CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: canthin-6-one
Accession: CHEBI:3363
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Definition: An indole alkaloid that is 6H-indolo[3,2,1-de][1,5]naphthyridine substituted by an oxo group at position 6.
Synonyms: related_synonym: 6H-Indolo(3,2,1-de)(1,5)naphthyridin-6-one; Formula=C14H8N2O; InChI=1S/C14H8N2O/c17-13-6-5-11-14-10(7-8-15-11)9-3-1-2-4-12(9)16(13)14/h1-8H; InChIKey=ZERVJPYNQLONEK-UHFFFAOYSA-N; SMILES=O=c1ccc2nccc3c4ccccc4n1c23
xref: CAS:479-43-6; KEGG:C09098; KNApSAcK:C00001701; PMID:19325221; PMID:21134431; PMID:21236329; Patent:US2011059977; Reaxys:181378
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Casp3
caspase 3
increases cleavage
ISO
9-hydroxycanthin-6-one results in increased cleavage of CASP3 protein
CTD
PMID:29225138
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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Casp8
caspase 8
increases cleavage
ISO
9-hydroxycanthin-6-one results in increased cleavage of CASP8 protein
CTD
PMID:29225138
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
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Casp9
caspase 9
increases cleavage
ISO
9-hydroxycanthin-6-one results in increased cleavage of CASP9 protein
CTD
PMID:29225138
Ensembl chr 5:154,109,046...154,126,626
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Ccl2
C-C motif chemokine ligand 2
decreases expression
ISO
9-hydroxycanthin-6-one results in decreased expression of CCL2 mRNA
CTD
PMID:29225138
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
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Ccl5
C-C motif chemokine ligand 5
decreases expression
ISO
9-hydroxycanthin-6-one results in decreased expression of CCL5 mRNA
CTD
PMID:29225138
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all