptor (chemosensory) transporter protein 4
increases expression
ISO
alpha phellandrene results in increased expression of RTP4 mRNA
CTD
PMID:25075043
NCBI chr11:90,741,992...90,840,061
Ensembl chr11:77,238,216...77,335,437
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Rubcnl
rubicon like autophagy enhancer
increases expression
ISO
alpha phellandrene results in increased expression of RUBCNL mRNA
CTD
PMID:25075043
NCBI chr15:56,741,897...56,807,086
Ensembl chr15:50,332,418...50,400,849
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Samhd1
SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
increases expression
ISO
alpha phellandrene results in increased expression of SAMHD1 mRNA
CTD
PMID:25075043
NCBI chr 3:166,179,742...166,214,448
Ensembl chr 3:145,761,558...145,794,386
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Sat1
spermidine/spermine N1-acetyl transferase 1
increases expression
ISO
alpha phellandrene results in increased expression of SAT1 mRNA
CTD
PMID:25075043
NCBI chr X:44,008,089...44,011,376
Ensembl chr X:40,157,046...40,196,813
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Sdad1
SDA1 domain containing 1
decreases expression
ISO
alpha phellandrene results in decreased expression of SDAD1 mRNA
CTD
PMID:25075043
NCBI chr14:16,025,726...16,052,565
Ensembl chr14:15,741,434...15,771,066
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Sec14l1
SEC14-like lipid binding 1
increases expression
ISO
alpha phellandrene results in increased expression of SEC14L1 mRNA
CTD
PMID:25075043
NCBI chr10:102,818,693...102,865,841
Ensembl chr10:102,319,920...102,367,068
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Selenbp1
selenium binding protein 1
increases expression
ISO
alpha phellandrene results in increased expression of SELENBP1 mRNA; alpha phellandrene results in increased expression of SELENBP2 mRNA
CTD
PMID:25075043
NCBI chr 2:185,183,022...185,193,612
Ensembl chr 2:182,493,978...182,504,594
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Sema3c
semaphorin 3C
decreases expression
ISO
alpha phellandrene results in decreased expression of SEMA3C mRNA
CTD
PMID:25075043
NCBI chr 4:18,538,452...18,702,453
Ensembl chr 4:17,583,212...17,746,534
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Senp2
SUMO specific peptidase 2
decreases expression
ISO
alpha phellandrene results in decreased expression of SENP2 mRNA
CTD
PMID:25075043
NCBI chr11:92,487,259...92,522,795
Ensembl chr11:78,981,432...79,018,238
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Septin8
septin 8
increases expression
ISO
alpha phellandrene results in increased expression of SEPT8 mRNA
CTD
PMID:25075043
NCBI chr10:38,185,454...38,214,502
Ensembl chr10:37,684,639...37,713,174
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Sertad3
SERTA domain containing 3
increases expression
ISO
alpha phellandrene results in increased expression of SERTAD3 mRNA
CTD
PMID:25075043
NCBI chr 1:91,891,141...91,894,861
Ensembl chr 1:82,763,149...82,769,001
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Set
Set nuclear proto-oncogene
decreases expression
ISO
alpha phellandrene results in decreased expression of SET mRNA
CTD
PMID:25075043
NCBI chr 3:33,732,319...33,743,433
Ensembl chr 3:13,335,041...13,363,567
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Sfn
stratifin
increases expression
ISO
alpha phellandrene results in increased expression of SFN protein
CTD
PMID:24861204
NCBI chr 5:151,110,582...151,111,854
Ensembl chr 5:145,826,201...145,831,314
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Sgf29
SAGA complex associated factor 29
decreases expression
ISO
alpha phellandrene results in decreased expression of SGF29 mRNA
CTD
PMID:25075043
NCBI chr 1:190,668,803...190,702,500
Ensembl chr 1:181,238,468...181,274,781
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Sgo2
shugoshin 2
increases expression
ISO
alpha phellandrene results in increased expression of SGO2A mRNA
CTD
PMID:25075043
NCBI chr 9:67,032,083...67,067,439
Ensembl chr 9:59,548,683...59,573,229
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Sigmar1
sigma non-opioid intracellular receptor 1
decreases expression
ISO
alpha phellandrene results in decreased expression of SIGMAR1 mRNA
CTD
PMID:25075043
NCBI chr 5:61,700,021...61,702,799
Ensembl chr 5:56,904,159...56,907,017
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Slc1a5
solute carrier family 1 member 5
decreases expression
ISO
alpha phellandrene results in decreased expression of SLC1A5 mRNA
CTD
PMID:25075043
NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:77,456,694...77,470,952
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Slc35b1
solute carrier family 35, member B1
decreases expression
ISO
alpha phellandrene results in decreased expression of SLC35B1 mRNA
CTD
PMID:25075043
NCBI chr10:80,824,972...80,832,048
Ensembl chr10:80,327,945...80,335,274
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Slc35d1
solute carrier family 35 member D1
decreases expression
ISO
alpha phellandrene results in decreased expression of SLC35D1 mRNA
CTD
PMID:25075043
NCBI chr 5:123,157,739...123,210,350
Ensembl chr 5:117,934,352...117,981,311
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Slc44a1
solute carrier family 44 member 1
increases expression
ISO
alpha phellandrene results in increased expression of SLC44A1 mRNA
CTD
PMID:25075043
NCBI chr 5:72,857,323...73,037,279
Ensembl chr 5:68,063,618...68,241,909
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Slc44a3
solute carrier family 44, member 3
increases expression
ISO
alpha phellandrene results in increased expression of SLC44A3 mRNA
CTD
PMID:25075043
NCBI chr 2:212,234,425...212,312,886
Ensembl chr 2:209,552,144...209,629,044
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Slc7a1
solute carrier family 7 member 1
decreases expression
ISO
alpha phellandrene results in decreased expression of SLC7A1 mRNA
CTD
PMID:25075043
NCBI chr12:11,664,488...11,740,030
Ensembl chr12:6,628,007...6,703,849
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Slc7a11
solute carrier family 7 member 11
decreases expression
ISO
alpha phellandrene results in decreased expression of SLC7A11 mRNA
CTD
PMID:25075043
NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536
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Slc7a6
solute carrier family 7 member 6
decreases expression
ISO
alpha phellandrene results in decreased expression of SLC7A6 mRNA
CTD
PMID:25075043
NCBI chr19:50,982,459...51,010,140
Ensembl chr19:34,074,286...34,100,268
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Slfn5
schlafen family member 5
increases expression
ISO
alpha phellandrene results in increased expression of SLFN4 mRNA; alpha phellandrene results in increased expression of SLFN5 mRNA
CTD
PMID:25075043
NCBI chr10:68,378,440...68,392,515
Ensembl chr10:67,880,009...67,893,109
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Smim14
small integral membrane protein 14
increases expression
ISO
alpha phellandrene results in increased expression of SMIM14 mRNA
CTD
PMID:25075043
NCBI chr14:43,136,754...43,180,622
Ensembl chr14:42,783,332...42,829,760
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Smox
spermine oxidase
increases expression
ISO
alpha phellandrene results in increased expression of SMOX mRNA
CTD
PMID:25075043
NCBI chr 3:139,184,793...139,220,174
Ensembl chr 3:118,731,900...118,765,710 Ensembl chr X:118,731,900...118,765,710
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Snora20
small nucleolar RNA, H/ACA box 20
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORA20 mRNA
CTD
PMID:25075043
NCBI chr 8:80,023,645...80,023,774
Ensembl chr 8:71,142,787...71,142,916
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Snora21
small nucleolar RNA, H/ACA box 21
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORA21 mRNA
CTD
PMID:25075043
NCBI chr 5:164,341,679...164,341,814
Ensembl chr10:82,775,114...82,775,249
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Snora26
small nucleolar RNA, H/ACA box 26
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORA26 mRNA
CTD
PMID:25075043
NCBI chr 5:43,082,153...43,082,272
Ensembl chr14:34,127,640...34,127,760
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Snora3a
small nucleolar RNA, H/ACA box 3A
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORA3 mRNA
CTD
PMID:25075043
NCBI chr 7:125,820,534...125,820,664
Ensembl chr 1:163,540,664...163,540,793
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Snora44
small nucleolar RNA, H/ACA box 44
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORA44 mRNA
CTD
PMID:25075043
NCBI chr 5:88,950,502...88,950,630
Ensembl chr 4:126,415,989...126,416,119
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Snora61
small nucleolar RNA, H/ACA box 61
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORA61 mRNA
CTD
PMID:25075043
NCBI chr 5:149,790,438...149,790,567
Ensembl chr 5:144,506,420...144,506,549
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Snora73b
small nucleolar RNA, H/ACA box 73b
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORA73B mRNA
CTD
PMID:25075043
NCBI chr 5:149,829,190...149,829,393
Ensembl chr 5:144,545,179...144,545,382
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Snora75
small nucleolar RNA, H/ACA box 75
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORA75 mRNA
CTD
PMID:25075043
NCBI chr 9:94,448,219...94,448,355
Ensembl chr 9:87,000,248...87,000,384
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Snord22
small nucleolar RNA, C/D box 22
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORD22 mRNA
CTD
PMID:25075043
NCBI chr11:22,544,203...22,544,327
Ensembl chr11:9,097,799...9,097,923
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Snord34
small nucleolar RNA, C/D box 34
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORD34 mRNA
CTD
PMID:25075043
NCBI chr 8:123,923,964...123,924,030
Ensembl chr 8:115,045,817...115,045,883
G
Snord52
small nucleolar RNA, C/D box 52
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORD52 mRNA
CTD
PMID:25075043
NCBI chr20:3,883,057...3,883,122
Ensembl chr20:3,878,412...3,878,477
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Snord82
small nucleolar RNA, C/D box 82
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORD82 mRNA
CTD
PMID:25075043
NCBI chr 9:94,452,486...94,452,557
Ensembl chr 9:87,004,515...87,004,586
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Snord87
small nucleolar RNA, C/D box 87
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORD87 mRNA
CTD
PMID:25075043
NCBI chr 5:14,080,356...14,080,440
Ensembl chr 5:9,297,489...9,297,573
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Snord95
small nucleolar RNA, C/D box 95
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORD95 mRNA
CTD
PMID:25075043
NCBI chr10:33,673,118...33,673,185
Ensembl chr10:33,171,983...33,172,050
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Snord96a
small nucleolar RNA, C/D box 96A
decreases expression
ISO
alpha phellandrene results in decreased expression of SNORD96A mRNA
CTD
PMID:25075043
NCBI chr10:33,672,228...33,672,307
Ensembl chr10:33,171,093...33,171,172
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Snrpd2
small nuclear ribonucleoprotein D2 polypeptide
decreases expression
ISO
alpha phellandrene results in decreased expression of SNRPD2 mRNA
CTD
PMID:25075043
NCBI chr 1:87,926,030...87,929,259
Ensembl chr 1:78,798,377...78,803,351 Ensembl chr20:78,798,377...78,803,351
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Sp100
SP100 nuclear antigen
increases expression
ISO
alpha phellandrene results in increased expression of SP100 mRNA
CTD
PMID:25075043
NCBI chr 9:93,758,975...93,825,068
Ensembl chr 9:86,311,032...86,377,034
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Sp140
SP140 nuclear body protein
increases expression
ISO
alpha phellandrene results in increased expression of SP140 mRNA
CTD
PMID:25075043
NCBI chr 9:93,672,536...93,722,596
Ensembl chr 9:86,224,513...86,274,542
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Spc25
SPC25 component of NDC80 kinetochore complex
increases expression
ISO
alpha phellandrene results in increased expression of SPC25 mRNA
CTD
PMID:25075043
NCBI chr 3:74,337,872...74,396,825
Ensembl chr 3:53,975,704...53,988,959
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Spred3
sprouty-related, EVH1 domain containing 3
increases expression
ISO
alpha phellandrene results in increased expression of SPRED3 mRNA
CTD
PMID:25075043
NCBI chr 1:93,586,259...93,597,692
Ensembl chr 1:84,459,314...84,470,249
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Sri
sorcin
increases expression
ISO
alpha phellandrene results in increased expression of SRI mRNA
CTD
PMID:25075043
NCBI chr 4:26,928,338...26,952,980
Ensembl chr 4:25,966,750...25,998,077
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Srm
spermidine synthase
decreases expression
ISO
alpha phellandrene results in decreased expression of SRM mRNA
CTD
PMID:25075043
NCBI chr 5:164,309,002...164,312,203
Ensembl chr 5:159,025,873...159,029,405
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Srr
serine racemase
increases expression
ISO
alpha phellandrene results in increased expression of SRR mRNA
CTD
PMID:25075043
NCBI chr10:60,267,936...60,285,094
Ensembl chr10:59,769,571...59,787,011
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Srsf7
serine and arginine rich splicing factor 7
decreases expression
ISO
alpha phellandrene results in decreased expression of SRSF7 mRNA
CTD
PMID:25075043
NCBI chr 6:20,564,035...20,571,205
Ensembl chr 6:14,811,808...14,818,965
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Ssr4
signal sequence receptor subunit 4
decreases expression
ISO
alpha phellandrene results in decreased expression of SSR4 mRNA
CTD
PMID:25075043
NCBI chr X:156,675,658...156,679,545
Ensembl chr X:151,524,009...151,528,202
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St8sia5
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5
decreases expression
ISO
alpha phellandrene results in decreased expression of ST8SIA5 mRNA
CTD
PMID:25075043
NCBI chr18:73,010,235...73,072,984
Ensembl chr18:70,736,602...70,797,789
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Stard3nl
STARD3 N-terminal like
increases expression
ISO
alpha phellandrene results in increased expression of STARD3NL mRNA
CTD
PMID:25075043
NCBI chr17:50,278,859...50,312,864
Ensembl chr17:45,583,266...45,617,226
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Stard5
StAR-related lipid transfer domain containing 5
increases expression
ISO
alpha phellandrene results in increased expression of STARD5 mRNA
CTD
PMID:25075043
NCBI chr 1:147,015,304...147,025,170
Ensembl chr 1:137,606,177...137,616,469
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Stat1
signal transducer and activator of transcription 1
increases expression
ISO
alpha phellandrene results in increased expression of STAT1 mRNA
CTD
PMID:25075043
NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540
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Stat2
signal transducer and activator of transcription 2
increases expression
ISO
alpha phellandrene results in increased expression of STAT2 mRNA
CTD
PMID:25075043
NCBI chr 7:1,287,025...1,302,858
Ensembl chr 7:702,495...718,967
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Supv3l1
Suv3 like RNA helicase
decreases expression
ISO
alpha phellandrene results in decreased expression of SUPV3L1 mRNA
CTD
PMID:25075043
NCBI chr20:30,921,248...30,941,779
Ensembl chr20:30,378,550...30,399,054
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Taf1d
TATA-box binding protein associated factor, RNA polymerase I subunit D
decreases expression
ISO
alpha phellandrene results in decreased expression of TAF1D mRNA
CTD
PMID:25075043
NCBI chr 8:20,427,894...20,438,046
Ensembl chr 8:12,146,605...12,156,618
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Tbxas1
thromboxane A synthase 1
decreases expression
ISO
alpha phellandrene results in decreased expression of TBXAS1 mRNA
CTD
PMID:25075043
NCBI chr 4:68,631,841...68,803,959
Ensembl chr 4:67,665,007...67,837,096
G
Tceanc
transcription elongation factor A N-terminal and central domain containing
increases expression
ISO
alpha phellandrene results in increased expression of TCEANC mRNA
CTD
PMID:25075043
NCBI chr X:31,587,207...31,592,694
Ensembl chr X:27,952,457...27,960,940
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Tcp11l2
t-complex 11 like 2
increases expression
ISO
alpha phellandrene results in increased expression of TCP11L2 mRNA
CTD
PMID:25075043
NCBI chr 7:21,037,955...21,072,857
Ensembl chr 7:19,150,252...19,185,095
G
Tctn3
tectonic family member 3
increases expression
ISO
alpha phellandrene results in increased expression of TCTN3 mRNA
CTD
PMID:25075043
NCBI chr 1:249,363,428...249,374,698
Ensembl chr 1:239,415,203...239,425,272
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Tdrd7
tudor domain containing 7
increases expression
ISO
alpha phellandrene results in increased expression of TDRD7 mRNA
CTD
PMID:25075043
NCBI chr 5:65,034,317...65,108,165
Ensembl chr 5:60,238,678...60,312,544
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Tepsin
TEPSIN, adaptor related protein complex 4 accessory protein
decreases expression
ISO
alpha phellandrene results in decreased expression of TEPSIN mRNA
CTD
PMID:25075043
NCBI chr10:105,872,363...105,879,731
Ensembl chr10:105,373,941...105,382,266
G
Tesk2
testis associated actin remodelling kinase 2
increases expression
ISO
alpha phellandrene results in increased expression of TESK2 mRNA
CTD
PMID:25075043
NCBI chr 5:135,415,352...135,507,226
Ensembl chr 5:130,185,033...130,271,292
G
Tfap4
transcription factor AP-4
decreases expression
ISO
alpha phellandrene results in decreased expression of TFAP4 mRNA
CTD
PMID:25075043
NCBI chr10:11,507,242...11,525,794
Ensembl chr10:11,002,911...11,019,386
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Thg1l
tRNA-histidine guanylyltransferase 1-like
decreases expression
ISO
alpha phellandrene results in decreased expression of THG1L mRNA
CTD
PMID:25075043
NCBI chr10:30,889,259...30,897,903
Ensembl chr10:30,387,940...30,396,687
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Timm10
translocase of inner mitochondrial membrane 10
decreases expression
ISO
alpha phellandrene results in decreased expression of TIMM10 mRNA
CTD
PMID:25075043
NCBI chr 3:90,315,048...90,318,613
Ensembl chr 3:69,908,456...69,911,940
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Tmem120a
transmembrane protein 120A
decreases expression
ISO
alpha phellandrene results in decreased expression of TMEM120A mRNA
CTD
PMID:25075043
NCBI chr12:26,578,859...26,587,524
Ensembl chr12:20,942,439...20,990,316
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Tmem97
transmembrane protein 97
decreases expression
ISO
alpha phellandrene results in decreased expression of TMEM97 mRNA
CTD
PMID:25075043
NCBI chr10:63,936,276...63,945,359
Ensembl chr10:63,438,222...63,589,730
G
Tmsb10
thymosin, beta 10
increases expression
ISO
alpha phellandrene results in increased expression of TMSB10 mRNA
CTD
PMID:25075043
NCBI chr 4:106,568,080...106,569,210
Ensembl chr 4:105,009,212...105,011,028
G
Tmsb4x
thymosin beta 4, X-linked
increases expression
ISO
alpha phellandrene results in increased expression of TMSB4X mRNA
CTD
PMID:25075043
NCBI chr X:30,761,611...30,763,612
Ensembl chr X:27,128,610...27,146,667 Ensembl chr10:27,128,610...27,146,667
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Tp53
tumor protein p53
increases phosphorylation affects localization decreases expression increases expression
ISO
alpha phellandrene results in increased phosphorylation of TRP53 protein alpha phellandrene affects the localization of TP53 protein alpha phellandrene results in decreased expression of TRP53 protein alpha phellandrene results in increased expression of TRP53 protein modified form
CTD
PMID:24861204 PMID:25649747
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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Tpd52
tumor protein D52
increases expression
ISO
alpha phellandrene results in increased expression of TPD52 mRNA
CTD
PMID:25075043
NCBI chr 2:94,642,514...94,723,442
Ensembl chr 2:92,735,620...92,816,622
G
Tpm4
tropomyosin 4
increases expression
ISO
alpha phellandrene results in increased expression of TPM4 mRNA
CTD
PMID:25075043
NCBI chr16:17,718,442...17,732,483
Ensembl chr16:17,683,195...17,705,984
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Trim21
tripartite motif-containing 21
increases expression
ISO
alpha phellandrene results in increased expression of TRIM21 mRNA
CTD
PMID:25075043
NCBI chr 1:166,376,829...166,399,441
Ensembl chr 1:156,964,913...156,987,440
G
Tspoap1
TSPO associated protein 1
increases expression
ISO
alpha phellandrene results in increased expression of TSPOAP1 mRNA
CTD
PMID:25075043
NCBI chr10:73,053,414...73,083,640
Ensembl chr10:72,560,980...72,586,412
G
Tsr1
TSR1, ribosome maturation factor
decreases expression
ISO
alpha phellandrene results in decreased expression of TSR1 mRNA
CTD
PMID:25075043
NCBI chr10:60,258,790...60,270,238
Ensembl chr10:59,760,409...59,771,864
G
Tstd3
thiosulfate sulfurtransferase like domain containing 3
increases expression
ISO
alpha phellandrene results in increased expression of TSTD3 mRNA
CTD
PMID:25075043
NCBI chr 5:40,091,438...40,101,509
Ensembl chr 5:35,294,645...35,304,101
G
Ttc27
tetratricopeptide repeat domain 27
decreases expression
ISO
alpha phellandrene results in decreased expression of TTC27 mRNA
CTD
PMID:25075043
NCBI chr 6:26,310,696...26,454,045
Ensembl chr 6:20,558,756...20,702,115
G
Ubash3a
ubiquitin associated and SH3 domain containing, A
decreases expression
ISO
alpha phellandrene results in decreased expression of UBASH3A mRNA
CTD
PMID:25075043
NCBI chr20:9,292,819...9,336,036
Ensembl chr20:9,292,139...9,329,224
G
Ube2h
ubiquitin-conjugating enzyme E2H
increases expression
ISO
alpha phellandrene results in increased expression of UBE2H mRNA
CTD
PMID:25075043
NCBI chr 4:59,802,102...59,897,583
Ensembl chr 4:58,834,674...58,930,156
G
Urb2
URB2 ribosome biogenesis homolog
decreases expression
ISO
alpha phellandrene results in decreased expression of URB2 mRNA
CTD
PMID:25075043
NCBI chr19:68,908,466...68,934,058
Ensembl chr19:52,011,112...52,036,597
G
Usp18
ubiquitin specific peptidase 18
increases expression
ISO
alpha phellandrene results in increased expression of USP18 mRNA
CTD
PMID:25075043
NCBI chr 4:156,143,770...156,171,292
Ensembl chr 4:154,471,592...154,499,144
G
Usp22
ubiquitin specific peptidase 22
increases expression
ISO
alpha phellandrene results in increased expression of USP22 mRNA
CTD
PMID:25075043
NCBI chr10:46,328,092...46,354,939
Ensembl chr10:45,828,622...45,855,497
G
Usp36
ubiquitin specific peptidase 36
decreases expression
ISO
alpha phellandrene results in decreased expression of USP36 mRNA
CTD
PMID:25075043
NCBI chr10:103,995,970...104,027,492
Ensembl chr10:103,497,349...103,528,877
G
Utp20
UTP20 small subunit processome component
decreases expression
ISO
alpha phellandrene results in decreased expression of UTP20 mRNA
CTD
PMID:25075043
NCBI chr 7:25,022,029...25,103,024
Ensembl chr 7:23,134,637...23,215,632
G
Wdr12
WD repeat domain 12
decreases expression
ISO
alpha phellandrene results in decreased expression of WDR12 mRNA
CTD
PMID:25075043
NCBI chr 9:68,969,547...68,996,811
Ensembl chr 9:61,475,517...61,502,469
G
Wdr3
WD repeat domain 3
decreases expression
ISO
alpha phellandrene results in decreased expression of WDR3 mRNA
CTD
PMID:25075043
NCBI chr 2:190,194,474...190,217,087
Ensembl chr 2:187,505,816...187,528,432
G
Wdr74
WD repeat domain 74
decreases expression
ISO
alpha phellandrene results in decreased expression of WDR74 mRNA
CTD
PMID:25075043
NCBI chr 1:215,060,901...215,065,687
Ensembl chr 1:205,631,824...205,636,563
G
Wdr75
WD repeat domain 75
decreases expression
ISO
alpha phellandrene results in decreased expression of WDR75 mRNA
CTD
PMID:25075043
NCBI chr 9:55,395,232...55,425,412
Ensembl chr 9:47,903,200...47,933,399
G
Wdsub1
WD repeat, sterile alpha motif and U-box domain containing 1
increases expression
ISO
alpha phellandrene results in increased expression of WDSUB1 mRNA
CTD
PMID:25075043
NCBI chr 3:64,749,118...64,781,525
Ensembl chr 3:44,340,415...44,370,891
G
Wipi1
WD repeat domain, phosphoinositide interacting 1
increases expression
ISO
alpha phellandrene results in increased expression of WIPI1 mRNA
CTD
PMID:25075043
NCBI chr10:95,042,451...95,079,679
Ensembl chr10:94,542,946...94,579,846
G
Xaf1
XIAP associated factor 1
increases expression
ISO
alpha phellandrene results in increased expression of XAF1 mRNA
CTD
PMID:25075043
NCBI chr10:57,415,935...57,428,348
Ensembl chr10:56,917,121...56,929,770
G
Yars2
tyrosyl-tRNA synthetase 2
decreases expression
ISO
alpha phellandrene results in decreased expression of YARS2 mRNA
CTD
PMID:25075043
NCBI chr11:98,136,530...98,142,320
Ensembl chr11:84,624,369...84,638,125
G
Zbp1
Z-DNA binding protein 1
increases expression
ISO
alpha phellandrene results in increased expression of ZBP1 mRNA
CTD
PMID:25075043
NCBI chr 3:182,411,665...182,427,604
Ensembl chr 3:161,993,351...162,003,870
G
Zfp26
zinc finger protein 26
decreases expression
ISO
alpha phellandrene results in decreased expression of ZFP882 mRNA
CTD
PMID:25075043
NCBI chr 8:27,235,912...27,261,879
Ensembl chr 8:18,965,271...18,988,325
G
Zfp260
zinc finger protein 260
increases expression
ISO
alpha phellandrene results in increased expression of ZFP260 mRNA
CTD
PMID:25075043
NCBI chr 1:94,469,861...94,477,377
Ensembl chr 1:85,336,618...85,350,067
G
Zfp346
zinc finger protein 346
decreases expression
ISO
alpha phellandrene results in decreased expression of ZFP346 mRNA
CTD
PMID:25075043
NCBI chr17:9,498,933...9,528,824
Ensembl chr17:9,493,803...9,523,635
G
Zfp39
zinc finger protein 39
increases expression
ISO
alpha phellandrene results in increased expression of ZFP719 mRNA
CTD
PMID:25075043
NCBI chr10:44,156,031...44,179,332
Ensembl chr10:43,656,444...43,679,743
G
Nr1h4
nuclear receptor subfamily 1, group H, member 4
increases expression
ISO
ankaflavin results in increased expression of NR1H4 mRNA
CTD
PMID:24275089
NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:23,846,122...23,942,047
G
Ppara
peroxisome proliferator activated receptor alpha
increases expression multiple interactions
ISO
ankaflavin results in increased expression of PPARA mRNA ankaflavin affects the reaction [PPARA protein affects the oxidation of Fatty Acids]; ankaflavin binds to and results in increased activity of PPARA protein
CTD
PMID:24275089
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
G
Ppargc1a
PPARG coactivator 1 alpha
increases expression
ISO
ankaflavin results in increased expression of PPARGC1A mRNA
CTD
PMID:24275089
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
G
Casp3
caspase 3
increases activity
ISO
azadiradione results in increased activity of CASP3 protein
CTD
PMID:21381696
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
G
Casp8
caspase 8
increases activity
ISO
azadiradione results in increased activity of CASP8 protein
CTD
PMID:21381696
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
G
Casp9
caspase 9
increases activity
ISO
azadiradione results in increased activity of CASP9 protein
CTD
PMID:21381696
Ensembl chr 5:154,109,046...154,126,626
G
Hspa1a
heat shock protein family A (Hsp70) member 1A
increases expression
ISO
azadiradione results in increased expression of HSPA1A mRNA
CTD
PMID:30309986
NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227
G
Adra1b
adrenoceptor alpha 1B
decreases activity
ISO
bardoxolone methyl results in decreased activity of ADRA1B protein
CTD
PMID:28790194
NCBI chr10:28,756,461...28,874,831
Ensembl chr10:28,255,025...28,312,919
G
Adra2c
adrenoceptor alpha 2C
decreases activity
ISO
bardoxolone methyl results in decreased activity of ADRA2C protein
CTD
PMID:28790194
NCBI chr14:79,695,514...79,697,476
Ensembl chr14:75,471,143...75,472,846
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased phosphorylation of AKT1 protein]
CTD
PMID:27417254
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
G
Anxa1
annexin A1
affects expression
ISO
bardoxolone methyl affects the expression of ANXA1 mRNA
CTD
PMID:34480604
NCBI chr 1:227,287,713...227,306,739
Ensembl chr 1:217,861,175...217,877,343
G
Arg1
arginase 1
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of ARG1 mRNA]
CTD
PMID:26918785
NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:20,475,968...20,488,422
G
Aurkb
aurora kinase B
decreases activity
ISO
bardoxolone methyl results in decreased activity of AURKB protein
CTD
PMID:28790194
NCBI chr10:54,243,116...54,249,675
Ensembl chr10:53,745,142...53,750,837
G
Avpr1a
arginine vasopressin receptor 1A
decreases activity
ISO
bardoxolone methyl results in decreased activity of AVPR1A protein
CTD
PMID:28790194
NCBI chr 7:59,999,743...60,003,667
Ensembl chr 7:58,114,284...58,122,215
G
B4galt1
beta-1,4-galactosyltransferase 1
increases expression
ISO
bardoxolone methyl results in increased expression of B4GALT1 mRNA
CTD
PMID:35724838
NCBI chr 5:60,731,601...60,778,456
Ensembl chr 5:55,935,615...55,982,461
G
Bbc3
Bcl-2 binding component 3
increases expression
ISO
bardoxolone methyl results in increased expression of BBC3 mRNA
CTD
PMID:35724838
NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509
G
Bdnf
brain-derived neurotrophic factor
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased expression of BDNF protein]
CTD
PMID:27417254
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
G
Birc3
baculoviral IAP repeat-containing 3
increases expression
ISO
bardoxolone methyl results in increased expression of BIRC3 mRNA
CTD
PMID:35724838
NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802
G
Cacna1c
calcium voltage-gated channel subunit alpha1 C
decreases activity
ISO
bardoxolone methyl results in decreased activity of CACNA1C protein
CTD
PMID:28790194
NCBI chr 4:153,431,169...154,051,932
Ensembl chr 4:151,764,138...152,379,648
G
Casp8
caspase 8
decreases expression
ISO
bardoxolone methyl results in decreased expression of CASP8 protein
CTD
PMID:25246272
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
G
Ccl11
C-C motif chemokine ligand 11
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL11 protein]
CTD
PMID:26918785
NCBI chr10:67,525,975...67,530,576
Ensembl chr10:67,028,328...67,032,926
G
Ccl2
C-C motif chemokine ligand 2
multiple interactions increases expression
ISO
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL2 protein] bardoxolone methyl results in increased expression of CCL2 mRNA
CTD
PMID:26918785 PMID:35724838
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
G
Ccl20
C-C motif chemokine ligand 20
increases expression
ISO
bardoxolone methyl results in increased expression of CCL20 mRNA
CTD
PMID:35724838
NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:84,388,904...84,391,629
G
Ccl3
C-C motif chemokine ligand 3
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL3 protein]
CTD
PMID:26918785
NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938
G
Ccl4
C-C motif chemokine ligand 4
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL4 protein]
CTD
PMID:26918785
NCBI chr10:68,963,893...68,965,728
Ensembl chr10:68,452,052...68,468,231
G
Ccl5
C-C motif chemokine ligand 5
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL5 protein]
CTD
PMID:26918785
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
G
Ccr5
C-C motif chemokine receptor 5
multiple interactions
ISO
bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of CCR5 mRNA]
CTD
PMID:26918785
NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:123,752,325...123,759,260
G
Cd163
CD163 molecule
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of CD163 mRNA]; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of CD163 protein]
CTD
PMID:26918785
NCBI chr 4:158,770,751...158,804,146
Ensembl chr 4:157,085,093...157,117,878
G
Chrm1
cholinergic receptor, muscarinic 1
decreases activity
ISO
bardoxolone methyl results in decreased activity of CHRM1 protein
CTD
PMID:28790194
NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:205,567,220...205,582,356
G
Chrm2
cholinergic receptor, muscarinic 2
decreases activity
ISO
bardoxolone methyl results in decreased activity of CHRM2 protein
CTD
PMID:28790194
NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,014,144...65,149,103
G
Clec10a
C-type lectin domain containing 10A
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of CLEC10A mRNA]
CTD
PMID:26918785
NCBI chr10:55,374,914...55,379,110
Ensembl chr10:54,876,260...54,880,435
G
Cxcl1
C-X-C motif chemokine ligand 1
increases expression
ISO
bardoxolone methyl results in increased expression of CXCL1 mRNA
CTD
PMID:35724838
NCBI chr14:17,477,542...17,479,321
Ensembl chr14:17,193,365...17,195,215
G
Cxcl2
C-X-C motif chemokine ligand 2
multiple interactions increases expression
ISO
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CXCL2 protein] bardoxolone methyl results in increased expression of CXCL2 mRNA
CTD
PMID:26918785 PMID:35724838
NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075
G
Cxcl3
C-X-C motif chemokine ligand 3
increases expression
ISO
bardoxolone methyl results in increased expression of CXCL1 mRNA
CTD
PMID:35724838
NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511
G
Ddit3
DNA-damage inducible transcript 3
multiple interactions increases expression
ISO
ochratoxin A promotes the reaction [bardoxolone methyl results in increased expression of DDIT3 protein]; Ursolic Acid inhibits the reaction [ochratoxin A promotes the reaction [bardoxolone methyl results in increased expression of DDIT3 protein]]
CTD
PMID:35724838 PMID:36587836
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
G
Dnajb1
DnaJ heat shock protein family (Hsp40) member B1
affects expression
ISO
bardoxolone methyl affects the expression of DNAJB1 mRNA
CTD
PMID:34480604
NCBI chr19:41,427,453...41,431,141
Ensembl chr19:24,522,717...24,526,458
G
Drd1
dopamine receptor D1
decreases activity
ISO
bardoxolone methyl results in decreased activity of DRD1 protein
CTD
PMID:28790194
NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002
G
Drd2
dopamine receptor D2
decreases activity
ISO
bardoxolone methyl results in decreased activity of DRD2 protein
CTD
PMID:28790194
NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875
G
Edn1
endothelin 1
increases expression
ISO
bardoxolone methyl results in increased expression of EDN1 mRNA
CTD
PMID:35724838
NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885
G
Egln3
egl-9 family hypoxia-inducible factor 3
affects expression
ISO
bardoxolone methyl affects the expression of EGLN3 mRNA
CTD
PMID:34480604
NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:71,650,297...71,675,766
G
Eif4ebp1
eukaryotic translation initiation factor 4E binding protein 1
multiple interactions
ISO
bardoxolone methyl results in decreased expression of and results in decreased phosphorylation of EIF4EBP1 protein
CTD
PMID:35929395
NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984
G
Fasn
fatty acid synthase
decreases expression
ISO
bardoxolone methyl results in decreased expression of FASN mRNA
CTD
PMID:20372807
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
G
Fmo2
flavin containing dimethylaniline monoxygenase 2
increases expression
ISO
bardoxolone methyl results in increased expression of FMO2 mRNA
CTD
PMID:25056779
NCBI chr13:77,755,131...77,777,597
Ensembl chr13:75,224,402...75,244,308
G
Foxo1
forkhead box O1
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of and results in decreased phosphorylation of FOXO1 protein]
CTD
PMID:27417254
NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
affects expression
ISO
bardoxolone methyl affects the expression of GADD45A mRNA
CTD
PMID:34480604
NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression decreases expression
ISO
bardoxolone methyl results in increased expression of GCLC mRNA; bardoxolone methyl results in increased expression of GCLC protein bardoxolone methyl results in decreased expression of GCLC mRNA
CTD
PMID:27480280 PMID:34480604 PMID:35724838
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
increases expression decreases expression
ISO
bardoxolone methyl results in increased expression of GCLM; bardoxolone methyl results in increased expression of GCLM mRNA bardoxolone methyl results in decreased expression of GCLM mRNA
CTD
PMID:21723306 PMID:34480604 PMID:35724838
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535
G
Gpx2
glutathione peroxidase 2
affects expression
ISO
bardoxolone methyl affects the expression of GPX2 mRNA
CTD
PMID:34480604
NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:95,493,589...95,496,877
G
Gsk3b
glycogen synthase kinase 3 beta
multiple interactions increases phosphorylation
ISO
GSK3B protein mutant form inhibits the reaction [bardoxolone methyl results in increased expression of HMOX1 protein]; GSK3B protein mutant form inhibits the reaction [bardoxolone methyl results in increased phosphorylation of GSK3B protein]
CTD
PMID:25246272
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
G
Gsta1
glutathione S-transferase alpha 1
decreases expression
ISO
bardoxolone methyl results in decreased expression of GSTA1 mRNA
CTD
PMID:34480604
NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:23,703,477...23,720,121
G
Gstp1
glutathione S-transferase pi 1
increases expression
ISO
bardoxolone methyl results in increased expression of GSTP1 mRNA
CTD
PMID:34480604
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
G
Hmox1
heme oxygenase 1
multiple interactions decreases expression increases expression
ISO
bardoxolone methyl inhibits the reaction [eriodictyol results in decreased expression of HMOX1 protein]; GSK3B protein mutant form inhibits the reaction [bardoxolone methyl results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [bardoxolone methyl results in increased expression of HMOX1 protein] bardoxolone methyl results in decreased expression of HMOX1 mRNA bardoxolone methyl results in increased expression of HMOX1 mRNA; bardoxolone methyl results in increased expression of HMOX1 protein [bardoxolone methyl co-treated with aristolochic acid I] results in increased expression of HMOX1 mRNA; bardoxolone methyl promotes the reaction [aristolochic acid I results in increased expression of HMOX1 protein]
CTD
PMID:21289052 PMID:24530882 PMID:25246272 PMID:28790194 PMID:34480604 PMID:35724838 PMID:37020356 More...
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
G
Hrh1
histamine receptor H 1
decreases activity
ISO
bardoxolone methyl results in decreased activity of HRH1 protein
CTD
PMID:28790194
NCBI chr 4:149,120,511...149,204,267
Ensembl chr 4:147,645,995...147,647,455
G
Hsf1
heat shock transcription factor 1
increases activity
ISO
bardoxolone methyl results in increased activity of HSF1 protein
CTD
PMID:34170685
NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:108,196,056...108,223,011
G
Hspa5
heat shock protein family A (Hsp70) member 5
multiple interactions increases expression
ISO
ochratoxin A promotes the reaction [bardoxolone methyl results in increased expression of HSPA5 protein]
CTD
PMID:35724838 PMID:36587836
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
G
Htr2a
5-hydroxytryptamine receptor 2A
decreases activity
ISO
bardoxolone methyl results in decreased activity of HTR2A protein
CTD
PMID:28790194
NCBI chr15:56,360,647...56,428,703
Ensembl chr15:49,950,804...50,020,928
G
Htr2c
5-hydroxytryptamine receptor 2C
decreases activity
ISO
bardoxolone methyl results in decreased activity of HTR2C protein
CTD
PMID:28790194
NCBI chr X:115,453,190...115,682,325
Ensembl chr X:110,641,153...110,870,287
G
Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; bardoxolone methyl inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]
CTD
PMID:35724838
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
G
Ifng
interferon gamma
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [IFNG protein results in increased expression of NOS2]
CTD
PMID:17363558
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
G
Il10
interleukin 10
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL10 protein]; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]
CTD
PMID:26918785
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
G
Il17a
interleukin 17A
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL17A protein]
CTD
PMID:26918785
NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889
G
Il1b
interleukin 1 beta
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; bardoxolone methyl inhibits the reaction [IL1B protein affects the localization of RELA protein]; bardoxolone methyl inhibits the reaction [IL1B protein results in increased expression of ICAM1 protein]; bardoxolone methyl inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]
CTD
PMID:35724838
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
G
Il1r1
interleukin 1 receptor type 1
affects expression
ISO
bardoxolone methyl affects the expression of IL1R1 mRNA
CTD
PMID:34480604
NCBI chr 9:50,000,558...50,076,579
Ensembl chr 9:42,504,735...42,579,937
G
Il6
interleukin 6
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]; bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]
CTD
PMID:26918785 PMID:27417254
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
G
Ins2
insulin 2
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [INS protein results in increased phosphorylation of RPS6 protein]
CTD
PMID:28790194
NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775
G
Irf5
interferon regulatory factor 5
multiple interactions
ISO
bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of IRF5 mRNA]
CTD
PMID:26918785
NCBI chr 4:59,092,914...59,104,596
Ensembl chr 4:58,127,640...58,139,267
G
Jak2
Janus kinase 2
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased phosphorylation of JAK2 protein]
CTD
PMID:27417254
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
G
Keap1
Kelch-like ECH-associated protein 1
increases expression decreases expression multiple interactions
ISO
bardoxolone methyl results in increased expression of KEAP1 protein bardoxolone methyl results in decreased expression of KEAP1 mRNA bardoxolone methyl inhibits the reaction [aristolochic acid I results in increased expression of KEAP1 protein]
CTD
PMID:24530882 PMID:27358234 PMID:35724838
NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862
G
Lep
leptin
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased susceptibility to LEP protein]; bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of LEP protein]
CTD
PMID:27417254
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
G
Lif
LIF, interleukin 6 family cytokine
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of LIF protein]
CTD
PMID:26918785
NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482
G
Lonp1
lon peptidase 1, mitochondrial
decreases expression
ISO
bardoxolone methyl results in decreased expression of LONP1 protein
CTD
PMID:36587836
NCBI chr 9:1,534,581...1,546,908
Ensembl chr 9:1,447,447...1,459,771
G
Mafg
MAF bZIP transcription factor G
affects expression decreases expression
ISO
bardoxolone methyl affects the expression of MAFG mRNA bardoxolone methyl results in decreased expression of MAFG mRNA
CTD
PMID:34480604 PMID:35724838
NCBI chr10:106,401,633...106,410,159
Ensembl chr10:105,903,237...105,912,026
G
Mfn1
mitofusin 1
decreases expression
ISO
bardoxolone methyl results in decreased expression of MFN1 protein
CTD
PMID:35929395
NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:115,313,401...115,359,640
G
Mfn2
mitofusin 2
decreases expression
ISO
bardoxolone methyl results in decreased expression of MFN2 protein
CTD
PMID:35929395
NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:158,304,287...158,335,342
G
Mrc1
mannose receptor, C type 1
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of MRC1 protein]
CTD
PMID:26918785
NCBI chr17:82,157,725...82,239,411
Ensembl chr17:77,249,187...77,330,857
G
Mtor
mechanistic target of rapamycin kinase
decreases phosphorylation
ISO
bardoxolone methyl results in decreased phosphorylation of MTOR protein
CTD
PMID:35929395
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions increases localization increases expression decreases response to substance increases activity
ISO EXP
bardoxolone methyl inhibits the reaction [eriodictyol results in decreased phosphorylation of NFE2L2 protein]; bardoxolone methyl results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 promotes the reaction [bardoxolone methyl results in increased expression of SRXN1 protein]; NFE2L2 protein affects the reaction [bardoxolone methyl results in increased expression of HMOX1 protein] bardoxolone methyl results in increased localization of NFE2L2 protein bardoxolone methyl results in increased expression of NFE2L2 mRNA; bardoxolone methyl results in increased expression of NFE2L2 protein NFE2L2 gene mutant form results in decreased susceptibility to bardoxolone methyl bardoxolone methyl results in increased activity of NFE2L2 protein bardoxolone methyl inhibits the reaction [aristolochic acid I results in decreased expression of and affects the localization of NFE2L2 protein]; bardoxolone methyl inhibits the reaction [aristolochic acid I results in decreased expression of NFE2L2 mRNA]
CTD
PMID:21289052 PMID:21723306 PMID:24530882 PMID:24798383 PMID:25246272 PMID:27358234 PMID:27633142 PMID:28790194 PMID:35724838 PMID:37020356 More...
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
G
Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased expression of NFKBIA protein] bardoxolone methyl inhibits the reaction [IL1B protein affects the localization of NFKBIA protein]; bardoxolone methyl inhibits the reaction [TNF protein affects the localization of NFKBIA protein]
CTD
PMID:25637688 PMID:35724838
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
G
Nfkbie
NFKB inhibitor epsilon
increases expression
ISO
bardoxolone methyl results in increased expression of NFKBIE mRNA
CTD
PMID:35724838
NCBI chr 9:22,941,037...22,947,872
Ensembl chr 9:15,436,941...15,450,437
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [IFNG protein results in increased expression of NOS2]
CTD
PMID:17363558
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
G
Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions decreases expression increases activity increases expression
ISO
[bardoxolone methyl co-treated with aristolochic acid I] results in increased expression of NQO1 mRNA; [bardoxolone methyl co-treated with aristolochic acid I] results in increased expression of NQO1 protein bardoxolone methyl inhibits the reaction [eriodictyol results in decreased expression of NQO1 protein] bardoxolone methyl results in decreased expression of NQO1 mRNA bardoxolone methyl results in increased activity of NQO1 protein bardoxolone methyl results in increased expression of NQO1 mRNA; bardoxolone methyl results in increased expression of NQO1 protein
CTD
PMID:24530882 PMID:27480280 PMID:28790194 PMID:34480604 PMID:35724838 PMID:37020356 More...
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
G
Olr1
oxidized low density lipoprotein receptor 1
increases expression
ISO
bardoxolone methyl results in increased expression of OLR1 mRNA
CTD
PMID:35724838
NCBI chr 4:164,612,460...164,635,082
Ensembl chr 4:162,926,439...162,948,523
G
Opa1
OPA1, mitochondrial dynamin like GTPase
increases cleavage
ISO
bardoxolone methyl results in increased cleavage of OPA1 protein
CTD
PMID:35929395
NCBI chr11:84,612,943...84,690,025
Ensembl chr11:71,109,873...71,185,109
G
Oprk1
opioid receptor, kappa 1
decreases activity
ISO
bardoxolone methyl results in decreased activity of OPRK1 protein
CTD
PMID:28790194
NCBI chr 5:18,657,866...18,675,671
Ensembl chr 5:13,860,021...13,877,823
G
Oprm1
opioid receptor, mu 1
decreases activity
ISO
bardoxolone methyl results in decreased activity of OPRM1 protein
CTD
PMID:28790194
NCBI chr 1:45,565,371...45,818,722
Ensembl chr 1:43,160,057...43,413,409
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO
bardoxolone methyl results in increased cleavage of PARP1 protein
CTD
PMID:17363558 PMID:25246272
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
G
Pde4b
phosphodiesterase 4B
decreases activity
ISO
bardoxolone methyl results in decreased activity of PDE4B protein
CTD
PMID:28790194
NCBI chr 5:122,028,956...122,598,267
Ensembl chr 5:116,799,971...117,367,696
G
Pdgfb
platelet derived growth factor subunit B
increases expression
ISO
bardoxolone methyl results in increased expression of PDGFB mRNA
CTD
PMID:35724838
NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984
G
Pfkm
phosphofructokinase, muscle
decreases expression
ISO
bardoxolone methyl results in decreased expression of PFKM protein
CTD
PMID:35929395
NCBI chr 7:131,100,684...131,138,250
Ensembl chr 7:129,221,653...129,259,192
G
Pkm
pyruvate kinase M1/2
decreases expression
ISO
bardoxolone methyl results in decreased expression of PKM protein
CTD
PMID:35929395
NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:60,057,402...60,079,599
G
Plau
plasminogen activator, urokinase
increases expression
ISO
bardoxolone methyl results in increased expression of PLAU mRNA
CTD
PMID:35724838
NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775
G
Pparg
peroxisome proliferator-activated receptor gamma
increases expression
ISO
bardoxolone methyl results in increased expression of PPARG mRNA; bardoxolone methyl results in increased expression of PPARG protein
CTD
PMID:21289052
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
G
Prkag2
protein kinase AMP-activated non-catalytic subunit gamma 2
affects expression
ISO
bardoxolone methyl affects the expression of PRKAG2 mRNA
CTD
PMID:35724838
NCBI chr 4:10,744,695...10,985,939
Ensembl chr 4:10,010,890...10,252,142
G
Ptpn1
protein tyrosine phosphatase, non-receptor type 1
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of PTPN1 protein]
CTD
PMID:27417254
NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:156,638,769...156,687,504
G
Rara
retinoic acid receptor, alpha
affects expression
ISO
bardoxolone methyl affects the expression of RARA mRNA
CTD
PMID:34480604
NCBI chr10:84,379,780...84,424,371
Ensembl chr10:83,893,384...83,928,142
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [IL1B protein affects the localization of RELA protein]; bardoxolone methyl inhibits the reaction [TNF protein affects the localization of RELA protein]
CTD
PMID:35724838
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
G
Rps6
ribosomal protein S6
multiple interactions decreases expression
ISO
bardoxolone methyl inhibits the reaction [INS protein results in increased phosphorylation of RPS6 protein] bardoxolone methyl results in decreased expression of RPS6 protein
CTD
PMID:28790194 PMID:35929395
NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
G
Rps6kb1
ribosomal protein S6 kinase B1
decreases phosphorylation
ISO
bardoxolone methyl results in decreased phosphorylation of RPS6KB1 protein
CTD
PMID:35929395
NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
G
Scarb1
scavenger receptor class B, member 1
affects expression
ISO
bardoxolone methyl affects the expression of SCARB1 mRNA
CTD
PMID:34480604
NCBI chr12:36,957,302...37,023,982
Ensembl chr12:31,296,156...31,362,647
G
Sh3bp5
SH3-domain binding protein 5
affects expression
ISO
bardoxolone methyl affects the expression of SH3BP5 mRNA
CTD
PMID:34480604
NCBI chr16:6,589,877...6,676,524
Ensembl chr16:6,583,465...6,698,975
G
Sigmar1
sigma non-opioid intracellular receptor 1
multiple interactions decreases expression
ISO
Ursolic Acid inhibits the reaction [bardoxolone methyl results in decreased expression of SIGMAR1 protein]
CTD
PMID:36587836
NCBI chr 5:61,700,021...61,702,799
Ensembl chr 5:56,904,159...56,907,017
G
Slc1a5
solute carrier family 1 member 5
decreases glycosylation decreases expression
ISO
bardoxolone methyl results in decreased glycosylation of SLC1A5 protein bardoxolone methyl results in decreased expression of SLC1A5 protein
CTD
PMID:35929395
NCBI chr 1:86,584,949...86,599,052
Ensembl chr 1:77,456,694...77,470,952
G
Slc3a2
solute carrier family 3 member 2
decreases expression
ISO
bardoxolone methyl results in decreased expression of SLC3A2 mRNA
CTD
PMID:35724838
NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:205,604,468...205,618,931
G
Slc47a1
solute carrier family 47 member 1
increases expression
ISO
bardoxolone methyl results in increased expression of SLC47A1 mRNA; bardoxolone methyl results in increased expression of SLC47A1 protein
CTD
PMID:27480280
NCBI chr10:46,533,580...46,590,128
Ensembl chr10:46,034,122...46,087,637
G
Socs3
suppressor of cytokine signaling 3
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]
CTD
PMID:26918785
NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787
G
Sqstm1
sequestosome 1
affects expression decreases expression
ISO
bardoxolone methyl affects the expression of SQSTM1 mRNA bardoxolone methyl results in decreased expression of SQSTM1 mRNA
CTD
PMID:34480604 PMID:35724838
NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673
G
Srxn1
sulfiredoxin 1
increases expression decreases expression multiple interactions
ISO
bardoxolone methyl results in increased expression of SRXN1 protein bardoxolone methyl results in decreased expression of SRXN1 mRNA bardoxolone methyl results in increased expression of SRXN1 mRNA; bardoxolone methyl results in increased expression of SRXN1 protein NFE2L2 promotes the reaction [bardoxolone methyl results in increased expression of SRXN1 protein]
CTD
PMID:27358234 PMID:34480604 PMID:35724838
NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:140,599,608...140,628,448
G
Stat3
signal transducer and activator of transcription 3
decreases phosphorylation multiple interactions
ISO
bardoxolone methyl results in decreased phosphorylation of STAT3 protein [bardoxolone methyl co-treated with Dietary Fats] results in decreased expression of STAT3 protein; bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of STAT3 protein]
CTD
PMID:17363558 PMID:25637688 PMID:27417254
NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
G
Tacr1
tachykinin receptor 1
decreases activity
ISO
bardoxolone methyl results in decreased activity of TACR1 protein
CTD
PMID:28790194
NCBI chr 4:116,478,617...116,647,492
Ensembl chr 4:114,920,844...115,089,733
G
Tap1
transporter 1, ATP binding cassette subfamily B member
increases expression
ISO
bardoxolone methyl results in increased expression of TAP1 mRNA
CTD
PMID:35724838
NCBI chr20:4,658,171...4,668,543
Ensembl chr20:4,656,263...4,666,901
G
Th
tyrosine hydroxylase
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased phosphorylation of TH protein]
CTD
PMID:25637688
NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
G
Thrsp
thyroid hormone responsive
decreases expression
ISO
bardoxolone methyl results in decreased expression of THRSP mRNA
CTD
PMID:20372807
NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:151,723,086...151,728,075
G
Tnf
tumor necrosis factor
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [TNF protein affects the localization of NFKBIA protein]; bardoxolone methyl inhibits the reaction [TNF protein affects the localization of RELA protein]; bardoxolone methyl inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; bardoxolone methyl inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]; bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] [bardoxolone methyl co-treated with Dietary Fats] results in decreased expression of TNF protein; bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of TNF]; bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD
PMID:25637688 PMID:26612656 PMID:26918785 PMID:27417254 PMID:35724838
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Tnfaip3
TNF alpha induced protein 3
increases expression multiple interactions
ISO
bardoxolone methyl results in increased expression of TNFAIP3 mRNA; bardoxolone methyl results in increased expression of TNFAIP3 protein bardoxolone methyl inhibits the reaction [IL1B protein results in increased expression of TNFAIP3 protein]; bardoxolone methyl inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]
CTD
PMID:35724838
NCBI chr 1:15,528,921...15,543,993
Ensembl chr 1:13,709,206...13,725,282
G
Tnfrsf9
TNF receptor superfamily member 9
increases expression
ISO
bardoxolone methyl results in increased expression of TNFRSF9 mRNA
CTD
PMID:35724838
NCBI chr 5:166,664,494...166,690,834
Ensembl chr 5:161,381,662...161,408,000
G
Trib3
tribbles pseudokinase 3
decreases expression
ISO
bardoxolone methyl results in decreased expression of TRIB3 mRNA
CTD
PMID:35724838
NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:140,809,043...140,814,497
G
Txnrd1
thioredoxin reductase 1
increases expression decreases expression
ISO
bardoxolone methyl results in increased expression of TXNRD1 mRNA bardoxolone methyl results in decreased expression of TXNRD1 mRNA
CTD
PMID:34480604 PMID:35724838
NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863
G
Ucp2
uncoupling protein 2
multiple interactions
ISO
bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased expression of UCP2 protein]
CTD
PMID:25637688
NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611
G
Vcam1
vascular cell adhesion molecule 1
increases expression
ISO
bardoxolone methyl results in increased expression of VCAM1 mRNA
CTD
PMID:35724838
NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958
G
Vegfa
vascular endothelial growth factor A
multiple interactions decreases expression
ISO
bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of VEGFA protein]; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA] bardoxolone methyl results in decreased expression of VEGFA mRNA
CTD
PMID:26918785 PMID:35724838
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
G
Zfand2a
zinc finger AN1-type containing 2A
affects expression decreases expression
ISO
bardoxolone methyl affects the expression of ZFAND2A mRNA bardoxolone methyl results in decreased expression of ZFAND2A mRNA
CTD
PMID:34480604 PMID:35724838
NCBI chr12:20,275,435...20,286,513
Ensembl chr12:15,161,639...15,172,677
G
Calml5
calmodulin-like 5
increases expression
ISO
beta-damascenone results in increased expression of CALM4 mRNA
CTD
PMID:22982537
NCBI chr17:71,304,326...71,305,245
G
Casp14
caspase 14
increases expression affects localization
ISO
beta-damascenone results in increased expression of CASP14 mRNA beta-damascenone affects the localization of CASP14 protein
CTD
PMID:22982537
NCBI chr 7:11,577,315...11,583,987
Ensembl chr 7:10,926,725...10,933,405
G
Ces3a
carboxylesterase 3a
increases expression
ISO
beta-damascenone results in increased expression of CES3 mRNA
CTD
PMID:22982537
NCBI chr19:49,902,312...49,910,484
G
Clca1
chloride channel accessory 1
increases expression
ISO
beta-damascenone results in increased expression of CLCA1 mRNA
CTD
PMID:22982537
NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369
G
Clca2
chloride channel accessory 2
increases expression
ISO
beta-damascenone results in increased expression of CLCA2 mRNA
CTD
PMID:22982537
NCBI chr 2:233,993,619...234,022,691
Ensembl chr 2:233,995,078...234,022,199
G
Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
increases expression
ISO
beta-damascenone results in increased expression of CYP17A1 mRNA
CTD
PMID:22982537
NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
G
Fcgbp
Fc gamma binding protein
increases expression
ISO
beta-damascenone results in increased expression of FCGBP mRNA
CTD
PMID:22982537
NCBI chr 1:92,502,461...92,540,658
Ensembl chr 1:83,372,127...83,413,083
G
Flg
filaggrin
increases expression
ISO
beta-damascenone results in increased expression of FLG mRNA; beta-damascenone results in increased expression of FLG protein
CTD
PMID:22982537
NCBI chr 2:181,583,801...181,596,464
G
Hrnr
hornerin
increases expression
ISO
beta-damascenone results in increased expression of HRNR mRNA
CTD
PMID:22982537
NCBI chr 2:181,650,772...181,663,633
G
Il20ra
interleukin 20 receptor subunit alpha
increases expression
ISO
beta-damascenone results in increased expression of IL20RA mRNA
CTD
PMID:22982537
NCBI chr 1:16,243,683...16,313,229
Ensembl chr 1:14,451,228...14,493,602
G
Il36rn
interleukin 36 receptor antagonist
increases expression
ISO
beta-damascenone results in increased expression of IL36RN mRNA
CTD
PMID:22982537
NCBI chr 3:27,442,679...27,449,306
Ensembl chr 3:7,044,406...7,051,016
G
Krt1
keratin 1
increases expression
ISO
beta-damascenone results in increased expression of KRT1 mRNA
CTD
PMID:22982537
NCBI chr 7:134,855,311...134,860,537
Ensembl chr 7:132,976,620...132,981,844
G
Krt10
keratin 10
increases expression
ISO
beta-damascenone results in increased expression of KRT10 mRNA
CTD
PMID:22982537
NCBI chr10:84,834,865...84,839,160
Ensembl chr10:84,338,706...84,343,701
G
Lce1b
late cornified envelope 1B
increases expression
ISO
beta-damascenone results in increased expression of LCE1B mRNA
CTD
PMID:22982537
NCBI chr 2:180,951,824...180,953,140
Ensembl chr 2:178,256,213...178,257,985
G
Lce1f
late cornified envelope 1F
increases expression
ISO
beta-damascenone results in increased expression of LCE1F mRNA
CTD
PMID:22982537
NCBI chr 2:181,001,399...181,002,985
Ensembl chr 2:178,305,786...178,307,372
G
Lipm
lipase, family member M
increases expression
ISO
beta-damascenone results in increased expression of LIPM mRNA
CTD
PMID:22982537
NCBI chr 1:241,031,382...241,050,796
Ensembl chr 1:231,618,284...231,637,410
G
Loricrin
loricrin cornified envelope precursor protein
increases expression
ISO
beta-damascenone results in increased expression of LORICRIN mRNA
CTD
PMID:22982537
NCBI chr 2:180,253,674...180,256,572
Ensembl chr 2:177,558,252...177,559,807
G
Otop3
otopetrin 3
increases expression
ISO
beta-damascenone results in increased expression of OTOP3 mRNA
CTD
PMID:22982537
NCBI chr10:100,577,346...100,588,729
Ensembl chr10:100,577,392...100,588,726
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Pla2g4f
phospholipase A2, group IVF
increases expression
ISO
beta-damascenone results in increased expression of PLA2G4F mRNA
CTD
PMID:22982537
NCBI chr 3:127,702,603...127,720,429
Ensembl chr 3:107,250,075...107,264,689
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Plcxd1
phosphatidylinositol-specific phospholipase C, X domain containing 1
increases expression
ISO
beta-damascenone results in increased expression of PLCXD1 mRNA
CTD
PMID:22982537
NCBI chr12:52,238,450...52,241,884
Ensembl chr12:46,579,225...46,582,392
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Sdr16c5
short chain dehydrogenase/reductase family 16C, member 5
increases expression
ISO
beta-damascenone results in increased expression of SDR16C5 mRNA
CTD
PMID:22982537
NCBI chr 5:21,816,394...21,841,596
Ensembl chr 5:17,018,813...17,040,970
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Susd2
sushi domain containing 2
increases expression
ISO
beta-damascenone results in increased expression of SUSD2 mRNA
CTD
PMID:22982537
NCBI chr20:13,016,960...13,024,264
Ensembl chr20:13,017,477...13,024,903
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Tmprss4
transmembrane serine protease 4
increases expression
ISO
beta-damascenone results in increased expression of TMPRSS4 mRNA
CTD
PMID:22982537
NCBI chr 8:54,372,805...54,405,157
Ensembl chr 8:45,476,053...45,508,409
G
Abca1
ATP binding cassette subfamily A member 1
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of ABCA1 mRNA
CTD
PMID:25270620
NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170
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Abcb11
ATP binding cassette subfamily B member 11
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of ABCB11 mRNA
CTD
PMID:28392238
NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730
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Abcc2
ATP binding cassette subfamily C member 2
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of ABCC2 mRNA
CTD
PMID:28392238
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
G
Abcc3
ATP binding cassette subfamily C member 3
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of ABCC3 mRNA
CTD
PMID:28392238
NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595
G
Abcg1
ATP binding cassette subfamily G member 1
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of ABCG1 mRNA
CTD
PMID:25270620
NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,126,687...9,182,948
G
Abcg8
ATP binding cassette subfamily G member 8
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of ABCG8 mRNA; beta-hexachlorocyclohexane results in increased expression of ABCG8 protein
CTD
PMID:27203212
NCBI chr 6:15,698,448...15,717,730
Ensembl chr 6:9,945,629...9,964,912
G
Abl1
ABL proto-oncogene 1, non-receptor tyrosine kinase
increases methylation
ISO
beta-hexachlorocyclohexane results in increased methylation of ABL1 promoter
CTD
PMID:35788154
NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065
G
Acadl
acyl-CoA dehydrogenase, long chain
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of ACADL mRNA; beta-hexachlorocyclohexane results in decreased expression of ACADL protein
CTD
PMID:28397872
NCBI chr 9:75,783,689...75,822,077
Ensembl chr 9:68,333,980...68,372,220
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Acadm
acyl-CoA dehydrogenase medium chain
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of ACADM mRNA; beta-hexachlorocyclohexane results in decreased expression of ACADM protein
CTD
PMID:28397872
NCBI chr 2:245,518,693...245,542,864
Ensembl chr 2:242,858,865...242,883,147
G
Acads
acyl-CoA dehydrogenase short chain
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of ACADS mRNA; beta-hexachlorocyclohexane results in decreased expression of ACADS protein
CTD
PMID:28397872
NCBI chr12:47,154,259...47,163,580
Ensembl chr12:41,493,626...41,502,898
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Acox1
acyl-CoA oxidase 1
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of ACOX1 mRNA
CTD
PMID:28397872
NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,406,197...101,431,232
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Adipoq
adiponectin, C1Q and collagen domain containing
affects response to substance multiple interactions
ISO
ADIPOQ gene SNP affects the susceptibility to beta-hexachlorocyclohexane [ADIPOQ gene SNP affects the susceptibility to beta-hexachlorocyclohexane] which affects the expression of ADIPOQ protein
CTD
PMID:27883041
NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564
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Agtr1a
angiotensin II receptor, type 1a
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of AGTR1A mRNA
CTD
PMID:25270620
NCBI chr17:34,383,397...34,435,523
Ensembl chr17:34,174,429...34,226,946
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Ahr
aryl hydrocarbon receptor
affects expression multiple interactions
ISO
beta-hexachlorocyclohexane affects the expression of AHR protein 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide affects the reaction [beta-hexachlorocyclohexane affects the expression of AHR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [beta-hexachlorocyclohexane affects the expression of AHR protein]
CTD
PMID:33207735
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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Akap13
A-kinase anchoring protein 13
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of AKAP13 mRNA
CTD
PMID:25270620
NCBI chr 1:138,722,445...139,029,401
Ensembl chr 1:129,314,402...129,619,646
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Alas1
5'-aminolevulinate synthase 1
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of ALAS1 mRNA
CTD
PMID:25270620
NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:106,876,514...106,889,917
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Alg5
ALG5, dolichyl-phosphate beta-glucosyltransferase
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of ALG5 mRNA
CTD
PMID:25270620
NCBI chr 2:141,087,126...141,101,397
Ensembl chr 2:138,936,993...138,951,216
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Ank1
ankyrin 1
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of ANK1 mRNA
CTD
PMID:25270620
NCBI chr16:75,578,824...75,757,464
Ensembl chr16:68,877,504...69,054,759
G
Apoa5
apolipoprotein A5
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of APOA5 mRNA
CTD
PMID:25270620
NCBI chr 8:55,446,329...55,460,509
Ensembl chr 8:46,561,229...46,563,816
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Ar
androgen receptor
multiple interactions affects expression
ISO
beta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; bicalutamide affects the reaction [beta-hexachlorocyclohexane affects the expression of AR protein]
CTD
PMID:26022396 PMID:33207735
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925
G
Atp11b
ATPase phospholipid transporting 11B (putative)
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of ATP11B mRNA
CTD
PMID:25270620
NCBI chr 2:118,585,348...118,691,076
Ensembl chr 2:118,585,342...118,690,232
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Atp7b
ATPase copper transporting beta
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of ATP7B mRNA
CTD
PMID:25270620
NCBI chr16:76,654,725...76,726,092
Ensembl chr16:69,951,778...70,023,636
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Bcr
BCR activator of RhoGEF and GTPase
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of BCR mRNA
CTD
PMID:25270620
NCBI chr20:13,468,732...13,596,333
Ensembl chr20:13,471,668...13,597,016
G
Brca1
BRCA1, DNA repair associated
multiple interactions increases expression
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA]; fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA]
CTD
PMID:20206645
NCBI chr10:86,917,693...86,978,012
Ensembl chr10:86,418,000...86,477,304
G
Casp3
caspase 3
increases cleavage
EXP
beta-hexachlorocyclohexane results in increased cleavage of CASP3 protein
CTD
PMID:19760616
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
increases cleavage
EXP
beta-hexachlorocyclohexane results in increased cleavage of CASP8 protein
CTD
PMID:19760616
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
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Cat
catalase
multiple interactions
EXP
[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of CAT protein
CTD
PMID:16046044
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
G
Ccdc63
coiled-coil domain containing 63
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of CCDC63 mRNA
CTD
PMID:25270620
NCBI chr12:40,085,146...40,113,820
Ensembl chr12:34,424,344...34,453,085
G
Ccnd1
cyclin D1
increases expression multiple interactions
ISO
beta-hexachlorocyclohexane results in increased expression of CCND1 mRNA fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of CCND1 mRNA]
CTD
PMID:17640349 PMID:20206645
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
G
Cd19
CD19 molecule
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of CD19 mRNA
CTD
PMID:25270620
NCBI chr 1:190,417,853...190,424,494
Ensembl chr 1:180,987,286...180,993,975
G
Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of CDKN1B mRNA
CTD
PMID:17640349
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
G
Cers6
ceramide synthase 6
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of CERS6 mRNA
CTD
PMID:25270620
NCBI chr 3:74,038,520...74,287,544
Ensembl chr 3:53,630,959...53,876,848
G
Ces1d
carboxylesterase 1D
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of CES1D mRNA
CTD
PMID:25270620
NCBI chr19:30,046,494...30,085,039
Ensembl chr19:13,796,623...13,912,035
G
Cops8
COP9 signalosome subunit 8
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of COPS8 mRNA
CTD
PMID:25270620
NCBI chr 9:98,655,031...98,664,861
Ensembl chr 9:91,207,395...91,217,258
G
Cpt1a
carnitine palmitoyltransferase 1A
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of CPT1A mRNA
CTD
PMID:25270620 PMID:28397872
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055
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Ctss
cathepsin S
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of CTSS mRNA
CTD
PMID:25270620
NCBI chr 2:185,775,316...185,803,440
Ensembl chr 2:183,086,437...183,114,483
G
Cyp27a1
cytochrome P450, family 27, subfamily a, polypeptide 1
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of CYP27A1 mRNA
CTD
PMID:28392238
NCBI chr 9:83,712,402...83,743,222
Ensembl chr 9:76,264,860...76,294,551
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of CYP2B10 mRNA
CTD
PMID:25270620
NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
G
Cyp2c24
cytochrome P450, family 2, subfamily c, polypeptide 24
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of CYP2C55 mRNA
CTD
PMID:25270620
NCBI chr 1:246,286,341...246,348,607
Ensembl chr 1:236,873,967...236,936,238
G
Cyp2c6
cytochrome P450, family 2, subfamily C, polypeptide 6
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of CYP2C29 mRNA
CTD
PMID:25270620
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of CYP7A1 mRNA
CTD
PMID:28392238
NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:19,376,974...19,386,688
G
Cyp8b1
cytochrome P450 family 8 subfamily B member 1
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of CYP8B1 mRNA
CTD
PMID:28392238
NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:121,557,062...121,580,166
G
Dab1
DAB adaptor protein 1
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of DAB1 mRNA
CTD
PMID:25270620
NCBI chr 5:123,621,510...124,742,585
Ensembl chr 5:119,140,533...119,510,552
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Defa5
defensin alpha 5
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of DEFA5 mRNA
CTD
PMID:25270620
NCBI chr16:77,044,994...77,047,318
Ensembl chr16:70,342,530...70,344,836
G
Drd2
dopamine receptor D2
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of DRD2 mRNA
CTD
PMID:25270620
NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875
G
Dtl
denticleless E3 ubiquitin protein ligase homolog
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of DTL mRNA
CTD
PMID:25270620
NCBI chr13:105,646,908...105,685,921
Ensembl chr13:103,117,186...103,154,890
G
Dync2i1
dynein 2 intermediate chain 1
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of DYNC2I1 mRNA
CTD
PMID:25270620
NCBI chr 6:143,276,441...143,333,006
Ensembl chr 6:137,133,418...137,188,719
G
Eif2b3
eukaryotic translation initiation factor 2B subunit gamma
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of EIF2B3 mRNA
CTD
PMID:25270620
NCBI chr 5:135,728,764...135,795,276
Ensembl chr 5:130,492,220...130,563,332
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Emp2
epithelial membrane protein 2
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of EMP2 mRNA
CTD
PMID:25270620
NCBI chr10:5,866,869...5,901,533
Ensembl chr10:5,360,073...5,394,733
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Epb41
erythrocyte membrane protein band 4.1
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of EPB41 mRNA
CTD
PMID:25270620
NCBI chr 5:149,394,080...149,548,178
Ensembl chr 5:144,111,906...144,237,821
G
Erbb2
erb-b2 receptor tyrosine kinase 2
increases expression multiple interactions increases activity
ISO
beta-hexachlorocyclohexane results in increased expression of ERBB2 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; afimoxifene inhibits the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein] beta-hexachlorocyclohexane results in increased activity of ERBB2 protein beta-hexachlorocyclohexane results in increased expression of ERBB2 protein
CTD
PMID:9443065 PMID:11222871 PMID:12439862 PMID:12948864 PMID:17640349
NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078
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Erbb3
erb-b2 receptor tyrosine kinase 3
multiple interactions
ISO
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; afimoxifene inhibits the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]
CTD
PMID:12439862
NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:996,225...1,015,525
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Ermp1
endoplasmic reticulum metallopeptidase 1
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of ERMP1 mRNA
CTD
PMID:25270620
NCBI chr 1:236,801,459...236,835,656
Ensembl chr 1:227,387,920...227,436,909
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Esr1
estrogen receptor 1
decreases expression increases expression multiple interactions increases activity
ISO
beta-hexachlorocyclohexane results in decreased expression of ESR1 mRNA; beta-hexachlorocyclohexane results in decreased expression of ESR1 protein beta-hexachlorocyclohexane results in increased expression of ESR1 mRNA 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in decreased expression of ESR1 mRNA]; fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in decreased expression of ESR1 mRNA] beta-hexachlorocyclohexane results in increased expression of ESR1 protein beta-hexachlorocyclohexane results in increased activity of ESR1 protein [Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in increased expression of ESR1 mRNA; beta-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein]
CTD
PMID:12948864 PMID:15064155 PMID:15541753 PMID:16758953 PMID:20206645 PMID:21278053 PMID:21295777 PMID:26022396 More...
