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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alicyclic compound
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Accession:CHEBI:33654 term browser browse the term
Definition:An aliphatic compound having a carbocyclic ring structure which may be saturated or unsaturated, but may not be a benzenoid or other aromatic system.
Synonyms:exact_synonym: alicyclic compounds


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(+)-beta-thujone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Chrna7 cholinergic receptor nicotinic alpha 7 subunit multiple interactions ISO beta-thujone inhibits the reaction [Acetylcholine results in increased activity of CHRNA7 protein]; beta-thujone inhibits the reaction [Choline results in increased activity of CHRNA7 protein] CTD PMID:28395994 NCBI chr 1:116,715,286...116,837,223
Ensembl chr 1:116,714,711...116,837,240
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO beta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO beta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO beta-thujone inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
(R)-camphor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a2 collagen type I alpha 2 chain affects expression ISO Camphor analog affects the expression of COL1A2 mRNA CTD PMID:24704097 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP Camphor results in decreased activity of CYP2B1 protein CTD PMID:9242356 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO Camphor inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion] CTD PMID:18611395 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Camphor binds to and results in increased activity of ESR1 protein CTD PMID:27633901 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Camphor inhibits the reaction [cinnamaldehyde results in increased activity of MPO protein] CTD PMID:21466812 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Camphor binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Runx2 RUNX family transcription factor 2 affects expression ISO Camphor analog affects the expression of RUNX2 mRNA CTD PMID:24704097 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Sparc secreted protein acidic and cysteine rich affects expression ISO Camphor analog affects the expression of SPARC mRNA CTD PMID:24704097 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP Lidocaine promotes the reaction [Camphor results in increased activity of TRPV1 protein] CTD PMID:18172555 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity
multiple interactions
ISO Camphor results in increased activity of TRPV3 protein
isopentenyl pyrophosphate inhibits the reaction [Camphor results in increased activity of TRPV3 protein]
CTD PMID:21353389 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296
JBrowse link
(S)-(-)-perillyl alcohol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bak1 BCL2-antagonist/killer 1 increases expression ISO perillyl alcohol results in increased expression of BAK1 protein CTD PMID:12530055 NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of BAX protein] CTD PMID:19161993 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of BCL2 protein] CTD PMID:19161993 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Cat catalase multiple interactions ISO
EXP
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased activity of CAT protein]
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of CAT protein]
CTD PMID:19161993 PMID:20923693 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO perillyl alcohol results in decreased expression of CCNA2 protein CTD PMID:17138864 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO perillyl alcohol results in decreased expression of CCNB1 protein CTD PMID:17138864 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression
multiple interactions
ISO perillyl alcohol results in decreased expression of CDK2 protein
perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]; perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
CTD PMID:17138864 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases response to substance
multiple interactions
increases expression
ISO CDKN1A protein results in increased susceptibility to perillyl alcohol
perillyl alcohol promotes the reaction [CDKN1A protein binds to and results in decreased activity of CDK2 protein]
perillyl alcohol results in increased expression of CDKN1A protein
CTD PMID:17138864 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
increases response to substance
multiple interactions
ISO perillyl alcohol results in increased expression of CDKN1B protein
CDKN1B protein results in increased susceptibility to perillyl alcohol
perillyl alcohol promotes the reaction [CDKN1B protein binds to and results in decreased activity of CDK2 protein]
CTD PMID:17138864 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Fbxo32 F-box protein 32 increases expression ISO perillyl alcohol results in increased expression of FBXO32 mRNA; perillyl alcohol results in increased expression of FBXO32 protein CTD PMID:19406843 NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436
JBrowse link
G Fnta farnesyltransferase, CAAX box, alpha multiple interactions EXP [Vitamin A co-treated with perillyl alcohol] results in decreased expression of FNTA protein CTD PMID:15959631 NCBI chr16:66,065,131...66,083,460
Ensembl chr16:66,065,132...66,083,460
JBrowse link
G Fntb farnesyltransferase, CAAX box, beta multiple interactions
increases expression
decreases expression
EXP [perillyl alcohol co-treated with Vitamin A] results in decreased expression of FNTB mRNA
perillyl alcohol results in increased expression of FNTB protein
perillyl alcohol results in decreased expression of FNTB mRNA
CTD PMID:15959631 NCBI chr 6:95,536,540...95,619,587
Ensembl chr 6:95,470,683...95,619,586
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions ISO
EXP
perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GSR protein]
perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of GSR protein]
CTD PMID:19161993 PMID:20923693 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) multiple interactions EXP perillyl alcohol inhibits the reaction [Ethanol results in decreased activity of H6PD protein] CTD PMID:20923693 NCBI chr 5:160,434,499...160,470,203
Ensembl chr 5:160,438,697...160,470,171
JBrowse link
G Ivl involucrin decreases expression ISO perillyl alcohol results in decreased expression of IVL protein CTD PMID:10769631 NCBI chr 2:178,146,694...178,160,807
Ensembl chr 2:178,147,061...178,149,100
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] CTD PMID:19161993 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] CTD PMID:19161993 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of ODC1 protein] CTD PMID:19161993 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO perillyl alcohol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RAF1 protein] CTD PMID:19161993 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rap1a RAP1A, member of RAS oncogene family multiple interactions
increases expression
ISO Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RAP1A protein] CTD PMID:12671036 NCBI chr 2:193,208,631...193,286,513
Ensembl chr 2:193,208,635...193,286,501
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP perillyl alcohol inhibits the reaction [Ethanol results in increased activity of RELA protein] CTD PMID:20923693 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rhoa ras homolog family member A multiple interactions
increases expression
ISO
EXP
Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOA protein]
[perillyl alcohol co-treated with Vitamin A] results in increased expression of RHOA mRNA
CTD PMID:12671036 PMID:15959631 NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
JBrowse link
G Rhob ras homolog family member B multiple interactions
increases expression
ISO
EXP
Mevalonic Acid affects the reaction [perillyl alcohol results in increased expression of RHOB protein]
perillyl alcohol results in increased expression of RHOB mRNA; perillyl alcohol results in increased expression of RHOB protein
[perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB mRNA; [perillyl alcohol co-treated with Vitamin A] affects the expression of RHOB protein
CTD PMID:12671036 PMID:15959631 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP perillyl alcohol inhibits the reaction [Ethanol results in increased expression of TNF protein] CTD PMID:20923693 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
13,14-dihydro-15-ketoprostaglandin D2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cxcl2 C-X-C motif chemokine ligand 2 increases expression
multiple interactions
ISO 13,14-dihydro-15-ketoprostaglandin D2 results in increased expression of CXCL2 protein
13,14-dihydro-15-ketoprostaglandin D2 promotes the reaction [Flutamide results in increased expression of CXCL2 mRNA]
CTD PMID:21094227 PMID:21735453 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Gata3 GATA binding protein 3 multiple interactions ISO 13,14-dihydro-15-ketoprostaglandin D2 promotes the reaction [Flutamide results in increased expression of GATA3 mRNA] CTD PMID:21735453 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391
JBrowse link
G Il4 interleukin 4 multiple interactions ISO 13,14-dihydro-15-ketoprostaglandin D2 promotes the reaction [Flutamide results in increased expression of IL4 protein] CTD PMID:21735453 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Ptgdr prostaglandin D2 receptor multiple interactions ISO 13,14-dihydro-15-ketoprostaglandin D2 binds to and results in increased activity of PTGDR protein; 13,14-dihydro-15-ketoprostaglandin D2 inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 NCBI chr15:17,360,304...17,367,679 JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 multiple interactions ISO
EXP
13,14-dihydro-15-ketoprostaglandin D2 inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]
13,14-dihydro-15-ketoprostaglandin D2 binds to and results in increased activity of PTGDR2 protein
13,14-dihydro-15-ketoprostaglandin D2 binds to and results in increased activity of PTGDR2 protein; ramatroban inhibits the reaction [13,14-dihydro-15-ketoprostaglandin D2 binds to and results in increased activity of PTGDR2 protein]
CTD PMID:12721327 PMID:15528449 PMID:16256979 NCBI chr 1:207,585,088...207,590,275
Ensembl chr 1:207,587,917...207,589,213
JBrowse link
13,14-dihydro-Delta(12)-prostaglandin J2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bdnf brain-derived neurotrophic factor increases expression
multiple interactions
EXP 9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of BDNF mRNA
Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of BDNF mRNA]
CTD PMID:22982731 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions
increases expression
EXP Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA]; NFE2L2 protein affects the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA] CTD PMID:22982731 NCBI chr 2:56,893,992...56,919,935
Ensembl chr 2:56,895,010...56,917,209
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP NFE2L2 protein affects the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of GDNF mRNA] CTD PMID:22982731 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Ngf nerve growth factor multiple interactions
increases expression
EXP Dactinomycin inhibits the reaction [9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydroprostaglandin D2 analog results in increased expression of NGF mRNA] CTD PMID:22982731 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
15-deoxy-Delta(12,14)-prostaglandin J2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
affects export
affects glutathionylation
increases transport
ISO [ABCC1 protein results in increased transport of 15-deoxy-delta(12,14)-prostaglandin J2 metabolite] affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]
ABCC1 protein affects the export of 15-deoxy-delta(12,14)-prostaglandin J2 analog
ABCC1 protein affects the glutathionylation of 15-deoxy-delta(12,14)-prostaglandin J2
CTD PMID:14979731 PMID:21728338 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 affects export ISO ABCC3 protein affects the export of 15-deoxy-delta(12,14)-prostaglandin J2 analog CTD PMID:14979731 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Agt angiotensinogen multiple interactions EXP 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in decreased expression of PPARG protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]] CTD PMID:18278065 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions ISO [Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]] which results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2 CTD PMID:19997560 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of AKT1 protein CTD PMID:16611854 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bglap bone gamma-carboxyglutamate protein decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of BGLAP mRNA CTD PMID:12021203 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of BIRC2 protein CTD PMID:15498850 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of BIRC3 protein CTD PMID:15498850 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions
increases cleavage
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of CASP3 protein
[delta(12)-prostaglandin J(2) co-treated with 9-deoxy-delta-9-prostaglandin D2 co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in increased cleavage of CASP3 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of CASP3 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:11785780 PMID:15498850 PMID:16299251 PMID:23973622 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:15498850 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:15498850 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cat catalase multiple interactions ISO CAT protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]] CTD PMID:12847270 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Dexamethasone binds to NR3C1 protein] which results in decreased expression of CCL2 protein] CTD PMID:15187150 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA] CTD PMID:23688403 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of and results in increased secretion of CCN2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]; SMAD2 protein modified form affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2]] CTD PMID:19429239 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccna2 cyclin A2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCNA2 protein CTD PMID:15729575 NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCNB1 protein CTD PMID:15729575 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnd3 cyclin D3 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCND3 protein CTD PMID:15729575 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CCNE1 protein CTD PMID:15729575 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CDK2 protein CTD PMID:15729575 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
decreases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of CDKN1A
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CDKN1A protein
CTD PMID:15254749 PMID:15729575 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CDKN1B protein CTD PMID:15729575 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of CEBPA mRNA CTD PMID:12021203 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of CFLAR protein CTD PMID:15498850 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of CHUK protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in increased phosphorylation of CHUK protein]
CTD PMID:15498850 PMID:22245093 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of COL1A1 mRNA CTD PMID:12021203 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Csf2 colony stimulating factor 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of CSF2 mRNA]; Dexamethasone promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]] CTD PMID:12604364 PMID:14998300 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Ddx58 DEXD/H-box helicase 58 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of DDX58 mRNA] CTD PMID:16303604 NCBI chr 5:55,321,229...55,369,947
Ensembl chr 5:55,321,235...55,370,819
JBrowse link
G Egr1 early growth response 1 multiple interactions EXP 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of EGR1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Oxygen deficiency results in increased expression of EGR1 mRNA] CTD PMID:12468449 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression
ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Tretinoin] results in increased expression of FABP4 mRNA
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FABP4 mRNA
CTD PMID:9543393 PMID:12021203 PMID:16573735 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Fas Fas cell surface death receptor decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of FAS mRNA CTD PMID:16712844 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [FOS protein binds to JUN protein]]
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]; U 0126 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]; wortmannin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA]
CTD PMID:11457450 PMID:11687581 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]; [ABCC1 protein results in increased transport of 15-deoxy-delta(12,14)-prostaglandin J2 metabolite] affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; [verlukast binds to and results in decreased activity of ABCC1 protein] inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; NFE2L2 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein
CTD PMID:21728338 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gfap glial fibrillary acidic protein increases expression
decreases expression
multiple interactions
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GFAP
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of GFAP mRNA
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ochratoxin A results in decreased expression of GFAP mRNA]
CTD PMID:15254749 PMID:15994020 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Gsta3 glutathione S-transferase alpha 3 increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTA3 mRNA CTD PMID:14652005 NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO GSTM1 protein affects the metabolism of [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with Glutathione] CTD PMID:14979731 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression
multiple interactions
EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 protein
Soybean Oil promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 mRNA]; Soybean Oil promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GSTP1 protein]
CTD PMID:11600134 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hdac1 histone deacetylase 1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HDAC1 mRNA CTD PMID:21957481 NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111
JBrowse link
G Hdac2 histone deacetylase 2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HDAC2 mRNA CTD PMID:21957481 NCBI chr20:40,548,250...40,571,609
Ensembl chr20:40,548,250...40,571,609
JBrowse link
G Hdac3 histone deacetylase 3 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HDAC3 mRNA CTD PMID:21957481 NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects stability
multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 affects the stability of HIF1A protein
Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Buthionine Sulfoximine promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Dithiothreitol inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein]
CTD PMID:17658243 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein; [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased expression of MMP1 mRNA; [[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein; Acetylcysteine inhibits the reaction [[[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein]; HMOX1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of MMP1 protein]; HSF1 protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]; zinc protoporphyrin inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron]
ochratoxin A inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 protein
CTD PMID:11078701 PMID:15618017 PMID:15994020 PMID:19136476 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsf1 heat shock transcription factor 1 multiple interactions ISO HSF1 protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA] CTD PMID:15618017 NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of HSPB1 protein CTD PMID:16299251 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
decreases secretion
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of [STAT1 protein binds to STAT1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased secretion of IFNG protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; CAT protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Hydrogen Peroxide promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased abundance of Nitric Oxide]]; peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased secretion of IFNG protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of IFNG protein
CTD PMID:12847270 PMID:16844232 PMID:19888466 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of IL1A mRNA] CTD PMID:14998300 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
decreases activity
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein affects the localization of RELA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in decreased abundance of Prostaglandins]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased abundance of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [FOS protein binds to JUN protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CXCL8 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of IL1A mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [IL1B protein affects the localization of JUN protein]; Dexamethasone promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of CSF2 mRNA]]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of IL1B protein
[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with IL1B protein] results in decreased secretion of IL1B protein
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of IL1B protein
CTD PMID:11457450 PMID:12604364 PMID:14998300 PMID:15751073 PMID:16461118 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist decreases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of IL1RN mRNA CTD PMID:15751073 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il4 interleukin 4 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CCL5 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of CXCL8 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; 4-(5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-(4-(2H-tetrazol-5-yl)butyl)piperidine inhibits the reaction [Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]]; [Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2; amorolfine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; butenafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Itraconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Ketoconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; luliconazole inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2]; Terbinafine inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in decreased secretion of 15-deoxy-delta(12,14)-prostaglandin J2] CTD PMID:23688403 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:12604364 PMID:12847270 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified inhibits the reaction [INS protein results in increased secretion of Glucose]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of INS mRNA] CTD PMID:14625208 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Irf1 interferon regulatory factor 1 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of IRF1 mRNA] CTD PMID:12847270 NCBI chr10:37,917,155...37,924,166
Ensembl chr10:37,916,670...37,924,166
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of and results in increased activity of JAK2 protein]] CTD PMID:12847270 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [FOS protein binds to JUN protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [IL1B protein affects the localization of JUN protein] CTD PMID:11457450 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Klf6 Kruppel-like factor 6 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein] CTD PMID:16611854 NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
JBrowse link
G Lep leptin multiple interactions
increases secretion
ISO [Dexamethasone co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased secretion of LEP protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased secretion of LEP protein
CTD PMID:11092516 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]] CTD PMID:19922793 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Lpl lipoprotein lipase increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of LPL mRNA CTD PMID:12021203 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
increases phosphorylation
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of MAPK1 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK1 protein; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK1 protein]; U 0126 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK1 protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MAPK1 protein; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK1 protein]
CTD PMID:11687581 PMID:12083801 PMID:16611854 PMID:19888466 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
increases phosphorylation
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of MAPK3 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK3 protein; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK3 protein]; U 0126 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of and results in increased activity of MAPK3 protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]; [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MAPK3 protein; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of MAPK3 protein]
CTD PMID:11687581 PMID:12083801 PMID:16611854 PMID:19888466 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Med1 mediator complex subunit 1 multiple interactions ISO MED1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein] CTD PMID:16324150 NCBI chr10:83,145,538...83,189,260
Ensembl chr10:83,145,568...83,189,299
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of MMP1 protein; [[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased expression of MMP1 mRNA; [[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein; Acetylcysteine inhibits the reaction [[[[15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of HMOX1 protein] which results in increased abundance of Iron] which results in increased abundance of Reactive Oxygen Species] which results in increased expression of MMP1 protein]; Cycloheximide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein]; Dactinomycin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein]; Deferoxamine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 mRNA]; Deferoxamine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 protein]; HMOX1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and results in increased activity of MMP1 protein]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 mRNA] CTD PMID:19136476 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of MMP9 protein; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of MMP9 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of MMP9 mRNA] CTD PMID:19997048 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of MTOR protein CTD PMID:16611854 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Nes nestin increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of NES protein CTD PMID:15212945 NCBI chr 2:173,437,867...173,447,777
Ensembl chr 2:173,438,734...173,447,777
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 affects the localization of and results in increased activity of NFE2L2 protein; 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]; ABCC1 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [NFE2L2 protein results in increased expression of GCLC protein]]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of NFE2L2 protein]; NFE2L2 protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of GCLC protein]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HMOX1 mRNA]; NFE2L2 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of MMP1 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of and affects the localization of NFE2L2 protein; manganese chloride inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of NFE2L2 protein]
CTD PMID:19136476 PMID:21728338 PMID:22245093 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
decreases localization
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased localization of NFKB1 protein
CTD PMID:11457450 PMID:16299251 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases phosphorylation
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased degradation of NFKBIA protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in increased degradation of NFKBIA protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of NFKBIA protein
CTD PMID:15498850 PMID:22245093 PMID:23688403 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions
decreases activity
decreases expression
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of NOS2 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of NOS2 protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ochratoxin A results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of NOS2 protein
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of NOS2 mRNA
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[IFNG protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Bleomycin results in increased expression of NOS2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased expression of NOS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of NOS2 protein; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of NOS2 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of NOS2 mRNA]
CTD PMID:11457450 PMID:11890746 PMID:12847270 PMID:15684285 PMID:15994020 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 decreases activity EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of NOS3 protein CTD PMID:11890746 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 affects activity
multiple interactions
ISO 15-deoxy-delta(12,14)-prostaglandin J2 affects the activity of NR3C1 protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Dexamethasone binds to NR3C1 protein] which results in decreased expression of CCL2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Dexamethasone binds to NR3C1 protein]
CTD PMID:15187150 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Park7 Parkinsonism associated deglycase multiple interactions EXP 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in decreased expression of PARK7 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride results in decreased expression of PARK7 protein] CTD PMID:22245093 NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 results in increased cleavage of PARP1 protein
[delta(12)-prostaglandin J(2) co-treated with 9-deoxy-delta-9-prostaglandin D2 co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in increased cleavage of PARP1 protein
CTD PMID:15498850 PMID:23973622 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PCK1 mRNA CTD PMID:9518257 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PPARA protein CTD PMID:9013583 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PPARD protein CTD PMID:17341418 NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma affects expression
decreases response to substance
increases expression
increases activity
multiple interactions
decreases expression
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 affects the expression of PPARG
PPARG protein mutant form results in decreased susceptibility to 15-deoxy-delta(12,14)-prostaglandin J2
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PPARG mRNA; 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PPARG protein
15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in decreased expression of PPARG protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ochratoxin A results in increased expression of PPARG mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [PPARG protein affects the reaction [Lipopolysaccharides results in increased abundance of Nitric Oxide]]; MED1 protein promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]
15-deoxy-delta(12,14)-prostaglandin J2 affects the localization of and results in increased expression of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in decreased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased localization of and results in increased activity of PPARG protein; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [deoxynivalenol results in increased expression of PPARG protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Fatty Acids, Nonesterified results in decreased expression of PPARG mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in decreased expression of PPARG mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]; MG 262 promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of PPARG protein]; PPARG protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TBXA2R mRNA alternative form]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of PPARG protein
CTD PMID:9013583 PMID:10662598 PMID:11030710 PMID:12065695 PMID:12604364 More... NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in increased expression of PTEN protein CTD PMID:16611854 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgdr prostaglandin D2 receptor multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PTGDR protein; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 NCBI chr15:17,360,304...17,367,679 JBrowse link
G Ptgdr2 prostaglandin D2 receptor 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PTGDR2 protein; ramatroban inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 binds to and results in increased activity of PTGDR2 protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Prostaglandin D2 binds to PTGDR2 protein]
CTD PMID:12721327 PMID:16256979 NCBI chr 1:207,585,088...207,590,275
Ensembl chr 1:207,587,917...207,589,213
JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 multiple interactions ISO PTGS1 protein promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2] CTD PMID:17439952 NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased expression of PTGS2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of PTGS2 protein; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of and results in decreased expression of PTGS2 protein]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of PTGS2 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of PTGS2
CTD PMID:11457450 PMID:12604364 PMID:15254749 PMID:19997048 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 increases phosphorylation EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased phosphorylation of PTPN11 protein CTD PMID:12584205 NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased activity of and results in decreased phosphorylation of RAF1 protein CTD PMID:12083801 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rarb retinoic acid receptor, beta multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [ciglitazone promotes the reaction [SR 11237 results in increased expression of RARB protein]]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of RARB
CTD PMID:12839938 PMID:15254749 NCBI chr15:8,700,533...9,051,288
Ensembl chr15:8,406,492...9,051,288
JBrowse link
G Rb1 RB transcriptional corepressor 1 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased phosphorylation of and results in decreased expression of RB1 protein CTD PMID:15729575 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases activity
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein affects the localization of RELA protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL1B protein results in increased activity of [RELA protein binds to NFKB1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased activity of RELA protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased activity of RELA protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [manganese chloride affects the localization of RELA protein]
CTD PMID:11457450 PMID:15498850 PMID:20174873 PMID:22245093 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rps6ka1 ribosomal protein S6 kinase A1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of RPS6KA1 protein CTD PMID:16611854 NCBI chr 5:146,079,018...146,118,272
Ensembl chr 5:146,079,021...146,118,272
