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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:aluminium(0)
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Accession:CHEBI:33629 term browser browse the term
Definition:An elemental aluminium that has formula Al.
Synonyms:related_synonym: Al(0);   Aln;   Formula=Al;   InChI=1S/Al;   InChIKey=XAGFODPZIPBFFR-UHFFFAOYSA-N;   SMILES=[Al];   aluminum metal
 xref: CAS:7429-90-5
 xref_mesh: MESH:D000535


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aluminium(0) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity EXP Aluminum results in decreased activity of ACE protein CTD PMID:12008977 NCBI chr11:105,858,774...105,880,790
Ensembl chr11:105,858,771...105,880,790 		JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity		 ISO [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium co-treated with Zinc] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased activity of ACHE protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA; Aluminum promotes the reaction [Lead results in decreased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA]; Copper inhibits the reaction [Aluminum results in decreased activity of ACHE protein]; Plant Extracts inhibits the reaction [Aluminum results in decreased activity of ACHE protein] CTD PMID:15266904 PMID:23354609 PMID:24486960 PMID:29170048 PMID:37415728 NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728 		JBrowse link
G Acly ATP citrate lyase multiple interactions ISO Aluminum results in increased expression of and results in increased activity of ACLY protein CTD PMID:17762189 NCBI chr11:100,367,178...100,418,826
Ensembl chr11:100,367,179...100,418,826 		JBrowse link
G Aco1 aconitase 1 decreases activity ISO Aluminum results in decreased activity of ACO1 protein CTD PMID:10806405 NCBI chr 4:40,143,429...40,199,011
Ensembl chr 4:40,143,081...40,198,338 		JBrowse link
G Aco2 aconitase 2, mitochondrial decreases activity
multiple interactions		 EXP
ISO		 Aluminum results in decreased activity of ACO2 protein
Aluminum results in decreased expression of and results in decreased activity of ACO2 protein
Aluminum promotes the reaction [Nitroprusside results in decreased activity of ACO2 protein]		 CTD PMID:12470706 PMID:16906525 PMID:19010380 NCBI chr15:81,756,664...81,799,338
Ensembl chr15:81,756,510...81,799,334 		JBrowse link
G Alb albumin affects binding ISO ALB protein binds to Aluminum CTD PMID:14507469 NCBI chr 5:90,608,729...90,624,461
Ensembl chr 5:90,608,756...90,624,461 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
increases expression		 ISO caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 protein]
Aluminum results in increased expression of ALOX5 mRNA; Aluminum results in increased expression of ALOX5 protein		 CTD PMID:27368151 NCBI chr 6:116,387,030...116,438,139
Ensembl chr 6:116,387,038...116,438,139 		JBrowse link
G Alpl alkaline phosphatase, liver/bone/kidney multiple interactions EXP [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of ALPL mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of ALPL mRNA] CTD PMID:34547296 NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695 		JBrowse link
G Apob apolipoprotein B increases expression ISO Aluminum results in increased expression of APOB protein CTD PMID:17762189 NCBI chr12:8,027,629...8,066,839
Ensembl chr12:8,027,648...8,066,835 		JBrowse link
G App amyloid beta precursor protein affects binding
increases cleavage
increases expression
multiple interactions		 ISO
EXP		 APP protein binds to Aluminum
Aluminum results in increased cleavage of APP protein
Aluminum results in increased expression of APP protein
APP protein promotes the reaction [Aluminum results in decreased activity of CHAT protein]; meloxicam inhibits the reaction [Aluminum results in increased expression of APP protein]; Vitamin E inhibits the reaction [Aluminum results in increased cleavage of APP protein]
Aluminum results in increased expression of APP mRNA
[APP protein modified form binds to Aluminum] which results in increased expression of RCVRN mRNA
[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA]		 CTD PMID:12039845 PMID:16308480 PMID:16724269 PMID:16928369 PMID:16942756 More... NCBI chr16:84,751,236...84,972,187