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
multiple interactions increases activity
ISO
beta-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR2 protein] beta-hexachlorocyclohexane results in increased activity of ESR2 protein
CTD
PMID:15064155 PMID:21278053
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919
G
Etv1
ETS variant transcription factor 1
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of ETV1 mRNA
CTD
PMID:25270620
NCBI chr 6:61,316,836...61,408,985
Ensembl chr 6:55,590,234...55,681,775
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Exosc8
exosome component 8
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of EXOSC8 mRNA
CTD
PMID:25270620
NCBI chr 2:141,080,568...141,087,112
Ensembl chr 2:138,930,405...138,936,928
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Fabp5
fatty acid binding protein 5
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of FABP5 mRNA
CTD
PMID:28392238
NCBI chr 2:93,672,451...93,676,186
Ensembl chr 2:91,765,056...91,853,773
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Fam107a
family with sequence similarity 107, member A
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of FAM107A mRNA
CTD
PMID:25270620
NCBI chr15:19,038,726...19,060,644
Ensembl chr15:16,607,205...16,630,396
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Faslg
Fas ligand
multiple interactions increases expression
EXP
Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of FASLG protein]
CTD
PMID:19760616
NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
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Fasn
fatty acid synthase
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of FASN protein
CTD
PMID:27203212 PMID:28397872
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
G
Fgf19
fibroblast growth factor 19
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of FGF15 mRNA
CTD
PMID:28392238
NCBI chr 1:209,485,813...209,490,267
Ensembl chr 1:200,056,644...200,060,287
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G6pd
glucose-6-phosphate dehydrogenase
increases activity
EXP
beta-hexachlorocyclohexane results in increased activity of G6PD protein
CTD
PMID:2461408
NCBI chr X:157,352,364...157,372,144
Ensembl chr X:152,201,098...152,220,801
G
Gnrh1
gonadotropin releasing hormone 1
multiple interactions
ISO
[Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in increased expression of GNRH1 mRNA
CTD
PMID:16758953
NCBI chr15:46,147,878...46,152,086
Ensembl chr15:41,972,905...41,973,581 Ensembl chr15:41,972,905...41,973,581
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Gpr146
G protein-coupled receptor 146
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of GPR146 mRNA
CTD
PMID:25270620
NCBI chr12:20,365,790...20,381,122
Ensembl chr12:15,251,813...15,267,206
G
Gsr
glutathione-disulfide reductase
multiple interactions
EXP
[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of GSR protein
CTD
PMID:16046044
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
G
Gstm1
glutathione S-transferase mu 1
affects response to substance
ISO
GSTM1 gene polymorphism affects the susceptibility to beta-hexachlorocyclohexane
CTD
PMID:22310945
NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411
G
H2ax
H2A.X variant histone
increases phosphorylation
ISO
beta-hexachlorocyclohexane results in increased phosphorylation of H2AX protein
CTD
PMID:33207735
NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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Hmox1
heme oxygenase 1
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of HMOX1 mRNA
CTD
PMID:25270620
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
G
Hyal1
hyaluronidase 1
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of HYAL1 mRNA
CTD
PMID:25270620
NCBI chr 8:117,129,311...117,133,162
Ensembl chr 8:108,250,667...108,260,210
G
Igf1r
insulin-like growth factor 1 receptor
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of IGF1R mRNA
CTD
PMID:17640349
NCBI chr 1:130,959,787...131,248,664
Ensembl chr 1:121,550,743...121,831,777
G
Igsf3
immunoglobulin superfamily, member 3
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of IGSF3 mRNA
CTD
PMID:25270620
NCBI chr 2:188,811,394...188,899,645
Ensembl chr 2:188,811,380...188,899,645
G
Ins1
insulin 1
decreases secretion
EXP
beta-hexachlorocyclohexane results in decreased secretion of INS1 protein
CTD
PMID:31923579
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
G
Jmjd6
jumonji domain containing 6, arginine demethylase and lysine hydroxylase
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of JMJD6 mRNA
CTD
PMID:25270620
NCBI chr10:102,539,935...102,545,986
Ensembl chr10:102,041,120...102,047,182
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions increases expression
EXP
[beta-hexachlorocyclohexane co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of JUN mRNA beta-hexachlorocyclohexane results in increased expression of JUN mRNA
CTD
PMID:18481421
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
G
Kank3
KN motif and ankyrin repeat domains 3
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of KANK3 mRNA
CTD
PMID:25270620
NCBI chr 7:15,296,538...15,309,838
Ensembl chr 7:14,594,422...14,607,675
G
Kcnd2
potassium voltage-gated channel subfamily D member 2
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of KCND2 mRNA
CTD
PMID:25270620
NCBI chr 4:50,741,595...51,243,540
Ensembl chr 4:49,776,246...50,277,728
G
Kdelr2
KDEL endoplasmic reticulum protein retention receptor 2
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of KDELR2 mRNA
CTD
PMID:25270620
NCBI chr12:16,252,424...16,270,737
Ensembl chr12:11,138,820...11,157,153
G
Kif24
kinesin family member 24
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of KIF24 mRNA
CTD
PMID:25270620
NCBI chr 5:61,357,078...61,423,882
Ensembl chr 5:56,561,154...56,628,025
G
Klk1c10
kallikrein 1-related peptidase C10
increases expression multiple interactions
ISO
beta-hexachlorocyclohexane results in increased expression of KLK3 mRNA bicalutamide inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of KLK3 mRNA]
CTD
PMID:33207735
NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:94,402,993...94,407,052
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Krt19
keratin 19
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of KRT19 mRNA
CTD
PMID:17640349
NCBI chr10:85,576,235...85,580,952
Ensembl chr10:85,066,802...85,171,799
G
Lcn8
lipocalin 8
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of LCN8 mRNA
CTD
PMID:25270620
NCBI chr 3:28,866,061...28,869,045
Ensembl chr 3:8,467,934...8,470,918
G
Mapk1
mitogen activated protein kinase 1
decreases expression multiple interactions
ISO
beta-hexachlorocyclohexane results in decreased expression of MAPK1 protein beta-hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK1 protein
CTD
PMID:12948864 PMID:20206645
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
decreases expression multiple interactions
ISO
beta-hexachlorocyclohexane results in decreased expression of MAPK3 protein beta-hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK3 protein
CTD
PMID:12948864 PMID:20206645
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
G
Mapk8
mitogen-activated protein kinase 8
multiple interactions increases phosphorylation
EXP
Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane results in increased phosphorylation of MAPK8 protein]
CTD
PMID:19760616
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
G
Mapk9
mitogen-activated protein kinase 9
multiple interactions increases phosphorylation
EXP
Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane results in increased phosphorylation of MAPK9 protein]
CTD
PMID:19760616
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178
G
Mgme1
mitochondrial genome maintenance exonuclease 1
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of MGME1 mRNA
CTD
PMID:25270620
NCBI chr 3:152,094,514...152,103,314
Ensembl chr 3:131,640,944...131,649,932
G
Mmp12
matrix metallopeptidase 12
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of MMP12 mRNA
CTD
PMID:17640349
NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:4,581,785...4,599,611
G
Mmp13
matrix metallopeptidase 13
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of MMP13 mRNA
CTD
PMID:17640349
NCBI chr 8:12,782,829...12,793,108
Ensembl chr 8:4,497,960...4,508,239
G
Mmp9
matrix metallopeptidase 9
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of MMP9 protein
CTD
PMID:12948864
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
G
Mroh9
maestro heat-like repeat family member 9
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of MROH9 mRNA
CTD
PMID:25270620
NCBI chr13:77,921,039...77,976,343
Ensembl chr13:75,387,746...75,443,092
G
Mylip
myosin regulatory light chain interacting protein
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of MYLIP mRNA
CTD
PMID:25270620
NCBI chr17:19,492,826...19,514,490
Ensembl chr17:19,286,650...19,308,295
G
Myo1e
myosin IE
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of MYO1E mRNA
CTD
PMID:25270620
NCBI chr 8:79,768,828...79,961,048
Ensembl chr 8:70,887,870...71,080,169
G
Nadk
NAD kinase
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of NADK mRNA
CTD
PMID:25270620
NCBI chr 5:171,427,973...171,458,586
Ensembl chr 5:166,145,481...166,176,322
G
Nr1h4
nuclear receptor subfamily 1, group H, member 4
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of NR1H4 mRNA
CTD
PMID:28392238
NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:23,846,122...23,942,047
G
Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
beta-hexachlorocyclohexane binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
G
Nr2c1
nuclear receptor subfamily 2, group C, member 1
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of NR2C1 mRNA
CTD
PMID:25270620
NCBI chr 7:30,602,338...30,655,610
Ensembl chr 7:28,715,562...28,767,160
G
Ntsr2
neurotensin receptor 2
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of NTSR2 mRNA
CTD
PMID:25270620
NCBI chr 6:45,153,095...45,159,783
Ensembl chr 6:39,424,324...39,431,014
G
Pdgfrb
platelet derived growth factor receptor beta
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of PDGFRB mRNA
CTD
PMID:25270620
NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843
G
Pfkfb1
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of PFKFB1 mRNA
CTD
PMID:25270620
NCBI chr X:22,936,038...22,989,691
Ensembl chr X:19,508,546...19,562,182
G
Pgr
progesterone receptor
multiple interactions increases expression
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA]; beta-hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]; fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA]; ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA] beta-hexachlorocyclohexane results in increased expression of PGR; beta-hexachlorocyclohexane results in increased expression of PGR mRNA
CTD
PMID:2479123 PMID:16242299 PMID:20206645 PMID:26022396
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
G
Pla2g12a
phospholipase A2, group XIIA
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of PLA2G12A mRNA
CTD
PMID:25270620
NCBI chr 2:221,110,722...221,126,966
Ensembl chr 2:218,436,513...218,452,740
G
Pla2g15
phospholipase A2, group XV
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of PLA2G15 mRNA
CTD
PMID:25270620
NCBI chr19:50,960,568...50,977,948
Ensembl chr19:34,050,694...34,068,063
G
Polr1b
RNA polymerase I subunit B
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of POLR1B mRNA
CTD
PMID:25270620
NCBI chr 3:136,787,130...136,811,608
Ensembl chr 3:116,333,889...116,358,379
G
Pomc
proopiomelanocortin
multiple interactions
ISO
[Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in decreased expression of POMC mRNA
CTD
PMID:16758953
NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664
G
Por
cytochrome p450 oxidoreductase
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of POR mRNA
CTD
PMID:25270620
NCBI chr12:26,587,674...26,655,612
Ensembl chr12:20,951,058...20,999,245
G
Prl
prolactin
increases expression multiple interactions
ISO
beta-hexachlorocyclohexane results in increased expression of PRL mRNA ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PRL mRNA]
CTD
PMID:8968093
NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062
G
Prpf18
pre-mRNA processing factor 18
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of PRPF18 mRNA
CTD
PMID:25270620
NCBI chr17:78,539,004...78,570,483
Ensembl chr17:73,630,571...73,690,979
G
Psmd12
proteasome 26S subunit, non-ATPase 12
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of PSMD12 mRNA
CTD
PMID:25270620
NCBI chr10:92,937,957...92,956,601
Ensembl chr10:92,438,298...92,457,287
G
Ptges
prostaglandin E synthase
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of PTGES mRNA
CTD
PMID:25270620
NCBI chr 3:34,575,643...34,586,987
G
Rdh9
retinol dehydrogenase 9
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of RDH9 mRNA
CTD
PMID:25270620
NCBI chr 7:65,527,552...65,530,396
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions affects localization
EXP
Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane affects the localization of RELA protein]
CTD
PMID:19760616
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
G
Rgs3
regulator of G-protein signaling 3
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of RGS3 mRNA
CTD
PMID:25270620
NCBI chr 5:81,037,588...81,177,446
Ensembl chr 5:76,022,001...76,161,894
G
Scd
stearoyl-CoA desaturase
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of SCD1 mRNA; beta-hexachlorocyclohexane results in increased expression of SCD1 protein
CTD
PMID:27203212 PMID:28397872
NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
G
Serpina7
serpin family A member 7
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of SERPINA7 protein
CTD
PMID:19750101
NCBI chr X:107,452,044...107,510,958
Ensembl chr X:102,663,405...102,669,040
G
Sh3d21
SH3 domain containing 21
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of SH3D21 mRNA
CTD
PMID:25270620
NCBI chr 5:143,713,718...143,729,073
Ensembl chr 5:138,429,180...138,444,407
G
Slc10a1
solute carrier family 10 member 1
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of SLC10A1 mRNA
CTD
PMID:28392238
NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:100,613,045...100,626,670
G
Slc10a2
solute carrier family 10 member 2
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of SLC10A2 mRNA
CTD
PMID:28392238
NCBI chr16:91,088,089...91,111,025
Ensembl chr16:84,374,862...84,409,475
G
Slc27a1
solute carrier family 27 member 1
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of SLC27A1 mRNA
CTD
PMID:25270620
NCBI chr16:18,311,859...18,337,024
Ensembl chr16:18,278,984...18,296,063
G
Slc29a1
solute carrier family 29 member 1
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of SLC29A1 mRNA
CTD
PMID:25270620
NCBI chr 9:22,897,099...22,911,640
Ensembl chr 9:15,399,612...15,414,203
G
Slc2a4
solute carrier family 2 member 4
decreases expression
EXP
beta-hexachlorocyclohexane results in decreased expression of SLC2A4 protein
CTD
PMID:31923579
NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565
G
Slc51a
solute carrier family 51 member A
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of SLC51A mRNA
CTD
PMID:28392238
NCBI chr11:81,804,141...81,818,539
Ensembl chr11:68,299,086...68,313,485
G
Slc51b
SLC51 subunit beta
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of SLC51B mRNA
CTD
PMID:28392238
NCBI chr 8:74,827,047...74,835,109
Ensembl chr 8:65,931,890...65,940,145
G
Sntb2
syntrophin, beta 2
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of SNTB2 mRNA
CTD
PMID:25270620
NCBI chr19:51,739,492...51,832,083
Ensembl chr19:34,831,584...34,914,113
G
Spag16
sperm associated antigen 16
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of SPAG16 mRNA
CTD
PMID:25270620
NCBI chr 9:78,782,596...79,702,265
Ensembl chr 9:71,332,992...72,252,708
G
Src
SRC proto-oncogene, non-receptor tyrosine kinase
multiple interactions
ISO
beta-hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of SRC protein
CTD
PMID:20206645
NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476
G
Srcap
Snf2-related CREBBP activator protein
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of SRCAP mRNA
CTD
PMID:25270620
NCBI chr 1:191,554,043...191,607,096
Ensembl chr 1:182,118,416...182,176,610
G
Srebf1
sterol regulatory element binding transcription factor 1
decreases expression increases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of SREBF1 mRNA beta-hexachlorocyclohexane results in increased expression of SREBF1 mRNA; beta-hexachlorocyclohexane results in increased expression of SREBF1 protein
CTD
PMID:25270620 PMID:27203212
NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650
G
Tacc1
transforming, acidic coiled-coil containing protein 1
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of TACC1 mRNA
CTD
PMID:25270620
NCBI chr16:73,515,016...73,598,395
Ensembl chr16:66,812,295...66,895,733
G
Tff1
trefoil factor 1
multiple interactions increases expression
ISO
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of TFF1 mRNA]
CTD
PMID:8968093 PMID:16242299 PMID:20206645
NCBI chr20:9,237,095...9,240,956
Ensembl chr20:9,235,736...9,239,597
G
Thumpd2
THUMP domain containing 2
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of THUMPD2 mRNA
CTD
PMID:25270620
NCBI chr 6:19,677,039...19,728,947
Ensembl chr 6:13,924,765...13,976,657
G
Tns1
tensin 1
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of TNS1 mRNA
CTD
PMID:25270620
NCBI chr 9:82,941,068...83,152,007
Ensembl chr 9:75,495,814...75,703,225
G
Tpm3
tropomyosin 3
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of TPM3 mRNA
CTD
PMID:25270620
NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:175,517,226...175,545,013
G
Trim42
tripartite motif-containing 42
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of TRIM42 mRNA
CTD
PMID:25270620
NCBI chr 8:106,781,847...106,802,764
Ensembl chr 8:97,902,353...97,923,268
G
Tshb
thyroid stimulating hormone subunit beta
multiple interactions
ISO
beta-hexachlorocyclohexane affects the expression of and affects the secretion of TSHB protein
CTD
PMID:19750101
NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:190,224,676...190,229,559
G
Tssc4
tumor suppressing subtransferable candidate 4
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of TSSC4 mRNA
CTD
PMID:25270620
NCBI chr 1:207,681,420...207,684,244
Ensembl chr 1:198,235,487...198,254,980
G
Ttc39b
tetratricopeptide repeat domain 39B
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of TTC39B mRNA
CTD
PMID:25270620
NCBI chr 5:102,649,259...102,754,092
Ensembl chr 5:97,609,392...97,736,270
G
Zfp113
zinc finger protein 3
increases expression
ISO
beta-hexachlorocyclohexane results in increased expression of ZFP113 mRNA
CTD
PMID:25270620
NCBI chr12:17,022,104...17,033,776
Ensembl chr12:17,022,279...17,033,709
G
Zfp597
zinc finger protein 597
decreases expression
ISO
beta-hexachlorocyclohexane results in decreased expression of ZFP597 mRNA
CTD
PMID:25270620
NCBI chr10:12,159,533...12,165,207
Ensembl chr10:11,653,127...11,660,675
G
Becn1
beclin 1
increases expression
ISO
beta-thujaplicin results in increased expression of BECN1 protein
CTD
PMID:25044443
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742
G
Mtor
mechanistic target of rapamycin kinase
decreases phosphorylation
ISO
beta-thujaplicin results in decreased phosphorylation of MTOR protein
CTD
PMID:25044443
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
G
Rps6kb1
ribosomal protein S6 kinase B1
decreases phosphorylation
ISO
beta-thujaplicin results in decreased phosphorylation of RPS6KB1 protein
CTD
PMID:25044443
NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
G
Sqstm1
sequestosome 1
decreases expression
ISO
beta-thujaplicin results in decreased expression of SQSTM1 protein
CTD
PMID:25044443
NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673
G
Acaca
acetyl-CoA carboxylase alpha
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of ACACA mRNA
CTD
PMID:38000518
NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,014,170...69,276,457
G
Acacb
acetyl-CoA carboxylase beta
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of ACACB mRNA
CTD
PMID:38000518
NCBI chr12:48,026,394...48,138,214
Ensembl chr12:42,366,548...42,457,655
G
Acly
ATP citrate lyase
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of ACLY mRNA
CTD
PMID:38000518
NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,412,049...85,463,320
G
Acta2
actin alpha 2, smooth muscle
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of ACTA2 mRNA
CTD
PMID:38000518
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
G
Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of AHR mRNA
CTD
PMID:38000518
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of AKT1 mRNA
CTD
PMID:38000518
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
G
Cat
catalase
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of CAT mRNA
CTD
PMID:38000518
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
G
Ccn2
cellular communication network factor 2
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of CTGF mRNA
CTD
PMID:38000518
NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734
G
Col1a1
collagen type I alpha 1 chain
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of COL1A1 mRNA
CTD
PMID:38000518
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
G
Col1a2
collagen type I alpha 2 chain
affects expression
ISO
Camphor analog affects the expression of COL1A2 mRNA
CTD
PMID:24704097
NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867
G
Cpt1a
carnitine palmitoyltransferase 1A
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of CPT1A mRNA
CTD
PMID:38000518
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055
G
Cpt2
carnitine palmitoyltransferase 2
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of CPT2 mRNA
CTD
PMID:38000518
NCBI chr 5:127,893,450...127,911,347
Ensembl chr 5:122,664,677...122,682,095
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of CYP1A1 mRNA
CTD
PMID:38000518
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
decreases activity
EXP
Camphor results in decreased activity of CYP2B1 protein
CTD
PMID:9242356
NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
G
Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
multiple interactions
ISO
Camphor inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion]
CTD
PMID:18611395
NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
G
Dgat1
diacylglycerol O-acyltransferase 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of DGAT1 mRNA
CTD
PMID:38000518
NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:108,218,524...108,234,299
G
Esr1
estrogen receptor 1
multiple interactions
ISO
Camphor binds to and results in increased activity of ESR1 protein
CTD
PMID:27633901
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
G
Fasn
fatty acid synthase
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of FASN mRNA
CTD
PMID:38000518
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
G
Foxo1
forkhead box O1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of FOXO1 mRNA
CTD
PMID:38000518
NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
G
Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
multiple interactions
ISO
Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:15588619
NCBI chr10:27,096,731...27,152,563
Ensembl chr10:26,595,160...26,650,864
G
Gabrb2
gamma-aminobutyric acid type A receptor subunit beta 2
multiple interactions
ISO
Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:15588619
NCBI chr10:27,438,127...27,657,680
Ensembl chr10:26,936,551...27,151,251
G
Gabrg2
gamma-aminobutyric acid type A receptor subunit gamma 2
multiple interactions
ISO
Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:15588619
NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,374,694...26,464,346
G
Gpx1
glutathione peroxidase 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of GPX1 mRNA
CTD
PMID:38000518
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
G
Gsr
glutathione-disulfide reductase
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of GSR mRNA
CTD
PMID:38000518
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
G
Mlycd
malonyl-CoA decarboxylase
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of MLYCD mRNA
CTD
PMID:38000518
NCBI chr19:64,356,582...64,372,447
Ensembl chr19:47,447,970...47,463,793
G
Mpo
myeloperoxidase
multiple interactions
ISO
Camphor inhibits the reaction [cinnamaldehyde results in increased activity of MPO protein]
CTD
PMID:21466812
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of NFE2L2 mRNA
CTD
PMID:38000518
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
G
Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of NFKB1 mRNA
CTD
PMID:38000518
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
G
Pgr
progesterone receptor
multiple interactions
ISO
Camphor binds to and results in decreased activity of PGR protein
CTD
PMID:27633901
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
G
Ppara
peroxisome proliferator activated receptor alpha
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of PPARA mRNA
CTD
PMID:38000518
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
G
Ptgs1
prostaglandin-endoperoxide synthase 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of PTGS1 mRNA
CTD
PMID:38000518
NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:19,584,015...19,605,586
G
Runx2
RUNX family transcription factor 2
affects expression
ISO
Camphor analog affects the expression of RUNX2 mRNA
CTD
PMID:24704097
NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167
G
Snai1
snail family transcriptional repressor 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of SNAI1 mRNA
CTD
PMID:38000518
NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969
G
Sod1
superoxide dismutase 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of SOD1 mRNA
CTD
PMID:38000518
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
G
Sparc
secreted protein acidic and cysteine rich
affects expression
ISO
Camphor analog affects the expression of SPARC mRNA
CTD
PMID:24704097
NCBI chr10:40,017,065...40,038,816
Ensembl chr10:39,516,406...39,538,396
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in decreased expression of TGFB1 mRNA
CTD
PMID:38000518
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
G
Trpv1
transient receptor potential cation channel, subfamily V, member 1
multiple interactions
EXP
Lidocaine promotes the reaction [Camphor results in increased activity of TRPV1 protein]
CTD
PMID:18172555
NCBI chr10:58,349,936...58,375,021
Ensembl chr10:57,851,428...57,876,513
G
Trpv3
transient receptor potential cation channel, subfamily V, member 3
increases activity multiple interactions
ISO
Camphor results in increased activity of TRPV3 protein isopentenyl pyrophosphate inhibits the reaction [Camphor results in increased activity of TRPV3 protein]
CTD
PMID:21353389
NCBI chr10:58,382,054...58,413,657
Ensembl chr10:57,883,546...57,913,296
G
Zeb1
zinc finger E-box binding homeobox 1
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of ZEB1 mRNA
CTD
PMID:38000518
NCBI chr17:56,644,397...56,811,155
Ensembl chr17:51,948,948...52,115,214
G
Zeb2
zinc finger E-box binding homeobox 2
multiple interactions
ISO
[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of ZEB2 mRNA
CTD
PMID:38000518
NCBI chr 3:49,624,028...49,754,323
Ensembl chr 3:29,218,301...29,345,157
G
Clec10a
C-type lectin domain containing 10A
multiple interactions
ISO
carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of CLEC10A mRNA]
CTD
PMID:37967808
NCBI chr10:55,374,914...55,379,110
Ensembl chr10:54,876,260...54,880,435
G
Il13
interleukin 13
multiple interactions
ISO
carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of CLEC10A mRNA]; carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of MRC1 mRNA]; carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased phosphorylation of STAT6 protein]
CTD
PMID:37967808
NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737
G
Il1b
interleukin 1 beta
multiple interactions
ISO
carveol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD
PMID:37967808
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
G
Il4
interleukin 4
multiple interactions
ISO
carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of CLEC10A mRNA]; carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of MRC1 mRNA]; carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased phosphorylation of STAT6 protein]
CTD
PMID:37967808
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
G
Il6
interleukin 6
multiple interactions
ISO
carveol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
CTD
PMID:37967808
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
G
Mrc1
mannose receptor, C type 1
multiple interactions
ISO
carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased expression of MRC1 mRNA]
CTD
PMID:37967808
NCBI chr17:82,157,725...82,239,411
Ensembl chr17:77,249,187...77,330,857
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
carveol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]
CTD
PMID:37967808
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
G
Rhob
ras homolog family member B
increases expression multiple interactions
ISO
carveol results in increased expression of RHOB protein Mevalonic Acid affects the reaction [carveol results in increased expression of RHOB protein]
CTD
PMID:12671036
NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:31,363,548...31,366,108
G
Stat6
signal transducer and activator of transcription 6
multiple interactions
ISO
carveol promotes the reaction [[IL4 protein co-treated with IL13 protein] results in increased phosphorylation of STAT6 protein]
CTD
PMID:37967808
NCBI chr 7:65,365,505...65,382,825
Ensembl chr 7:63,479,642...63,498,495
G
Tnf
tumor necrosis factor
multiple interactions
ISO
carveol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD
PMID:37967808
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Ugt2b15
UDP glucuronosyltransferase family 2 member B15
increases metabolic processing
EXP
UGT2B15 protein results in increased metabolism of carveol
CTD
PMID:7574722
NCBI chr14:21,122,866...21,138,450
Ensembl chr14:20,768,015...20,783,589
G
Gba1
glucosylceramidase beta 1
multiple interactions decreases activity
ISO EXP
[conduritol epoxide binds to and results in decreased activity of GBA1 protein] which results in increased expression of SNCA protein [conduritol epoxide binds to and results in decreased activity of GBA1 protein] which affects the localization of SNCA protein; [conduritol epoxide binds to and results in decreased activity of GBA1 protein] which results in increased expression of SNCA protein conduritol epoxide analog results in decreased activity of GBA1 protein
CTD
PMID:9101438 PMID:19576930
NCBI chr 2:176,902,141...176,916,015
Ensembl chr 2:174,609,403...174,618,263
G
Snca
synuclein alpha
multiple interactions
ISO
[conduritol epoxide binds to and results in decreased activity of GBA1 protein] which affects the localization of SNCA protein; [conduritol epoxide binds to and results in decreased activity of GBA1 protein] which results in increased expression of SNCA protein
CTD
PMID:19576930
NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262
G
Crh
corticotropin releasing hormone
decreases expression affects expression
EXP
Cyclohexane results in decreased expression of CRH mRNA Cyclohexane affects the expression of CRH protein
CTD
PMID:37944760
NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919
G
Trh
thyrotropin releasing hormone
decreases expression
EXP
Cyclohexane results in decreased expression of TRH mRNA; Cyclohexane results in decreased expression of TRH protein
CTD
PMID:37944760
NCBI chr 4:126,299,236...126,301,762
Ensembl chr 4:124,742,111...124,744,637
G
Tshb
thyroid stimulating hormone subunit beta
decreases expression
EXP
Cyclohexane results in decreased expression of TSHB protein
CTD
PMID:37944760
NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:190,224,676...190,229,559
G
Glud1
glutamate dehydrogenase 1
multiple interactions
ISO EXP
cyclohexanone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein]
CTD
PMID:2554539
NCBI chr16:9,646,569...9,680,215
Ensembl chr16:9,640,312...9,673,957
G
Pgr
progesterone receptor
multiple interactions
ISO
cyclohexanone binds to and results in decreased activity of PGR protein
CTD
PMID:27633901
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
G
Or5d18
olfactory receptor family 5 subfamily D member 18
multiple interactions
ISO
Cyclohexanones binds to and results in increased activity of OR5D18 protein
CTD
PMID:21142015
NCBI chr 3:93,972,754...93,973,695
Ensembl chr 3:73,516,364...73,519,858 Ensembl chr 3:73,516,364...73,519,858
G
Lta4h
leukotriene A4 hydrolase
multiple interactions
ISO
cyclohexene inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]; cyclohexene inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4]
CTD
PMID:2827578
NCBI chr 7:29,856,846...29,888,642
Ensembl chr 7:27,969,789...28,001,600
G
Akr1c1
aldo-keto reductase family 1, member C1
multiple interactions increases reduction
ISO
NADP promotes the reaction [AKR1C1 protein results in increased reduction of cyclopentanone]
CTD
PMID:23261716
NCBI chr17:70,720,397...70,747,285
Ensembl chr17:65,810,475...65,837,326
G
Akr1c2
aldo-keto reductase family 1, member C2
increases reduction multiple interactions
ISO
AKR1C2 protein results in increased reduction of cyclopentanone [AKR1C2 protein co-treated with NADP] results in increased reduction of cyclopentanone; NADP promotes the reaction [AKR1C2 protein results in increased reduction of cyclopentanone]; Ursodeoxycholic Acid inhibits the reaction [[AKR1C2 protein co-treated with NADP] results in increased reduction of cyclopentanone]
CTD
PMID:23261716
NCBI chr17:70,669,684...70,717,935
Ensembl chr17:65,759,788...65,775,764
G
Akr1c3
aldo-keto reductase family 1, member C3
multiple interactions increases reduction
ISO
[AKR1C3 protein co-treated with NADP] results in increased reduction of cyclopentanone; Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein co-treated with NADP] results in increased reduction of cyclopentanone]; NADP promotes the reaction [AKR1C3 protein results in increased reduction of cyclopentanone]
CTD
PMID:23261716
NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873
G
Ar
androgen receptor
multiple interactions
ISO
delta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; delta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
CTD
PMID:10696776 PMID:26022396
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925
G
Casp3
caspase 3
increases activity
ISO
delta-hexachlorocyclohexane results in increased activity of CASP3 protein
CTD
PMID:19818741
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
G
Cat
catalase
multiple interactions
EXP
[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of CAT protein
CTD
PMID:16046044
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
G
Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
decreases activity multiple interactions
ISO
delta-hexachlorocyclohexane results in decreased activity of CDIPT protein [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; delta-hexachlorocyclohexane inhibits the reaction [CDIPT protein results in increased chemical synthesis of Cytidine Diphosphate Diglycerides]
CTD
PMID:2579070
NCBI chr 1:191,013,632...191,017,943
Ensembl chr 1:181,583,141...181,587,408
G
Esr1
estrogen receptor 1
increases activity
ISO
delta-hexachlorocyclohexane results in increased activity of ESR1 protein
CTD
PMID:15064155 PMID:26022396
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
increases activity
ISO
delta-hexachlorocyclohexane results in increased activity of ESR2 protein
CTD
PMID:15064155
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions decreases expression
EXP
delta-hexachlorocyclohexane inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS protein]; delta-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; delta-hexachlorocyclohexane inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein] delta-hexachlorocyclohexane results in decreased expression of FOS mRNA; delta-hexachlorocyclohexane results in decreased expression of FOS protein
CTD
PMID:1380685 PMID:7534335
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
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Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
multiple interactions
ISO
[delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; [delta-hexachlorocyclohexane co-treated with loreclezole] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]
CTD
PMID:9316872 PMID:11156579
NCBI chr10:27,096,731...27,152,563
Ensembl chr10:26,595,160...26,650,864
G
Gabra4
gamma-aminobutyric acid type A receptor subunit alpha 4
multiple interactions
ISO
delta-hexachlorocyclohexane results in decreased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]
CTD
PMID:11156579
NCBI chr14:36,944,747...37,021,652
Ensembl chr14:36,590,782...36,665,844
G
Gabra6
gamma-aminobutyric acid type A receptor subunit alpha6
multiple interactions
ISO
delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]
CTD
PMID:9316872
NCBI chr10:27,311,965...27,327,337
Ensembl chr10:26,810,423...26,825,769
G
Gabrb1
gamma-aminobutyric acid type A receptor subunit beta1
multiple interactions
ISO
delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]
CTD
PMID:11156579
NCBI chr14:36,434,339...36,917,920
Ensembl chr14:36,080,393...36,548,948
G
Gabrb2
gamma-aminobutyric acid type A receptor subunit beta 2
multiple interactions
ISO
delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in decreased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]
CTD
PMID:11156579
NCBI chr10:27,438,127...27,657,680
Ensembl chr10:26,936,551...27,151,251
G
Gabrb3
gamma-aminobutyric acid type A receptor subunit beta 3
multiple interactions
ISO
[delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; [delta-hexachlorocyclohexane co-treated with loreclezole] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; delta-hexachlorocyclohexane results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]
CTD
PMID:9316872
NCBI chr 1:117,602,772...117,838,230
Ensembl chr 1:108,296,124...108,698,961
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Gabrg2
gamma-aminobutyric acid type A receptor subunit gamma 2
multiple interactions
ISO
[delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; [delta-hexachlorocyclohexane co-treated with loreclezole] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in decreased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; delta-hexachlorocyclohexane results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]
CTD
PMID:9316872 PMID:11156579
NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,374,694...26,464,346
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Gsr
glutathione-disulfide reductase
multiple interactions
EXP
[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of GSR protein
CTD
PMID:16046044
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
G
Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
decreases expression
ISO
delta-hexachlorocyclohexane results in decreased expression of HSD3B1 mRNA
CTD
PMID:10993823
NCBI chr 2:188,858,574...188,864,694
Ensembl chr 2:186,169,863...186,175,999
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions
ISO
delta-hexachlorocyclohexane binds to and results in increased activity of NR1I2 protein
CTD
PMID:21115097
NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
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Pgr
progesterone receptor
multiple interactions
ISO
delta-hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]
CTD
PMID:26022396
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
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Shbg
sex hormone binding globulin
multiple interactions
ISO EXP
delta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to SHBG protein]
CTD
PMID:9171990
NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,332,941...54,351,057
G
Star
steroidogenic acute regulatory protein
multiple interactions
ISO
delta-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR protein]
CTD
PMID:10993823
NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672
G
Adm
adrenomedullin
increases expression
ISO
diphenylcyclopropenone results in increased expression of ADM mRNA
CTD
PMID:25236440
NCBI chr 1:174,164,178...174,182,372
Ensembl chr 1:164,745,466...164,747,654
G
Ankrd37
ankyrin repeat domain 37
increases expression
ISO
diphenylcyclopropenone results in increased expression of ANKRD37 mRNA
CTD
PMID:25236440
NCBI chr16:53,001,487...53,004,545
Ensembl chr16:46,268,443...46,271,963
G
Cdk12
cyclin-dependent kinase 12
decreases expression
ISO
diphenylcyclopropenone results in decreased expression of CDK12 mRNA
CTD
PMID:25236440
NCBI chr10:83,697,174...83,793,676
Ensembl chr10:83,201,211...83,280,888 Ensembl chr10:83,201,211...83,280,888
G
Dnmt3b
DNA methyltransferase 3 beta
decreases expression
ISO
diphenylcyclopropenone results in decreased expression of DNMT3B mRNA
CTD
PMID:25236440
NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:142,130,592...142,169,124
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
diphenylcyclopropenone results in increased expression of FOS mRNA
CTD
PMID:25236440
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
G
Fosl1
FOS like 1, AP-1 transcription factor subunit
increases expression
ISO
diphenylcyclopropenone results in increased expression of FOSL1 mRNA
CTD
PMID:25236440
NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:202,754,529...202,764,930
G
Hmox1
heme oxygenase 1
increases expression
ISO
diphenylcyclopropenone results in increased expression of HMOX1 mRNA
CTD
PMID:20491607 PMID:25236440
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
G
Maff
MAF bZIP transcription factor F
increases expression
ISO
diphenylcyclopropenone results in increased expression of MAFF mRNA
CTD
PMID:20491607
NCBI chr 7:112,792,787...112,804,139
Ensembl chr 7:110,912,499...110,923,851
G
Mt1
metallothionein 1
increases expression
ISO
diphenylcyclopropenone results in increased expression of MT1A mRNA
CTD
PMID:20491607
NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
G
Mt2
metallothionein 2
increases expression
ISO
diphenylcyclopropenone results in increased expression of MT2A mRNA
CTD
PMID:20491607
NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784
G
Rbm5
RNA binding motif protein 5
decreases expression
ISO
diphenylcyclopropenone results in decreased expression of RBM5 mRNA
CTD
PMID:25236440
NCBI chr 8:117,298,866...117,328,107
Ensembl chr 8:108,420,222...108,449,430
G
Srxn1
sulfiredoxin 1
increases expression
ISO
diphenylcyclopropenone results in increased expression of SRXN1 mRNA
CTD
PMID:25236440
NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:140,599,608...140,628,448
G
Stc2
stanniocalcin 2
decreases expression
ISO
diphenylcyclopropenone results in decreased expression of STC2 mRNA
CTD
PMID:25236440
NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,250,853...16,262,973
G
Txn1
thioredoxin 1
increases expression
ISO
diphenylcyclopropenone results in increased expression of TXN mRNA
CTD
PMID:20491607
NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:72,711,933...72,724,629
G
Angptl4
angiopoietin-like 4
increases expression
ISO
Esketamine results in increased expression of ANGPTL4 mRNA
CTD
PMID:38219984
NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:14,550,311...14,556,519
G
Ankrd1
ankyrin repeat domain 1
decreases expression
ISO
Esketamine results in decreased expression of ANKRD1 mRNA
CTD
PMID:38219984
NCBI chr 1:243,228,460...243,237,014
Ensembl chr 1:233,815,851...233,834,919
G
Ankrd2
ankyrin repeat domain 2
decreases expression
ISO
Esketamine results in decreased expression of ANKRD2 mRNA
CTD
PMID:38219984
NCBI chr 1:250,796,419...250,805,867
Ensembl chr 1:240,847,072...240,856,566
G
Arnt2
aryl hydrocarbon receptor nuclear translocator 2
increases expression
ISO
Esketamine results in increased expression of ARNT2 mRNA
CTD
PMID:38219984
NCBI chr 1:147,645,354...147,801,986
Ensembl chr 1:138,189,940...138,393,153
G
Arrdc4
arrestin domain containing 4
decreases expression
ISO
Esketamine results in decreased expression of ARRDC4 mRNA
CTD
PMID:38219984
NCBI chr 1:131,779,436...131,793,438
Ensembl chr 1:122,369,360...122,383,290
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Atf4
activating transcription factor 4
increases expression multiple interactions
ISO
Esketamine results in increased expression of ATF4 mRNA; Esketamine results in increased expression of ATF4 protein N-Methylaspartate results in decreased expression of [Esketamine results in increased expression of ATF4 protein]
CTD
PMID:38219984
NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446
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Atf6
activating transcription factor 6
increases expression
ISO
Esketamine results in increased expression of ATF6 mRNA
CTD
PMID:38219984
NCBI chr13:85,460,312...85,639,959
Ensembl chr13:82,930,034...83,107,177
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B3galt9
beta-1,3-galactosyltransferase 9
decreases expression
ISO
Esketamine results in decreased expression of B3GALT9 mRNA
CTD
PMID:38219984
NCBI chr 3:18,121,620...18,124,149
Ensembl chr 3:18,101,407...18,123,894 Ensembl chr 3:18,101,407...18,123,894
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Bax
BCL2 associated X, apoptosis regulator
affects expression multiple interactions increases expression
ISO
Esketamine affects the expression of BAX mRNA EIF2AK3 protein affects the reaction [Esketamine affects the expression of BAX mRNA]; N-Methylaspartate affects the reaction [Esketamine affects the expression of BAX mRNA] Esketamine results in increased expression of BAX protein
CTD
PMID:38219984
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression affects expression
ISO
EIF2AK3 protein affects the reaction [Esketamine affects the expression of BCL2 mRNA]; N-Methylaspartate affects the reaction [Esketamine affects the expression of BCL2 mRNA] Esketamine results in decreased expression of BCL2 protein
CTD
PMID:38219984
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
increases cleavage
ISO
Esketamine results in increased cleavage of CASP3 protein
CTD
PMID:38219984
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
G
Csta
cystatin A
increases expression
ISO
Esketamine results in increased expression of CSTA mRNA
CTD
PMID:38219984
NCBI chr11:78,125,813...78,136,818
Ensembl chr11:64,620,483...64,631,488
G
Ddit3
DNA-damage inducible transcript 3
increases expression multiple interactions
ISO
Esketamine results in increased expression of DDIT3 mRNA; Esketamine results in increased expression of DDIT3 protein EIF2AK3 protein affects the reaction [Esketamine results in increased expression of DDIT3 mRNA]; N-Methylaspartate results in decreased expression of [Esketamine results in increased expression of DDIT3 protein]
CTD
PMID:38219984
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
G
Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
increases expression multiple interactions increases phosphorylation
ISO
Esketamine results in increased expression of EIF2AK3 mRNA EIF2AK3 protein affects the reaction [Esketamine affects the expression of BAX mRNA]; EIF2AK3 protein affects the reaction [Esketamine affects the expression of BCL2 mRNA]; EIF2AK3 protein affects the reaction [Esketamine results in increased expression of DDIT3 mRNA] Esketamine results in increased phosphorylation of EIF2AK3 protein
CTD
PMID:38219984
NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911
G
Fam227b
family with sequence similarity 227, member B
decreases expression
ISO
Esketamine results in decreased expression of FAM227B mRNA
CTD
PMID:38219984
NCBI chr 3:133,686,602...133,845,793
Ensembl chr 3:113,233,205...113,392,320
G
Gata3
GATA binding protein 3
decreases expression
ISO
Esketamine results in decreased expression of GATA3 mRNA
CTD
PMID:38219984
NCBI chr17:73,544,234...73,575,670
Ensembl chr17:68,643,873...68,665,391
G
Gdf15
growth differentiation factor 15
increases expression
ISO
Esketamine results in increased expression of GDF15 mRNA
CTD
PMID:38219984
NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055
G
Gpr17
G protein-coupled receptor 17
increases expression
ISO
Esketamine results in increased expression of GPR17 mRNA
CTD
PMID:38219984
NCBI chr18:23,850,460...23,857,381
Ensembl chr18:23,577,242...23,582,966
G
Ifitm10
interferon induced transmembrane protein 10
increases expression
ISO
Esketamine results in increased expression of IFITM10 mRNA
CTD
PMID:38219984
NCBI chr 1:206,936,979...206,954,594
Ensembl chr 1:197,507,503...197,525,151
G
Igsf9b
immunoglobulin superfamily, member 9B
increases expression
ISO
Esketamine results in increased expression of IGSF9B mRNA
CTD
PMID:38219984
NCBI chr 8:33,971,779...34,027,390
Ensembl chr 8:25,712,644...25,758,554
G
Il12a
interleukin 12A
decreases expression
ISO
Esketamine results in decreased expression of IL12A mRNA
CTD
PMID:38219984
NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734
G
Klrg1
killer cell lectin like receptor G1
decreases expression
ISO
Esketamine results in decreased expression of KLRG1 mRNA
CTD
PMID:38219984
NCBI chr 4:157,127,571...157,139,372
Ensembl chr 4:155,455,495...155,467,424
G
Laptm5
lysosomal protein transmembrane 5
increases expression
ISO
Esketamine results in increased expression of LAPTM5 mRNA
CTD
PMID:38219984
NCBI chr 5:148,371,880...148,393,927
Ensembl chr 5:143,087,759...143,109,807
G
Mafb
MAF bZIP transcription factor B
increases expression
ISO
Esketamine results in increased expression of MAFB mRNA
CTD
PMID:38219984
NCBI chr 3:169,417,890...169,419,810
Ensembl chr 3:148,998,122...149,000,031
G
Marchf4
membrane associated ring-CH-type finger 4
decreases expression
ISO
Esketamine results in decreased expression of MARCHF4 mRNA
CTD
PMID:38219984
NCBI chr 9:81,527,703...81,647,448
Ensembl chr 9:74,078,434...74,198,199
G
Mdga1
MAM domain containing glycosylphosphatidylinositol anchor 1
increases expression
ISO
Esketamine results in increased expression of MDGA1 mRNA
CTD
PMID:38219984
NCBI chr20:7,901,856...7,965,834
Ensembl chr20:7,904,358...7,963,471
G
Ntng2
netrin G2
increases expression
ISO
Esketamine results in increased expression of NTNG2 mRNA
CTD
PMID:38219984
NCBI chr 3:32,889,856...32,949,032
Ensembl chr 3:12,492,639...12,545,890
G
Pde2a
phosphodiesterase 2A
increases expression
ISO
Esketamine results in increased expression of PDE2A mRNA
CTD
PMID:38219984
NCBI chr 1:165,235,623...165,327,466
Ensembl chr 1:155,813,180...155,915,434
G
Ppfia4
PTPRF interacting protein alpha 4
increases expression
ISO
Esketamine results in increased expression of PPFIA4 mRNA
CTD
PMID:38219984
NCBI chr13:48,305,844...48,354,329
Ensembl chr13:45,753,827...45,802,261
G
Prelid3a
PRELI domain containing 3A
decreases expression
ISO
Esketamine results in decreased expression of PRELID3A mRNA
CTD
PMID:38219984
NCBI chr18:63,268,824...63,301,772
Ensembl chr18:61,017,764...61,031,883
G
Pycr3
pyrroline-5-carboxylate reductase 3
decreases expression
ISO
Esketamine results in decreased expression of PYCR3 mRNA
CTD
PMID:38219984
NCBI chr 7:109,484,263...109,489,554
Ensembl chr 7:107,581,930...107,608,799
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Reln
reelin
decreases expression
ISO
Esketamine results in decreased expression of RELN mRNA
CTD
PMID:38219984
NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:12,736,130...13,162,211
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Rgs5
regulator of G-protein signaling 5
decreases expression
ISO
Esketamine results in decreased expression of RGS5 mRNA
CTD
PMID:38219984
NCBI chr13:84,381,077...84,417,875
Ensembl chr13:81,836,304...81,885,518
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Rida
reactive intermediate imine deaminase A homolog
decreases expression
ISO
Esketamine results in decreased expression of RIDA mRNA
CTD
PMID:38219984
NCBI chr 7:67,576,586...67,590,493
Ensembl chr 7:65,691,435...65,705,716
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Rora
RAR-related orphan receptor A
increases expression
ISO
Esketamine results in increased expression of RORA mRNA
CTD
PMID:38219984
NCBI chr 8:78,182,710...78,915,730
Ensembl chr 8:69,301,733...70,025,931
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Sall4
spalt-like transcription factor 4
decreases expression
ISO
Esketamine results in decreased expression of SALL4 mRNA
CTD
PMID:38219984
NCBI chr 3:177,891,705...177,909,743
Ensembl chr 3:157,474,642...157,490,822
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Sema5a
semaphorin 5A
decreases expression
ISO
Esketamine results in decreased expression of SEMA5A mRNA
CTD
PMID:38219984
NCBI chr 2:85,020,724...85,451,938
Ensembl chr 2:83,309,843...83,741,084
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Slc6a12
solute carrier family 6 member 12
increases expression
ISO
Esketamine results in increased expression of SLC6A12 mRNA
CTD
PMID:38219984
NCBI chr 4:156,257,518...156,275,870
Ensembl chr 4:154,585,500...154,603,750
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Slco2a1
solute carrier organic anion transporter family, member 2a1
decreases expression
ISO
Esketamine results in decreased expression of SLCO2A1 mRNA
CTD
PMID:38219984
NCBI chr 8:112,467,739...112,551,923
Ensembl chr 8:103,588,916...103,672,546
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Slitrk6
SLIT and NTRK-like family, member 6
increases expression
ISO
Esketamine results in increased expression of SLITRK6 mRNA
CTD
PMID:38219984
NCBI chr15:93,977,812...93,984,431
Ensembl chr15:87,563,322...87,570,393
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Spp1
secreted phosphoprotein 1
increases expression
ISO
Esketamine results in increased expression of SPP1 mRNA
CTD
PMID:38219984
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162
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Sycp2
synaptonemal complex protein 2
increases expression
ISO
Esketamine results in increased expression of SYCP2 mRNA
CTD
PMID:38219984
NCBI chr 3:185,814,033...185,876,516
Ensembl chr 3:165,436,331...165,498,789
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Tnnc1
troponin C1, slow skeletal and cardiac type
decreases expression
ISO
Esketamine results in decreased expression of TNNC1 mRNA
CTD
PMID:38219984
NCBI chr16:6,408,607...6,412,070
Ensembl chr16:6,402,171...6,405,634
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Trpv3
transient receptor potential cation channel, subfamily V, member 3
increases expression
ISO
Esketamine results in increased expression of TRPV3 mRNA
CTD
PMID:38219984
NCBI chr10:58,382,054...58,413,657
Ensembl chr10:57,883,546...57,913,296
G
Unc13a
unc-13 homolog A
increases expression
ISO
Esketamine results in increased expression of UNC13A mRNA
CTD
PMID:38219984
NCBI chr16:18,367,891...18,415,808
Ensembl chr16:18,336,229...18,381,872
G
Vwa5a
von Willebrand factor A domain containing 5A
increases expression
ISO
Esketamine results in increased expression of VWA5A mRNA
CTD
PMID:38219984
NCBI chr 8:47,712,352...47,745,847
Ensembl chr 8:38,815,210...38,839,112
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Xbp1
X-box binding protein 1
increases expression
ISO
Esketamine results in increased expression of XBP1 mRNA
CTD
PMID:38219984
NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693
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Zfp239
zinc finger protein 239
decreases expression
ISO
Esketamine results in decreased expression of ZNF239 mRNA
CTD
PMID:38219984
NCBI chr 4:152,701,818...152,711,698
Ensembl chr 4:151,029,405...151,039,529
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
multiple interactions
ISO
fenchone binds to and results in decreased activity of NR3C1 protein
CTD
PMID:27633901
NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375
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Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
fenchone binds to and results in decreased activity of PPARG protein
CTD
PMID:27633901
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
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Casp3
caspase 3
multiple interactions
ISO
friedelin inhibits the reaction [Ethanol results in increased expression of CASP3 protein]
CTD
PMID:37939858
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
friedelin inhibits the reaction [Ethanol results in increased expression of PARP1 protein]
CTD
PMID:37939858
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
friedelin inhibits the reaction [Ethanol results in increased expression of RELA protein]
CTD
PMID:37939858
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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Abca1
ATP binding cassette subfamily A member 1
increases expression
ISO
Hexachlorocyclohexane results in increased expression of ABCA1 mRNA
CTD
PMID:24356939
NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170
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Abcb1a
ATP binding cassette subfamily B member 1A
increases expression
ISO
Hexachlorocyclohexane results in increased expression of ABCB1 mRNA
CTD
PMID:24464585
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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Abcc3
ATP binding cassette subfamily C member 3
increases expression
EXP
Hexachlorocyclohexane results in increased expression of ABCC3 mRNA
CTD
PMID:17785943
NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595
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Abcg1
ATP binding cassette subfamily G member 1
increases expression
ISO
Hexachlorocyclohexane results in increased expression of ABCG1 mRNA
CTD
PMID:24356939
NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,126,687...9,182,948
G
Abcg2
ATP binding cassette subfamily G member 2
increases expression
ISO
Hexachlorocyclohexane results in increased expression of ABCG2 mRNA
CTD
PMID:24464585
NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
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Abl1
ABL proto-oncogene 1, non-receptor tyrosine kinase
increases methylation
ISO
Hexachlorocyclohexane results in increased methylation of ABL1 promoter
CTD
PMID:35788154
NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065
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Ache
acetylcholinesterase
multiple interactions decreases activity increases activity affects activity
ISO EXP
Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of ACHE protein] Hexachlorocyclohexane results in decreased activity of ACHE protein Hexachlorocyclohexane results in increased activity of ACHE protein Hexachlorocyclohexane affects the activity of ACHE protein
CTD
PMID:6186625 PMID:19893075 PMID:20663516
NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651
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Acly
ATP citrate lyase
decreases expression affects activity
EXP
Hexachlorocyclohexane results in decreased expression of ACLY mRNA Hexachlorocyclohexane affects the activity of ACLY protein
CTD
PMID:7535533 PMID:17785943
NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,412,049...85,463,320
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Aco2
aconitase 2
increases expression
EXP
Hexachlorocyclohexane results in increased expression of ACO2 mRNA
CTD
PMID:17785943
NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:113,385,646...113,428,261
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Acsl5
acyl-CoA synthetase long-chain family member 5
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of ACSL5 mRNA
CTD
PMID:17785943
NCBI chr 1:264,294,851...264,341,943
Ensembl chr 1:254,292,521...254,336,607
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Actb
actin, beta
affects expression
EXP
Hexachlorocyclohexane affects the expression of ACTB mRNA
CTD
PMID:22001173
NCBI chr12:16,776,664...16,779,634
Ensembl chr12:11,663,109...11,672,877
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Acvr1
activin A receptor type 1
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of ACVR1 mRNA
CTD
PMID:17785943
NCBI chr 3:63,387,378...63,506,980
Ensembl chr 3:42,978,561...43,098,241
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Acvr1c
activin A receptor type 1C
increases expression
EXP
Hexachlorocyclohexane results in increased expression of ACVR1C mRNA
CTD
PMID:17785943
NCBI chr 3:63,224,322...63,301,252
Ensembl chr 3:42,822,610...42,892,327
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Add3
adducin 3
affects expression
EXP
Hexachlorocyclohexane affects the expression of ADD3 mRNA
CTD
PMID:17785943
NCBI chr 1:262,152,722...262,260,504
Ensembl chr 1:252,147,386...252,255,124
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Ahr
aryl hydrocarbon receptor
increases expression
EXP
Hexachlorocyclohexane results in increased expression of AHR mRNA
CTD
PMID:17785943 PMID:25572523
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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Ak4
adenylate kinase 4
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of AK4 mRNA
CTD
PMID:24356939
NCBI chr 5:121,154,565...121,214,403
Ensembl chr 5:116,039,616...116,098,618
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Akr7a3
aldo-keto reductase family 7 member A3
increases expression
EXP
Hexachlorocyclohexane results in increased expression of AKR7A3 mRNA
CTD
PMID:17785943
NCBI chr 5:156,876,721...156,884,599
Ensembl chr 5:151,584,479...151,601,394
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Akt1
AKT serine/threonine kinase 1
decreases phosphorylation
EXP
Hexachlorocyclohexane results in decreased phosphorylation of AKT1 protein
CTD
PMID:30248393
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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Aldh8a1
aldehyde dehydrogenase 8 family, member A1
increases expression
ISO
Hexachlorocyclohexane results in increased expression of ALDH8A1 mRNA
CTD
PMID:24356939
NCBI chr 1:18,003,507...18,022,952
Ensembl chr 1:16,183,940...16,203,385
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Alk
ALK receptor tyrosine kinase
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of ALK mRNA
CTD
PMID:28263720
NCBI chr 6:28,631,431...29,351,321
Ensembl chr 6:22,880,625...23,598,034
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Alpl
alkaline phosphatase, biomineralization associated
multiple interactions increases expression increases activity
EXP
[Hexachlorocyclohexane co-treated with isoproturon] results in decreased activity of ALPL protein; [Hexachlorocyclohexane co-treated with isoproturon] results in increased expression of ALPL protein Hexachlorocyclohexane results in increased expression of ALPL protein Hexachlorocyclohexane results in increased activity of ALPL protein
CTD
PMID:11180283
NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:149,951,409...150,006,446
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Apob
apolipoprotein B
affects expression
EXP
Hexachlorocyclohexane affects the expression of APOB mRNA
CTD
PMID:17785943
NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:30,844,368...30,892,497
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Ar
androgen receptor
affects binding multiple interactions
EXP ISO
Hexachlorocyclohexane binds to AR protein [DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Hydrocarbons, Chlorinated] inhibits the reaction [Dihydrotestosterone results in increased expression of AR mRNA]; Hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]
CTD
PMID:14565775 PMID:21295777 PMID:26022396
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925
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Armc6
armadillo repeat containing 6
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of ARMC6 mRNA
CTD
PMID:17785943
NCBI chr16:19,225,058...19,235,479
Ensembl chr16:19,191,093...19,206,047
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Arnt
aryl hydrocarbon receptor nuclear translocator
increases expression
EXP
Hexachlorocyclohexane results in increased expression of ARNT mRNA
CTD
PMID:25572523
NCBI chr 2:185,686,703...185,745,546
Ensembl chr 2:182,997,736...183,056,580
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Arsa
arylsulfatase A
decreases activity
ISO
Hexachlorocyclohexane results in decreased activity of ARSA protein
CTD
PMID:16818664
NCBI chr 7:122,422,971...122,426,971
Ensembl chr 7:120,543,362...120,548,783
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Asip
agouti signaling protein
increases response to substance
ISO
A mutant form results in increased susceptibility to Hexachlorocyclohexane
CTD
PMID:2445499
NCBI chr 3:163,933,768...164,021,377
Ensembl chr 3:143,555,696...143,561,171
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Asns
asparagine synthetase (glutamine-hydrolyzing)
increases expression
ISO
Hexachlorocyclohexane results in increased expression of ASNS mRNA
CTD
PMID:24356939
NCBI chr 4:36,752,061...36,769,970
Ensembl chr 4:35,785,237...35,803,423
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Atp5f1d
ATP synthase F1 subunit delta
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of ATP5F1D mRNA
CTD
PMID:17785943
NCBI chr 7:10,211,260...10,218,989
Ensembl chr 7:9,560,608...9,565,929
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Atp5if1
ATP synthase inhibitory factor subunit 1
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of ATP5IF1 mRNA
CTD
PMID:17785943
NCBI chr 5:150,022,960...150,026,677
Ensembl chr 5:144,738,950...144,742,668
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Bax
BCL2 associated X, apoptosis regulator
increases expression multiple interactions decreases expression
ISO EXP
Hexachlorocyclohexane results in increased expression of BAX mRNA; Hexachlorocyclohexane results in increased expression of BAX protein Estradiol inhibits the reaction [Hexachlorocyclohexane results in decreased expression of BAX protein]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in decreased expression of BAX protein]; Hexachlorocyclohexane promotes the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of BAX protein]
CTD
PMID:14688026 PMID:18174961 PMID:19041923
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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Bche
butyrylcholinesterase
multiple interactions decreases activity
ISO
Hexachlorocyclohexane inhibits the reaction [[Resveratrol co-treated with Ascorbic Acid co-treated with Thioctic Acid co-treated with Vitamin E] results in increased activity of BCHE protein] Hexachlorocyclohexane results in decreased activity of BCHE protein
CTD
PMID:20455324 PMID:20663516
NCBI chr 2:160,607,289...160,699,760
Ensembl chr 2:158,307,584...158,401,148
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Bcl2
BCL2, apoptosis regulator
decreases expression increases expression multiple interactions
ISO EXP
Hexachlorocyclohexane results in decreased expression of BCL2 protein Hexachlorocyclohexane results in increased expression of BCL2 mRNA; Hexachlorocyclohexane results in increased expression of BCL2 protein [Hexachlorocyclohexane co-treated with Estradiol] results in increased expression of BCL2 protein Hexachlorocyclohexane promotes the reaction [BECN1 protein binds to BCL2 protein]
CTD
PMID:14688026 PMID:18174961 PMID:19041923
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bcl2l1
Bcl2-like 1
multiple interactions increases expression
EXP
Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased expression of BCL2L1 protein]; TEMPO inhibits the reaction [Hexachlorocyclohexane results in increased expression of BCL2L1 protein]
CTD
PMID:19041923 PMID:22001173
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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Bcl6
BCL6, transcription repressor
increases expression
ISO
Hexachlorocyclohexane results in increased expression of BCL6 mRNA
CTD
PMID:24356939
NCBI chr11:90,358,753...90,382,049
Ensembl chr11:76,854,090...76,877,389
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Bdnf
brain-derived neurotrophic factor
increases expression
EXP
Hexachlorocyclohexane results in increased expression of BDNF protein
CTD
PMID:11279263
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
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Becn1
beclin 1
affects expression multiple interactions
EXP
Hexachlorocyclohexane affects the expression of BECN1 protein Hexachlorocyclohexane promotes the reaction [BECN1 protein binds to BCL2 protein]
CTD
PMID:19041923
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742
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Bhlha15
basic helix-loop-helix family, member a15
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of BHLHA15 mRNA
CTD
PMID:28263720
NCBI chr12:15,534,123...15,538,299
Ensembl chr12:10,420,467...10,424,713
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Bhlhe40
basic helix-loop-helix family, member e40
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of BHLHE40 mRNA
CTD
PMID:17785943
NCBI chr 4:143,174,450...143,180,150
Ensembl chr 4:141,618,476...141,624,774
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Birc3
baculoviral IAP repeat-containing 3
increases expression
ISO
Hexachlorocyclohexane results in increased expression of BIRC3 mRNA
CTD
PMID:24356939
NCBI chr 8:13,285,702...13,313,329
Ensembl chr 8:5,000,845...5,015,802
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C8h15orf39
similar to human chromosome 15 open reading frame 39
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of C15ORF39 mRNA
CTD
PMID:24356939
NCBI chr 8:66,542,269...66,551,835
Ensembl chr 8:57,645,756...57,655,941
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Calr
calreticulin
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of CALR mRNA
CTD
PMID:17785943
NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414
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Cars1
cysteinyl-tRNA synthetase 1
increases expression
ISO
Hexachlorocyclohexane results in increased expression of CARS1 mRNA
CTD
PMID:24356939
NCBI chr 1:208,183,092...208,225,425
Ensembl chr 1:198,753,691...198,795,941
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Casp3
caspase 3
increases expression increases activity multiple interactions decreases activity
EXP ISO
Hexachlorocyclohexane results in increased expression of CASP3 mRNA; Hexachlorocyclohexane results in increased expression of CASP3 protein Hexachlorocyclohexane results in increased activity of CASP3 protein [Hexachlorocyclohexane co-treated with Dieldrin] results in increased activity of CASP3 protein; Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP3 protein]; TEMPO inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP3 protein] Hexachlorocyclohexane results in decreased activity of CASP3 protein
CTD
PMID:19038305 PMID:19041923 PMID:19221147 PMID:19815060 PMID:20036686 PMID:22001173 More...
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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Casp7
caspase 7
multiple interactions
EXP
[Hexachlorocyclohexane co-treated with Dieldrin] results in increased activity of CASP7 protein
CTD
PMID:20036686
NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
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Casp9
caspase 9
increases expression multiple interactions increases activity decreases activity
EXP
Hexachlorocyclohexane results in increased expression of CASP9 protein Ro 31-8220 inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP9 protein]; TEMPO inhibits the reaction [Hexachlorocyclohexane results in increased activity of CASP9 protein] Hexachlorocyclohexane results in decreased activity of CASP9 protein
CTD
PMID:19038305 PMID:19041923 PMID:22001173
Ensembl chr 5:154,109,046...154,126,626
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Cast
calpastatin
increases expression
EXP
Hexachlorocyclohexane results in increased expression of CAST mRNA
CTD
PMID:17785943
NCBI chr 2:5,707,633...5,817,213
Ensembl chr 2:3,973,112...4,082,659
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Cat
catalase
multiple interactions increases activity decreases activity
ISO EXP
Plant Extracts inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein] Hexachlorocyclohexane results in increased activity of CAT protein [Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of CAT protein; [Hexachlorocyclohexane co-treated with Dichlorvos co-treated with Plant Extracts] results in decreased activity of CAT protein; [Hexachlorocyclohexane co-treated with Dichlorvos] results in decreased activity of CAT protein; [Phenobarbital co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein; [Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]; gadolinium chloride inhibits the reaction [[Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of CAT protein]
CTD
PMID:1708174 PMID:2429406 PMID:2469257 PMID:9057899 PMID:9467884 PMID:9704597 PMID:10097797 PMID:10817630 PMID:11349524 PMID:11404799 PMID:11561191 PMID:12364975 PMID:12516873 PMID:16046044 PMID:16127354 PMID:16432761 PMID:17884035 PMID:17997001 PMID:20182699 PMID:20455324 PMID:21976817 PMID:22224058 PMID:22302394 More...