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO [15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of and results in decreased activity of RPS6KB1 protein; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased expression of TGFB1 mRNA]; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased phosphorylation of KLF6 protein] CTD PMID:16611854 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Runx2 RUNX family transcription factor 2 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of RUNX2 mRNA CTD PMID:12021203 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Rxra retinoid X receptor alpha increases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of RXRA CTD PMID:15254749 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of and results in increased secretion of SERPINE1 protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of SERPINE1 mRNA]] CTD PMID:18278065 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; SMAD2 protein modified form affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2]] CTD PMID:19429239 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
JBrowse link
G Socs1 suppressor of cytokine signaling 1 increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of SOCS1 mRNA CTD PMID:12584205 NCBI chr10:4,882,651...4,884,342
Ensembl chr10:4,882,560...4,884,383
JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of SOCS3 mRNA CTD PMID:12584205 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Spp1 secreted phosphoprotein 1 decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of SPP1 mRNA CTD PMID:12021203 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT1 protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased activity of and results in increased localization of [STAT1 protein binds to STAT1 protein]]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [peroxyvanadate results in increased phosphorylation of STAT1 protein]; Acetylcysteine inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; CAT protein inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Glutathione inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; Hydrogen Peroxide promotes the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]; peroxyvanadate inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IFNG protein results in increased phosphorylation of STAT1 protein]]
CTD PMID:12584205 PMID:12847270 NCBI chr 9:49,419,561...49,459,969 JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased expression of STAT3 protein]]; T 0070907 inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [LIF protein results in increased phosphorylation of STAT3 protein]]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT3 protein]
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [IL6 protein results in increased phosphorylation of STAT3 protein]
CTD PMID:12584205 PMID:12847270 PMID:19922793 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tbxa2r thromboxane A2 receptor multiple interactions
decreases expression
ISO PPARG protein affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TBXA2R mRNA alternative form] CTD PMID:16499875 NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176
JBrowse link
G Tg thyroglobulin multiple interactions
increases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [TSHB protein results in increased expression of TG protein]
15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of TG protein
CTD PMID:11078701 NCBI chr 7:98,418,293...98,603,210
Ensembl chr 7:98,418,293...98,603,210
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions
decreases expression
decreases response to substance
ISO
EXP
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of and results in increased secretion of CCN2 protein]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2 mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; SMAD2 protein modified form affects the reaction [15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [TGFB1 protein results in increased expression of CCN2]]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TGFB1 mRNA
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [AGT protein results in increased expression of TGFB1 protein]
15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [alitretinoin results in decreased expression of TGFB1 mRNA]; 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [[alitretinoin co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased expression of TGFB1 mRNA]; 2-chloro-5-nitrobenzanilide inhibits the reaction [[alitretinoin co-treated with 15-deoxy-delta(12,14)-prostaglandin J2] results in decreased expression of TGFB1 mRNA]; RPS6KB1 protein inhibits the reaction [[15-deoxy-delta(12,14)-prostaglandin J2 co-treated with alitretinoin] results in decreased expression of TGFB1 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased susceptibility to TGFB1 protein
CTD PMID:16611854 PMID:18278065 PMID:19429239 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Th tyrosine hydroxylase increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of TH protein CTD PMID:15212945 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tlr2 toll-like receptor 2 multiple interactions
decreases expression
ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of TLR2 mRNA]
15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TLR2 mRNA
CTD PMID:20174873 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of TNF protein
15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:12604364 PMID:19888466 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 promotes the reaction [TSHB protein results in increased expression of TG protein] CTD PMID:11078701 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Tslp thymic stromal lymphopoietin multiple interactions ISO 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP mRNA]; 15-deoxy-delta(12,14)-prostaglandin J2 inhibits the reaction [[Poly I-C co-treated with IL4 protein] results in increased expression of TSLP protein] CTD PMID:23688403 NCBI chr18:24,447,409...24,454,244
Ensembl chr18:24,449,844...24,453,548
JBrowse link
G Vim vimentin decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of VIM CTD PMID:15254749 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
JBrowse link
G Wnt10b Wnt family member 10B decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of WNT10B mRNA CTD PMID:12021203 NCBI chr 7:129,922,088...129,927,892
Ensembl chr 7:129,922,088...129,927,892
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO 15-deoxy-delta(12,14)-prostaglandin J2 results in decreased expression of XIAP protein CTD PMID:15498850 PMID:16299251 NCBI chr  X:120,890,537...120,938,413
Ensembl chr  X:120,897,907...120,934,700
JBrowse link
16,16-dimethylprostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation
multiple interactions
ISO 16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein
EGFR affects the reaction [16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein]
CTD PMID:15578100 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases response to substance
affects localization
ISO BAX results in increased susceptibility to 16,16-Dimethylprostaglandin E2
16,16-Dimethylprostaglandin E2 affects the localization of BAX protein
CTD PMID:15578100 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO EGFR affects the reaction [16,16-Dimethylprostaglandin E2 results in increased phosphorylation of AKT1 protein] CTD PMID:15578100 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Hpgd 15-hydroxyprostaglandin dehydrogenase increases activity ISO 16,16-Dimethylprostaglandin E2 results in increased activity of HPGD protein CTD PMID:14736730 NCBI chr16:33,986,265...34,024,228
Ensembl chr16:33,986,266...34,024,228
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of MPO protein] CTD PMID:11686837 PMID:11855677 PMID:11991626 PMID:18306037 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased activity of NOS2 protein]; 16,16-Dimethylprostaglandin E2 inhibits the reaction [Indomethacin results in increased expression of NOS2 mRNA] CTD PMID:11686837 PMID:11855677 PMID:11991626 PMID:15610444 PMID:18306037 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases expression
ISO
EXP
Flurbiprofen inhibits the reaction [16,16-Dimethylprostaglandin E2 results in increased expression of PTGS2 mRNA]
16,16-Dimethylprostaglandin E2 inhibits the reaction [SC 560 results in increased expression of PTGS2 mRNA]
CTD PMID:9099957 PMID:15610444 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 16,16-Dimethylprostaglandin E2 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF] CTD PMID:9298541 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
2-cyclopenten-1-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 multiple interactions ISO cyclopentenone results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:18383863 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO cyclopentenone results in increased expression of CDKN1B CTD PMID:16061222 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO cyclopentenone results in decreased phosphorylation of RB1 protein CTD PMID:16061222 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
2-methoxyestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hsd17b2 hydroxysteroid (17-beta) dehydrogenase 2 multiple interactions ISO [HSD17B2 protein results in increased metabolism of and results in decreased activity of 2-methoxyestradiol] which results in increased chemical synthesis of 2-methoxyestrone CTD PMID:16397246 NCBI chr19:45,753,576...45,825,203
Ensembl chr19:45,753,574...45,825,202
JBrowse link
28-deoxonimbolide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO 28-deoxonimbolide results in increased activity of CASP3 protein CTD PMID:21381696 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO 28-deoxonimbolide results in increased activity of CASP8 protein CTD PMID:21381696 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO 28-deoxonimbolide results in increased activity of CASP9 protein CTD PMID:21381696 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
4-Vinylcyclohexene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor increases expression EXP 4-vinylcyclohexene results in increased expression of AHR mRNA; 4-vinylcyclohexene results in increased expression of AHR protein CTD PMID:15710172 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Casp3 caspase 3 increases activity EXP 4-vinylcyclohexene results in increased activity of CASP3 protein CTD PMID:15710172 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases metabolic processing
EXP [CYP2B1 protein results in increased metabolism of 4-vinylcyclohexene] which results in increased abundance of 1,2-epoxy-4-vinylcyclohexane CTD PMID:11368546 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression
multiple interactions
increases metabolic processing
ISO
EXP
4-vinylcyclohexene results in increased expression of CYP2E1 protein
[CYP2E1 protein results in increased metabolism of 4-vinylcyclohexene] which results in increased abundance of 1,2-epoxy-4-vinylcyclohexane
CTD PMID:9929517 PMID:11368546 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
AH23848 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to AKT1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of AKT1 protein CTD PMID:19407222 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Arrb1 arrestin, beta 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to IL1R1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to TNFRSF1A protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [ARRB1 protein modified form binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of ARRB1 protein CTD PMID:19407222 NCBI chr 1:153,837,964...153,912,111
Ensembl chr 1:153,838,078...153,904,061
JBrowse link
G Axin1 axin 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [AXIN1 protein binds to CTNNB1 protein] CTD PMID:19407222 NCBI chr10:15,163,684...15,215,615
Ensembl chr10:15,163,684...15,215,615
JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAD protein binds to BCL2 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAD protein binds to BCL2L1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of BAD protein CTD PMID:19407222 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAX protein binds to BCL2 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAX protein binds to BCL2L1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in increased expression of BAX protein CTD PMID:19407222 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAD protein binds to BCL2 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAX protein binds to BCL2 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of BCL2 protein CTD PMID:19407222 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAD protein binds to BCL2L1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [BAX protein binds to BCL2L1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of BCL2L1 protein CTD PMID:19407222 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp3 caspase 3 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in increased cleavage of and results in increased activity of CASP3 protein
AH 23848 inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased cleavage of CASP3 protein]
CTD PMID:19407222 PMID:32115946 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [AXIN1 protein binds to CTNNB1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [GSK3B protein binds to CTNNB1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in increased degradation of CTNNB1 protein CTD PMID:19407222 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions ISO AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]; AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]; AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 mRNA]; AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein] CTD PMID:20678559 PMID:28571770 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO AH 23848 inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; AH 23848 inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein] CTD PMID:20093341 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [EGFR protein modified form binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of and results in decreased expression of EGFR protein CTD PMID:19407222 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Egr1 early growth response 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of EGR1 protein CTD PMID:19407222 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of FOS protein CTD PMID:19407222 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to AKT1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to MAPK1 protein binds to MAPK3 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] promotes the reaction [GSK3B protein binds to CTNNB1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of GSK3B protein CTD PMID:19407222 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Il1r1 interleukin 1 receptor type 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to IL1R1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of IL1R1 protein CTD PMID:19407222 NCBI chr 9:42,504,917...42,580,958
Ensembl chr 9:42,504,735...42,579,937
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of JUN protein CTD PMID:19407222 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Lep leptin multiple interactions ISO AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]; AH 23848 inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] CTD PMID:28571770 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to MAPK1 protein binds to MAPK3 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of MAPK1 protein CTD PMID:19407222 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [GSK3B protein binds to MAPK1 protein binds to MAPK3 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of MAPK3 protein CTD PMID:19407222 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of MYC protein CTD PMID:19407222 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of NFKB1 protein CTD PMID:19407222 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of NFKBIA protein CTD PMID:19407222 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in increased cleavage of and results in increased activity of PARP1 protein CTD PMID:19407222 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Ptger2 prostaglandin E receptor 2 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [PTGER2 protein binds to SRC protein] CTD PMID:19407222 NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714
JBrowse link
G Ptger4 prostaglandin E receptor 4 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [PTGER4 protein binds to SRC protein] CTD PMID:19407222 NCBI chr 2:54,330,563...54,347,451
Ensembl chr 2:54,335,424...54,346,670
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; AH 23848 inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein] CTD PMID:20678559 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of and results in decreased expression of RELA protein CTD PMID:19407222 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of SP1 protein CTD PMID:19407222 NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to IL1R1 protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to TNFRSF1A protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [ARRB1 protein modified form binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [EGFR protein modified form binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [PTGER2 protein binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [PTGER4 protein binds to SRC protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased phosphorylation of SRC protein CTD PMID:19407222 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Tcf7 transcription factor 7 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of TCF7 protein CTD PMID:19407222 NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535
JBrowse link
G Tcf7l2 transcription factor 7 like 2 multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of TCF7L2 protein CTD PMID:19407222 NCBI chr 1:254,785,956...254,978,967
Ensembl chr 1:254,786,091...254,978,967
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO AH 23848 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF] CTD PMID:9298541 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] inhibits the reaction [[ARRB1 protein modified form binds to SRC protein] which binds to TNFRSF1A protein]; [6-isopropoxy-9-oxoxanthene-2-carboxylic acid co-treated with AH 23848] results in decreased expression of TNFRSF1A protein CTD PMID:19407222 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