Ensembl chr16:84,746,573...84,970,654 		JBrowse link
G Atxn3 ataxin 3 affects folding
multiple interactions		 EXP
ISO		 Aluminum affects the folding of ATXN3 protein polymorphism
Aluminum promotes the reaction [ATXN3 protein polymorphism binds to ATXN3 protein polymorphism]		 CTD PMID:17300980 NCBI chr12:101,885,160...101,928,139
Ensembl chr12:101,885,160...101,924,505 		JBrowse link
G Bax BCL2-associated X protein affects response to substance
multiple interactions		 ISO
EXP		 BAX protein affects the susceptibility to Aluminum
[aluminum chlorhydrate results in increased abundance of Aluminum] which affects the expression of BAX protein
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX protein]		 CTD PMID:20385067 PMID:31945389 PMID:34547296 NCBI chr 7:45,111,124...45,116,332
Ensembl chr 7:45,111,121...45,116,322 		JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 multiple interactions
decreases expression		 ISO Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]; Ketoglutaric Acids inhibits the reaction [Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]]
Aluminum results in decreased expression of BBOX1 protein		 CTD PMID:21439360 NCBI chr 2:110,094,401...110,145,158
Ensembl chr 2:110,093,042...110,144,905 		JBrowse link
G Bcl2 B cell leukemia/lymphoma 2 multiple interactions ISO
EXP		 [aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein; Fulvestrant inhibits the reaction [[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein]
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein]		 CTD PMID:31945389 PMID:34547296 NCBI chr 1:106,465,906...106,642,020
Ensembl chr 1:106,465,908...106,642,004 		JBrowse link
G Bcl2l1 BCL2-like 1 multiple interactions ISO [aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of BCL2L1 protein CTD PMID:31945389 NCBI chr 2:152,600,652...152,673,632
Ensembl chr 2:152,622,588...152,673,648 		JBrowse link
G Bglap bone gamma carboxyglutamate protein multiple interactions
decreases secretion		 ISO
EXP		 Aluminum inhibits the reaction [Calcitriol results in increased secretion of BGLAP protein]; Calcitriol inhibits the reaction [Aluminum results in decreased secretion of BGLAP protein]
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP protein]		 CTD PMID:9626627 PMID:34547296 NCBI chr 3:88,290,802...88,291,773
Ensembl chr 3:88,290,808...88,291,771 		JBrowse link
G Bgn biglycan increases expression EXP Aluminum results in increased expression of BGN mRNA CTD PMID:37544489 NCBI chr  X:72,527,207...72,539,542
Ensembl chr  X:72,527,208...72,539,539 		JBrowse link
G Cald1 caldesmon 1 increases expression EXP Aluminum results in increased expression of CALD1 mRNA CTD PMID:37544489 NCBI chr 6:34,575,433...34,752,404
Ensembl chr 6:34,575,435...34,752,408 		JBrowse link
G Casp12 caspase 12 multiple interactions EXP [aluminum chloride results in increased abundance of Aluminum] which results in increased expression of CASP12 mRNA CTD PMID:29635646 NCBI chr 9:5,345,419...5,373,034
Ensembl chr 9:5,345,430...5,373,032 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions		 EXP
ISO		 Aluminum results in increased expression of CASP3
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased cleavage of CASP3 protein; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CASP3 mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CASP3 mRNA]
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of CASP3 protein		 CTD PMID:21972528 PMID:34547296 PMID:37415728 NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of CASP9 protein; Fulvestrant inhibits the reaction [[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of CASP9 protein] CTD PMID:31945389 NCBI chr 4:141,520,923...141,543,289
Ensembl chr 4:141,520,923...141,543,287 		JBrowse link
G Casr calcium-sensing receptor multiple interactions ISO [Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium; [Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates; Aluminum binds to and results in increased activity of CASR protein CTD PMID:10231437 NCBI chr16:36,310,947...36,382,605
Ensembl chr16:36,314,058...36,382,503 		JBrowse link
G Cat catalase decreases activity
multiple interactions		 ISO
EXP		 Aluminum results in decreased activity of CAT protein