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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Ccng2
cyclin G2
increases expression
ISO
Hexachlorocyclohexane results in increased expression of CCNG2 mRNA
CTD
PMID:24356939
NCBI chr14:15,088,694...15,097,190
Ensembl chr14:14,804,322...14,812,830
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Cd47
Cd47 molecule
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of CD47 mRNA
CTD
PMID:17785943
NCBI chr11:64,374,816...64,438,763
Ensembl chr11:50,906,177...50,969,425
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Cd69
Cd69 molecule
increases expression
ISO
Hexachlorocyclohexane results in increased expression of CD69 mRNA
CTD
PMID:24356939
NCBI chr 4:164,411,485...164,419,403
Ensembl chr 4:162,725,446...162,733,542
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Cd84
CD84 molecule
increases expression
ISO
Hexachlorocyclohexane results in increased expression of CD84 mRNA
CTD
PMID:24356939
NCBI chr13:86,859,979...86,899,984
Ensembl chr13:84,327,553...84,362,076
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Cdc42
cell division cycle 42
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of CDC42 mRNA
CTD
PMID:17785943
NCBI chr 5:154,838,478...154,876,629
Ensembl chr 5:149,553,724...149,593,111
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Cdipt
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
affects activity
ISO
Hexachlorocyclohexane affects the activity of CDIPT protein
CTD
PMID:2579070
NCBI chr 1:191,013,632...191,017,943
Ensembl chr 1:181,583,141...181,587,408
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression decreases expression multiple interactions
ISO EXP
Hexachlorocyclohexane results in increased expression of CDKN1A mRNA; Hexachlorocyclohexane results in increased expression of CDKN1A protein Hexachlorocyclohexane results in decreased expression of CDKN1A protein Hexachlorocyclohexane affects the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in increased expression of CDKN1A protein]
CTD
PMID:14688026 PMID:17785943 PMID:18174961
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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Cebpb
CCAAT/enhancer binding protein beta
increases expression
ISO
Hexachlorocyclohexane results in increased expression of CEBPB mRNA
CTD
PMID:24356939
NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473
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Ces2h
carboxylesterase 2H
increases expression
EXP
Hexachlorocyclohexane results in increased expression of CES2 mRNA
CTD
PMID:17785943
NCBI chr19:49,884,164...49,898,764
Ensembl chr19:32,974,242...32,988,830
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Chac1
ChaC glutathione-specific gamma-glutamylcyclotransferase 1
increases expression
ISO
Hexachlorocyclohexane results in increased expression of CHAC1 mRNA
CTD
PMID:23824090 PMID:24356939
NCBI chr 3:126,796,131...126,799,352
Ensembl chr 3:106,342,302...106,345,526
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Cidea
cell death-inducing DFFA-like effector a
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of CIDEA mRNA
CTD
PMID:17785943
NCBI chr18:63,164,817...63,190,384
Ensembl chr18:60,894,874...60,920,481
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Cish
cytokine inducible SH2-containing protein
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of CISH mRNA
CTD
PMID:17785943
NCBI chr 8:116,850,969...116,855,917
Ensembl chr 8:107,972,306...107,977,250
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Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
increases expression
EXP
Hexachlorocyclohexane results in increased expression of CITED2 mRNA
CTD
PMID:17785943
NCBI chr 1:14,132,303...14,134,746
Ensembl chr 1:12,312,160...12,314,897
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Clcn5
chloride voltage-gated channel 5
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of CLCN5 mRNA
CTD
PMID:17785943
NCBI chr X:17,857,260...18,011,844
Ensembl chr X:15,185,451...15,334,264
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Clu
clusterin
increases expression
EXP
Hexachlorocyclohexane results in increased expression of CLU protein
CTD
PMID:17997001
NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315
G
Cnga1
cyclic nucleotide gated channel subunit alpha 1
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of CNGA1 mRNA
CTD
PMID:17785943
NCBI chr14:35,920,948...35,959,065
Ensembl chr14:35,567,125...35,605,065
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Cnp
2',3'-cyclic nucleotide 3' phosphodiesterase
decreases activity
EXP
Hexachlorocyclohexane results in decreased activity of CNP protein
CTD
PMID:1701514
NCBI chr10:86,011,504...86,018,063
Ensembl chr10:85,511,160...85,517,720
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Cpd
carboxypeptidase D
increases expression
EXP
Hexachlorocyclohexane results in increased expression of CPD mRNA
CTD
PMID:17785943
NCBI chr10:62,121,681...62,185,638
Ensembl chr10:61,623,526...61,687,491
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Crim1
cysteine rich transmembrane BMP regulator 1
increases expression
ISO
Hexachlorocyclohexane results in increased expression of CRIM1 mRNA
CTD
PMID:24356939
NCBI chr 6:22,447,983...22,622,459
Ensembl chr 6:16,697,829...16,870,259
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Cst8
cystatin 8
affects expression
EXP
Hexachlorocyclohexane affects the expression of CST8 mRNA
CTD
PMID:17785943
NCBI chr 3:156,697,776...156,704,413
Ensembl chr 3:136,244,636...136,251,273
G
Cx3cr1
C-X3-C motif chemokine receptor 1
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of CX3CR1 mRNA
CTD
PMID:24356939
NCBI chr 8:128,661,294...128,679,048
Ensembl chr 8:119,782,595...119,800,014
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Cycs
cytochrome c, somatic
affects expression
EXP
Hexachlorocyclohexane affects the expression of CYCS mRNA
CTD
PMID:17785943
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
decreases expression multiple interactions
ISO EXP
Hexachlorocyclohexane results in decreased expression of CYP11A1 mRNA Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11A1 mRNA] Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of CYP11A1 protein]
CTD
PMID:15749814 PMID:17080404
NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338
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Cyp11b2
cytochrome P450, family 11, subfamily b, polypeptide 2
multiple interactions
ISO
Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11B1 mRNA]
CTD
PMID:17080404
NCBI chr 7:108,719,349...108,726,024
Ensembl chr 7:106,838,590...106,845,004
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Cyp11b3
cytochrome P450, family 11, subfamily b, polypeptide 3
multiple interactions
ISO
Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP11B2 mRNA]
CTD
PMID:17080404
NCBI chr 7:108,689,319...108,694,808
Ensembl chr 7:106,808,559...106,814,048
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Cyp17a1
cytochrome P450, family 17, subfamily a, polypeptide 1
multiple interactions
ISO
Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA]
CTD
PMID:17080404
NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
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Cyp19a1
cytochrome P450, family 19, subfamily a, polypeptide 1
multiple interactions increases expression increases activity decreases activity
ISO
Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of CYP19A1 mRNA] Hexachlorocyclohexane results in increased expression of CYP19A1 mRNA Hexachlorocyclohexane results in increased activity of CYP19A1 protein Hexachlorocyclohexane results in decreased activity of CYP19A1 protein
CTD
PMID:12849724 PMID:17080404
NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases activity increases expression multiple interactions
ISO EXP
Hexachlorocyclohexane results in increased activity of CYP1A1 protein Hexachlorocyclohexane results in increased expression of CYP1A1 mRNA; Hexachlorocyclohexane results in increased expression of CYP1A1 protein Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A1 protein; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A1 protein]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A1 protein] Hexachlorocyclohexane inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
CTD
PMID:11684361 PMID:12842176 PMID:15620088 PMID:16641539 PMID:17919674 PMID:17984293 PMID:18174961 PMID:18486174 PMID:23927878 PMID:25572523 More...
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
increases activity multiple interactions increases expression
EXP
Hexachlorocyclohexane results in increased activity of CYP1A2 protein Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A2 protein; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A2 protein]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP1A2 protein] Hexachlorocyclohexane results in increased expression of CYP1A2 mRNA; Hexachlorocyclohexane results in increased expression of CYP1A2 protein
CTD
PMID:12842176 PMID:16641539 PMID:17919674 PMID:17984293 PMID:18486174 PMID:23927878 PMID:25572523 More...
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of CYP1B1 mRNA
CTD
PMID:17785943
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
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Cyp2a1
cytochrome P450, family 2, subfamily a, polypeptide 1
increases activity
EXP
Hexachlorocyclohexane results in increased activity of CYP2A1 protein
CTD
PMID:3569844
NCBI chr 1:91,359,278...91,372,554
Ensembl chr 1:82,231,611...82,244,887
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
increases expression multiple interactions increases activity
EXP
Hexachlorocyclohexane results in increased expression of CYP2B1 mRNA; Hexachlorocyclohexane results in increased expression of CYP2B1 protein Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B1 protein; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B1 protein]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B1 protein] Hexachlorocyclohexane results in increased activity of CYP2B1 protein
CTD
PMID:11684361 PMID:12842176 PMID:17919674 PMID:17984293 PMID:18486174 PMID:23927878 PMID:25572523 More...
NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
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Cyp2b2
cytochrome P450, family 2, subfamily b, polypeptide 2
increases expression multiple interactions increases activity
EXP
Hexachlorocyclohexane results in increased expression of CYP2B2 mRNA; Hexachlorocyclohexane results in increased expression of CYP2B2 protein Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B2 protein; Methylcholanthrene promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B2 protein]; Phenobarbital promotes the reaction [Hexachlorocyclohexane results in increased expression of and results in increased activity of CYP2B2 protein] Hexachlorocyclohexane results in increased activity of CYP2B2 protein
CTD
PMID:11684361 PMID:12842176 PMID:17785943 PMID:17919674 PMID:17984293 PMID:18486174 PMID:23927878 PMID:25572523 More...
NCBI chr 1:90,722,243...90,736,272
Ensembl chr 1:81,594,555...81,608,566
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression
ISO
Hexachlorocyclohexane results in increased expression of CYP2B6 mRNA; Hexachlorocyclohexane results in increased expression of CYP2B6 protein
CTD
PMID:15548381 PMID:20035023
NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
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Cyp2c11
cytochrome P450, subfamily 2, polypeptide 11
increases expression
EXP
Hexachlorocyclohexane results in increased expression of CYP2C11 mRNA; Hexachlorocyclohexane results in increased expression of CYP2C11 protein
CTD
PMID:11684361 PMID:16837770
NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:236,762,842...236,799,066
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Cyp2c12
cytochrome P450, family 2, subfamily c, polypeptide 12
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of CYP2C12 mRNA
CTD
PMID:17785943
NCBI chr 1:248,619,887...248,681,945
Ensembl chr 1:238,699,854...238,757,019
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Cyp2d1
cytochrome P450, family 2, subfamily d, polypeptide 1
increases expression
EXP
Hexachlorocyclohexane results in increased expression of CYP2D1 mRNA
CTD
PMID:25572523
NCBI chr 7:115,789,026...115,793,430
Ensembl chr 7:113,908,947...113,922,084
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of CYP2D6 mRNA
CTD
PMID:20035023
NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases activity increases expression decreases response to substance decreases expression
EXP ISO
Hexachlorocyclohexane results in increased activity of CYP2E1 protein Hexachlorocyclohexane results in increased expression of CYP2E1 mRNA; Hexachlorocyclohexane results in increased expression of CYP2E1 protein CYP2E1 protein results in decreased susceptibility to Hexachlorocyclohexane Hexachlorocyclohexane results in decreased expression of CYP2E1 mRNA
CTD
PMID:12842176 PMID:14631868 PMID:17919674 PMID:17984293 PMID:20035023 PMID:21458603 PMID:23927878 PMID:25572523 More...
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression increases activity
EXP ISO
Hexachlorocyclohexane results in increased expression of CYP3A2 mRNA; Hexachlorocyclohexane results in increased expression of CYP3A2 protein Hexachlorocyclohexane results in increased expression of CYP3A4 protein Hexachlorocyclohexane results in increased activity of CYP3A2 protein
CTD
PMID:3569844 PMID:11684361 PMID:15548381 PMID:16837770
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases expression affects expression
EXP
Hexachlorocyclohexane results in increased expression of CYP3A23-3A1 mRNA Hexachlorocyclohexane affects the expression of CYP3A23-3A1 mRNA
CTD
PMID:14613717 PMID:22001173 PMID:25572523
NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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Cyp51
cytochrome P450, family 51
increases expression
EXP
Hexachlorocyclohexane results in increased expression of CYP51 mRNA
CTD
PMID:17785943
NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,036,865...30,055,410 Ensembl chr 6:30,036,865...30,055,410
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Dap3
death associated protein 3
increases expression
ISO
Hexachlorocyclohexane results in increased expression of DAP3 mRNA
CTD
PMID:23777605
NCBI chr 2:176,617,151...176,645,293
Ensembl chr 2:174,318,983...174,346,461
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Dcn
decorin
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of DCN mRNA
CTD
PMID:17785943
NCBI chr 7:34,167,973...34,208,004
Ensembl chr 7:32,281,252...32,321,270
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Dnajb4
DnaJ heat shock protein family (Hsp40) member B4
increases expression
ISO
Hexachlorocyclohexane results in increased expression of DNAJB4 mRNA
CTD
PMID:24356939
NCBI chr 2:243,790,296...243,819,042
Ensembl chr 2:241,130,340...241,159,089
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Dnajc5
DnaJ heat shock protein family (Hsp40) member C5
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of DNAJC5 mRNA
CTD
PMID:17785943
NCBI chr 3:188,999,508...189,033,455
Ensembl chr 3:168,621,969...168,655,935
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Drd2
dopamine receptor D2
increases expression
EXP
Hexachlorocyclohexane results in increased expression of DRD2 mRNA
CTD
PMID:25572523
NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875
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Dusp1
dual specificity phosphatase 1
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of DUSP1 mRNA
CTD
PMID:17785943
NCBI chr10:17,184,853...17,187,646
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Dusp10
dual specificity phosphatase 10
increases expression
ISO
Hexachlorocyclohexane results in increased expression of DUSP10 mRNA
CTD
PMID:24356939
NCBI chr13:98,145,317...98,183,304
Ensembl chr13:95,614,292...95,651,716
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Eef1a1
eukaryotic translation elongation factor 1 alpha 1
affects expression
EXP
Hexachlorocyclohexane affects the expression of EEF1A1 mRNA
CTD
PMID:22001173
NCBI chr 8:88,221,839...88,225,688
Ensembl chr 8:79,341,557...79,344,839
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Egr1
early growth response 1
increases expression
EXP
Hexachlorocyclohexane results in increased expression of EGR1 mRNA
CTD
PMID:17785943
NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766
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Eif2b3
eukaryotic translation initiation factor 2B subunit gamma
affects expression
EXP
Hexachlorocyclohexane affects the expression of EIF2B3 mRNA
CTD
PMID:22001173
NCBI chr 5:135,728,764...135,795,276
Ensembl chr 5:130,492,220...130,563,332
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Eif2b4
eukaryotic translation initiation factor 2B subunit delta
affects expression
EXP
Hexachlorocyclohexane affects the expression of EIF2B4 mRNA
CTD
PMID:22001173
NCBI chr 6:30,903,148...30,908,803
Ensembl chr 6:25,183,186...25,188,829
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Eif5
eukaryotic translation initiation factor 5
increases expression
EXP
Hexachlorocyclohexane results in increased expression of EIF5 mRNA
CTD
PMID:17785943
NCBI chr 6:136,410,333...136,418,827
Ensembl chr 6:130,589,143...130,597,656
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Epha3
Eph receptor A3
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA3 mRNA
CTD
PMID:28263720
NCBI chr11:14,585,041...14,920,721
Ensembl chr11:1,140,985...1,473,900
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Epha8
Eph receptor A8
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of EPHA8 mRNA
CTD
PMID:28263720
NCBI chr 5:154,449,566...154,476,966
Ensembl chr 5:149,166,697...149,193,399
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Esr1
estrogen receptor 1
multiple interactions increases activity affects binding decreases expression
ISO
[DDT analog co-treated with Hexachlorocyclohexane analog co-treated with Chlorobenzenes co-treated with Mirex co-treated with Polychlorinated Biphenyls co-treated with Chlordan co-treated with Toxaphene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of ESR1 mRNA; [Hexachlorocyclohexane co-treated with DDT] results in increased expression of ESR1; Hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein] Hexachlorocyclohexane results in increased activity of ESR1 protein Hexachlorocyclohexane binds to ESR1 protein Hexachlorocyclohexane results in decreased expression of ESR1 protein Hexachlorocyclohexane binds to and results in increased activity of ESR1 protein
CTD
PMID:14579009 PMID:15253041 PMID:16329587 PMID:20209442 PMID:21278053 PMID:21295777 PMID:26022396 PMID:26139245 More...
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
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Esr2
estrogen receptor 2
increases activity
ISO
Hexachlorocyclohexane results in increased activity of ESR2 protein
CTD
PMID:15064155 PMID:26139245
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919
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Esrra
estrogen related receptor, alpha
increases expression
ISO
Hexachlorocyclohexane results in increased expression of ESRRA mRNA
CTD
PMID:23777605
NCBI chr 1:213,533,309...213,543,432
Ensembl chr 1:204,104,101...204,114,268
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Evi2a
ecotropic viral integration site 2A
increases expression
ISO
Hexachlorocyclohexane results in increased expression of EVI2A mRNA
CTD
PMID:24356939
NCBI chr10:64,485,760...64,489,660
Ensembl chr10:64,485,200...64,489,843
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Fam107b
family with sequence similarity 107, member B
increases expression
ISO
Hexachlorocyclohexane results in increased expression of FAM107B mRNA
CTD
PMID:24356939
NCBI chr17:79,387,795...79,594,165
Ensembl chr17:74,478,608...74,684,989
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Fas
Fas cell surface death receptor
increases expression
EXP
Hexachlorocyclohexane results in increased expression of FAS protein
CTD
PMID:19038305
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
increases expression
EXP
Hexachlorocyclohexane results in increased expression of FASLG protein
CTD
PMID:19038305
NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
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Fasn
fatty acid synthase
affects activity
EXP
Hexachlorocyclohexane affects the activity of FASN protein
CTD
PMID:7535533
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
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Fbxo32
F-box protein 32
increases expression
ISO
Hexachlorocyclohexane results in increased expression of FBXO32 mRNA
CTD
PMID:24356939
NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:89,730,232...89,765,436
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Fkbp3
FKBP prolyl isomerase 3
affects expression
EXP
Hexachlorocyclohexane affects the expression of FKBP3 mRNA
CTD
PMID:17785943
NCBI chr 6:88,850,137...88,862,542
Ensembl chr 6:83,113,786...83,127,011
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Fn1
fibronectin 1
affects expression
EXP
Hexachlorocyclohexane affects the expression of FN1 mRNA
CTD
PMID:17785943
NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
increases expression multiple interactions
ISO EXP
Hexachlorocyclohexane results in increased expression of FOS mRNA Hexachlorocyclohexane results in increased expression of FOS mRNA; Hexachlorocyclohexane results in increased expression of FOS protein alpha-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; Nifedipine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; tetrandrine inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA] W 7 inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]
CTD
PMID:1380685 PMID:1710164 PMID:7531829 PMID:7534335 PMID:10072926
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
G
Foxa1
forkhead box A1
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of FOXA1 mRNA
CTD
PMID:17785943
NCBI chr 6:80,838,380...80,871,195
Ensembl chr 6:75,103,503...75,136,188
G
Frat1
FRAT regulator of WNT signaling pathway 1
increases expression
ISO
Hexachlorocyclohexane results in increased expression of FRAT1 mRNA
CTD
PMID:24356939
NCBI chr 1:240,638,309...240,640,857
Ensembl chr 1:240,638,296...240,640,945
G
Fshb
follicle stimulating hormone subunit beta
multiple interactions
EXP
Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of CYP11A1 protein]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of STAR protein]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased phosphorylation of and affects the localization of GJA1 protein]
CTD
PMID:15749814
NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370
G
G6pd
glucose-6-phosphate dehydrogenase
affects activity increases activity
EXP
Hexachlorocyclohexane affects the activity of G6PD protein Hexachlorocyclohexane results in increased activity of G6PD protein
CTD
PMID:2461408 PMID:7535533 PMID:8519523
NCBI chr X:157,352,364...157,372,144
Ensembl chr X:152,201,098...152,220,801
G
Gabarapl2
GABA type A receptor associated protein like 2
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of GABARAPL2 mRNA
CTD
PMID:17785943
NCBI chr19:56,819,826...56,830,662
Ensembl chr19:39,910,534...39,924,628
G
Gabra1
gamma-aminobutyric acid type A receptor subunit alpha 1
multiple interactions increases expression
ISO EXP
Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] Hexachlorocyclohexane results in increased expression of GABRA1 mRNA
CTD
PMID:9316872 PMID:11156579 PMID:14637376 PMID:25572523
NCBI chr10:27,096,731...27,152,563
Ensembl chr10:26,595,160...26,650,864
G
Gabra2
gamma-aminobutyric acid type A receptor subunit alpha 2
multiple interactions
ISO
Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:14637376
NCBI chr14:37,451,218...37,587,458
Ensembl chr14:37,097,279...37,228,944
G
Gabra6
gamma-aminobutyric acid type A receptor subunit alpha6
multiple interactions
ISO
Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]
CTD
PMID:9316872
NCBI chr10:27,311,965...27,327,337
Ensembl chr10:26,810,423...26,825,769
G
Gabrb1
gamma-aminobutyric acid type A receptor subunit beta1
affects binding multiple interactions
ISO
Hexachlorocyclohexane binds to GABRB1 protein Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]
CTD
PMID:11156579 PMID:11489356
NCBI chr14:36,434,339...36,917,920
Ensembl chr14:36,080,393...36,548,948
G
Gabrb2
gamma-aminobutyric acid type A receptor subunit beta 2
multiple interactions
ISO
Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]
CTD
PMID:14637376
NCBI chr10:27,438,127...27,657,680
Ensembl chr10:26,936,551...27,151,251
G
Gabrb3
gamma-aminobutyric acid type A receptor subunit beta 3
affects binding multiple interactions
ISO
Hexachlorocyclohexane binds to GABRB3 protein Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to GABRB3 protein]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
CTD
PMID:9316872 PMID:11312652 PMID:11489356 PMID:16537435
NCBI chr 1:117,602,772...117,838,230
Ensembl chr 1:108,296,124...108,698,961
G
Gabrg2
gamma-aminobutyric acid type A receptor subunit gamma 2
multiple interactions
ISO
Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [1-(4-ethynylphenyl)-4-propyl-2,6,7-trioxabicyclo(2.2.2)octane binds to [GABRA2 protein binds to GABRB2 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [Pentobarbital results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
CTD
PMID:9316872 PMID:11156579 PMID:14637376
NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,374,694...26,464,346
G
Gabrr1
gamma-aminobutyric acid type A receptor subunit rho 1
affects binding
ISO
Hexachlorocyclohexane binds to GABRR1 protein
CTD
PMID:11879973
NCBI chr 5:52,320,475...52,357,549
Ensembl chr 5:47,524,151...47,561,228
G
Gata3
GATA binding protein 3
increases expression
ISO
Hexachlorocyclohexane results in increased expression of GATA3 mRNA
CTD
PMID:24356939
NCBI chr17:73,544,234...73,575,670
Ensembl chr17:68,643,873...68,665,391
G
Gck
glucokinase
increases expression
EXP
Hexachlorocyclohexane results in increased expression of GCK mRNA
CTD
PMID:17785943
NCBI chr14:84,999,019...85,041,098
Ensembl chr14:80,785,060...80,826,995
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
ISO
Hexachlorocyclohexane results in increased expression of GCLC mRNA
CTD
PMID:26198647
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
Hexachlorocyclohexane results in increased expression of GCLM mRNA
CTD
PMID:26198647
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535
G
Gfra1
GDNF family receptor alpha 1
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of GFRA1 mRNA
CTD
PMID:28263720
NCBI chr 1:267,325,297...267,557,037
Ensembl chr 1:257,321,742...257,551,473
G
Ggt1
gamma-glutamyltransferase 1
multiple interactions affects activity decreases activity increases activity
ISO EXP
Plant Extracts inhibits the reaction [Hexachlorocyclohexane results in increased activity of GGT1 protein] Hexachlorocyclohexane affects the activity of GGT1 protein Hexachlorocyclohexane results in decreased activity of GGT1 protein
CTD
PMID:8519523 PMID:9475050 PMID:11349524
NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442
G
Gja1
gap junction protein, alpha 1
affects localization increases expression decreases phosphorylation decreases expression increases degradation increases phosphorylation multiple interactions
ISO EXP
Hexachlorocyclohexane affects the localization of GJA1 protein Hexachlorocyclohexane results in increased expression of GJA1 protein Hexachlorocyclohexane results in decreased phosphorylation of GJA1 protein Hexachlorocyclohexane results in decreased expression of GJA1 mRNA; Hexachlorocyclohexane results in decreased expression of GJA1 protein Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form Hexachlorocyclohexane results in increased phosphorylation of GJA1 protein 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of GJA1 protein]; chaetoglobosins inhibits the reaction [Hexachlorocyclohexane results in decreased phosphorylation of GJA1 protein]; Chloroquine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form]; Colchicine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased phosphorylation of and affects the localization of GJA1 protein]; Hexachlorocyclohexane promotes the reaction [GJA1 protein binds to TJP1 protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane affects the localization of GJA1 protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of GJA1 protein]
CTD
PMID:7530866 PMID:8824497 PMID:11532877 PMID:12807735 PMID:15194225 PMID:15749814 PMID:18040759 PMID:35413382 More...
NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582
G
Glra1
glycine receptor, alpha 1
decreases activity
ISO
Hexachlorocyclohexane results in decreased activity of GLRA1 protein
CTD
PMID:22035056
NCBI chr10:40,128,284...40,228,612
Ensembl chr10:39,629,459...39,727,162
G
Glra2
glycine receptor, alpha 2
decreases activity
ISO
Hexachlorocyclohexane results in decreased activity of GLRA2 protein
CTD
PMID:22035056
NCBI chr X:32,651,931...32,873,277
Ensembl chr X:29,020,557...29,241,666
G
Glra3
glycine receptor, alpha 3
decreases activity
ISO
Hexachlorocyclohexane results in decreased activity of GLRA3 protein
CTD
PMID:22035056
NCBI chr16:39,210,534...39,857,332
Ensembl chr16:34,204,811...34,848,753
G
Glul
glutamate-ammonia ligase
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of GLUL mRNA
CTD
PMID:17785943
NCBI chr13:68,519,500...68,585,554
Ensembl chr13:66,025,630...66,035,108
G
Glyat
glycine-N-acyltransferase
affects expression
EXP
Hexachlorocyclohexane affects the expression of GLYAT mRNA
CTD
PMID:17785943
NCBI chr 1:219,128,798...219,149,615
Ensembl chr 1:209,704,268...209,724,942
G
Gna12
G protein subunit alpha 12
affects expression
EXP
Hexachlorocyclohexane affects the expression of GNA12 mRNA
CTD
PMID:17785943
NCBI chr12:18,919,629...19,000,185
Ensembl chr12:13,805,698...13,886,255
G
Gnrh1
gonadotropin releasing hormone 1
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with DDT] results in increased expression of GNRH1
CTD
PMID:16329587
NCBI chr15:46,147,878...46,152,086
Ensembl chr15:41,972,905...41,973,581 Ensembl chr15:41,972,905...41,973,581
G
Got1
glutamic-oxaloacetic transaminase 1
increases expression
EXP
Hexachlorocyclohexane results in increased expression of GOT1 mRNA
CTD
PMID:17785943
NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:242,357,306...242,380,633
G
Gpat3
glycerol-3-phosphate acyltransferase 3
increases expression
ISO
Hexachlorocyclohexane results in increased expression of GPAT3 mRNA
CTD
PMID:26198647
NCBI chr14:9,018,762...9,072,552
Ensembl chr14:8,714,373...8,766,490
G
Gpr18
G protein-coupled receptor 18
increases expression
ISO
Hexachlorocyclohexane results in increased expression of GPR18 mRNA
CTD
PMID:23824090 PMID:24356939
NCBI chr15:105,404,062...105,407,812
Ensembl chr15:98,997,259...99,001,470
G
Gpt
glutamic--pyruvic transaminase
multiple interactions increases activity
EXP
[Hexachlorocyclohexane co-treated with isoproturon] results in increased activity of GPT protein Hexachlorocyclohexane results in increased activity of GPT protein
CTD
PMID:11180283
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
G
Gpt2
glutamic--pyruvic transaminase 2
increases expression
ISO
Hexachlorocyclohexane results in increased expression of GPT2 mRNA
CTD
PMID:24356939
NCBI chr19:37,700,023...37,734,551
Ensembl chr19:21,517,621...21,560,610
G
Gsr
glutathione-disulfide reductase
multiple interactions increases expression decreases activity increases activity
ISO EXP
[Hexachlorocyclohexane co-treated with Malathion] results in decreased activity of GSR protein; [Hexachlorocyclohexane co-treated with Permethrin] results in decreased activity of GSR protein; Plant Extracts inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein] Hexachlorocyclohexane results in increased expression of GSR mRNA Hexachlorocyclohexane results in increased activity of GSR protein [Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of GSR protein; [Hexachlorocyclohexane co-treated with Dichlorvos co-treated with Plant Extracts] results in decreased activity of GSR protein; [Hexachlorocyclohexane co-treated with Dichlorvos] results in decreased activity of GSR protein; [Phenobarbital co-treated with Hexachlorocyclohexane] results in increased activity of GSR protein; Curcumin inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]; Plant Extracts inhibits the reaction [Hexachlorocyclohexane results in decreased activity of GSR protein]
CTD
PMID:1716606 PMID:9704597 PMID:10817630 PMID:11349524 PMID:11404799 PMID:11561191 PMID:16046044 PMID:16718366 PMID:21976817 PMID:22224058 PMID:26198647 More...
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
G
Gsta2
glutathione S-transferase alpha 2
affects expression
EXP
Hexachlorocyclohexane affects the expression of GSTA2 mRNA
CTD
PMID:22001173
NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:79,184,322...79,196,798
G
Gsta5
glutathione S-transferase alpha 5
increases expression
EXP
Hexachlorocyclohexane results in increased expression of GSTA5 mRNA
CTD
PMID:17785943
NCBI chr 8:87,985,768...87,997,766
Ensembl chr 8:79,105,661...79,117,472
G
Gusb
glucuronidase, beta
affects activity
EXP
Hexachlorocyclohexane affects the activity of GUSB protein
CTD
PMID:8519523
NCBI chr12:32,337,281...32,350,838
Ensembl chr12:26,697,951...26,726,905
G
Hbe2
hemoglobin, epsilon 2
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of HBG2 protein
CTD
PMID:7512143
NCBI chr 1:167,691,174...167,692,802
Ensembl chr 1:158,279,285...158,280,913
G
Hmgcs1
3-hydroxy-3-methylglutaryl-CoA synthase 1
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of HMGCS1 mRNA
CTD
PMID:24356939
NCBI chr 2:53,379,457...53,399,807
Ensembl chr 2:51,649,497...51,667,100
G
Hnf4a
hepatocyte nuclear factor 4, alpha
affects expression
EXP
Hexachlorocyclohexane affects the expression of HNF4A mRNA
CTD
PMID:17785943
NCBI chr 3:172,606,220...172,667,758
Ensembl chr 3:152,186,787...152,248,320
G
Hpd
4-hydroxyphenylpyruvate dioxygenase
increases expression
EXP
Hexachlorocyclohexane results in increased expression of HPD mRNA
CTD
PMID:17785943
NCBI chr12:39,042,246...39,053,596
Ensembl chr12:33,381,231...33,392,766
G
Hprt1
hypoxanthine phosphoribosyltransferase 1
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of HPRT1 mRNA
CTD
PMID:17785943
NCBI chr X:137,655,744...137,687,718
Ensembl chr X:132,736,096...132,768,154
G
Hsd17b1
hydroxysteroid (17-beta) dehydrogenase 1
decreases activity
EXP
Hexachlorocyclohexane results in decreased activity of HSD17B1 protein
CTD
PMID:11404799
NCBI chr10:86,510,011...86,512,211
Ensembl chr10:86,009,728...86,011,927
G
Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
decreases activity
EXP
Hexachlorocyclohexane results in decreased activity of HSD3B1 protein
CTD
PMID:11404799
NCBI chr 2:188,858,574...188,864,694
Ensembl chr 2:186,169,863...186,175,999
G
Hsd3b2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
multiple interactions decreases expression
ISO
Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA] Hexachlorocyclohexane results in decreased expression of HSD3B2 mRNA
CTD
PMID:17080404
NCBI chr 2:188,784,614...188,812,535
Ensembl chr 2:186,095,897...186,101,852
G
Hspa1a
heat shock protein family A (Hsp70) member 1A
affects localization
ISO
Hexachlorocyclohexane affects the localization of HSPA1A protein
CTD
PMID:12919956
NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227
G
Hspa4
heat shock protein family A (Hsp70) member 4
increases expression
EXP
Hexachlorocyclohexane results in increased expression of HSPA4 protein
CTD
PMID:30248393
NCBI chr10:37,908,866...37,951,994
Ensembl chr10:37,408,025...37,449,001
G
Htr2a
5-hydroxytryptamine receptor 2A
increases expression
EXP
Hexachlorocyclohexane results in increased expression of HTR2A mRNA
CTD
PMID:25572523
NCBI chr15:56,360,647...56,428,703
Ensembl chr15:49,950,804...50,020,928
G
Hyls1
HYLS1, centriolar and ciliogenesis associated
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of HYLS1 mRNA
CTD
PMID:24356939
NCBI chr 8:42,170,505...42,179,573
Ensembl chr 8:33,912,692...33,921,760
G
Id1
inhibitor of DNA binding 1
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of ID1 mRNA
CTD
PMID:24356939
NCBI chr 3:161,671,525...161,672,691
Ensembl chr 3:141,211,267...141,212,419
G
Idh1
isocitrate dehydrogenase (NADP(+)) 1
affects expression
EXP
Hexachlorocyclohexane affects the expression of IDH1 mRNA
CTD
PMID:17785943
NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:66,534,146...66,563,708
G
Ier3
immediate early response 3
increases expression
ISO
Hexachlorocyclohexane results in increased expression of IER3 mRNA
CTD
PMID:24356939
NCBI chr20:2,933,173...2,934,377
Ensembl chr20:2,928,378...2,929,583
G
Ifng
interferon gamma
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of IFNG protein
CTD
PMID:15319175
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
G
Igf1
insulin-like growth factor 1
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of IGF1 mRNA
CTD
PMID:17785943
NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296
G
Il1a
interleukin 1 alpha
multiple interactions increases expression
EXP
alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A protein]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A mRNA]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A protein] Hexachlorocyclohexane results in increased expression of IL1A mRNA; Hexachlorocyclohexane results in increased expression of IL1A protein
CTD
PMID:15025948
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
G
Il5
interleukin 5
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of IL5 protein
CTD
PMID:15319175
NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213
G
Irs1
insulin receptor substrate 1
decreases phosphorylation
EXP
Hexachlorocyclohexane results in decreased phosphorylation of IRS1 protein
CTD
PMID:30248393
NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122
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Isl2
ISL LIM homeobox 2
increases expression
ISO
Hexachlorocyclohexane results in increased expression of ISL2 mRNA
CTD
PMID:24356939
NCBI chr 8:64,819,879...64,824,864
Ensembl chr 8:55,923,805...55,928,790
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases phosphorylation multiple interactions
ISO EXP
Hexachlorocyclohexane results in increased phosphorylation of JUN protein Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of JUN protein
CTD
PMID:15888667 PMID:23927878
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
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Kif21b
kinesin family member 21B
increases expression
ISO
Hexachlorocyclohexane results in increased expression of KIF21B mRNA
CTD
PMID:24356939
NCBI chr13:50,127,842...50,177,822
Ensembl chr13:47,576,160...47,626,127
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Kit
KIT proto-oncogene receptor tyrosine kinase
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of KIT mRNA
CTD
PMID:28263720
NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,548,877...32,624,652
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Klf9
KLF transcription factor 9
increases expression
EXP
Hexachlorocyclohexane results in increased expression of KLF9 mRNA
CTD
PMID:17785943
NCBI chr 1:230,126,646...230,151,641
Ensembl chr 1:220,700,108...220,725,037
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Klhl24
kelch-like family member 24
increases expression
ISO
Hexachlorocyclohexane results in increased expression of KLHL24 mRNA
CTD
PMID:24356939
NCBI chr11:94,348,024...94,382,085
Ensembl chr11:80,846,755...80,877,636
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Ldha
lactate dehydrogenase A
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of LDHA protein
CTD
PMID:6164129
NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472
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Ldhb
lactate dehydrogenase B
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of LDHB protein
CTD
PMID:6164129
NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:175,428,385...175,446,403
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Lep
leptin
affects expression
EXP
Hexachlorocyclohexane affects the expression of LEP mRNA
CTD
PMID:17785943
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
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Lhcgr
luteinizing hormone/choriogonadotropin receptor
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of LHCGR protein
CTD
PMID:11250058
NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:5,661,871...5,724,521
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Lif
LIF, interleukin 6 family cytokine
increases expression
ISO
Hexachlorocyclohexane results in increased expression of LIF mRNA
CTD
PMID:26198647
NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482
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Lrrc2
leucine rich repeat containing 2
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of LRRC2 mRNA
CTD
PMID:28263720
NCBI chr 8:119,814,514...119,847,587
Ensembl chr 8:110,938,165...110,969,185
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Lyve1
lymphatic vessel endothelial hyaluronan receptor 1
increases expression
EXP
Hexachlorocyclohexane results in increased expression of XLKD1 mRNA
CTD
PMID:17785943
NCBI chr 1:174,393,387...174,410,977
Ensembl chr 1:164,962,872...164,976,309
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Map1lc3b
microtubule-associated protein 1 light chain 3 beta
increases expression
EXP
Hexachlorocyclohexane results in increased expression of MAP1LC3B mRNA
CTD
PMID:17785943
NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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Map2
microtubule-associated protein 2
multiple interactions
ISO
Hexachlorocyclohexane promotes the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of MAP2 mRNA]
CTD
PMID:32949729
NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:67,723,371...67,979,809
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Map2k1
mitogen activated protein kinase kinase 1
multiple interactions
ISO
Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAP2K1 protein
CTD
PMID:15888667
NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147
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Map2k2
mitogen activated protein kinase kinase 2
multiple interactions
ISO
Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAP2K2 protein
CTD
PMID:15888667
NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:8,580,905...8,610,243
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Map4k4
mitogen-activated protein kinase kinase kinase kinase 4
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of MAP4K4 mRNA
CTD
PMID:17785943
NCBI chr 9:49,696,573...49,822,353
Ensembl chr 9:42,200,278...42,326,698
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Mapk1
mitogen activated protein kinase 1
multiple interactions increases phosphorylation
ISO EXP
calphostin C inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; AG 1879 inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK1 protein]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in increased phosphorylation of MAPK1 protein]; Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK1 protein
CTD
PMID:12807735 PMID:15888667 PMID:16818664 PMID:18040759 PMID:21278053
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
multiple interactions increases phosphorylation
ISO EXP
calphostin C inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; geldanamycin inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein] 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; AG 1879 inhibits the reaction [Hexachlorocyclohexane results in increased phosphorylation of MAPK3 protein]; Hexachlorocyclohexane inhibits the reaction [Estradiol results in increased phosphorylation of MAPK3 protein]; Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK3 protein
CTD
PMID:12807735 PMID:15888667 PMID:16818664 PMID:18040759 PMID:21278053 PMID:23927878 More...
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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Mapk8
mitogen-activated protein kinase 8
multiple interactions
EXP
Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK8 protein
CTD
PMID:23927878
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
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Mapk9
mitogen-activated protein kinase 9
multiple interactions
EXP
Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK9 protein
CTD
PMID:23927878
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178
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Mbp
myelin basic protein
decreases expression affects expression
EXP
Hexachlorocyclohexane results in decreased expression of MBP protein Hexachlorocyclohexane affects the expression of MBP mRNA
CTD
PMID:1701514 PMID:22954530
NCBI chr18:78,130,652...78,241,174
Ensembl chr18:75,855,878...75,966,404
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Mbtps2
membrane-bound transcription factor peptidase, site 2
increases expression
EXP
Hexachlorocyclohexane results in increased expression of MBTPS2 mRNA
CTD
PMID:17785943
NCBI chr X:41,225,956...41,290,030
Ensembl chr X:37,410,811...37,464,430
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Meox2
mesenchyme homeobox 2
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of MEOX2 mRNA
CTD
PMID:17785943
NCBI chr 6:59,584,025...59,644,722
Ensembl chr 6:53,856,758...53,917,467
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Mertk
MER proto-oncogene, tyrosine kinase
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of MERTK mRNA
CTD
PMID:28263720
NCBI chr 3:136,391,936...136,498,366
Ensembl chr 3:115,939,351...116,046,554
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Mpo
myeloperoxidase
multiple interactions increases activity
EXP
[Hexachlorocyclohexane co-treated with Iron] results in increased activity of MPO protein; [Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased activity of MPO protein Hexachlorocyclohexane results in increased activity of MPO protein
CTD
PMID:7503757 PMID:11141352
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
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Msh2
mutS homolog 2
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of MSH2 mRNA
CTD
PMID:17785943
NCBI chr 6:12,567,368...12,626,534
Ensembl chr 6:6,813,795...6,872,938
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Mt1
metallothionein 1
increases expression
EXP
Hexachlorocyclohexane results in increased expression of MT1A mRNA
CTD
PMID:17785943
NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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Mtch2
mitochondrial carrier 2
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of MTCH2 mRNA
CTD
PMID:17785943
NCBI chr 3:97,286,388...97,306,028
Ensembl chr 3:76,830,413...76,850,189
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Mthfd2
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
increases expression
ISO
Hexachlorocyclohexane results in increased expression of MTHFD2 mRNA
CTD
PMID:24356939
NCBI chr 4:117,368,833...117,380,350
Ensembl chr 4:115,811,139...115,822,608
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Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of MYC mRNA
CTD
PMID:17785943
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
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Myh3
myosin heavy chain 3
affects expression
EXP
Hexachlorocyclohexane affects the expression of MYH3 mRNA
CTD
PMID:17785943
NCBI chr10:52,269,185...52,293,000
Ensembl chr10:51,770,177...51,793,992
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Nanos1
nanos C2HC-type zinc finger 1
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of NANOS1 mRNA
CTD
PMID:24356939
NCBI chr 1:269,883,713...269,887,611
Ensembl chr 1:259,897,939...259,898,730
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Ncoa7
nuclear receptor coactivator 7
increases expression
ISO
Hexachlorocyclohexane results in increased expression of NCOA7 mRNA
CTD
PMID:24356939
NCBI chr 1:28,674,614...28,835,891
Ensembl chr 1:26,856,530...27,015,871
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Nfe2l2
NFE2 like bZIP transcription factor 2
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of NFE2L2 mRNA
CTD
PMID:17785943
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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Nfe2l3
NFE2 like bZIP transcription factor 3
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of NFE2L3 mRNA
CTD
PMID:24356939
NCBI chr 4:81,837,404...81,865,258
Ensembl chr 4:80,506,756...80,534,629
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Nfia
nuclear factor I/A
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of NFIA mRNA
CTD
PMID:17785943
NCBI chr 5:117,359,006...117,897,391
Ensembl chr 5:112,436,644...112,775,885
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Nfib
nuclear factor I/B
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of NFIB mRNA
CTD
PMID:17785943
NCBI chr 5:101,805,168...102,020,618
Ensembl chr 5:96,764,653...96,975,479
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Nfix
nuclear factor I X
increases expression
EXP
Hexachlorocyclohexane results in increased expression of NFIX mRNA
CTD
PMID:17785943
NCBI chr19:40,259,873...40,356,966
Ensembl chr19:23,355,498...23,448,265
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions increases phosphorylation increases activity
EXP
alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased activity of NFKB1 protein]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased activity of NFKB1 protein]; Hexachlorocyclohexane affects the reaction [Triiodothyronine results in increased activity of NFKB1 protein] Hexachlorocyclohexane results in increased phosphorylation of NFKB1 protein
CTD
PMID:15019085 PMID:15025948
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia
NFKB inhibitor alpha
increases phosphorylation
EXP
Hexachlorocyclohexane results in increased phosphorylation of NFKBIA protein
CTD
PMID:30248393
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
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Nipbl
NIPBL, cohesin loading factor
increases expression
EXP
Hexachlorocyclohexane results in increased expression of NIPBL mRNA
CTD
PMID:17785943
NCBI chr 2:59,126,676...59,314,841
Ensembl chr 2:57,399,445...57,565,899
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Nop58
NOP58 ribonucleoprotein
increases expression
EXP
Hexachlorocyclohexane results in increased expression of NOL5 mRNA
CTD
PMID:17785943
NCBI chr 9:68,614,992...68,638,911
Ensembl chr 9:61,120,929...61,144,810
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Nos2
nitric oxide synthase 2
increases expression
ISO
Hexachlorocyclohexane results in increased expression of NOS2 protein
CTD
PMID:23777605
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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Nox1
NADPH oxidase 1
multiple interactions
EXP
[Hexachlorocyclohexane co-treated with Dieldrin] results in decreased expression of NOX1 protein
CTD
PMID:30240590
NCBI chr X:101,572,338...101,625,571
Ensembl chr X:97,279,056...97,302,236
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Nr0b2
nuclear receptor subfamily 0, group B, member 2
increases expression
EXP
Hexachlorocyclohexane results in increased expression of NR0B2 mRNA
CTD
PMID:17785943
NCBI chr 5:151,063,160...151,066,475
Ensembl chr 5:145,779,294...145,782,609
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions increases expression increases activity
EXP ISO
Hexachlorocyclohexane binds to and results in increased activity of NR1I2 protein Hexachlorocyclohexane results in increased expression of NR1I2 mRNA Hexachlorocyclohexane results in increased activity of NR1I2 protein
CTD
PMID:14613717 PMID:15548381 PMID:16054614 PMID:25572523 PMID:25680588
NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
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Nr1i3
nuclear receptor subfamily 1, group I, member 3
increases expression increases activity
EXP ISO
Hexachlorocyclohexane results in increased expression of NR1I3 mRNA Hexachlorocyclohexane results in increased activity of NR1I3 protein
CTD
PMID:25572523 PMID:28927721
NCBI chr13:86,165,327...86,170,362
Ensembl chr13:83,632,899...83,637,906
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Nr2f6
nuclear receptor subfamily 2, group F, member 6
affects expression
EXP
Hexachlorocyclohexane affects the expression of NR2F6 mRNA
CTD
PMID:17785943
NCBI chr16:18,046,012...18,053,914
Ensembl chr16:18,046,013...18,053,459
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Nr3c1
nuclear receptor subfamily 3, group C, member 1
increases expression
EXP
Hexachlorocyclohexane results in increased expression of NR3C1 mRNA
CTD
PMID:17785943
NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,271,681...31,393,375
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Nr4a2
nuclear receptor subfamily 4, group A, member 2
increases expression
EXP
Hexachlorocyclohexane results in increased expression of NR4A2 mRNA
CTD
PMID:8737662
NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:41,689,851...41,697,877
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Nrf1
nuclear respiratory factor 1
increases expression
ISO
Hexachlorocyclohexane results in increased expression of NRF1 mRNA
CTD
PMID:23777605
NCBI chr 4:59,632,366...59,738,166
Ensembl chr 4:58,664,957...58,825,328
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Ntrk1
neurotrophic receptor tyrosine kinase 1
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK1 mRNA
CTD
PMID:28263720
NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:173,236,963...173,253,770
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Ntrk2
neurotrophic receptor tyrosine kinase 2
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of NTRK2 mRNA
CTD
PMID:28263720
NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136
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Odc1
ornithine decarboxylase 1
multiple interactions increases activity increases expression
EXP
Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased activity of ODC1 protein]; Diazepam inhibits the reaction [Hexachlorocyclohexane results in increased expression of ODC1 mRNA]
CTD
PMID:1710164
NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:40,329,964...40,336,440
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Ogt
O-linked N-acetylglucosamine (GlcNAc) transferase
increases expression
EXP
Hexachlorocyclohexane results in increased expression of OGT mRNA
CTD
PMID:17785943
NCBI chr X:70,811,317...70,856,123
Ensembl chr X:66,771,349...66,816,146
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Onecut1
one cut homeobox 1
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of ONECUT1 mRNA
CTD
PMID:17785943
NCBI chr 8:84,480,066...84,507,848
Ensembl chr 8:75,599,740...75,627,277
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Otx2
orthodenticle homeobox 2
multiple interactions
ISO
Hexachlorocyclohexane inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of OTX2 mRNA]
CTD
PMID:32949729
NCBI chr15:24,422,876...24,432,709
Ensembl chr15:21,943,191...21,953,416
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P4ha1
prolyl 4-hydroxylase subunit alpha 1
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of P4HA1 mRNA
CTD
PMID:17785943
NCBI chr20:27,784,696...27,895,785
Ensembl chr20:27,302,141...27,352,786
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Park7
Parkinsonism associated deglycase
decreases activity
ISO
Hexachlorocyclohexane results in decreased activity of PARK7 protein
CTD
PMID:36842454
NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970
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Pax6
paired box 6
multiple interactions
ISO
Hexachlorocyclohexane inhibits the reaction [[4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide co-treated with LDN 193189] results in increased expression of PAX6 mRNA]
CTD
PMID:32949729
NCBI chr 3:112,590,034...112,611,771
Ensembl chr 3:92,135,637...92,157,014
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Pdcd4
programmed cell death 4
increases expression
ISO
Hexachlorocyclohexane results in increased expression of PDCD4 mRNA
CTD
PMID:24356939
NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:252,921,392...252,944,275
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Pdgfrb
platelet derived growth factor receptor beta
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA
CTD
PMID:28263720
NCBI chr18:56,770,348...56,809,228
Ensembl chr18:54,499,964...54,538,843
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Pdlim1
PDZ and LIM domain 1
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of PDLIM1 mRNA
CTD
PMID:17785943
NCBI chr 1:248,991,818...249,040,409
Ensembl chr 1:239,042,385...239,091,076
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Peli1
pellino E3 ubiquitin protein ligase 1
increases expression
ISO
Hexachlorocyclohexane results in increased expression of PELI1 mRNA
CTD
PMID:24356939
NCBI chr14:99,455,970...99,510,474
Ensembl chr14:95,254,589...95,308,285 Ensembl chr 1:95,254,589...95,308,285
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Per2
period circadian regulator 2
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of PER2 mRNA
CTD
PMID:17785943
NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:92,007,296...92,049,459
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Pgd
phosphogluconate dehydrogenase
affects activity
EXP
Hexachlorocyclohexane affects the activity of PGD protein
CTD
PMID:7535533
NCBI chr 5:164,865,830...164,882,029
Ensembl chr 5:159,561,271...159,742,778
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Pgr
progesterone receptor
affects binding multiple interactions
ISO
Hexachlorocyclohexane binds to PGR protein [Progesterone co-treated with Hexachlorocyclohexane] results in decreased expression of PGR mRNA; Hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]; Hexachlorocyclohexane inhibits the reaction [Progesterone binds to PGR protein]
CTD
PMID:9144411 PMID:14579009 PMID:26022396
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
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Pigr
polymeric immunoglobulin receptor
increases expression
EXP
Hexachlorocyclohexane results in increased expression of PIGR mRNA
CTD
PMID:17785943
NCBI chr13:44,851,001...44,879,143
Ensembl chr13:42,298,914...42,326,875
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Pja2
praja ring finger ubiquitin ligase 2
increases expression
EXP
Hexachlorocyclohexane results in increased expression of PJA2 mRNA
CTD
PMID:17785943
NCBI chr 9:111,403,624...111,453,703
Ensembl chr 9:103,956,678...104,006,783
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Plaat5
phospholipase A and acyltransferase 5
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of PLAAT5 mRNA
CTD
PMID:17785943
NCBI chr 1:204,847,600...204,878,456
Ensembl chr 1:204,847,600...204,878,184
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Plcl1
phospholipase C-like 1
increases expression
ISO
Hexachlorocyclohexane results in increased expression of PLCL1 mRNA
CTD
PMID:24356939
NCBI chr 9:64,395,976...64,733,171
Ensembl chr 9:56,901,534...57,238,782
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Plpp3
phospholipid phosphatase 3
increases expression
EXP
Hexachlorocyclohexane results in increased expression of PLPP3 mRNA
CTD
PMID:17785943
NCBI chr 5:125,156,000...125,231,119
Ensembl chr 5:119,927,085...120,002,205
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Plxnd1
plexin D1
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of PLXND1 mRNA
CTD
PMID:28263720
NCBI chr 4:150,675,377...150,715,706
Ensembl chr 4:149,002,784...149,043,244
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Pnrc1
proline-rich nuclear receptor coactivator 1
increases expression
ISO
Hexachlorocyclohexane results in increased expression of PNRC1 mRNA
CTD
PMID:24356939
NCBI chr 5:52,443,400...52,489,303
Ensembl chr 5:47,647,071...47,650,161
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Polg2
DNA polymerase gamma 2, accessory subunit
increases expression
EXP
Hexachlorocyclohexane results in increased expression of POLG2 mRNA
CTD
PMID:17785943
NCBI chr10:92,212,303...92,222,849
Ensembl chr10:91,712,586...91,723,008
G
Pomc
proopiomelanocortin
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with DDT] results in increased expression of POMC
CTD
PMID:16329587
NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664
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Por
cytochrome p450 oxidoreductase
increases expression
EXP
Hexachlorocyclohexane results in increased expression of POR mRNA
CTD
PMID:17785943
NCBI chr12:26,587,674...26,655,612
Ensembl chr12:20,951,058...20,999,245
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Ppargc1a
PPARG coactivator 1 alpha
increases expression
ISO
Hexachlorocyclohexane results in increased expression of PPARGC1A mRNA
CTD
PMID:23777605
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
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Ppp2r2b
protein phosphatase 2, regulatory subunit B, beta
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of PPP2R2B mRNA
CTD
PMID:17785943
NCBI chr18:34,904,686...35,357,299
Ensembl chr18:34,653,721...35,081,025
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Pprc1
PPARG related coactivator 1
increases expression
ISO
Hexachlorocyclohexane results in increased expression of PPRC1 mRNA
CTD
PMID:23777605
NCBI chr 1:254,851,136...254,867,570
Ensembl chr 1:244,902,179...244,918,587
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Prkacb
protein kinase cAMP-activated catalytic subunit beta
affects expression
EXP
Hexachlorocyclohexane affects the expression of PRKACB mRNA
CTD
PMID:17785943
NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:235,636,885...235,726,198
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Prkch
protein kinase C, eta
affects expression
EXP
Hexachlorocyclohexane affects the expression of PRKCH mRNA
CTD
PMID:22001173
NCBI chr 6:98,027,830...98,226,486
Ensembl chr 6:92,292,000...92,490,654
G
Prxl2b
peroxiredoxin like 2B
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of PRXL2B mRNA
CTD
PMID:24356939
NCBI chr 5:170,744,953...170,747,556
G
Psmb3
proteasome 20S subunit beta 3
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of PSMB3 mRNA
CTD
PMID:17785943
NCBI chr10:83,193,787...83,200,883
Ensembl chr10:82,697,425...82,704,521
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions increases expression
EXP
Hexachlorocyclohexane results in increased expression of and results in increased activity of PTGS2 protein Hexachlorocyclohexane results in increased expression of PTGS2 mRNA; Hexachlorocyclohexane results in increased expression of PTGS2 protein
CTD
PMID:10426785
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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Ptp4a1
protein tyrosine phosphatase 4A1
increases expression
EXP
Hexachlorocyclohexane results in increased expression of PTP4A1 mRNA
CTD
PMID:17785943
NCBI chr 9:40,710,250...40,718,176
Ensembl chr 9:33,214,208...33,221,964
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Rab14
RAB14, member RAS oncogene family
increases expression
EXP
Hexachlorocyclohexane results in increased expression of RAB14 mRNA
CTD
PMID:17785943
NCBI chr 3:38,899,430...38,920,572
Ensembl chr 3:18,501,963...18,523,172
G
Rab34
RAB34, member RAS oncogene family
affects expression
EXP
Hexachlorocyclohexane affects the expression of RAB34 mRNA
CTD
PMID:17785943
NCBI chr10:63,581,542...63,585,608
Ensembl chr10:63,083,338...63,087,538
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Rad23a
RAD23 homolog A, nucleotide excision repair protein
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of RAD23A mRNA
CTD
PMID:17785943
NCBI chr19:40,219,235...40,225,543
Ensembl chr19:23,314,797...23,320,695
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Raf1
Raf-1 proto-oncogene, serine/threonine kinase
multiple interactions
ISO
Hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of RAF1 protein
CTD
PMID:15888667
NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317
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Rala
RAS like proto-oncogene A
increases expression
EXP
Hexachlorocyclohexane results in increased expression of RALA mRNA
CTD
PMID:17785943
NCBI chr17:51,787,682...51,840,738
Ensembl chr17:47,092,207...47,144,063
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Ralgapa1
Ral GTPase activating protein catalytic subunit alpha 1
increases expression
EXP
Hexachlorocyclohexane results in increased expression of RALGAPA1 mRNA
CTD
PMID:17785943
NCBI chr 6:78,712,554...78,987,486
Ensembl chr 6:72,977,432...73,252,378
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Rara
retinoic acid receptor, alpha
increases activity
ISO
Hexachlorocyclohexane results in increased activity of RARA protein
CTD
PMID:20143881
NCBI chr10:84,379,780...84,424,371
Ensembl chr10:83,893,384...83,928,142
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Rb1
RB transcriptional corepressor 1
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of RB1 mRNA
CTD
PMID:17785943
NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
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Rbm10
RNA binding motif protein 10
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of RBM10 mRNA
CTD
PMID:17785943
NCBI chr X:4,093,914...4,126,060
Ensembl chr X:1,540,398...1,572,575
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions increases activity increases phosphorylation affects localization
EXP
alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased activity of RELA protein]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased activity of RELA protein]; Hexachlorocyclohexane affects the reaction [Triiodothyronine results in increased activity of RELA protein] Hexachlorocyclohexane results in increased phosphorylation of RELA protein Hexachlorocyclohexane affects the localization of RELA protein
CTD
PMID:15019085 PMID:15025948 PMID:19038305
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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Ret
ret proto-oncogene
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in decreased expression of RET mRNA
CTD
PMID:28263720
NCBI chr 4:152,998,344...153,040,556
Ensembl chr 4:151,326,431...151,368,176
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Rgs2
regulator of G-protein signaling 2
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of RGS2 mRNA
CTD
PMID:24356939
NCBI chr13:58,350,063...58,352,666
Ensembl chr13:55,798,829...55,802,385
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Rnpep
arginyl aminopeptidase
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of RNPEP mRNA
CTD
PMID:17785943
NCBI chr13:49,251,259...49,271,440
Ensembl chr13:46,699,463...46,717,998
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Rps15
ribosomal protein S15
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of RPS15 mRNA
CTD
PMID:17785943
NCBI chr 7:10,066,572...10,068,167
Ensembl chr 7:9,416,004...9,417,450 Ensembl chr 7:9,416,004...9,417,450
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Rsad2
radical S-adenosyl methionine domain containing 2
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of RSAD2 mRNA
CTD
PMID:17785943
NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:43,047,658...43,059,699
G
Rxra
retinoid X receptor alpha
affects expression
EXP
Hexachlorocyclohexane affects the expression of RXRA mRNA
CTD
PMID:17785943
NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:10,989,832...11,073,712
G
Rxrb
retinoid X receptor beta
increases activity
ISO
Hexachlorocyclohexane results in increased activity of RXRB protein
CTD
PMID:18207673
NCBI chr20:4,818,707...4,824,968
Ensembl chr20:4,816,815...4,828,773
G
Rxrg
retinoid X receptor gamma
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of RXRG mRNA
CTD
PMID:17785943
NCBI chr13:82,276,330...82,318,097
Ensembl chr13:79,743,563...79,785,167
G
Scd
stearoyl-CoA desaturase
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of SCD1 mRNA
CTD
PMID:17785943
NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
G
Sdc4
syndecan 4
increases expression
EXP
Hexachlorocyclohexane results in increased expression of SDC4 mRNA
CTD
PMID:17785943
NCBI chr 3:173,574,239...173,592,923
Ensembl chr 3:153,154,896...153,173,580
G
Sec22a
SEC22 homolog A, vesicle trafficking protein
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of SEC22A mRNA
CTD
PMID:17785943
NCBI chr11:78,907,552...78,967,575
Ensembl chr11:65,402,684...65,462,319
G
Sec31a
SEC31 homolog A, COPII coat complex component
increases expression
EXP
Hexachlorocyclohexane results in increased expression of SEC31A mRNA
CTD
PMID:17785943
NCBI chr14:9,214,324...9,269,281
Ensembl chr14:9,214,349...9,269,273
G
Sema3g
semaphorin 3G
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of SEMA3G mRNA
CTD
PMID:24356939
NCBI chr16:6,420,025...6,431,655
Ensembl chr16:6,413,589...6,425,221
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Serinc3
serine incorporator 3
affects expression
EXP
Hexachlorocyclohexane affects the expression of SERINC3 mRNA
CTD
PMID:17785943
NCBI chr 3:152,301,882...152,321,327
Ensembl chr 3:152,301,772...152,321,808
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Serpine2
serpin family E member 2
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of SERPINE2 mRNA
CTD
PMID:17785943
NCBI chr 9:88,573,138...88,637,252
Ensembl chr 9:81,124,804...81,188,826
G
Sesn2
sestrin 2
increases expression
ISO
Hexachlorocyclohexane results in increased expression of SESN2 mRNA
CTD
PMID:24356939
NCBI chr 5:149,986,304...150,005,255
Ensembl chr 5:144,701,530...144,721,260
G
Sgk1
serum/glucocorticoid regulated kinase 1
decreases expression increases expression
EXP ISO
Hexachlorocyclohexane results in decreased expression of SGK1 mRNA Hexachlorocyclohexane results in increased expression of SGK1 mRNA
CTD
PMID:17785943 PMID:24356939
NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:22,980,261...23,098,283
G
Shbg
sex hormone binding globulin
multiple interactions decreases expression
ISO EXP
Hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to SHBG protein] Hexachlorocyclohexane results in decreased expression of SHBG protein
CTD
PMID:9171990 PMID:18248869
NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,332,941...54,351,057
G
Si
sucrase-isomaltase
decreases activity
EXP
Hexachlorocyclohexane results in decreased activity of SI protein
CTD
PMID:92405
NCBI chr 2:159,804,568...159,884,902
Ensembl chr 2:157,506,342...157,585,260
G
Slc10a1
solute carrier family 10 member 1
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of SLC10A1 mRNA
CTD
PMID:24464585
NCBI chr 6:106,344,319...106,357,944
Ensembl chr 6:100,613,045...100,626,670
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Slc11a2
solute carrier family 11 member 2
increases expression
EXP
Hexachlorocyclohexane results in increased expression of SLC11A2 mRNA
CTD
PMID:17785943
NCBI chr 7:133,381,878...133,429,921
Ensembl chr 7:131,503,081...131,540,145
G
Slc22a1
solute carrier family 22 member 1
decreases activity
ISO
Hexachlorocyclohexane results in decreased activity of SLC22A1 protein
CTD
PMID:24464585
NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678
G
Slc22a25
solute carrier family 22, member 25
affects expression
EXP
Hexachlorocyclohexane affects the expression of SLC22A9 mRNA
CTD
PMID:17785943
NCBI chr 1:214,767,837...214,956,535
Ensembl chr 1:205,338,699...205,433,085
G
Slc25a30
solute carrier family 25, member 30
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of SLC25A30 mRNA
CTD
PMID:17785943
NCBI chr15:57,486,346...57,508,981
Ensembl chr15:51,077,002...51,099,613
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Slc3a2
solute carrier family 3 member 2
increases expression
ISO
Hexachlorocyclohexane results in increased expression of SLC3A2 mRNA
CTD
PMID:24356939
NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:205,604,468...205,618,931
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Slc4a4
solute carrier family 4 member 4
increases expression
EXP
Hexachlorocyclohexane results in increased expression of SLC4A4 mRNA
CTD
PMID:17785943
NCBI chr14:19,125,394...19,577,379
Ensembl chr14:18,845,159...19,272,883
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Slc7a11
solute carrier family 7 member 11
increases expression
ISO
Hexachlorocyclohexane results in increased expression of SLC7A11 mRNA
CTD
PMID:24356939 PMID:26198647
NCBI chr 2:136,532,912...136,668,560
Ensembl chr 2:133,963,107...134,517,536
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Slc7a2
solute carrier family 7 member 2
increases expression
EXP
Hexachlorocyclohexane results in increased expression of SLC7A2 mRNA
CTD
PMID:17785943
NCBI chr16:58,115,991...58,174,256
Ensembl chr16:51,417,493...51,470,784
G
Snai2
snail family transcriptional repressor 2
affects expression
EXP
Hexachlorocyclohexane affects the expression of SNAI2 mRNA
CTD
PMID:17785943
NCBI chr11:99,686,934...99,690,349
Ensembl chr11:86,181,909...86,186,200
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Snrnp70
small nuclear ribonucleoprotein U1 subunit 70
increases expression
EXP
Hexachlorocyclohexane results in increased expression of SNRNP70 mRNA
CTD
PMID:17785943
NCBI chr 1:104,992,518...105,012,851
Ensembl chr 1:95,856,036...95,876,392
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Socs2
suppressor of cytokine signaling 2
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of SOCS2 mRNA
CTD
PMID:17785943
NCBI chr 7:31,890,564...31,932,092
Ensembl chr 7:30,008,578...30,043,548
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Sord
sorbitol dehydrogenase
affects activity
EXP
Hexachlorocyclohexane affects the activity of SORD protein
CTD
PMID:8519523
NCBI chr 3:129,638,282...129,669,727
Ensembl chr 3:109,184,676...109,216,133
G
Spry1
sprouty RTK signaling antagonist 1
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of SPRY1 mRNA
CTD
PMID:17785943
NCBI chr 2:122,484,995...122,490,008
Ensembl chr 2:120,556,706...120,566,189
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Sqle
squalene epoxidase
increases expression
EXP
Hexachlorocyclohexane results in increased expression of SQLE mRNA
CTD
PMID:17785943
NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:90,868,011...90,883,618
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Sqstm1
sequestosome 1
increases expression
ISO
Hexachlorocyclohexane results in increased expression of SQSTM1 mRNA
CTD
PMID:26198647
NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673
G
Srebf1
sterol regulatory element binding transcription factor 1
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of SREBF1 mRNA
CTD
PMID:17785943
NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650
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Srsf2
serine and arginine rich splicing factor 2
increases expression
EXP
Hexachlorocyclohexane results in increased expression of SRSF2 mRNA
CTD
PMID:17785943
NCBI chr10:102,550,962...102,554,200
Ensembl chr10:102,052,314...102,055,338
G
Srxn1
sulfiredoxin 1
increases expression
ISO
Hexachlorocyclohexane results in increased expression of SRXN1 mRNA
CTD
PMID:26198647
NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:140,599,608...140,628,448
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Stam2
signal transducing adaptor molecule 2
increases expression
ISO
Hexachlorocyclohexane results in increased expression of STAM2 mRNA
CTD
PMID:24356939
NCBI chr 3:57,597,557...57,643,915
Ensembl chr 3:37,186,145...37,234,812
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Star
steroidogenic acute regulatory protein
multiple interactions decreases expression increases expression
ISO EXP
Hexachlorocyclohexane inhibits the reaction [Colforsin results in increased expression of STAR mRNA] Hexachlorocyclohexane results in decreased expression of STAR protein Hexachlorocyclohexane results in increased expression of STAR protein Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of STAR protein] Hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR mRNA]; Hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR protein] Hexachlorocyclohexane results in increased expression of STAR mRNA
CTD
PMID:10993823 PMID:15749814 PMID:17080404 PMID:18248869
NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672
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Sult1a1
sulfotransferase family 1A member 1
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of SULT1A1 mRNA
CTD
PMID:9566755
NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:181,272,023...181,275,562
G
Sult2a1
sulfotransferase family 2A member 1
multiple interactions decreases expression
ISO EXP
Hexachlorocyclohexane promotes the reaction [Colforsin results in decreased expression of SULT2A1 mRNA] Hexachlorocyclohexane results in decreased expression of SULT2A1 mRNA
CTD
PMID:9566755 PMID:17080404
NCBI chr 1:84,582,011...84,639,001
Ensembl chr 1:74,911,100...75,508,134
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Tfam
transcription factor A, mitochondrial
increases expression
ISO
Hexachlorocyclohexane results in increased expression of TFAM mRNA
CTD
PMID:23777605
NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292
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Tfb2m
transcription factor B2, mitochondrial
increases expression
ISO
Hexachlorocyclohexane results in increased expression of TFB2M mRNA
CTD
PMID:23777605
NCBI chr13:93,810,859...93,828,678
Ensembl chr13:91,278,898...91,296,657
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of CYP11A1 protein]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased expression of STAR protein]; Hexachlorocyclohexane inhibits the reaction [[FSHB protein co-treated with TGFB1 protein] results in increased phosphorylation of and affects the localization of GJA1 protein]
CTD
PMID:15749814
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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Tjp1
tight junction protein 1
affects localization multiple interactions decreases expression
ISO EXP
Hexachlorocyclohexane affects the localization of TJP1 protein Hexachlorocyclohexane promotes the reaction [GJA1 protein binds to TJP1 protein] Hexachlorocyclohexane results in decreased expression of TJP1 protein
CTD
PMID:11532877 PMID:15194225
NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432
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Tlr4
toll-like receptor 4
increases expression multiple interactions
ISO
Hexachlorocyclohexane results in increased expression of TLR4 protein [Lipopolysaccharides co-treated with Hexachlorocyclohexane] results in increased expression of TLR4 protein
CTD
PMID:28177269
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
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Tm6sf1
transmembrane 6 superfamily member 1
increases expression
ISO
Hexachlorocyclohexane results in increased expression of TM6SF1 mRNA
CTD
PMID:24356939
NCBI chr 1:145,209,052...145,237,725
Ensembl chr 1:135,786,381...135,828,443
G
Tmco6
transmembrane and coiled-coil domains 6
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of TMCO6 mRNA
CTD
PMID:24356939
NCBI chr18:28,623,269...28,629,864
Ensembl chr18:28,349,248...28,355,843
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Tmem177
transmembrane protein 177
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of TMEM177 mRNA
CTD
PMID:24356939
NCBI chr13:31,023,893...31,027,368
Ensembl chr13:31,023,455...31,027,378
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Tmem267
transmembrane protein 267
increases expression
ISO
Hexachlorocyclohexane results in increased expression of TMEM267 mRNA
CTD
PMID:24356939
NCBI chr 2:51,580,210...51,588,937
Ensembl chr 2:51,581,252...51,587,636
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Tnf
tumor necrosis factor
increases expression multiple interactions decreases expression
EXP ISO
Lindane increases expression of Tnf protein in serum [Lipopolysaccharides co-treated with Hexachlorocyclohexane] results in increased expression of TNF protein Hexachlorocyclohexane results in increased expression of TNF protein Hexachlorocyclohexane results in increased expression of TNF mRNA; Hexachlorocyclohexane results in increased expression of TNF protein Hexachlorocyclohexane results in decreased expression of TNF protein [Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased expression of TNF mRNA; [Triiodothyronine co-treated with Hexachlorocyclohexane] results in increased expression of TNF protein; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; Hexachlorocyclohexane inhibits the reaction [Triiodothyronine results in increased expression of TNF protein]
CTD RGD
PMID:15019085 PMID:15025948 PMID:15135310 PMID:15319175 PMID:28177269 PMID:15019085 More...