alpha-hexachlorocyclohexane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb4 ATP binding cassette subfamily B member 4 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ABCB4 mRNA CTD PMID:16940010 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ABCC3 mRNA CTD PMID:17785943 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Acaa2 acetyl-CoA acyltransferase 2 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of ACAA2 mRNA CTD PMID:16940010 NCBI chr18:68,345,136...68,373,246
Ensembl chr18:68,345,012...68,373,249
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ACAT2 mRNA CTD PMID:17785943 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
JBrowse link
G Adap2 ArfGAP with dual PH domains 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ADAP2 mRNA CTD PMID:16940010 NCBI chr10:65,138,006...65,166,147
Ensembl chr10:65,138,020...65,165,604
JBrowse link
G Adh1 alcohol dehydrogenase 1 (class I) decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of ADH1 mRNA CTD PMID:16940010 NCBI chr 2:226,797,303...226,808,892
Ensembl chr 2:226,797,303...226,808,892
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ALDH1A1 mRNA CTD PMID:17785943 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Apoc1 apolipoprotein C1 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of APOC1 mRNA CTD PMID:16940010 NCBI chr 1:79,347,057...79,350,340
Ensembl chr 1:79,346,136...79,350,375
JBrowse link
G App amyloid beta precursor protein increases expression EXP alpha-hexachlorocyclohexane results in increased expression of APP mRNA CTD PMID:17785943 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Ar androgen receptor multiple interactions ISO alpha-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; alpha-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; alpha-hexachlorocyclohexane inhibits the reaction [Metribolone results in increased activity of AR protein] CTD PMID:10696776 PMID:15084347 PMID:21962538 PMID:26022396 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of CA3 mRNA CTD PMID:16940010 PMID:17785943 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Car2 carbonic anhydrase 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CA2 mRNA CTD PMID:17785943 NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818
JBrowse link
G Casp3 caspase 3 increases activity ISO alpha-hexachlorocyclohexane results in increased activity of CASP3 protein CTD PMID:19818741 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions
increases activity
EXP [Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of CAT protein
alpha-hexachlorocyclohexane results in increased activity of CAT protein
CTD PMID:1708174 PMID:16046044 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cbx1 chromobox 1 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of CBX1 mRNA CTD PMID:16940010 NCBI chr10:81,770,307...81,789,981
Ensembl chr10:81,770,342...81,791,096
JBrowse link
G Cd36 CD36 molecule increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CD36 mRNA CTD PMID:17785943 NCBI chr 4:17,317,343...17,410,084 JBrowse link
G Cdc123 cell division cycle 123 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CDC123 mRNA CTD PMID:16940010 NCBI chr17:72,459,296...72,502,948
Ensembl chr17:72,459,282...72,503,316
JBrowse link
G Cdk17 cyclin-dependent kinase 17 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of CDK17 mRNA CTD PMID:16940010 NCBI chr 7:27,683,890...27,765,814
Ensembl chr 7:27,683,890...27,764,910
JBrowse link
G Ces2h carboxylesterase 2H increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CES2 mRNA CTD PMID:17785943 NCBI chr19:32,974,242...32,988,842
Ensembl chr19:32,974,242...32,988,830
JBrowse link
G Chchd2 coiled-coil-helix-coiled-coil-helix domain containing 2 affects expression
decreases expression
increases expression
EXP alpha-hexachlorocyclohexane affects the expression of CHCHD2 mRNA
alpha-hexachlorocyclohexane results in decreased expression of CHCHD2 mRNA
alpha-hexachlorocyclohexane results in increased expression of CHCHD2 mRNA
CTD PMID:16940010 NCBI chr 9:94,500,439...94,501,110
Ensembl chr 9:94,500,432...94,501,128
JBrowse link
G Cpn1 carboxypeptidase N subunit 1 affects expression
increases expression
decreases expression
EXP alpha-hexachlorocyclohexane affects the expression of CPN1 mRNA
alpha-hexachlorocyclohexane results in increased expression of CPN1 mRNA
alpha-hexachlorocyclohexane results in decreased expression of CPN1 mRNA
CTD PMID:16940010 NCBI chr 1:242,844,575...242,873,465
Ensembl chr 1:242,844,212...242,873,465
JBrowse link
G Ctsc cathepsin C decreases expression
increases expression
affects expression
EXP alpha-hexachlorocyclohexane results in decreased expression of CTSC mRNA
alpha-hexachlorocyclohexane results in increased expression of CTSC mRNA
alpha-hexachlorocyclohexane affects the expression of CTSC mRNA
CTD PMID:16940010 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
JBrowse link
G Cyb5a cytochrome b5 type A affects expression EXP alpha-hexachlorocyclohexane affects the expression of CYB5A mRNA CTD PMID:17785943 NCBI chr18:78,213,067...78,245,677
Ensembl chr18:78,202,342...78,258,535
Ensembl chr18:78,202,342...78,258,535
JBrowse link
G Cyb5r3 cytochrome b5 reductase 3 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYB5R3 mRNA CTD PMID:17785943 NCBI chr 7:114,306,686...114,324,247
Ensembl chr 7:114,306,685...114,324,298
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP1A1 protein CTD PMID:11165752 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP2A1 protein CTD PMID:16246485 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 multiple interactions
increases activity
EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP2B1 protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2B1 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2B1 protein
alpha-hexachlorocyclohexane results in increased activity of CYP2B1 protein
CTD PMID:1372805 PMID:11165752 PMID:16246485 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYP2B15 mRNA CTD PMID:17785943 NCBI chr 1:82,094,188...82,106,492
Ensembl chr 1:82,094,180...82,106,492
JBrowse link
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYP2B2 mRNA CTD PMID:16940010 PMID:17785943 NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C11 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C11 protein CTD PMID:16246485 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of CYP2C12 mRNA CTD PMID:17785943 NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 increases expression
multiple interactions
EXP alpha-hexachlorocyclohexane results in increased expression of CYP2C6V1 mRNA
[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2C6V1 protein
CTD PMID:16246485 PMID:16940010 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP2E1 protein CTD PMID:16246485 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
multiple interactions
EXP alpha-hexachlorocyclohexane results in increased expression of CYP3A2 mRNA
[Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of CYP3A2 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased activity of CYP3A2 protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 mRNA; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of CYP3A2 protein
CTD PMID:11165752 PMID:16246485 PMID:16940010 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYP3A23-3A1 mRNA CTD PMID:16940010 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Cyp4a8 cytochrome P450, family 4, subfamily a, polypeptide 8 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYP4A8 mRNA CTD PMID:17785943 NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476
JBrowse link
G Cyp51 cytochrome P450, family 51 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of CYP51 mRNA CTD PMID:17785943 NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 decreases expression
increases expression
affects expression
EXP alpha-hexachlorocyclohexane results in decreased expression of ECI1 mRNA
alpha-hexachlorocyclohexane results in increased expression of ECI1 mRNA
alpha-hexachlorocyclohexane affects the expression of ECI1 mRNA
CTD PMID:16940010 NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061
JBrowse link
G Egf epidermal growth factor multiple interactions EXP [EGF protein co-treated with alpha-hexachlorocyclohexane] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Epcam epithelial cell adhesion molecule increases expression EXP alpha-hexachlorocyclohexane results in increased expression of EPCAM mRNA CTD PMID:17785943 NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
JBrowse link
G Ephx1 epoxide hydrolase 1 increases expression
increases activity
EXP alpha-hexachlorocyclohexane results in increased expression of EPHX1 mRNA
alpha-hexachlorocyclohexane results in increased activity of EPHX1 protein
CTD PMID:1372805 PMID:16940010 NCBI chr13:92,714,315...92,744,124
Ensembl chr13:92,714,315...92,790,235
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases activity
EXP
ISO
alpha-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein]
alpha-hexachlorocyclohexane results in increased activity of ESR1 protein
CTD PMID:10580743 PMID:26022396 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO alpha-hexachlorocyclohexane results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fev FEV transcription factor, ETS family member decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of FEV mRNA CTD PMID:17785943 NCBI chr 9:76,439,164...76,443,603
Ensembl chr 9:76,439,172...76,443,065
JBrowse link
G Fgf1 fibroblast growth factor 1 decreases response to substance EXP alpha-hexachlorocyclohexane results in decreased susceptibility to FGF1 protein CTD PMID:1715812 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fkbp3 FKBP prolyl isomerase 3 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of FKBP3 mRNA CTD PMID:17785943 NCBI chr 6:83,113,885...83,125,500
Ensembl chr 6:83,113,786...83,127,011
JBrowse link
G Fn1 fibronectin 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of FN1 mRNA CTD PMID:17785943 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP alpha-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA] CTD PMID:1380685 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Ftl1 ferritin light chain 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of FTL1 mRNA CTD PMID:16940010 NCBI chr 1:95,936,390...95,938,234
Ensembl chr 1:95,936,387...95,939,725
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 decreases expression
multiple interactions
EXP
ISO
alpha-hexachlorocyclohexane results in decreased expression of GABRA1 mRNA
alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]
CTD PMID:9316872 PMID:17785943 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions ISO alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:9316872 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO alpha-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; alpha-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]] CTD PMID:9316872 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase affects expression
decreases expression
increases expression
EXP alpha-hexachlorocyclohexane affects the expression of GAPDH mRNA
alpha-hexachlorocyclohexane results in decreased expression of GAPDH mRNA
alpha-hexachlorocyclohexane results in increased expression of GAPDH mRNA
CTD PMID:16940010 NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
JBrowse link
G Gpx2 glutathione peroxidase 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of GPX2 mRNA CTD PMID:17785943 NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877
JBrowse link
G Gsr glutathione-disulfide reductase increases expression
multiple interactions
EXP alpha-hexachlorocyclohexane results in increased expression of GSR mRNA
[Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of GSR protein
CTD PMID:16046044 PMID:17785943 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta2 glutathione S-transferase alpha 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of GSTA2 mRNA CTD PMID:16940010 PMID:17785943 NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798
JBrowse link
G Gsta5 glutathione S-transferase alpha 5 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of GSTA5 mRNA CTD PMID:17785943 NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of GSTK1 mRNA CTD PMID:16940010 NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292
JBrowse link
G Gstm4 glutathione S-transferase mu 4 decreases expression
increases expression
affects expression
EXP alpha-hexachlorocyclohexane results in decreased expression of GSTM4 mRNA
alpha-hexachlorocyclohexane results in increased expression of GSTM4 mRNA
alpha-hexachlorocyclohexane affects the expression of GSTM4 mRNA
CTD PMID:16940010 NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323
JBrowse link
G Gstp1 glutathione S-transferase pi 1 multiple interactions
increases expression
EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of GSTP1 protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of GSTP1 protein
alpha-hexachlorocyclohexane results in increased expression of GSTP1 mRNA
CTD PMID:16246485 PMID:16940010 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Hgf hepatocyte growth factor increases expression EXP alpha-hexachlorocyclohexane results in increased expression of HGF protein CTD PMID:1370768 NCBI chr 4:18,673,736...18,745,582
Ensembl chr 4:18,677,101...18,745,409
JBrowse link
G Hspb1 heat shock protein family B (small) member 1 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of HSPB1 mRNA CTD PMID:17785943 NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743
JBrowse link
G Kcnj5 potassium inwardly-rectifying channel, subfamily J, member 5 affects expression EXP alpha-hexachlorocyclohexane affects the expression of KCNJ5 mRNA CTD PMID:17785943 NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518
JBrowse link
G Kit KIT proto-oncogene receptor tyrosine kinase increases expression EXP alpha-hexachlorocyclohexane results in increased expression of KIT mRNA CTD PMID:16940010 NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652
JBrowse link
G Lpl lipoprotein lipase increases expression EXP alpha-hexachlorocyclohexane results in increased expression of LPL mRNA CTD PMID:17785943 NCBI chr16:20,830,055...20,853,855
Ensembl chr16:20,829,465...20,855,249
JBrowse link
G Lrp2 LDL receptor related protein 2 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of LRP2 mRNA CTD PMID:16940010 NCBI chr 3:54,189,305...54,346,769
Ensembl chr 3:54,189,308...54,346,708
JBrowse link
G Luc7l2 LUC7-like 2 pre-mRNA splicing factor affects expression EXP alpha-hexachlorocyclohexane affects the expression of LUC7L2 mRNA CTD PMID:17785943 NCBI chr 4:67,287,593...67,347,986
Ensembl chr 4:67,287,640...67,347,964
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases expression
affects expression
decreases expression
EXP alpha-hexachlorocyclohexane results in increased expression of MAPK1 mRNA
alpha-hexachlorocyclohexane affects the expression of MAPK1 mRNA
alpha-hexachlorocyclohexane results in decreased expression of MAPK1 mRNA
CTD PMID:16940010 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk6 mitogen-activated protein kinase 6 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of MAPK6 mRNA CTD PMID:16940010 NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720
JBrowse link
G Me1 malic enzyme 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of ME1 mRNA CTD PMID:17785943 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Meox2 mesenchyme homeobox 2 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of MEOX2 mRNA CTD PMID:17785943 NCBI chr 6:53,856,760...53,917,467
Ensembl chr 6:53,856,758...53,917,467
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression EXP alpha-hexachlorocyclohexane results in increased expression of COX1 mRNA CTD PMID:16940010 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Muc13 mucin 13, cell surface associated decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of MUC13 mRNA CTD PMID:17785943 NCBI chr11:66,957,208...66,980,264
Ensembl chr11:66,960,595...66,984,727
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor multiple interactions EXP [EGF protein co-treated with alpha-hexachlorocyclohexane] results in increased expression of MYC mRNA CTD PMID:12632255 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions
increases expression
ISO Acetylcysteine inhibits the reaction [alpha-hexachlorocyclohexane results in increased expression of NCF1 mRNA] CTD PMID:28273962 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Ncl nucleolin increases expression EXP alpha-hexachlorocyclohexane results in increased expression of NCL mRNA CTD PMID:17785943 NCBI chr 9:86,999,588...87,008,112
Ensembl chr 9:86,998,019...87,008,136
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression
multiple interactions
ISO alpha-hexachlorocyclohexane results in increased expression of NOS3 mRNA
Acetylcysteine inhibits the reaction [alpha-hexachlorocyclohexane results in increased expression of NOS3 mRNA]
CTD PMID:28273962 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of NQO1 mRNA CTD PMID:16940010 PMID:17785943 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity
ISO alpha-hexachlorocyclohexane binds to and results in increased activity of NR1I2 protein
alpha-hexachlorocyclohexane results in increased activity of NR1I2 protein
CTD PMID:21115097 PMID:25680588 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of OGG1 mRNA CTD PMID:16246485 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Onecut1 one cut homeobox 1 affects expression EXP alpha-hexachlorocyclohexane affects the expression of ONECUT1 mRNA CTD PMID:17785943 NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in decreased expression of PCNA protein; [Diethylnitrosamine co-treated with alpha-hexachlorocyclohexane] results in increased expression of PCNA protein CTD PMID:16246485 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Pgr progesterone receptor multiple interactions ISO alpha-hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein] CTD PMID:26022396 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of PPP2R2B mRNA CTD PMID:17785943 NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025
JBrowse link
G Prss8 serine protease 8 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of PRSS8 mRNA CTD PMID:17785943 NCBI chr 1:182,536,229...182,540,745
Ensembl chr 1:182,536,229...182,540,815
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of PSAT1 mRNA CTD PMID:17785943 NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
JBrowse link
G Psmc3 proteasome 26S subunit, ATPase 3 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of PSMC3 mRNA CTD PMID:16940010 NCBI chr 3:77,031,825...77,037,207