Vitamin E inhibits the reaction [Aluminum results in decreased activity of CAT protein]
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased activity of CAT protein; CAT protein results in decreased susceptibility to [Tyramine co-treated with Aluminum]; Plant Extracts inhibits the reaction [Aluminum results in decreased activity of CAT protein]
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased activity of CAT protein]		 CTD PMID:15526171 PMID:17709913 PMID:24486960 PMID:34547296 PMID:37415728 NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 decreases expression EXP Aluminum results in decreased expression of CCL7 mRNA CTD PMID:37544489 NCBI chr11:81,936,538...81,938,351
Ensembl chr11:81,936,538...81,938,351 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of CDH1 protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of CDH1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of CDH1 protein CTD PMID:32437896 NCBI chr 8:107,329,982...107,396,879
Ensembl chr 8:107,329,983...107,396,878 		JBrowse link
G Chat choline acetyltransferase decreases expression
multiple interactions
decreases activity		 EXP Aluminum results in decreased expression of CHAT protein
APP protein promotes the reaction [Aluminum results in decreased activity of CHAT protein]; meloxicam inhibits the reaction [Aluminum results in decreased expression of CHAT protein]		 CTD PMID:16724269 PMID:16928369 NCBI chr14:32,130,160...32,187,866
Ensembl chr14:32,130,160...32,187,946 		JBrowse link
G Col1a1 collagen, type I, alpha 1 multiple interactions
decreases expression		 EXP [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of COL1A1 mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of COL1A1 mRNA]
Aluminum results in decreased expression of COL1A1 mRNA		 CTD PMID:34547296 PMID:37544489 NCBI chr11:94,827,050...94,843,868
Ensembl chr11:94,827,050...94,843,868 		JBrowse link
G Crp C-reactive protein, pentraxin-related multiple interactions ISO [Zinc co-treated with Aluminum] results in increased expression of CRP protein; [Zinc co-treated with Copper co-treated with Aluminum] results in increased expression of CRP protein CTD PMID:27816692 NCBI chr 1:172,525,623...172,527,533
Ensembl chr 1:172,525,622...172,660,598 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression EXP Aluminum results in increased expression of CX3CL1 mRNA CTD PMID:37544489 NCBI chr 8:95,498,808...95,509,055
Ensembl chr 8:95,498,637...95,509,055 		JBrowse link
G Cxcl15 C-X-C motif chemokine ligand 15 increases expression ISO Aluminum analog results in increased expression of CXCL8 mRNA CTD PMID:23724284 NCBI chr 5:90,942,393...90,950,926
Ensembl chr 5:90,942,393...90,950,926 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions EXP [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CYCS mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CYCS mRNA] CTD PMID:34547296 NCBI chr 6:50,539,543...50,543,549
Ensembl chr 6:50,539,543...50,543,518 		JBrowse link
G Daxx Fas death domain-associated protein increases expression ISO Aluminum results in increased expression of DAXX mRNA CTD PMID:16308480 NCBI chr17:34,128,379...34,134,564
Ensembl chr17:34,128,388...34,134,564 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions ISO Aluminum inhibits the reaction [SCH 23390 binds to DRD1 protein] CTD PMID:9109525 NCBI chr13:54,205,202...54,209,677
Ensembl chr13:54,205,202...54,209,724 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions ISO Aluminum inhibits the reaction [3-N-methylspiperone binds to DRD2 protein] CTD PMID:9109525 NCBI chr 9:49,251,703...49,319,468
Ensembl chr 9:49,251,927...49,319,477 		JBrowse link
G Ecm1 extracellular matrix protein 1 increases expression EXP Aluminum results in increased expression of ECM1 mRNA CTD PMID:37544489 NCBI chr 3:95,641,459...95,646,880
Ensembl chr 3:95,641,459...95,646,881 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression EXP Aluminum results in increased expression of EGLN3 mRNA; Aluminum results in increased expression of EGLN3 protein CTD PMID:37544489 NCBI chr12:54,225,767...54,250,660
Ensembl chr12:54,225,767...54,250,646 		JBrowse link
G Eno2 enolase 2, gamma neuronal decreases activity ISO Aluminum results in decreased activity of ENO2 protein CTD PMID:11860913 NCBI chr 6:124,737,018...124,746,489