RGD:14995431
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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Tnxa-ps1
tenascin XA, pseudogene 1
affects expression
EXP
Hexachlorocyclohexane affects the expression of TNXA mRNA
CTD
PMID:17785943
NCBI chr20:4,031,091...4,032,446
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Tor1aip1
torsin 1A interacting protein 1
increases expression
EXP
Hexachlorocyclohexane results in increased expression of TOR1AIP1 mRNA
CTD
PMID:17785943
NCBI chr13:70,746,941...70,776,382
Ensembl chr13:68,196,681...68,225,862
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Tp53
tumor protein p53
multiple interactions
ISO
[Hexachlorocyclohexane co-treated with Estradiol] results in increased expression of TP53 protein
CTD
PMID:18174961
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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Tpm3
tropomyosin 3
affects expression
EXP
Hexachlorocyclohexane affects the expression of TPM3 mRNA
CTD
PMID:17785943
NCBI chr 2:177,812,534...177,842,661
Ensembl chr 2:175,517,226...175,545,013
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Tra2b
transformer 2 beta
affects expression
EXP
Hexachlorocyclohexane affects the expression of TRA2B mRNA
CTD
PMID:17785943
NCBI chr11:92,293,403...92,311,651
Ensembl chr11:78,788,884...78,807,249
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Trib3
tribbles pseudokinase 3
increases expression
ISO
Hexachlorocyclohexane results in increased expression of TRIB3 mRNA
CTD
PMID:24356939
NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:140,809,043...140,814,497
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Tuba4a
tubulin, alpha 4A
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of TUBA4A mRNA
CTD
PMID:17785943
NCBI chr 9:84,158,871...84,174,041
Ensembl chr 9:76,709,614...76,713,918
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Txn2
thioredoxin 2
decreases expression
EXP
Hexachlorocyclohexane results in decreased expression of TXN2 mRNA
CTD
PMID:17785943
NCBI chr 7:111,377,338...111,390,940
Ensembl chr 7:109,496,761...109,510,359
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Tyro3
TYRO3 protein tyrosine kinase
affects expression
EXP
Hexachlorocyclohexane affects the expression of TYRO3 mRNA
CTD
PMID:17785943
NCBI chr 3:127,231,468...127,254,806
Ensembl chr 3:106,777,635...106,797,142
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Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases activity
EXP
Hexachlorocyclohexane results in increased activity of UGT1A1 protein
CTD
PMID:16641539
NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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Ugt1a6
UDP glucuronosyltransferase family 1 member A6
increases expression
EXP
Hexachlorocyclohexane results in increased expression of UGT1A6 mRNA
CTD
PMID:17785943
NCBI chr 9:96,195,018...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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Vegfa
vascular endothelial growth factor A
increases expression
ISO
Hexachlorocyclohexane results in increased expression of VEGFA mRNA
CTD
PMID:24356939
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
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Vip
vasoactive intestinal peptide
decreases response to substance multiple interactions
EXP
Hexachlorocyclohexane results in decreased susceptibility to VIP protein Hexachlorocyclohexane inhibits the reaction [VIP protein results in increased abundance of Cyclic AMP]
CTD
PMID:2467674 PMID:4120787 PMID:20732086
NCBI chr 1:44,470,232...44,478,561
Ensembl chr 1:42,065,120...42,073,216
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Vldlr
very low density lipoprotein receptor
increases expression
ISO
Hexachlorocyclohexane results in increased expression of VLDLR mRNA
CTD
PMID:24356939
NCBI chr 1:234,239,769...234,272,150
Ensembl chr 1:224,814,377...224,845,920
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Wasl
WASP like actin nucleation promoting factor
increases expression
EXP
Hexachlorocyclohexane results in increased expression of WASL mRNA
CTD
PMID:17785943
NCBI chr 4:54,049,081...54,097,653
Ensembl chr 4:53,083,536...53,132,022
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Zfp354a
zinc finger protein 354A
increases expression
EXP
Hexachlorocyclohexane results in increased expression of ZFP354A mRNA
CTD
PMID:17785943
NCBI chr10:35,897,217...35,909,063
Ensembl chr10:35,396,231...35,408,068
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Zfp628
zinc finger protein 628
decreases expression
ISO
Hexachlorocyclohexane results in decreased expression of ZNF628 mRNA
CTD
PMID:24356939
NCBI chr 1:68,913,600...68,921,186
Ensembl chr 1:68,910,401...68,921,243
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions
ISO
gamma-terpinene inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]
CTD
PMID:16904803
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
[4-cymene co-treated with beta-pinene co-treated with gamma-terpinene co-treated with cuminol] results in increased activity of AHR protein; [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol co-treated with carvacrol] results in increased activity of AHR protein; [4-cymene co-treated with gamma-terpinene co-treated with Thymol] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; [4-cymene co-treated with gamma-terpinene co-treated with Thymol] results in increased activity of AHR protein
CTD
PMID:29191726
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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Ar
androgen receptor
multiple interactions
ISO
gamma-terpinene inhibits the reaction [Testosterone results in increased activity of AR protein]
CTD
PMID:31393563
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925
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Ctsd
cathepsin D
increases expression
ISO
gamma-terpinene results in increased expression of CTSD mRNA
CTD
PMID:31393563
NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488
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Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
decreases activity
EXP
gamma-terpinene results in decreased activity of CYP2B1 protein
CTD
PMID:9242356
NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
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Cyp4f6
cytochrome P450, family 4, subfamily f, polypeptide 6
multiple interactions
ISO
gamma-terpinene inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA]
CTD
PMID:31393563
NCBI chr 7:12,680,799...12,708,378
Ensembl chr 7:12,030,301...12,057,782
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Greb1
growth regulating estrogen receptor binding 1
increases expression
ISO
gamma-terpinene results in increased expression of GREB1 mRNA
CTD
PMID:31393563
NCBI chr 6:45,169,289...45,321,973
Ensembl chr 6:39,440,504...39,581,633
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Pgr
progesterone receptor
increases expression multiple interactions
ISO
gamma-terpinene results in increased expression of PGR mRNA Fulvestrant inhibits the reaction [gamma-terpinene results in increased expression of PGR mRNA]
CTD
PMID:31393563
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
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Sec14l2
SEC14-like lipid binding 2
multiple interactions
ISO
gamma-terpinene inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA]
CTD
PMID:31393563
NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788
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Abcb11
ATP binding cassette subfamily B member 11
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB11 mRNA]
CTD
PMID:28549656
NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; [Glycyrrhetinic Acid affects the activity of ABCB1 protein] which affects the susceptibility to Vinblastine; [Glycyrrhetinic Acid affects the activity of ABCB1 protein] which results in increased abundance of Daunorubicin; Glycyrrhetinic Acid inhibits the reaction [ABCB1 protein results in increased uptake of Digoxin]; Glycyrrhetinic Acid inhibits the reaction [Verapamil results in increased activity of ABCB1 protein]
CTD
PMID:16904803 PMID:18204840 PMID:24380838
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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Abcb4
ATP binding cassette subfamily B member 4
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ABCB4 mRNA]
CTD
PMID:28549656
NCBI chr 4:26,106,895...26,164,440
Ensembl chr 4:25,151,953...25,209,202
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Abcc1
ATP binding cassette subfamily C member 1
multiple interactions increases activity
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCC1 mRNA] Glycyrrhetinic Acid results in increased activity of ABCC1 protein [Glycyrrhetinic Acid affects the activity of ABCC1 protein] which affects the susceptibility to Doxorubicin; [Glycyrrhetinic Acid affects the activity of ABCC1 protein] which results in increased abundance of fluorexon
CTD
PMID:18204840 PMID:28549656
NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114
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Abcc2
ATP binding cassette subfamily C member 2
multiple interactions
EXP
Glycyrrhetinic Acid inhibits the reaction [ABCC2 protein results in increased transport of estradiol-17 beta-glucuronide]
CTD
PMID:18436619
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
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Abcc3
ATP binding cassette subfamily C member 3
multiple interactions
ISO
18alpha-glycyrrhetinic acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ABCC3 mRNA]
CTD
PMID:28549656
NCBI chr10:79,793,571...79,839,528
Ensembl chr10:79,296,693...79,342,595
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Abcg2
ATP binding cassette subfamily G member 2
multiple interactions
ISO
Glycyrrhetinic Acid inhibits the reaction [ABCG2 protein results in increased transport of estradiol-17 beta-glucuronide]
CTD
PMID:18436619
NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
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Abcg5
ATP binding cassette subfamily G member 5
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of ABCG5 mRNA]
CTD
PMID:28549656
NCBI chr 6:15,717,936...15,743,376
Ensembl chr 6:9,965,118...9,990,563
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Acat2
acetyl-CoA acetyltransferase 2
multiple interactions
ISO
18alpha-glycyrrhetinic acid affects the reaction [1-Naphthylisothiocyanate affects the expression of ACAT2 mRNA]
CTD
PMID:28549656
NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:47,695,788...47,752,821
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Acta2
actin alpha 2, smooth muscle
multiple interactions
EXP
18alpha-glycyrrhetinic acid inhibits the reaction [Monocrotaline results in increased expression of ACTA2 protein]
CTD
PMID:31325423
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
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Akr1c1
aldo-keto reductase family 1, member C1
decreases activity
ISO
Glycyrrhetinic Acid results in decreased activity of AKR1C1 protein
CTD
PMID:12604236
NCBI chr17:70,720,397...70,747,285
Ensembl chr17:65,810,475...65,837,326
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Akr1c2
aldo-keto reductase family 1, member C2
decreases activity
ISO
Glycyrrhetinic Acid results in decreased activity of AKR1C2 protein
CTD
PMID:12604236
NCBI chr17:70,669,684...70,717,935
Ensembl chr17:65,759,788...65,775,764
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Akr1c3
aldo-keto reductase family 1, member C3
affects activity decreases activity
ISO
18alpha-glycyrrhetinic acid affects the activity of AKR1C3 protein Glycyrrhetinic Acid results in decreased activity of AKR1C3 protein
CTD
PMID:11165023 PMID:12604236
NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873
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Alb
albumin
multiple interactions
ISO
ALB protein binds to and affects the transport of Glycyrrhetinic Acid
CTD
PMID:8831264
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
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Alpl
alkaline phosphatase, biomineralization associated
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [Ethinyl Estradiol results in increased expression of ALPL protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA]
CTD
PMID:21910061 PMID:38244730
NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:149,951,409...150,006,446
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Atf6
activating transcription factor 6
multiple interactions
EXP
18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of ATF6 mRNA]
CTD
PMID:35699857
NCBI chr13:85,460,312...85,639,959
Ensembl chr13:82,930,034...83,107,177
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Atp8b1
ATPase phospholipid transporting 8B1
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of ATP8B1 mRNA]
CTD
PMID:28549656
NCBI chr18:60,286,605...60,427,862
Ensembl chr18:58,018,268...58,157,396
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions decreases expression
EXP ISO
18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of BAX]; 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased expression of BAX protein]; Glycyrrhetinic Acid promotes the reaction [bisphenol A results in increased expression of BAX protein] Glycyrrhetinic Acid results in decreased expression of BAX protein 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of BAX protein]
CTD
PMID:28414158 PMID:31325423 PMID:35699857 PMID:38348715
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
EXP ISO
18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in decreased expression of BCL2]; 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of BCL2 protein]; Glycyrrhetinic Acid inhibits the reaction [bisphenol A results in decreased expression of BCL2 protein] Glycyrrhetinic Acid results in decreased expression of BCL2 protein 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of BCL2 protein]
CTD
PMID:28414158 PMID:31325423 PMID:35699857 PMID:38348715
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bglap
bone gamma-carboxyglutamate protein
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA]
CTD
PMID:21910061
NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:173,838,518...173,839,495
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Bmp2
bone morphogenetic protein 2
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of ALPL protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of BGLAP protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of BGLAP mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA]
CTD
PMID:21910061
NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397
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Casp3
caspase 3
multiple interactions
EXP
18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of CASP3]
CTD
PMID:35699857
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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Cat
catalase
multiple interactions
ISO EXP
Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of CAT mRNA] Glycyrrhetinic Acid inhibits the reaction [bisphenol A results in decreased activity of CAT protein]
CTD
PMID:23341968 PMID:38348715
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of CDKN1B protein]
CTD
PMID:31325423
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
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Col1a1
collagen type I alpha 1 chain
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of COL1A1 mRNA]
CTD
PMID:21910061
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
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Csf2
colony stimulating factor 2
multiple interactions
ISO
Glycyrrhetinic Acid promotes the reaction [Hydrocortisone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]]
CTD
PMID:10460758
NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199
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Cxcr3
C-X-C motif chemokine receptor 3
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [Ethinyl Estradiol results in increased expression of CXCR3 mRNA]
CTD
PMID:38244730
NCBI chr X:70,884,293...70,886,944
Ensembl chr X:66,844,318...66,846,969
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Cycs
cytochrome c, somatic
multiple interactions decreases expression
EXP
Glycyrrhetinic Acid inhibits the reaction [bisphenol A results in increased expression of CYCS protein] Glycyrrhetinic Acid results in decreased expression of CYCS protein
CTD
PMID:38348715
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
EXP
[brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP1A2 protein
CTD
PMID:21800547
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
multiple interactions
EXP
[brucine co-treated with Glycyrrhetinic Acid] results in decreased activity of CYP2E1 protein
CTD
PMID:21800547
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
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Cyp7a1
cytochrome P450 family 7 subfamily A member 1
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in decreased expression of CYP7A1 mRNA]
CTD
PMID:28549656
NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:19,376,974...19,386,688
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Eif2ak3
eukaryotic translation initiation factor 2 alpha kinase 3
multiple interactions
EXP
18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of EIF2AK3 mRNA]
CTD
PMID:35699857
NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911
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Ern1
endoplasmic reticulum to nucleus signaling 1
multiple interactions
ISO EXP
18alpha-glycyrrhetinic acid inhibits the reaction [Cadmium Chloride results in increased expression of ERN1 protein] 18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of ERN1 mRNA]
CTD
PMID:29444456 PMID:35699857
NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029
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Ggt1
gamma-glutamyltransferase 1
multiple interactions
EXP
18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased activity of GGT1 protein]
CTD
PMID:28414158
NCBI chr20:13,074,141...13,103,551
Ensembl chr20:13,074,700...13,108,442
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Got1
glutamic-oxaloacetic transaminase 1
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [Ethinyl Estradiol results in increased expression of GOT1 protein]
CTD
PMID:38244730
NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:242,357,306...242,380,633
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Gpt
glutamic--pyruvic transaminase
multiple interactions
EXP ISO
18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased activity of GPT protein] 18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased activity of GPT protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [Ethinyl Estradiol results in increased expression of GPT protein]; Glycyrrhetinic Acid inhibits the reaction [diosbulbin B results in increased activity of GPT protein]
CTD
PMID:28414158 PMID:28549656 PMID:36807597 PMID:38244730
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
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Gpx2
glutathione peroxidase 2
multiple interactions
ISO
Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of GPX2 mRNA]
CTD
PMID:23341968
NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:95,493,589...95,496,877
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Hmox1
heme oxygenase 1
multiple interactions
EXP
18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of HMOX1 mRNA]
CTD
PMID:28414158
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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Hras
HRas proto-oncogene, GTPase
decreases expression
ISO
Glycyrrhetinic Acid results in decreased expression of HRAS protein
CTD
PMID:19958823
NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615
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Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
decreases activity
ISO
18alpha-glycyrrhetinic acid results in decreased activity of HSD11B1 protein
CTD
PMID:24135201
NCBI chr13:107,277,526...107,327,462
Ensembl chr13:104,728,539...104,788,687
G
Hsd11b2
hydroxysteroid 11-beta dehydrogenase 2
decreases activity multiple interactions
ISO
18alpha-glycyrrhetinic acid results in decreased activity of HSD11B2 protein Glycyrrhetinic Acid inhibits the reaction [tributyltin results in increased activity of HSD11B2 protein]; Glycyrrhetinic Acid inhibits the reaction [triphenyltin chloride results in increased activity of HSD11B2 protein]
CTD
PMID:24135201 PMID:31927052
NCBI chr19:50,307,569...50,312,812
Ensembl chr19:33,397,656...33,402,899
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Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
multiple interactions
ISO
[Glycyrrhetinic Acid co-treated with NADP] binds to HSD3B1 protein
CTD
PMID:25526675
NCBI chr 2:188,858,574...188,864,694
Ensembl chr 2:186,169,863...186,175,999
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Hspa5
heat shock protein family A (Hsp70) member 5
multiple interactions
EXP
18alpha-glycyrrhetinic acid inhibits the reaction [bisphenol A results in increased expression of HSPA5 mRNA]
CTD
PMID:35699857
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
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Il1b
interleukin 1 beta
multiple interactions
ISO EXP
Glycyrrhetinic Acid promotes the reaction [Hydrocortisone inhibits the reaction [IL1B protein results in increased secretion of CSF2 protein]] 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased expression of IL1B protein] Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL1B mRNA]
CTD
PMID:10460758 PMID:23373965 PMID:28414158
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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Il6
interleukin 6
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]
CTD
PMID:21644799 PMID:23373965 PMID:24849676
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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Irak1
interleukin-1 receptor-associated kinase 1
multiple interactions
ISO
Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]]
CTD
PMID:28213090
NCBI chr X:156,919,927...156,929,825
Ensembl chr X:151,768,777...151,778,521
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Irak3
interleukin-1 receptor-associated kinase 3
multiple interactions increases expression
ISO
[Glycyrrhetinic Acid co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IRAK3 mRNA; IRAK3 protein promotes the reaction [Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]] Glycyrrhetinic Acid results in increased expression of IRAK3 protein
CTD
PMID:28213090
NCBI chr 7:57,538,522...57,600,166
Ensembl chr 7:55,653,962...55,713,121
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Ly96
lymphocyte antigen 96
multiple interactions
ISO
Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [TLR4 protein binds to LY96 protein]]
CTD
PMID:28213090
NCBI chr 5:7,365,536...7,397,864
Ensembl chr 5:2,582,254...2,612,386
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Map3k5
mitogen-activated protein kinase kinase kinase 5
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [Cadmium Chloride results in increased expression of MAP3K5 protein]
CTD
PMID:29444456
NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:14,685,492...14,904,800
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Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]
CTD
PMID:23373965
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]
CTD
PMID:23373965
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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Mmp9
matrix metallopeptidase 9
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]
CTD
PMID:24613819
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
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Mpo
myeloperoxidase
multiple interactions
ISO
Glycyrrhetinic Acid inhibits the reaction [diosbulbin B results in increased activity of MPO protein]
CTD
PMID:36807597
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
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Mttp
microsomal triglyceride transfer protein
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of MTTP mRNA]
CTD
PMID:28549656
NCBI chr 2:229,286,501...229,327,650
Ensembl chr 2:226,613,090...226,654,239
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Nfe2l2
NFE2 like bZIP transcription factor 2
increases expression multiple interactions
ISO EXP
Glycyrrhetinic Acid results in increased expression of NFE2L2 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of NFE2L2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of NFE2L2 protein] [Glycyrrhetinic Acid results in increased expression of NFE2L2] which results in decreased susceptibility to Carbon Tetrachloride; Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride affects the localization of NFE2L2 protein]
CTD
PMID:23341968 PMID:28414158
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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Nfkb1
nuclear factor kappa B subunit 1
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in decreased expression of NFKB1 protein]
CTD
PMID:24613819
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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Nfkbia
NFKB inhibitor alpha
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein] Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased phosphorylation of NFKBIA protein]; Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and affects the localization of NFKBIA protein]
CTD
PMID:23373965 PMID:24613819 PMID:28213090
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]
CTD
PMID:21644799 PMID:23373965
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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Npc1l1
NPC1 like intracellular cholesterol transporter 1
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of NPC1L1 mRNA]
CTD
PMID:28549656
NCBI chr14:85,285,387...85,305,050
Ensembl chr14:81,071,451...81,091,113
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Nr1h4
nuclear receptor subfamily 1, group H, member 4
multiple interactions
EXP
glycyrrhetinic acid inhibits the reaction [1-naphthyl isothiocyanate decreases expression of Nr1h4 mRNA in liver]
RGD
PMID:30061734
RGD:15092071
NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:23,846,122...23,942,047
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Pdgfb
platelet derived growth factor subunit B
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of BAX protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in decreased expression of CDKN1B protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of BCL2 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of RHOA mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of RHOA protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK2 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased phosphorylation of PPP1R12A protein]
CTD
PMID:31325423
NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984
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Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
decreases activity
ISO
18alpha-glycyrrhetinic acid results in decreased activity of PIK3CD protein
CTD
PMID:21644799
NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:160,094,952...160,120,930
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Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
decreases activity
ISO
18alpha-glycyrrhetinic acid results in decreased activity of PIK3CG protein
CTD
PMID:21644799
NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043
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Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
EXP
18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of PPARG mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in decreased expression of PPARG protein]
CTD
PMID:28414158
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
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Ppp1r12a
protein phosphatase 1, regulatory subunit 12A
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased phosphorylation of PPP1R12A protein]
CTD
PMID:31325423
NCBI chr 7:45,368,922...45,480,158
Ensembl chr 7:43,482,803...43,593,425
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Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]
CTD
PMID:21644799
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in decreased expression of RELA protein] Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]
CTD
PMID:23373965 PMID:24613819
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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Ren
renin
decreases activity
ISO
Glycyrrhetinic Acid results in decreased activity of REN protein
CTD
PMID:20460744
NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489
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Rhoa
ras homolog family member A
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of RHOA mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of RHOA protein]
CTD
PMID:31325423
NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746
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Rock1
Rho-associated coiled-coil containing protein kinase 1
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK1 protein]
CTD
PMID:31325423
NCBI chr18:1,387,360...1,509,218
Ensembl chr18:1,115,905...1,235,571
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Rock2
Rho-associated coiled-coil containing protein kinase 2
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK2 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [[PDGFB protein co-treated with PDGFB protein] results in increased expression of ROCK2 protein]
CTD
PMID:31325423
NCBI chr 6:45,407,823...45,502,773
Ensembl chr 6:39,679,082...39,774,031
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Rorc
RAR-related orphan receptor C
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [Ethinyl Estradiol results in increased expression of RORC mRNA]
CTD
PMID:38244730
NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:182,009,286...182,034,907
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Runx2
RUNX family transcription factor 2
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased activity of RUNX2 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of ALPL mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [RUNX2 protein results in increased expression of BGLAP mRNA]
CTD
PMID:21910061
NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167
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Slc51b
SLC51 subunit beta
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLC51B mRNA]
CTD
PMID:28549656
NCBI chr 8:74,827,047...74,835,109
Ensembl chr 8:65,931,890...65,940,145
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Slco1a4
solute carrier organic anion transporter family, member 1a4
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of SLCO1A4 mRNA]
CTD
PMID:28549656
NCBI chr 4:176,441,104...176,495,846
Ensembl chr 4:174,710,004...175,254,573
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Sod3
superoxide dismutase 3
multiple interactions
ISO
Glycyrrhetinic Acid inhibits the reaction [Carbon Tetrachloride results in decreased expression of SOD3 mRNA]
CTD
PMID:23341968
NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990
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Sp7
Sp7 transcription factor
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA]
CTD
PMID:21910061
NCBI chr 7:135,363,193...135,373,376
Ensembl chr 7:133,484,609...133,494,847
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Tlr4
toll-like receptor 4
multiple interactions
ISO
Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of [TLR4 protein binds to LY96 protein]]
CTD
PMID:28213090
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
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Tnf
tumor necrosis factor
multiple interactions
ISO EXP
18alpha-glycyrrhetinic acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased expression of and results in increased secretion of TNF protein]; Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] results in increased expression of TNF mRNA]; Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; IRAK3 protein promotes the reaction [Glycyrrhetinic Acid inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]] 18alpha-glycyrrhetinic acid inhibits the reaction [Methotrexate results in increased expression of TNF protein] 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in decreased expression of NFKB1 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in decreased expression of RELA protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of VEGFA protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]
CTD
PMID:21644799 PMID:24613819 PMID:28213090 PMID:28414158
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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Tp53
tumor protein p53
decreases expression
EXP
Glycyrrhetinic Acid results in decreased expression of TP53 protein
CTD
PMID:38348715
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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Traf6
TNF receptor associated factor 6
multiple interactions
ISO
Glycyrrhetinic Acid inhibits the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with Galactosamine] promotes the reaction [TRAF6 protein binds to IRAK1 protein]]
CTD
PMID:28213090
NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507
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Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of VEGFA protein]; 18alpha-glycyrrhetinic acid inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]
CTD
PMID:24613819
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
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Xbp1
X-box binding protein 1
multiple interactions
ISO
18alpha-glycyrrhetinic acid inhibits the reaction [Cadmium Chloride results in increased expression of XBP1 protein alternative form]
CTD
PMID:29444456
NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693
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Ache
acetylcholinesterase
multiple interactions decreases activity
ISO
Trimedoxime inhibits the reaction [heptenophos results in decreased activity of ACHE protein] asoxime chloride inhibits the reaction [heptenophos results in decreased activity of ACHE protein]; HLo 7 inhibits the reaction [heptenophos results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [heptenophos results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [heptenophos results in decreased activity of ACHE protein]
CTD
PMID:8783813 PMID:15679473
NCBI chr12:25,042,882...25,050,608
Ensembl chr12:19,407,360...19,413,651
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Abcb1a
ATP binding cassette subfamily B member 1A
increases expression multiple interactions
ISO
hyperforin results in increased expression of ABCB1; hyperforin results in increased expression of ABCB1 mRNA hyperforin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]
CTD
PMID:15266218 PMID:16005588 PMID:24259679
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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Alas1
5'-aminolevulinate synthase 1
increases expression
ISO
hyperforin results in increased expression of ALAS1 mRNA
CTD
PMID:24259679
NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:106,876,514...106,889,917
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Bak1
BCL2-antagonist/killer 1
increases expression
ISO
hyperforin results in increased expression of BAK1 protein
CTD
PMID:32485087
NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264
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Bax
BCL2 associated X, apoptosis regulator
decreases expression increases expression multiple interactions
EXP ISO
hyperforin results in decreased expression of BAX mRNA hyperforin results in increased expression of BAX protein hyperforin inhibits the reaction [aluminum maltolate results in increased expression of BAX mRNA]
CTD
PMID:30481499 PMID:32485087
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions increases expression
EXP ISO
hyperforin inhibits the reaction [aluminum maltolate results in decreased expression of BCL2 mRNA] hyperforin results in increased expression of BCL2 mRNA
CTD
PMID:30481499
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
multiple interactions increases cleavage decreases expression
ISO EXP
hyperforin inhibits the reaction [aluminum maltolate results in increased activity of CASP3 protein]; hyperforin inhibits the reaction [aluminum maltolate results in increased expression of CASP3 mRNA] hyperforin results in increased cleavage of CASP3 protein hyperforin inhibits the reaction [aluminum maltolate results in increased activity of CASP3 protein]; hyperforin inhibits the reaction [aluminum maltolate results in increased expression of CASP3 mRNA]; hyperforin inhibits the reaction [Propofol results in increased cleavage of CASP3 protein] hyperforin results in decreased expression of CASP3 mRNA
CTD
PMID:30481499 PMID:32485087 PMID:36640868
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
increases cleavage
ISO
hyperforin results in increased cleavage of CASP8 protein
CTD
PMID:32485087
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
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Ccnd1
cyclin D1
decreases expression
ISO
hyperforin results in decreased expression of CCND1 protein
CTD
PMID:32485087
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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Cflar
CASP8 and FADD-like apoptosis regulator
decreases expression
ISO
hyperforin results in decreased expression of CFLAR protein
CTD
PMID:32485087
NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034
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Cycs
cytochrome c, somatic
multiple interactions decreases expression
EXP ISO
hyperforin inhibits the reaction [aluminum maltolate results in increased expression of CYCS protein] hyperforin results in decreased expression of CYCS protein
CTD
PMID:30481499
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions decreases activity
ISO
hyperforin inhibits the reaction [CYP1A1 protein affects the metabolism of benzo(a)pyrene 7,8-dihydrodiol] hyperforin results in decreased activity of CYP1A1 protein
CTD
PMID:14633740
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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Cyp24a1
cytochrome P450, family 24, subfamily a, polypeptide 1
increases expression
ISO
hyperforin results in increased expression of CYP24A1 mRNA
CTD
PMID:15630458
NCBI chr 3:179,694,647...179,709,083
Ensembl chr 3:159,275,947...159,290,383
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression
ISO
hyperforin results in increased expression of CYP2B6 mRNA
CTD
PMID:24259679
NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
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Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions increases expression decreases activity
ISO
hyperforin results in increased expression of and results in increased activity of CYP3A4 protein hyperforin results in increased expression of CYP3A4; hyperforin results in increased expression of CYP3A4 mRNA hyperforin results in decreased activity of CYP3A4 protein
CTD
PMID:15100173 PMID:15266218 PMID:16005588 PMID:16442130 PMID:17954527 PMID:24259679 More...
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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Cyp3a9
cytochrome P450, family 3, subfamily a, polypeptide 9
increases expression
ISO
hyperforin results in increased expression of CYP3A5 mRNA
CTD
PMID:24259679
NCBI chr12:21,919,955...21,960,160
Ensembl chr12:16,806,207...16,846,422
G
Cyp7a1
cytochrome P450 family 7 subfamily A member 1
decreases expression
ISO
hyperforin results in decreased expression of CYP7A1 mRNA
CTD
PMID:24259679
NCBI chr 5:24,174,505...24,184,202
Ensembl chr 5:19,376,974...19,386,688
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Egfr
epidermal growth factor receptor
decreases phosphorylation
ISO
hyperforin results in decreased phosphorylation of EGFR protein
CTD
PMID:32485087
NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382
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Fas
Fas cell surface death receptor
increases expression
ISO
hyperforin results in increased expression of FAS protein
CTD
PMID:32485087
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
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Faslg
Fas ligand
increases expression
ISO
hyperforin results in increased expression of FASLG protein
CTD
PMID:32485087
NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
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Icam1
intercellular adhesion molecule 1
increases expression
ISO
hyperforin results in increased expression of ICAM1 mRNA
CTD
PMID:15622447
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
hyperforin promotes the reaction [JUN protein binds to CXCL8 promoter]
CTD
PMID:15622447
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
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Mapk1
mitogen activated protein kinase 1
increases phosphorylation decreases phosphorylation
ISO
hyperforin results in increased phosphorylation of MAPK1 protein hyperforin results in decreased phosphorylation of MAPK1 protein
CTD
PMID:15622447 PMID:32485087
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
increases phosphorylation decreases phosphorylation
ISO
hyperforin results in increased phosphorylation of MAPK3 protein hyperforin results in decreased phosphorylation of MAPK3 protein
CTD
PMID:15622447 PMID:32485087
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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Mcl1
MCL1 apoptosis regulator, BCL2 family member
decreases expression
ISO
hyperforin results in decreased expression of MCL1 protein
CTD
PMID:32485087
NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303
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Nr1i2
nuclear receptor subfamily 1, group I, member 2
multiple interactions increases activity increases response to substance affects binding
ISO
[NR1I2 protein co-treated with hyperforin] results in decreased expression of SLC22A1 mRNA; [NR1I2 protein results in increased susceptibility to hyperforin] which results in decreased expression of SLC22A1 mRNA; hyperforin binds to and results in increased activity of NR1I2 protein; hyperforin promotes the reaction [NR1I2 protein results in decreased expression of SLC22A1 mRNA]; NR1I2 protein affects the reaction [hyperforin results in increased expression of CYP2C9 mRNA]; NR1I2 protein promotes the reaction [hyperforin results in increased abundance of Lipids] hyperforin results in increased activity of NR1I2 protein hyperforin binds to NR1I2 protein
CTD
PMID:14600250 PMID:15630458 PMID:15856409 PMID:20079722 PMID:26187274 PMID:26920453 PMID:27071811 More...
NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
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Por
cytochrome p450 oxidoreductase
increases expression
ISO
hyperforin results in increased expression of POR mRNA
CTD
PMID:24259679
NCBI chr12:26,587,674...26,655,612
Ensembl chr12:20,951,058...20,999,245
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Slc22a1
solute carrier family 22 member 1
decreases expression multiple interactions
ISO
hyperforin results in decreased expression of SLC22A1 protein [NR1I2 protein co-treated with hyperforin] results in decreased expression of SLC22A1 mRNA; [NR1I2 protein results in increased susceptibility to hyperforin] which results in decreased expression of SLC22A1 mRNA; hyperforin promotes the reaction [NR1I2 protein results in decreased expression of SLC22A1 mRNA]
CTD
PMID:26920453
NCBI chr 1:50,624,339...50,651,437
Ensembl chr 1:48,076,666...48,103,678
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Trpc6
transient receptor potential cation channel, subfamily C, member 6
multiple interactions
EXP
hyperforin inhibits the reaction [Propofol results in decreased expression of TRPC6 protein]
CTD
PMID:36640868
NCBI chr 8:14,044,216...14,148,808
Ensembl chr 8:5,758,935...5,828,092
G
Ugt1a1
UDP glucuronosyltransferase family 1 member A1
increases expression
ISO
hyperforin results in increased expression of UGT1A1 mRNA
CTD
PMID:24259679
NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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Xiap
X-linked inhibitor of apoptosis
decreases expression
ISO
hyperforin results in decreased expression of XIAP protein
CTD
PMID:32485087
NCBI chr X:125,756,107...125,803,979
Ensembl chr X:120,897,907...120,934,700
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Ercc6
ERCC excision repair 6, chromatin remodeling factor
increases response to substance
ISO
ERCC6 mutant form results in increased susceptibility to irofulven
CTD
PMID:28076683
NCBI chr16:7,771,311...7,841,895
Ensembl chr16:7,765,013...7,835,587
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Gsr
glutathione-disulfide reductase
decreases activity
ISO
irofulven results in decreased activity of GSR protein
CTD
PMID:19668867
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
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Abca1
ATP binding cassette subfamily A member 1
increases expression
EXP
Ketamine results in increased expression of ABCA1 mRNA
CTD
PMID:20080153
NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170
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Abcb1a
ATP binding cassette subfamily B member 1A
multiple interactions
ISO
ABCB1A protein affects the susceptibility to [Pentobarbital co-treated with Ketamine]
CTD
PMID:17959987
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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Abcg1
ATP binding cassette subfamily G member 1
increases expression
EXP
Ketamine results in increased expression of ABCG1 mRNA
CTD
PMID:20080153
NCBI chr20:9,128,056...9,184,312
Ensembl chr20:9,126,687...9,182,948
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Abhd16a
abhydrolase domain containing 16A, phospholipase
increases expression
EXP
Ketamine results in increased expression of ABHD16A mRNA
CTD
PMID:20080153
NCBI chr20:3,723,756...3,738,617
Ensembl chr20:3,719,091...3,733,927
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Abhd5
abhydrolase domain containing 5, lysophosphatidic acid acyltransferase
decreases expression
EXP
Ketamine results in decreased expression of ABHD5 mRNA
CTD
PMID:20080153
NCBI chr 8:130,877,834...130,903,947
Ensembl chr 8:122,000,389...122,026,447
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Acat2
acetyl-CoA acetyltransferase 2
decreases expression
EXP
Ketamine results in decreased expression of ACAT2 mRNA
CTD
PMID:20080153
NCBI chr 1:50,100,840...50,118,886
Ensembl chr 1:47,695,788...47,752,821
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Acbd3
acyl-CoA binding domain containing 3
decreases expression
EXP
Ketamine results in decreased expression of ACBD3 mRNA
CTD
PMID:20080153
NCBI chr13:94,987,643...95,016,356
Ensembl chr13:92,455,655...92,483,380
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Acbd5
acyl-CoA binding domain containing 5
decreases expression
EXP
Ketamine results in decreased expression of ACBD5 mRNA
CTD
PMID:20080153
NCBI chr17:90,114,250...90,156,286
Ensembl chr17:85,206,303...85,248,215
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Ace
angiotensin I converting enzyme
increases expression
EXP
Ketamine results in increased expression of ACE mRNA
CTD
PMID:20080153
NCBI chr10:91,410,129...91,430,246
Ensembl chr10:90,910,316...90,931,131
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Acp6
acid phosphatase 6, lysophosphatidic
decreases expression
EXP
Ketamine results in decreased expression of ACP6 mRNA
CTD
PMID:20080153
NCBI chr 2:187,400,786...187,421,877
Ensembl chr 2:184,711,619...184,733,017
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Acr
acrosin
increases expression
EXP
Ketamine results in increased expression of ACR mRNA
CTD
PMID:20080153
NCBI chr 7:122,517,910...122,524,110
Ensembl chr 7:120,638,321...120,644,474
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Acsbg1
acyl-CoA synthetase bubblegum family member 1
increases expression
EXP
Ketamine results in increased expression of ACSBG1 mRNA
CTD
PMID:20080153
NCBI chr 8:63,887,433...63,943,486
Ensembl chr 8:54,991,296...55,047,391
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Acta2
actin alpha 2, smooth muscle
increases expression multiple interactions
ISO
Ketamine results in increased expression of ACTA2 mRNA; Ketamine results in increased expression of ACTA2 protein 2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [Ketamine results in increased expression of ACTA2 protein]
CTD
PMID:28331066
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
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Actg2
actin gamma 2, smooth muscle
decreases expression
EXP
Ketamine results in decreased expression of ACTG2 mRNA
CTD
PMID:20080153
NCBI chr 4:117,579,513...117,604,379
Ensembl chr 4:116,021,832...116,046,465
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Acvr1c
activin A receptor type 1C
decreases expression
EXP
Ketamine results in decreased expression of ACVR1C mRNA
CTD
PMID:20080153
NCBI chr 3:63,224,322...63,301,252
Ensembl chr 3:42,822,610...42,892,327
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Adam24
ADAM metallopeptidase domain 24
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of ADAM24 mRNA
CTD
PMID:16635253
NCBI chr16:58,281,748...58,287,735
Ensembl chr16:51,578,277...51,584,312
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Adap2
ArfGAP with dual PH domains 2
increases expression
EXP
Ketamine results in increased expression of ADAP2 mRNA
CTD
PMID:20080153
NCBI chr10:65,635,891...65,665,019
Ensembl chr10:65,138,020...65,165,604
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Adck2
aarF domain containing kinase 2
decreases expression
EXP
Ketamine results in decreased expression of ADCK2 mRNA
CTD
PMID:20080153
NCBI chr 4:69,315,633...69,328,535
Ensembl chr 4:68,348,864...68,374,608
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Adcy8
adenylate cyclase 8
decreases expression
EXP
Ketamine results in decreased expression of ADCY8 mRNA
CTD
PMID:20080153
NCBI chr 7:98,306,434...98,555,687
Ensembl chr 7:96,417,324...96,665,911
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Adcy9
adenylate cyclase 9
increases expression
EXP
Ketamine results in increased expression of ADCY9 mRNA
CTD
PMID:20080153
NCBI chr10:11,645,373...11,768,462
Ensembl chr10:11,139,446...11,262,066
G
Adcyap1
adenylate cyclase activating polypeptide 1
decreases expression multiple interactions
EXP
Ketamine results in decreased expression of ADCYAP1 mRNA [ampullosporin co-treated with Ketamine] results in decreased expression of ADCYAP1 mRNA
CTD
PMID:16635253 PMID:20080153
NCBI chr 9:120,550,236...120,569,096
Ensembl chr 9:113,103,718...113,109,773
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Add2
adducin 2
decreases expression
EXP
Ketamine results in decreased expression of ADD2 mRNA
CTD
PMID:20080153
NCBI chr 4:120,001,977...120,101,090
Ensembl chr 4:118,497,416...118,538,505
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Adgrb2
adhesion G protein-coupled receptor B2
increases expression
EXP
Ketamine results in increased expression of ADGRB2 mRNA
CTD
PMID:20080153
NCBI chr 5:147,581,573...147,646,726
Ensembl chr 5:142,331,329...142,362,540
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Afp
alpha-fetoprotein
increases expression
EXP
Ketamine results in increased expression of AFP mRNA
CTD
PMID:20080153
NCBI chr14:17,857,584...17,875,645
Ensembl chr14:17,573,412...17,591,480
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Agt
angiotensinogen
decreases expression multiple interactions increases expression
ISO EXP
Ketamine results in decreased expression of AGT protein [ampullosporin co-treated with Ketamine] results in increased expression of AGT mRNA Ketamine results in increased expression of AGT mRNA
CTD
PMID:6349867 PMID:16635253 PMID:20080153
NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977
G
Agtrap
angiotensin II receptor-associated protein
increases expression
EXP
Ketamine results in increased expression of AGTRAP mRNA
CTD
PMID:20080153
NCBI chr 5:163,790,565...163,802,174
Ensembl chr 5:158,508,749...158,519,036
G
Ahr
aryl hydrocarbon receptor
decreases expression
EXP
Ketamine results in decreased expression of AHR mRNA
CTD
PMID:20080153
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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Aif1
allograft inflammatory factor 1
decreases expression multiple interactions
EXP ISO
Ketamine results in decreased expression of AIF1 mRNA Ketamine results in decreased expression of AIF1 protein Cannabidiol inhibits the reaction [Ketamine results in decreased expression of AIF1 mRNA]
CTD
PMID:31823199 PMID:36172893
NCBI chr20:3,651,435...3,657,341
Ensembl chr20:3,646,777...3,652,668
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Akap9
A-kinase anchoring protein 9
decreases expression
EXP
Ketamine results in decreased expression of AKAP9 mRNA
CTD
PMID:20080153
NCBI chr 4:31,011,475...31,147,338
Ensembl chr 4:30,056,738...30,192,606
G
Alas1
5'-aminolevulinate synthase 1
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of ALAS1 mRNA
CTD
PMID:16635253
NCBI chr 8:115,755,238...115,768,642
Ensembl chr 8:106,876,514...106,889,917
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Alb
albumin
increases expression
EXP
Ketamine results in increased expression of ALB mRNA
CTD
PMID:20080153
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
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Aldh18a1
aldehyde dehydrogenase 18 family, member A1
decreases expression
EXP
Ketamine results in decreased expression of ALDH18A1 mRNA
CTD
PMID:20080153
NCBI chr 1:249,325,082...249,357,383
Ensembl chr 1:239,375,669...239,407,890
G
Aldoc
aldolase, fructose-bisphosphate C
increases expression
EXP
Ketamine results in increased expression of ALDOC mRNA
CTD
PMID:20080153
NCBI chr10:63,715,544...63,719,133
Ensembl chr10:63,217,451...63,221,066
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Alms1
ALMS1, centrosome and basal body associated protein
decreases expression
EXP
Ketamine results in decreased expression of ALMS1 mRNA
CTD
PMID:20080153
NCBI chr 4:119,683,085...119,783,471
Ensembl chr 4:118,125,607...118,226,005
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Alpl
alkaline phosphatase, biomineralization associated
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of ALPL mRNA
CTD
PMID:16635253
NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:149,951,409...150,006,446
G
Amhr2
anti-Mullerian hormone receptor type 2
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of AMHR2 mRNA
CTD
PMID:16635253
NCBI chr 7:135,454,517...135,470,183
Ensembl chr 7:133,579,393...133,588,258
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Amigo2
adhesion molecule with Ig like domain 2
decreases expression
EXP
Ketamine results in decreased expression of AMIGO2 mRNA
CTD
PMID:20080153
NCBI chr 7:130,270,639...130,273,735
Ensembl chr 7:128,390,412...128,394,695
G
Anapc1
anaphase promoting complex subunit 1
increases expression
EXP
Ketamine results in increased expression of ANAPC1 mRNA
CTD
PMID:20080153
NCBI chr 3:136,303,350...136,383,464
Ensembl chr 3:115,850,185...115,930,273
G
Angptl4
angiopoietin-like 4
increases expression
EXP
Ketamine results in increased expression of ANGPTL4 mRNA
CTD
PMID:20080153
NCBI chr 7:15,252,450...15,259,971
Ensembl chr 7:14,550,311...14,556,519
G
Ankrd42
ankyrin repeat domain 42
decreases expression
EXP
Ketamine results in decreased expression of ANKRD42 mRNA
CTD
PMID:20080153
NCBI chr 1:146,648,080...146,691,086
Ensembl chr 1:146,648,080...146,691,108
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Anxa11
annexin A11
increases expression
EXP
Ketamine results in increased expression of ANXA11 mRNA
CTD
PMID:20080153
NCBI chr16:1,419,627...1,464,590
Ensembl chr16:1,410,756...1,457,797
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Anxa3
annexin A3
decreases expression
EXP
Ketamine results in decreased expression of ANXA3 mRNA
CTD
PMID:20080153
NCBI chr14:13,031,675...13,085,678
Ensembl chr14:12,719,795...12,781,617
G
Anxa4
annexin A4
increases expression
EXP
Ketamine results in increased expression of ANXA4 mRNA
CTD
PMID:20080153
NCBI chr 4:120,741,750...120,798,534
Ensembl chr 4:119,184,374...119,241,161
G
Anxa5
annexin A5
decreases expression multiple interactions
EXP
Ketamine results in decreased expression of ANXA5 mRNA [ampullosporin co-treated with Ketamine] results in decreased expression of ANXA5 mRNA
CTD
PMID:16635253 PMID:20080153
NCBI chr 2:121,242,133...121,272,935
Ensembl chr 2:119,314,007...119,353,369
G
Ap2m1
adaptor related protein complex 2 subunit mu 1
multiple interactions
ISO
Ketamine inhibits the reaction [NTRK2 protein binds to AP2M1 protein]
CTD
PMID:31631060
NCBI chr11:93,859,690...93,868,600
Ensembl chr11:80,328,041...80,364,140
G
Ap3m1
adaptor related protein complex 3 subunit mu 1
decreases expression
EXP
Ketamine results in decreased expression of AP3M1 mRNA
CTD
PMID:20080153
NCBI chr15:3,285,591...3,314,139
Ensembl chr15:3,246,926...3,264,844
G
Ap5m1
adaptor related protein complex 5 subunit mu 1
decreases expression
EXP
Ketamine results in decreased expression of AP5M1 mRNA
CTD
PMID:20080153
NCBI chr15:22,355,478...22,385,222
Ensembl chr15:22,355,500...22,377,750
G
Apex2
apurinic/apyrimidinic endodeoxyribonuclease 2
decreases expression
EXP
Ketamine results in decreased expression of APEX2 mRNA
CTD
PMID:20080153
NCBI chr X:22,914,943...22,937,713
Ensembl chr X:19,487,419...19,508,439
G
Aplf
aprataxin and PNKP like factor
decreases expression
EXP
Ketamine results in decreased expression of APLF mRNA
CTD
PMID:20080153
NCBI chr 4:121,627,800...121,679,980
Ensembl chr 4:120,070,471...120,122,633
G
Apmap
adipocyte plasma membrane associated protein
increases expression
EXP
Ketamine results in increased expression of APMAP mRNA
CTD
PMID:20080153
NCBI chr 3:159,869,451...159,897,727
Ensembl chr 3:139,409,022...139,437,341
G
Apoe
apolipoprotein E
decreases response to substance increases expression
ISO EXP
APOE results in decreased susceptibility to Ketamine Ketamine results in increased expression of APOE mRNA
CTD
PMID:9778666 PMID:20080153
NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932
G
App
amyloid beta precursor protein
multiple interactions increases expression
ISO
[Ketamine results in increased cleavage of APP protein] which results in increased abundance of amyloid beta-protein (1-40); [Ketamine results in increased cleavage of APP protein] which results in increased abundance of amyloid beta-protein (1-42); Ketamine results in decreased expression of and results in increased cleavage of APP protein; Monensin inhibits the reaction [[Ketamine results in increased cleavage of APP protein] which results in increased abundance of amyloid beta-protein (1-40)]; Monensin inhibits the reaction [[Ketamine results in increased cleavage of APP protein] which results in increased abundance of amyloid beta-protein (1-42)] Ketamine results in decreased expression of and results in increased cleavage of APP protein; Monensin inhibits the reaction [Ketamine results in decreased expression of and results in increased cleavage of APP protein] Ketamine results in increased expression of APP mRNA
CTD
PMID:35378374
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
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Appbp2
amyloid beta precursor protein binding protein 2
decreases expression
EXP
Ketamine results in decreased expression of APPBP2 mRNA
CTD
PMID:20080153
NCBI chr10:70,555,212...70,597,267
Ensembl chr10:70,057,774...70,099,835
G
Arf3
ARF GTPase 3
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of ARF3 mRNA
CTD
PMID:16635253
NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002
G
Arfgef1
ARF guanine nucleotide exchange factor 1
decreases expression
EXP
Ketamine results in decreased expression of ARFGEF1 mRNA
CTD
PMID:20080153
NCBI chr 5:13,764,507...13,859,237
Ensembl chr 5:8,981,540...9,076,326
G
Arhgap5
Rho GTPase activating protein 5
decreases expression
EXP
Ketamine results in decreased expression of ARHGAP5 mRNA
CTD
PMID:20080153
NCBI chr 6:75,711,199...75,774,636
Ensembl chr 6:69,976,214...70,037,660
G
Arih1
ariadne RBR E3 ubiquitin protein ligase 1
decreases expression
EXP
Ketamine results in decreased expression of ARIH1 mRNA
CTD
PMID:20080153
NCBI chr 8:68,673,199...68,775,648
Ensembl chr 8:59,777,379...59,880,245
G
Arl6
ARF like GTPase 6
decreases expression
EXP
Ketamine results in decreased expression of ARL6 mRNA
CTD
PMID:20080153
NCBI chr11:40,711,878...40,738,254
Ensembl chr11:40,712,022...40,737,937
G
Arl6ip6
ARF like GTPase 6 interacting protein 6
decreases expression
EXP
Ketamine results in decreased expression of ARL6IP6 mRNA
CTD
PMID:20080153
NCBI chr 3:37,689,994...37,720,358
Ensembl chr 3:37,690,382...37,718,018
G
Armc10
armadillo repeat containing 10
decreases expression
EXP
Ketamine results in decreased expression of ARMC10 mRNA
CTD
PMID:20080153
NCBI chr 4:13,399,004...13,414,594
Ensembl chr 4:13,395,207...13,414,548
G
Art3
ADP-ribosyltransferase 3
increases expression
EXP
Ketamine results in increased expression of ART3 mRNA
CTD
PMID:20080153
NCBI chr14:15,921,540...16,003,764
Ensembl chr14:15,637,237...15,665,407
G
Ascl1
achaete-scute family bHLH transcription factor 1
decreases expression
EXP
Ketamine results in decreased expression of ASCL1 mRNA
CTD
PMID:20080153
NCBI chr 7:23,790,642...23,793,509
Ensembl chr 7:21,903,126...21,905,993
G
Asic4
acid sensing ion channel subunit family member 4
increases expression
EXP
Ketamine results in increased expression of ASIC4 mRNA
CTD
PMID:20080153
NCBI chr 9:76,941,532...76,962,900
Ensembl chr 9:76,941,532...76,962,900
G
Aspdh
aspartate dehydrogenase domain containing
increases expression
EXP
Ketamine results in increased expression of ASPDH mRNA
CTD
PMID:20080153
NCBI chr 1:104,094,983...104,097,244
Ensembl chr 1:94,958,316...94,960,722
G
Atf4
activating transcription factor 4
increases expression
ISO
Ketamine results in increased expression of ATF4 mRNA
CTD
PMID:35728656
NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446
G
Atf6
activating transcription factor 6
increases expression
ISO
Ketamine results in increased expression of ATF6 mRNA
CTD
PMID:35728656
NCBI chr13:85,460,312...85,639,959
Ensembl chr13:82,930,034...83,107,177
G
Atg12
autophagy related 12
increases expression
EXP
Ketamine results in increased expression of ATG12 mRNA
CTD
PMID:20080153
NCBI chr18:41,638,841...41,649,311
Ensembl chr18:39,452,191...39,462,418
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Atp13a4
ATPase 13A4
increases expression
EXP
Ketamine results in increased expression of ATP13A4 mRNA
CTD
PMID:20080153
NCBI chr11:84,727,014...84,864,747
Ensembl chr11:71,226,161...71,359,933
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Atp1a1
ATPase Na+/K+ transporting subunit alpha 1
increases expression
EXP
Ketamine results in increased expression of ATP1A1 mRNA
CTD
PMID:20080153
NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:189,020,722...189,048,837
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Atp1a2
ATPase Na+/K+ transporting subunit alpha 2
increases expression
EXP
Ketamine results in increased expression of ATP1A2 mRNA
CTD
PMID:20080153
NCBI chr13:87,261,964...87,286,911
Ensembl chr13:84,729,601...84,754,544
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Atp1a3
ATPase Na+/K+ transporting subunit alpha 3
increases expression
EXP
Ketamine results in increased expression of ATP1A3 mRNA
CTD
PMID:20080153
NCBI chr 1:89,700,645...89,729,782
Ensembl chr 1:80,572,796...80,601,918
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Atp6v0a1
ATPase H+ transporting V0 subunit a1
increases expression
EXP
Ketamine results in increased expression of ATP6V0A1 mRNA
CTD
PMID:20080153
NCBI chr10:86,436,089...86,490,185
Ensembl chr10:85,935,854...85,989,895
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Atp6v1c2
ATPase H+ transporting V1 subunit C2
increases expression
EXP
Ketamine results in increased expression of ATP6V1C2 mRNA
CTD
PMID:20080153
NCBI chr 6:45,809,269...45,872,914
Ensembl chr 6:40,080,547...40,120,028
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Atp7a
ATPase copper transporting alpha
decreases expression
EXP
Ketamine results in decreased expression of ATP7A mRNA
CTD
PMID:20080153
NCBI chr X:75,159,635...75,267,094
Ensembl chr X:71,094,202...71,198,354
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B4gat1
beta-1,4-glucuronyltransferase 1
increases expression
EXP
Ketamine results in increased expression of B4GAT1 mRNA
CTD
PMID:20080153
NCBI chr 1:211,772,644...211,774,866
Ensembl chr 1:202,343,240...202,346,065
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Bace1
beta-secretase 1
increases expression multiple interactions
ISO
Ketamine results in increased expression of BACE1 protein Ketamine results in increased expression of and affects the localization of BACE1 protein; Monensin inhibits the reaction [Ketamine results in increased expression of and affects the localization of BACE1 protein]
CTD
PMID:35378374
NCBI chr 8:55,038,842...55,061,138
Ensembl chr 8:46,142,116...46,165,876
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Bag3
BAG cochaperone 3
increases expression
EXP
Ketamine results in increased expression of BAG3 mRNA
CTD
PMID:20080153
NCBI chr 1:192,533,460...192,557,281
Ensembl chr 1:183,102,871...183,126,858
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Bag5
BAG cochaperone 5
multiple interactions increases expression
EXP
BAG5 protein inhibits the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of CASP3 mRNA]]; lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of BAG5 mRNA]; lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of BAG5 protein]; MIR22 affects the reaction [Ketamine results in increased expression of BAG5 mRNA]; MIR22 affects the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of BAG5 protein]]; MIR22 inhibits the reaction [Ketamine results in increased expression of BAG5 protein] Ketamine results in increased expression of BAG5 mRNA; Ketamine results in increased expression of BAG5 protein
CTD
PMID:34670429
NCBI chr 6:136,589,623...136,593,278
Ensembl chr 6:130,768,141...130,772,970
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Baiap2
BAR/IMD domain containing adaptor protein 2
increases expression
EXP
Ketamine results in increased expression of BAIAP2 mRNA
CTD
PMID:20080153
NCBI chr10:105,721,371...105,788,549
Ensembl chr10:105,223,090...105,290,134
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Banp
Btg3 associated nuclear protein
decreases expression
EXP
Ketamine results in decreased expression of BANP mRNA
CTD
PMID:20080153
NCBI chr19:66,916,417...66,994,286
Ensembl chr19:50,007,881...50,082,738
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Bax
BCL2 associated X, apoptosis regulator
affects localization increases expression multiple interactions
ISO EXP
Ketamine affects the localization of BAX protein Ketamine results in increased expression of BAX mRNA; Ketamine results in increased expression of BAX protein Curcumin inhibits the reaction [Ketamine results in increased expression of BAX mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of BAX protein]; TRPV4 protein affects the reaction [Ketamine results in increased expression of BAX mRNA]; TRPV4 protein affects the reaction [Ketamine results in increased expression of BAX protein]
CTD
PMID:18456338 PMID:19001360 PMID:25937004 PMID:33536391 PMID:36305173
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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Bckdha
branched chain keto acid dehydrogenase E1 subunit alpha
increases expression
EXP
Ketamine results in increased expression of BCKDHA mRNA
CTD
PMID:20080153
NCBI chr 1:90,266,731...90,295,521
Ensembl chr 1:81,138,947...81,167,862
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Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
ISO EXP
LEP protein promotes the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in decreased expression of BCL2 protein]]; lipoxin A4 methyl ester inhibits the reaction [Ketamine results in decreased expression of BCL2 protein] Ketamine results in decreased expression of BCL2 mRNA; Ketamine results in decreased expression of BCL2 protein Curcumin affects the reaction [Ketamine results in decreased expression of BCL2 protein]; Curcumin inhibits the reaction [Ketamine results in decreased expression of BCL2 mRNA]; TRPV4 protein affects the reaction [Ketamine results in decreased expression of BCL2 mRNA]; TRPV4 protein affects the reaction [Ketamine results in decreased expression of BCL2 protein]
CTD
PMID:33536391 PMID:36305173 PMID:36907275
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bclaf3
BCLAF1 and THRAP3 family member 3
decreases expression
EXP
Ketamine results in decreased expression of BCLAF3 mRNA
CTD
PMID:20080153
NCBI chr X:39,065,842...39,137,521
Ensembl chr X:35,263,576...35,328,816
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Bcorl1
BCL6 co-repressor-like 1
decreases expression
EXP
Ketamine results in decreased expression of BCORL1 mRNA
CTD
PMID:20080153
NCBI chr X:132,394,703...132,462,414
Ensembl chr X:127,537,538...127,584,087
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Bcs1l
BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
decreases expression
EXP
Ketamine results in decreased expression of BCS1L mRNA
CTD
PMID:20080153
NCBI chr 9:83,614,045...83,618,052
Ensembl chr 9:76,164,932...76,168,938
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Bdkrb1
bradykinin receptor B1
increases expression
ISO
Ketamine results in increased expression of BDKRB1 mRNA; Ketamine results in increased expression of BDKRB1 protein
CTD
PMID:27638051
NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:124,510,870...124,513,747
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Bdnf
brain-derived neurotrophic factor
multiple interactions decreases expression increases expression
EXP ISO
Ketamine inhibits the reaction [Isoflurophate results in decreased expression of BDNF protein]; Ketamine inhibits the reaction [Pilocarpine results in increased expression of BDNF mRNA] Ketamine results in decreased expression of BDNF mRNA; Ketamine results in decreased expression of BDNF protein Sirolimus inhibits the reaction [Ketamine results in increased expression of BDNF protein]
CTD
PMID:8635431 PMID:32592718 PMID:33022268 PMID:36172893
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
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Becn1
beclin 1
increases expression
ISO
Ketamine results in increased expression of BECN1 protein
CTD
PMID:34487425
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742
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Bhlhe22
basic helix-loop-helix family, member e22
decreases expression
EXP
Ketamine results in decreased expression of BHLHE22 mRNA
CTD
PMID:20080153
NCBI chr 2:102,402,622...102,405,732
Ensembl chr 2:100,486,400...100,489,510
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Bhlhe40
basic helix-loop-helix family, member e40
increases expression
EXP
Ketamine results in increased expression of BHLHE40 mRNA
CTD
PMID:20080153
NCBI chr 4:143,174,450...143,180,150
Ensembl chr 4:141,618,476...141,624,774
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Bhlhe41
basic helix-loop-helix family, member e41
increases expression
EXP
Ketamine results in increased expression of BHLHE41 mRNA
CTD
PMID:20080153
NCBI chr 4:180,565,003...180,569,415
Ensembl chr 4:178,834,271...178,838,468
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Bmi1
BMI1 proto-oncogene, polycomb ring finger
decreases expression
EXP
Ketamine results in decreased expression of BMI1 mRNA
CTD
PMID:20080153
NCBI chr17:86,240,683...86,250,044
Ensembl chr17:81,332,214...81,388,690
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Bnip3
BCL2 interacting protein 3
decreases expression
EXP
Ketamine results in decreased expression of BNIP3 mRNA
CTD
PMID:20080153
NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359
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Braf
B-Raf proto-oncogene, serine/threonine kinase
multiple interactions
ISO
Ketamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of BRAF protein]
CTD
PMID:19540866
NCBI chr 4:69,329,772...69,476,931
Ensembl chr 4:68,384,649...68,510,463
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Brinp2
BMP/retinoic acid inducible neural specific 2
increases expression
EXP
Ketamine results in increased expression of BRINP2 mRNA
CTD
PMID:20080153
NCBI chr13:72,964,498...73,065,312
Ensembl chr13:70,431,010...70,531,810
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Btg1
BTG anti-proliferation factor 1
decreases expression multiple interactions
EXP
Ketamine results in decreased expression of BTG1 mRNA [ampullosporin co-treated with Ketamine] results in increased expression of BTG1 mRNA
CTD
PMID:16635253 PMID:20080153
NCBI chr 7:33,228,149...33,230,406
Ensembl chr 7:31,341,027...31,343,649
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Bub1b
BUB1 mitotic checkpoint serine/threonine kinase B
decreases expression
EXP
Ketamine results in decreased expression of BUB1B mRNA
CTD
PMID:20080153
NCBI chr 3:126,017,019...126,069,470
Ensembl chr 3:105,563,138...105,615,547
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C17h5orf24
similar to human chromosome 5 open reading frame 24
decreases expression
EXP
Ketamine results in decreased expression of C17H5ORF24 mRNA
CTD
PMID:20080153
NCBI chr17:8,928,209...8,938,126
Ensembl chr17:8,922,675...8,933,356
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C1qa
complement C1q A chain
increases expression
EXP
Ketamine results in increased expression of C1QA mRNA
CTD
PMID:20080153
NCBI chr 5:154,417,086...154,419,933
Ensembl chr 5:149,133,636...149,136,534
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C1qb
complement C1q B chain
increases expression
EXP
Ketamine results in increased expression of C1QB mRNA
CTD
PMID:20080153
NCBI chr 5:154,402,276...154,407,827
Ensembl chr 5:149,118,846...149,124,407
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C1qc
complement C1q C chain
increases expression multiple interactions decreases expression
EXP
Ketamine results in increased expression of C1QC mRNA Cannabidiol inhibits the reaction [Ketamine results in decreased expression of C1QC mRNA]
CTD
PMID:20080153 PMID:31823199
NCBI chr 5:154,410,845...154,414,208
Ensembl chr 5:149,127,415...149,131,017
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C2
complement C2
increases expression
EXP
Ketamine results in increased expression of C2 mRNA
CTD
PMID:20080153
NCBI chr20:3,944,722...3,975,006
Ensembl chr20:3,951,474...3,976,505
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C2cd2l
C2CD2-like
increases expression
EXP
Ketamine results in increased expression of C2CD2L mRNA
CTD
PMID:20080153
NCBI chr 8:53,544,887...53,557,127
Ensembl chr 8:44,648,079...44,658,340
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C2cd4b
C2 calcium-dependent domain containing 4B
increases expression
EXP
Ketamine results in increased expression of C2CD4B mRNA
CTD
PMID:20080153
NCBI chr 8:77,254,327...77,277,620
Ensembl chr 8:68,384,847...68,396,328
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C4bpb
complement component 4 binding protein, beta
increases expression
EXP
Ketamine results in increased expression of C4BPB mRNA
CTD
PMID:20080153
NCBI chr13:44,673,064...44,683,781
Ensembl chr13:42,120,798...42,131,817
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Caap1
caspase activity and apoptosis inhibitor 1
decreases expression
EXP
Ketamine results in decreased expression of CAAP1 mRNA
CTD
PMID:20080153
NCBI chr 5:114,428,991...114,530,047
Ensembl chr 5:109,361,912...109,414,314
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Cabcoco1
ciliary associated calcium binding coiled-coil 1
increases expression
EXP
Ketamine results in increased expression of CABCOCO1 mRNA
CTD
PMID:20080153
NCBI chr20:20,057,462...20,166,732
Ensembl chr20:20,058,454...20,167,725
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Cabp7
calcium binding protein 7
increases expression
EXP
Ketamine results in increased expression of CABP7 mRNA
CTD
PMID:20080153
NCBI chr14:83,822,322...83,832,667
Ensembl chr14:79,598,827...79,609,240
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Cacng2
calcium voltage-gated channel auxiliary subunit gamma 2
increases expression
EXP
Ketamine results in increased expression of CACNG2 mRNA
CTD
PMID:20080153
NCBI chr 7:111,451,605...111,579,071
Ensembl chr 7:109,574,459...109,697,227
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Calb2
calbindin 2
increases expression multiple interactions
EXP
Ketamine results in increased expression of CALB2 mRNA [ampullosporin co-treated with Ketamine] results in increased expression of CALB2 mRNA
CTD
PMID:16635253 PMID:20080153
NCBI chr19:55,023,849...55,050,858
Ensembl chr19:38,114,424...38,141,438
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Camkk1
calcium/calmodulin-dependent protein kinase kinase 1
increases expression
EXP
Ketamine results in increased expression of CAMKK1 mRNA
CTD
PMID:20080153
NCBI chr10:58,135,872...58,159,023
Ensembl chr10:57,637,391...57,660,498
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Camkk2
calcium/calmodulin-dependent protein kinase kinase 2
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of CAMKK2 mRNA
CTD
PMID:16635253
NCBI chr12:39,451,828...39,505,719
Ensembl chr12:33,791,052...33,843,279
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Cand2
cullin-associated and neddylation-dissociated 2 (putative)
decreases expression
EXP
Ketamine results in decreased expression of CAND2 mRNA
CTD
PMID:20080153
NCBI chr 4:148,835,050...148,864,039
Ensembl chr 4:148,835,053...148,863,153
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Cant1
calcium activated nucleotidase 1
increases expression
EXP
Ketamine results in increased expression of CANT1 mRNA
CTD
PMID:20080153
NCBI chr10:104,135,676...104,148,854
Ensembl chr10:103,531,504...103,650,109
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Car4
carbonic anhydrase 4
increases expression
EXP
Ketamine results in increased expression of CAR4 mRNA
CTD
PMID:20080153
NCBI chr10:70,325,102...70,333,916
Ensembl chr10:69,827,945...69,836,501
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Car7
carbonic anhydrase 7
increases expression
EXP
Ketamine results in increased expression of CAR7 mRNA
CTD
PMID:20080153
NCBI chr19:435,520...444,927
Ensembl chr19:429,075...438,467
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Car8
carbonic anhydrase 8
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of CAR8 mRNA
CTD
PMID:16635253
NCBI chr 5:26,102,767...26,199,819
Ensembl chr 5:21,305,383...21,402,374
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Casp3
caspase 3
increases cleavage increases activity multiple interactions increases expression
ISO EXP
Ketamine results in increased cleavage of CASP3 protein Ketamine results in increased activity of CASP3 protein BAG5 protein inhibits the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of CASP3 mRNA]]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 mRNA]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein modified form]; Curcumin inhibits the reaction [Ketamine results in increased expression of CASP3 protein]; lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased activity of CASP3 protein]; lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of CASP3 mRNA]; MIR22 affects the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of CASP3 mRNA]]; MIR22 inhibits the reaction [Ketamine results in increased activity of CASP3 protein]; TRPV4 protein affects the reaction [Ketamine results in increased cleavage of CASP3 protein]; TRPV4 protein affects the reaction [Ketamine results in increased expression of CASP3 mRNA] Ketamine results in increased expression of CASP3 mRNA; Ketamine results in increased expression of CASP3 protein; Ketamine results in increased expression of CASP3 protein modified form LEP protein promotes the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased cleavage of CASP3 protein]]; lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased cleavage of CASP3 protein]
CTD
PMID:17920787 PMID:19001360 PMID:25937004 PMID:32153215 PMID:33536391 PMID:34670429 PMID:36305173 PMID:36907275 More...