Ensembl chr 3:77,031,825...77,043,358
JBrowse link
G Psme1 proteasome activator subunit 1 decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of PSME1 mRNA CTD PMID:16940010 NCBI chr15:29,069,012...29,071,888
Ensembl chr15:29,068,729...29,071,890
JBrowse link
G Rab7a RAB7A, member RAS oncogene family increases expression EXP alpha-hexachlorocyclohexane results in increased expression of RAB7 mRNA CTD PMID:17785943 NCBI chr 4:120,461,966...120,510,756
Ensembl chr 4:120,461,963...120,506,889
JBrowse link
G Rb1 RB transcriptional corepressor 1 affects expression
increases expression
decreases expression
EXP alpha-hexachlorocyclohexane affects the expression of RB1 mRNA
alpha-hexachlorocyclohexane results in increased expression of RB1 mRNA
alpha-hexachlorocyclohexane results in decreased expression of RB1 mRNA
CTD PMID:16940010 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rnpep arginyl aminopeptidase decreases expression
increases expression
affects expression
EXP alpha-hexachlorocyclohexane results in decreased expression of RNPEP mRNA
alpha-hexachlorocyclohexane results in increased expression of RNPEP mRNA
alpha-hexachlorocyclohexane affects the expression of RNPEP mRNA
CTD PMID:16940010 NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998
JBrowse link
G Rplp0 ribosomal protein lateral stalk subunit P0 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of RPLP0 mRNA CTD PMID:16940010 NCBI chr12:41,054,363...41,057,632
Ensembl chr12:41,054,179...41,057,632
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of SCD1 mRNA CTD PMID:17785943 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Slc16a1 solute carrier family 16 member 1 affects expression
increases expression
decreases expression
EXP alpha-hexachlorocyclohexane affects the expression of SLC16A1 mRNA
alpha-hexachlorocyclohexane results in increased expression of SLC16A1 mRNA
alpha-hexachlorocyclohexane results in decreased expression of SLC16A1 mRNA
CTD PMID:16940010 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
JBrowse link
G Slc17a1 solute carrier family 17 member 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of SLC17A1 mRNA CTD PMID:17785943 NCBI chr17:41,219,461...41,255,199 JBrowse link
G Smpx small muscle protein, X-linked decreases expression EXP alpha-hexachlorocyclohexane results in decreased expression of SMPX mRNA CTD PMID:17785943 NCBI chr  X:37,233,209...37,292,266
Ensembl chr  X:37,234,294...37,276,708
JBrowse link
G Snx4 sorting nexin 4 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of SNX4 mRNA CTD PMID:17785943 NCBI chr11:67,460,872...67,518,143
Ensembl chr11:67,460,870...67,518,174
JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions ISO alpha-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR mRNA]; alpha-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR protein] CTD PMID:10993823 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Suclg2 succinate-CoA ligase GDP-forming subunit beta increases expression EXP alpha-hexachlorocyclohexane results in increased expression of SUCLG2 mRNA CTD PMID:16940010 NCBI chr 4:128,067,031...128,337,146
Ensembl chr 4:128,067,033...128,337,170
JBrowse link
G Sult1b1 sulfotransferase family 1B member 1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of SULT1B1 mRNA CTD PMID:16940010 NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483
JBrowse link
G Tp53 tumor protein p53 increases expression
affects expression
decreases expression
EXP alpha-hexachlorocyclohexane results in increased expression of TP53 mRNA
alpha-hexachlorocyclohexane affects the expression of TRP53 mRNA
alpha-hexachlorocyclohexane results in decreased expression of TP53 mRNA
CTD PMID:16940010 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Ubc ubiquitin C increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UBC mRNA CTD PMID:16940010 NCBI chr12:31,238,889...31,243,924
Ensembl chr12:31,239,152...31,243,925
JBrowse link
G Ugt1a3 UDP glycosyltransferase 1 family, polypeptide A3 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT1A5 mRNA CTD PMID:17785943 NCBI chr 9:88,780,328...88,808,465 JBrowse link
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT1A6 mRNA CTD PMID:17785943 NCBI chr 9:88,747,229...88,808,465 JBrowse link
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT1A7 mRNA CTD PMID:16940010 NCBI chr 9:88,739,577...88,808,465 JBrowse link
G Ugt2a1 UDP glucuronosyltransferase family 2 member A1 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT2A1 mRNA CTD PMID:16940010 NCBI chr14:20,521,018...20,545,060
Ensembl chr14:20,517,951...20,545,531
JBrowse link
G Ugt2b UDP glycosyltransferase 2 family, polypeptide B increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT2B mRNA CTD PMID:16940010 NCBI chr14:20,630,572...20,665,062
Ensembl chr14:20,630,250...20,651,776
JBrowse link
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 increases expression EXP alpha-hexachlorocyclohexane results in increased expression of UGT2B1 mRNA CTD PMID:16940010 PMID:17785943 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986
JBrowse link
G Vip vasoactive intestinal peptide multiple interactions EXP alpha-hexachlorocyclohexane inhibits the reaction [VIP protein results in increased abundance of Cyclic AMP] CTD PMID:2467674 NCBI chr 1:42,064,878...42,073,219
Ensembl chr 1:42,065,120...42,073,216
JBrowse link
azadiradione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 increases activity ISO azadiradione results in increased activity of CASP3 protein CTD PMID:21381696 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO azadiradione results in increased activity of CASP8 protein CTD PMID:21381696 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO azadiradione results in increased activity of CASP9 protein CTD PMID:21381696 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A increases expression ISO azadiradione results in increased expression of HSPA1A mRNA CTD PMID:30309986
Bardoxolone methyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adra1b adrenoceptor alpha 1B decreases activity ISO bardoxolone methyl results in decreased activity of ADRA1B protein CTD PMID:28790194 NCBI chr10:28,255,025...28,373,418
Ensembl chr10:28,255,025...28,312,919
JBrowse link
G Adra2c adrenoceptor alpha 2C decreases activity ISO bardoxolone methyl results in decreased activity of ADRA2C protein CTD PMID:28790194 NCBI chr14:75,471,143...75,472,846
Ensembl chr14:75,471,143...75,472,846
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased phosphorylation of AKT1 protein] CTD PMID:27417254 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Arg1 arginase 1 multiple interactions ISO bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of ARG1 mRNA] CTD PMID:26918785 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Aurkb aurora kinase B decreases activity ISO bardoxolone methyl results in decreased activity of AURKB protein CTD PMID:28790194 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases activity ISO bardoxolone methyl results in decreased activity of AVPR1A protein CTD PMID:28790194 NCBI chr 7:58,114,306...58,118,230
Ensembl chr 7:58,114,284...58,122,215
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions ISO bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased expression of BDNF protein] CTD PMID:27417254 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C decreases activity ISO bardoxolone methyl results in decreased activity of CACNA1C protein CTD PMID:28790194 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Casp8 caspase 8 decreases expression ISO bardoxolone methyl results in decreased expression of CASP8 protein CTD PMID:25246272 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 multiple interactions ISO bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL11 protein] CTD PMID:26918785 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL2 protein] CTD PMID:26918785 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL3 protein] CTD PMID:26918785 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
JBrowse link
G Ccl4 C-C motif chemokine ligand 4 multiple interactions ISO bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL4 protein] CTD PMID:26918785 NCBI chr10:68,466,469...68,467,941
Ensembl chr10:68,452,052...68,468,231
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CCL5 protein] CTD PMID:26918785 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccr5 C-C motif chemokine receptor 5 multiple interactions ISO bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of CCR5 mRNA] CTD PMID:26918785 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
JBrowse link
G Cd163 CD163 molecule multiple interactions ISO bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of CD163 mRNA]; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of CD163 protein] CTD PMID:26918785 NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878
JBrowse link
G Chrm1 cholinergic receptor, muscarinic 1 decreases activity ISO bardoxolone methyl results in decreased activity of CHRM1 protein CTD PMID:28790194 NCBI chr 1:205,567,046...205,583,001
Ensembl chr 1:205,567,220...205,582,356
JBrowse link
G Chrm2 cholinergic receptor, muscarinic 2 decreases activity ISO bardoxolone methyl results in decreased activity of CHRM2 protein CTD PMID:28790194 NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103
JBrowse link
G Clec10a C-type lectin domain containing 10A multiple interactions ISO bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of CLEC10A mRNA] CTD PMID:26918785 NCBI chr10:54,876,244...54,880,439
Ensembl chr10:54,876,260...54,880,435
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CXCL2 protein] CTD PMID:26918785 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Drd1 dopamine receptor D1 decreases activity ISO bardoxolone methyl results in decreased activity of DRD1 protein CTD PMID:28790194 NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002
JBrowse link
G Drd2 dopamine receptor D2 decreases activity ISO bardoxolone methyl results in decreased activity of DRD2 protein CTD PMID:28790194 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Fasn fatty acid synthase decreases expression ISO bardoxolone methyl results in decreased expression of FASN mRNA CTD PMID:20372807 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fmo2 flavin containing dimethylaniline monoxygenase 2 increases expression ISO bardoxolone methyl results in increased expression of FMO2 mRNA CTD PMID:25056779 NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308
JBrowse link
G Foxo1 forkhead box O1 multiple interactions ISO bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of and results in decreased phosphorylation of FOXO1 protein] CTD PMID:27417254 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression ISO bardoxolone methyl results in increased expression of GCLC mRNA; bardoxolone methyl results in increased expression of GCLC protein CTD PMID:27480280 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression ISO bardoxolone methyl results in increased expression of GCLM CTD PMID:21723306 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions
increases phosphorylation
ISO GSK3B protein mutant form inhibits the reaction [bardoxolone methyl results in increased expression of HMOX1 protein]; GSK3B protein mutant form inhibits the reaction [bardoxolone methyl results in increased phosphorylation of GSK3B protein] CTD PMID:25246272 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO GSK3B protein mutant form inhibits the reaction [bardoxolone methyl results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [bardoxolone methyl results in increased expression of HMOX1 protein]
bardoxolone methyl results in increased expression of HMOX1 mRNA; bardoxolone methyl results in increased expression of HMOX1 protein
[bardoxolone methyl co-treated with aristolochic acid I] results in increased expression of HMOX1 mRNA; bardoxolone methyl promotes the reaction [aristolochic acid I results in increased expression of HMOX1 protein]
CTD PMID:21289052 PMID:24530882 PMID:25246272 PMID:28790194 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hrh1 histamine receptor H 1 decreases activity ISO bardoxolone methyl results in decreased activity of HRH1 protein CTD PMID:28790194 NCBI chr 4:147,564,781...147,649,353
Ensembl chr 4:147,645,995...147,647,455
JBrowse link
G Htr2a 5-hydroxytryptamine receptor 2A decreases activity ISO bardoxolone methyl results in decreased activity of HTR2A protein CTD PMID:28790194 NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
JBrowse link
G Htr2c 5-hydroxytryptamine receptor 2C decreases activity ISO bardoxolone methyl results in decreased activity of HTR2C protein CTD PMID:28790194 NCBI chr  X:110,640,777...110,870,288
Ensembl chr  X:110,641,153...110,870,287
JBrowse link
G Ifng interferon gamma multiple interactions ISO bardoxolone methyl inhibits the reaction [IFNG protein results in increased expression of NOS2] CTD PMID:17363558 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL10 protein]; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA] CTD PMID:26918785 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il17a interleukin 17A multiple interactions ISO bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL17A protein] CTD PMID:26918785 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il6 interleukin 6 multiple interactions ISO bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of IL6 protein]; bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein] CTD PMID:26918785 PMID:27417254 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Ins2 insulin 2 multiple interactions ISO bardoxolone methyl inhibits the reaction [INS protein results in increased phosphorylation of RPS6 protein] CTD PMID:28790194 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Irf5 interferon regulatory factor 5 multiple interactions ISO bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of IRF5 mRNA] CTD PMID:26918785 NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267
JBrowse link
G Jak2 Janus kinase 2 multiple interactions ISO bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased phosphorylation of JAK2 protein] CTD PMID:27417254 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 increases expression
multiple interactions
ISO bardoxolone methyl results in increased expression of KEAP1 protein
bardoxolone methyl inhibits the reaction [aristolochic acid I results in increased expression of KEAP1 protein]
CTD PMID:24530882 PMID:27358234 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Lep leptin multiple interactions ISO bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased susceptibility to LEP protein]; bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of LEP protein] CTD PMID:27417254 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lif LIF, interleukin 6 family cytokine multiple interactions ISO bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of LIF protein] CTD PMID:26918785 NCBI chr14:79,131,049...79,140,486
Ensembl chr14:79,134,574...79,140,482
JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of MRC1 protein] CTD PMID:26918785 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 increases expression
multiple interactions
increases localization
decreases response to substance
increases activity
ISO
EXP
bardoxolone methyl results in increased expression of NFE2L2 mRNA; bardoxolone methyl results in increased expression of NFE2L2 protein
bardoxolone methyl inhibits the reaction [aristolochic acid I results in decreased expression of and affects the localization of NFE2L2 protein]; bardoxolone methyl inhibits the reaction [aristolochic acid I results in decreased expression of NFE2L2 mRNA]
bardoxolone methyl results in increased localization of NFE2L2 protein
NFE2L2 gene mutant form results in decreased susceptibility to bardoxolone methyl
NFE2L2 promotes the reaction [bardoxolone methyl results in increased expression of SRXN1 protein]; NFE2L2 protein affects the reaction [bardoxolone methyl results in increased expression of HMOX1 protein]
bardoxolone methyl results in increased activity of NFE2L2 protein
CTD PMID:21289052 PMID:21723306 PMID:24530882 PMID:24798383 PMID:25246272 More... NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased expression of NFKBIA protein] CTD PMID:25637688 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO bardoxolone methyl inhibits the reaction [IFNG protein results in increased expression of NOS2] CTD PMID:17363558 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 increases expression
increases activity
multiple interactions
ISO bardoxolone methyl results in increased expression of NQO1 mRNA; bardoxolone methyl results in increased expression of NQO1 protein
bardoxolone methyl results in increased activity of NQO1 protein
[bardoxolone methyl co-treated with aristolochic acid I] results in increased expression of NQO1 mRNA; [bardoxolone methyl co-treated with aristolochic acid I] results in increased expression of NQO1 protein
CTD PMID:24530882 PMID:27480280 PMID:28790194 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Oprk1 opioid receptor, kappa 1 decreases activity ISO bardoxolone methyl results in decreased activity of OPRK1 protein CTD PMID:28790194 NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823
JBrowse link
G Oprm1 opioid receptor, mu 1 decreases activity ISO bardoxolone methyl results in decreased activity of OPRM1 protein CTD PMID:28790194 NCBI chr 1:43,160,057...43,413,409
Ensembl chr 1:43,160,057...43,413,409
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO bardoxolone methyl results in increased cleavage of PARP1 protein CTD PMID:17363558 PMID:25246272 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pde4b phosphodiesterase 4B decreases activity ISO bardoxolone methyl results in decreased activity of PDE4B protein CTD PMID:28790194 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO bardoxolone methyl results in increased expression of PPARG mRNA; bardoxolone methyl results in increased expression of PPARG protein CTD PMID:21289052 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of PTPN1 protein] CTD PMID:27417254 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Rps6 ribosomal protein S6 multiple interactions ISO bardoxolone methyl inhibits the reaction [INS protein results in increased phosphorylation of RPS6 protein] CTD PMID:28790194 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Slc47a1 solute carrier family 47 member 1 increases expression ISO bardoxolone methyl results in increased expression of SLC47A1 mRNA; bardoxolone methyl results in increased expression of SLC47A1 protein CTD PMID:27480280 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions ISO bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA] CTD PMID:26918785 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression
multiple interactions
ISO bardoxolone methyl results in increased expression of SRXN1 protein
NFE2L2 promotes the reaction [bardoxolone methyl results in increased expression of SRXN1 protein]
CTD PMID:27358234 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions
decreases phosphorylation
ISO [bardoxolone methyl co-treated with Dietary Fats] results in decreased expression of STAT3 protein; bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of STAT3 protein]
bardoxolone methyl results in decreased phosphorylation of STAT3 protein
CTD PMID:17363558 PMID:25637688 PMID:27417254 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tacr1 tachykinin receptor 1 decreases activity ISO bardoxolone methyl results in decreased activity of TACR1 protein CTD PMID:28790194 NCBI chr 4:114,920,844...115,089,733
Ensembl chr 4:114,920,844...115,089,733
JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased phosphorylation of TH protein] CTD PMID:25637688 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Thrsp thyroid hormone responsive decreases expression ISO bardoxolone methyl results in decreased expression of THRSP mRNA CTD PMID:20372807 NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
[bardoxolone methyl co-treated with Dietary Fats] results in decreased expression of TNF protein; bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of TNF protein]; bardoxolone methyl inhibits the reaction [Dietary Fats results in increased expression of TNF]; bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; bardoxolone methyl promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
CTD PMID:25637688 PMID:26612656 PMID:26918785 PMID:27417254 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Ucp2 uncoupling protein 2 multiple interactions ISO bardoxolone methyl inhibits the reaction [Dietary Fats results in decreased expression of UCP2 protein] CTD PMID:25637688 NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of VEGFA protein]; bardoxolone methyl inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA] CTD PMID:26918785 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
beta-damascenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Calml5 calmodulin-like 5 increases expression ISO beta-damascenone results in increased expression of CALM4 mRNA CTD PMID:22982537 NCBI chr17:66,394,433...66,395,390 JBrowse link
G Casp14 caspase 14 increases expression
affects localization
ISO beta-damascenone results in increased expression of CASP14 mRNA
beta-damascenone affects the localization of CASP14 protein
CTD PMID:22982537 NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405
JBrowse link
G Ces3a carboxylesterase 3a increases expression ISO beta-damascenone results in increased expression of CES3 mRNA CTD PMID:22982537 NCBI chr19:32,992,386...33,000,562 JBrowse link
G Clca1 chloride channel accessory 1 increases expression ISO beta-damascenone results in increased expression of CLCA1 mRNA CTD PMID:22982537 NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369
JBrowse link
G Clca2 chloride channel accessory 2 increases expression ISO beta-damascenone results in increased expression of CLCA2 mRNA CTD PMID:22982537 NCBI chr 2:233,993,619...234,022,691
Ensembl chr 2:233,995,078...234,022,199
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 increases expression ISO beta-damascenone results in increased expression of CYP17A1 mRNA CTD PMID:22982537 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Fcgbp Fc fragment of IgG binding protein increases expression ISO beta-damascenone results in increased expression of FCGBP mRNA CTD PMID:22982537 NCBI chr 1:83,374,979...83,413,083
Ensembl chr 1:83,372,127...83,413,083
JBrowse link
G Flg filaggrin increases expression ISO beta-damascenone results in increased expression of FLG mRNA; beta-damascenone results in increased expression of FLG protein CTD PMID:22982537 NCBI chr 2:178,888,688...178,912,731 JBrowse link
G Hrnr hornerin increases expression ISO beta-damascenone results in increased expression of HRNR mRNA CTD PMID:22982537
G Il20ra interleukin 20 receptor subunit alpha increases expression ISO beta-damascenone results in increased expression of IL20RA mRNA CTD PMID:22982537 NCBI chr 1:14,424,215...14,494,226
Ensembl chr 1:14,451,228...14,493,602
JBrowse link
G Il36rn interleukin 36 receptor antagonist increases expression ISO beta-damascenone results in increased expression of IL36RN mRNA CTD PMID:22982537 NCBI chr 3:7,044,419...7,051,016
Ensembl chr 3:7,044,406...7,051,016
JBrowse link
G Krt1 keratin 1 increases expression ISO beta-damascenone results in increased expression of KRT1 mRNA CTD PMID:22982537 NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
JBrowse link
G Krt10 keratin 10 increases expression ISO beta-damascenone results in increased expression of KRT10 mRNA CTD PMID:22982537 NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701
JBrowse link
G Lce1d late cornified envelope 1D increases expression ISO beta-damascenone results in increased expression of LCE1D mRNA CTD PMID:22982537
G Lce1f late cornified envelope 1F increases expression ISO beta-damascenone results in increased expression of LCE1F mRNA CTD PMID:22982537 NCBI chr 2:178,305,786...178,307,372
Ensembl chr 2:178,305,786...178,307,372
JBrowse link
G Lce1l late cornified envelope 1L increases expression ISO beta-damascenone results in increased expression of LCE1B mRNA CTD PMID:22982537 NCBI chr 2:178,462,100...178,463,433
Ensembl chr 2:178,462,100...178,463,433
JBrowse link
G Lipm lipase, family member M increases expression ISO beta-damascenone results in increased expression of LIPM mRNA CTD PMID:22982537 NCBI chr 1:231,618,145...231,637,599
Ensembl chr 1:231,618,284...231,637,410
JBrowse link
G Loricrin loricrin cornified envelope precursor protein increases expression ISO beta-damascenone results in increased expression of LOR mRNA CTD PMID:22982537 NCBI chr 2:177,558,062...177,559,980
Ensembl chr 2:177,558,252...177,559,807
JBrowse link
G Otop3 otopetrin 3 increases expression ISO beta-damascenone results in increased expression of OTOP3 mRNA CTD PMID:22982537 NCBI chr10:100,577,346...100,588,729
Ensembl chr10:100,577,392...100,588,726
JBrowse link
G Pla2g4f phospholipase A2, group IVF increases expression ISO beta-damascenone results in increased expression of PLA2G4F mRNA CTD PMID:22982537 NCBI chr 3:107,249,053...107,266,201
Ensembl chr 3:107,250,075...107,264,689
JBrowse link
G Plcxd1 phosphatidylinositol-specific phospholipase C, X domain containing 1 increases expression ISO beta-damascenone results in increased expression of PLCXD1 mRNA CTD PMID:22982537 NCBI chr12:46,578,917...46,582,181
Ensembl chr12:46,579,225...46,582,392
JBrowse link
G Sdr16c5 short chain dehydrogenase/reductase family 16C, member 5 increases expression ISO beta-damascenone results in increased expression of SDR16C5 mRNA CTD PMID:22982537 NCBI chr 5:17,018,813...17,043,974
Ensembl chr 5:17,018,813...17,040,970
JBrowse link
G Susd2 sushi domain containing 2 increases expression ISO beta-damascenone results in increased expression of SUSD2 mRNA CTD PMID:22982537 NCBI chr20:13,017,468...13,024,903
Ensembl chr20:13,017,477...13,024,903
JBrowse link
G Tmprss4 transmembrane serine protease 4 increases expression ISO beta-damascenone results in increased expression of TMPRSS4 mRNA CTD PMID:22982537 NCBI chr 8:45,475,819...45,508,409
Ensembl chr 8:45,476,053...45,508,409
JBrowse link
beta-hexachlorocyclohexane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of ABCA1 mRNA CTD PMID:25270620 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 increases expression ISO beta-hexachlorocyclohexane results in increased expression of ABCB11 mRNA CTD PMID:28392238 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO beta-hexachlorocyclohexane results in increased expression of ABCC2 mRNA CTD PMID:28392238 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO beta-hexachlorocyclohexane results in increased expression of ABCC3 mRNA CTD PMID:28392238 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of ABCG1 mRNA CTD PMID:25270620 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression ISO beta-hexachlorocyclohexane results in increased expression of ABCG8 mRNA; beta-hexachlorocyclohexane results in increased expression of ABCG8 protein CTD PMID:27203212 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
JBrowse link
G Acadl acyl-CoA dehydrogenase, long chain decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of ACADL mRNA; beta-hexachlorocyclohexane results in decreased expression of ACADL protein CTD PMID:28397872 NCBI chr 9:68,333,981...68,372,149
Ensembl chr 9:68,333,980...68,372,220
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of ACADM mRNA; beta-hexachlorocyclohexane results in decreased expression of ACADM protein CTD PMID:28397872 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acads acyl-CoA dehydrogenase short chain decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of ACADS mRNA; beta-hexachlorocyclohexane results in decreased expression of ACADS protein CTD PMID:28397872 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of ACOX1 mRNA CTD PMID:28397872 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing affects response to substance
multiple interactions
ISO ADIPOQ gene SNP affects the susceptibility to beta-hexachlorocyclohexane
[ADIPOQ gene SNP affects the susceptibility to beta-hexachlorocyclohexane] which affects the expression of ADIPOQ protein
CTD PMID:27883041 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Agtr1a angiotensin II receptor, type 1a decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of AGTR1A mRNA CTD PMID:25270620 NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
JBrowse link
G Ahr aryl hydrocarbon receptor affects expression
multiple interactions
ISO beta-hexachlorocyclohexane affects the expression of AHR protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide affects the reaction [beta-hexachlorocyclohexane affects the expression of AHR protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [beta-hexachlorocyclohexane affects the expression of AHR protein]
CTD PMID:33207735 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Akap13 A-kinase anchoring protein 13 increases expression ISO beta-hexachlorocyclohexane results in increased expression of AKAP13 mRNA CTD PMID:25270620 NCBI chr 1:129,313,183...129,619,647
Ensembl chr 1:129,314,402...129,619,646
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of ALAS1 mRNA CTD PMID:25270620 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Alg5 ALG5, dolichyl-phosphate beta-glucosyltransferase increases expression ISO beta-hexachlorocyclohexane results in increased expression of ALG5 mRNA CTD PMID:25270620 NCBI chr 2:138,936,998...138,951,228
Ensembl chr 2:138,936,993...138,951,216
JBrowse link
G Ank1 ankyrin 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of ANK1 mRNA CTD PMID:25270620 NCBI chr16:68,876,294...69,054,812
Ensembl chr16:68,877,504...69,054,759
JBrowse link
G Apoa5 apolipoprotein A5 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of APOA5 mRNA CTD PMID:25270620 NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
JBrowse link
G Ar androgen receptor multiple interactions
affects expression
ISO beta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]; bicalutamide affects the reaction [beta-hexachlorocyclohexane affects the expression of AR protein] CTD PMID:26022396 PMID:33207735 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Atp11b ATPase phospholipid transporting 11B (putative) increases expression ISO beta-hexachlorocyclohexane results in increased expression of ATP11B mRNA CTD PMID:25270620 NCBI chr 2:118,585,348...118,691,076
Ensembl chr 2:118,585,342...118,690,232
JBrowse link
G Atp7b ATPase copper transporting beta increases expression ISO beta-hexachlorocyclohexane results in increased expression of ATP7B mRNA CTD PMID:25270620 NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636
JBrowse link
G Bcr BCR activator of RhoGEF and GTPase decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of BCR mRNA CTD PMID:25270620 NCBI chr20:13,471,679...13,596,497
Ensembl chr20:13,471,668...13,597,016
JBrowse link
G Brca1 BRCA1, DNA repair associated multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA]; fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of BRCA1 mRNA] CTD PMID:20206645 NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
JBrowse link
G Casp3 caspase 3 increases cleavage EXP beta-hexachlorocyclohexane results in increased cleavage of CASP3 protein CTD PMID:19760616 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases cleavage EXP beta-hexachlorocyclohexane results in increased cleavage of CASP8 protein CTD PMID:19760616 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Cat catalase multiple interactions EXP [Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of CAT protein CTD PMID:16046044 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccdc63 coiled-coil domain containing 63 increases expression ISO beta-hexachlorocyclohexane results in increased expression of CCDC63 mRNA CTD PMID:25270620 NCBI chr12:34,424,388...34,453,080
Ensembl chr12:34,424,344...34,453,085
JBrowse link
G Ccnd1 cyclin D1 increases expression
multiple interactions
ISO beta-hexachlorocyclohexane results in increased expression of CCND1 mRNA
fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of CCND1 mRNA]
CTD PMID:17640349 PMID:20206645 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cd19 CD19 molecule increases expression ISO beta-hexachlorocyclohexane results in increased expression of CD19 mRNA CTD PMID:25270620 NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO beta-hexachlorocyclohexane results in increased expression of CDKN1B mRNA CTD PMID:17640349 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cers6 ceramide synthase 6 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of CERS6 mRNA CTD PMID:25270620 NCBI chr 3:53,630,636...53,879,692
Ensembl chr 3:53,630,959...53,876,848
JBrowse link
G Ces1d carboxylesterase 1D increases expression ISO beta-hexachlorocyclohexane results in increased expression of CES1D mRNA CTD PMID:25270620 NCBI chr19:13,873,490...13,912,035 JBrowse link
G Cops8 COP9 signalosome subunit 8 increases expression ISO beta-hexachlorocyclohexane results in increased expression of COPS8 mRNA CTD PMID:25270620 NCBI chr 9:91,207,427...91,217,258
Ensembl chr 9:91,207,395...91,217,258
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of CPT1A mRNA CTD PMID:25270620 PMID:28397872 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Ctss cathepsin S increases expression ISO beta-hexachlorocyclohexane results in increased expression of CTSS mRNA CTD PMID:25270620 NCBI chr 2:183,089,192...183,114,483
Ensembl chr 2:183,086,437...183,114,483
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of CYP27A1 mRNA CTD PMID:28392238 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of CYP2B10 mRNA CTD PMID:25270620 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 increases expression ISO beta-hexachlorocyclohexane results in increased expression of CYP2C55 mRNA CTD PMID:25270620 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of CYP2C38 mRNA CTD PMID:25270620 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 increases expression ISO beta-hexachlorocyclohexane results in increased expression of CYP2C29 mRNA CTD PMID:25270620
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of CYP7A1 mRNA CTD PMID:28392238 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of CYP8B1 mRNA CTD PMID:28392238 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Dab1 DAB adaptor protein 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of DAB1 mRNA CTD PMID:25270620 NCBI chr 5:118,392,953...119,513,625
Ensembl chr 5:119,140,533...119,510,552
JBrowse link
G Drd2 dopamine receptor D2 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of DRD2 mRNA CTD PMID:25270620 NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875
JBrowse link
G Dtl denticleless E3 ubiquitin protein ligase homolog decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of DTL mRNA CTD PMID:25270620 NCBI chr13:103,115,810...103,155,029
Ensembl chr13:103,117,186...103,154,890
JBrowse link
G Dync2i1 dynein 2 intermediate chain 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of DYNC2I1 mRNA CTD PMID:25270620 NCBI chr 6:137,133,418...137,189,937
Ensembl chr 6:137,133,418...137,188,719
JBrowse link
G Eif2b3 eukaryotic translation initiation factor 2B subunit gamma increases expression ISO beta-hexachlorocyclohexane results in increased expression of EIF2B3 mRNA CTD PMID:25270620 NCBI chr 5:130,492,167...130,558,692
Ensembl chr 5:130,492,220...130,563,332
JBrowse link
G Emp2 epithelial membrane protein 2 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of EMP2 mRNA CTD PMID:25270620 NCBI chr10:5,360,073...5,394,734
Ensembl chr10:5,360,073...5,394,733
JBrowse link
G Epb41 erythrocyte membrane protein band 4.1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of EPB41 mRNA CTD PMID:25270620 NCBI chr 5:144,110,010...144,264,037
Ensembl chr 5:144,111,906...144,237,821
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 increases expression
multiple interactions
increases activity
ISO beta-hexachlorocyclohexane results in increased expression of ERBB2 mRNA
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; afimoxifene inhibits the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]
beta-hexachlorocyclohexane results in increased activity of ERBB2 protein
beta-hexachlorocyclohexane results in increased expression of ERBB2 protein
CTD PMID:9443065 PMID:11222871 PMID:12439862 PMID:12948864 PMID:17640349 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 multiple interactions ISO 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; afimoxifene inhibits the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein] CTD PMID:12439862 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Ermp1 endoplasmic reticulum metallopeptidase 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of ERMP1 mRNA CTD PMID:25270620 NCBI chr 1:227,383,992...227,422,120
Ensembl chr 1:227,387,920...227,436,909
JBrowse link
G Esr1 estrogen receptor 1 decreases expression
increases expression
multiple interactions
increases activity