Ensembl chr 6:124,737,016...124,746,636 		JBrowse link
G Epor erythropoietin receptor affects expression ISO Aluminum affects the expression of EPOR protein CTD PMID:15777837 NCBI chr 9:21,870,193...21,874,915
Ensembl chr 9:21,870,193...21,874,802 		JBrowse link
G Esr1 estrogen receptor 1 (alpha) multiple interactions ISO [aluminum chlorhydrate results in increased abundance of Aluminum] inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; [aluminum chlorhydrate results in increased abundance of Aluminum] inhibits the reaction [NRG1 protein results in increased phosphorylation of ESR1 protein]; [aluminum chlorhydrate results in increased abundance of Aluminum] which results in increased expression of ESR1 protein; [Estradiol co-treated with [aluminum chlorhydrate results in increased abundance of Aluminum]] results in increased expression of ESR1 protein CTD PMID:31945389 NCBI chr10:4,561,989...4,955,633
Ensembl chr10:4,561,593...4,955,614 		JBrowse link
G Esr2 estrogen receptor 2 (beta) multiple interactions ISO [[aluminum chlorhydrate results in increased abundance of Aluminum] co-treated with [Tretinoin co-treated with Estradiol]] affects the localization of ESR2 protein; [[aluminum chlorhydrate results in increased abundance of Aluminum] which co-treated with Tretinoin] results in decreased expression of and affects the localization of ESR2 protein; [aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of and affects the localization of ESR2 protein; [Estradiol co-treated with [aluminum chlorhydrate results in increased abundance of Aluminum]] results in decreased expression of ESR2 protein CTD PMID:31945389 NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033 		JBrowse link
G F8 coagulation factor VIII affects folding
multiple interactions		 ISO Aluminum affects the folding of F8 protein
[Aluminum promotes the reaction [F8 protein binds to F8 protein]] which results in decreased activity of F8 protein		 CTD PMID:15349964 NCBI chr  X:74,213,950...74,426,342
Ensembl chr  X:74,216,321...74,426,221 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression EXP Aluminum results in increased expression of FDFT1 mRNA CTD PMID:37544489 NCBI chr14:63,382,599...63,419,136
Ensembl chr14:63,382,599...63,417,027 		JBrowse link
G Fh1 fumarate hydratase 1 multiple interactions ISO Aluminum results in decreased expression of and results in decreased activity of FH protein CTD PMID:16906525 NCBI chr 1:175,428,944...175,453,201
Ensembl chr 1:175,427,940...175,453,201 		JBrowse link
G Fos FBJ osteosarcoma oncogene multiple interactions EXP [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of FOS protein] CTD PMID:23690655 NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047 		JBrowse link
G Fosl1 fos-like antigen 1 increases expression EXP Aluminum results in increased expression of FOSL1 mRNA CTD PMID:37544489 NCBI chr19:5,497,726...5,505,966
Ensembl chr19:5,497,575...5,505,974 		JBrowse link
G G6pdx glucose-6-phosphate dehydrogenase X-linked increases activity ISO Aluminum results in increased activity of G6PD protein CTD PMID:16572710 PMID:16979867 NCBI chr  X:73,453,089...73,472,486
Ensembl chr  X:73,453,089...73,472,800 		JBrowse link
G Gbp3 guanylate binding protein 3 decreases expression EXP Aluminum results in decreased expression of GBP3 mRNA CTD PMID:37544489 NCBI chr 3:142,265,781...142,278,974
Ensembl chr 3:142,265,787...142,278,970 		JBrowse link
G Gchfr GTP cyclohydrolase I feedback regulator increases expression EXP Aluminum results in increased expression of GCHFR mRNA CTD PMID:37544489 NCBI chr 2:118,998,269...119,002,870
Ensembl chr 2:118,998,254...119,002,871 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression
multiple interactions		 ISO
EXP		 Aluminum results in increased expression of GFAP protein
Vitamin E inhibits the reaction [Aluminum results in increased expression of GFAP protein]
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of GFAP protein		 CTD PMID:16545059 PMID:31363819 NCBI chr11:102,778,162...102,791,368
Ensembl chr11:102,778,162...102,791,738 		JBrowse link
G Gnai1 G protein subunit alpha i1 decreases expression ISO Aluminum results in decreased expression of GNAI1 protein CTD PMID:9626627 NCBI chr 5:18,470,133...18,565,411