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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Casp6
caspase 6
increases activity
ISO
Ketamine results in increased activity of CASP6 protein
CTD
PMID:19001360
NCBI chr 2:221,140,287...221,152,727
Ensembl chr 2:218,466,076...218,478,502
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Casp9
caspase 9
increases activity multiple interactions increases expression
ISO EXP
Ketamine results in increased activity of CASP9 protein lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased activity of CASP9 protein]; lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of CASP9 mRNA]; MIR22 inhibits the reaction [Ketamine results in increased activity of CASP9 protein]
CTD
PMID:19001360 PMID:20080153 PMID:34670429
Ensembl chr 5:154,109,046...154,126,626
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Cat
catalase
decreases activity multiple interactions
EXP
Ketamine results in decreased activity of CAT protein TRPV4 protein affects the reaction [Ketamine results in decreased activity of CAT protein]
CTD
PMID:33536391
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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Cbr3
carbonyl reductase 3
decreases expression
EXP
Ketamine results in decreased expression of CBR3 mRNA
CTD
PMID:20080153
NCBI chr11:46,478,295...46,486,555
Ensembl chr11:33,008,615...33,016,875
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Cbx1
chromobox 1
decreases expression
EXP
Ketamine results in decreased expression of CBX1 mRNA
CTD
PMID:20080153
NCBI chr10:82,266,746...82,286,431
Ensembl chr10:81,770,342...81,791,096
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Cbx7
chromobox 7
increases expression
EXP
Ketamine results in increased expression of CBX7 mRNA
CTD
PMID:20080153
NCBI chr 7:113,341,030...113,358,716
Ensembl chr 7:111,460,656...111,477,973
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Ccdc115
coiled-coil domain containing 115
increases expression
EXP
Ketamine results in increased expression of VMA22 mRNA
CTD
PMID:20080153
NCBI chr 9:36,650,384...36,654,348
Ensembl chr 9:36,649,271...36,653,946
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Ccdc50
coiled-coil domain containing 50
decreases expression
EXP
Ketamine results in decreased expression of CCDC50 mRNA
CTD
PMID:20080153
NCBI chr11:86,837,624...86,900,164
Ensembl chr11:73,334,248...73,395,150
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Ccdc85a
coiled-coil domain containing 85A
decreases expression
EXP
Ketamine results in decreased expression of CCDC85A mRNA
CTD
PMID:20080153
NCBI chr14:106,327,580...106,560,205
Ensembl chr14:102,129,029...102,359,058
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Ccdc90b
coiled-coil domain containing 90B
decreases expression
EXP
Ketamine results in decreased expression of CCDC90B mRNA
CTD
PMID:20080153
NCBI chr 1:146,632,756...146,646,314
Ensembl chr 1:146,633,036...146,647,338
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Cck
cholecystokinin
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of CCK mRNA
CTD
PMID:16635253
NCBI chr 8:130,031,012...130,037,702
Ensembl chr 8:121,153,500...121,160,084
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Ccl5
C-C motif chemokine ligand 5
multiple interactions
ISO
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CCL5 protein]
CTD
PMID:22245128
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
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Ccna2
cyclin A2
decreases expression
EXP
Ketamine results in decreased expression of CCNA2 mRNA
CTD
PMID:20080153
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
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Ccnd1
cyclin D1
decreases expression
EXP
Ketamine results in decreased expression of CCND1 mRNA
CTD
PMID:20080153
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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Ccndbp1
cyclin D1 binding protein 1
decreases expression
EXP
Ketamine results in decreased expression of CCNDBP1 mRNA
CTD
PMID:20080153
NCBI chr 3:128,416,105...128,427,985
Ensembl chr 3:107,962,261...107,974,233
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Ccpg1
cell cycle progression 1
increases expression
EXP
Ketamine results in increased expression of CCPG1 mRNA
CTD
PMID:20080153
NCBI chr 8:82,600,677...82,633,082
Ensembl chr 8:73,719,955...73,752,430
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Ccr5
C-C motif chemokine receptor 5
increases expression
EXP
Ketamine results in increased expression of CCR5 mRNA
CTD
PMID:20080153
NCBI chr 8:132,629,097...132,660,980
Ensembl chr 8:123,752,325...123,759,260
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Ccsap
centriole, cilia and spindle-associated protein
increases expression
EXP
Ketamine results in increased expression of CCSAP mRNA
CTD
PMID:20080153
NCBI chr19:68,722,417...68,740,908
Ensembl chr19:51,826,994...51,842,753
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Cd24
CD24 molecule
decreases expression
EXP
Ketamine results in decreased expression of CD24 mRNA
CTD
PMID:20080153
NCBI chr20:48,655,549...48,661,786
Ensembl chr20:47,073,512...47,079,662
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Cd38
CD38 molecule
increases expression
EXP
Ketamine results in increased expression of CD38 mRNA
CTD
PMID:20080153
NCBI chr14:71,384,532...71,424,794
Ensembl chr14:67,172,063...67,211,986
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Cd63
Cd63 molecule
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of CD63 mRNA
CTD
PMID:16635253
NCBI chr 7:1,909,538...1,924,937
Ensembl chr 7:1,325,103...1,399,178
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Cd83
CD83 molecule
increases expression
EXP
Ketamine results in increased expression of CD83 mRNA
CTD
PMID:20080153
NCBI chr17:21,093,281...21,113,223
Ensembl chr17:20,887,309...20,907,083
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Cdc42ep3
CDC42 effector protein 3
decreases expression
EXP
Ketamine results in decreased expression of CDC42EP3 mRNA
CTD
PMID:20080153
NCBI chr 6:15,710,894...15,731,366
Ensembl chr 6:15,708,730...15,732,721
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Cdc6
cell division cycle 6
decreases expression
EXP
Ketamine results in decreased expression of CDC6 mRNA
CTD
PMID:20080153
NCBI chr10:84,360,361...84,374,239
Ensembl chr10:83,864,638...83,878,011
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Cdca7
cell division cycle associated 7
decreases expression
EXP
Ketamine results in decreased expression of CDCA7 mRNA
CTD
PMID:20080153
NCBI chr 3:77,730,315...77,740,950
Ensembl chr 3:57,322,708...57,333,353
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Cdh1
cadherin 1
multiple interactions decreases expression
ISO EXP
2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [Ketamine results in decreased expression of CDH1 protein] Ketamine results in decreased expression of CDH1 mRNA; Ketamine results in decreased expression of CDH1 protein
CTD
PMID:28331066
NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
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Cdh11
cadherin 11
decreases expression
EXP
Ketamine results in decreased expression of CDH11 mRNA
CTD
PMID:20080153
NCBI chr19:2,152,961...2,312,140
Ensembl chr19:2,148,458...2,304,272
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Cdh15
cadherin 15
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of CDH15 mRNA
CTD
PMID:16635253
NCBI chr19:67,812,169...67,834,986
Ensembl chr19:50,903,638...50,927,105
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Cdh7
cadherin 7
decreases expression
EXP
Ketamine results in decreased expression of CDH7 mRNA
CTD
PMID:20080153
NCBI chr13:27,186,223...27,336,076
Ensembl chr13:26,672,484...26,819,846
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Cdk1
cyclin-dependent kinase 1
decreases expression
EXP
Ketamine results in decreased expression of CDK1 mRNA
CTD
PMID:20080153
NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408
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Cdk14
cyclin-dependent kinase 14
decreases expression
EXP
Ketamine results in decreased expression of CDK14 mRNA
CTD
PMID:20080153
NCBI chr 4:29,619,237...30,213,651
Ensembl chr 4:28,666,843...29,258,861
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Cdnf
cerebral dopamine neurotrophic factor
affects expression
ISO
Ketamine affects the expression of CDNF mRNA
CTD
PMID:35728656
NCBI chr17:79,623,728...79,637,800
Ensembl chr17:74,713,564...74,728,639
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Cebpb
CCAAT/enhancer binding protein beta
increases expression
EXP
Ketamine results in increased expression of CEBPB mRNA
CTD
PMID:20080153
NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473
G
Cenpc
centromere protein C
decreases expression
EXP
Ketamine results in decreased expression of CENPC1 mRNA
CTD
PMID:20080153
NCBI chr14:22,342,910...22,401,522
Ensembl chr14:21,988,144...22,055,476
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Cep70
centrosomal protein 70
decreases expression
EXP
Ketamine results in decreased expression of CEP70 mRNA
CTD
PMID:20080153
NCBI chr 8:108,689,562...108,742,620
Ensembl chr 8:99,810,367...99,862,855
G
Cfap126
cilia and flagella associated protein 126
increases expression
EXP
Ketamine results in increased expression of CFAP126 mRNA
CTD
PMID:20080153
NCBI chr13:86,059,142...86,075,034
Ensembl chr13:83,526,657...83,542,552
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Cfap410
cilia and flagella associated protein 410
increases expression
EXP
Ketamine results in increased expression of CFAP410 mRNA
CTD
PMID:20080153
NCBI chr20:10,687,506...10,694,366
Ensembl chr20:10,687,863...10,694,737
G
Chd7
chromodomain helicase DNA binding protein 7
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of CHD7 mRNA
CTD
PMID:16635253
NCBI chr 5:26,609,245...26,792,736
Ensembl chr 5:21,812,070...21,995,358
G
Chi3l1
chitinase 3 like 1
increases expression
EXP
Ketamine results in increased expression of CHI3L1 mRNA
CTD
PMID:20080153
NCBI chr13:48,193,839...48,201,822
Ensembl chr13:45,641,802...45,649,787
G
Chordc1
cysteine and histidine rich domain containing 1
decreases expression
EXP
Ketamine results in decreased expression of CHORDC1 mRNA
CTD
PMID:20080153
NCBI chr 8:23,650,721...23,674,786
Ensembl chr 8:15,374,471...15,399,162
G
Chpf2
chondroitin polymerizing factor 2
increases expression
EXP
Ketamine results in increased expression of CHPF2 mRNA
CTD
PMID:20080153
NCBI chr 4:11,470,917...11,479,096
Ensembl chr 4:10,580,462...10,585,916
G
Chrm1
cholinergic receptor, muscarinic 1
multiple interactions
ISO
Ketamine inhibits the reaction [Scopolamine Derivatives binds to CHRM1 protein]
CTD
PMID:12456425
NCBI chr 1:214,996,180...215,012,136
Ensembl chr 1:205,567,220...205,582,356
G
Chrm2
cholinergic receptor, muscarinic 2
multiple interactions
ISO
Ketamine inhibits the reaction [Scopolamine Derivatives binds to CHRM2 protein]
CTD
PMID:12456425
NCBI chr 4:65,981,136...66,116,128
Ensembl chr 4:65,014,144...65,149,103
G
Chrm3
cholinergic receptor, muscarinic 3
multiple interactions
ISO
Ketamine inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]
CTD
PMID:12456425
NCBI chr17:64,696,549...65,158,622
Ensembl chr17:60,005,202...60,467,278
G
Ciao3
cytosolic iron-sulfur assembly component 3
increases expression
EXP
Ketamine results in increased expression of CIAO3 mRNA
CTD
PMID:20080153
NCBI chr10:15,300,403...15,309,467
Ensembl chr10:14,795,961...14,804,950
G
Cited2
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of CITED2 mRNA
CTD
PMID:16635253
NCBI chr 1:14,132,303...14,134,746
Ensembl chr 1:12,312,160...12,314,897
G
Cldn11
claudin 11
increases expression
EXP
Ketamine results in increased expression of CLDN11 mRNA
CTD
PMID:20080153
NCBI chr 2:114,136,234...114,149,539
Ensembl chr 2:112,207,745...112,221,050
G
Clec2l
C-type lectin domain family 2, member L
increases expression
EXP
Ketamine results in increased expression of CLEC2L mRNA
CTD
PMID:20080153
NCBI chr 4:67,392,118...67,414,539
Ensembl chr 4:67,397,873...67,414,537
G
Clec4a3
C-type lectin domain family 4, member A3
increases expression
EXP
Ketamine results in increased expression of CLEC4A3 mRNA
CTD
PMID:20080153
NCBI chr 4:157,885,899...157,896,728
Ensembl chr 4:156,214,718...156,224,817
G
Clk1
CDC-like kinase 1
decreases expression
EXP
Ketamine results in decreased expression of CLK1 mRNA
CTD
PMID:20080153
NCBI chr 9:67,441,962...67,453,180
Ensembl chr 9:59,947,764...59,957,000
G
Clmp
CXADR-like membrane protein
decreases expression
EXP
Ketamine results in decreased expression of CLMP mRNA
CTD
PMID:20080153
NCBI chr 8:49,957,639...50,065,959
Ensembl chr 8:41,060,799...41,168,838
G
Clu
clusterin
increases expression
EXP
Ketamine results in increased expression of CLU mRNA
CTD
PMID:20080153
NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315
G
Cmtm5
CKLF-like MARVEL transmembrane domain containing 5
increases expression
EXP
Ketamine results in increased expression of CMTM5 mRNA
CTD
PMID:20080153
NCBI chr15:28,412,624...28,415,304
Ensembl chr15:28,412,624...28,415,287
G
Cmtm8
CKLF-like MARVEL transmembrane domain containing 8
increases expression
EXP
Ketamine results in increased expression of CMTM8 mRNA
CTD
PMID:20080153
NCBI chr 8:114,481,730...114,547,107
Ensembl chr 8:114,481,982...114,547,083
G
Cnksr3
Cnksr family member 3
increases expression
EXP
Ketamine results in increased expression of CNKSR3 mRNA
CTD
PMID:20080153
NCBI chr 1:45,904,581...45,996,921
Ensembl chr 1:43,499,487...43,591,635
G
Cnr1
cannabinoid receptor 1
decreases expression
EXP
Ketamine results in decreased expression of CNR1 mRNA
CTD
PMID:20080153
NCBI chr 5:53,204,867...53,230,396
Ensembl chr 5:48,408,574...48,435,099
G
Coa4
cytochrome c oxidase assembly factor 4 homolog
decreases expression
EXP
Ketamine results in decreased expression of COA4 mRNA
CTD
PMID:20080153
NCBI chr 1:154,882,199...154,885,445
Ensembl chr 1:154,882,155...154,888,174
G
Coa7
cytochrome c oxidase assembly factor 7
increases expression
EXP
Ketamine results in increased expression of COA7 mRNA
CTD
PMID:20080153
NCBI chr 5:128,298,084...128,308,935
Ensembl chr 5:123,069,371...123,080,199
G
Cog6
component of oligomeric golgi complex 6
decreases expression
EXP
Ketamine results in decreased expression of COG6 mRNA
CTD
PMID:20080153
NCBI chr 2:137,062,127...137,099,176
Ensembl chr 2:137,061,346...137,099,190
G
Col11a1
collagen type XI alpha 1 chain
decreases expression
EXP
Ketamine results in decreased expression of COL11A1 mRNA
CTD
PMID:20080153
NCBI chr 2:204,509,136...204,702,264
Ensembl chr 2:201,820,715...202,013,853
G
Col18a1
collagen type XVIII alpha 1 chain
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of COL18A1 mRNA
CTD
PMID:16635253
NCBI chr20:11,473,645...11,582,111
Ensembl chr20:11,474,104...11,582,593
G
Commd5
COMM domain containing 5
increases expression
EXP
Ketamine results in increased expression of COMMD5 mRNA
CTD
PMID:20080153
NCBI chr 7:108,621,766...108,623,616
Ensembl chr 7:108,598,673...108,624,764
G
Comt
catechol-O-methyltransferase
increases expression
EXP
Ketamine results in increased expression of COMT mRNA
CTD
PMID:20080153
NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642
G
Coq8a
coenzyme Q8A
increases expression
EXP
Ketamine results in increased expression of COQ8A mRNA
CTD
PMID:20080153
NCBI chr13:94,436,680...94,465,535
Ensembl chr13:91,904,739...91,931,431
G
Cort
cortistatin
increases expression
EXP
Ketamine results in increased expression of CORT mRNA
CTD
PMID:20080153
NCBI chr 5:164,843,682...164,845,796
G
Cox6a2
cytochrome c oxidase subunit 6A2
increases expression
EXP
Ketamine results in increased expression of COX6A2 mRNA
CTD
PMID:20080153
NCBI chr 1:192,218,970...192,221,188
Ensembl chr 1:182,788,528...182,789,274
G
Cracdl
CRACD like
increases expression
EXP
Ketamine results in increased expression of CRACDL mRNA
CTD
PMID:20080153
NCBI chr 9:47,323,785...47,446,612
Ensembl chr 9:39,834,833...39,951,086
G
Crcp
CGRP receptor component
increases expression
EXP
Ketamine results in increased expression of CRCP mRNA
CTD
PMID:20080153
NCBI chr12:32,260,108...32,315,116
Ensembl chr12:26,623,976...26,768,225
G
Creg1
cellular repressor of E1A-stimulated genes 1
increases expression
EXP
Ketamine results in increased expression of CREG1 mRNA
CTD
PMID:20080153
NCBI chr13:80,552,779...80,565,272
Ensembl chr13:78,019,843...78,032,308
G
Creld2
cysteine-rich with EGF-like domains 2
decreases expression
EXP
Ketamine results in decreased expression of CRELD2 mRNA
CTD
PMID:20080153
NCBI chr 7:121,788,754...121,796,230
Ensembl chr 7:119,909,633...119,916,543
G
Crh
corticotropin releasing hormone
decreases expression
EXP
Ketamine results in decreased expression of CRH mRNA
CTD
PMID:20080153
NCBI chr 2:104,059,184...104,061,048
Ensembl chr 2:102,143,055...102,144,919
G
Crls1
cardiolipin synthase 1
decreases expression
EXP
Ketamine results in decreased expression of CRLS1 mRNA
CTD
PMID:20080153
NCBI chr 3:140,572,680...140,591,543
Ensembl chr 3:120,119,852...120,138,655
G
Crtac1
cartilage acidic protein 1
increases expression
EXP
Ketamine results in increased expression of CRTAC1 mRNA
CTD
PMID:20080153
NCBI chr 1:251,040,963...251,182,920
Ensembl chr 1:241,078,864...241,233,421
G
Cryab
crystallin, alpha B
increases expression
EXP
Ketamine results in increased expression of CRYAB mRNA
CTD
PMID:20080153
NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:51,093,441...51,099,157
G
Csf1r
colony stimulating factor 1 receptor
decreases expression
ISO
Ketamine results in decreased expression of CSF1R mRNA
CTD
PMID:36172893
NCBI chr18:56,834,152...56,860,804
Ensembl chr18:54,546,659...54,590,415
G
Csrp2
cysteine and glycine-rich protein 2
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of CSRP2 mRNA
CTD
PMID:16635253
NCBI chr 7:48,235,415...48,254,049
Ensembl chr 7:46,348,686...46,367,745
G
Ctnnb1
catenin beta 1
increases expression multiple interactions
EXP
Ketamine results in increased expression of CTNNB1 protein Chir 99021 promotes the reaction [Ketamine results in increased expression of CTNNB1 protein]
CTD
PMID:36334642
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
G
Ctse
cathepsin E
increases expression
EXP
Ketamine results in increased expression of CTSE mRNA
CTD
PMID:20080153
NCBI chr13:45,644,168...45,666,722
Ensembl chr13:43,092,128...43,114,502
G
Ctsk
cathepsin K
increases expression
EXP
Ketamine results in increased expression of CTSK mRNA
CTD
PMID:20080153
NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:183,058,569...183,069,550
G
Ctss
cathepsin S
increases expression
EXP
Ketamine results in increased expression of CTSS mRNA
CTD
PMID:20080153
NCBI chr 2:185,775,316...185,803,440
Ensembl chr 2:183,086,437...183,114,483
G
Cttnbp2nl
CTTNBP2 N-terminal like
decreases expression
EXP
Ketamine results in decreased expression of CTTNBP2NL mRNA
CTD
PMID:20080153
NCBI chr 2:192,507,963...192,554,548
Ensembl chr 2:192,507,963...192,541,101
G
Cx3cl1
C-X3-C motif chemokine ligand 1
increases expression
EXP
Ketamine results in increased expression of CX3CL1 mRNA
CTD
PMID:20080153
NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,227,340...10,236,833
G
Cx3cr1
C-X3-C motif chemokine receptor 1
decreases expression
ISO
Ketamine results in decreased expression of CX3CR1 mRNA; Ketamine results in decreased expression of CX3CR1 protein
CTD
PMID:36172893
NCBI chr 8:128,661,294...128,679,048
Ensembl chr 8:119,782,595...119,800,014
G
Cxcl3
C-X-C motif chemokine ligand 3
multiple interactions
ISO
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of CXCL1 protein]
CTD
PMID:22245128
NCBI chr14:17,571,900...17,573,624
Ensembl chr14:17,270,146...17,289,511
G
Cxxc4
CXXC finger protein 4
decreases expression
EXP
Ketamine results in decreased expression of CXXC4 mRNA
CTD
PMID:20080153
NCBI chr 2:225,329,044...225,363,347
Ensembl chr 2:222,664,771...222,689,365
G
Cyb5r3
cytochrome b5 reductase 3
increases expression
EXP
Ketamine results in increased expression of CYB5R3 mRNA
CTD
PMID:20080153
NCBI chr 7:116,186,729...116,204,290
Ensembl chr 7:114,306,685...114,324,298
G
Cyba
cytochrome b-245 alpha chain
increases expression
ISO
Ketamine results in increased expression of CYBA
CTD
PMID:18063801
NCBI chr19:67,396,143...67,404,214
Ensembl chr19:50,487,597...50,495,721
G
Cybb
cytochrome b-245 beta chain
increases expression
ISO
Ketamine results in increased expression of CYBB
CTD
PMID:18063801
NCBI chr X:16,030,596...16,065,065
Ensembl chr X:13,359,430...13,392,586
G
Cyfip2
cytoplasmic FMR1 interacting protein 2
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of CYFIP2 mRNA
CTD
PMID:16635253
NCBI chr10:31,122,653...31,242,440
Ensembl chr10:30,621,318...30,741,113
G
Cyp11a1
cytochrome P450, family 11, subfamily a, polypeptide 1
increases expression
EXP
Ketamine results in increased expression of CYP11A1 mRNA
CTD
PMID:20080153
NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
EXP
Ketamine results in increased expression of CYP1A1 protein
CTD
PMID:16076768
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
increases expression
EXP
Ketamine results in increased expression of CYP2B1 protein
CTD
PMID:16076768
NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
G
Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
increases expression
EXP
Ketamine results in increased expression of CYP2E1 protein
CTD
PMID:16076768
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
increases expression multiple interactions decreases expression
EXP ISO
Ketamine results in increased expression of CYP3A2 protein Ketamine results in decreased expression of and results in decreased activity of CYP3A4 protein Ketamine results in decreased expression of CYP3A4 mRNA
CTD
PMID:16076768 PMID:18845661
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
G
Cyp3a23-3a1
cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
increases expression
EXP
Ketamine results in increased expression of CYP3A23-3A1 protein
CTD
PMID:16076768
NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
G
Cyp46a1
cytochrome P450, family 46, subfamily a, polypeptide 1
increases expression
EXP
Ketamine results in increased expression of CYP46A1 mRNA
CTD
PMID:20080153
NCBI chr 6:133,011,948...133,039,167
Ensembl chr 6:127,243,315...127,274,760
G
Cyth4
cytohesin 4
decreases expression multiple interactions
EXP
Ketamine results in decreased expression of CYTH4 mRNA Cannabidiol inhibits the reaction [Ketamine results in decreased expression of CYTH4 mRNA]
CTD
PMID:31823199
NCBI chr 7:112,032,711...112,057,204
Ensembl chr 7:110,152,272...110,176,741
G
Daglb
diacylglycerol lipase, beta
decreases expression
EXP
Ketamine results in decreased expression of DAGLB mRNA
CTD
PMID:20080153
NCBI chr12:16,173,345...16,215,777
Ensembl chr12:11,059,732...11,102,154
G
Dao
D-amino-acid oxidase
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of DAO mRNA
CTD
PMID:16635253
NCBI chr12:48,252,900...48,275,964
Ensembl chr12:42,592,343...42,612,741
G
Dbndd1
dysbindin domain containing 1
decreases expression
EXP
Ketamine results in decreased expression of DBNDD1 mRNA
CTD
PMID:20080153
NCBI chr19:68,447,641...68,461,272
Ensembl chr19:51,539,148...51,548,444
G
Dcaf13
DDB1 and CUL4 associated factor 13
decreases expression
EXP
Ketamine results in decreased expression of DCAF13 mRNA
CTD
PMID:20080153
NCBI chr 7:72,045,828...72,081,039
Ensembl chr 7:70,160,941...70,196,142
G
Dctd
dCMP deaminase
decreases expression
EXP
Ketamine results in decreased expression of DCTD mRNA
CTD
PMID:20080153
NCBI chr16:50,799,699...50,831,398
Ensembl chr16:44,055,128...44,098,446
G
Dcx
doublecortin
decreases expression
ISO
Ketamine results in decreased expression of DCX protein
CTD
PMID:36172893
NCBI chr X:112,227,455...112,370,291
Ensembl chr X:107,430,767...107,507,476
G
Ddit3
DNA-damage inducible transcript 3
increases expression multiple interactions
ISO
Ketamine results in increased expression of DDIT3 protein LEP protein promotes the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of DDIT3 protein]]; lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of DDIT3 protein] Ketamine results in increased expression of DDIT3 mRNA
CTD
PMID:35728656 PMID:36907275
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
G
Ddx31
DEAD-box helicase 31
decreases expression
EXP
Ketamine results in decreased expression of DDX31 mRNA
CTD
PMID:20080153
NCBI chr 3:32,570,725...32,635,446
Ensembl chr 3:12,172,836...12,238,873
G
Defb1
defensin beta 1
decreases expression
EXP
Ketamine results in decreased expression of DEFB1 mRNA
CTD
PMID:20080153
NCBI chr16:77,001,326...77,016,068
Ensembl chr16:70,298,863...70,313,604
G
Dennd2b
DENN domain containing 2B
increases expression
EXP
Ketamine results in increased expression of DENND2B mRNA
CTD
PMID:20080153
NCBI chr 1:172,978,895...173,129,623
Ensembl chr 1:163,544,074...163,694,680
G
Dgat2
diacylglycerol O-acyltransferase 2
increases expression
EXP
Ketamine results in increased expression of DGAT2 mRNA
CTD
PMID:20080153
NCBI chr 1:162,866,237...162,896,655
Ensembl chr 1:153,454,080...153,484,428
G
Dgkg
diacylglycerol kinase, gamma
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of DGKG mRNA
CTD
PMID:16635253
NCBI chr11:91,888,957...92,083,715
Ensembl chr11:78,384,458...78,577,212
G
Dhodh
dihydroorotate dehydrogenase
decreases expression
EXP
Ketamine results in decreased expression of DHODH mRNA
CTD
PMID:20080153
NCBI chr19:54,460,636...54,483,049
Ensembl chr19:37,558,177...37,591,654
G
Dhx36
DEAH-box helicase 36
decreases expression
EXP
Ketamine results in decreased expression of DHX36 mRNA
CTD
PMID:20080153
NCBI chr 2:149,006,089...149,044,192
Ensembl chr 2:146,856,469...146,894,572
G
Dipk1a
divergent protein kinase domain 1A
increases expression
EXP
Ketamine results in increased expression of DIPK1A mRNA
CTD
PMID:20080153
NCBI chr14:1,917,353...1,988,188
Ensembl chr14:1,772,422...1,843,743
G
Dlg4
discs large MAGUK scaffold protein 4
decreases expression multiple interactions increases expression
ISO
Ketamine results in decreased expression of DLG4 protein Ketamine inhibits the reaction [Corticosterone results in decreased expression of DLG4 protein]; Sirolimus inhibits the reaction [Ketamine results in increased expression of DLG4 protein]
CTD
PMID:31470060 PMID:33022268 PMID:33872575 PMID:36172893
NCBI chr10:55,239,397...55,267,780
Ensembl chr10:54,739,470...54,767,153
G
Dlx5
distal-less homeobox 5
decreases expression
EXP
Ketamine results in decreased expression of DLX5 mRNA
CTD
PMID:20080153
NCBI chr 4:35,965,579...35,969,973
Ensembl chr 4:34,999,139...35,003,407
G
Dmac1
distal membrane arm assembly component 1
decreases expression
EXP
Ketamine results in decreased expression of DMAC1 mRNA
CTD
PMID:20080153
NCBI chr 5:89,241,173...89,243,793
Ensembl chr 5:89,242,661...89,243,757
G
Dmrtc1a
DMRT-like family C1a
increases expression
EXP
Ketamine results in increased expression of DMRTC1A mRNA
CTD
PMID:20080153
NCBI chr X:67,822,187...67,852,572
Ensembl chr X:67,822,113...67,852,571
G
Dmtf1
cyclin D binding myb-like transcription factor 1
decreases expression
EXP
Ketamine results in decreased expression of DMTF1 mRNA
CTD
PMID:20080153
NCBI chr 4:25,864,891...25,905,916
Ensembl chr 4:24,910,534...24,950,967
G
Dnajb14
DnaJ heat shock protein family (Hsp40) member B14
decreases expression
EXP
Ketamine results in decreased expression of DNAJB14 mRNA
CTD
PMID:20080153
NCBI chr 2:229,032,415...229,075,905
Ensembl chr 2:226,358,996...226,402,490
G
Dnajc15
DnaJ heat shock protein family (Hsp40) member C15
decreases expression
EXP
Ketamine results in decreased expression of DNAJC15 mRNA
CTD
PMID:20080153
NCBI chr15:53,182,060...53,249,675
Ensembl chr15:53,184,855...53,249,675
G
Dnm1
dynamin 1
increases expression
EXP
Ketamine results in increased expression of DNM1 mRNA
CTD
PMID:20080153
NCBI chr 3:36,002,535...36,055,220
Ensembl chr 3:15,604,784...15,648,538
G
Dnmt3b
DNA methyltransferase 3 beta
decreases expression
EXP
Ketamine results in decreased expression of DNMT3B mRNA
CTD
PMID:20080153
NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:142,130,592...142,169,124
G
Dock11
dedicator of cytokinesis 11
decreases expression
EXP
Ketamine results in decreased expression of DOCK11 mRNA
CTD
PMID:20080153
NCBI chr X:119,997,523...120,180,643
Ensembl chr X:115,131,909...115,314,854
G
Dph5
diphthamide biosynthesis 5
decreases expression
EXP
Ketamine results in decreased expression of DPH5 mRNA
CTD
PMID:20080153
NCBI chr 2:203,804,620...203,858,196
Ensembl chr 2:203,804,936...203,840,433
G
Dpysl3
dihydropyrimidinase-like 3
decreases expression
EXP
Ketamine results in decreased expression of DPYSL3 mRNA
CTD
PMID:20080153
NCBI chr18:35,625,357...35,731,152
Ensembl chr18:35,377,181...35,480,157
G
Dtx4
deltex E3 ubiquitin ligase 4
decreases expression
EXP
Ketamine results in decreased expression of DTX4 mRNA
CTD
PMID:20080153
NCBI chr 1:218,882,391...218,969,837
Ensembl chr 1:209,460,735...209,492,818
G
Dusp11
dual specificity phosphatase 11
decreases expression
EXP
Ketamine results in decreased expression of DUSP11 mRNA
CTD
PMID:20080153
NCBI chr 4:118,367,673...118,385,183
Ensembl chr 4:118,368,053...118,385,181
G
Dusp22
dual specificity phosphatase 22
increases expression
EXP
Ketamine results in increased expression of DUSP22 mRNA
CTD
PMID:20080153
NCBI chr17:33,989,637...34,040,021
Ensembl chr17:33,780,981...33,831,321
G
Dusp5
dual specificity phosphatase 5
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of CPG21 mRNA
CTD
PMID:16635253
NCBI chr 1:262,543,774...262,557,201
Ensembl chr 1:252,538,449...252,551,818
G
Dync2i2
dynein 2 intermediate chain 2
decreases expression
EXP
Ketamine results in decreased expression of DYNC2I2 mRNA
CTD
PMID:20080153
NCBI chr 3:33,703,882...33,719,960
Ensembl chr 3:13,306,039...13,322,121
G
Ears2
glutamyl-tRNA synthetase 2, mitochondrial
decreases expression
EXP
Ketamine results in decreased expression of EARS2 mRNA
CTD
PMID:20080153
NCBI chr 1:186,025,740...186,057,165
Ensembl chr 1:176,597,986...176,625,836
G
Ebp
EBP, cholestenol delta-isomerase
decreases expression
EXP
Ketamine results in decreased expression of EBP mRNA
CTD
PMID:20080153
NCBI chr X:16,971,372...16,977,782
Ensembl chr X:14,299,448...14,305,826
G
Ebpl
EBP like
decreases expression
EXP
Ketamine results in decreased expression of EBPL mRNA
CTD
PMID:20080153
NCBI chr15:39,684,140...39,707,537
Ensembl chr15:35,508,074...35,531,472
G
Echs1
enoyl-CoA hydratase, short chain 1
increases expression
EXP
Ketamine results in increased expression of ECHS1 protein
CTD
PMID:18504422
NCBI chr 1:204,324,679...204,333,506
Ensembl chr 1:194,895,036...194,903,884
G
Ect2
epithelial cell transforming 2
decreases expression
EXP
Ketamine results in decreased expression of ECT2 mRNA
CTD
PMID:20080153
NCBI chr 2:111,904,522...111,966,786
Ensembl chr 2:109,975,813...110,037,911
G
Edc3
enhancer of mRNA decapping 3
increases expression
EXP
Ketamine results in increased expression of EDC3 mRNA
CTD
PMID:20080153
NCBI chr 8:67,002,032...67,047,563
Ensembl chr 8:58,106,175...58,151,671
G
Eef2k
eukaryotic elongation factor-2 kinase
decreases expression
EXP
Ketamine results in decreased expression of EEF2K mRNA
CTD
PMID:20080153
NCBI chr 1:184,824,420...184,888,048
Ensembl chr 1:175,393,154...175,455,164
G
Efhb
EF hand domain family, member B
increases expression
EXP
Ketamine results in increased expression of EFHB mRNA
CTD
PMID:20080153
NCBI chr 9:6,608,791...6,680,104
Ensembl chr 9:6,372,194...6,441,919
G
Efna2
ephrin A2
decreases expression
EXP
Ketamine results in decreased expression of EFNA2 mRNA
CTD
PMID:20080153
NCBI chr 7:10,167,091...10,177,719
Ensembl chr 7:9,516,429...9,527,061
G
Egr4
early growth response 4
decreases expression
EXP
Ketamine results in decreased expression of EGR4 mRNA
CTD
PMID:20080153
NCBI chr 4:119,605,358...119,607,817
Ensembl chr 4:118,047,869...118,050,328
G
Eif1a
eukaryotic translation initiation factor 1A
decreases expression
EXP
Ketamine results in decreased expression of EIF1A mRNA
CTD
PMID:20080153
NCBI chr18:41,512,298...41,524,645
Ensembl chr18:39,325,202...39,338,696
G
Eif4e3
eukaryotic translation initiation factor 4E family member 3
decreases expression
EXP
Ketamine results in decreased expression of EIF4E3 mRNA
CTD
PMID:20080153
NCBI chr 4:133,709,802...133,858,398
Ensembl chr 4:132,258,502...132,301,808
G
Eno2
enolase 2
decreases expression
EXP
Ketamine results in decreased expression of ENO2 protein
CTD
PMID:18504422
NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:157,572,088...157,580,980
G
Enpp2
ectonucleotide pyrophosphatase/phosphodiesterase 2
increases expression
EXP
Ketamine results in increased expression of ENPP2 mRNA
CTD
PMID:20080153
NCBI chr 7:88,092,140...88,214,758
Ensembl chr 7:86,202,350...86,324,827
G
Entrep1
endosomal transmembrane epsin interactor 1
increases expression
EXP
Ketamine results in increased expression of ENTREP1 mRNA
CTD
PMID:20080153
NCBI chr 1:231,018,987...231,073,474
Ensembl chr 1:221,592,503...221,646,758
G
Ephx4
epoxide hydrolase 4
increases expression
EXP
Ketamine results in increased expression of EPHX4 mRNA
CTD
PMID:20080153
NCBI chr14:2,488,282...2,517,558
Ensembl chr14:2,340,248...2,373,022
G
Erbb4
erb-b2 receptor tyrosine kinase 4
decreases expression
ISO
Ketamine results in decreased expression of ERBB4 mRNA
CTD
PMID:20000043
NCBI chr 9:76,973,386...78,045,633
Ensembl chr 9:69,531,481...70,596,595
G
Erich1
glutamate-rich 1
decreases expression
EXP
Ketamine results in decreased expression of ERICH1 mRNA
CTD
PMID:20080153
NCBI chr16:82,203,536...82,271,361
Ensembl chr16:75,501,384...75,569,128
G
Ermp1
endoplasmic reticulum metallopeptidase 1
increases expression
EXP
Ketamine results in increased expression of ERMP1 mRNA
CTD
PMID:20080153
NCBI chr 1:236,801,459...236,835,656
Ensembl chr 1:227,387,920...227,436,909
G
Ezh1
enhancer of zeste 1 polycomb repressive complex 2 subunit
increases expression
EXP
Ketamine results in increased expression of EZH1 mRNA
CTD
PMID:20080153
NCBI chr10:86,626,307...86,662,257
Ensembl chr10:86,126,015...86,161,921
G
Ezh2
enhancer of zeste 2 polycomb repressive complex 2 subunit
decreases expression
EXP
Ketamine results in decreased expression of EZH2 mRNA
CTD
PMID:20080153
NCBI chr 4:77,624,223...77,698,598
Ensembl chr 4:76,624,399...76,687,362
G
Fam110d
family with sequence similarity 110, member D
decreases expression
EXP
Ketamine results in decreased expression of FAM110D mRNA
CTD
PMID:20080153
NCBI chr 5:146,471,048...146,474,019
Ensembl chr 5:146,471,049...146,474,056
G
Fam120b
family with sequence similarity 120 member B
decreases expression
EXP
Ketamine results in decreased expression of FAM120B mRNA
CTD
PMID:20080153
NCBI chr 1:56,320,015...56,385,064
Ensembl chr 1:56,339,129...56,385,061
G
Fam136a
family with sequence similarity 136, member A
decreases expression
EXP
Ketamine results in decreased expression of FAM136A mRNA
CTD
PMID:20080153
NCBI chr 4:120,362,563...120,368,479
Ensembl chr 4:118,805,127...118,811,047
G
Fam180a
family with sequence similarity 180, member A
decreases expression
EXP
Ketamine results in decreased expression of FAM180A mRNA
CTD
PMID:20080153
NCBI chr 4:64,959,999...64,975,176
Ensembl chr 4:63,992,867...64,008,047
G
Fam210a
family with sequence similarity 210, member A
decreases expression
EXP
Ketamine results in decreased expression of FAM210A mRNA
CTD
PMID:20080153
NCBI chr18:64,116,274...64,155,971
Ensembl chr18:61,852,907...61,886,171
G
Fam98a
family with sequence similarity 98, member A
decreases expression
EXP
Ketamine results in decreased expression of FAM98A mRNA
CTD
PMID:20080153
NCBI chr 6:25,626,108...25,640,767
Ensembl chr 6:19,874,071...19,888,742
G
Fat1
FAT atypical cadherin 1
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of FAT1 mRNA
CTD
PMID:16635253
NCBI chr16:53,909,759...54,029,175
Ensembl chr16:47,177,248...47,296,107
G
Fat3
FAT atypical cadherin 3
decreases expression
EXP
Ketamine results in decreased expression of FAT3 mRNA
CTD
PMID:20080153
NCBI chr 8:20,972,840...21,555,679
Ensembl chr 8:12,694,019...13,273,135
G
Fat4
FAT atypical cadherin 4
decreases expression
EXP
Ketamine results in decreased expression of FAT4 mRNA
CTD
PMID:20080153
NCBI chr 2:123,855,289...123,984,716
Ensembl chr 2:121,927,942...122,056,707
G
Faxc
failed axon connections homolog, metaxin like GST domain containing
increases expression
EXP
Ketamine results in increased expression of FAXC mRNA
CTD
PMID:20080153
NCBI chr 5:35,480,137...35,539,741
Ensembl chr 5:35,480,402...35,544,446
G
Fbl
fibrillarin
decreases expression
EXP
Ketamine results in decreased expression of FBL mRNA
CTD
PMID:20080153
NCBI chr 1:92,597,407...92,606,507
Ensembl chr 1:83,469,832...83,478,932
G
Fblim1
filamin binding LIM protein 1
decreases expression
EXP
Ketamine results in decreased expression of FBLIM1 mRNA
CTD
PMID:20080153
NCBI chr 5:159,167,004...159,198,578
Ensembl chr 5:153,883,960...153,913,757
G
Fbxl22
F-box and leucine-rich repeat protein 22
increases expression
EXP
Ketamine results in increased expression of FBXL22 mRNA
CTD
PMID:20080153
NCBI chr 8:75,965,027...75,971,714
Ensembl chr 8:67,069,998...67,076,685
G
Fbxo2
F-box protein 2
increases expression
EXP
Ketamine results in increased expression of FBXO2 mRNA
CTD
PMID:20080153
NCBI chr 5:163,876,079...163,881,508
Ensembl chr 5:158,592,925...158,598,355
G
Fbxo34
F-box protein 34
increases expression
EXP
Ketamine results in increased expression of FBXO34 mRNA
CTD
PMID:20080153
NCBI chr15:20,719,395...20,787,905
Ensembl chr15:20,710,629...20,787,222
G
Fbxo8
F-box protein 8
increases expression
EXP
Ketamine results in increased expression of FBXO8 mRNA
CTD
PMID:20080153
NCBI chr16:38,676,011...38,721,849
Ensembl chr16:33,665,306...33,711,272
G
Fdft1
farnesyl diphosphate farnesyl transferase 1
decreases expression
EXP
Ketamine results in decreased expression of FDFT1 mRNA
CTD
PMID:20080153
NCBI chr15:41,588,114...41,616,168
Ensembl chr15:37,412,146...37,440,287
G
Fem1b
fem-1 homolog B
increases expression
EXP
Ketamine results in increased expression of FEM1B mRNA
CTD
PMID:20080153
NCBI chr 8:72,160,722...72,173,996
Ensembl chr 8:63,265,301...63,278,577
G
Fgfr3
fibroblast growth factor receptor 3
increases expression
EXP
Ketamine results in increased expression of FGFR3 mRNA
CTD
PMID:20080153
NCBI chr14:81,211,800...81,227,215
Ensembl chr14:76,987,993...77,003,341
G
Fgfrl1
fibroblast growth factor receptor-like 1
decreases expression
EXP
Ketamine results in decreased expression of FGFRL1 mRNA
CTD
PMID:20080153
NCBI chr14:1,154,275...1,166,334
Ensembl chr14:1,009,786...1,021,928
G
Fkbp15
FKBP prolyl isomerase family member 15
increases expression
EXP
Ketamine results in increased expression of FKBP15 mRNA
CTD
PMID:20080153
NCBI chr 5:80,766,356...80,830,622
Ensembl chr 5:75,750,787...75,814,990
G
Fn1
fibronectin 1
increases expression multiple interactions
EXP ISO
Ketamine results in increased expression of FN1 protein 2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [Ketamine results in increased expression of FN1 protein] Ketamine results in increased expression of FN1 mRNA; Ketamine results in increased expression of FN1 protein
CTD
PMID:28331066
NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678
G
Fn3k
fructosamine 3 kinase
increases expression
EXP
Ketamine results in increased expression of FN3K mRNA
CTD
PMID:20080153
NCBI chr10:106,700,670...106,715,903
Ensembl chr10:106,700,670...106,715,895
G
Fos
Fos proto-oncogene, AP-1 transcription factor subunit
multiple interactions
EXP
Ketamine inhibits the reaction [Formaldehyde results in increased expression of FOS protein]
CTD
PMID:17551412
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
G
Foxo1
forkhead box O1
decreases expression
EXP
Ketamine results in decreased expression of FOXO1 mRNA
CTD
PMID:20080153
NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
G
Frem3
FRAS1 related extracellular matrix 3
increases expression
EXP
Ketamine results in increased expression of FREM3 mRNA
CTD
PMID:20080153
NCBI chr19:27,308,469...27,366,771
Ensembl chr19:27,308,469...27,366,771
G
Fshb
follicle stimulating hormone subunit beta
decreases expression
EXP
Ketamine results in decreased expression of FSHB protein
CTD
PMID:32153215
NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370
G
Fubp1
far upstream element binding protein 1
decreases expression
EXP
Ketamine results in decreased expression of FUBP1 mRNA
CTD
PMID:20080153
NCBI chr 2:243,819,529...243,846,544
Ensembl chr 2:241,159,512...241,186,602
G
Fxyd1
FXYD domain-containing ion transport regulator 1
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of FXYD1 mRNA
CTD
PMID:16635253
NCBI chr 1:95,414,556...95,418,645
Ensembl chr 1:86,287,165...86,291,278
G
Fxyd7
FXYD domain-containing ion transport regulator 7
increases expression
EXP
Ketamine results in increased expression of FXYD7 mRNA
CTD
PMID:20080153
NCBI chr 1:86,277,678...86,286,954
Ensembl chr 1:86,277,678...86,286,954
G
G0s2
G0/G1switch 2
decreases expression
EXP
Ketamine results in decreased expression of G0S2 mRNA
CTD
PMID:20080153
NCBI chr13:107,335,036...107,335,948
Ensembl chr13:104,806,156...104,807,451
G
Gabra5
gamma-aminobutyric acid type A receptor subunit alpha 5
increases expression
ISO
Ketamine results in increased expression of GABRA5 mRNA; Ketamine results in increased expression of GABRA5 protein
CTD
PMID:21712993
NCBI chr 1:117,404,446...117,517,424
Ensembl chr 1:108,268,776...108,380,917
G
Gabra6
gamma-aminobutyric acid type A receptor subunit alpha6
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of GABRA6 mRNA
CTD
PMID:16635253
NCBI chr10:27,311,965...27,327,337
Ensembl chr10:26,810,423...26,825,769
G
Gabrb2
gamma-aminobutyric acid type A receptor subunit beta 2
decreases expression
EXP
Ketamine results in decreased expression of GABRB2 mRNA
CTD
PMID:20080153
NCBI chr10:27,438,127...27,657,680
Ensembl chr10:26,936,551...27,151,251
G
Gabrd
gamma-aminobutyric acid type A receptor subunit delta
increases expression multiple interactions
EXP
Ketamine results in increased expression of GABRD mRNA [ampullosporin co-treated with Ketamine] results in increased expression of GABRD mRNA
CTD
PMID:16635253 PMID:20080153
NCBI chr 5:171,240,813...171,252,709
Ensembl chr 5:165,958,484...165,970,411
G
Gabrg2
gamma-aminobutyric acid type A receptor subunit gamma 2
decreases expression
EXP
Ketamine results in decreased expression of GABRG2 mRNA
CTD
PMID:20080153
NCBI chr10:26,876,926...26,965,523
Ensembl chr10:26,374,694...26,464,346
G
Gad1
glutamate decarboxylase 1
multiple interactions increases expression decreases expression
ISO
acetovanillone inhibits the reaction [Ketamine results in decreased expression of GAD1 protein] Ketamine results in increased expression of GAD1 mRNA
CTD
PMID:18063801 PMID:23660488
NCBI chr 3:75,777,260...75,818,099
Ensembl chr 3:55,369,704...55,410,333
G
Galnt16
polypeptide N-acetylgalactosaminyltransferase 16
increases expression
EXP
Ketamine results in increased expression of GALNT16 mRNA
CTD
PMID:20080153
NCBI chr 6:105,900,987...105,982,039
Ensembl chr 6:100,170,306...100,250,705
G
Galr2
galanin receptor 2
decreases expression
EXP
Ketamine results in decreased expression of GALR2 mRNA
CTD
PMID:20080153
NCBI chr10:102,012,086...102,016,057
Ensembl chr10:101,514,471...101,517,176
G
Gapdhs
glyceraldehyde-3-phosphate dehydrogenase, spermatogenic
increases expression
EXP
Ketamine results in increased expression of GAPDHS mRNA
CTD
PMID:20080153
NCBI chr 1:95,106,516...95,125,918
Ensembl chr 1:85,979,098...85,993,640
G
Garin5a
golgi associated RAB2 interactor 5A
increases expression
EXP
Ketamine results in increased expression of GARIN5A mRNA
CTD
PMID:20080153
NCBI chr 1:104,125,477...104,130,543
Ensembl chr 1:94,988,613...94,993,539
G
Gatad2b
GATA zinc finger domain containing 2B
decreases expression
EXP
Ketamine results in decreased expression of GATAD2B mRNA
CTD
PMID:20080153
NCBI chr 2:178,046,192...178,127,633
Ensembl chr 2:175,749,433...175,825,542
G
Gca
grancalcin
decreases expression
EXP
Ketamine results in decreased expression of GCA mRNA
CTD
PMID:20080153
NCBI chr 3:47,297,320...47,329,913
Ensembl chr 3:47,297,383...47,328,581
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression multiple interactions decreases expression
EXP
Ketamine results in increased expression of GCLC mRNA Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of GCLC protein] Ketamine results in decreased expression of GCLC mRNA; Ketamine results in decreased expression of GCLC protein
CTD
PMID:20080153 PMID:36305173
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
G
Gdap1l1
ganglioside-induced differentiation-associated protein 1-like 1
increases expression
EXP
Ketamine results in increased expression of GDAP1L1 mRNA
CTD
PMID:20080153
NCBI chr 3:152,110,225...152,129,693
Ensembl chr 3:152,110,253...152,128,711
G
Gfap
glial fibrillary acidic protein
increases expression
EXP
Ketamine results in increased expression of GFAP mRNA
CTD
PMID:20080153
NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589
G
Gfod2
Gfo/Idh/MocA-like oxidoreductase domain containing 2
decreases expression
EXP
Ketamine results in decreased expression of GFOD2 mRNA
CTD
PMID:20080153
NCBI chr19:33,599,689...33,647,060
Ensembl chr19:33,604,187...33,647,004
G
Gfpt2
glutamine-fructose-6-phosphate transaminase 2
decreases expression
EXP
Ketamine results in decreased expression of GFPT2 mRNA
CTD
PMID:20080153
NCBI chr10:34,616,146...34,662,420
Ensembl chr10:34,115,052...34,161,329
G
Gfra2
GDNF family receptor alpha 2
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of GFRA2 mRNA
CTD
PMID:16635253
NCBI chr15:52,351,499...52,443,369
Ensembl chr15:45,941,828...46,033,714
G
Ggact
gamma-glutamylamine cyclotransferase
increases expression
EXP
Ketamine results in increased expression of GGACT mRNA
CTD
PMID:20080153
NCBI chr15:106,375,924...106,406,649
Ensembl chr15:99,968,282...99,993,455
G
Gjb6
gap junction protein, beta 6
increases expression
EXP
Ketamine results in increased expression of GJB6 mRNA
CTD
PMID:20080153
NCBI chr15:35,400,147...35,410,649
Ensembl chr15:31,284,419...31,294,582
G
Glul
glutamate-ammonia ligase
increases expression multiple interactions
EXP ISO
Ketamine results in increased expression of GLUL protein [Guanosine co-treated with Ketamine] results in increased activity of GLUL protein
CTD
PMID:18504422 PMID:36878458
NCBI chr13:68,519,500...68,585,554
Ensembl chr13:66,025,630...66,035,108
G
Gpr22
G protein-coupled receptor 22
increases expression
EXP
Ketamine results in increased expression of GPR22 mRNA
CTD
PMID:20080153
NCBI chr 6:54,037,998...54,044,994
Ensembl chr 6:48,310,505...48,317,486
G
Gpr37l1
G protein-coupled receptor 37-like 1
increases expression
EXP
Ketamine results in increased expression of GPR37L1 mRNA
CTD
PMID:20080153
NCBI chr13:49,150,355...49,157,204
Ensembl chr13:46,598,578...46,605,421
G
Gpr84
G protein-coupled receptor 84
multiple interactions decreases expression
EXP
Cannabidiol inhibits the reaction [Ketamine results in decreased expression of GPR84 mRNA]
CTD
PMID:31823199
NCBI chr 7:136,322,374...136,324,648
Ensembl chr 7:134,443,936...134,446,178
G
Gpr85
G protein-coupled receptor 85
decreases expression
EXP
Ketamine results in decreased expression of GPR85 mRNA
CTD
PMID:20080153
NCBI chr 4:42,100,138...42,109,584
Ensembl chr 4:42,102,941...42,109,566
G
Gria1
glutamate ionotropic receptor AMPA type subunit 1
increases expression multiple interactions decreases expression
EXP ISO
Ketamine increases expression of Gria1 protein on hippocampal formation, prefrontal cortex cell surface Ketamine promotes the reaction [Methamphetamine increases expression of Gria1 protein in hippocampus, striatum] Ketamine inhibits the reaction [Corticosterone results in decreased expression of GRIA1 protein]; MAPT protein affects the reaction [Ketamine results in decreased expression of GRIA1 protein]
CTD RGD
PMID:31470060 PMID:33872575 PMID:23303054 PMID:37778205
RGD:405650674 , RGD:405100237
NCBI chr10:41,710,540...42,030,105
Ensembl chr10:41,210,713...41,527,283
G
Gria2
glutamate ionotropic receptor AMPA type subunit 2
multiple interactions decreases expression
ISO
MAPT protein affects the reaction [Ketamine results in decreased expression of GRIA2 protein]
CTD
PMID:31470060
NCBI chr 2:168,247,490...168,367,616
Ensembl chr 2:165,947,521...166,069,510
G
Grid2
glutamate ionotropic receptor delta type subunit 2
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of GRID2 mRNA
CTD
PMID:16635253
NCBI chr 4:93,745,165...95,222,354
Ensembl chr 4:92,415,230...93,889,355
G
Grik5
glutamate ionotropic receptor kainate type subunit 5
increases expression
EXP
Ketamine results in increased expression of GRIK5 mRNA
CTD
PMID:20080153
NCBI chr 1:89,733,736...89,795,769
Ensembl chr 1:80,605,892...80,667,125
G
Grin1
glutamate ionotropic receptor NMDA type subunit 1
increases expression
EXP
Ketamine results in increased expression of GRIN1 mRNA; Ketamine results in increased expression of GRIN1 protein
CTD
PMID:19126600 PMID:20080153 PMID:23065140
NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:8,103,680...8,130,603
G
Grin2a
glutamate ionotropic receptor NMDA type subunit 2A
affects response to substance increases expression
ISO EXP
GRIN2A protein affects the susceptibility to Ketamine Ketamine results in increased expression of GRIN2A mRNA
CTD
PMID:15731593 PMID:20080153
NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637
G
Grin2b
glutamate ionotropic receptor NMDA type subunit 2B
multiple interactions decreases expression
EXP ISO
Ketamine inhibits the reaction [remifentanil results in increased phosphorylation of GRIN2B protein] Ketamine results in decreased expression of GRIN2B protein
CTD
PMID:20042082 PMID:36172893
NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:168,599,546...169,042,279
G
Grin2c
glutamate ionotropic receptor NMDA type subunit 2C
increases expression
EXP
Ketamine results in increased expression of GRIN2C mRNA
CTD
PMID:20080153
NCBI chr10:100,987,410...101,006,064
Ensembl chr10:100,488,431...100,506,427
G
Grm1
glutamate metabotropic receptor 1
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of GRM1 mRNA
CTD
PMID:16635253
NCBI chr 1:6,878,542...7,273,447
Ensembl chr 1:5,058,292...5,453,170
G
Grm3
glutamate metabotropic receptor 3
decreases expression
EXP
Ketamine results in decreased expression of GRM3 mRNA
CTD
PMID:20080153
NCBI chr 4:25,319,218...25,600,721
Ensembl chr 4:24,365,115...24,609,804
G
Grm4
glutamate metabotropic receptor 4
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of GRM4 mRNA
CTD
PMID:16635253
NCBI chr20:5,486,024...5,574,668
Ensembl chr20:5,481,124...5,572,821
G
Gsk3b
glycogen synthase kinase 3 beta
decreases phosphorylation increases phosphorylation multiple interactions
EXP
Ketamine results in decreased phosphorylation of GSK3B protein Ketamine results in increased phosphorylation of GSK3B protein Chir 99021 inhibits the reaction [Ketamine results in increased phosphorylation of GSK3B protein]
CTD
PMID:17952604 PMID:36334642
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
G
Gsto2
glutathione S-transferase omega 2
increases expression
EXP
Ketamine results in increased expression of GSTO2 mRNA
CTD
PMID:20080153
NCBI chr 1:256,673,376...256,695,154
Ensembl chr 1:246,732,089...246,753,866
G
Gtf2h3
general transcription factor IIH subunit 3
decreases expression
EXP
Ketamine results in decreased expression of GTF2H3 mRNA
CTD
PMID:20080153
NCBI chr12:37,669,995...37,687,505
Ensembl chr12:32,009,014...32,025,497
G
Gtf2ird1
GTF2I repeat domain containing 1
increases expression
EXP
Ketamine results in increased expression of GTF2IRD1 mRNA
CTD
PMID:20080153
NCBI chr12:22,254,113...22,361,052
Ensembl chr12:22,254,221...22,361,040
G
Gucy1b1
guanylate cyclase 1 soluble subunit beta 1
decreases expression
EXP
Ketamine results in decreased expression of GUCY1B1 mRNA
CTD
PMID:20080153
NCBI chr 2:169,646,897...169,697,060
Ensembl chr 2:167,348,825...167,398,916
G
H1f0
H1.0 linker histone
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of H1F0 mRNA
CTD
PMID:16635253
NCBI chr 7:112,473,280...112,475,140
Ensembl chr 7:110,592,208...110,594,694
G
H1f4
H1.4 linker histone, cluster member
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of H1F4 mRNA
CTD
PMID:16635253
NCBI chr17:41,914,425...41,915,206
Ensembl chr17:41,486,560...41,487,403
G
Habp4
hyaluronan binding protein 4
increases expression
EXP
Ketamine results in increased expression of HABP4 mRNA
CTD
PMID:20080153
NCBI chr17:940,672...963,358
Ensembl chr17:935,654...957,565
G
Hacd3
3-hydroxyacyl-CoA dehydratase 3
decreases expression
EXP
Ketamine results in decreased expression of HACD3 mRNA
CTD
PMID:20080153
NCBI chr 8:74,396,441...74,433,700
Ensembl chr 8:65,501,240...65,538,507
G
Hap1
huntingtin-associated protein 1
increases expression
EXP
Ketamine results in increased expression of HAP1 mRNA
CTD
PMID:20080153
NCBI chr10:85,778,267...85,786,553
Ensembl chr10:85,277,890...85,286,126
G
Haus8
HAUS augmin-like complex, subunit 8
decreases expression
EXP
Ketamine results in decreased expression of HAUS8 mRNA
CTD
PMID:20080153
NCBI chr16:17,964,813...17,979,313
Ensembl chr16:17,930,820...17,945,237
G
Havcr1
hepatitis A virus cellular receptor 1
multiple interactions
ISO
[Ketamine co-treated with Xylazine] results in increased secretion of HAVCR1 protein
CTD
PMID:30538007
NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698
G
Hbb
hemoglobin subunit beta
decreases expression
EXP
Ketamine results in decreased expression of HBB-B1 mRNA
CTD
PMID:20080153
NCBI chr 1:167,662,310...167,663,721
Ensembl chr 1:158,120,200...158,252,012
G
Hecw1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
decreases expression
EXP
Ketamine results in decreased expression of HECW1 mRNA
CTD
PMID:20080153
NCBI chr17:55,366,904...55,780,028
Ensembl chr17:50,670,954...51,080,720
G
Hes5
hes family bHLH transcription factor 5
decreases expression
EXP
Ketamine results in decreased expression of HES5 mRNA
CTD
PMID:20080153
NCBI chr 5:170,804,511...170,807,988
Ensembl chr 5:165,522,234...165,523,001
G
Hes6
hes family bHLH transcription factor 6
decreases expression
EXP
Ketamine results in decreased expression of HES6 mRNA
CTD
PMID:20080153
NCBI chr 9:99,449,375...99,451,343
Ensembl chr 9:92,001,841...92,003,559
G
Hexb
hexosaminidase subunit beta
decreases expression
ISO
Ketamine results in decreased expression of HEXB mRNA
CTD
PMID:36172893
NCBI chr 2:30,218,608...30,238,771
Ensembl chr 2:28,484,012...28,504,223
G
Hibch
3-hydroxyisobutyryl-CoA hydrolase
decreases expression
EXP
Ketamine results in decreased expression of HIBCH mRNA
CTD
PMID:20080153
NCBI chr 9:56,082,082...56,161,796
Ensembl chr 9:48,590,099...48,669,824
G
Hmgcll1
3-hydroxy-3-methylglutaryl-CoA lyase like 1
decreases expression
EXP
Ketamine results in decreased expression of HMGCLL1 mRNA
CTD
PMID:20080153
NCBI chr 8:85,637,708...85,799,759
Ensembl chr 8:76,757,497...76,886,816
G
Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
decreases expression
EXP
Ketamine results in decreased expression of HMGCR mRNA
CTD
PMID:20080153
NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703
G
Hmgcs2
3-hydroxy-3-methylglutaryl-CoA synthase 2
increases expression
EXP
Ketamine results in increased expression of HMGCS2 mRNA
CTD
PMID:20080153
NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:185,875,616...185,902,130
G
Hmgn1
high mobility group nucleosome binding domain 1
decreases expression
EXP
Ketamine results in decreased expression of HMGN1 mRNA
CTD
PMID:20080153
NCBI chr11:48,891,813...48,897,732
Ensembl chr11:35,422,328...35,428,254
G
Hmgn3
high mobility group nucleosomal binding domain 3
increases expression
EXP
Ketamine results in increased expression of HMGN3 mRNA
CTD
PMID:20080153
NCBI chr 8:92,902,555...92,939,980
Ensembl chr 8:84,022,495...84,062,976
G
Hmox1
heme oxygenase 1
decreases expression multiple interactions
EXP
Ketamine results in decreased expression of HMOX1 mRNA; Ketamine results in decreased expression of HMOX1 protein Curcumin inhibits the reaction [Ketamine results in decreased expression of HMOX1 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of HMOX1 protein]
CTD
PMID:36305173
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
G
Hmox2
heme oxygenase 2
increases expression
EXP
Ketamine results in increased expression of HMOX2 mRNA
CTD
PMID:20080153
NCBI chr10:11,303,512...11,337,640
Ensembl chr10:10,797,055...10,831,148
G
Hnrnpa2b1
heterogeneous nuclear ribonucleoprotein A2/B1
increases expression
EXP
Ketamine results in increased expression of HNRNPA2B1 protein
CTD
PMID:18504422
NCBI chr 4:81,867,354...81,875,886
Ensembl chr 4:80,534,651...80,545,249
G
Hnrnph3
heterogeneous nuclear ribonucleoprotein H3
decreases expression
EXP
Ketamine results in decreased expression of HNRNPH3 mRNA
CTD
PMID:20080153
NCBI chr20:25,619,540...25,624,397
Ensembl chr20:25,614,733...25,625,750
G
Hopx
HOP homeobox
increases expression
EXP
Ketamine results in increased expression of HOPX mRNA
CTD
PMID:20080153
NCBI chr14:31,410,235...31,437,189
Ensembl chr14:31,075,148...31,082,909
G
Hpca
hippocalcin
increases expression
EXP
Ketamine results in increased expression of HPCA mRNA
CTD
PMID:20080153
NCBI chr 5:146,739,978...146,750,961
Ensembl chr 5:141,455,613...141,463,841
G
Hpcal1
hippocalcin-like 1
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of HPCAL1 mRNA
CTD
PMID:16635253
NCBI chr 6:46,206,809...46,313,364
Ensembl chr 6:40,478,208...40,584,687
G
Hpdl
4-hydroxyphenylpyruvate dioxygenase-like
decreases expression
EXP
Ketamine results in decreased expression of HPDL mRNA
CTD
PMID:20080153
NCBI chr 5:135,523,258...135,524,864
Ensembl chr 5:130,286,631...130,288,233
G
Hpgd
15-hydroxyprostaglandin dehydrogenase
decreases expression
EXP
Ketamine results in decreased expression of HPGD mRNA
CTD
PMID:20080153
NCBI chr16:38,996,876...39,034,831
Ensembl chr16:33,986,266...34,024,228
G
Hras
HRas proto-oncogene, GTPase
multiple interactions
ISO
Ketamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of HRAS protein]
CTD
PMID:19540866
NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615
G
Hrh3
histamine receptor H3
increases expression
EXP
Ketamine results in increased expression of HRH3 mRNA
CTD
PMID:20080153
NCBI chr 3:187,569,174...187,575,263
Ensembl chr 3:167,191,558...167,196,642
G
Hrk
harakiri, BCL2 interacting protein
increases expression
EXP
Ketamine results in increased expression of HRK mRNA
CTD
PMID:20080153
NCBI chr12:44,048,402...44,070,561
G
Hs3st5
heparan sulfate-glucosamine 3-sulfotransferase 5
decreases expression
EXP
Ketamine results in decreased expression of HS3ST5 mRNA
CTD
PMID:20080153
NCBI chr20:41,661,785...41,972,550
Ensembl chr20:40,106,876...40,417,653
G
Hsd11b1
hydroxysteroid 11-beta dehydrogenase 1
increases expression
EXP
Ketamine results in increased expression of HSD11B1 mRNA
CTD
PMID:20080153
NCBI chr13:107,277,526...107,327,462
Ensembl chr13:104,728,539...104,788,687
G
Hsd17b4
hydroxysteroid (17-beta) dehydrogenase 4
decreases expression
EXP
Ketamine results in decreased expression of HSD17B4 mRNA
CTD
PMID:20080153
NCBI chr18:45,515,427...45,604,467
Ensembl chr18:43,328,824...43,417,952
G
Hspa2
heat shock protein family A (Hsp70) member 2
increases expression
EXP
Ketamine results in increased expression of HSPA2 mRNA
CTD
PMID:20080153
NCBI chr 6:100,864,172...100,866,946
Ensembl chr 6:95,128,350...95,131,287
G
Hspa5
heat shock protein family A (Hsp70) member 5
decreases expression multiple interactions increases expression affects expression
EXP ISO
Ketamine results in decreased expression of HSPA5 mRNA LEP protein promotes the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of HSPA5 protein]]; lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of HSPA5 protein] Ketamine affects the expression of HSPA5 mRNA
CTD
PMID:20080153 PMID:35728656 PMID:36907275
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
G
Htra1
HtrA serine peptidase 1
increases expression
EXP
Ketamine results in increased expression of HTRA1 mRNA
CTD
PMID:20080153
NCBI chr 1:194,928,069...194,977,619
Ensembl chr 1:185,497,735...185,547,379
G
Icam1
intercellular adhesion molecule 1
multiple interactions
ISO
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of ICAM1 protein]
CTD
PMID:22245128
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
G
Icam5
intercellular adhesion molecule 5
increases expression
EXP
Ketamine results in increased expression of ICAM5 mRNA
CTD
PMID:20080153
NCBI chr 8:27,843,563...27,851,767
Ensembl chr 8:19,568,600...19,575,588
G
Idh1
isocitrate dehydrogenase (NADP(+)) 1
decreases expression
EXP
Ketamine results in decreased expression of IDH1 mRNA
CTD
PMID:20080153
NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:66,534,146...66,563,708
G
Idi1
isopentenyl-diphosphate delta isomerase 1
decreases expression
EXP
Ketamine results in decreased expression of IDI1 mRNA
CTD
PMID:20080153
NCBI chr17:66,539,761...66,547,524
Ensembl chr17:61,629,594...61,637,357
G
Ifi27
interferon, alpha-inducible protein 27
increases expression
EXP
Ketamine results in increased expression of IFI27 mRNA
CTD
PMID:20080153
NCBI chr 6:128,355,312...128,361,783
Ensembl chr 6:122,590,472...122,779,294
G
Ifi27l2a
interferon, alpha-inducible protein 27 like 2A
increases expression
EXP
Ketamine results in increased expression of IFI27L1 mRNA
CTD
PMID:20080153
NCBI chr 6:128,363,658...128,365,144
Ensembl chr 6:122,598,872...122,600,360
G
Ifitm10
interferon induced transmembrane protein 10
increases expression
EXP
Ketamine results in increased expression of IFITM10 mRNA
CTD
PMID:20080153
NCBI chr 1:206,936,979...206,954,594
Ensembl chr 1:197,507,503...197,525,151
G
Ifngr1
interferon gamma receptor 1
increases expression
EXP
Ketamine results in increased expression of IFNGR1 mRNA
CTD
PMID:20080153
NCBI chr 1:16,152,811...16,171,439
Ensembl chr 1:14,333,187...14,351,785
G
Ifngr2
interferon gamma receptor 2
increases expression
EXP
Ketamine results in increased expression of IFNGR2 mRNA
CTD
PMID:20080153
NCBI chr11:44,265,703...44,283,975
Ensembl chr11:30,779,733...30,798,005
G
Igf2
insulin-like growth factor 2
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of IGF2 mRNA
CTD
PMID:16635253
NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:197,814,410...197,823,018
G
Igfbp1
insulin-like growth factor binding protein 1
increases expression
EXP
Ketamine results in increased expression of IGFBP1 mRNA
CTD
PMID:20080153
NCBI chr14:86,261,277...86,266,344
Ensembl chr14:82,047,415...82,052,482
G
Igfbp2
insulin-like growth factor binding protein 2
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of IGFBP2 mRNA
CTD
PMID:16635253
NCBI chr 9:81,864,811...81,892,179
Ensembl chr 9:74,415,546...74,442,937
G
Igfbp3
insulin-like growth factor binding protein 3
increases expression
EXP
Ketamine results in increased expression of IGFBP3 mRNA
CTD
PMID:20080153
NCBI chr14:86,270,208...86,277,944
Ensembl chr14:82,056,347...82,064,083
G
Igfbpl1
insulin-like growth factor binding protein-like 1
decreases expression
EXP
Ketamine results in decreased expression of IGFBPL1 mRNA
CTD
PMID:20080153
NCBI chr 5:60,076,428...60,091,833
Ensembl chr 5:60,076,429...60,091,833
G
Igsf9
immunoglobulin superfamily, member 9
decreases expression
EXP
Ketamine results in decreased expression of IGSF9 mRNA
CTD
PMID:20080153
NCBI chr13:87,480,979...87,497,974
Ensembl chr13:84,948,619...84,965,607
G
Ikbip
IKBKB interacting protein
decreases expression
EXP
Ketamine results in decreased expression of IKBIP mRNA
CTD
PMID:20080153
NCBI chr 7:27,467,097...27,485,776
Ensembl chr 7:25,579,832...25,605,162
G
Il12a
interleukin 12A
increases expression
EXP
Ketamine results in increased expression of IL12A mRNA
CTD
PMID:20080153
NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734
G
Il1b
interleukin 1 beta
increases expression increases secretion multiple interactions
EXP ISO
Ketamine results in increased expression of IL1B mRNA; Ketamine results in increased expression of IL1B protein Ketamine results in increased secretion of IL1B protein [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of IL1B protein]; Ketamine inhibits the reaction [Acetaminophen results in increased expression of IL1B protein]; Ketamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; Ketamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; TLR4 mutant form promotes the reaction [Ketamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; TLR4 mutant form promotes the reaction [Ketamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]] Ozone inhibits the reaction [Ketamine results in increased expression of IL1B mRNA]; TRPV4 protein affects the reaction [Ketamine results in increased expression of IL1B protein]
CTD
PMID:15207037 PMID:15207038 PMID:19540866 PMID:22245128 PMID:33536391 PMID:34487425 PMID:37491939 PMID:37515540 More...