ISO beta-hexachlorocyclohexane results in decreased expression of ESR1 mRNA; beta-hexachlorocyclohexane results in decreased expression of ESR1 protein
beta-hexachlorocyclohexane results in increased expression of ESR1 mRNA
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in decreased expression of ESR1 mRNA]; fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in decreased expression of ESR1 mRNA]
beta-hexachlorocyclohexane results in increased expression of ESR1 protein
beta-hexachlorocyclohexane results in increased activity of ESR1 protein
[Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in increased expression of ESR1 mRNA; beta-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR1 protein]
CTD PMID:12948864 PMID:15064155 PMID:15541753 PMID:16758953 PMID:20206645 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
increases activity
ISO beta-hexachlorocyclohexane inhibits the reaction [Estradiol binds to ESR2 protein]
beta-hexachlorocyclohexane results in increased activity of ESR2 protein
CTD PMID:15064155 PMID:21278053 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Etv1 ETS variant transcription factor 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of ETV1 mRNA CTD PMID:25270620 NCBI chr 6:55,590,149...55,681,784
Ensembl chr 6:55,590,234...55,681,775
JBrowse link
G Exosc8 exosome component 8 increases expression ISO beta-hexachlorocyclohexane results in increased expression of EXOSC8 mRNA CTD PMID:25270620 NCBI chr 2:138,930,405...138,937,009
Ensembl chr 2:138,930,405...138,936,928
JBrowse link
G Fabp5 fatty acid binding protein 5 increases expression ISO beta-hexachlorocyclohexane results in increased expression of FABP5 mRNA CTD PMID:28392238 NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773
JBrowse link
G Fam107a family with sequence similarity 107, member A decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of FAM107A mRNA CTD PMID:25270620 NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396
JBrowse link
G Faslg Fas ligand multiple interactions
increases expression
EXP Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of FASLG protein] CTD PMID:19760616 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fasn fatty acid synthase increases expression ISO beta-hexachlorocyclohexane results in increased expression of FASN protein CTD PMID:27203212 PMID:28397872 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fgf19 fibroblast growth factor 19 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of FGF15 mRNA CTD PMID:28392238 NCBI chr 1:200,056,656...200,059,944
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity EXP beta-hexachlorocyclohexane results in increased activity of G6PD protein CTD PMID:2461408 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gnrh1 gonadotropin releasing hormone 1 multiple interactions ISO [Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in increased expression of GNRH1 mRNA CTD PMID:16758953 NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581
JBrowse link
G Gpr146 G protein-coupled receptor 146 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of GPR146 mRNA CTD PMID:25270620 NCBI chr12:15,251,936...15,267,217
Ensembl chr12:15,251,813...15,267,206
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP [Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of GSR protein CTD PMID:16046044 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gstm1 glutathione S-transferase mu 1 affects response to substance ISO GSTM1 gene polymorphism affects the susceptibility to beta-hexachlorocyclohexane CTD PMID:22310945 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
JBrowse link
G H2ax H2A.X variant histone increases phosphorylation ISO beta-hexachlorocyclohexane results in increased phosphorylation of H2AX protein CTD PMID:33207735 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hmox1 heme oxygenase 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of HMOX1 mRNA CTD PMID:25270620 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hyal1 hyaluronidase 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of HYAL1 mRNA CTD PMID:25270620 NCBI chr 8:108,250,654...108,254,526
Ensembl chr 8:108,250,667...108,260,210
JBrowse link
G Igf1r insulin-like growth factor 1 receptor increases expression ISO beta-hexachlorocyclohexane results in increased expression of IGF1R mRNA CTD PMID:17640349 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igsf3 immunoglobulin superfamily, member 3 increases expression ISO beta-hexachlorocyclohexane results in increased expression of IGSF3 mRNA CTD PMID:25270620 NCBI chr 2:188,811,394...188,899,645
Ensembl chr 2:188,811,380...188,899,645
JBrowse link
G Jmjd6 jumonji domain containing 6, arginine demethylase and lysine hydroxylase increases expression ISO beta-hexachlorocyclohexane results in increased expression of JMJD6 mRNA CTD PMID:25270620 NCBI chr10:102,041,131...102,047,182
Ensembl chr10:102,041,120...102,047,182
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions
increases expression
EXP [beta-hexachlorocyclohexane co-treated with Dichlorodiphenyl Dichloroethylene] results in increased expression of JUN mRNA
beta-hexachlorocyclohexane results in increased expression of JUN mRNA
CTD PMID:18481421 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kank3 KN motif and ankyrin repeat domains 3 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of KANK3 mRNA CTD PMID:25270620 NCBI chr 7:14,594,358...14,607,675
Ensembl chr 7:14,594,422...14,607,675
JBrowse link
G Kcnd2 potassium voltage-gated channel subfamily D member 2 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of KCND2 mRNA CTD PMID:25270620 NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728
JBrowse link
G Kdelr2 KDEL endoplasmic reticulum protein retention receptor 2 increases expression ISO beta-hexachlorocyclohexane results in increased expression of KDELR2 mRNA CTD PMID:25270620 NCBI chr12:11,138,820...11,157,117
Ensembl chr12:11,138,820...11,157,153
JBrowse link
G Kif24 kinesin family member 24 increases expression ISO beta-hexachlorocyclohexane results in increased expression of KIF24 mRNA CTD PMID:25270620 NCBI chr 5:56,561,019...56,628,040
Ensembl chr 5:56,561,154...56,628,025
JBrowse link
G Krt19 keratin 19 increases expression ISO beta-hexachlorocyclohexane results in increased expression of KRT19 mRNA CTD PMID:17640349 NCBI chr10:85,075,835...85,080,552 JBrowse link
G Lcn8 lipocalin 8 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of LCN8 mRNA CTD PMID:25270620 NCBI chr 3:8,467,934...8,473,691
Ensembl chr 3:8,467,934...8,470,918
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases expression
multiple interactions
ISO beta-hexachlorocyclohexane results in decreased expression of MAPK1 protein
beta-hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK1 protein
CTD PMID:12948864 PMID:20206645 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases expression
multiple interactions
ISO beta-hexachlorocyclohexane results in decreased expression of MAPK3 protein
beta-hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of MAPK3 protein
CTD PMID:12948864 PMID:20206645 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions
EXP beta-hexachlorocyclohexane results in increased phosphorylation of MAPK8 protein
Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane results in increased phosphorylation of MAPK8 protein]
CTD PMID:19760616 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
EXP Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane results in increased phosphorylation of MAPK9 protein] CTD PMID:19760616 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mgme1 mitochondrial genome maintenance exonuclease 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of MGME1 mRNA CTD PMID:25270620 NCBI chr 3:131,640,770...131,649,933
Ensembl chr 3:131,640,944...131,649,932
JBrowse link
G Mmp12 matrix metallopeptidase 12 increases expression ISO beta-hexachlorocyclohexane results in increased expression of MMP12 mRNA CTD PMID:17640349 NCBI chr 8:4,581,785...4,591,687
Ensembl chr 8:4,581,785...4,599,611
JBrowse link
G Mmp13 matrix metallopeptidase 13 increases expression ISO beta-hexachlorocyclohexane results in increased expression of MMP13 mRNA CTD PMID:17640349 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression ISO beta-hexachlorocyclohexane results in increased expression of MMP9 protein CTD PMID:12948864 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mroh9 maestro heat-like repeat family member 9 increases expression ISO beta-hexachlorocyclohexane results in increased expression of MROH9 mRNA CTD PMID:25270620 NCBI chr13:75,387,800...75,443,118
Ensembl chr13:75,387,746...75,443,092
JBrowse link
G Mylip myosin regulatory light chain interacting protein decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of MYLIP mRNA CTD PMID:25270620 NCBI chr17:19,286,649...19,308,295
Ensembl chr17:19,286,650...19,308,295
JBrowse link
G Myo1e myosin IE decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of MYO1E mRNA CTD PMID:25270620 NCBI chr 8:70,887,934...71,080,180
Ensembl chr 8:70,887,870...71,080,169
JBrowse link
G Nadk NAD kinase increases expression ISO beta-hexachlorocyclohexane results in increased expression of NADK mRNA CTD PMID:25270620 NCBI chr 5:166,145,708...166,176,328
Ensembl chr 5:166,145,481...166,176,322
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 increases expression ISO beta-hexachlorocyclohexane results in increased expression of NR1H4 mRNA CTD PMID:28392238 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO beta-hexachlorocyclohexane binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr2c1 nuclear receptor subfamily 2, group C, member 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of NR2C1 mRNA CTD PMID:25270620 NCBI chr 7:28,715,347...28,768,624
Ensembl chr 7:28,715,562...28,767,160
JBrowse link
G Ntsr2 neurotensin receptor 2 increases expression ISO beta-hexachlorocyclohexane results in increased expression of NTSR2 mRNA CTD PMID:25270620 NCBI chr 6:39,424,297...39,431,015
Ensembl chr 6:39,424,324...39,431,014
JBrowse link
G Pdgfrb platelet derived growth factor receptor beta decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of PDGFRB mRNA CTD PMID:25270620 NCBI chr18:54,500,002...54,538,843
Ensembl chr18:54,499,964...54,538,843
JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of PFKFB1 mRNA CTD PMID:25270620 NCBI chr  X:19,508,522...19,562,165
Ensembl chr  X:19,508,546...19,562,182
JBrowse link
G Pgr progesterone receptor multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA]; beta-hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein]; fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA]; ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PGR mRNA]
beta-hexachlorocyclohexane results in increased expression of PGR; beta-hexachlorocyclohexane results in increased expression of PGR mRNA
CTD PMID:2479123 PMID:16242299 PMID:20206645 PMID:26022396 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Pla2g12a phospholipase A2, group XIIA increases expression ISO beta-hexachlorocyclohexane results in increased expression of PLA2G12A mRNA CTD PMID:25270620 NCBI chr 2:218,436,450...218,452,760
Ensembl chr 2:218,436,513...218,452,740
JBrowse link
G Pla2g15 phospholipase A2, group XV decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of PLA2G15 mRNA CTD PMID:25270620 NCBI chr19:34,050,685...34,068,070
Ensembl chr19:34,050,694...34,068,063
JBrowse link
G Polr1b RNA polymerase I subunit B decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of POLR1B mRNA CTD PMID:25270620 NCBI chr 3:116,333,910...116,358,385
Ensembl chr 3:116,333,889...116,358,379
JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO [Dichlorodiphenyl Dichloroethylene co-treated with beta-hexachlorocyclohexane] results in decreased expression of POMC mRNA CTD PMID:16758953 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Por cytochrome p450 oxidoreductase increases expression ISO beta-hexachlorocyclohexane results in increased expression of POR mRNA CTD PMID:25270620 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Prl prolactin multiple interactions
increases expression
ISO ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of PRL mRNA] CTD PMID:8968093 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Prpf18 pre-mRNA processing factor 18 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of PRPF18 mRNA CTD PMID:25270620 NCBI chr17:73,630,560...73,661,210
Ensembl chr17:73,630,571...73,690,979
JBrowse link
G Psmd12 proteasome 26S subunit, non-ATPase 12 increases expression ISO beta-hexachlorocyclohexane results in increased expression of PSMD12 mRNA CTD PMID:25270620 NCBI chr10:92,438,223...92,457,323
Ensembl chr10:92,438,298...92,457,287
JBrowse link
G Ptges prostaglandin E synthase increases expression ISO beta-hexachlorocyclohexane results in increased expression of PTGES mRNA CTD PMID:25270620 NCBI chr 3:14,177,892...14,189,236 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
affects localization
EXP Acetylcysteine inhibits the reaction [beta-hexachlorocyclohexane affects the localization of RELA protein] CTD PMID:19760616 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rgs3 regulator of G-protein signaling 3 increases expression ISO beta-hexachlorocyclohexane results in increased expression of RGS3 mRNA CTD PMID:25270620 NCBI chr 5:76,022,038...76,161,895
Ensembl chr 5:76,022,001...76,161,894
JBrowse link
G Scd stearoyl-CoA desaturase increases expression ISO beta-hexachlorocyclohexane results in increased expression of SCD1 mRNA; beta-hexachlorocyclohexane results in increased expression of SCD1 protein CTD PMID:27203212 PMID:28397872 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Serpina7 serpin family A member 7 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of SERPINA7 protein CTD PMID:19750101 NCBI chr  X:102,663,242...102,722,319
Ensembl chr  X:102,663,405...102,669,040
JBrowse link
G Sh3d21 SH3 domain containing 21 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of SH3D21 mRNA CTD PMID:25270620 NCBI chr 5:138,429,180...138,444,540
Ensembl chr 5:138,429,180...138,444,407
JBrowse link
G Slc10a1 solute carrier family 10 member 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of SLC10A1 mRNA CTD PMID:28392238 NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
JBrowse link
G Slc10a2 solute carrier family 10 member 2 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of SLC10A2 mRNA CTD PMID:28392238 NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475
JBrowse link
G Slc27a1 solute carrier family 27 member 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of SLC27A1 mRNA CTD PMID:25270620 NCBI chr16:18,278,984...18,300,173
Ensembl chr16:18,278,984...18,296,063
JBrowse link
G Slc29a1 solute carrier family 29 member 1 increases expression ISO beta-hexachlorocyclohexane results in increased expression of SLC29A1 mRNA CTD PMID:25270620 NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
JBrowse link
G Slc2a4 solute carrier family 2 member 4 decreases expression EXP beta-hexachlorocyclohexane results in decreased expression of SLC2A4 protein CTD PMID:31923579 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slc51a solute carrier family 51 subunit alpha decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of SLC51A mRNA CTD PMID:28392238 NCBI chr11:68,299,086...68,313,485
Ensembl chr11:68,299,086...68,313,485
JBrowse link
G Slc51b solute carrier family 51 subunit beta decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of SLC51B mRNA CTD PMID:28392238 NCBI chr 8:65,931,891...65,934,893
Ensembl chr 8:65,931,890...65,940,145
JBrowse link
G Sntb2 syntrophin, beta 2 increases expression ISO beta-hexachlorocyclohexane results in increased expression of SNTB2 mRNA CTD PMID:25270620 NCBI chr19:34,831,657...34,922,325
Ensembl chr19:34,831,584...34,914,113
JBrowse link
G Spag16 sperm associated antigen 16 increases expression ISO beta-hexachlorocyclohexane results in increased expression of SPAG16 mRNA CTD PMID:25270620 NCBI chr 9:71,333,005...72,252,772 JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO beta-hexachlorocyclohexane results in increased phosphorylation of and results in increased activity of SRC protein CTD PMID:20206645 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Srcap Snf2-related CREBBP activator protein increases expression ISO beta-hexachlorocyclohexane results in increased expression of SRCAP mRNA CTD PMID:25270620 NCBI chr 1:182,123,562...182,172,643
Ensembl chr 1:182,118,416...182,176,610
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 decreases expression
increases expression
ISO beta-hexachlorocyclohexane results in decreased expression of SREBF1 mRNA
beta-hexachlorocyclohexane results in increased expression of SREBF1 mRNA; beta-hexachlorocyclohexane results in increased expression of SREBF1 protein
CTD PMID:25270620 PMID:27203212 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
JBrowse link
G Tacc1 transforming, acidic coiled-coil containing protein 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of TACC1 mRNA CTD PMID:25270620 NCBI chr16:66,812,232...66,895,736
Ensembl chr16:66,812,295...66,895,733
JBrowse link
G Tff1 trefoil factor 1 multiple interactions
increases expression
ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [beta-hexachlorocyclohexane results in increased expression of TFF1 mRNA] CTD PMID:8968093 PMID:16242299 PMID:20206645 NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
JBrowse link
G Thumpd2 THUMP domain containing 2 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of THUMPD2 mRNA CTD PMID:25270620 NCBI chr 6:13,924,742...13,976,657
Ensembl chr 6:13,924,765...13,976,657
JBrowse link
G Tns1 tensin 1 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of TNS1 mRNA CTD PMID:25270620 NCBI chr 9:75,491,886...75,702,853
Ensembl chr 9:75,495,814...75,703,225
JBrowse link
G Tpm3 tropomyosin 3 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of TPM3 mRNA CTD PMID:25270620 NCBI chr 2:175,517,198...175,545,014
Ensembl chr 2:175,517,226...175,545,013
JBrowse link
G Trim42 tripartite motif-containing 42 increases expression ISO beta-hexachlorocyclohexane results in increased expression of TRIM42 mRNA CTD PMID:25270620 NCBI chr 8:97,902,349...97,923,268
Ensembl chr 8:97,902,353...97,923,268
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions ISO beta-hexachlorocyclohexane affects the expression of and affects the secretion of TSHB protein CTD PMID:19750101 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Tssc4 tumor suppressing subtransferable candidate 4 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of TSSC4 mRNA CTD PMID:25270620 NCBI chr 1:198,251,986...198,254,810