Ensembl chr 5:18,470,133...18,565,353 		JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression ISO Aluminum results in decreased expression of GNAI2 protein CTD PMID:9626627 NCBI chr 9:107,491,324...107,512,542
Ensembl chr 9:107,491,324...107,512,566 		JBrowse link
G Gnaq guanine nucleotide binding protein, alpha q polypeptide increases response to substance EXP GNAQ protein results in increased susceptibility to Aluminum CTD PMID:15068510 NCBI chr19:16,110,048...16,365,884
Ensembl chr19:16,110,195...16,364,827 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 (soluble) multiple interactions ISO Aluminum results in increased expression of and results in increased activity of GPD1 protein CTD PMID:17762189 NCBI chr15:99,615,468...99,622,895
Ensembl chr15:99,615,396...99,622,886 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity
multiple interactions		 ISO Aluminum results in decreased activity of GPX1 protein
Vitamin E inhibits the reaction [Aluminum results in decreased activity of GPX1 protein]		 CTD PMID:17709913 NCBI chr 9:108,216,279...108,217,541
Ensembl chr 9:108,216,102...108,217,542 		JBrowse link
G Gsr glutathione reductase decreases expression
multiple interactions		 ISO Aluminum results in decreased expression of GSR protein
Plant Extracts inhibits the reaction [Aluminum results in decreased expression of GSR protein]		 CTD PMID:24486960 NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191 		JBrowse link
G H2-T22 histocompatibility 2, T region locus 22 decreases expression EXP Aluminum results in decreased expression of H2-T22 mRNA CTD PMID:37544489 NCBI chr17:36,348,023...36,353,635
Ensembl chr17:36,348,020...36,353,639 		JBrowse link
G Hif1a hypoxia inducible factor 1, alpha subunit increases localization ISO Aluminum results in increased localization of HIF1A protein CTD PMID:16979867 NCBI chr12:73,948,186...73,994,304
Ensembl chr12:73,948,149...73,994,304 		JBrowse link
G Hk1 hexokinase 1 multiple interactions
decreases activity		 ISO Meclofenoxate inhibits the reaction [Aluminum results in decreased activity of HK1 protein] CTD PMID:16969689 NCBI chr10:62,104,634...62,215,699
Ensembl chr10:62,104,634...62,215,687 		JBrowse link
G Hmga1 high mobility group AT-hook 1 increases expression EXP Aluminum results in increased expression of HMGA1 mRNA CTD PMID:37544489 NCBI chr17:27,774,798...27,782,649
Ensembl chr17:27,775,471...27,782,648 		JBrowse link
G Hmga1b high mobility group AT-hook 1B increases expression EXP Aluminum results in increased expression of HMGA1B mRNA CTD PMID:37544489 NCBI chr11:120,653,620...120,655,218
Ensembl chr11:120,653,620...120,655,245 		JBrowse link
G Idh1 isocitrate dehydrogenase 1 (NADP+), soluble decreases activity ISO Aluminum results in decreased activity of IDH1 protein CTD PMID:15486972 NCBI chr 1:65,197,775...65,225,638
Ensembl chr 1:65,197,775...65,225,659 		JBrowse link
G Idh2 isocitrate dehydrogenase 2 (NADP+), mitochondrial decreases activity ISO Aluminum results in decreased activity of IDH2 protein CTD PMID:15486972 NCBI chr 7:79,744,594...79,768,356
Ensembl chr 7:79,744,594...79,765,140 		JBrowse link
G Ifi27l2a interferon, alpha-inducible protein 27 like 2A decreases expression EXP Aluminum results in decreased expression of IFI27L2A mRNA CTD PMID:37544489 NCBI chr12:103,400,132...103,409,939
Ensembl chr12:103,408,426...103,409,939 		JBrowse link
G Ifi35 interferon-induced protein 35 decreases expression EXP Aluminum results in decreased expression of IFI35 mRNA CTD PMID:37544489 NCBI chr11:101,339,238...101,349,527
Ensembl chr11:101,339,233...101,349,524 		JBrowse link
G Ifit1bl1 interferon induced protein with tetratricpeptide repeats 1B like 1 decreases expression EXP Aluminum results in decreased expression of IFIT1 mRNA CTD PMID:37544489 NCBI chr19:34,570,288...34,640,382
Ensembl chr19:34,570,291...34,579,356 		JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression EXP Aluminum results in decreased expression of IFIT3 mRNA CTD PMID:37544489 NCBI chr19:34,560,519...34,566,382
Ensembl chr19:34,560,931...34,566,131 		JBrowse link
G Ifit3b interferon-induced protein with tetratricopeptide repeats 3B decreases expression EXP Aluminum results in decreased expression of IFIT3B mRNA CTD PMID:37544489 NCBI chr19:34,584,945...34,590,801