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions increases expression affects response to substance
ISO EXP
Ketamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] TRPV4 protein affects the reaction [Ketamine results in increased expression of IL6 protein] [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 mRNA]; [Atropine co-treated with Ketamine] inhibits the reaction [Soman results in increased expression of IL6 protein]; Ketamine inhibits the reaction [Acetaminophen results in increased expression of IL6 protein]; Ketamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; mangiferin inhibits the reaction [Ketamine results in increased expression of IL6 protein] Ketamine results in increased expression of IL6 mRNA; Ketamine results in increased expression of IL6 protein IL6 affects the susceptibility to Ketamine
CTD
PMID:15207037 PMID:15207038 PMID:15720977 PMID:19091984 PMID:19540866 PMID:22245128 PMID:23087136 PMID:33536391 PMID:34487425 PMID:37491939 More...
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
G
Ina
internexin neuronal intermediate filament protein, alpha
increases expression
EXP
Ketamine results in increased expression of INA protein
CTD
PMID:18504422
NCBI chr 1:255,838,129...255,849,680
Ensembl chr 1:245,896,775...245,908,330
G
Ing2
inhibitor of growth family, member 2
increases expression
EXP
Ketamine results in increased expression of ING2 mRNA
CTD
PMID:20080153
NCBI chr16:51,305,311...51,316,177
Ensembl chr16:44,575,597...44,583,482
G
Inhba
inhibin subunit beta A
decreases expression
EXP
Ketamine results in decreased expression of INHBA mRNA
CTD
PMID:20080153
NCBI chr17:53,787,159...53,810,942
Ensembl chr17:49,095,920...49,108,982
G
Ino80c
INO80 complex subunit C
increases expression
EXP
Ketamine results in increased expression of INO80C mRNA
CTD
PMID:20080153
NCBI chr18:15,653,508...15,752,455
Ensembl chr18:15,378,770...15,393,403
G
Inpp5d
inositol polyphosphate-5-phosphatase D
increases expression
EXP
Ketamine results in increased expression of INPP5D mRNA
CTD
PMID:20080153
NCBI chr 9:95,735,533...95,840,584
Ensembl chr 9:88,287,677...88,392,746
G
Inpp5f
inositol polyphosphate-5-phosphatase F
decreases expression
EXP
Ketamine results in decreased expression of INPP5F mRNA
CTD
PMID:20080153
NCBI chr 1:192,620,891...192,700,681
Ensembl chr 1:183,190,480...183,270,276
G
Ints3
integrator complex subunit 3
decreases expression
EXP
Ketamine results in decreased expression of INTS3 mRNA
CTD
PMID:20080153
NCBI chr 2:178,157,015...178,209,263
Ensembl chr 2:175,859,440...175,911,709
G
Isyna1
inositol-3-phosphate synthase 1
decreases expression
EXP
Ketamine results in decreased expression of ISYNA1 mRNA
CTD
PMID:20080153
NCBI chr16:18,873,119...18,876,116
Ensembl chr16:18,839,145...18,841,979
G
Itih3
inter-alpha trypsin inhibitor, heavy chain 3
increases expression
EXP
Ketamine results in increased expression of ITIH3 mRNA
CTD
PMID:20080153
NCBI chr16:6,108,378...6,123,609
Ensembl chr16:6,101,930...6,116,924
G
Itm2c
integral membrane protein 2C
increases expression
EXP
Ketamine results in increased expression of ITM2C mRNA
CTD
PMID:20080153
NCBI chr 9:93,993,922...94,007,737
Ensembl chr 9:86,545,921...86,559,742
G
Itpka
inositol-trisphosphate 3-kinase A
increases expression
EXP
Ketamine results in increased expression of ITPKA mRNA
CTD
PMID:20080153
NCBI chr 3:127,179,841...127,188,405
Ensembl chr 3:106,726,036...106,734,600
G
Ivns1abp
influenza virus NS1A binding protein
decreases expression
EXP
Ketamine results in decreased expression of IVNS1ABP mRNA
CTD
PMID:20080153
NCBI chr13:65,977,069...65,996,685
Ensembl chr13:63,427,041...63,446,701
G
Jade3
jade family PHD finger 3
decreases expression
EXP
Ketamine results in decreased expression of JADE3 mRNA
CTD
PMID:20080153
NCBI chr X:4,222,369...4,424,164
Ensembl chr X:1,669,930...1,845,138
G
Jag2
jagged canonical Notch ligand 2
decreases expression
EXP
Ketamine results in decreased expression of JAG2 mRNA
CTD
PMID:20080153
NCBI chr 6:137,804,133...137,826,738
Ensembl chr 6:131,983,056...132,005,818
G
Jak2
Janus kinase 2
decreases expression
EXP
Ketamine results in decreased expression of JAK2 mRNA
CTD
PMID:20080153
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
G
Jmjd1c
jumonji domain containing 1C
decreases expression
EXP
Ketamine results in decreased expression of JMJD1C mRNA
CTD
PMID:20080153
NCBI chr20:21,330,990...21,508,580
Ensembl chr20:21,332,147...21,463,122
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
EXP
Ketamine results in increased expression of JUN mRNA
CTD
PMID:20080153
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
G
Kazald1
Kazal-type serine peptidase inhibitor domain 1
increases expression
EXP
Ketamine results in increased expression of KAZALD1 mRNA
CTD
PMID:20080153
NCBI chr 1:243,939,596...243,943,060
Ensembl chr 1:243,939,647...243,943,059
G
Kazn
kazrin, periplakin interacting protein
increases expression
EXP
Ketamine results in increased expression of KAZN mRNA
CTD
PMID:20080153
NCBI chr 5:154,392,793...155,381,567
Ensembl chr 5:154,392,793...154,779,074
G
Kcnc1
potassium voltage-gated channel subfamily C member 1
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of KCNC1 mRNA
CTD
PMID:16635253
NCBI chr 1:106,039,247...106,081,034
Ensembl chr 1:96,902,953...96,944,744
G
Kcnc2
potassium voltage-gated channel subfamily C member 2
decreases expression
EXP
Ketamine results in decreased expression of KCNC2 mRNA
CTD
PMID:20080153
NCBI chr 7:49,586,274...49,770,212
Ensembl chr 7:47,700,288...47,883,968
G
Kcng1
potassium voltage-gated channel modifier subfamily G member 1
decreases expression
EXP
Ketamine results in decreased expression of KCNG1 mRNA
CTD
PMID:20080153
NCBI chr 3:177,379,593...177,412,986
Ensembl chr 3:156,973,156...156,992,635
G
Kcnip2
potassium voltage-gated channel interacting protein 2
increases expression
EXP
Ketamine results in increased expression of KCNIP2 mRNA
CTD
PMID:20080153
NCBI chr 1:254,590,172...254,614,437
Ensembl chr 1:244,641,150...244,664,874
G
Kcnj12
potassium inwardly-rectifying channel, subfamily J, member 12
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of KCNJ12 mRNA
CTD
PMID:16635253
NCBI chr10:45,696,621...45,745,528
Ensembl chr10:45,696,849...45,745,492
G
Kcnj14
potassium inwardly-rectifying channel, subfamily J, member 14
decreases expression
EXP
Ketamine results in decreased expression of KCNJ14 mRNA
CTD
PMID:20080153
NCBI chr 1:96,293,159...96,300,810
Ensembl chr 1:96,293,435...96,495,459
G
Kcnmb4
potassium calcium-activated channel subfamily M regulatory beta subunit 4
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of KCNMB4 mRNA
CTD
PMID:16635253
NCBI chr 7:53,952,150...54,005,101
Ensembl chr 7:52,066,136...52,119,278
G
Kcns3
potassium voltage-gated channel, modifier subfamily S, member 3
decreases expression
EXP
Ketamine results in decreased expression of KCNS3 mRNA
CTD
PMID:20080153
NCBI chr 6:39,527,410...39,584,105
Ensembl chr 6:33,808,216...33,865,125
G
Kiaa0319
KIAA0319 homolog
decreases expression
EXP
Ketamine results in decreased expression of KIAA0319 mRNA
CTD
PMID:20080153
NCBI chr17:40,587,001...40,654,525
Ensembl chr17:40,165,084...40,225,653
G
Kif11
kinesin family member 11
decreases expression
EXP
Ketamine results in decreased expression of KIF11 mRNA
CTD
PMID:20080153
NCBI chr 1:244,494,916...244,589,250
Ensembl chr 1:235,124,316...235,176,766
G
Kif13a
kinesin family member 13A
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of KIF13A mRNA
CTD
PMID:16635253
NCBI chr17:17,972,227...18,154,763
Ensembl chr17:17,766,597...17,943,615
G
Kif20a
kinesin family member 20A
decreases expression
EXP
Ketamine results in decreased expression of KIF20A mRNA
CTD
PMID:20080153
NCBI chr18:26,504,422...26,512,908
Ensembl chr18:26,230,230...26,238,780
G
Kifc2
kinesin family member C2
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of KIFC2 mRNA
CTD
PMID:16635253
NCBI chr 7:110,261,257...110,269,007
Ensembl chr 7:108,376,011...108,388,484
G
Klf15
KLF transcription factor 15
increases expression
EXP
Ketamine results in increased expression of KLF15 mRNA
CTD
PMID:20080153
NCBI chr 4:124,522,652...124,535,613
Ensembl chr 4:122,965,807...122,978,374
G
Klf6
KLF transcription factor 6
decreases expression
EXP
Ketamine results in decreased expression of KLF6 mRNA
CTD
PMID:20080153
NCBI chr17:69,449,483...69,458,478
Ensembl chr17:64,531,463...64,588,570
G
Klf9
KLF transcription factor 9
increases expression
EXP
Ketamine results in increased expression of KLF9 mRNA
CTD
PMID:20080153
NCBI chr 1:230,126,646...230,151,641
Ensembl chr 1:220,700,108...220,725,037
G
Klhdc1
kelch domain containing 1
decreases expression
EXP
Ketamine results in decreased expression of KLHDC1 mRNA
CTD
PMID:20080153
NCBI chr 6:87,670,182...87,765,431
Ensembl chr 6:87,712,772...87,765,424
G
Klhdc9
kelch domain containing 9
increases expression
EXP
Ketamine results in increased expression of KLHDC9 mRNA
CTD
PMID:20080153
NCBI chr13:86,323,004...86,326,237
Ensembl chr13:83,790,269...83,793,354
G
Klhl24
kelch-like family member 24
decreases expression
EXP
Ketamine results in decreased expression of KLHL24 mRNA
CTD
PMID:20080153
NCBI chr11:94,348,024...94,382,085
Ensembl chr11:80,846,755...80,877,636
G
Klhl7
kelch-like family member 7
decreases expression
EXP
Ketamine results in decreased expression of KLHL7 mRNA
CTD
PMID:20080153
NCBI chr 4:11,898,766...11,947,796
Ensembl chr 4:11,006,375...11,055,541
G
Klhl8
kelch-like family member 8
decreases expression
EXP
Ketamine results in decreased expression of KLHL8 mRNA
CTD
PMID:20080153
NCBI chr14:5,807,795...5,853,325
Ensembl chr14:5,807,907...5,853,294
G
Klhl9
kelch-like family member 9
decreases expression
EXP
Ketamine results in decreased expression of KLHL9 mRNA
CTD
PMID:20080153
NCBI chr 5:108,449,492...108,453,676
G
Klk6
kallikrein related-peptidase 6
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of KLK6 mRNA
CTD
PMID:16635253
NCBI chr 1:103,415,411...103,422,682
Ensembl chr 1:94,280,340...94,286,121
G
Kmt5a
lysine methyltransferase 5A
decreases expression
EXP
Ketamine results in decreased expression of KMT5A mRNA
CTD
PMID:20080153
NCBI chr12:37,800,339...37,823,706
Ensembl chr12:32,139,178...32,162,711
G
Kng1
kininogen 1
multiple interactions
ISO
Ketamine inhibits the reaction [KNG1 protein results in increased expression of OCLN protein]
CTD
PMID:27638051
NCBI chr11:91,317,354...91,340,148
Ensembl chr11:77,812,752...77,835,555
G
Knstrn
kinetochore-localized astrin/SPAG5 binding protein
decreases expression
EXP
Ketamine results in decreased expression of KNSTRN mRNA
CTD
PMID:20080153
NCBI chr 3:126,254,633...126,274,412
Ensembl chr 3:105,800,954...105,820,715
G
Kpna2
karyopherin subunit alpha 2
decreases expression
EXP
Ketamine results in decreased expression of KPNA2 mRNA
CTD
PMID:20080153
NCBI chr10:92,433,678...92,445,841
Ensembl chr10:91,933,951...91,946,150
G
Kpnb1
karyopherin subunit beta 1
decreases expression
EXP
Ketamine results in decreased expression of KPNB1 mRNA
CTD
PMID:20080153
NCBI chr10:82,642,082...82,670,856
Ensembl chr10:82,145,420...82,174,605
G
Ktn1
kinectin 1
decreases expression
EXP
Ketamine results in decreased expression of KTN1 mRNA
CTD
PMID:20080153
NCBI chr15:23,392,570...23,485,061
Ensembl chr15:20,914,642...21,002,578
G
Lamb1
laminin subunit beta 1
decreases expression
EXP
Ketamine results in decreased expression of LAMB1 mRNA
CTD
PMID:20080153
NCBI chr 6:53,562,849...53,630,118
Ensembl chr 6:47,835,525...47,902,585
G
Lamp5
lysosomal-associated membrane protein family, member 5
increases expression
EXP
Ketamine results in increased expression of LAMP5 mRNA
CTD
PMID:20080153
NCBI chr 3:143,825,197...143,837,699
Ensembl chr 3:123,372,462...123,384,952
G
Laptm4b
lysosomal protein transmembrane 4 beta
increases expression
EXP
Ketamine results in increased expression of LAPTM4B mRNA
CTD
PMID:20080153
NCBI chr 7:67,319,438...67,362,547
Ensembl chr 7:65,434,394...65,477,383
G
Laptm5
lysosomal protein transmembrane 5
increases expression
EXP
Ketamine results in increased expression of LAPTM5 mRNA
CTD
PMID:20080153
NCBI chr 5:148,371,880...148,393,927
Ensembl chr 5:143,087,759...143,109,807
G
Lbp
lipopolysaccharide binding protein
multiple interactions
ISO
Ketamine inhibits the reaction [Lipopolysaccharides binds to LBP protein]
CTD
PMID:19540866
NCBI chr 3:167,373,786...167,400,941
Ensembl chr 3:146,954,015...146,981,586
G
Lcn2
lipocalin 2
multiple interactions
ISO
[Ketamine co-treated with Xylazine] results in decreased secretion of LCN2 protein
CTD
PMID:30538007
NCBI chr 3:36,078,432...36,081,851
Ensembl chr 3:15,680,687...15,684,095
G
Ldhb
lactate dehydrogenase B
decreases expression
EXP
Ketamine results in decreased expression of LDHB protein
CTD
PMID:18504422
NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:175,428,385...175,446,403
G
Leng8
leukocyte receptor cluster member 8
decreases expression
EXP
Ketamine results in decreased expression of LENG8 mRNA
CTD
PMID:20080153
NCBI chr 1:79,113,038...79,124,868
Ensembl chr 1:70,040,785...70,052,488
G
Lep
leptin
decreases expression multiple interactions
ISO
Ketamine results in decreased expression of LEP protein LEP protein promotes the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in decreased expression of BCL2 protein]]; LEP protein promotes the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased cleavage of CASP3 protein]]; LEP protein promotes the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of DDIT3 protein]]; LEP protein promotes the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of HSPA5 protein]]; lipoxin A4 methyl ester inhibits the reaction [Ketamine results in decreased expression of LEP protein]
CTD
PMID:36907275
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
G
Lepr
leptin receptor
multiple interactions decreases expression
ISO
lipoxin A4 methyl ester inhibits the reaction [Ketamine results in decreased expression of LEPR protein]
CTD
PMID:36907275
NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
G
Lgals1
galectin 1
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of LGALS1 mRNA
CTD
PMID:16635253
NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:110,481,392...110,488,345
G
Lgals3bp
galectin 3 binding protein
increases expression
EXP
Ketamine results in increased expression of LGALS3BP mRNA
CTD
PMID:20080153
NCBI chr10:104,118,510...104,127,848
Ensembl chr10:103,619,908...103,629,256
G
Lgi4
leucine-rich repeat LGI family, member 4
increases expression
EXP
Ketamine results in increased expression of LGI4 mRNA
CTD
PMID:20080153
NCBI chr 1:95,422,461...95,433,296
Ensembl chr 1:86,295,074...86,304,874
G
Lhb
luteinizing hormone subunit beta
decreases expression
EXP
Ketamine results in decreased expression of LHB protein
CTD
PMID:32153215
NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
G
Lin7b
lin-7 homolog B, crumbs cell polarity complex component
increases expression
EXP
Ketamine results in increased expression of LIN7B mRNA
CTD
PMID:20080153
NCBI chr 1:104,983,368...104,986,795
Ensembl chr 1:95,846,243...95,849,977
G
Lix1l
limb and CNS expressed 1 like
decreases expression
EXP
Ketamine results in decreased expression of LIX1L mRNA
CTD
PMID:20080153
NCBI chr 2:186,824,864...186,850,761
Ensembl chr 2:184,136,038...184,161,916
G
Lmbr1
limb development membrane protein 1
increases expression
EXP
Ketamine results in increased expression of LMBR1 mRNA
CTD
PMID:20080153
NCBI chr 4:6,649,824...6,820,525
Ensembl chr 4:5,974,750...6,146,368
G
Lmcd1
LIM and cysteine-rich domains 1
increases expression
EXP
Ketamine results in increased expression of LMCD1 mRNA
CTD
PMID:20080153
NCBI chr 4:146,948,993...147,007,878
Ensembl chr 4:145,393,145...145,452,046
G
Lrpap1
LDL receptor related protein associated protein 1
increases expression
EXP
Ketamine results in increased expression of LRPAP1 mRNA
CTD
PMID:20080153
NCBI chr14:79,876,002...79,888,011
Ensembl chr14:75,651,376...75,665,414
G
Lrrc42
leucine rich repeat containing 42
decreases expression
EXP
Ketamine results in decreased expression of LRRC42 mRNA
CTD
PMID:20080153
NCBI chr 5:122,014,678...122,035,792
Ensembl chr 5:122,014,678...122,035,829
G
Lrrc55
leucine rich repeat containing 55
decreases expression
EXP
Ketamine results in decreased expression of LRRC55 mRNA
CTD
PMID:20080153
NCBI chr 3:90,676,547...90,687,392
Ensembl chr 3:70,265,936...70,278,639
G
Lsm10
LSM10, U7 small nuclear RNA associated
decreases expression
EXP
Ketamine results in decreased expression of LSM10 mRNA
CTD
PMID:20080153
NCBI chr 5:143,649,817...143,660,391
Ensembl chr 5:138,373,119...138,377,505
G
Luc7l
LUC7-like
decreases expression
EXP
Ketamine results in decreased expression of LUC7L mRNA
CTD
PMID:20080153
NCBI chr10:15,777,837...15,811,586
Ensembl chr10:15,273,348...15,303,112
G
Lypd3
Ly6/Plaur domain containing 3
decreases expression
EXP
Ketamine results in decreased expression of LYPD3 mRNA
CTD
PMID:20080153
NCBI chr 1:89,354,354...89,358,806
Ensembl chr 1:80,226,449...80,230,901
G
Lzts1
leucine zipper tumor suppressor 1
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of LZTS1 mRNA
CTD
PMID:16635253
NCBI chr16:25,309,502...25,364,942
Ensembl chr16:20,542,809...20,598,203
G
Mab21l2
mab-21 like 2
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of MAB21L2 mRNA
CTD
PMID:16635253
NCBI chr 2:174,244,538...174,247,620
Ensembl chr 2:171,946,573...171,949,655
G
Mal
mal, T-cell differentiation protein
increases expression
EXP
Ketamine results in increased expression of MAL mRNA
CTD
PMID:20080153
NCBI chr 3:135,317,664...135,341,423
Ensembl chr 3:114,864,378...114,888,136
G
Man2b1
mannosidase, alpha, class 2B, member 1
increases expression
EXP
Ketamine results in increased expression of MAN2B1 mRNA
CTD
PMID:20080153
NCBI chr19:39,959,964...39,979,299
Ensembl chr19:23,055,097...23,074,389
G
Manf
mesencephalic astrocyte-derived neurotrophic factor
decreases expression
EXP ISO
Ketamine results in decreased expression of MANF mRNA
CTD
PMID:20080153 PMID:35728656
NCBI chr 8:116,427,053...116,430,259
Ensembl chr 8:107,548,352...107,551,438
G
Map1b
microtubule-associated protein 1B
decreases expression
EXP
Ketamine results in decreased expression of MAP1B mRNA
CTD
PMID:20080153
NCBI chr 2:32,551,423...32,644,471
Ensembl chr 2:30,817,261...30,910,317
G
Map2k1
mitogen activated protein kinase kinase 1
multiple interactions
ISO
Ketamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAP2K1 protein]
CTD
PMID:19540866
NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147
G
Map2k2
mitogen activated protein kinase kinase 2
multiple interactions
ISO
Ketamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of MAP2K2 protein]
CTD
PMID:19540866
NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:8,580,905...8,610,243
G
Map6
microtubule-associated protein 6
increases expression
EXP
Ketamine results in increased expression of MAP6 mRNA
CTD
PMID:20080153
NCBI chr 1:162,980,339...163,046,548
Ensembl chr 1:153,568,368...153,634,414
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
Ketamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD
PMID:19540866
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
Ketamine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
CTD
PMID:19540866
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
G
Mapk7
mitogen-activated protein kinase 7
decreases expression
EXP
Ketamine results in decreased expression of MAPK7 mRNA
CTD
PMID:20080153
NCBI chr10:46,669,721...46,675,768
Ensembl chr10:46,170,167...46,176,267
G
Mapt
microtubule-associated protein tau
increases phosphorylation multiple interactions
ISO
Ketamine results in increased phosphorylation of MAPT protein MAPT protein affects the reaction [Ketamine results in decreased expression of GRIA1 protein]; MAPT protein affects the reaction [Ketamine results in decreased expression of GRIA2 protein]
CTD
PMID:20093173 PMID:31470060
NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129
G
Marf1
meiosis regulator and mRNA stability factor 1
decreases expression
EXP
Ketamine results in decreased expression of MARF1 mRNA
CTD
PMID:20080153
NCBI chr10:1,395,271...1,439,974
Ensembl chr10:888,076...932,753
G
Mas1
MAS1 proto-oncogene, G protein-coupled receptor
decreases expression
EXP
Ketamine results in decreased expression of MAS1 mRNA
CTD
PMID:20080153
NCBI chr 1:50,428,064...50,459,537
Ensembl chr 1:47,880,309...47,911,709
G
Matk
megakaryocyte-associated tyrosine kinase
increases expression
EXP
Ketamine results in increased expression of MATK mRNA
CTD
PMID:20080153
NCBI chr 7:9,107,711...9,116,864
Ensembl chr 7:8,456,998...8,462,022
G
Mavs
mitochondrial antiviral signaling protein
decreases expression
EXP
Ketamine results in decreased expression of MAVS mRNA
CTD
PMID:20080153
NCBI chr 3:138,904,673...138,919,129
Ensembl chr 3:118,451,743...118,466,094
G
Mbp
myelin basic protein
increases expression
EXP
Ketamine results in increased expression of MBP mRNA
CTD
PMID:20080153
NCBI chr18:78,130,652...78,241,174
Ensembl chr18:75,855,878...75,966,404
G
Mcm3
minichromosome maintenance complex component 3
decreases expression
EXP
Ketamine results in decreased expression of MCM3 mRNA
CTD
PMID:20080153
NCBI chr 9:30,715,602...30,733,746
Ensembl chr 9:23,219,169...23,237,314
G
Mcu
mitochondrial calcium uniporter
decreases expression
EXP
Ketamine results in decreased expression of MCU mRNA
CTD
PMID:20080153
NCBI chr20:27,960,520...28,123,103
Ensembl chr20:27,417,526...27,580,110
G
Mettl16
methyltransferase 16, RNA N6-adenosine
decreases expression
EXP
Ketamine results in decreased expression of METTL16 mRNA
CTD
PMID:20080153
NCBI chr10:60,139,317...60,185,438
Ensembl chr10:59,640,972...59,687,061
G
Mettl25b
methyltransferase like 25B
increases expression
EXP
Ketamine results in increased expression of METTL25B mRNA
CTD
PMID:20080153
NCBI chr 2:175,686,483...175,695,137
Ensembl chr 2:173,388,625...173,397,279
G
Mettl3
methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
decreases expression
EXP
Ketamine results in decreased expression of METTL3 mRNA
CTD
PMID:20080153
NCBI chr15:27,476,659...27,491,134
Ensembl chr15:25,003,172...25,014,041
G
Mfsd2a
MFSD2 lysolipid transporter A, lysophospholipid
increases expression
EXP
Ketamine results in increased expression of MFSD2A mRNA
CTD
PMID:20080153
NCBI chr 5:140,510,933...140,525,828
Ensembl chr 5:135,225,816...135,240,690
G
Mgst2
microsomal glutathione S-transferase 2
increases expression
EXP
Ketamine results in increased expression of MGST2 mRNA
CTD
PMID:20080153
NCBI chr 2:137,821,787...137,866,664
Ensembl chr 2:135,693,557...135,715,828
G
Mgst3l1
microsomal glutathione S-transferase 3 like 1
increases expression
EXP
Ketamine results in increased expression of MGST3L1 mRNA
CTD
PMID:20080153
NCBI chr14:19,809,202...19,811,522
Ensembl chr14:19,525,558...19,526,016
G
Mib1
MIB E3 ubiquitin protein ligase 1
increases expression
EXP
Ketamine results in increased expression of MIB1 mRNA
CTD
PMID:20080153
NCBI chr18:2,075,309...2,199,774
Ensembl chr18:1,802,519...1,920,689
G
Mical1
microtubule associated monooxygenase, calponin and LIM domain containing 1
decreases expression
EXP
Ketamine results in decreased expression of MICAL1 mRNA
CTD
PMID:20080153
NCBI chr20:46,547,983...46,568,487
Ensembl chr20:44,974,138...44,986,089
G
Mif4gd
MIF4G domain containing
increases expression
EXP
Ketamine results in increased expression of MIF4GD mRNA
CTD
PMID:20080153
NCBI chr10:100,847,168...100,852,166
G
Mir22
microRNA 22
multiple interactions decreases expression
EXP
lipoxin A4 methyl ester inhibits the reaction [Ketamine results in decreased expression of MIR22 mRNA]; MIR22 affects the reaction [Ketamine results in increased expression of BAG5 mRNA]; MIR22 affects the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of BAG5 protein]]; MIR22 affects the reaction [lipoxin A4 methyl ester inhibits the reaction [Ketamine results in increased expression of CASP3 mRNA]]; MIR22 inhibits the reaction [Ketamine results in increased activity of CASP3 protein]; MIR22 inhibits the reaction [Ketamine results in increased activity of CASP9 protein]; MIR22 inhibits the reaction [Ketamine results in increased expression of BAG5 protein]
CTD
PMID:34670429
NCBI chr10:60,805,331...60,805,425
Ensembl chr10:60,307,039...60,307,133
G
Mis12
MIS12 kinetochore complex component
decreases expression
EXP
Ketamine results in decreased expression of MIS12 mRNA
CTD
PMID:20080153
NCBI chr10:55,739,741...55,747,915
Ensembl chr10:55,739,564...55,751,068
G
Mis18a
MIS18 kinetochore protein A
decreases expression
EXP
Ketamine results in decreased expression of MIS18A mRNA
CTD
PMID:20080153
NCBI chr11:43,454,129...43,467,157
Ensembl chr11:29,967,701...29,981,062
G
Mki67
marker of proliferation Ki-67
increases expression
ISO
Ketamine results in increased expression of MKI67 protein
CTD
PMID:19919587
NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
G
Mkks
MKKS centrosomal shuttling protein
decreases expression
EXP
Ketamine results in decreased expression of MKKS mRNA
CTD
PMID:20080153
NCBI chr 3:144,654,563...144,672,831
Ensembl chr 3:124,201,877...124,220,162
G
Mllt3
MLLT3, super elongation complex subunit
decreases expression
EXP
Ketamine results in decreased expression of MLLT3 mRNA
CTD
PMID:20080153
NCBI chr 5:107,305,008...107,561,352
Ensembl chr 5:102,260,011...102,515,361
G
Mmd2
monocyte to macrophage differentiation-associated 2
increases expression
EXP
Ketamine results in increased expression of MMD2 mRNA
CTD
PMID:20080153
NCBI chr12:17,075,870...17,123,255
Ensembl chr12:11,962,757...12,009,773
G
Mmp14
matrix metallopeptidase 14
decreases expression
EXP
Ketamine results in decreased expression of MMP14 mRNA
CTD
PMID:20080153
NCBI chr15:31,857,824...31,867,049
Ensembl chr15:27,887,727...27,899,864
G
Mog
myelin oligodendrocyte glycoprotein
increases expression
EXP
Ketamine results in increased expression of MOG mRNA
CTD
PMID:20080153
NCBI chr20:1,514,110...1,528,716
Ensembl chr20:1,513,239...1,523,474
G
Mon1a
MON1 homolog A, secretory trafficking associated
decreases expression
EXP
Ketamine results in decreased expression of MON1A mRNA
CTD
PMID:20080153
NCBI chr 8:117,452,868...117,471,780
Ensembl chr 8:108,574,388...108,593,156
G
Morn2
MORN repeat containing 2
increases expression
EXP
Ketamine results in increased expression of MORN2 mRNA
CTD
PMID:20080153
NCBI chr 6:20,471,036...20,477,520
G
Mras
muscle RAS oncogene homolog
increases expression
EXP
Ketamine results in increased expression of MRAS mRNA
CTD
PMID:20080153
NCBI chr 8:108,823,374...108,886,104
Ensembl chr 8:99,944,036...99,996,408
G
Mrpl18
mitochondrial ribosomal protein L18
decreases expression
EXP
Ketamine results in decreased expression of MRPL18 mRNA
CTD
PMID:20080153
NCBI chr 1:50,384,951...50,389,769
Ensembl chr 1:47,836,561...47,841,987
G
Mrpl50
mitochondrial ribosomal protein L50
decreases expression
EXP
Ketamine results in decreased expression of MRPL50 mRNA
CTD
PMID:20080153
NCBI chr 5:68,662,933...68,668,087
G
Mrps15
mitochondrial ribosomal protein S15
increases expression
EXP
Ketamine results in increased expression of MRPS15 mRNA
CTD
PMID:20080153
NCBI chr 5:138,321,610...138,332,205
Ensembl chr 5:138,321,593...138,332,205
G
Ms4a6a
membrane spanning 4-domains A6A
increases expression
EXP
Ketamine results in increased expression of MS4A6A mRNA
CTD
PMID:20080153
NCBI chr 1:217,826,261...217,839,606
Ensembl chr 1:208,401,466...208,414,758
G
Msantd3
Myb/SANT DNA binding domain containing 3
increases expression
EXP
Ketamine results in increased expression of MSANTD3 mRNA
CTD
PMID:20080153
NCBI chr 5:67,661,551...67,687,971
Ensembl chr 5:62,866,022...62,888,859
G
Msmo1
methylsterol monooxygenase 1
decreases expression
EXP
Ketamine results in decreased expression of MSMO1 mRNA
CTD
PMID:20080153
NCBI chr16:29,747,113...29,764,360
Ensembl chr16:24,980,697...24,998,016
G
Mt1
metallothionein 1
increases expression
EXP
Ketamine results in increased expression of MT1A mRNA
CTD
PMID:20080153
NCBI chr19:10,831,959...10,832,975
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
G
Mtcl3
MTCL family member 3
decreases expression
EXP
Ketamine results in decreased expression of MTCL3 mRNA
CTD
PMID:20080153
NCBI chr 1:30,469,698...30,530,205
Ensembl chr 1:28,620,293...28,701,796
G
Mterf2
mitochondrial transcription termination factor 2
decreases expression
EXP
Ketamine results in decreased expression of MTERF2 mRNA
CTD
PMID:20080153
NCBI chr 7:20,485,901...20,495,979
Ensembl chr 7:18,598,103...18,620,684
G
Mtg2
mitochondrial ribosome-associated GTPase 2
decreases expression
EXP
Ketamine results in decreased expression of MTG2 mRNA
CTD
PMID:20080153
NCBI chr 3:167,165,542...167,181,358
Ensembl chr 3:167,165,982...167,181,358
G
Myc
MYC proto-oncogene, bHLH transcription factor
decreases expression
EXP
Ketamine results in decreased expression of MYC mRNA
CTD
PMID:20080153
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
G
Mycn
MYCN proto-oncogene, bHLH transcription factor
decreases expression
EXP
Ketamine results in decreased expression of MYCN mRNA
CTD
PMID:20080153
NCBI chr 6:41,446,683...41,452,584
Ensembl chr 6:35,717,764...35,723,590
G
Myo19
myosin XIX
decreases expression
EXP
Ketamine results in decreased expression of MYO19 mRNA
CTD
PMID:20080153
NCBI chr10:70,250,500...70,279,867
Ensembl chr10:69,753,068...69,782,450
G
Naa35
N(alpha)-acetyltransferase 35, NatC auxiliary subunit
decreases expression
EXP
Ketamine results in decreased expression of NAA35 mRNA
CTD
PMID:20080153
NCBI chr17:5,034,360...5,086,456
Ensembl chr17:5,034,356...5,086,386
G
Nab1
Ngfi-A binding protein 1
decreases expression
EXP
Ketamine results in decreased expression of NAB1 mRNA
CTD
PMID:20080153
NCBI chr 9:56,545,547...56,585,045
Ensembl chr 9:49,053,758...49,092,098
G
Nabp1
nucleic acid binding protein 1
decreases expression
EXP
Ketamine results in decreased expression of NABP1 mRNA
CTD
PMID:20080153
NCBI chr 9:57,570,326...57,625,926
Ensembl chr 9:50,126,726...50,134,107
G
Nav3
neuron navigator 3
decreases expression
EXP
Ketamine results in decreased expression of NAV3 mRNA
CTD
PMID:20080153
NCBI chr 7:46,938,577...47,726,839
Ensembl chr 7:45,054,296...45,840,698
G
Ncdn
neurochondrin
increases expression
EXP
Ketamine results in increased expression of NCDN mRNA
CTD
PMID:20080153
NCBI chr 5:144,322,287...144,332,117
Ensembl chr 5:139,037,819...139,047,568
G
Nckap1l
NCK associated protein 1 like
multiple interactions decreases expression
EXP
Cannabidiol inhibits the reaction [Ketamine results in decreased expression of NCKAP1L mRNA]
CTD
PMID:31823199
NCBI chr 7:136,455,900...136,501,384
Ensembl chr 7:134,577,482...134,622,934
G
Ndrg2
NDRG family member 2
increases expression
EXP
Ketamine results in increased expression of NDRG2 mRNA
CTD
PMID:20080153
NCBI chr15:27,074,481...27,087,376
Ensembl chr15:24,600,982...24,609,626
G
Ndufs1
NADH:ubiquinone oxidoreductase core subunit S1
decreases expression
EXP
Ketamine results in decreased expression of NDUFS1 protein
CTD
PMID:18504422
NCBI chr 9:72,040,286...72,073,605
Ensembl chr 9:64,546,225...64,579,893
G
Nectin3
nectin cell adhesion molecule 3
decreases expression
EXP
Ketamine results in decreased expression of NECTIN3 mRNA
CTD
PMID:20080153
NCBI chr11:67,825,296...67,931,999
Ensembl chr11:54,364,487...54,462,519
G
Nefh
neurofilament heavy chain
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of NEFH mRNA
CTD
PMID:16635253
NCBI chr14:84,044,428...84,054,413
Ensembl chr14:79,830,362...79,840,351
G
Nefl
neurofilament light chain
decreases expression increases expression
EXP
Ketamine results in decreased expression of NEFL protein Ketamine results in increased expression of NEFL mRNA
CTD
PMID:18504422 PMID:20080153
NCBI chr15:46,477,330...46,481,203
Ensembl chr15:42,301,916...42,305,793
G
Nes
nestin
decreases expression
EXP
Ketamine results in decreased expression of NES mRNA
CTD
PMID:20080153
NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:173,438,734...173,447,777
G
Neurod1
neuronal differentiation 1
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of NEUROD1 mRNA
CTD
PMID:16635253
NCBI chr 3:84,766,483...84,770,454
Ensembl chr 3:64,359,395...64,363,649
G
Neurod6
neuronal differentiation 6
decreases expression
EXP
Ketamine results in decreased expression of NEUROD6 mRNA
CTD
PMID:20080153
NCBI chr 4:86,176,909...86,180,155
Ensembl chr 4:84,846,231...84,849,999
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions decreases expression
EXP
Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 protein modified form]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NFE2L2 protein] Ketamine results in decreased expression of NFE2L2 mRNA; Ketamine results in decreased expression of NFE2L2 protein; Ketamine results in decreased expression of NFE2L2 protein modified form
CTD
PMID:36305173
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
G
Nfe2l3
NFE2 like bZIP transcription factor 3
decreases expression
EXP
Ketamine results in decreased expression of NFE2L3 mRNA
CTD
PMID:20080153
NCBI chr 4:81,837,404...81,865,258
Ensembl chr 4:80,506,756...80,534,629
G
Nfil3
nuclear factor, interleukin 3 regulated
decreases expression
EXP
Ketamine results in decreased expression of NFIL3 mRNA
CTD
PMID:20080153
NCBI chr17:12,432,376...12,447,605
Ensembl chr17:12,280,484...12,295,858
G
Nfkbia
NFKB inhibitor alpha
increases expression multiple interactions increases phosphorylation
EXP
Ketamine results in increased expression of NFKBIA mRNA TRPV4 protein affects the reaction [Ketamine results in increased phosphorylation of NFKBIA protein]
CTD
PMID:20080153 PMID:33536391
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
G
Ngf
nerve growth factor
multiple interactions
EXP
Ketamine inhibits the reaction [Pilocarpine results in increased expression of NGF mRNA]
CTD
PMID:8635431
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452
G
Nif3l1
NGG1 interacting factor 3 like 1
decreases expression
EXP
Ketamine results in decreased expression of NIF3L1 mRNA
CTD
PMID:20080153
NCBI chr 9:67,474,286...67,494,350
Ensembl chr 9:59,979,799...60,000,131
G
Nkiras1
NFKB inhibitor interacting Ras-like 1
increases expression
EXP
Ketamine results in increased expression of NKIRAS1 mRNA
CTD
PMID:20080153
NCBI chr15:9,924,316...9,934,538
Ensembl chr15:7,493,531...7,503,854
G
Nkx6-2
NK6 homeobox 2
increases expression
EXP
Ketamine results in increased expression of NKX6-2 mRNA
CTD
PMID:20080153
NCBI chr 1:203,811,582...203,813,122
Ensembl chr 1:194,381,975...194,383,515
G
Nln
neurolysin
decreases expression
EXP
Ketamine results in decreased expression of NLN mRNA
CTD
PMID:20080153
NCBI chr 2:36,867,436...36,966,749
Ensembl chr 2:35,134,145...35,232,914
G
Nmb
neuromedin B
increases expression
EXP
Ketamine results in increased expression of NMB mRNA
CTD
PMID:20080153
NCBI chr 1:144,278,678...144,290,523
Ensembl chr 1:134,869,446...134,872,190
G
Nme6
NME/NM23 nucleoside diphosphate kinase 6
decreases expression
EXP
Ketamine results in decreased expression of NME6 mRNA
CTD
PMID:20080153
NCBI chr 8:118,708,092...118,717,756
Ensembl chr 8:109,832,589...109,839,301
G
Nnt
nicotinamide nucleotide transhydrogenase
decreases expression
EXP
Ketamine results in decreased expression of NNT mRNA
CTD
PMID:20080153
NCBI chr 2:53,144,157...53,237,857
Ensembl chr 2:51,411,413...51,504,823
G
Nol4
nucleolar protein 4
decreases expression
EXP
Ketamine results in decreased expression of NOL4 mRNA
CTD
PMID:20080153
NCBI chr18:14,207,303...14,569,697
Ensembl chr18:13,932,510...14,296,286
G
Nova2
NOVA alternative splicing regulator 2
decreases expression
EXP
Ketamine results in decreased expression of NOVA2 mRNA
CTD
PMID:20080153
NCBI chr 1:87,700,328...87,741,755
Ensembl chr 1:78,572,279...78,608,021
G
Npm3
nucleophosmin/nucleoplasmin, 3
decreases expression
EXP
Ketamine results in decreased expression of NPM3 mRNA
CTD
PMID:20080153
NCBI chr 1:244,595,638...244,597,623
Ensembl chr 1:244,595,644...244,597,591
G
Nppc
natriuretic peptide C
decreases expression
EXP
Ketamine results in decreased expression of NPPC mRNA
CTD
PMID:20080153
NCBI chr 9:94,767,986...94,772,186
Ensembl chr 9:87,320,051...87,324,251
G
Npy
neuropeptide Y
increases response to substance
ISO
NPY protein results in increased susceptibility to Ketamine
CTD
PMID:11454027
NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:78,881,264...78,888,495
G
Npy1r
neuropeptide Y receptor Y1
decreases expression
EXP
Ketamine results in decreased expression of NPY1R mRNA
CTD
PMID:20080153
NCBI chr16:27,804,416...27,814,070
Ensembl chr16:23,037,789...23,046,759
G
Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions decreases expression
EXP
Curcumin inhibits the reaction [Ketamine results in decreased expression of NQO1 mRNA]; Curcumin inhibits the reaction [Ketamine results in decreased expression of NQO1 protein] Ketamine results in decreased expression of NQO1 mRNA; Ketamine results in decreased expression of NQO1 protein
CTD
PMID:36305173
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
G
Nr1d1
nuclear receptor subfamily 1, group D, member 1
increases expression
EXP
Ketamine results in increased expression of NR1D1 mRNA
CTD
PMID:20080153
NCBI chr10:84,224,599...84,231,812
Ensembl chr10:83,728,318...83,735,705
G
Nr4a2
nuclear receptor subfamily 4, group A, member 2
decreases expression
EXP
Ketamine results in decreased expression of NR4A2 mRNA
CTD
PMID:20080153
NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:41,689,851...41,697,877
G
Nr4a3
nuclear receptor subfamily 4, group A, member 3
decreases expression
EXP
Ketamine results in decreased expression of NR4A3 mRNA
CTD
PMID:20080153
NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:62,361,822...62,402,733
G
Nradd
neurotrophin receptor associated death domain
decreases expression
EXP
Ketamine results in decreased expression of NRADD mRNA
CTD
PMID:20080153
NCBI chr 8:119,478,055...119,481,336
Ensembl chr 8:110,599,667...110,603,149
G
Nrde2
NRDE-2, necessary for RNA interference, domain containing
increases expression
EXP
Ketamine results in increased expression of NRDE2 mRNA
CTD
PMID:20080153
NCBI chr 6:125,137,121...125,177,689
Ensembl chr 6:119,404,334...119,448,915
G
Nrep
neuronal regeneration related protein
decreases expression multiple interactions
EXP
Ketamine results in decreased expression of NREP mRNA [ampullosporin co-treated with Ketamine] results in increased expression of NREP mRNA
CTD
PMID:16635253 PMID:20080153
NCBI chr18:25,291,219...25,320,742
Ensembl chr18:25,017,083...25,046,591
G
Nrg1
neuregulin 1
decreases expression
ISO
Ketamine results in decreased expression of NRG1 mRNA
CTD
PMID:20000043
NCBI chr16:65,954,084...67,007,484
Ensembl chr16:59,250,854...60,296,884
G
Nrgn
neurogranin
increases expression
EXP
Ketamine results in increased expression of NRGN mRNA
CTD
PMID:20080153
NCBI chr 8:45,444,223...45,452,417
Ensembl chr 8:37,256,930...37,257,516
G
Nrip3
nuclear receptor interacting protein 3
decreases expression
EXP
Ketamine results in decreased expression of NRIP3 mRNA
CTD
PMID:20080153
NCBI chr 1:173,224,532...173,249,829
Ensembl chr 1:163,789,738...163,815,600
G
Nsf
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
increases expression
EXP
Ketamine results in increased expression of NSF mRNA
CTD
PMID:20080153
NCBI chr10:89,227,937...89,357,383
Ensembl chr10:88,727,912...88,857,386
G
Nsmce2
NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase
decreases expression
EXP
Ketamine results in decreased expression of NSMCE2 mRNA
CTD
PMID:20080153
NCBI chr 7:92,825,568...93,071,037
Ensembl chr 7:90,936,112...91,164,899
G
Nsmf
NMDA receptor synaptonuclear signaling and neuronal migration factor
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of NSMF mRNA
CTD
PMID:16635253
NCBI chr 3:28,260,018...28,268,790
Ensembl chr 3:7,861,872...7,870,614
G
Nt5c2
5'-nucleotidase, cytosolic II
increases expression
EXP
Ketamine results in increased expression of NT5C2 mRNA
CTD
PMID:20080153
NCBI chr 1:255,712,797...255,838,285
Ensembl chr 1:245,772,277...245,897,913
G
Ntf3
neurotrophin 3
decreases expression
EXP
Ketamine results in decreased expression of NTF3 mRNA
CTD
PMID:20080153
NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:158,914,957...158,984,596
G
Ntrk1
neurotrophic receptor tyrosine kinase 1
increases expression
EXP
Ketamine results in increased expression of NTRK1 mRNA
CTD
PMID:20080153
NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:173,236,963...173,253,770
G
Ntrk2
neurotrophic receptor tyrosine kinase 2
multiple interactions
EXP ISO
Ketamine inhibits the reaction [Pilocarpine results in increased expression of NTRK2 mRNA] Ketamine inhibits the reaction [NTRK2 protein binds to AP2M1 protein]
CTD
PMID:8635431 PMID:31631060
NCBI chr17:5,560,558...5,875,899
Ensembl chr17:5,559,043...5,869,136
G
Nudt6
nudix hydrolase 6
increases expression
EXP
Ketamine results in increased expression of NUDT6 mRNA
CTD
PMID:20080153
NCBI chr 2:120,289,908...120,306,197
Ensembl chr 2:120,290,847...120,306,230
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Nup205
nucleoporin 205
decreases expression
EXP
Ketamine results in decreased expression of NUP205 mRNA
CTD
PMID:20080153
NCBI chr 4:64,822,051...64,887,996
Ensembl chr 4:63,854,783...63,920,844
G
Nup35
nucleoporin 35
decreases expression
EXP
Ketamine results in decreased expression of NUP35 mRNA
CTD
PMID:20080153
NCBI chr 3:85,965,907...85,991,659
Ensembl chr 3:65,558,968...65,585,130
G
Nup42
nucleoporin 42
increases expression
EXP
Ketamine results in increased expression of NUP42 mRNA
CTD
PMID:20080153
NCBI chr 4:10,985,554...11,002,591
Ensembl chr 4:10,985,554...11,002,591
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Nup58
nucleoporin 58
decreases expression
EXP
Ketamine results in decreased expression of NUP58 mRNA
CTD
PMID:20080153
NCBI chr15:38,534,340...38,583,959
Ensembl chr15:34,358,277...34,407,060
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Nusap1
nucleolar and spindle associated protein 1
decreases expression
EXP
Ketamine results in decreased expression of NUSAP1 mRNA
CTD
PMID:20080153
NCBI chr 3:127,057,220...127,092,779
Ensembl chr 3:106,603,289...106,633,624
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Ocln
occludin
multiple interactions
ISO
Ketamine inhibits the reaction [KNG1 protein results in increased expression of OCLN protein]
CTD
PMID:27638051
NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150
G
Oplah
5-oxoprolinase (ATP-hydrolysing)
increases expression
EXP
Ketamine results in increased expression of OPLAH mRNA
CTD
PMID:20080153
NCBI chr 7:109,892,136...109,932,403
Ensembl chr 7:108,011,475...108,035,297
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Orc4
origin recognition complex, subunit 4
increases expression
EXP
Ketamine results in increased expression of ORC4 mRNA
CTD
PMID:20080153
NCBI chr 3:33,290,844...33,334,022
Ensembl chr 3:33,294,355...33,333,824
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Ormdl3
ORMDL sphingolipid biosynthesis regulator 3
increases expression
EXP
Ketamine results in increased expression of ORMDL3 mRNA
CTD
PMID:20080153
NCBI chr10:84,086,317...84,092,673
Ensembl chr10:83,590,071...83,598,620
G
Oxsr1
oxidative stress responsive kinase 1
decreases expression
EXP
Ketamine results in decreased expression of OXSR1 mRNA
CTD
PMID:20080153
NCBI chr 8:127,850,481...127,941,518
Ensembl chr 8:118,972,754...119,062,027
G
P2rx6
purinergic receptor P2X 6
increases expression
EXP
Ketamine results in increased expression of P2RX6 mRNA
CTD
PMID:20080153
NCBI chr11:96,944,167...96,956,424
Ensembl chr11:83,439,924...83,450,481
G
P4ha1
prolyl 4-hydroxylase subunit alpha 1
decreases expression
EXP
Ketamine results in decreased expression of P4HA1 mRNA
CTD
PMID:20080153
NCBI chr20:27,784,696...27,895,785
Ensembl chr20:27,302,141...27,352,786
G
P4htm
prolyl 4-hydroxylase, transmembrane
increases expression
EXP
Ketamine results in increased expression of P4HTM mRNA
CTD
PMID:20080153
NCBI chr 8:118,153,158...118,172,199
Ensembl chr 8:109,274,626...109,292,473
G
Pak5
p21 (RAC1) activated kinase 5
decreases expression
EXP
Ketamine results in decreased expression of PAK5 mRNA
CTD
PMID:20080153
NCBI chr 3:143,848,404...144,156,674
Ensembl chr 3:123,396,497...123,703,930
G
Pank1
pantothenate kinase 1
decreases expression
EXP
Ketamine results in decreased expression of PANK1 mRNA
CTD
PMID:20080153
NCBI chr 1:241,737,371...241,808,126
Ensembl chr 1:232,328,430...232,396,829
G
Papola
poly (A) polymerase alpha
decreases expression
EXP
Ketamine results in decreased expression of PAPOLA mRNA
CTD
PMID:20080153
NCBI chr 6:130,446,236...130,499,371
Ensembl chr 6:124,682,105...124,734,468
G
Pard6g
par-6 family cell polarity regulator gamma
decreases expression
EXP
Ketamine results in decreased expression of PARD6G mRNA
CTD
PMID:20080153
NCBI chr18:75,772,992...75,840,041
Ensembl chr18:73,498,021...73,565,029
G
Patj
PATJ, crumbs cell polarity complex component
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of PATJ mRNA
CTD
PMID:16635253
NCBI chr 5:118,177,557...118,480,301
Ensembl chr 5:113,062,118...113,364,807
G
Pbk
PDZ binding kinase
decreases expression
EXP
Ketamine results in decreased expression of PBK mRNA
CTD
PMID:20080153
NCBI chr15:44,198,506...44,209,572
Ensembl chr15:40,023,002...40,034,014
G
Pbx3
PBX homeobox 3
decreases expression
EXP
Ketamine results in decreased expression of PBX3 mRNA
CTD
PMID:20080153
NCBI chr 3:37,886,241...38,079,956
Ensembl chr 3:17,488,693...17,682,791
G
Pcgf6
polycomb group ring finger 6
decreases expression
EXP
Ketamine results in decreased expression of PCGF6 mRNA
CTD
PMID:20080153
NCBI chr 1:255,866,709...255,886,306
Ensembl chr 1:245,925,360...245,944,914
G
Pclaf
PCNA clamp associated factor
decreases expression
EXP
Ketamine results in decreased expression of PCLAF mRNA
CTD
PMID:20080153
NCBI chr 8:75,311,028...75,328,108
Ensembl chr 8:66,420,587...66,432,994 Ensembl chr 8:66,420,587...66,432,994
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Pcsk2
proprotein convertase subtilisin/kexin type 2
increases expression
EXP
Ketamine results in increased expression of PCSK2 mRNA
CTD
PMID:20080153
NCBI chr 3:151,333,938...151,636,628
Ensembl chr 3:130,880,422...131,183,127
G
Pcsk6
proprotein convertase subtilisin/kexin type 6
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of PCSK6 mRNA
CTD
PMID:16635253
NCBI chr 1:128,839,742...129,038,087
Ensembl chr 1:119,429,265...119,627,596
G
Pde12
phosphodiesterase 12
increases expression
EXP
Ketamine results in increased expression of PDE12 mRNA
CTD
PMID:20080153
NCBI chr16:1,926,807...1,932,383
Ensembl chr16:1,915,386...1,925,887
G
Pde2a
phosphodiesterase 2A
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of PDE2A mRNA
CTD
PMID:16635253
NCBI chr 1:165,235,623...165,327,466
Ensembl chr 1:155,813,180...155,915,434
G
Pdia2
protein disulfide isomerase family A, member 2
decreases expression
EXP
Ketamine results in decreased expression of PDIA2 mRNA
CTD
PMID:20080153
NCBI chr10:15,720,301...15,723,386
Ensembl chr10:15,215,824...15,220,931
G
Pdia4
protein disulfide isomerase family A, member 4
decreases expression
EXP
Ketamine results in decreased expression of PDIA4 mRNA
CTD
PMID:20080153
NCBI chr 4:78,134,144...78,153,191
Ensembl chr 4:76,803,198...76,822,107
G
Pdia5
protein disulfide isomerase family A, member 5
decreases expression
EXP
Ketamine results in decreased expression of PDIA5 mRNA
CTD
PMID:20080153
NCBI chr11:78,777,436...78,892,370
Ensembl chr11:65,272,155...65,359,084
G
Pdia6
protein disulfide isomerase family A, member 6
decreases expression
EXP
Ketamine results in decreased expression of PDIA6 mRNA
CTD
PMID:20080153
NCBI chr 6:45,791,704...45,808,947
Ensembl chr 6:40,062,926...40,080,613
G
Pdik1l
PDLIM1 interacting kinase 1 like
decreases expression
EXP
Ketamine results in decreased expression of PDIK1L mRNA
CTD
PMID:20080153
NCBI chr 5:151,778,813...151,793,137
Ensembl chr 5:146,495,115...146,506,835
G
Pdk2
pyruvate dehydrogenase kinase 2
increases expression
EXP
Ketamine results in increased expression of PDK2 mRNA
CTD
PMID:20080153
NCBI chr10:80,469,388...80,483,988
Ensembl chr10:79,972,556...79,987,085
G
Pdlim7
PDZ and LIM domain 7
decreases expression
EXP
Ketamine results in decreased expression of PDLIM7 mRNA
CTD
PMID:20080153
NCBI chr17:9,129,603...9,144,956
Ensembl chr17:9,124,649...9,139,811
G
Pdp2
pyruvate dehydrogenase phosphatase catalytic subunit 2
decreases expression
EXP
Ketamine results in decreased expression of PDP2 mRNA
CTD
PMID:20080153
NCBI chr19:392,858...400,529
Ensembl chr19:386,406...394,074
G
Pdrg1
p53 and DNA damage regulated 1
increases expression
EXP
Ketamine results in increased expression of PDRG1 mRNA
CTD
PMID:20080153
NCBI chr 3:161,937,812...161,943,981
Ensembl chr 3:141,476,501...141,483,858 Ensembl chr 3:141,476,501...141,483,858
G
Pef1
penta-EF hand domain containing 1
increases expression
EXP
Ketamine results in increased expression of PEF1 mRNA
CTD
PMID:20080153
NCBI chr 5:142,451,791...142,475,061
Ensembl chr 5:142,451,778...142,475,067
G
Per1
period circadian regulator 1
increases expression
EXP
Ketamine results in increased expression of PER1 mRNA
CTD
PMID:20080153
NCBI chr10:54,299,002...54,313,804
Ensembl chr10:53,805,535...53,814,431
G
Per2
period circadian regulator 2
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of PER2 mRNA
CTD
PMID:16635253
NCBI chr 9:99,454,828...99,497,069
Ensembl chr 9:92,007,296...92,049,459
G
Pex6
peroxisomal biogenesis factor 6
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of PEX6 mRNA
CTD
PMID:16635253
NCBI chr 9:21,755,747...21,767,939
Ensembl chr 9:14,258,145...14,270,303
G
Pgpep1
pyroglutamyl-peptidase I
decreases expression
EXP
Ketamine results in decreased expression of PGPEP1 mRNA
CTD
PMID:20080153
NCBI chr16:18,804,408...18,817,466
Ensembl chr16:18,771,021...18,783,478
G
Phactr3
phosphatase and actin regulator 3
decreases expression
EXP
Ketamine results in decreased expression of PHACTR3 mRNA
CTD
PMID:20080153
NCBI chr 3:185,582,134...185,801,404
Ensembl chr 3:165,205,255...165,423,153
G
Phb1
prohibitin 1
increases expression
EXP
Ketamine results in increased expression of PHB1 protein
CTD
PMID:18504422
NCBI chr10:81,102,043...81,114,815
Ensembl chr10:80,605,251...80,618,042
G
Phf13
PHD finger protein 13
decreases expression
EXP
Ketamine results in decreased expression of PHF13 mRNA
CTD
PMID:20080153
NCBI chr 5:162,494,574...162,501,350
Ensembl chr 5:162,494,573...162,501,350
G
Phf14
PHD finger protein 14
decreases expression
EXP
Ketamine results in decreased expression of PHF14 mRNA
CTD
PMID:20080153
NCBI chr 4:40,975,897...41,162,043
Ensembl chr 4:40,009,264...40,195,885
G
Phrf1
PHD and ring finger domains 1
decreases expression
EXP
Ketamine results in decreased expression of PHRF1 mRNA
CTD
PMID:20080153
NCBI chr 1:205,763,264...205,796,478
Ensembl chr 1:196,333,903...196,366,892
G
Phyhip
phytanoyl-CoA 2-hydroxylase interacting protein
increases expression
EXP
Ketamine results in increased expression of PHYHIP mRNA
CTD
PMID:20080153
NCBI chr15:45,533,974...45,545,223
Ensembl chr15:45,533,974...45,545,221
G
Pibf1
progesterone immunomodulatory binding factor 1
decreases expression
EXP
Ketamine results in decreased expression of PIBF1 mRNA
CTD
PMID:20080153
NCBI chr15:82,258,243...82,427,546
Ensembl chr15:75,850,624...76,019,712
G
Pigl
phosphatidylinositol glycan anchor biosynthesis, class L
decreases expression
EXP
Ketamine results in decreased expression of PIGL mRNA
CTD
PMID:20080153
NCBI chr10:47,641,478...47,699,200
Ensembl chr10:47,141,780...47,200,145
G
Pik3ap1
phosphoinositide-3-kinase adaptor protein 1
decreases expression
EXP
Ketamine results in decreased expression of PIK3AP1 mRNA
CTD
PMID:20080153
NCBI chr 1:250,040,250...250,194,364
Ensembl chr 1:240,093,065...240,204,828
G
Pik3ip1
phosphoinositide-3-kinase interacting protein 1
increases expression
EXP
Ketamine results in increased expression of PIK3IP1 mRNA
CTD
PMID:20080153
NCBI chr14:82,428,315...82,440,261
Ensembl chr14:78,204,053...78,216,608
G
Pip4k2a
phosphatidylinositol-5-phosphate 4-kinase type 2 alpha
decreases expression
EXP
Ketamine results in decreased expression of PIP4K2A mRNA
CTD
PMID:20080153
NCBI chr17:86,405,080...86,576,597
Ensembl chr17:81,496,670...81,668,029
G
Pkd1
polycystin 1, transient receptor potential channel interacting
increases expression
EXP