Ensembl chr 1:198,235,487...198,254,980
JBrowse link
G Ttc39b tetratricopeptide repeat domain 39B increases expression ISO beta-hexachlorocyclohexane results in increased expression of TTC39B mRNA CTD PMID:25270620 NCBI chr 5:97,603,329...97,708,103
Ensembl chr 5:97,609,392...97,736,270
JBrowse link
G Zfp113 zinc finger protein 3 increases expression ISO beta-hexachlorocyclohexane results in increased expression of ZFP113 mRNA CTD PMID:25270620 NCBI chr12:17,022,104...17,033,776 JBrowse link
G Zfp597 zinc finger protein 597 decreases expression ISO beta-hexachlorocyclohexane results in decreased expression of ZFP597 mRNA CTD PMID:25270620 NCBI chr10:11,653,169...11,658,843
Ensembl chr10:11,653,127...11,660,675
JBrowse link
beta-thujaplicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Becn1 beclin 1 increases expression ISO beta-thujaplicin results in increased expression of BECN1 protein CTD PMID:25044443 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Mtor mechanistic target of rapamycin kinase decreases phosphorylation ISO beta-thujaplicin results in decreased phosphorylation of MTOR protein CTD PMID:25044443 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation ISO beta-thujaplicin results in decreased phosphorylation of RPS6KB1 protein CTD PMID:25044443 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Sqstm1 sequestosome 1 decreases expression ISO beta-thujaplicin results in decreased expression of SQSTM1 protein CTD PMID:25044443 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
camphor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Col1a2 collagen type I alpha 2 chain affects expression ISO Camphor analog affects the expression of COL1A2 mRNA CTD PMID:24704097 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP Camphor results in decreased activity of CYP2B1 protein CTD PMID:9242356 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO Camphor inhibits the reaction [CYP2B6 protein results in increased hydrolysis of Bupropion] CTD PMID:18611395 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Camphor binds to and results in increased activity of ESR1 protein CTD PMID:27633901 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
JBrowse link
G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO Camphor promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein]] CTD PMID:15588619 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Camphor inhibits the reaction [cinnamaldehyde results in increased activity of MPO protein] CTD PMID:21466812 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Pgr progesterone receptor multiple interactions ISO Camphor binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
G Runx2 RUNX family transcription factor 2 affects expression ISO Camphor analog affects the expression of RUNX2 mRNA CTD PMID:24704097 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Sparc secreted protein acidic and cysteine rich affects expression ISO Camphor analog affects the expression of SPARC mRNA CTD PMID:24704097 NCBI chr10:39,516,394...39,538,252
Ensembl chr10:39,516,406...39,538,396
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP Lidocaine promotes the reaction [Camphor results in increased activity of TRPV1 protein] CTD PMID:18172555 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Trpv3 transient receptor potential cation channel, subfamily V, member 3 increases activity
multiple interactions
ISO Camphor results in increased activity of TRPV3 protein
isopentenyl pyrophosphate inhibits the reaction [Camphor results in increased activity of TRPV3 protein]
CTD PMID:21353389 NCBI chr10:57,883,546...57,915,865
Ensembl chr10:57,883,546...57,913,296
JBrowse link
carveol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rhob ras homolog family member B increases expression
multiple interactions
ISO carveol results in increased expression of RHOB protein
Mevalonic Acid affects the reaction [carveol results in increased expression of RHOB protein]
CTD PMID:12671036 NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of carveol CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589
JBrowse link
conduritol B epoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gba glucosylceramidase beta multiple interactions
decreases activity
ISO
EXP
[conduritol epoxide binds to and results in decreased activity of GBA protein] which results in increased expression of SNCA protein
conduritol epoxide analog results in decreased activity of GBA protein
[conduritol epoxide binds to and results in decreased activity of GBA protein] which affects the localization of SNCA protein; [conduritol epoxide binds to and results in decreased activity of GBA protein] which results in increased expression of SNCA protein
CTD PMID:9101438 PMID:19576930 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263
JBrowse link
G Snca synuclein alpha multiple interactions ISO [conduritol epoxide binds to and results in decreased activity of GBA protein] which affects the localization of SNCA protein; [conduritol epoxide binds to and results in decreased activity of GBA protein] which results in increased expression of SNCA protein CTD PMID:19576930 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
cyclohexanone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Glud1 glutamate dehydrogenase 1 multiple interactions ISO
EXP
cyclohexanone promotes the reaction [2-dichlorobenzene results in increased activity of GLUD1 protein] CTD PMID:2554539 NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957
JBrowse link
G Pgr progesterone receptor multiple interactions ISO cyclohexanone binds to and results in decreased activity of PGR protein CTD PMID:27633901 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
JBrowse link
cyclohexanones term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC686683 similar to olfactory receptor 73 multiple interactions ISO Cyclohexanones binds to and results in increased activity of OLFR73 protein CTD PMID:21142015 NCBI chr 3:73,516,522...73,517,463 JBrowse link
cyclohexene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lta4h leukotriene A4 hydrolase multiple interactions ISO cyclohexene inhibits the reaction [LTA4H protein results in increased chemical synthesis of Leukotriene B4]; cyclohexene inhibits the reaction [LTA4H protein results in increased hydrolysis of Leukotriene A4] CTD PMID:2827578 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600
JBrowse link
cyclopentanone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1c2 aldo-keto reductase family 1, member C2 multiple interactions
increases reduction
ISO [AKR1C2 protein co-treated with NADP] results in increased reduction of cyclopentanone; NADP promotes the reaction [AKR1C2 protein results in increased reduction of cyclopentanone]; Ursodeoxycholic Acid inhibits the reaction [[AKR1C2 protein co-treated with NADP] results in increased reduction of cyclopentanone] CTD PMID:23261716 NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
JBrowse link
G Akr1c3 aldo-keto reductase family 1, member C3 multiple interactions
increases reduction
ISO [AKR1C3 protein co-treated with NADP] results in increased reduction of cyclopentanone; Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein co-treated with NADP] results in increased reduction of cyclopentanone]; NADP promotes the reaction [AKR1C3 protein results in increased reduction of cyclopentanone] CTD PMID:23261716 NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873
JBrowse link
G RGD1564865 similar to 20-alpha-hydroxysteroid dehydrogenase multiple interactions
increases reduction
ISO NADP promotes the reaction [AKR1C1 protein results in increased reduction of cyclopentanone] CTD PMID:23261716 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488
JBrowse link
delta-hexachlorocyclohexane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ar androgen receptor multiple interactions ISO delta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; delta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein] CTD PMID:10696776 PMID:26022396 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Casp3 caspase 3 increases activity ISO delta-hexachlorocyclohexane results in increased activity of CASP3 protein CTD PMID:19818741 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Cat catalase multiple interactions EXP [Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of CAT protein CTD PMID:16046044 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cdipt CDP-diacylglycerol--inositol 3-phosphatidyltransferase decreases activity
multiple interactions
ISO delta-hexachlorocyclohexane results in decreased activity of CDIPT protein
[delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; delta-hexachlorocyclohexane inhibits the reaction [CDIPT protein results in increased chemical synthesis of Cytidine Diphosphate Diglycerides]
CTD PMID:2579070 NCBI chr 1:181,583,098...181,587,409
Ensembl chr 1:181,583,141...181,587,408
JBrowse link
G Esr1 estrogen receptor 1 increases activity ISO delta-hexachlorocyclohexane results in increased activity of ESR1 protein CTD PMID:15064155 PMID:26022396 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 increases activity ISO delta-hexachlorocyclohexane results in increased activity of ESR2 protein CTD PMID:15064155 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
EXP delta-hexachlorocyclohexane inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester results in increased expression of FOS protein]; delta-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Hexachlorocyclohexane results in increased expression of FOS protein]; delta-hexachlorocyclohexane inhibits the reaction [Pentylenetetrazole results in increased expression of FOS mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Pentylenetetrazole results in increased expression of FOS protein]
delta-hexachlorocyclohexane results in decreased expression of FOS mRNA; delta-hexachlorocyclohexane results in decreased expression of FOS protein
CTD PMID:1380685 PMID:7534335 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Gabra1 gamma-aminobutyric acid type A receptor subunit alpha 1 multiple interactions ISO [delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; [delta-hexachlorocyclohexane co-treated with loreclezole] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]] CTD PMID:9316872 PMID:11156579 NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
JBrowse link
G Gabra4 gamma-aminobutyric acid type A receptor subunit alpha 4 multiple interactions ISO delta-hexachlorocyclohexane results in decreased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRG2 protein alternative form] CTD PMID:11156579 NCBI chr14:36,590,782...36,667,724
Ensembl chr14:36,590,782...36,665,844
JBrowse link
G Gabra6 gamma-aminobutyric acid type A receptor subunit alpha6 multiple interactions ISO delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein] CTD PMID:9316872 NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
JBrowse link
G Gabrb1 gamma-aminobutyric acid type A receptor subunit beta1 multiple interactions ISO delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form] CTD PMID:11156579 NCBI chr14:36,068,725...36,548,946
Ensembl chr14:36,080,393...36,548,948
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G Gabrb2 gamma-aminobutyric acid type A receptor subunit beta 2 multiple interactions ISO delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in decreased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRG2 protein alternative form] CTD PMID:11156579 NCBI chr10:26,936,592...27,156,141
Ensembl chr10:26,936,551...27,151,251
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G Gabrb3 gamma-aminobutyric acid type A receptor subunit beta 3 multiple interactions ISO [delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; [delta-hexachlorocyclohexane co-treated with loreclezole] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; delta-hexachlorocyclohexane results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]] CTD PMID:9316872 NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961
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G Gabrg2 gamma-aminobutyric acid type A receptor subunit gamma 2 multiple interactions ISO [delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; [delta-hexachlorocyclohexane co-treated with loreclezole] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Picrotoxin inhibits the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; delta-hexachlorocyclohexane inhibits the reaction [tert-butylbicyclophosphorothionate binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB1 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in decreased activity of [GABRA1 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in decreased activity of [GABRA4 protein binds to GABRB2 protein binds to GABRG2 protein alternative form]; delta-hexachlorocyclohexane results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]; delta-hexachlorocyclohexane results in increased activity of [GABRA6 protein binds to GABRB3 protein binds to GABRG2 protein]; Hexachlorocyclohexane inhibits the reaction [delta-hexachlorocyclohexane promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]] CTD PMID:9316872 PMID:11156579 NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346
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G Gsr glutathione-disulfide reductase multiple interactions EXP [Hexachlorocyclohexane co-treated with alpha-hexachlorocyclohexane co-treated with beta-hexachlorocyclohexane co-treated with delta-hexachlorocyclohexane] results in increased activity of GSR protein CTD PMID:16046044 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 decreases expression ISO delta-hexachlorocyclohexane results in decreased expression of HSD3B1 mRNA CTD PMID:10993823 NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999
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G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO delta-hexachlorocyclohexane binds to and results in increased activity of NR1I2 protein CTD PMID:21115097 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G Pgr progesterone receptor multiple interactions ISO delta-hexachlorocyclohexane inhibits the reaction [16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione results in increased activity of PGR protein] CTD PMID:26022396 NCBI chr 8:6,073,216...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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G Shbg sex hormone binding globulin multiple interactions ISO
EXP
delta-hexachlorocyclohexane inhibits the reaction [Dihydrotestosterone binds to SHBG protein] CTD PMID:9171990 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
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G Star steroidogenic acute regulatory protein multiple interactions ISO delta-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR mRNA]; delta-hexachlorocyclohexane inhibits the reaction [Bucladesine results in increased expression of STAR protein] CTD PMID:10993823 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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diphenylcyclopropenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adm adrenomedullin increases expression ISO diphenylcyclopropenone results in increased expression of ADM mRNA CTD PMID:25236440 NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654
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G Ankrd37 ankyrin repeat domain 37 increases expression ISO diphenylcyclopropenone results in increased expression of ANKRD37 mRNA CTD PMID:25236440 NCBI chr16:46,269,025...46,271,971
Ensembl chr16:46,268,443...46,271,963
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G Cdk12 cyclin-dependent kinase 12 decreases expression ISO diphenylcyclopropenone results in decreased expression of CDK12 mRNA CTD PMID:25236440 NCBI chr10:83,201,177...83,256,906
Ensembl chr10:83,201,211...83,280,888
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G Dnmt3b DNA methyltransferase 3 beta decreases expression ISO diphenylcyclopropenone results in decreased expression of DNMT3B mRNA CTD PMID:25236440 NCBI chr 3:142,130,592...142,169,124
Ensembl chr 3:142,130,592...142,169,124
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G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO diphenylcyclopropenone results in increased expression of FOS mRNA CTD PMID:25236440 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO diphenylcyclopropenone results in increased expression of FOSL1 mRNA CTD PMID:25236440 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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G Hmox1 heme oxygenase 1 increases expression ISO diphenylcyclopropenone results in increased expression of HMOX1 mRNA CTD PMID:20491607 PMID:25236440 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G Maff MAF bZIP transcription factor F increases expression ISO diphenylcyclopropenone results in increased expression of MAFF mRNA CTD PMID:20491607 NCBI chr 7:110,912,499...110,923,851
Ensembl chr 7:110,912,499...110,923,851
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G Mt1 metallothionein 1 increases expression ISO diphenylcyclopropenone results in increased expression of MT1A mRNA CTD PMID:20491607 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A increases expression ISO diphenylcyclopropenone results in increased expression of MT2A mRNA CTD PMID:20491607 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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G Rbm5 RNA binding motif protein 5 decreases expression ISO diphenylcyclopropenone results in decreased expression of RBM5 mRNA CTD PMID:25236440 NCBI chr 8:108,420,220...108,449,481
Ensembl chr 8:108,420,222...108,449,430
JBrowse link
G Srxn1 sulfiredoxin 1 increases expression ISO diphenylcyclopropenone results in increased expression of SRXN1 mRNA CTD PMID:25236440 NCBI chr 3:140,604,490...140,610,050
Ensembl chr 3:140,599,608...140,628,448
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G Stc2 stanniocalcin 2 decreases expression ISO diphenylcyclopropenone results in decreased expression of STC2 mRNA CTD PMID:25236440 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
JBrowse link
G Txn1 thioredoxin 1 increases expression ISO diphenylcyclopropenone results in increased expression of TXN mRNA CTD PMID:20491607 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
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fenchone term browser