Ketamine results in increased expression of PKD1 mRNA
CTD
PMID:20080153
NCBI chr10:14,077,733...14,125,682
Ensembl chr10:13,573,021...13,621,128
G
Plaat3
phospholipase A and acyltransferase 3
increases expression
EXP
Ketamine results in increased expression of PLAAT3 mRNA
CTD
PMID:20080153
NCBI chr 1:214,211,755...214,245,551
Ensembl chr 1:204,782,729...204,817,667
G
Plat
plasminogen activator, tissue type
increases expression
EXP
Ketamine results in increased expression of PLAT mRNA
CTD
PMID:20080153
NCBI chr16:75,943,061...76,022,037
Ensembl chr16:69,240,585...69,268,223
G
Plcd4
phospholipase C, delta 4
increases expression
EXP
Ketamine results in increased expression of PLCD4 mRNA
CTD
PMID:20080153
NCBI chr 9:83,564,616...83,613,742
Ensembl chr 9:76,117,168...76,142,453
G
Plcl1
phospholipase C-like 1
decreases expression
EXP
Ketamine results in decreased expression of PLCL1 mRNA
CTD
PMID:20080153
NCBI chr 9:64,395,976...64,733,171
Ensembl chr 9:56,901,534...57,238,782
G
Plcxd3
phosphatidylinositol-specific phospholipase C, X domain containing 3
decreases expression
EXP
Ketamine results in decreased expression of PLCXD3 mRNA
CTD
PMID:20080153
NCBI chr 2:55,294,597...55,473,968
Ensembl chr 2:53,567,022...53,746,384
G
Pld4
phospholipase D family, member 4
increases expression
EXP
Ketamine results in increased expression of PLD4 mRNA
CTD
PMID:20080153
NCBI chr 6:137,639,948...137,647,462
Ensembl chr 6:131,818,860...131,826,376
G
Plekhb1
pleckstrin homology domain containing B1
increases expression
EXP
Ketamine results in increased expression of PLEKHB1 mRNA
CTD
PMID:20080153
NCBI chr 1:154,998,798...155,013,094
Ensembl chr 1:154,998,800...155,016,142
G
Plekhf2
pleckstrin homology and FYVE domain containing 2
decreases expression
EXP
Ketamine results in decreased expression of PLEKHF2 mRNA
CTD
PMID:20080153
NCBI chr 5:28,888,358...28,905,350
Ensembl chr 5:24,090,688...24,106,601
G
Plgrkt
plasminogen receptor with a C-terminal lysine
decreases expression
EXP
Ketamine results in decreased expression of PLGRKT mRNA
CTD
PMID:20080153
NCBI chr 1:236,512,574...236,526,858
Ensembl chr 1:227,099,015...227,111,194
G
Plp1
proteolipid protein 1
increases expression
EXP
Ketamine results in increased expression of PLP1 mRNA
CTD
PMID:20080153
NCBI chr X:104,933,921...104,993,317
Ensembl chr X:100,185,767...100,201,032
G
Plppr1
phospholipid phosphatase related 1
decreases expression
EXP
Ketamine results in decreased expression of PLPPR1 mRNA
CTD
PMID:20080153
NCBI chr 5:68,232,963...68,520,784
Ensembl chr 5:63,437,816...63,763,835
G
Plvap
plasmalemma vesicle associated protein
increases expression
EXP
Ketamine results in increased expression of PLVAP mRNA
CTD
PMID:20080153
NCBI chr16:18,218,966...18,231,279
Ensembl chr16:18,184,975...18,197,301
G
Plxna2
plexin A2
decreases expression
EXP
Ketamine results in decreased expression of PLXNA2 mRNA
CTD
PMID:20080153
NCBI chr13:108,683,155...108,888,336
Ensembl chr13:106,163,103...106,358,979
G
Pmpca
peptidase, mitochondrial processing subunit alpha
increases expression
EXP
Ketamine results in increased expression of PMPCA mRNA
CTD
PMID:20080153
NCBI chr 3:29,605,823...29,614,936
Ensembl chr 3:9,207,717...9,216,844
G
Pnp
purine nucleoside phosphorylase
decreases expression
EXP
Ketamine results in decreased expression of PNP mRNA
CTD
PMID:20080153
NCBI chr15:26,644,147...26,651,808
Ensembl chr15:24,170,602...24,203,986
G
Pnpla2
patatin-like phospholipase domain containing 2
increases expression
EXP
Ketamine results in increased expression of PNPLA2 mRNA
CTD
PMID:20080153
NCBI chr 1:205,982,279...205,987,361
Ensembl chr 1:196,552,723...196,557,805
G
Pofut2
protein O-fucosyltransferase 2
decreases expression
EXP
Ketamine results in decreased expression of POFUT2 mRNA
CTD
PMID:20080153
NCBI chr20:11,366,636...11,378,252
Ensembl chr20:11,367,096...11,377,743
G
Pola1
DNA polymerase alpha 1, catalytic subunit
decreases expression
EXP
Ketamine results in decreased expression of POLA1 mRNA
CTD
PMID:20080153
NCBI chr X:62,028,475...62,342,455
Ensembl chr X:58,034,619...58,348,536
G
Pold1
DNA polymerase delta 1, catalytic subunit
decreases expression
EXP
Ketamine results in decreased expression of POLD1 mRNA
CTD
PMID:20080153
NCBI chr 1:104,161,984...104,178,074
Ensembl chr 1:95,025,499...95,036,465
G
Pole2
DNA polymerase epsilon 2, accessory subunit
decreases expression
EXP
Ketamine results in decreased expression of POLE2 mRNA
CTD
PMID:20080153
NCBI chr 6:93,410,713...93,448,782
Ensembl chr 6:87,674,702...87,699,305
G
Polg
DNA polymerase gamma, catalytic subunit
decreases expression
EXP
Ketamine results in decreased expression of POLG mRNA
CTD
PMID:20080153
NCBI chr 1:142,792,119...142,808,933
Ensembl chr 1:133,382,766...133,398,567
G
Polr2f
RNA polymerase II, I and III subunit F
increases expression
EXP
Ketamine results in increased expression of POLR2F mRNA
CTD
PMID:20080153
NCBI chr 7:112,592,977...112,604,681
Ensembl chr 7:110,712,572...110,724,234
G
Polr3f
RNA polymerase III subunit F
increases expression
EXP
Ketamine results in increased expression of POLR3F mRNA
CTD
PMID:20080153
NCBI chr 3:152,361,798...152,378,169
Ensembl chr 3:131,908,466...131,924,837
G
Polr3h
RNA polymerase III subunit H
decreases expression
EXP
Ketamine results in decreased expression of POLR3H mRNA
CTD
PMID:20080153
NCBI chr 7:115,309,571...115,319,881
Ensembl chr 7:113,429,451...113,439,778
G
Pomt2
protein-O-mannosyltransferase 2
decreases expression
EXP
Ketamine results in decreased expression of POMT2 mRNA
CTD
PMID:20080153
NCBI chr 6:112,486,416...112,525,799
Ensembl chr 6:106,755,462...106,794,849
G
Potem
POTE ankyrin domain family member M
increases expression
EXP
Ketamine results in increased expression of POTEM mRNA
CTD
PMID:20080153
NCBI chr16:20,193,646...20,311,924
Ensembl chr16:19,949,230...19,976,541
G
Pou3f2
POU class 3 homeobox 2
decreases expression
EXP
Ketamine results in decreased expression of POU3F2 mRNA
CTD
PMID:20080153
NCBI chr 5:40,874,631...40,880,539
Ensembl chr 5:36,077,930...36,083,838
G
Ppm1d
protein phosphatase, Mg2+/Mn2+ dependent, 1D
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of PPM1D mRNA
CTD
PMID:16635253
NCBI chr10:70,670,026...70,706,030
Ensembl chr10:70,172,603...70,208,607
G
Ppp1r14b
protein phosphatase 1, regulatory (inhibitor) subunit 14B
decreases expression
EXP
Ketamine results in decreased expression of PPP1R14B mRNA
CTD
PMID:20080153
NCBI chr 1:213,594,416...213,596,527
Ensembl chr 1:204,163,299...204,167,319 Ensembl chr12:204,163,299...204,167,319
G
Ppp1r18
protein phosphatase 1, regulatory subunit 18
decreases expression
EXP
Ketamine results in decreased expression of PPP1R18 mRNA
CTD
PMID:20080153
NCBI chr20:2,882,370...2,892,329
Ensembl chr20:2,877,567...2,891,802
G
Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
increases expression
EXP
Ketamine results in increased expression of PPP1R1B mRNA
CTD
PMID:20080153
NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,347,731...83,356,775
G
Pprc1
PPARG related coactivator 1
decreases expression
EXP
Ketamine results in decreased expression of PPRC1 mRNA
CTD
PMID:20080153
NCBI chr 1:254,851,136...254,867,570
Ensembl chr 1:244,902,179...244,918,587
G
Prkag2
protein kinase AMP-activated non-catalytic subunit gamma 2
decreases expression
EXP
Ketamine results in decreased expression of PRKAG2 mRNA
CTD
PMID:20080153
NCBI chr 4:10,744,695...10,985,939
Ensembl chr 4:10,010,890...10,252,142
G
Prkcg
protein kinase C, gamma
increases expression
EXP
Ketamine results in increased expression of PRKCG mRNA
CTD
PMID:20080153
NCBI chr 1:74,748,272...74,777,611
Ensembl chr 1:65,832,855...65,859,384
G
Prl
prolactin
decreases expression
EXP
Ketamine results in decreased expression of PRL protein
CTD
PMID:32153215
NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062
G
Prmt2
protein arginine methyltransferase 2
decreases expression
EXP
Ketamine results in decreased expression of PRMT2 mRNA
CTD
PMID:20080153
NCBI chr20:12,391,388...12,420,096
Ensembl chr20:12,394,798...12,420,643
G
Prpf38b
pre-mRNA processing factor 38B
decreases expression
EXP
Ketamine results in decreased expression of PRPF38B mRNA
CTD
PMID:20080153
NCBI chr 2:199,241,312...199,250,342
Ensembl chr 2:196,553,225...196,562,250
G
Prpf4b
pre-mRNA processing factor 4B
decreases expression
EXP
Ketamine results in decreased expression of PRPF4B mRNA
CTD
PMID:20080153
NCBI chr17:30,190,721...30,230,153
Ensembl chr17:29,985,343...30,019,625
G
Prr16
proline rich 16
decreases expression
EXP
Ketamine results in decreased expression of PRR16 mRNA
CTD
PMID:20080153
NCBI chr18:46,622,816...46,963,251
Ensembl chr18:44,424,616...44,632,329
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Psap
prosaposin
increases expression
EXP
Ketamine results in increased expression of PSAP mRNA
CTD
PMID:20080153
NCBI chr20:28,756,951...28,783,422
Ensembl chr20:28,214,271...28,240,498
G
Ptchd1
patched domain containing 1
decreases expression
EXP
Ketamine results in decreased expression of PTCHD1 mRNA
CTD
PMID:20080153
NCBI chr X:43,496,907...43,548,413
Ensembl chr X:39,681,910...39,733,519
G
Ptgds
prostaglandin D2 synthase
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of PTGDS mRNA
CTD
PMID:16635253
NCBI chr 3:28,680,044...28,682,978
Ensembl chr 3:8,281,899...8,284,833
G
Ptgfrn
prostaglandin F2 receptor inhibitor
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of PTGFRN mRNA
CTD
PMID:16635253
NCBI chr 2:191,158,166...191,233,432
Ensembl chr 2:188,469,521...188,544,795
G
Ptk2
protein tyrosine kinase 2
decreases expression
EXP
Ketamine results in decreased expression of PTK2 mRNA
CTD
PMID:20080153
NCBI chr 7:107,015,730...107,220,865
Ensembl chr 7:105,126,728...105,331,783
G
Ptk2b
protein tyrosine kinase 2 beta
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of PTK2B mRNA
CTD
PMID:16635253
NCBI chr15:44,536,275...44,656,754
Ensembl chr15:40,360,723...40,481,282
G
Ptpn5
protein tyrosine phosphatase, non-receptor type 5
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of PTPN5 mRNA
CTD
PMID:16635253
NCBI chr 1:106,756,896...106,817,369
Ensembl chr 1:97,620,642...97,679,882
G
Ptprh
protein tyrosine phosphatase, receptor type, H
decreases expression
EXP
Ketamine results in decreased expression of PTPRH mRNA
CTD
PMID:20080153
NCBI chr 1:78,272,414...78,318,977
Ensembl chr 1:69,242,321...69,285,077
G
Ptprn
protein tyrosine phosphatase, receptor type, N
increases expression
EXP
Ketamine results in increased expression of PTPRN mRNA
CTD
PMID:20080153
NCBI chr 9:84,189,676...84,205,364
Ensembl chr 9:76,741,016...76,756,190
G
Ptprr
protein tyrosine phosphatase, receptor type, R
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of PTPRR mRNA
CTD
PMID:16635253
NCBI chr 7:53,548,611...53,815,632
Ensembl chr 7:51,662,595...51,929,603
G
Ptpru
protein tyrosine phosphatase, receptor type, U
increases expression
EXP
Ketamine results in increased expression of PTPRU mRNA
CTD
PMID:20080153
NCBI chr 5:149,234,624...149,308,857
Ensembl chr 5:143,950,965...144,024,768
G
Pvalb
parvalbumin
multiple interactions decreases expression
ISO EXP
acetovanillone inhibits the reaction [Ketamine results in decreased expression of PVALB protein] [ampullosporin co-treated with Ketamine] results in increased expression of PVALB mRNA
CTD
PMID:16635253 PMID:18063801
NCBI chr 7:111,653,820...111,668,469
Ensembl chr 7:109,772,593...109,784,561
G
Pwwp3a
PWWP domain containing 3A, DNA repair factor
decreases expression
EXP
Ketamine results in decreased expression of PWWP3A mRNA
CTD
PMID:20080153
NCBI chr 7:9,465,180...9,482,053
Ensembl chr 7:9,465,195...9,481,966
G
Pygm
glycogen phosphorylase, muscle associated
increases expression
EXP
Ketamine results in increased expression of PYGM mRNA
CTD
PMID:20080153
NCBI chr 1:213,119,805...213,134,622
Ensembl chr 1:203,690,533...203,705,368
G
Rab26
RAB26, member RAS oncogene family
increases expression
EXP
Ketamine results in increased expression of RAB26 mRNA
CTD
PMID:20080153
NCBI chr10:14,057,942...14,062,602
Ensembl chr10:13,553,395...13,558,030
G
Ramp1
receptor activity modifying protein 1
increases expression
EXP
Ketamine results in increased expression of RAMP1 mRNA
CTD
PMID:20080153
NCBI chr 9:99,213,031...99,263,696
Ensembl chr 9:91,781,285...91,816,151
G
Rasa1
RAS p21 protein activator 1
decreases expression
EXP
Ketamine results in decreased expression of RASA1 mRNA
CTD
PMID:20080153
NCBI chr 2:17,593,136...17,676,707
Ensembl chr 2:15,857,980...15,940,854
G
Rasd2
RASD family, member 2
increases expression
EXP
Ketamine results in increased expression of RASD2 mRNA
CTD
PMID:20080153
NCBI chr19:13,600,028...13,610,753
Ensembl chr19:13,594,291...13,605,016
G
Rasgrf1
RAS protein-specific guanine nucleotide-releasing factor 1
increases expression
EXP
Ketamine results in increased expression of RASGRF1 mRNA
CTD
PMID:20080153
NCBI chr 8:99,324,986...99,454,099
Ensembl chr 8:90,445,154...90,574,269
G
Rasl11a
RAS-like family 11 member A
increases expression
EXP
Ketamine results in increased expression of RASL11A mRNA
CTD
PMID:20080153
NCBI chr12:13,372,023...13,374,784
Ensembl chr12:8,258,159...8,262,576
G
Rasl11b
RAS-like family 11 member B
increases expression
EXP
Ketamine results in increased expression of RASL11B mRNA
CTD
PMID:20080153
NCBI chr14:34,369,029...34,373,250
Ensembl chr14:34,014,509...34,019,152
G
Rassf2
Ras association domain family member 2
decreases expression
EXP
Ketamine results in decreased expression of RASSF2 mRNA
CTD
PMID:20080153
NCBI chr 3:139,697,187...139,733,402
Ensembl chr 3:119,245,821...119,280,431
G
Rassf5
Ras association domain family member 5
increases expression
EXP
Ketamine results in increased expression of RASSF5 mRNA
CTD
PMID:20080153
NCBI chr13:45,189,768...45,255,277
Ensembl chr13:42,637,549...42,703,024
G
Rb1
RB transcriptional corepressor 1
decreases expression
EXP
Ketamine results in decreased expression of RB1 mRNA
CTD
PMID:20080153
NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
G
Rbbp6
RB binding protein 6, ubiquitin ligase
increases expression
EXP
Ketamine results in increased expression of RBBP6 mRNA
CTD
PMID:20080153
NCBI chr 1:177,503,988...177,537,397
Ensembl chr 1:177,503,313...177,535,678
G
Rbbp8
RB binding protein 8, endonuclease
decreases expression
EXP
Ketamine results in decreased expression of RBBP8 mRNA
CTD
PMID:20080153
NCBI chr18:3,198,188...3,263,643
Ensembl chr18:2,921,286...2,988,846
G
Rbm12b
RNA binding motif protein 12B
decreases expression
EXP
Ketamine results in decreased expression of RBM12B mRNA
CTD
PMID:20080153
NCBI chr 5:30,394,756...30,507,428
Ensembl chr 5:25,590,493...25,611,245
G
Rbm4
RNA binding motif protein 4
decreases expression
EXP
Ketamine results in decreased expression of RBM4 mRNA
CTD
PMID:20080153
NCBI chr 1:211,507,845...211,516,907
Ensembl chr 1:202,085,279...202,105,380
G
Rbm4b
RNA binding motif protein 4B
decreases expression
EXP
Ketamine results in decreased expression of RBM4B mRNA
CTD
PMID:20080153
NCBI chr 1:211,477,337...211,487,428
Ensembl chr 1:202,047,927...202,058,020
G
Rbms1
RNA binding motif, single stranded interacting protein 1
decreases expression
EXP
Ketamine results in decreased expression of RBMS1 mRNA
CTD
PMID:20080153
NCBI chr 3:45,195,828...45,420,406
Ensembl chr 3:45,197,972...45,420,376
G
Rbp4
retinol binding protein 4
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of RBP mRNA
CTD
PMID:16635253
NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:235,893,917...235,901,399
G
Recql
RecQ like helicase
decreases expression
EXP
Ketamine results in decreased expression of RECQL mRNA
CTD
PMID:20080153
NCBI chr 4:177,039,351...177,063,968
Ensembl chr 4:175,304,117...175,332,945
G
Reep5
receptor accessory protein 5
decreases expression
EXP
Ketamine results in decreased expression of REEP5 mRNA
CTD
PMID:20080153
NCBI chr18:26,219,528...26,257,505
Ensembl chr18:25,945,381...25,976,509
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions increases phosphorylation
EXP
TRPV4 protein affects the reaction [Ketamine results in increased phosphorylation of RELA protein]
CTD
PMID:33536391
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
G
Rem2
RRAD and GEM like GTPase 2
decreases expression
EXP
Ketamine results in decreased expression of REM2 mRNA
CTD
PMID:20080153
NCBI chr15:27,933,950...27,938,429
Ensembl chr15:27,933,950...27,938,429
G
Ren
renin
increases expression
ISO
Ketamine results in increased expression of REN protein
CTD
PMID:6349867
NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489
G
Resp18
regulated endocrine-specific protein 18
increases expression
EXP
Ketamine results in increased expression of RESP18 mRNA
CTD
PMID:20080153
NCBI chr 9:84,213,844...84,220,186
Ensembl chr 9:76,764,590...76,778,722
G
Rev1
REV1, DNA directed polymerase
increases expression
EXP
Ketamine results in increased expression of REV1 mRNA
CTD
PMID:20080153
NCBI chr 9:40,278,100...40,351,764
Ensembl chr 9:40,278,101...40,351,576
G
Rgs12
regulator of G-protein signaling 12
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of RGS12 mRNA
CTD
PMID:16635253
NCBI chr14:79,940,561...80,048,637
Ensembl chr14:75,715,934...75,794,596
G
Rgs19
regulator of G-protein signaling 19
decreases expression
EXP
Ketamine results in decreased expression of RGS19 mRNA
CTD
PMID:20080153
NCBI chr 3:189,182,041...189,190,494
Ensembl chr 3:168,804,874...168,810,097
G
Rgs2
regulator of G-protein signaling 2
decreases expression
EXP
Ketamine results in decreased expression of RGS2 mRNA
CTD
PMID:20080153
NCBI chr13:58,350,063...58,352,666
Ensembl chr13:55,798,829...55,802,385
G
Rgs3
regulator of G-protein signaling 3
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of RGS3 mRNA
CTD
PMID:16635253
NCBI chr 5:81,037,588...81,177,446
Ensembl chr 5:76,022,001...76,161,894
G
Rgs4
regulator of G-protein signaling 4
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of RGS4 mRNA
CTD
PMID:16635253
NCBI chr13:84,469,593...84,475,884
Ensembl chr13:81,936,775...81,943,068
G
Rgs9
regulator of G-protein signaling 9
increases expression
EXP
Ketamine results in increased expression of RGS9 mRNA
CTD
PMID:20080153
NCBI chr10:94,696,556...94,770,387
Ensembl chr10:94,197,054...94,270,892
G
Rnase4
ribonuclease A family member 4
increases expression
EXP
Ketamine results in increased expression of RNASE4 mRNA
CTD
PMID:20080153
NCBI chr15:26,786,287...26,803,634
Ensembl chr15:24,312,464...24,330,117
G
Rnd3
Rho family GTPase 3
decreases expression
EXP
Ketamine results in decreased expression of RND3 mRNA
CTD
PMID:20080153
NCBI chr 3:55,981,142...55,998,494
Ensembl chr 3:35,571,143...35,589,327
G
Rnf112
ring finger protein 112
increases expression
EXP
Ketamine results in increased expression of RNF112 mRNA
CTD
PMID:20080153
NCBI chr10:46,620,602...46,655,745
Ensembl chr10:46,121,148...46,126,699
G
Rnf138
ring finger protein 138
decreases expression
EXP
Ketamine results in decreased expression of RNF138 mRNA
CTD
PMID:20080153
NCBI chr18:12,558,430...12,590,849
Ensembl chr18:12,291,590...12,315,930
G
Rnf31
ring finger protein 31
increases expression
EXP
Ketamine results in increased expression of RNF31 mRNA
CTD
PMID:20080153
NCBI chr15:33,053,450...33,065,285
Ensembl chr15:29,083,631...29,101,915
G
Rnls
renalase, FAD-dependent amine oxidase
increases expression
EXP
Ketamine results in increased expression of RNLS mRNA
CTD
PMID:20080153
NCBI chr 1:240,450,702...240,723,472
Ensembl chr 1:231,037,486...231,309,823
G
Rora
RAR-related orphan receptor A
increases expression
EXP
Ketamine results in increased expression of RORA mRNA
CTD
PMID:20080153
NCBI chr 8:78,182,710...78,915,730
Ensembl chr 8:69,301,733...70,025,931
G
Rpf2
ribosome production factor 2 homolog
decreases expression
EXP
Ketamine results in decreased expression of RPF2 mRNA
CTD
PMID:20080153
NCBI chr20:45,184,511...45,205,983
Ensembl chr20:43,629,951...43,651,509
G
Rpl24
ribosomal protein L24
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of RPL24 mRNA
CTD
PMID:16635253
NCBI chr11:58,122,997...58,128,405
Ensembl chr11:44,653,937...44,659,370
G
Rps6ka1
ribosomal protein S6 kinase A1
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of RPS6KA1 mRNA
CTD
PMID:16635253
NCBI chr 5:151,362,819...151,402,064
Ensembl chr 5:146,079,021...146,118,272
G
Rpusd3
RNA pseudouridine synthase D3
increases expression
EXP
Ketamine results in increased expression of RPUSD3 mRNA
CTD
PMID:20080153
NCBI chr 4:148,108,857...148,118,246
Ensembl chr 4:146,558,562...146,562,794
G
Rras2
RAS related 2
decreases expression
EXP
Ketamine results in decreased expression of RRAS2 mRNA
CTD
PMID:20080153
NCBI chr 1:177,668,143...177,737,551
Ensembl chr 1:168,233,693...168,303,111
G
Rrm2
ribonucleotide reductase regulatory subunit M2
decreases expression
EXP
Ketamine results in decreased expression of RRM2 mRNA
CTD
PMID:20080153
NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:41,340,557...41,346,773
G
Rrp1b
ribosomal RNA processing 1B
increases expression
EXP
Ketamine results in increased expression of RRP1B mRNA
CTD
PMID:20080153
NCBI chr20:10,122,825...10,148,404
Ensembl chr20:10,123,125...10,147,928
G
Rrp7a
ribosomal RNA processing 7 homolog A
decreases expression
EXP
Ketamine results in decreased expression of RRP7A mRNA
CTD
PMID:20080153
NCBI chr 7:116,142,976...116,152,874
Ensembl chr 7:114,256,472...114,272,817
G
RT1-S3
RT1 class Ib, locus S3
increases expression
EXP
Ketamine results in increased expression of RT1-S3 mRNA
CTD
PMID:20080153
NCBI chr20:2,675,463...2,680,229
Ensembl chr20:2,670,709...2,675,411
G
RT1-T24-4
RT1 class I, locus T24, gene 4
increases expression
EXP
Ketamine results in increased expression of RT1-T24-4 mRNA
CTD
PMID:20080153
NCBI chr20:2,689,329...2,749,848
Ensembl chr20:2,684,515...2,692,511 Ensembl chr20:2,684,515...2,692,511
G
Rtkn
rhotekin
increases expression
EXP
Ketamine results in increased expression of RTKN mRNA
CTD
PMID:20080153
NCBI chr 4:117,198,496...117,215,660
Ensembl chr 4:115,640,774...115,657,952
G
Rundc3a
RUN domain containing 3A
increases expression
EXP
Ketamine results in increased expression of RUNDC3A mRNA
CTD
PMID:20080153
NCBI chr10:87,852,746...87,861,903
Ensembl chr10:87,352,646...87,361,765
G
Rwdd2a
RWD domain containing 2A
increases expression
EXP
Ketamine results in increased expression of RWDD2A mRNA
CTD
PMID:20080153
NCBI chr 8:87,536,153...87,539,301
Ensembl chr 8:87,536,176...87,539,300
G
Rxfp1
relaxin family peptide receptor 1
decreases expression
EXP
Ketamine results in decreased expression of RXFP1 mRNA
CTD
PMID:20080153
NCBI chr 2:167,070,414...167,191,616
Ensembl chr 2:164,774,799...164,893,412
G
Rxrg
retinoid X receptor gamma
decreases expression
EXP
Ketamine results in decreased expression of RXRG mRNA
CTD
PMID:20080153
NCBI chr13:82,276,330...82,318,097
Ensembl chr13:79,743,563...79,785,167
G
S100a11
S100 calcium binding protein A11
decreases expression
EXP
Ketamine results in decreased expression of S100A11 mRNA
CTD
PMID:20080153
NCBI chr 2:181,875,132...181,880,542
Ensembl chr 2:179,191,715...179,197,044
G
S100a4
S100 calcium-binding protein A4
increases expression
EXP ISO
Ketamine results in increased expression of S100A4 mRNA
CTD
PMID:20080153 PMID:28331066
NCBI chr 2:178,388,529...178,390,838
Ensembl chr 2:176,091,804...176,093,254
G
S100b
S100 calcium binding protein B
increases expression
EXP
Ketamine results in increased expression of S100B mRNA
CTD
PMID:20080153
NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,881...12,394,743
G
S1pr2
sphingosine-1-phosphate receptor 2
decreases expression
EXP
Ketamine results in decreased expression of S1PR2 mRNA
CTD
PMID:20080153
NCBI chr 8:27,779,452...27,790,344
Ensembl chr 8:19,502,627...19,523,574
G
Samd9l
sterile alpha motif domain containing 9 like
decreases expression
EXP
Ketamine results in decreased expression of SAMD9L mRNA
CTD
PMID:20080153
NCBI chr 4:32,316,748...32,331,112
Ensembl chr 4:31,361,669...31,376,415
G
Satb2
SATB homeobox 2
decreases expression
EXP
Ketamine results in decreased expression of SATB2 mRNA
CTD
PMID:20080153
NCBI chr 9:65,842,351...66,028,569
Ensembl chr 9:58,350,246...58,530,707
G
Scaper
S-phase cyclin A-associated protein in the ER
decreases expression
EXP
Ketamine results in decreased expression of SCAPER mRNA
CTD
PMID:20080153
NCBI chr 8:64,828,789...65,228,240
Ensembl chr 8:55,933,306...56,332,122
G
Scara3
scavenger receptor class A, member 3
increases expression
EXP
Ketamine results in increased expression of SCARA3 mRNA
CTD
PMID:20080153
NCBI chr15:44,315,422...44,348,416
Ensembl chr15:40,140,161...40,172,894
G
Scarf2
scavenger receptor class F, member 2
increases expression
EXP
Ketamine results in increased expression of SCARF2 mRNA
CTD
PMID:20080153
NCBI chr11:96,680,237...96,691,686
Ensembl chr11:83,175,963...83,187,348
G
Scd
stearoyl-CoA desaturase
increases expression
EXP
Ketamine results in increased expression of SCD1 mRNA
CTD
PMID:20080153
NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
G
Scn4b
sodium voltage-gated channel beta subunit 4
increases expression
EXP
Ketamine results in increased expression of SCN4B mRNA
CTD
PMID:20080153
NCBI chr 8:54,343,873...54,359,046
Ensembl chr 8:45,446,215...45,462,292
G
Sdc1
syndecan 1
decreases expression multiple interactions
EXP
Ketamine results in decreased expression of SDC1 mRNA [ampullosporin co-treated with Ketamine] results in increased expression of SDC1 mRNA
CTD
PMID:16635253 PMID:20080153
NCBI chr 6:37,282,041...37,304,503
Ensembl chr 6:31,562,739...31,585,264
G
Sdsl
serine dehydratase-like
increases expression
EXP
Ketamine results in increased expression of SDSL mRNA
CTD
PMID:20080153
NCBI chr12:36,099,693...36,109,914
Ensembl chr12:36,099,693...36,109,906
G
Senp7
SUMO specific peptidase 7
decreases expression
EXP
Ketamine results in decreased expression of SENP7 mRNA
CTD
PMID:20080153
NCBI chr11:57,892,801...58,053,213
Ensembl chr11:44,423,735...44,564,711
G
Septin4
septin 4
increases expression
EXP
Ketamine results in increased expression of SEPTIN4 mRNA
CTD
PMID:20080153
NCBI chr10:72,863,969...72,888,018
Ensembl chr10:72,366,873...72,390,768
G
Serpinb1a
serpin family B member 1A
increases expression
EXP
Ketamine results in increased expression of SERPINB1A mRNA
CTD
PMID:20080153
NCBI chr17:31,799,446...31,807,853
Ensembl chr17:31,590,677...31,599,102
G
Sesn1
sestrin 1
increases expression
EXP
Ketamine results in increased expression of SESN1 mRNA
CTD
PMID:20080153
NCBI chr20:46,876,918...46,970,010
Ensembl chr20:45,294,871...45,387,697
G
Setmar
SET domain and mariner transposase fusion gene
decreases expression
EXP
Ketamine results in decreased expression of SETMAR mRNA
CTD
PMID:20080153
NCBI chr 4:142,602,066...142,614,208
Ensembl chr 4:141,046,069...141,058,197
G
Sfpq
splicing factor proline and glutamine rich
decreases expression
EXP
Ketamine results in decreased expression of SFPQ mRNA
CTD
PMID:20080153
NCBI chr 5:144,621,678...144,637,930
Ensembl chr 5:139,338,075...139,353,472
G
Sh2b2
SH2B adaptor protein 2
decreases expression
EXP
Ketamine results in decreased expression of SH2B2 mRNA
CTD
PMID:20080153
NCBI chr12:26,063,812...26,093,468
Ensembl chr12:20,429,043...20,456,844
G
Sh3bp5
SH3-domain binding protein 5
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of SH3BP5 mRNA
CTD
PMID:16635253
NCBI chr16:6,589,877...6,676,524
Ensembl chr16:6,583,465...6,698,975
G
Shoc2
SHOC2 leucine-rich repeat scaffold protein
decreases expression
EXP
Ketamine results in decreased expression of SHOC2 mRNA
CTD
PMID:20080153
NCBI chr 1:262,964,345...263,052,898
Ensembl chr 1:252,959,723...253,047,337
G
Slain2
SLAIN motif family, member 2
decreases expression
EXP
Ketamine results in decreased expression of SLAIN2 mRNA
CTD
PMID:20080153
NCBI chr14:35,590,050...35,667,734
Ensembl chr14:35,236,041...35,304,678
G
Slc15a5
solute carrier family 15, member 5
decreases expression
EXP
Ketamine results in decreased expression of SLC15A5 mRNA
CTD
PMID:20080153
NCBI chr 4:172,609,293...172,702,893
Ensembl chr 4:170,878,021...170,971,620
G
Slc17a7
solute carrier family 17 member 7
increases expression
EXP
Ketamine results in increased expression of SLC17A7 mRNA
CTD
PMID:20080153
NCBI chr 1:104,786,172...104,798,049
Ensembl chr 1:95,649,745...95,661,588
G
Slc1a2
solute carrier family 1 member 2
increases expression multiple interactions
EXP ISO
Ketamine results in increased expression of SLC1A2 mRNA [Guanosine co-treated with Ketamine] results in increased expression of SLC1A2 protein
CTD
PMID:20080153 PMID:36878458
NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:89,005,129...89,126,498
G
Slc1a6
solute carrier family 1 member 6
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of SLC1A6 mRNA
CTD
PMID:16635253
NCBI chr 7:11,492,422...11,521,007
Ensembl chr 7:10,841,837...10,870,449
G
Slc20a2
solute carrier family 20 member 2
increases expression
EXP
Ketamine results in increased expression of SLC20A2 mRNA
CTD
PMID:20080153
NCBI chr16:76,163,315...76,253,881
Ensembl chr16:69,460,462...69,521,711
G
Slc25a1
solute carrier family 25 member 1
decreases expression
EXP
Ketamine results in decreased expression of SLC25A1 mRNA
CTD
PMID:20080153
NCBI chr11:96,560,054...96,563,071
Ensembl chr11:83,055,748...83,058,781
G
Slc26a6
solute carrier family 26 member 6
increases expression
EXP
Ketamine results in increased expression of SLC26A6 mRNA
CTD
PMID:20080153
NCBI chr 8:118,438,110...118,448,271
Ensembl chr 8:109,559,642...109,569,778
G
Slc2a2
solute carrier family 2 member 2
increases expression
EXP
Ketamine results in increased expression of SLC2A2 mRNA
CTD
PMID:20080153
NCBI chr 2:113,537,884...113,568,422
Ensembl chr 2:111,611,774...111,639,933
G
Slc2a5
solute carrier family 2 member 5
increases expression
EXP
Ketamine results in increased expression of SLC2A5 mRNA
CTD
PMID:20080153
NCBI chr 5:165,857,412...165,892,928
Ensembl chr 5:160,583,234...160,611,106
G
Slc2a6
solute carrier family 2 member 6
decreases expression
EXP
Ketamine results in decreased expression of SLC2A6 mRNA
CTD
PMID:20080153
NCBI chr 3:30,746,472...30,753,287
Ensembl chr 3:10,348,395...10,355,208
G
Slc30a6
solute carrier family 30 member 6
decreases expression
EXP
Ketamine results in decreased expression of SLC30A6 mRNA
CTD
PMID:20080153
NCBI chr 6:26,772,804...26,802,656
Ensembl chr 6:21,020,931...21,050,785
G
Slc32a1
solute carrier family 32 member 1
increases expression
EXP
Ketamine results in increased expression of SLC32A1 mRNA
CTD
PMID:20080153
NCBI chr 3:167,687,245...167,691,714
Ensembl chr 3:147,267,373...147,271,844
G
Slc35e3
solute carrier family 35, member E3
decreases expression
EXP
Ketamine results in decreased expression of SLC35E3 mRNA
CTD
PMID:20080153
NCBI chr 7:55,222,962...55,236,022
Ensembl chr 7:53,337,095...53,350,165
G
Slc38a3
solute carrier family 38, member 3
increases expression
EXP
Ketamine results in increased expression of SLC38A3 mRNA
CTD
PMID:20080153
NCBI chr 8:117,202,534...117,220,310
Ensembl chr 8:108,323,894...108,339,988
G
Slc38a5
solute carrier family 38, member 5
decreases expression
EXP
Ketamine results in decreased expression of SLC38A5 mRNA
CTD
PMID:20080153
NCBI chr X:16,885,701...16,894,470
Ensembl chr X:14,213,729...14,222,498
G
Slc39a12
solute carrier family 39 member 12
increases expression
EXP
Ketamine results in increased expression of SLC39A12 mRNA
CTD
PMID:20080153
NCBI chr17:82,262,303...82,348,974
Ensembl chr17:77,353,805...77,440,353
G
Slc45a4
solute carrier family 45, member 4
increases expression
EXP
Ketamine results in increased expression of SLC45A4 mRNA
CTD
PMID:20080153
NCBI chr 7:107,370,826...107,459,163
Ensembl chr 7:105,481,792...105,550,170
G
Slc52a2
solute carrier family 52 member 2
decreases expression
EXP
Ketamine results in decreased expression of SLC52A2 mRNA
CTD
PMID:20080153
NCBI chr 7:110,126,632...110,146,647
Ensembl chr 7:108,262,612...108,268,034
G
Slc5a3
solute carrier family 5 member 3
decreases expression
EXP
Ketamine results in decreased expression of SLC5A3 mRNA
CTD
PMID:20080153
NCBI chr11:44,799,787...44,802,233
Ensembl chr11:31,295,476...31,318,883
G
Slc6a2
solute carrier family 6 member 2
multiple interactions decreases activity
ISO
[Ketamine co-treated with Xylenes] results in decreased activity of SLC6A2 protein Ketamine results in decreased activity of SLC6A2 protein
CTD
PMID:17934728
NCBI chr19:30,183,289...30,228,292
Ensembl chr19:14,010,386...14,050,357
G
Slc6a3
solute carrier family 6 member 3
multiple interactions
ISO
Ketamine inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]
CTD
PMID:31009648
NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413
G
Slc7a10
solute carrier family 7 member 10
increases expression
EXP
Ketamine results in increased expression of SLC7A10 mRNA
CTD
PMID:20080153
NCBI chr 1:96,966,030...96,982,020
Ensembl chr 1:87,829,175...87,845,071
G
Slc9a1
solute carrier family 9 member A1
increases expression
EXP
Ketamine results in increased expression of SLC9A1 mRNA
CTD
PMID:20080153
NCBI chr 5:150,859,412...150,913,525
Ensembl chr 5:145,576,334...145,629,624
G
Slc9a6
solute carrier family 9 member A6
decreases expression
ISO
Ketamine results in decreased expression of SLC9A6 protein
CTD
PMID:35378374
NCBI chr X:139,468,045...139,524,111
Ensembl chr X:134,420,756...134,485,375
G
Slco1c1
solute carrier organic anion transporter family, member 1c1
decreases expression
EXP
Ketamine results in decreased expression of SLCO1C1 mRNA
CTD
PMID:20080153
NCBI chr 4:176,197,736...176,244,401
Ensembl chr 4:174,466,631...174,513,289
G
Slco5a1
solute carrier organic anion transporter family, member 5A1
decreases expression
EXP
Ketamine results in decreased expression of SLCO5A1 mRNA
CTD
PMID:20080153
NCBI chr 5:11,012,001...11,141,180
Ensembl chr 5:6,228,973...6,352,913
G
Sltm
SAFB-like, transcription modulator
decreases expression
EXP
Ketamine results in decreased expression of SLTM mRNA
CTD
PMID:20080153
NCBI chr 8:80,096,555...80,142,668
Ensembl chr 8:71,216,612...71,261,825
G
Smarca1
SNF2 related chromatin remodeling ATPase 1
decreases expression
EXP
Ketamine results in decreased expression of SMARCA1 mRNA
CTD
PMID:20080153
NCBI chr X:131,858,148...131,944,639
Ensembl chr X:126,994,947...127,066,347
G
Smc6
structural maintenance of chromosomes 6
decreases expression
EXP
Ketamine results in decreased expression of SMC6 mRNA
CTD
PMID:20080153
NCBI chr 6:39,697,810...39,752,275
Ensembl chr 6:33,978,716...34,031,746
G
Smoc2
SPARC related modular calcium binding 2
decreases expression
EXP
Ketamine results in decreased expression of SMOC2 mRNA
CTD
PMID:20080153
NCBI chr 1:63,935,627...64,064,952
Ensembl chr 1:55,262,530...55,391,693
G
Smox
spermine oxidase
increases expression
EXP
Ketamine results in increased expression of SMOX mRNA
CTD
PMID:20080153
NCBI chr 3:139,184,793...139,220,174
Ensembl chr 3:118,731,900...118,765,710 Ensembl chr X:118,731,900...118,765,710
G
Smpd3
sphingomyelin phosphodiesterase 3
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in decreased expression of SMPD3 mRNA
CTD
PMID:16635253
NCBI chr19:51,072,209...51,155,639
Ensembl chr19:34,162,341...34,245,749
G
Snai1
snail family transcriptional repressor 1
increases expression
ISO
Ketamine results in increased expression of SNAI1 mRNA
CTD
PMID:28331066
NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969
G
Snai2
snail family transcriptional repressor 2
increases expression
ISO
Ketamine results in increased expression of SNAI2 mRNA
CTD
PMID:28331066
NCBI chr11:99,686,934...99,690,349
Ensembl chr11:86,181,909...86,186,200
G
Snapc3
small nuclear RNA activating complex, polypeptide 3
decreases expression
EXP
Ketamine results in decreased expression of SNAPC3 mRNA
CTD
PMID:20080153
NCBI chr 5:102,863,867...102,890,573
Ensembl chr 5:97,817,947...97,844,650
G
Snorc
secondary ossification center associated regulator of chondrocyte maturation
increases expression
EXP
Ketamine results in increased expression of SNORC mRNA
CTD
PMID:20080153
NCBI chr 9:95,574,943...95,593,394
Ensembl chr 9:88,140,419...88,145,891
G
Snta1
syntrophin, alpha 1
increases expression
EXP
Ketamine results in increased expression of SNTA1 mRNA
CTD
PMID:20080153
NCBI chr 3:163,336,509...163,366,954
Ensembl chr 3:142,876,296...142,906,709
G
Sntg2
syntrophin, gamma 2
decreases expression
EXP
Ketamine results in decreased expression of SNTG2 mRNA
CTD
PMID:20080153
NCBI chr 6:52,529,481...52,730,972
Ensembl chr 6:46,801,377...47,003,372
G
Snx16
sorting nexin 16
decreases expression
EXP
Ketamine results in decreased expression of SNX16 mRNA
CTD
PMID:20080153
NCBI chr 2:91,335,896...91,357,622
Ensembl chr 2:91,336,092...91,357,619
G
Socs3
suppressor of cytokine signaling 3
multiple interactions
ISO
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of SOCS3 mRNA]
CTD
PMID:22245128
NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787
G
Socs5
suppressor of cytokine signaling 5
decreases expression
EXP
Ketamine results in decreased expression of SOCS5 mRNA
CTD
PMID:20080153
NCBI chr 6:13,235,157...13,266,161
Ensembl chr 6:7,481,095...7,514,834
G
Sod3
superoxide dismutase 3
increases expression
EXP
Ketamine results in increased expression of SOD3 mRNA
CTD
PMID:20080153
NCBI chr14:62,822,865...62,828,602
Ensembl chr14:58,609,958...58,615,990
G
Sorcs1
sortilin-related VPS10 domain containing receptor 1
decreases expression
EXP
Ketamine results in decreased expression of SORCS1 mRNA
CTD
PMID:20080153
NCBI chr 1:249,080,662...249,594,520
Ensembl chr 1:249,081,355...249,594,507
G
Sox11
SRY-box transcription factor 11
decreases expression
EXP
Ketamine results in decreased expression of SOX11 mRNA
CTD
PMID:20080153
NCBI chr 6:49,736,773...49,738,794
Ensembl chr 6:44,008,340...44,010,354
G
Sox4
SRY-box transcription factor 4
decreases expression
EXP
Ketamine results in decreased expression of SOX4 mRNA
CTD
PMID:20080153
NCBI chr17:35,876,298...35,881,004
Ensembl chr17:35,667,537...35,673,665
G
Sparc
secreted protein acidic and cysteine rich
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of SPARC mRNA
CTD
PMID:16635253
NCBI chr10:40,017,065...40,038,816
Ensembl chr10:39,516,406...39,538,396
G
Spatc1
spermatogenesis and centriole associated 1
decreases expression
EXP
Ketamine results in decreased expression of SPATC1 mRNA
CTD
PMID:20080153
NCBI chr 7:109,863,794...109,888,145
Ensembl chr 7:107,983,796...108,007,479
G
Spdya
speedy/RINGO cell cycle regulator family member A
increases expression
EXP
Ketamine results in increased expression of SPDYA mRNA
CTD
PMID:20080153
NCBI chr 6:29,619,415...29,675,030
Ensembl chr 6:23,910,223...23,954,850
G
Spp1
secreted phosphoprotein 1
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of SPP1 mRNA
CTD
PMID:16635253
NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162
G
Spsb1
splA/ryanodine receptor domain and SOCS box containing 1
increases expression
EXP
Ketamine results in increased expression of SPSB1 mRNA
CTD
PMID:20080153
NCBI chr 5:165,641,255...165,701,482
Ensembl chr 5:160,358,308...160,418,468
G
Sptbn4
spectrin, beta, non-erythrocytic 4
increases expression
EXP
Ketamine results in increased expression of SPTBN4 mRNA
CTD
PMID:20080153
NCBI chr 1:91,778,379...91,865,970
Ensembl chr 1:82,650,751...82,737,228
G
Sqle
squalene epoxidase
decreases expression
EXP
Ketamine results in decreased expression of SQLE mRNA
CTD
PMID:20080153
NCBI chr 7:92,758,175...92,773,049
Ensembl chr 7:90,868,011...90,883,618
G
Sqstm1
sequestosome 1
increases expression
ISO
Ketamine results in increased expression of SQSTM1 mRNA; Ketamine results in increased expression of SQSTM1 protein
CTD
PMID:34487425
NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673
G
Srebf1
sterol regulatory element binding transcription factor 1
increases expression
EXP
Ketamine results in increased expression of SREBF1 mRNA
CTD
PMID:20080153
NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650
G
Srpk1
SRSF protein kinase 1
decreases expression
EXP
Ketamine results in decreased expression of SRPK1 mRNA
CTD
PMID:20080153
NCBI chr20:6,645,809...6,682,448
Ensembl chr20:6,645,809...6,682,134
G
Srsf6
serine and arginine rich splicing factor 6
decreases expression
EXP
Ketamine results in decreased expression of SRSF6 mRNA
CTD
PMID:20080153
NCBI chr 3:172,009,072...172,014,395
Ensembl chr 3:151,589,535...151,594,860
G
Ssr1
signal sequence receptor subunit 1
increases expression
EXP
Ketamine results in increased expression of SSR1 mRNA
CTD
PMID:20080153
NCBI chr17:27,039,203...27,067,352
Ensembl chr17:26,833,741...26,861,821
G
Sstr1
somatostatin receptor 1
decreases expression multiple interactions
EXP
Ketamine results in decreased expression of SSTR1 mRNA [ampullosporin co-treated with Ketamine] results in decreased expression of SSTR1 mRNA
CTD
PMID:16635253 PMID:20080153
NCBI chr 6:81,567,237...81,571,759
Ensembl chr 6:75,832,530...75,836,802
G
Sstr3
somatostatin receptor 3
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of SSTR3 mRNA
CTD
PMID:16635253
NCBI chr 7:111,973,049...111,980,250
Ensembl chr 7:110,092,575...110,099,769
G
Stim1
stromal interaction molecule 1
increases expression
EXP
Ketamine results in increased expression of STIM1 mRNA
CTD
PMID:20080153
NCBI chr 1:166,067,450...166,230,733
Ensembl chr 1:156,656,013...156,818,363
G
Sult1a1
sulfotransferase family 1A member 1
increases expression
EXP
Ketamine results in increased expression of SULT1A1 mRNA
CTD
PMID:20080153
NCBI chr 1:190,702,592...190,706,112
Ensembl chr 1:181,272,023...181,275,562
G
Sumf1
sulfatase modifying factor 1
increases expression
EXP
Ketamine results in increased expression of SUMF1 mRNA
CTD
PMID:20080153
NCBI chr 4:141,078,735...141,160,711
Ensembl chr 4:141,078,741...141,160,708
G
Suox
sulfite oxidase
decreases expression
EXP
Ketamine results in decreased expression of SUOX mRNA
CTD
PMID:20080153
NCBI chr 7:1,687,666...1,691,759
Ensembl chr 7:1,103,151...1,107,038
G
Syn1
synapsin I
multiple interactions increases expression
ISO
Ketamine inhibits the reaction [Corticosterone results in decreased expression of SYN1 protein]; Sirolimus inhibits the reaction [Ketamine results in increased expression of SYN1 protein]
CTD
PMID:33022268 PMID:33872575
NCBI chr X:3,725,745...3,780,940
Ensembl chr X:1,172,208...1,227,396
G
Syt12
synaptotagmin 12
increases expression
EXP
Ketamine results in increased expression of SYT12 mRNA
CTD
PMID:20080153
NCBI chr 1:211,158,745...211,189,780
Ensembl chr 1:201,730,371...201,759,609
G
Sytl2
synaptotagmin-like 2
increases expression
EXP
Ketamine results in increased expression of SYTL2 mRNA
CTD
PMID:20080153
NCBI chr 1:153,685,403...153,791,758
Ensembl chr 1:144,273,360...144,379,222
G
Tac3
tachykinin precursor 3
increases expression
EXP
Ketamine results in increased expression of TAC2 mRNA
CTD
PMID:20080153
NCBI chr 7:65,447,817...65,454,427
Ensembl chr 7:63,562,552...63,569,170
G
Tacstd2
tumor-associated calcium signal transducer 2
decreases expression
EXP
Ketamine results in decreased expression of TACSTD2 mRNA
CTD
PMID:20080153
NCBI chr 4:98,037,620...98,039,320
Ensembl chr 4:96,707,951...96,709,650
G
Tafa1
TAFA chemokine like family member 1
decreases expression
EXP
Ketamine results in decreased expression of TAFA1 mRNA
CTD
PMID:20080153
NCBI chr 4:128,738,028...129,244,223
Ensembl chr 4:128,739,313...129,243,777
G
Tagln3
transgelin 3
increases expression
EXP
Ketamine results in increased expression of TAGLN3 protein
CTD
PMID:18504422
NCBI chr11:68,562,482...68,576,058
Ensembl chr11:55,099,743...55,113,485
G
Tax1bp3
Tax1 binding protein 3
decreases expression
EXP
Ketamine results in decreased expression of TAX1BP3 mRNA
CTD
PMID:20080153
NCBI chr10:58,294,357...58,298,875
Ensembl chr10:57,795,382...57,800,363
G
Tbc1d10b
TBC1 domain family, member 10b
decreases expression
EXP
Ketamine results in decreased expression of TBC1D10B mRNA
CTD
PMID:20080153
NCBI chr 1:191,245,472...191,257,128
Ensembl chr 1:181,814,972...181,826,628
G
Tbccd1
TBCC domain containing 1
decreases expression
EXP
Ketamine results in decreased expression of TBCCD1 mRNA
CTD
PMID:20080153
NCBI chr11:78,168,386...78,205,314
Ensembl chr11:78,168,388...78,205,523
G
Tef
TEF transcription factor, PAR bZIP family member
increases expression
EXP
Ketamine results in increased expression of TEF mRNA
CTD
PMID:20080153
NCBI chr 7:115,197,180...115,221,930
Ensembl chr 7:113,317,283...113,341,783
G
Tekt2
tektin 2
increases expression
EXP
Ketamine results in increased expression of TEKT2 mRNA
CTD
PMID:20080153
NCBI chr 5:143,904,185...143,907,724
Ensembl chr 5:138,619,667...138,623,204
G
Tes
testin LIM domain protein
decreases expression
EXP
Ketamine results in decreased expression of TES mRNA
CTD
PMID:20080153
NCBI chr 4:46,331,257...46,369,782
Ensembl chr 4:45,365,285...45,403,829
G
Tesc
tescalcin
increases expression
EXP
Ketamine results in increased expression of TESC mRNA
CTD
PMID:20080153
NCBI chr12:44,182,741...44,216,574
Ensembl chr12:38,521,861...38,555,824
G
Tf
transferrin
increases expression multiple interactions
EXP
Ketamine results in increased expression of TF mRNA [ampullosporin co-treated with Ketamine] results in increased expression of TF mRNA
CTD
PMID:16635253 PMID:20080153
NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:103,767,995...103,816,511
G
Tfap2d
transcription factor AP-2 delta
decreases expression
EXP
Ketamine results in decreased expression of TFAP2D mRNA
CTD
PMID:20080153
NCBI chr 9:29,177,096...29,241,412
Ensembl chr 9:21,680,577...21,740,728
G
Tfe3
transcription factor binding to IGHM enhancer 3
increases expression
EXP
Ketamine results in increased expression of TFE3 mRNA
CTD
PMID:20080153
NCBI chr X:17,401,466...17,414,829
Ensembl chr X:14,729,550...14,742,571
G
Tgfb1
transforming growth factor, beta 1
increases expression increases secretion
EXP ISO
Ketamine results in increased expression of TGFB1 protein Ketamine results in increased expression of TGFB1 mRNA Ketamine results in increased secretion of TGFB1 protein
CTD
PMID:28331066
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
G
Tgfbr1
transforming growth factor, beta receptor 1
increases expression
ISO
Ketamine results in increased expression of TGFBR1 mRNA
CTD
PMID:28331066
NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777
G
Tgfbr2
transforming growth factor, beta receptor 2
increases expression
ISO
Ketamine results in increased expression of TGFBR2 mRNA
CTD
PMID:28331066
NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228
G
Thnsl2
threonine synthase-like 2
increases expression
EXP
Ketamine results in increased expression of THNSL2 mRNA
CTD
PMID:20080153
NCBI chr 4:104,671,305...104,691,084
Ensembl chr 4:103,112,963...103,132,017
G
Thrsp
thyroid hormone responsive
increases expression
EXP
Ketamine results in increased expression of THRSP mRNA
CTD
PMID:20080153
NCBI chr 1:161,134,640...161,138,964
Ensembl chr 1:151,723,086...151,728,075
G
Thumpd3
THUMP domain containing 3
decreases expression
EXP
Ketamine results in decreased expression of THUMPD3 mRNA
CTD
PMID:20080153
NCBI chr 4:147,741,288...147,764,254
Ensembl chr 4:146,185,503...146,211,246
G
Thy1
Thy-1 cell surface antigen
increases expression
EXP
Ketamine results in increased expression of THY1 mRNA
CTD
PMID:20080153
NCBI chr 8:53,286,396...53,291,541
Ensembl chr 8:44,389,513...44,394,659
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Tia1
TIA1 cytotoxic granule-associated RNA binding protein
decreases expression
EXP
Ketamine results in decreased expression of TIA1 mRNA
CTD
PMID:20080153
NCBI chr 4:120,410,180...120,440,676
Ensembl chr 4:118,852,837...118,880,586
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Tifa
TRAF-interacting protein with forkhead-associated domain
increases expression
EXP
Ketamine results in increased expression of TIFA mRNA
CTD
PMID:20080153
NCBI chr 2:218,927,724...218,942,111
Ensembl chr 2:216,234,774...216,267,841
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Tigd2
tigger transposable element derived 2
increases expression
EXP
Ketamine results in increased expression of TIGD2 mRNA
CTD
PMID:20080153
NCBI chr 4:89,744,516...89,747,608
Ensembl chr 4:88,414,518...88,417,785
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Tlcd3a
TLC domain containing 3A
decreases expression
EXP
Ketamine results in decreased expression of TLCD3A mRNA
CTD
PMID:20080153
NCBI chr10:61,556,193...61,563,529
Ensembl chr10:61,058,042...61,065,283
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Tlr4
toll-like receptor 4
multiple interactions
ISO
TLR4 mutant form promotes the reaction [Ketamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; TLR4 mutant form promotes the reaction [Ketamine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]
CTD
PMID:19540866
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
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Tmeff1
transmembrane protein with EGF-like and two follistatin-like domains 1
decreases expression
EXP
Ketamine results in decreased expression of TMEFF1 mRNA
CTD
PMID:20080153
NCBI chr 5:62,910,740...62,996,494
Ensembl chr 5:62,910,740...62,996,493
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Tmeff2
transmembrane protein with EGF-like and two follistatin-like domains 2
decreases expression
EXP
Ketamine results in decreased expression of TMEFF2 mRNA
CTD
PMID:20080153
NCBI chr 9:57,937,873...58,225,372
Ensembl chr 9:50,436,079...50,733,475
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Tmem140
transmembrane protein 140
increases expression
EXP
Ketamine results in increased expression of TMEM140 mRNA
CTD
PMID:20080153
NCBI chr 4:64,503,621...64,514,620
Ensembl chr 4:63,536,168...63,548,455
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Tmem200a
transmembrane protein 200A
decreases expression
EXP
Ketamine results in decreased expression of TMEM200A mRNA
CTD
PMID:20080153
NCBI chr 1:21,142,500...21,242,022
Ensembl chr 1:19,323,829...19,406,453
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Tmem222
transmembrane protein 222
increases expression
EXP
Ketamine results in increased expression of TMEM222 mRNA
CTD
PMID:20080153
NCBI chr 5:150,749,746...150,763,031
Ensembl chr 5:145,465,847...145,484,491
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Tmem248
transmembrane protein 248
increases expression
EXP
Ketamine results in increased expression of TMEM248 mRNA
CTD
PMID:20080153
NCBI chr12:26,430,775...26,457,105
Ensembl chr12:26,432,953...26,457,105
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Tmem74
transmembrane protein 74
decreases expression
EXP
Ketamine results in decreased expression of TMEM74 mRNA
CTD
PMID:20080153
NCBI chr 7:76,814,000...76,822,633
Ensembl chr 7:74,931,694...74,937,934
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Tmem74b
transmembrane protein 74B
decreases expression
EXP
Ketamine results in decreased expression of TMEM74B mRNA
CTD
PMID:20080153
NCBI chr 3:140,219,592...140,224,208
Ensembl chr 3:140,219,412...140,235,872
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Tmpo
thymopoietin
decreases expression
EXP
Ketamine results in decreased expression of TMPO mRNA
CTD
PMID:20080153
NCBI chr 7:27,529,977...27,554,980
Ensembl chr 7:25,586,725...25,667,727
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Tmtc4
transmembrane O-mannosyltransferase targeting cadherins 4
decreases expression
EXP
Ketamine results in decreased expression of TMTC4 mRNA
CTD
PMID:20080153
NCBI chr15:106,406,795...106,463,226
Ensembl chr15:100,000,152...100,056,543
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Tnf
tumor necrosis factor
multiple interactions increases expression affects expression decreases expression
ISO EXP IEP
Ketamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] Ketamine results in increased expression of TNF protein Ketamine co-treated with xylazine inhibits the reaction [lipopolysaccharide increases expression of Tnf protein in serum and mucosa of stomach] [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF mRNA]; [Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of TNF protein]; Ketamine inhibits the reaction [Acetaminophen results in increased expression of TNF protein]; Ketamine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] Ozone inhibits the reaction [Ketamine results in decreased expression of TNF mRNA]; TRPV4 protein affects the reaction [Ketamine results in increased expression of TNF protein]
CTD RGD
PMID:15207037 PMID:15207038 PMID:15720977 PMID:19540866 PMID:22245128 PMID:33536391 PMID:37491939 PMID:12813371 More...
RGD:14995427
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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Tnfaip1
TNF alpha induced protein 1
decreases expression
EXP
Ketamine results in decreased expression of TNFAIP1 mRNA
CTD
PMID:20080153
NCBI chr10:63,915,824...63,930,514
Ensembl chr10:63,417,775...63,432,466
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Tnfrsf11b
TNF receptor superfamily member 11B
decreases expression
EXP
Ketamine results in decreased expression of TNFRSF11B mRNA
CTD
PMID:20080153
NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:85,566,520...85,594,538
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Tnnc2
troponin C2, fast skeletal type
increases expression
EXP
Ketamine results in increased expression of TNNC2 mRNA
CTD
PMID:20080153
NCBI chr 3:173,932,611...173,935,339
Ensembl chr 3:153,513,271...153,516,029
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Tnnt1
troponin T1, slow skeletal type
increases expression
ISO
Ketamine results in increased expression of TNNT1 mRNA
CTD
PMID:19162068
NCBI chr 1:78,349,035...78,359,394
Ensembl chr 1:69,306,362...69,316,721
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Tnpo1
transportin 1
decreases expression
EXP
Ketamine results in decreased expression of TNPO1 mRNA
CTD
PMID:20080153
NCBI chr 2:31,941,731...32,034,366
Ensembl chr 2:30,211,510...30,300,375
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Tns3
tensin 3
increases expression
EXP
Ketamine results in increased expression of TNS3 mRNA
CTD
PMID:20080153
NCBI chr14:87,387,441...87,619,457
Ensembl chr14:83,173,649...83,405,998
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Tp53
tumor protein p53
increases expression
ISO
Ketamine results in increased expression of TP53 protein
CTD
PMID:19919587
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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Tpm1
tropomyosin 1
increases expression
EXP
Ketamine results in increased expression of TPM1 mRNA
CTD
PMID:20080153
NCBI chr 8:76,516,654...76,543,661
Ensembl chr 8:67,635,479...67,662,802
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Tpm4
tropomyosin 4
decreases expression
EXP
Ketamine results in decreased expression of TPM4 mRNA
CTD
PMID:20080153
NCBI chr16:17,718,442...17,732,483
Ensembl chr16:17,683,195...17,705,984
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Tra2a
transformer 2 alpha
decreases expression
EXP
Ketamine results in decreased expression of TRA2A mRNA
CTD
PMID:20080153
NCBI chr 4:79,551,699...79,570,621
Ensembl chr 4:78,220,883...78,239,712
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Traip
TRAF-interacting protein
increases expression
EXP
Ketamine results in increased expression of TRAIP mRNA
CTD
PMID:20080153
NCBI chr 8:117,520,476...117,540,253
Ensembl chr 8:108,641,852...108,661,638
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Trem2
triggering receptor expressed on myeloid cells 2
increases expression
EXP
Ketamine results in increased expression of TREM2 mRNA
CTD
PMID:20080153
NCBI chr 9:20,145,215...20,151,797
Ensembl chr 9:12,647,259...12,654,170
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Trh
thyrotropin releasing hormone
increases expression
EXP
Ketamine results in increased expression of TRH mRNA
CTD
PMID:20080153
NCBI chr 4:126,299,236...126,301,762
Ensembl chr 4:124,742,111...124,744,637
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Trim13
tripartite motif-containing 13
decreases expression
EXP
Ketamine results in decreased expression of TRIM13 mRNA
CTD
PMID:20080153
NCBI chr15:39,909,587...39,948,719
Ensembl chr15:35,734,107...35,772,677
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Trim36
tripartite motif-containing 36
decreases expression
EXP
Ketamine results in decreased expression of TRIM36 mRNA
CTD
PMID:20080153
NCBI chr18:41,047,657...41,099,497
Ensembl chr18:38,861,018...38,912,859
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Trim39
tripartite motif-containing 39
decreases expression
EXP
Ketamine results in decreased expression of TRIM39 mRNA
CTD
PMID:20080153
NCBI chr20:2,008,528...2,022,383
Ensembl chr20:1,983,533...2,020,117
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Trim54
tripartite motif-containing 54
increases expression
EXP
Ketamine results in increased expression of TRIM54 mRNA
CTD
PMID:20080153
NCBI chr 6:30,959,306...30,978,475
Ensembl chr 6:25,239,340...25,258,511
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Trpc3
transient receptor potential cation channel, subfamily C, member 3
multiple interactions decreases expression
EXP
Chir 99021 promotes the reaction [Ketamine results in decreased expression of TRPC3 protein] Ketamine results in decreased expression of TRPC3 mRNA; Ketamine results in decreased expression of TRPC3 protein
CTD
PMID:36334642
NCBI chr 2:121,409,436...121,487,095
Ensembl chr 2:119,481,400...119,558,855
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Trpv2
transient receptor potential cation channel, subfamily V, member 2
decreases expression
EXP
Ketamine results in decreased expression of TRPV2 mRNA
CTD
PMID:20080153
NCBI chr10:47,772,223...47,797,956
Ensembl chr10:47,272,931...47,294,260
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Trpv4
transient receptor potential cation channel, subfamily V, member 4
multiple interactions increases expression
EXP
TRPV4 protein affects the reaction [Ketamine results in decreased activity of CAT protein]; TRPV4 protein affects the reaction [Ketamine results in decreased expression of BCL2 mRNA]; TRPV4 protein affects the reaction [Ketamine results in decreased expression of BCL2 protein]; TRPV4 protein affects the reaction [Ketamine results in increased cleavage of CASP3 protein]; TRPV4 protein affects the reaction [Ketamine results in increased expression of BAX mRNA]; TRPV4 protein affects the reaction [Ketamine results in increased expression of BAX protein]; TRPV4 protein affects the reaction [Ketamine results in increased expression of CASP3 mRNA]; TRPV4 protein affects the reaction [Ketamine results in increased expression of IL1B protein]; TRPV4 protein affects the reaction [Ketamine results in increased expression of IL6 protein]; TRPV4 protein affects the reaction [Ketamine results in increased expression of TNF protein]; TRPV4 protein affects the reaction [Ketamine results in increased phosphorylation of NFKBIA protein]; TRPV4 protein affects the reaction [Ketamine results in increased phosphorylation of RELA protein] Ketamine results in increased expression of TRPV4 mRNA; Ketamine results in increased expression of TRPV4 protein
CTD
PMID:33536391
NCBI chr12:47,599,161...47,638,143
Ensembl chr12:41,938,560...41,977,517
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Tsen2
tRNA splicing endonuclease subunit 2
decreases expression
EXP
Ketamine results in decreased expression of TSEN2 mRNA
CTD
PMID:20080153
NCBI chr 4:150,275,389...150,310,846
Ensembl chr 4:148,602,863...148,638,215
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Tspan14
tetraspanin 14
decreases expression
EXP
Ketamine results in decreased expression of TSPAN14 mRNA
CTD
PMID:20080153
NCBI chr16:16,818,344...16,875,462
Ensembl chr16:16,783,234...16,841,400
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Tspan33
tetraspanin 33
increases expression
EXP
Ketamine results in increased expression of TSPAN33 mRNA
CTD
PMID:20080153
NCBI chr 4:59,270,713...59,294,249
Ensembl chr 4:58,305,437...58,328,940
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Tspo
translocator protein
multiple interactions
EXP
[Ketamine co-treated with Midazolam co-treated with Valproic Acid] inhibits the reaction [[Sarin co-treated with [Atropine co-treated with trimethylene-bis(4-hydroxyiminomethylpyridinium)]] results in increased expression of TSPO protein]
CTD
PMID:33823148
NCBI chr 7:116,600,214...116,610,461
Ensembl chr 7:114,720,188...114,730,450
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Ttc14
tetratricopeptide repeat domain 14
decreases expression
EXP
Ketamine results in decreased expression of TTC14 mRNA
CTD
PMID:20080153
NCBI chr 2:118,581,779...118,600,361
Ensembl chr 2:116,653,595...116,664,158
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Ttc21b
tetratricopeptide repeat domain 21B
decreases expression
EXP
Ketamine results in decreased expression of TTC21B mRNA
CTD
PMID:20080153
NCBI chr 3:71,269,425...71,343,936
Ensembl chr 3:50,861,367...50,935,903
G
Ttll1
TTL family tubulin polyglutamylase complex subunit L1
decreases expression
EXP
Ketamine results in decreased expression of TTLL1 mRNA
CTD
PMID:20080153
NCBI chr 7:116,499,536...116,528,833
Ensembl chr 7:114,619,508...114,648,761
G
Ttll7
tubulin tyrosine ligase like 7
decreases expression
EXP
Ketamine results in decreased expression of TTLL7 mRNA
CTD
PMID:20080153
NCBI chr 2:238,425,786...238,549,296
Ensembl chr 2:235,765,835...235,885,047
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Ttr
transthyretin
multiple interactions
EXP
[ampullosporin co-treated with Ketamine] results in increased expression of TTR mRNA
CTD
PMID:16635253
NCBI chr18:12,216,684...12,225,972
Ensembl chr18:11,943,789...11,951,008
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Tuba1c
tubulin, alpha 1C
decreases expression
EXP
Ketamine results in decreased expression of TUBA1C protein
CTD
PMID:18504422
NCBI chr 7:131,636,974...132,078,589
Ensembl chr 7:130,192,016...130,199,647 Ensembl chr X:130,192,016...130,199,647
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Tuba4a
tubulin, alpha 4A
increases expression
EXP
Ketamine results in increased expression of TUBA4A mRNA
CTD
PMID:20080153
NCBI chr 9:84,158,871...84,174,041
Ensembl chr 9:76,709,614...76,713,918
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Twist1
twist family bHLH transcription factor 1
increases expression
ISO
Ketamine results in increased expression of TWIST1 mRNA
CTD
PMID:28331066
NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:50,674,678...50,677,653
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Txndc17
thioredoxin domain containing 17
decreases expression
EXP
Ketamine results in decreased expression of TXNDC17 mRNA
CTD
PMID:20080153
NCBI chr10:57,331,312...57,334,284
G
Txnip
thioredoxin interacting protein
increases expression
EXP
Ketamine results in increased expression of TXNIP mRNA
CTD
PMID:20080153
NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:184,092,991...184,096,886
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Tyms
thymidylate synthetase
decreases expression
EXP
Ketamine results in decreased expression of TYMS mRNA
CTD
PMID:20080153
NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:113,313,452...113,329,536
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U2surp
U2 snRNP-associated SURP domain containing
decreases expression
EXP
Ketamine results in decreased expression of U2SURP mRNA
CTD
PMID:20080153
NCBI chr 8:104,898,580...104,963,642
Ensembl chr 8:96,022,957...96,075,691
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Uap1
UDP-N-acetylglucosamine pyrophosphorylase 1
decreases expression
EXP
Ketamine results in decreased expression of UAP1 mRNA
CTD
PMID:20080153
NCBI chr13:84,875,719...84,910,706
Ensembl chr13:82,342,946...82,377,469 Ensembl chr 6:82,342,946...82,377,469
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Ubap1
ubiquitin-associated protein 1
decreases expression
EXP
Ketamine results in decreased expression of UBAP1 mRNA
CTD
PMID:20080153
NCBI chr 5:61,316,650...61,357,077
Ensembl chr 5:56,520,743...56,561,152
G
Ubap2
ubiquitin-associated protein 2
decreases expression
EXP
Ketamine results in decreased expression of UBAP2 mRNA
CTD
PMID:20080153
NCBI chr 5:61,144,182...61,233,355
Ensembl chr 5:56,348,246...56,437,049
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Ube2b
ubiquitin-conjugating enzyme E2B
increases expression
EXP
Ketamine results in increased expression of UBE2B mRNA
CTD
PMID:20080153
NCBI chr10:36,749,365...36,764,335
Ensembl chr10:36,248,438...36,264,665
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Ubqln1
ubiquilin 1
decreases expression
EXP
Ketamine results in decreased expression of UBQLN1 mRNA
CTD
PMID:20080153
NCBI chr17:6,438,456...6,482,498
Ensembl chr17:6,439,002...6,477,090
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Ugdh
UDP-glucose 6-dehydrogenase
decreases expression
EXP
Ketamine results in decreased expression of UGDH mRNA
CTD
PMID:20080153
NCBI chr14:43,202,480...43,226,002
Ensembl chr14:42,848,854...42,872,354
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Unc5c
unc-5 netrin receptor C
decreases expression
EXP
Ketamine results in decreased expression of UNC5C mRNA
CTD
PMID:20080153
NCBI chr 2:232,854,352...233,208,482
Ensembl chr 2:230,180,951...230,535,217
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Usp2
ubiquitin specific peptidase 2
increases expression
EXP
Ketamine results in increased expression of USP2 mRNA
CTD
PMID:20080153
NCBI chr 8:53,308,264...53,336,800
Ensembl chr 8:44,411,607...44,438,331
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Usp43
ubiquitin specific peptidase 43
decreases expression
EXP
Ketamine results in decreased expression of USP43 mRNA
CTD
PMID:20080153
NCBI chr10:52,549,200...52,611,168
Ensembl chr10:52,548,963...52,611,533
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Utp6
UTP6 small subunit processome component
decreases expression
EXP
Ketamine results in decreased expression of UTP6 mRNA
CTD
PMID:20080153
NCBI chr10:65,395,253...65,425,928
Ensembl chr10:64,897,328...64,927,997
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Vcam1
vascular cell adhesion molecule 1
multiple interactions
ISO
[Ketamine co-treated with Atropine] inhibits the reaction [Soman results in increased expression of VCAM1 mRNA]
CTD
PMID:22245128
NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958
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Vcan
versican
decreases expression
EXP
Ketamine results in decreased expression of VCAN mRNA
CTD
PMID:20080153
NCBI chr 2:22,497,035...22,595,955
Ensembl chr 2:20,761,718...20,860,637
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Vcpip1
valosin containing protein interacting protein 1
decreases expression
EXP
Ketamine results in decreased expression of VCPIP1 mRNA
CTD
PMID:20080153
NCBI chr 5:14,317,083...14,343,724
Ensembl chr 5:9,534,129...9,562,040
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Vdac2
voltage-dependent anion channel 2
increases expression
EXP
Ketamine results in increased expression of VDAC2 protein
CTD
PMID:18504422
NCBI chr15:2,512,214...2,526,105
Ensembl chr15:2,463,056...2,476,553
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Vim
vimentin
increases expression multiple interactions
ISO EXP
Ketamine results in increased expression of VIM mRNA 2-(5-benzo(1,3)dioxol-5-yl-2-tert-butyl-3H-imidazol-4-yl)-6-methylpyridine hydrochloride inhibits the reaction [Ketamine results in increased expression of VIM protein]
CTD
PMID:28331066 PMID:32153215
NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
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Vps13a
vacuolar protein sorting 13 homolog A
decreases expression
EXP
Ketamine results in decreased expression of VPS13A mRNA
CTD
PMID:20080153
NCBI chr 1:223,328,784...223,555,500
Ensembl chr 1:213,901,999...214,128,555
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Vps36
vacuolar protein sorting 36 homolog
decreases expression
EXP
Ketamine results in decreased expression of VPS36 mRNA
CTD
PMID:20080153
NCBI chr16:76,512,851...76,537,235
Ensembl chr16:69,808,193...69,834,810
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Washc3
WASH complex subunit 3
decreases expression
EXP
Ketamine results in decreased expression of WASHC3 mRNA
CTD
PMID:20080153
NCBI chr 7:24,508,544...24,553,012
Ensembl chr 7:22,621,078...22,690,696
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Wdr36
WD repeat domain 36
decreases expression
EXP
Ketamine results in decreased expression of WDR36 mRNA
CTD
PMID:20080153
NCBI chr18:24,747,812...24,783,704
Ensembl chr18:24,473,663...24,508,092
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Wdr47
WD repeat domain 47
decreases expression
EXP
Ketamine results in decreased expression of WDR47 mRNA
CTD
PMID:20080153
NCBI chr 2:198,914,977...198,975,844
Ensembl chr 2:196,205,238...196,287,739
G
Wfdc6a
WAP four-disulfide core domain 6A
increases expression
EXP
Ketamine results in increased expression of WFDC6A mRNA
CTD
PMID:20080153
NCBI chr 3:173,724,681...173,728,489
Ensembl chr 3:153,305,336...153,309,144
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Wfs1
wolframin ER transmembrane glycoprotein
increases expression
EXP
Ketamine results in increased expression of WFS1 mRNA
CTD
PMID:20080153
NCBI chr14:78,035,205...78,059,718
Ensembl chr14:73,810,404...73,835,602
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Wrn
WRN RecQ like helicase
decreases expression
EXP
Ketamine results in decreased expression of WRN mRNA
CTD
PMID:20080153
NCBI chr16:65,466,552...65,602,951
Ensembl chr16:58,763,504...58,895,450
G
Wtap
WT1 associated protein
increases expression
EXP
Ketamine results in increased expression of WTAP mRNA
CTD
PMID:20080153
NCBI chr 1:47,665,965...47,691,067
Ensembl chr 1:47,665,965...47,691,065
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Xbp1
X-box binding protein 1
multiple interactions
ISO
Ketamine affects the expression of and affects the splicing of XBP1 mRNA
CTD
PMID:35728656
NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693
G
Xylt2
xylosyltransferase 2
increases expression
EXP
Ketamine results in increased expression of XYLT2 mRNA
CTD
PMID:20080153
NCBI chr10:80,102,776...80,116,346
Ensembl chr10:79,606,007...79,619,391
G
Yars2
tyrosyl-tRNA synthetase 2
decreases expression
EXP
Ketamine results in decreased expression of YARS2 mRNA
CTD
PMID:20080153
NCBI chr11:98,136,530...98,142,320
Ensembl chr11:84,624,369...84,638,125
G
Ybx3
Y box binding protein 3
decreases expression
EXP
Ketamine results in decreased expression of YBX3 mRNA
CTD
PMID:20080153
NCBI chr 4:165,129,747...165,153,101
Ensembl chr 4:165,129,758...165,153,161
G
Yjefn3
YjeF N-terminal domain containing 3
increases expression
EXP
Ketamine results in increased expression of YJEFN3 mRNA
CTD
PMID:20080153
NCBI chr16:19,533,742...19,539,759
Ensembl chr16:19,533,788...19,539,728
G
Ypel5
yippee-like 5
increases expression
EXP
Ketamine results in increased expression of YPEL5 mRNA
CTD
PMID:20080153
NCBI chr 6:28,408,079...28,423,536
Ensembl chr 6:22,656,285...22,671,691
G
Yy1
YY1 transcription factor
decreases expression
EXP
Ketamine results in decreased expression of YY1 mRNA
CTD
PMID:20080153
NCBI chr 6:133,471,615...133,500,875
Ensembl chr 6:127,707,596...127,732,747
G
Zbed5
zinc finger BED-type containing 5
decreases expression
EXP
Ketamine results in decreased expression of ZBED5 mRNA
CTD
PMID:20080153
NCBI chr12:26,807,652...26,813,706
Ensembl chr12:26,807,600...26,813,664
G
Zbtb8b
zinc finger and BTB domain containing 8b
decreases expression
EXP
Ketamine results in decreased expression of ZBTB8B mRNA
CTD
PMID:20080153
NCBI chr 5:141,765,925...141,781,619
Ensembl chr 5:141,766,309...141,781,600
G
Zcchc9
zinc finger CCHC-type containing 9
decreases expression
EXP
Ketamine results in decreased expression of ZCCHC9 mRNA
CTD
PMID:20080153
NCBI chr 2:23,038,156...23,048,249
Ensembl chr 2:23,038,317...23,048,217
G
Zdhhc23
zinc finger DHHC-type palmitoyltransferase 23
decreases expression
EXP
Ketamine results in decreased expression of ZDHHC23 mRNA
CTD
PMID:20080153
NCBI chr11:56,718,702...56,735,063
Ensembl chr11:56,718,826...56,734,194
G
Zfand2a
zinc finger AN1-type containing 2A
increases expression
EXP
Ketamine results in increased expression of ZFAND2A mRNA
CTD
PMID:20080153
NCBI chr12:20,275,435...20,286,513
Ensembl chr12:15,161,639...15,172,677
G
Zfhx4
zinc finger homeobox 4
decreases expression
EXP
Ketamine results in decreased expression of ZFHX4 mRNA
CTD
PMID:20080153
NCBI chr 2:96,224,763...96,408,245
Ensembl chr 2:96,224,767...96,408,228
G
Zfp36
zinc finger protein 36
increases expression
EXP
Ketamine results in increased expression of ZFP36 mRNA
CTD
PMID:20080153
NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:83,669,084...83,671,564
G
Zfp524
zinc finger protein 524
decreases expression
EXP
Ketamine results in decreased expression of ZFP524 mRNA
CTD
PMID:20080153
NCBI chr 1:68,824,803...68,828,363
Ensembl chr 1:68,824,803...68,828,594
G
Zfp57
zinc finger protein 57
decreases expression
EXP
Ketamine results in decreased expression of ZFP57 mRNA
CTD
PMID:20080153
NCBI chr20:1,526,565...1,546,480
Ensembl chr20:1,521,323...1,529,846
G
Zfp638
zinc finger protein 638
decreases expression
EXP
Ketamine results in decreased expression of ZFP638 mRNA
CTD
PMID:20080153
NCBI chr 4:117,913,528...118,032,644
Ensembl chr 4:116,402,428...116,479,845
G
Zmynd8
zinc finger, MYND-type containing 8
decreases expression
EXP
Ketamine results in decreased expression of ZMYND8 mRNA
CTD
PMID:20080153
NCBI chr 3:174,948,162...175,061,382
Ensembl chr 3:154,529,043...154,628,463
G
Znf235-ps1
zinc finger protein 235, pseudogene 1
decreases expression
EXP
Ketamine results in decreased expression of ZFP61 mRNA
CTD
PMID:20080153
NCBI chr 1:79,799,766...79,808,543
Ensembl chr 1:79,799,769...79,808,465
G
Znhit6
zinc finger, HIT-type containing 6
decreases expression
EXP
Ketamine results in decreased expression of ZNHIT6 mRNA
CTD
PMID:20080153
NCBI chr 2:234,486,686...234,517,952
Ensembl chr 2:234,486,704...234,517,960
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Zswim5
zinc finger, SWIM-type containing 5
decreases expression
EXP
Ketamine results in decreased expression of ZSWIM5 mRNA
CTD
PMID:20080153
NCBI chr 5:135,583,356...135,700,390
Ensembl chr 5:130,343,034...130,463,784
G
Acaca
acetyl-CoA carboxylase alpha
multiple interactions
ISO
lactucin affects the reaction [Dietary Fats affects the expression of ACACA protein]
CTD
PMID:32023857
NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,014,170...69,276,457
G
Adam17
ADAM metallopeptidase domain 17
multiple interactions
ISO
lactucin inhibits the reaction [[[Palmitic Acid co-treated with Oleic Acid] results in increased abundance of Fatty Acids, Nonesterified] which results in increased expression of ADAM17 mRNA]; lactucin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of ADAM17 mRNA]
CTD
PMID:36055749
NCBI chr 6:46,601,583...46,663,690
Ensembl chr 6:40,872,856...40,920,639
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
ISO
lactucin results in increased expression of and results in decreased phosphorylation of AKT1 protein lactucin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]
CTD
PMID:33995112 PMID:36364182
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
G
Bax
BCL2 associated X, apoptosis regulator
increases expression
ISO
lactucin results in increased expression of BAX protein
CTD
PMID:36364182
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
multiple interactions decreases expression
ISO
Acetylcysteine inhibits the reaction [lactucin results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [lactucin results in decreased expression of BCL2 protein] lactucin results in decreased expression of BCL2 mRNA; lactucin results in decreased expression of BCL2 protein
CTD
PMID:34302634 PMID:36364182
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Casp3
caspase 3
increases cleavage
ISO
lactucin results in increased cleavage of CASP3 protein
CTD
PMID:34302634 PMID:36364182
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
G
Ccnb1
cyclin B1
decreases expression
ISO
lactucin results in decreased expression of CCNB1 protein
CTD
PMID:36364182
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
G
Ccnd1
cyclin D1
decreases expression
ISO
lactucin results in decreased expression of CCND1 protein
CTD
PMID:36364182
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
G
Cd36
CD36 molecule
multiple interactions
ISO
lactucin affects the reaction [Dietary Fats affects the expression of CD36 mRNA]
CTD
PMID:32023857
NCBI chr 4:18,209,088...18,302,142
Ensembl chr 4:17,354,466...17,513,903
G
Cdk2
cyclin dependent kinase 2
decreases expression
ISO
lactucin results in decreased expression of CDK2 protein
CTD
PMID:36364182
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
G
Cdk4
cyclin-dependent kinase 4
decreases expression
ISO
lactucin results in decreased expression of CDK4 protein
CTD
PMID:36364182
NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression
ISO
lactucin results in increased expression of CDKN1A protein
CTD
PMID:36364182
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
G
Cebpa
CCAAT/enhancer binding protein alpha
multiple interactions
ISO
lactucin affects the reaction [Dietary Fats affects the expression of CEBPA mRNA]; lactucin affects the reaction [Dietary Fats affects the expression of CEBPA protein]
CTD
PMID:32023857
NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412
G
Cebpb
CCAAT/enhancer binding protein beta
multiple interactions
ISO
lactucin affects the reaction [Dietary Fats affects the expression of CEBPB protein]
CTD
PMID:32023857
NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473
G
Cflar
CASP8 and FADD-like apoptosis regulator
multiple interactions
ISO
Acetylcysteine inhibits the reaction [lactucin results in decreased expression of CFLAR protein]; CFLAR protein inhibits the reaction [lactucin results in increased cleavage of PARP1 protein]; lactucin results in decreased expression of and results in increased degradation of CFLAR protein
CTD
PMID:34302634
NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034
G
Dgat1
diacylglycerol O-acyltransferase 1
multiple interactions
ISO
lactucin affects the reaction [Dietary Fats affects the expression of DGAT1 mRNA]
CTD
PMID:32023857
NCBI chr 7:110,104,514...110,119,091
Ensembl chr 7:108,218,524...108,234,299
G
Fas
Fas cell surface death receptor
multiple interactions
ISO
lactucin affects the reaction [Dietary Fats affects the expression of FAS protein]
CTD
PMID:32023857
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
G
Gpt
glutamic--pyruvic transaminase
multiple interactions
ISO
lactucin affects the reaction [Dietary Fats affects the activity of GPT protein]
CTD
PMID:32023857
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
G
Hadha
hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
multiple interactions
ISO
lactucin inhibits the reaction [[[Palmitic Acid co-treated with Oleic Acid] results in increased abundance of Fatty Acids, Nonesterified] which results in decreased expression of HADHA mRNA]; lactucin inhibits the reaction [[[Palmitic Acid co-treated with Oleic Acid] results in increased abundance of Fatty Acids, Nonesterified] which results in decreased expression of HADHA protein]; lactucin inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of HADHA mRNA]; lactucin inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of HADHA protein]
CTD
PMID:36055749
NCBI chr 6:31,907,801...31,947,434
Ensembl chr 6:26,187,956...26,227,869
G
Il1b
interleukin 1 beta
multiple interactions
ISO
lactucin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL1B protein]; lactucin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD
PMID:33995112 PMID:39164375
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
ISO
lactucin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; lactucin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
CTD
PMID:33995112 PMID:39164375
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
G
Jak2
Janus kinase 2
multiple interactions
ISO
lactucin affects the reaction [Dietary Fats affects the phosphorylation of JAK2 protein]
CTD
PMID:32023857
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
G
Ldha
lactate dehydrogenase A
affects binding
ISO
lactucin binds to LDHA protein
CTD
PMID:36364182
NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472
G
Map1lc3b
microtubule-associated protein 1 light chain 3 beta
multiple interactions
ISO
lactucin results in increased expression of and results in increased lipidation of MAP1LC3B protein
CTD
PMID:36364182
NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
lactucin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] lactucin results in increased expression of and results in decreased phosphorylation of MAPK1 protein
CTD
PMID:33995112 PMID:36364182
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
lactucin results in increased expression of and results in decreased phosphorylation of MAPK3 protein lactucin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
CTD
PMID:33995112 PMID:36364182
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
G
Nos2
nitric oxide synthase 2
multiple interactions
ISO
lactucin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; lactucin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD
PMID:33995112
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage multiple interactions
ISO
lactucin results in increased cleavage of PARP1 protein benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [lactucin results in increased cleavage of PARP1 protein]; CFLAR protein inhibits the reaction [lactucin results in increased cleavage of PARP1 protein]
CTD
PMID:34302634 PMID:36364182
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
G
Pgm1
phosphoglucomutase 1
affects binding
ISO
lactucin binds to PGM1 protein
CTD
PMID:36364182
NCBI chr 5:119,710,734...119,770,159
Ensembl chr 5:114,595,293...114,654,728
G
Pkm
pyruvate kinase M1/2
affects binding
ISO
lactucin binds to PKM protein
CTD
PMID:36364182
NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:60,057,402...60,079,599
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions
ISO
lactucin affects the reaction [Dietary Fats affects the expression of PPARG mRNA]; lactucin affects the reaction [Dietary Fats affects the expression of PPARG protein]
CTD
PMID:32023857
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
G
Pten
phosphatase and tensin homolog
increases expression
ISO
lactucin results in increased expression of PTEN protein
CTD
PMID:36364182
NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
lactucin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; lactucin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]
CTD
PMID:33995112
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
G
Smad3
SMAD family member 3
decreases expression
ISO EXP
lactucin results in decreased expression of SMAD3 protein
CTD
PMID:39164375
NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960
G
Smad7
SMAD family member 7
increases expression
EXP ISO
lactucin results in increased expression of SMAD7 protein
CTD
PMID:39164375
NCBI chr18:71,263,508...71,291,849
Ensembl chr18:68,988,429...69,016,765
G
Sqstm1
sequestosome 1
multiple interactions
ISO
lactucin inhibits the reaction [[[Palmitic Acid co-treated with Oleic Acid] results in increased abundance of Fatty Acids, Nonesterified] which results in increased expression of SQSTM1 mRNA]; lactucin inhibits the reaction [Fatty Acids, Nonesterified results in increased expression of SQSTM1 mRNA]
CTD
PMID:36055749
NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673
G
Stat3
signal transducer and activator of transcription 3
multiple interactions decreases localization
ISO EXP
lactucin affects the reaction [Dietary Fats affects the phosphorylation of STAT3 protein] lactucin results in decreased localization of STAT3 protein; lactucin results in decreased localization of STAT3 protein modified form
CTD
PMID:32023857 PMID:39164375
NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
G
Tgfb1
transforming growth factor, beta 1
decreases expression
EXP ISO
lactucin results in decreased expression of TGFB1 protein
CTD
PMID:39164375
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
G
Tlr4
toll-like receptor 4
increases expression
EXP
lactucin results in increased expression of TLR4 protein
CTD
PMID:39164375
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
G
Tnf
tumor necrosis factor
multiple interactions
ISO
lactucin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
CTD
PMID:39164375
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Tp53
tumor protein p53
increases expression
ISO
lactucin results in increased expression of TP53 protein
CTD
PMID:36364182
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
G
Acta2
actin alpha 2, smooth muscle
multiple interactions
EXP
limonene inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]
CTD
PMID:29251412
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
G
Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
[carvone co-treated with limonene] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]
CTD
PMID:29191726
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
G
Akr1d1
aldo-keto reductase family 1, member D1
decreases expression
EXP
limonene results in decreased expression of AKR1D1 mRNA
CTD
PMID:12815608
NCBI chr 4:67,121,288...67,154,543
Ensembl chr 4:66,154,248...66,186,372
G
Alb
albumin
increases expression multiple interactions
EXP
limonene results in increased expression of ALB protein limonene inhibits the reaction [Carbon Tetrachloride results in decreased secretion of ALB protein]
CTD
PMID:23159986 PMID:29251412
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
G
Arg1
arginase 1
increases expression
EXP
limonene results in increased expression of ARG1 mRNA
CTD
PMID:12815608
NCBI chr 1:22,295,093...22,307,720
Ensembl chr 1:20,475,968...20,488,422
G
Atf3
activating transcription factor 3
increases expression
ISO
limonene results in increased expression of ATF3 mRNA
CTD
PMID:27965148
NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631
G
Atp1a1
ATPase Na+/K+ transporting subunit alpha 1
increases expression
EXP
limonene results in increased expression of ATP1A1 mRNA
CTD
PMID:12815608
NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:189,020,722...189,048,837
G
Bcl2
BCL2, apoptosis regulator
decreases expression
ISO
limonene results in decreased expression of BCL2 protein
CTD
PMID:12921557
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Calm1
calmodulin 1
increases expression
EXP
limonene results in increased expression of CALM1 mRNA
CTD
PMID:12815608
NCBI chr 6:125,217,191...125,227,855
Ensembl chr 6:119,487,621...119,498,227
G
Cat
catalase
multiple interactions
EXP
limonene inhibits the reaction [Carbon Tetrachloride results in decreased activity of CAT protein]
CTD
PMID:29251412
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
G
Ccng1
cyclin G1
increases expression
EXP
limonene results in increased expression of CCNG1 mRNA
CTD
PMID:12815608
NCBI chr10:25,678,503...25,684,876
Ensembl chr10:25,176,234...25,181,641
G
Cdk1
cyclin-dependent kinase 1
increases expression
EXP
limonene results in increased expression of CDK1 mRNA
CTD
PMID:12815608
NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408
G
Col3a1
collagen type III alpha 1 chain
increases expression
EXP
limonene results in increased expression of COL3A1 mRNA
CTD
PMID:12815608
NCBI chr 9:54,866,646...54,902,578
Ensembl chr 9:47,374,593...47,410,547
G
Cox4i1
cytochrome c oxidase subunit 4i1
increases expression
EXP
limonene results in increased expression of COX4I1 mRNA
CTD
PMID:12815608
NCBI chr19:65,630,383...65,636,623
Ensembl chr19:48,721,199...48,727,921
G
Cox5a
cytochrome c oxidase subunit 5A
increases expression
EXP
limonene results in increased expression of COX5A mRNA
CTD
PMID:12815608
NCBI chr 8:66,818,284...66,829,691
Ensembl chr 8:57,922,290...57,933,781
G
Cox6c
cytochrome c oxidase subunit 6C
decreases expression
EXP
limonene results in decreased expression of COX6C mRNA
CTD
PMID:12815608
NCBI chr 7:69,014,410...69,027,145
Ensembl chr 7:67,111,024...67,141,963
G
Ctsd
cathepsin D
increases expression multiple interactions
ISO
Limonene results in increased expression of CTSD mRNA Fulvestrant inhibits the reaction [Limonene results in increased expression of CTSD mRNA]
CTD
PMID:31393563
NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488
G
Cyb5a
cytochrome b5 type A
increases expression
EXP
limonene results in increased expression of CYB5A mRNA
CTD
PMID:12815608
NCBI chr18:80,487,923...80,520,544
Ensembl chr18:78,202,342...78,258,535 Ensembl chr18:78,202,342...78,258,535
G
Cycs
cytochrome c, somatic
increases expression
EXP
limonene results in increased expression of CYCS mRNA
CTD
PMID:12815608
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
G
Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
increases expression
ISO
limonene results in increased expression of CYP1A1 mRNA
CTD
PMID:20491607
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
G
Cyp2b1
cytochrome P450, family 2, subfamily b, polypeptide 1
decreases activity
EXP
limonene results in decreased activity of CYP2B1 protein
CTD
PMID:9242356
NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052
G
Cyp2b12
cytochrome P450, family 2, subfamily b, polypeptide 12
increases expression
EXP
limonene results in increased expression of CYP2B12 mRNA
CTD
PMID:12815608
NCBI chr 1:91,135,294...91,147,094
Ensembl chr 1:82,007,609...82,080,480
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
multiple interactions
ISO
Limonene inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Midazolam]
CTD
PMID:18385293
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
G
Cyp4f6
cytochrome P450, family 4, subfamily f, polypeptide 6
multiple interactions
ISO
Limonene inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA]
CTD
PMID:31393563
NCBI chr 7:12,680,799...12,708,378
Ensembl chr 7:12,030,301...12,057,782
G
Cyp51
cytochrome P450, family 51
increases expression
EXP
limonene results in increased expression of CYP51 mRNA
CTD
PMID:12815608
NCBI chr 4:30,991,693...31,010,147
Ensembl chr 4:30,036,865...30,055,410 Ensembl chr 6:30,036,865...30,055,410
G
Decr1
2,4-dienoyl-CoA reductase 1
increases expression
EXP
limonene results in increased expression of DECR1 mRNA
CTD
PMID:12815608
NCBI chr 5:34,208,195...34,236,074
Ensembl chr 5:29,411,172...29,439,018
G
Dnaja2
DnaJ heat shock protein family (Hsp40) member A2
increases expression
EXP
limonene results in increased expression of DNAJA2 mRNA
CTD
PMID:12815608
NCBI chr19:37,671,019...37,689,163
Ensembl chr19:21,497,729...21,516,901
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Dut
deoxyuridine triphosphatase
increases expression
EXP
limonene results in increased expression of DUT mRNA
CTD
PMID:12815608
NCBI chr 3:132,952,258...132,963,433
Ensembl chr 3:112,498,982...112,510,771
G
Gadd45a
growth arrest and DNA-damage-inducible, alpha
increases expression
EXP
limonene results in increased expression of GADD45A mRNA
CTD
PMID:12815608
NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115
G
Gclm
glutamate cysteine ligase, modifier subunit
increases expression
ISO
limonene results in increased expression of GCLM mRNA
CTD
PMID:27965148
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535
G
Gjb2
gap junction protein, beta 2
increases expression
EXP
limonene results in increased expression of GJB2 mRNA
CTD
PMID:12815608
NCBI chr15:35,375,977...35,393,817
Ensembl chr15:31,260,357...31,278,177
G
Glo1
glyoxalase 1
multiple interactions
ISO
limonene inhibits the reaction [Pyruvaldehyde results in decreased activity of GLO1 protein]
CTD
PMID:28986142
NCBI chr20:8,665,061...8,683,095
Ensembl chr20:8,662,801...8,681,649
G
Gna15
G protein subunit alpha 15
increases response to substance multiple interactions
ISO
GNA15 protein results in increased susceptibility to limonene [GNA15 protein results in increased susceptibility to Limonene] which results in increased activity of OR2V1 protein
CTD
PMID:9875846
NCBI chr 7:8,835,396...8,856,269
Ensembl chr 7:8,184,861...8,205,508
G
Gpx1
glutathione peroxidase 1
increases expression
EXP
limonene results in increased expression of GPX1 mRNA
CTD
PMID:12815608
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
G
Gpx4
glutathione peroxidase 4
increases expression
EXP
limonene results in increased expression of GPX4 mRNA
CTD
PMID:12815608
NCBI chr 7:10,300,833...10,303,629
Ensembl chr 7:9,650,185...9,652,982
G
Greb1
growth regulating estrogen receptor binding 1
increases expression multiple interactions
ISO
Limonene results in increased expression of GREB1 mRNA Fulvestrant inhibits the reaction [Limonene results in increased expression of GREB1 mRNA]
CTD
PMID:31393563
NCBI chr 6:45,169,289...45,321,973
Ensembl chr 6:39,440,504...39,581,633
G
Grpel1
GrpE-like 1, mitochondrial
increases expression
EXP
limonene results in increased expression of GRPEL1 mRNA
CTD
PMID:12815608
NCBI chr14:78,517,049...78,522,868
Ensembl chr14:74,292,023...74,298,200
G
Gstm1
glutathione S-transferase mu 1
increases expression
EXP
limonene results in increased expression of GSTM1 protein
CTD
PMID:23159986
NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411
G
Gstm5l
glutathione S-transferase, mu 5-like
increases expression
EXP
Limonene results in increased expression of GSTM5 mRNA
CTD
PMID:12815608
NCBI chr 2:198,231,285...198,238,122
Ensembl chr 2:195,544,426...195,628,961
G
Hmox1
heme oxygenase 1
increases expression multiple interactions
ISO
limonene results in increased expression of HMOX1 mRNA limonene inhibits the reaction [Pyruvaldehyde results in decreased expression of HMOX1 protein]
CTD
PMID:20491607 PMID:28986142
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
G
Hras
HRas proto-oncogene, GTPase
multiple interactions
ISO
limonene inhibits the reaction [HRAS protein results in increased susceptibility to Methylnitrosourea]
CTD
PMID:11802805
NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615
G
Hsp90ab1
heat shock protein 90 alpha family class B member 1
increases expression
EXP
limonene results in increased expression of HSP90AB1 mRNA
CTD
PMID:12815608
NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:15,433,691...15,438,488
G
Hspd1
heat shock protein family D (Hsp60) member 1
increases expression
EXP
limonene results in increased expression of HSPD1 mRNA
CTD
PMID:12815608
NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:56,579,201...56,589,662
G
Il1a
interleukin 1 alpha
affects expression
ISO
Limonene affects the expression of IL1A protein
CTD
PMID:19878710
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
G
Il6
interleukin 6
multiple interactions
ISO
limonene inhibits the reaction [Pyruvaldehyde results in increased secretion of IL6 protein]
CTD
PMID:28986142
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
multiple interactions
ISO
limonene inhibits the reaction [Diethylnitrosamine results in increased expression of JUN protein]
CTD
PMID:10425313
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
G
Lif
LIF, interleukin 6 family cytokine
affects expression
ISO
Limonene affects the expression of LIF protein
CTD
PMID:19878710
NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482
G
Mapk14
mitogen activated protein kinase 14
increases expression
EXP
limonene results in increased expression of MAPK14 mRNA
CTD
PMID:12815608
NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589
G
Mapk6
mitogen-activated protein kinase 6
increases expression
EXP
limonene results in increased expression of MAPK6 mRNA
CTD
PMID:12815608
NCBI chr 8:85,027,141...85,050,236
Ensembl chr 8:76,146,690...76,169,720
G
Mgat2
alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
increases expression
EXP
limonene results in increased expression of MGAT2 mRNA
CTD
PMID:12815608
NCBI chr 6:93,392,416...93,394,905
Ensembl chr 6:87,656,349...87,658,177
G
Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions increases expression
ISO EXP
limonene inhibits the reaction [Diethylnitrosamine results in increased expression of MYC protein] limonene results in increased expression of MYC mRNA
CTD
PMID:10425313 PMID:12815608
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
G
Nfkb1
nuclear factor kappa B subunit 1
increases expression
EXP
limonene results in increased expression of NFKB1 mRNA
CTD
PMID:12815608
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
G
Npy
neuropeptide Y
decreases expression
ISO EXP
limonene results in decreased expression of NPY protein limonene results in decreased expression of NPY mRNA
CTD
PMID:22757684
NCBI chr 4:80,212,111...80,219,310
Ensembl chr 4:78,881,264...78,888,495
G
Obp3
alpha-2u globulin PGCL4
affects binding increases expression
EXP
limonene binds to OBP3 protein limonene results in increased expression of OBP3 protein
CTD
PMID:19428932 PMID:20069279
NCBI chr 5:74,842,316...74,845,858
Ensembl chr 5:74,842,316...74,845,757
G
Or2v1
olfactory receptor family 2 subfamily V member 1
increases activity multiple interactions
ISO
Limonene results in increased activity of OR2V1 protein [GNA15 protein results in increased susceptibility to Limonene] which results in increased activity of OR2V1 protein
CTD
PMID:9875846
NCBI chr10:33,901,067...33,905,416
Ensembl chr10:33,398,913...33,404,401
G
Pcna
proliferating cell nuclear antigen
increases expression
EXP
limonene results in increased expression of PCNA mRNA
CTD
PMID:12815608
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
G
Pdia3
protein disulfide isomerase family A, member 3
increases expression
EXP
limonene results in increased expression of PDIA3 mRNA
CTD
PMID:12815608
NCBI chr 3:128,841,781...128,865,733
Ensembl chr 3:108,388,245...108,413,236
G
Pgr
progesterone receptor
multiple interactions increases expression
ISO
Fulvestrant inhibits the reaction [Limonene results in increased expression of PGR mRNA]
CTD
PMID:31393563
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
G
Ppargc1a
PPARG coactivator 1 alpha
multiple interactions
ISO
[limonene co-treated with Pyruvaldehyde] results in increased expression of PPARGC1A protein
CTD
PMID:28986142
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
G
Ppia
peptidylprolyl isomerase A
increases expression
EXP
limonene results in increased expression of PPIA mRNA
CTD
PMID:12815608
NCBI chr14:85,491,223...85,496,884
Ensembl chr14:81,275,091...81,299,601
G
Ppib
peptidylprolyl isomerase B
increases expression
EXP
limonene results in increased expression of PPIB mRNA
CTD
PMID:12815608
NCBI chr 8:75,498,966...75,504,823
Ensembl chr 8:66,603,861...66,630,428
G
Rara
retinoic acid receptor, alpha
decreases expression
EXP
limonene results in decreased expression of RARA mRNA
CTD
PMID:12815608
NCBI chr10:84,379,780...84,424,371
Ensembl chr10:83,893,384...83,928,142
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
limonene inhibits the reaction [Carbon Tetrachloride results in increased expression of RELA protein]
CTD
PMID:29251412
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
G
Scd
stearoyl-CoA desaturase
increases expression
EXP
limonene results in increased expression of SCD1 mRNA
CTD
PMID:12815608
NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
G
Scn5a
sodium voltage-gated channel alpha subunit 5
multiple interactions
ISO
limonene inhibits the reaction [2,3,5,6-tetrafluoro-4-methylbenzyl (Z)-(1RS)-cis-3-(2-chloro-3,3,3-trifluoroprop-1-enyl)-2,2-dimethylcyclopropanecarboxylate results in increased activity of SCN5A protein]
CTD
PMID:29306026
NCBI chr 8:128,098,613...128,196,515
Ensembl chr 8:119,220,905...119,318,769
G
Sec14l2
SEC14-like lipid binding 2
multiple interactions
ISO
Limonene inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA]
CTD
PMID:31393563
NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788
G
Sod1
superoxide dismutase 1
decreases expression
EXP
limonene results in decreased expression of SOD1 mRNA
CTD
PMID:12815608
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
G
Tgfa
transforming growth factor alpha
increases expression
EXP
limonene results in increased expression of TGFA mRNA
CTD
PMID:12815608
NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:118,618,269...118,700,894
G
Tgfb1
transforming growth factor, beta 1
multiple interactions
EXP
limonene inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]
CTD
PMID:29251412
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
G
Tnf
tumor necrosis factor
multiple interactions
ISO EXP
limonene inhibits the reaction [Pyruvaldehyde results in increased secretion of TNF protein] limonene inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]
CTD
PMID:28986142 PMID:29251412
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Tp53
tumor protein p53
increases expression
ISO
limonene results in increased expression of TP53 protein
CTD
PMID:12921557
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
G
Vip
vasoactive intestinal peptide
increases expression
EXP
limonene results in increased expression of VIP protein
CTD
PMID:20934418
NCBI chr 1:44,470,232...44,478,561
Ensembl chr 1:42,065,120...42,073,216
G
Cldn1
claudin 1
increases expression
ISO
loxoprofen metabolite results in increased expression of CLDN1 protein; loxoprofen results in increased expression of CLDN1 mRNA; loxoprofen results in increased expression of CLDN1 protein
CTD
PMID:34506768
NCBI chr11:87,926,376...87,941,533
Ensembl chr11:74,421,569...74,436,724
G
Cldn3
claudin 3
increases expression
ISO
loxoprofen metabolite results in increased expression of CLDN3 protein; loxoprofen results in increased expression of CLDN3 mRNA; loxoprofen results in increased expression of CLDN3 protein
CTD
PMID:34506768
NCBI chr12:27,345,075...27,346,547
Ensembl chr12:21,708,398...21,711,001
G
Cldn5
claudin 5
increases expression
ISO
loxoprofen metabolite results in increased expression of CLDN5 protein; loxoprofen results in increased expression of CLDN5 mRNA; loxoprofen results in increased expression of CLDN5 protein
CTD
PMID:34506768
NCBI chr11:95,717,172...95,718,598
Ensembl chr11:82,211,475...82,214,992
G
Mapk1
mitogen activated protein kinase 1
decreases phosphorylation
ISO
loxoprofen metabolite results in decreased phosphorylation of MAPK1 protein; loxoprofen results in decreased phosphorylation of MAPK1 protein
CTD
PMID:34506768
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
decreases phosphorylation
ISO
loxoprofen metabolite results in decreased phosphorylation of MAPK3 protein; loxoprofen results in decreased phosphorylation of MAPK3 protein
CTD
PMID:34506768
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
G
Mpo
myeloperoxidase
increases activity
EXP
loxoprofen results in increased activity of MPO protein
CTD
PMID:20586851
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
G
Muc2
mucin 2, oligomeric mucus/gel-forming
multiple interactions decreases expression
EXP
lafutidine inhibits the reaction [loxoprofen results in decreased expression of MUC2]
CTD
PMID:20586851
NCBI chr 1:206,225,775...206,261,280
Ensembl chr 1:196,799,517...196,831,756
G
Nos2
nitric oxide synthase 2
increases expression multiple interactions
EXP
loxoprofen results in increased expression of NOS2 lafutidine inhibits the reaction [loxoprofen results in increased expression of NOS2]
CTD
PMID:20586851
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
G
Hmox1
heme oxygenase 1
increases expression
ISO
lucidenic acid N analog results in increased expression of HMOX1 protein
CTD
PMID:25239868
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
G
Bax
BCL2 associated X, apoptosis regulator
affects expression
ISO
lupulon affects the expression of BAX protein
CTD
PMID:17434926
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
affects expression
ISO
lupulon affects the expression of BCL2 protein
CTD
PMID:17434926
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Fas
Fas cell surface death receptor
increases expression
ISO
lupulon results in increased expression of FAS protein
CTD
PMID:17434926
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
G
Faslg
Fas ligand
increases expression
ISO
lupulon results in increased expression of FASLG protein
CTD
PMID:17434926
NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
G
Tnfrsf10b
TNF receptor superfamily member 10b
increases expression
ISO
lupulon results in increased expression of TNFRSF10A protein
CTD
PMID:17434926
NCBI chr15:51,249,883...51,278,091
Ensembl chr15:44,840,386...44,867,467
G
Gclc
glutamate-cysteine ligase, catalytic subunit
multiple interactions
ISO
[nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA
CTD
PMID:12899938
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
multiple interactions
ISO
[nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLM mRNA
CTD
PMID:12899938
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535
G
Hmox1
heme oxygenase 1
multiple interactions
ISO
[nitisinone results in decreased activity of HPD protein] which results in decreased expression of HMOX1 mRNA
CTD
PMID:12899938
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
G
Hpd
4-hydroxyphenylpyruvate dioxygenase
multiple interactions
ISO
[nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLC mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of GCLM mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of HMOX1 mRNA; [nitisinone results in decreased activity of HPD protein] which results in decreased expression of NQO1 mRNA
CTD
PMID:12899938
NCBI chr12:39,042,246...39,053,596
Ensembl chr12:33,381,231...33,392,766
G
Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
ISO
[nitisinone results in decreased activity of HPD protein] which results in decreased expression of NQO1 mRNA
CTD
PMID:12899938
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
G
Adipoq
adiponectin, C1Q and collagen domain containing
multiple interactions
ISO
omaveloxolone analog inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of ADIPOQ protein]
CTD
PMID:32410268
NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564
G
Fth1
ferritin heavy chain 1
multiple interactions
ISO
omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FTH1 mRNA]; omaveloxolone promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of FTH1 mRNA]
CTD
PMID:32410268
NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424
G
Gpt
glutamic--pyruvic transaminase
multiple interactions
ISO
[omaveloxolone analog co-treated with Streptozocin co-treated with Dietary Fats] results in increased expression of GPT protein
CTD
PMID:32410268
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
G
Lep
leptin
multiple interactions
ISO
omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of LEP protein]
CTD
PMID:32410268
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
G
Nqo1
NAD(P)H quinone dehydrogenase 1
multiple interactions
ISO
[omaveloxolone analog co-treated with Streptozocin co-treated with Dietary Fats] results in increased activity of NQO1 protein; [omaveloxolone co-treated with Streptozocin co-treated with Dietary Fats] results in increased activity of NQO1 protein; omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NQO1 mRNA]; omaveloxolone promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NQO1 mRNA]
CTD
PMID:32410268
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
G
Srxn1
sulfiredoxin 1
multiple interactions
ISO
omaveloxolone analog promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of SRXN1 mRNA]; omaveloxolone promotes the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of SRXN1 mRNA]
CTD
PMID:32410268
NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:140,599,608...140,628,448
G
Akt1
AKT serine/threonine kinase 1
increases phosphorylation
ISO
Perillyl alcohol increases phosphorylation of AKT1 protein in DU145 prostate gland cancer cells
RGD
PMID:17601486
RGD:408364950
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
G
Bak1
BCL2-antagonist/killer 1
increases expression
ISO
perillyl alcohol results in increased expression of BAK1 protein
CTD
PMID:12530055
NCBI chr20:5,102,334...5,111,615
Ensembl chr20:5,100,480...5,109,264
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of BAX protein]
CTD
PMID:19161993
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein]
CTD
PMID:19161993
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Cat
catalase
multiple interactions
ISO EXP
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein] perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of CAT protein]
CTD
PMID:19161993 PMID:20923693
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
G
Ccna2
cyclin A2
decreases expression
ISO
perillyl alcohol results in decreased expression of CCNA2 protein
CTD
PMID:17138864
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
G
Ccnb1
cyclin B1
decreases expression
ISO
perillyl alcohol results in decreased expression of CCNB1 protein
CTD
PMID:17138864
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
G
Cdk2
cyclin dependent kinase 2
decreases expression multiple interactions
ISO
perillyl alcohol results in decreased expression of CDK2 protein perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
CTD
PMID:17138864
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
G
Cdkn1a
cyclin-dependent kinase inhibitor 1A
increases expression multiple interactions increases response to substance
ISO
perillyl alcohol results in increased expression of CDKN1A protein perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein] CDKN1A protein results in increased susceptibility to perillyl alcohol
CTD
PMID:17138864
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
G
Cdkn1b
cyclin-dependent kinase inhibitor 1B
increases expression increases response to substance multiple interactions
ISO
perillyl alcohol results in increased expression of CDKN1B protein CDKN1B protein results in increased susceptibility to perillyl alcohol perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
CTD
PMID:17138864
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
G
Fbxo32
F-box protein 32
increases expression
ISO
perillyl alcohol results in increased expression of FBXO32 mRNA; perillyl alcohol results in increased expression of FBXO32 protein
CTD
PMID:19406843
NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:89,730,232...89,765,436
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Fnta
farnesyltransferase, CAAX box, subunit alpha
multiple interactions
EXP
[Vitamin A co-treated with perillyl alcohol] results in decreased expression of FNTA protein
CTD
PMID:15959631
NCBI chr16:72,767,864...72,786,193
Ensembl chr16:66,065,132...66,083,460
G
Fntb
farnesyltransferase, CAAX box, subunit beta
multiple interactions increases expression decreases expression
EXP
[perillyl alcohol co-treated with Vitamin A] results in decreased expression of FNTB mRNA perillyl alcohol results in increased expression of FNTB protein perillyl alcohol results in decreased expression of FNTB mRNA
CTD
PMID:15959631
NCBI chr 6:101,269,657...101,352,716
Ensembl chr 6:95,470,683...95,619,586
G
Gsr
glutathione-disulfide reductase
multiple interactions
ISO EXP
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GSR protein] perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of GSR protein]
CTD
PMID:19161993 PMID:20923693
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
G
H6pd
hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)
multiple interactions
EXP
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of H6PD protein]
CTD
PMID:20923693
NCBI chr 5:165,717,456...165,753,158
Ensembl chr 5:160,438,697...160,470,171
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Ivl
involucrin
decreases expression
ISO
perillyl alcohol results in decreased expression of IVL protein
CTD
PMID:10769631
NCBI chr 2:180,842,307...180,854,646
Ensembl chr 2:178,147,061...178,149,100
G
Mapk1
mitogen activated protein kinase 1
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
CTD
PMID:19161993
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
CTD
PMID:19161993
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
G
Odc1
ornithine decarboxylase 1
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein]
CTD
PMID:19161993
NCBI chr 6:46,058,439...46,065,148
Ensembl chr 6:40,329,964...40,336,440
G
Raf1
Raf-1 proto-oncogene, serine/threonine kinase
multiple interactions
ISO
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RAF1 protein]
CTD
PMID:19161993
NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317
G
Rap1a
RAP1A, member of RAS oncogene family
multiple interactions increases expression
ISO
Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RAP1A protein]
CTD
PMID:12671036
NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:193,208,635...193,286,501
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
perillyl alcohol inhibits the reaction [Ethanol results in increased activity of RELA protein]
CTD
PMID:20923693
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
G
Rhoa
ras homolog family member A
multiple interactions increases expression
ISO EXP
Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOA protein] [perillyl alcohol co-treated with Vitamin A] results in increased expression of RHOA mRNA
CTD
PMID:12671036 PMID:15959631
NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746
G
Rhob
ras homolog family member B
increases expression multiple interactions
ISO EXP
perillyl alcohol results in increased expression of RHOB protein [perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB mRNA; [perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB protein Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOB protein] perillyl alcohol results in increased expression of RHOB mRNA; perillyl alcohol results in increased expression of RHOB protein
CTD
PMID:12671036 PMID:15959631
NCBI chr 6:37,083,030...37,085,204
Ensembl chr 6:31,363,548...31,366,108
G
Tnf
tumor necrosis factor
multiple interactions
EXP
perillyl alcohol inhibits the reaction [Ethanol results in increased expression of TNF protein]
CTD
PMID:20923693
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
EXP ISO
plerixafor inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein] plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]
CTD
PMID:18660423 PMID:29510123
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
G
Cdh1
cadherin 1
increases expression multiple interactions
ISO
plerixafor increases expression of CDH1 protein in lymph node and prostate epithelium plerixafor inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]; plerixafor inhibits the reaction [Estradiol results in decreased expression of CDH1 protein]; plerixafor inhibits the reaction [Triclosan results in decreased expression of CDH1 protein]
CTD RGD
PMID:28844962 PMID:30537000
RGD:152025215
NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
G
Cdh2
cadherin 2
decreases expression
ISO
plerixafor decreases expression of CDH2 protein in lymph node and prostate epithelium
RGD
PMID:30537000
RGD:152025215
NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167
G
Cxcl12
C-X-C motif chemokine ligand 12
decreases expression multiple interactions
ISO
plerixafor results in decreased expression of CXCL12 mRNA plerixafor inhibits the reaction [CXCL12 protein affects the localization of CXCR4 protein]; plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of AKT1 protein]; plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein]
CTD
PMID:12220670 PMID:18660423 PMID:24157575
NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:150,388,325...150,401,168
G
Cxcr4
C-X-C motif chemokine receptor 4
decreases expression multiple interactions decreases activity decreases phosphorylation
EXP ISO
Plerixafor decreases expression of CXCR4 protein in liver plerixafor binds to and results in decreased activity of CXCR4 protein; plerixafor inhibits the reaction [bisphenol A results in increased expression of CXCR4 protein]; plerixafor inhibits the reaction [CXCL12 protein affects the localization of CXCR4 protein]; plerixafor inhibits the reaction [Estradiol results in increased expression of CXCR4 protein]; plerixafor inhibits the reaction [Triclosan results in increased expression of CXCR4 protein] plerixafor results in decreased expression of CXCR4 protein plerixafor results in decreased activity of CXCR4 protein plerixafor decreases phosphorylation of CXCR4 protein in lymph node and prostate epithelium plerixafor decreases expression of CXCR4 mRNA and protein in lymph node and prostate epithelium
CTD RGD
PMID:12220670 PMID:17121897 PMID:28844962 PMID:24912495 PMID:30537000 PMID:30537000 More...
RGD:151893463 , RGD:152025215 , RGD:152025215
NCBI chr13:42,630,383...42,634,288
Ensembl chr13:40,077,976...40,081,883
G
Nos3
nitric oxide synthase 3
multiple interactions
ISO
plerixafor inhibits the reaction [CXCL12 protein results in increased phosphorylation of NOS3 protein]
CTD
PMID:18660423
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
G
Snai2
snail family transcriptional repressor 2
multiple interactions
ISO
plerixafor inhibits the reaction [bisphenol A results in increased expression of SNAI2 protein]; plerixafor inhibits the reaction [Estradiol results in increased expression of SNAI2 protein]; plerixafor inhibits the reaction [Triclosan results in increased expression of SNAI2 protein]
CTD
PMID:28844962
NCBI chr11:99,686,934...99,690,349
Ensembl chr11:86,181,909...86,186,200
G
Vegfa
vascular endothelial growth factor A
multiple interactions
ISO
Particulate Matter results in decreased susceptibility to [VEGFA protein modified form co-treated with plerixafor] plerixafor inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]
CTD
PMID:22418586 PMID:25815440
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
G
Vim
vimentin
decreases expression
ISO
plerixafor decreases expression on VIM protein in lymph node and prostate epithelium
RGD
PMID:30537000
RGD:152025215
NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
G
Akr1c3
aldo-keto reductase family 1, member C3
increases metabolic processing increases reduction decreases response to substance decreases metabolic processing multiple interactions
ISO
AKR1C3 protein results in increased metabolism of Prostaglandin D2 AKR1C3 protein results in increased reduction of Prostaglandin D2 AKR1C3 protein results in decreased susceptibility to Prostaglandin D2 AKR1C3 protein results in decreased metabolism of Prostaglandin D2 [AKR1C3 protein results in decreased metabolism of Prostaglandin D2] which results in decreased chemical synthesis of 9-deoxy-delta-9-prostaglandin D2; [AKR1C3 protein results in increased reduction of Prostaglandin D2] which results in increased chemical synthesis of Dinoprost; [Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]] which results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2; Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]
CTD
PMID:19010312 PMID:19997560 PMID:20036328
NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873
G
App
amyloid beta precursor protein
increases secretion multiple interactions
ISO
APP protein modified form results in increased secretion of Prostaglandin D2 CNB 001 inhibits the reaction [APP protein modified form results in increased secretion of Prostaglandin D2]; Dronabinol inhibits the reaction [APP protein modified form results in increased secretion of Prostaglandin D2]; L 685458 inhibits the reaction [APP protein modified form results in increased secretion of Prostaglandin D2]
CTD
PMID:28721267
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
G
Arhgdib
Rho GDP dissociation inhibitor beta
increases cleavage
ISO
Prostaglandin D2 results in increased cleavage of ARHGDIB protein
CTD
PMID:15843042
NCBI chr 4:171,554,139...171,573,057
Ensembl chr 4:169,822,952...169,841,658
G
Casp3
caspase 3
increases activity increases cleavage
ISO EXP
Prostaglandin D2 results in increased activity of CASP3 protein Prostaglandin D2 results in increased cleavage of CASP3 protein
CTD
PMID:15843042 PMID:23973622
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
G
Cryab
crystallin, alpha B
multiple interactions
EXP
Prostaglandin D2 promotes the reaction [arsenite results in increased expression of CRYAB protein]
CTD
PMID:9066782
NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:51,093,441...51,099,157
G
Cxcl2
C-X-C motif chemokine ligand 2
increases expression multiple interactions
ISO
Prostaglandin D2 results in increased expression of CXCL2 protein [Lipopolysaccharides results in increased abundance of Prostaglandin D2] which results in increased expression of CXCL2 protein; PTGDR protein promotes the reaction [[Lipopolysaccharides results in increased abundance of Prostaglandin D2] which results in increased expression of CXCL2 protein]
CTD
PMID:21166666
NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075
G
Egf
epidermal growth factor
multiple interactions
EXP
[EGF protein co-treated with Prostaglandin D2] results in increased expression of MYC mRNA
CTD
PMID:12632255
NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064
G
Ephx2
epoxide hydrolase 2
multiple interactions
ISO
EPHX2 gene mutant form promotes the reaction [Aspirin inhibits the reaction [Lipopolysaccharides results in increased abundance of Prostaglandin D2]]
CTD
PMID:19896470
NCBI chr15:44,465,447...44,503,157
Ensembl chr15:40,289,902...40,327,615
G
Fabp4
fatty acid binding protein 4
increases expression
ISO
Prostaglandin D2 results in increased expression of FABP4 mRNA
CTD
PMID:9543393
NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578
G
Hpgds
hematopoietic prostaglandin D synthase
multiple interactions
ISO
[4-benzhydryloxy-1-(3-(1H-tetrazol-5-yl-)-propyl)piperidine results in increased expression of HPGDS mRNA] which results in decreased abundance of Prostaglandin D2
CTD
PMID:21352547
NCBI chr 4:95,698,265...95,727,733
Ensembl chr 4:94,373,342...94,397,883
G
Il1b
interleukin 1 beta
multiple interactions increases abundance increases expression increases secretion
ISO EXP
[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Prostaglandin D2; Indomethacin inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Prostaglandin D2]; resveratrol inhibits the reaction [IL1B protein results in increased abundance of Prostaglandin D2] Prostaglandin D2 results in increased expression of IL1B protein [Lipopolysaccharides results in increased abundance of Prostaglandin D2] which results in increased expression of IL1B protein; PTGDR protein promotes the reaction [[Lipopolysaccharides results in increased abundance of Prostaglandin D2] which results in increased expression of IL1B protein] IL1B protein results in increased secretion of Prostaglandin D2 IL1B protein promotes the reaction [rosiglitazone results in increased secretion of Prostaglandin D2]
CTD
PMID:12743569 PMID:12897060 PMID:19751497 PMID:21166666
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
G
Il4
interleukin 4
multiple interactions
ISO
4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]]; [Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of Prostaglandin D2]
CTD
PMID:23688403
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
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Il6
interleukin 6
multiple interactions
ISO
[Lipopolysaccharides results in increased abundance of Prostaglandin D2] which results in increased expression of IL6 protein; PTGDR protein promotes the reaction [[Lipopolysaccharides results in increased abundance of Prostaglandin D2] which results in increased expression of IL6 protein]
CTD
PMID:21166666
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
G
Lypla2
lysophospholipase 2
increases hydrolysis
ISO
LYPLA2 protein results in increased hydrolysis of Prostaglandin D2 analog
CTD
PMID:25301951
NCBI chr 5:153,481,973...153,486,692
Ensembl chr 5:148,198,439...148,203,092
G
Mapk1
mitogen activated protein kinase 1
increases phosphorylation
ISO
Prostaglandin D2 results in increased phosphorylation of MAPK1 protein
CTD
PMID:24813642
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
G
Mapk3
mitogen activated protein kinase 3
increases phosphorylation
ISO
Prostaglandin D2 results in increased phosphorylation of MAPK3 protein
CTD
PMID:24813642
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
G
Myc
MYC proto-oncogene, bHLH transcription factor
multiple interactions
EXP
[EGF protein co-treated with Prostaglandin D2] results in increased expression of MYC mRNA
CTD
PMID:12632255
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage
ISO EXP
Prostaglandin D2 results in increased cleavage of PARP1 protein
CTD
PMID:15843042 PMID:23973622
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions affects localization
ISO
Prostaglandin D2 affects the localization of and results in increased expression of PPARG protein Prostaglandin D2 affects the localization of PPARG protein
CTD
PMID:23220503 PMID:23943857
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
G
Ppargc1a
PPARG coactivator 1 alpha
increases expression
ISO
Prostaglandin D2 results in increased expression of PPARGC1A mRNA
CTD
PMID:23056435
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
G
Ppp1r12a
protein phosphatase 1, regulatory subunit 12A
increases phosphorylation
ISO
Prostaglandin D2 results in increased phosphorylation of PPP1R12A protein
CTD
PMID:24813642
NCBI chr 7:45,368,922...45,480,158
Ensembl chr 7:43,482,803...43,593,425
G
Ptgdr
prostaglandin D2 receptor
multiple interactions
ISO
13,14-dihydro-15-ketoprostaglandin D2 inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]; 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]; adenosine 5'-O-(3-thiotriphosphate) inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]; Adenylyl Imidodiphosphate inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]; Alprostadil inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]; BW 245C inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]; BW A868C inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]; delta(12)-prostaglandin J(2) inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]; Dinoprost inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]; Dinoprostone inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]; Guanosine 5'-O-(3-Thiotriphosphate) inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]; Guanylyl Imidodiphosphate inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]; Iloprost inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]; L 644698 inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]; Prostaglandin D2 binds to and results in increased activity of PTGDR protein; ZK 110841 inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] [Prostaglandin D2 results in increased activity of PTGDR protein] which results in increased metabolism of Adenosine; [Prostaglandin D2 results in increased activity of PTGDR protein] which results in increased secretion of Adenosine; PTGDR protein promotes the reaction [[Lipopolysaccharides results in increased abundance of Prostaglandin D2] which results in increased expression of CXCL2 protein]; PTGDR protein promotes the reaction [[Lipopolysaccharides results in increased abundance of Prostaglandin D2] which results in increased expression of IL1B protein]; PTGDR protein promotes the reaction [[Lipopolysaccharides results in increased abundance of Prostaglandin D2] which results in increased expression of IL6 protein]
CTD
PMID:9579725 PMID:11562489 PMID:21166666 PMID:27636113
NCBI chr15:19,790,499...19,797,873
Ensembl chr15:17,360,304...17,367,679
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Ptgdr2
prostaglandin D2 receptor 2
multiple interactions increases activity affects binding
ISO
Endocannabinoids inhibits the reaction [Prostaglandin D2 binds to and results in increased activity of PTGDR2 protein]; Prostaglandin D2 binds to and results in increased activity of PTGDR2 protein; ramatroban inhibits the reaction [Prostaglandin D2 binds to and results in increased activity of PTGDR2 protein] Prostaglandin D2 results in increased activity of PTGDR2 protein 13,14-dihydro-15-ketoprostaglandin D2 inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]; 5-hydroxyindomethacin inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]; Indomethacin inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]; ramatroban inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]; sulindac sulfide inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]; zomepirac inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]
CTD
PMID:11801628 PMID:12721327 PMID:15563582 PMID:16256979 PMID:21916510 PMID:30102254 More...
NCBI chr 1:217,010,183...217,015,044
Ensembl chr 1:207,587,917...207,589,213
G
Ptger2
prostaglandin E receptor 2
multiple interactions
ISO
Prostaglandin D2 binds to and results in increased activity of PTGER2 protein
CTD
PMID:27636113
NCBI chr15:20,694,765...20,708,475
Ensembl chr15:18,217,285...18,228,714
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
[2-chloro-N-(4-chlorobiphenyl-2-yl)nicotinamide binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2; [2-phenylphenol binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2; [Acetaminophen results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Prostaglandin D2; [Chlorpropham binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2; [cypermethrin binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2; [cyprodinil binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2; [enilconazole binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2; [fludioxonil binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2; [Ibuprofen binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2; [Linuron binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2; [Methiocarb binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2; [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2; [Nanotubes, Carbon co-treated with PTGS2 gene mutant form] results in increased abundance of Prostaglandin D2; [pirimiphos methyl binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Prostaglandin D2; [PTGS2 gene mutant form results in increased susceptibility to Nanotubes, Carbon] which results in increased abundance of Prostaglandin D2; [pyrimethanil binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2; [tebuconazole binds to and results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of and results in decreased secretion of Prostaglandin D2
CTD
PMID:11743745 PMID:18834901 PMID:23642096 PMID:26359731
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
G
Rorc
RAR-related orphan receptor C
increases expression
ISO
Prostaglandin D2 results in increased expression of RORC mRNA
CTD
PMID:9543393
NCBI chr 2:184,698,779...184,723,942
Ensembl chr 2:182,009,286...182,034,907
G
Slc22a22
solute carrier family 22 member 22
affects binding
ISO
Prostaglandin D2 binds to SLC22A22 protein
CTD
PMID:20448048
NCBI chr 7:90,610,007...90,639,718
Ensembl chr 7:88,720,427...88,750,111
G
Tac1
tachykinin, precursor 1
multiple interactions
EXP
Prostaglandin D2 promotes the reaction [Kallidin results in increased secretion of TAC1 protein]
CTD
PMID:16039053
NCBI chr 4:36,645,344...36,653,548
Ensembl chr 4:35,679,704...35,687,178
G
Tg
thyroglobulin
multiple interactions increases expression
ISO
Prostaglandin D2 promotes the reaction [TSHB protein results in increased expression of TG protein] Prostaglandin D2 results in increased expression of TG protein
CTD
PMID:11078701
NCBI chr 7:100,307,349...100,492,246
Ensembl chr 7:98,418,293...98,603,210
G
Tgfb1
transforming growth factor, beta 1
decreases response to substance
ISO
Prostaglandin D2 results in decreased susceptibility to TGFB1 protein
CTD
PMID:20719937
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
G
Tnf
tumor necrosis factor
multiple interactions increases abundance
ISO
[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Prostaglandin D2; Indomethacin inhibits the reaction [[Lipopolysaccharides co-treated with IL1B protein co-treated with TNF protein] results in increased abundance of Prostaglandin D2] TNF protein results in increased abundance of Prostaglandin D2
CTD
PMID:1993070 PMID:12743569
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Tnfrsf11b
TNF receptor superfamily member 11B
increases secretion increases expression multiple interactions
ISO
Prostaglandin D2 results in increased secretion of TNFRSF11B protein Prostaglandin D2 results in increased expression of TNFRSF11B mRNA 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Prostaglandin D2 results in increased secretion of TNFRSF11B protein]; pyrazolanthrone inhibits the reaction [Prostaglandin D2 results in increased secretion of TNFRSF11B protein]; resveratrol inhibits the reaction [Prostaglandin D2 results in increased expression of TNFRSF11B mRNA]; resveratrol inhibits the reaction [Prostaglandin D2 results in increased secretion of TNFRSF11B protein]; SB 203580 inhibits the reaction [Prostaglandin D2 results in increased secretion of TNFRSF11B protein]; SRT1720 inhibits the reaction [Prostaglandin D2 results in increased expression of TNFRSF11B mRNA]; SRT1720 inhibits the reaction [Prostaglandin D2 results in increased secretion of TNFRSF11B protein]
CTD
PMID:24813642
NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:85,566,520...85,594,538
G
Tshb
thyroid stimulating hormone subunit beta
multiple interactions
ISO
Prostaglandin D2 promotes the reaction [TSHB protein results in increased expression of TG protein]
CTD
PMID:11078701
NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:190,224,676...190,229,559
G
Ucp2
uncoupling protein 2
affects chemical synthesis
ISO
UCP2 protein affects the chemical synthesis of Prostaglandin D2
CTD
PMID:19846869
NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611
G
Il1b
interleukin 1 beta
multiple interactions
ISO
prostaglandin D3 promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]
CTD
PMID:12573452
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
G
Ptgs2
prostaglandin-endoperoxide synthase 2
multiple interactions
ISO
prostaglandin D3 promotes the reaction [IL1B protein results in increased expression of PTGS2 protein]
CTD
PMID:12573452
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
G
Abca1
ATP binding cassette subfamily A member 1
multiple interactions
ISO
[9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] which results in increased expression of ABCA1 mRNA
CTD
PMID:12595494
NCBI chr 5:72,473,676...72,596,563
Ensembl chr 5:67,681,297...67,801,170
G
Akr1c3
aldo-keto reductase family 1, member C3
multiple interactions
ISO
[AKR1C3 protein results in decreased metabolism of Prostaglandin D2] which results in decreased chemical synthesis of 9-deoxy-delta-9-prostaglandin D2
CTD
PMID:20036328
NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873
G
Apoa1
apolipoprotein A1
multiple interactions
ISO
[9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol]
CTD
PMID:12595494
NCBI chr 8:55,423,945...55,425,729
Ensembl chr 8:46,527,144...46,529,035
G
Arhgdib
Rho GDP dissociation inhibitor beta
increases cleavage
ISO
9-deoxy-delta-9-prostaglandin D2 results in increased cleavage of ARHGDIB protein
CTD
PMID:15843042
NCBI chr 4:171,554,139...171,573,057
Ensembl chr 4:169,822,952...169,841,658
G
Casp3
caspase 3
increases activity multiple interactions
ISO EXP
9-deoxy-delta-9-prostaglandin D2 results in increased activity of CASP3 protein [delta(12)-prostaglandin J(2) co-treated with 9-deoxy-delta-9-prostaglandin D2 co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in increased cleavage of CASP3 protein
CTD
PMID:15843042 PMID:23973622
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
G
Cebpb
CCAAT/enhancer binding protein beta
multiple interactions
EXP
[9-deoxy-delta-9-prostaglandin D2 co-treated with alitretinoin] results in increased activity of CEBPB protein
CTD
PMID:15150131
NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473
G
Ces1d
carboxylesterase 1D
decreases expression
ISO
9-deoxy-delta-9-prostaglandin D2 results in decreased expression of CES1 mRNA
CTD
PMID:11409902
NCBI chr19:30,046,494...30,085,039
Ensembl chr19:13,796,623...13,912,035
G
Cryab
crystallin, alpha B
multiple interactions
EXP
9-deoxy-delta-9-prostaglandin D2 promotes the reaction [arsenite results in increased expression of CRYAB mRNA]; 9-deoxy-delta-9-prostaglandin D2 promotes the reaction [arsenite results in increased expression of CRYAB protein]
CTD
PMID:9066782
NCBI chr 8:59,989,885...59,995,532
Ensembl chr 8:51,093,441...51,099,157
G
Ep300
E1A binding protein p300
decreases activity
ISO
9-deoxy-delta-9-prostaglandin D2 results in decreased activity of EP300 protein
CTD
PMID:22141352
NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
G
Gclc
glutamate-cysteine ligase, catalytic subunit
increases expression
EXP
9-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLC mRNA; 9-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLC protein
CTD
PMID:18332871
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
G
Gclm
glutamate cysteine ligase, modifier subunit
increases expression
EXP
9-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLM mRNA; 9-deoxy-delta-9-prostaglandin D2 results in increased expression of GCLM protein
CTD
PMID:18332871
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535
G
Gdf15
growth differentiation factor 15
increases expression multiple interactions
ISO
9-deoxy-delta-9-prostaglandin D2 results in increased expression of GDF15 mRNA; 9-deoxy-delta-9-prostaglandin D2 results in increased expression of GDF15 protein [2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [9-deoxy-delta-9-prostaglandin D2 results in increased expression of GDF15 protein]
CTD
PMID:14662774
NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055
G
Gsta1
glutathione S-transferase alpha 1
affects metabolic processing
ISO
GSTA1 protein affects the metabolism of 9-deoxy-delta-9-prostaglandin D2
CTD
PMID:9084911
NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:23,703,477...23,720,121
G
Gsta2
glutathione S-transferase alpha 2
increases expression affects metabolic processing multiple interactions
EXP ISO
9-deoxy-delta-9-prostaglandin D2 results in increased expression of GSTA2 protein GSTA2 protein affects the metabolism of 9-deoxy-delta-9-prostaglandin D2 [9-deoxy-delta-9-prostaglandin D2 co-treated with alitretinoin] promotes the reaction [[PPARG protein binds to RXRA protein] which binds to GSTA2 promoter]; [9-deoxy-delta-9-prostaglandin D2 co-treated with alitretinoin] results in increased expression of GSTA2 mRNA; [9-deoxy-delta-9-prostaglandin D2 co-treated with alitretinoin] results in increased expression of GSTA2 protein
CTD
PMID:9084911 PMID:15150131
NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:79,184,322...79,196,798
G
Gstm1
glutathione S-transferase mu 1
affects metabolic processing
ISO
GSTM1 protein affects the metabolism of 9-deoxy-delta-9-prostaglandin D2
CTD
PMID:9084911
NCBI chr 2:198,338,005...198,346,007
Ensembl chr 2:195,649,845...195,655,411
G
Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases expression
ISO
9-deoxy-delta-9-prostaglandin D2 results in increased expression of JUN protein modified form
CTD
PMID:11401521
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
G
Nfe2l2
NFE2 like bZIP transcription factor 2
multiple interactions
EXP
[9-deoxy-delta-9-prostaglandin D2 co-treated with alitretinoin] results in increased activity of NFE2L2 protein
CTD
PMID:15150131
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
G
Nr1h3
nuclear receptor subfamily 1, group H, member 3
multiple interactions
ISO
[9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] which results in increased expression of NR1H3 mRNA
CTD
PMID:12595494
NCBI chr 3:97,614,616...97,632,053
Ensembl chr 3:77,158,808...77,168,722
G
Parp1
poly (ADP-ribose) polymerase 1
increases cleavage multiple interactions
ISO EXP
9-deoxy-delta-9-prostaglandin D2 results in increased cleavage of PARP1 protein [delta(12)-prostaglandin J(2) co-treated with 9-deoxy-delta-9-prostaglandin D2 co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in increased cleavage of PARP1 protein
CTD
PMID:15843042 PMID:23973622
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
G
Pparg
peroxisome proliferator-activated receptor gamma
multiple interactions increases expression increases activity
ISO EXP
9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein; [2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [9-deoxy-delta-9-prostaglandin D2 results in increased expression of GDF15 protein]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased expression of ABCA1 mRNA]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [[25-hydroxycholesterol binds to and results in increased activity of NR1H3 protein] which results in increased transport of Cholesterol]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] promotes the reaction [APOA1 protein results in increased transport of Cholesterol]; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] which results in increased expression of ABCA1 mRNA; [9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PPARG protein] which results in increased expression of NR1H3 mRNA; Ethanol inhibits the reaction [9-deoxy-delta-9-prostaglandin D2 results in increased activity of PPARG protein] 9-deoxy-delta-9-prostaglandin D2 results in increased expression of PPARG mRNA 9-deoxy-delta-9-prostaglandin D2 promotes the reaction [PPARG protein alternative form results in decreased activity of SLC2A4 promoter]; [9-deoxy-delta-9-prostaglandin D2 co-treated with Alitretinoin] promotes the reaction [[PPARG protein binds to RXRA protein] which binds to GSTA2 promoter]
CTD
PMID:11343236 PMID:12595494 PMID:12777391 PMID:14512786 PMID:14662774 PMID:15150131 PMID:15491415 PMID:17030193 More...
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
G
Ptgdr
prostaglandin D2 receptor
multiple interactions
ISO
9-deoxy-delta-9-prostaglandin D2 binds to and results in increased activity of PTGDR protein; 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [Prostaglandin D2 binds to PTGDR protein]
CTD
PMID:9579725
NCBI chr15:19,790,499...19,797,873
Ensembl chr15:17,360,304...17,367,679
G
Rxra
retinoid X receptor alpha
multiple interactions
EXP
[9-deoxy-delta-9-prostaglandin D2 co-treated with alitretinoin] promotes the reaction [[PPARG protein binds to RXRA protein] which binds to GSTA2 promoter]
CTD
PMID:15150131
NCBI chr 3:31,387,892...31,474,415
Ensembl chr 3:10,989,832...11,073,712
G
Slc2a4
solute carrier family 2 member 4
multiple interactions
EXP
9-deoxy-delta-9-prostaglandin D2 promotes the reaction [PPARG protein alternative form results in decreased activity of SLC2A4 promoter]
CTD
PMID:12777391
NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565
G
Tg
thyroglobulin
multiple interactions increases expression
ISO
9-deoxy-delta-9-prostaglandin D2 promotes the reaction [TSHB protein results in increased expression of TG protein] 9-deoxy-delta-9-prostaglandin D2 results in increased expression of TG protein
CTD
PMID:11078701
NCBI chr 7:100,307,349...100,492,246
Ensembl chr 7:98,418,293...98,603,210
G
Tshb
thyroid stimulating hormone subunit beta
multiple interactions
ISO
9-deoxy-delta-9-prostaglandin D2 promotes the reaction [TSHB protein results in increased expression of TG protein]
CTD
PMID:11078701
NCBI chr 2:192,913,171...192,918,054
Ensembl chr 2:190,224,676...190,229,559
G
Cyp3a2
cytochrome P450, family 3, subfamily a, polypeptide 2
affects activity
ISO
rubiarbonone C affects the activity of CYP3A4 protein
CTD
PMID:30259074
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
G
Cyp4f18
cytochrome P450, family 4, subfamily f, polypeptide 18
multiple interactions decreases activity
ISO
rubiarbonone C inhibits the reaction [CYP4F3 protein alternative form results in increased hydroxylation of Arachidonic Acid] rubiarbonone C results in decreased activity of CYP4F3 protein alternative form
CTD
PMID:30259074
NCBI chr16:17,797,558...17,838,958
Ensembl chr16:17,707,317...17,804,940
G
Ar
androgen receptor
multiple interactions
ISO
Tea Tree Oil inhibits the reaction [Testosterone results in increased activity of AR protein]
CTD
PMID:31393563
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925
G
Ctsd
cathepsin D
increases expression multiple interactions
ISO
Tea Tree Oil results in increased expression of CTSD mRNA Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of CTSD mRNA]
CTD
PMID:31393563
NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488
G
Cyp4f6
cytochrome P450, family 4, subfamily f, polypeptide 6
multiple interactions
ISO
Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of CYP4F8 mRNA]
CTD
PMID:31393563
NCBI chr 7:12,680,799...12,708,378
Ensembl chr 7:12,030,301...12,057,782
G
Esr1
estrogen receptor 1
increases activity
ISO
Tea Tree Oil results in increased activity of ESR1 protein
CTD
PMID:31393563
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
G
Greb1
growth regulating estrogen receptor binding 1
increases expression multiple interactions
ISO
Tea Tree Oil results in increased expression of GREB1 mRNA Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of GREB1 mRNA]
CTD
PMID:31393563
NCBI chr 6:45,169,289...45,321,973
Ensembl chr 6:39,440,504...39,581,633
G
Pgr
progesterone receptor
increases expression multiple interactions
ISO
Tea Tree Oil results in increased expression of PGR mRNA Fulvestrant inhibits the reaction [Tea Tree Oil results in increased expression of PGR mRNA]
CTD
PMID:31393563
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
G
Sec14l2
SEC14-like lipid binding 2
multiple interactions
ISO
Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of SEC14L2 mRNA]
CTD
PMID:31393563
NCBI chr14:78,973,805...78,998,480
Ensembl chr14:78,973,808...78,993,788
G
Ugt2b34l1
UDP glucuronosyltransferase 2 family, polypeptide B34 like 1
multiple interactions
ISO
Tea Tree Oil inhibits the reaction [Testosterone results in increased expression of UGT2B28 mRNA]
CTD
PMID:31393563
NCBI chr14:21,146,140...21,167,706
Ensembl chr14:21,145,827...21,167,704
G
Comt
catechol-O-methyltransferase
decreases activity
EXP
Tropolone results in decreased activity of COMT protein
CTD
PMID:10064789
NCBI chr11:96,072,371...96,091,956
Ensembl chr11:82,568,025...82,587,642
G
Akt1
AKT serine/threonine kinase 1
multiple interactions
EXP
zingiberene inhibits the reaction [Isoproterenol results in increased expression of AKT1 mRNA]
CTD
PMID:33242989
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
G
Bax
BCL2 associated X, apoptosis regulator
multiple interactions
EXP
zingiberene inhibits the reaction [Isoproterenol results in increased expression of BAX protein]
CTD
PMID:33242989
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
G
Bcl2
BCL2, apoptosis regulator
multiple interactions
EXP
zingiberene inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]
CTD
PMID:33242989
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
G
Casp3
caspase 3
multiple interactions
EXP
zingiberene inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]
CTD
PMID:33242989
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
G
Cat
catalase
multiple interactions
EXP
zingiberene inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]
CTD
PMID:33242989
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
G
Cycs
cytochrome c, somatic
multiple interactions
EXP
zingiberene inhibits the reaction [Isoproterenol results in increased expression of CYCS protein]
CTD
PMID:33242989
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
G
Il1b
interleukin 1 beta
multiple interactions
EXP
zingiberene inhibits the reaction [Isoproterenol results in increased expression of IL1B mRNA]; zingiberene inhibits the reaction [Isoproterenol results in increased expression of IL1B protein]
CTD
PMID:33242989
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
G
Il6
interleukin 6
multiple interactions
EXP
zingiberene inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA]; zingiberene inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]
CTD
PMID:33242989
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
G
Mmp2
matrix metallopeptidase 2
multiple interactions
EXP
zingiberene inhibits the reaction [Isoproterenol results in increased expression of MMP2 mRNA]
CTD
PMID:33242989
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
G
Mmp9
matrix metallopeptidase 9
multiple interactions
EXP
zingiberene inhibits the reaction [Isoproterenol results in increased expression of MMP9 mRNA]
CTD
PMID:33242989
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
G
Nos2
nitric oxide synthase 2
multiple interactions
EXP
zingiberene inhibits the reaction [Isoproterenol results in increased expression of NOS2 mRNA]
CTD
PMID:33242989
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
G
Nos3
nitric oxide synthase 3
multiple interactions
EXP
zingiberene inhibits the reaction [Isoproterenol results in increased expression of NOS3 mRNA]
CTD
PMID:33242989
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
G
Rela
RELA proto-oncogene, NF-kB subunit
multiple interactions
EXP
zingiberene inhibits the reaction [Isoproterenol results in increased expression of RELA protein]
CTD
PMID:33242989
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
G
Tnf
tumor necrosis factor
multiple interactions
EXP
zingiberene inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA]; zingiberene inhibits the reaction [Isoproterenol results in increased expression of TNF protein]
CTD
PMID:33242989
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
G
Tnni3
troponin I3, cardiac type
multiple interactions
EXP
zingiberene inhibits the reaction [Isoproterenol results in increased expression of TNNI3 mRNA]; zingiberene inhibits the reaction [Isoproterenol results in increased expression of TNNI3 protein]
CTD
PMID:33242989
NCBI chr 1:78,342,571...78,346,255
Ensembl chr 1:69,299,900...69,303,580
G
Vegfa
vascular endothelial growth factor A
multiple interactions
EXP
zingiberene inhibits the reaction [Isoproterenol results in increased expression of VEGFA mRNA]
CTD
PMID:33242989
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
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