Ensembl chr19:34,585,370...34,590,801 		JBrowse link
G Ifnb1 interferon beta 1, fibroblast multiple interactions EXP [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IFNB1 mRNA] CTD PMID:23690655 NCBI chr 4:88,440,253...88,441,083
Ensembl chr 4:88,440,262...88,441,011 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Aluminum inhibits the reaction [IGF1 protein results in increased activity of MTR protein] CTD PMID:14745455 NCBI chr10:87,694,127...87,772,909
Ensembl chr10:87,694,127...87,772,904 		JBrowse link
G Igtp interferon gamma induced GTPase decreases expression EXP Aluminum results in decreased expression of IGTP mRNA CTD PMID:37544489 NCBI chr11:58,090,382...58,098,418
Ensembl chr11:58,090,382...58,098,417 		JBrowse link
G Il12b interleukin 12b multiple interactions EXP [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12B mRNA] CTD PMID:23690655 NCBI chr11:44,290,890...44,305,504
Ensembl chr11:44,290,890...44,304,860 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression		 ISO [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of IL1B protein]; Vitamin E inhibits the reaction [Aluminum results in increased expression of IL1B protein] CTD PMID:16545059 PMID:27368151 PMID:29170048 NCBI chr 2:129,206,490...129,213,059
Ensembl chr 2:129,206,490...129,213,059 		JBrowse link
G Il4 interleukin 4 increases expression EXP Aluminum results in increased expression of IL4 mRNA CTD PMID:16630673 NCBI chr11:53,503,287...53,509,492
Ensembl chr11:53,493,809...53,509,496 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression		 ISO [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of IL6 protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of IL6 protein]
[Zinc co-treated with Aluminum] results in increased expression of IL6 protein; [Zinc co-treated with Copper co-treated with Aluminum] results in increased expression of IL6 protein		 CTD PMID:27368151 PMID:27816692 PMID:29170048 PMID:37415728 NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979 		JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression EXP Aluminum results in decreased expression of IRF7 mRNA CTD PMID:37544489 NCBI chr 7:140,843,096...140,846,412
Ensembl chr 7:140,842,619...140,846,394 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression EXP Aluminum results in decreased expression of ISG15 mRNA CTD PMID:37544489 NCBI chr 4:156,283,881...156,285,275
Ensembl chr 4:156,283,912...156,285,253 		JBrowse link
G Jun jun proto-oncogene multiple interactions EXP [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of JUN protein] CTD PMID:23690655 NCBI chr 4:94,937,273...94,940,459
Ensembl chr 4:94,937,271...94,940,459 		JBrowse link
G Klk1 kallikrein 1 multiple interactions ISO Aluminum binds to and results in decreased activity of KLK1 protein CTD PMID:15558947 NCBI chr 7:43,874,784...43,879,046
Ensembl chr 7:43,874,784...43,879,042 		JBrowse link
G Litaf LPS-induced TN factor multiple interactions ISO [Titanium co-treated with Vanadium co-treated with Aluminum] results in increased expression of LITAF mRNA CTD PMID:17408380 NCBI chr16:10,777,137...10,810,985
Ensembl chr16:10,777,139...10,884,021 		JBrowse link
G Lonrf2 LON peptidase N-terminal domain and ring finger 2 decreases expression ISO Aluminum results in decreased expression of LONRF2 mRNA CTD PMID:19010380 NCBI chr 1:38,832,750...38,875,768
Ensembl chr 1:38,832,726...38,875,792 		JBrowse link
G Manf mesencephalic astrocyte-derived neurotrophic factor decreases expression EXP Aluminum results in decreased expression of MANF mRNA; Aluminum results in decreased expression of MANF protein CTD PMID:37544489 NCBI chr 9:106,765,952...106,769,137
Ensembl chr 9:106,715,511...106,769,178 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions EXP [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MAP1LC3B mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased lipidation of MAP1LC3B protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MAP1LC3B mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased lipidation of MAP1LC3B protein] CTD PMID:34547296 NCBI chr 8:122,317,177...122,325,499
Ensembl chr 8:122,317,100...122,325,499 		JBrowse link
G Mapk3 mitogen-activated protein kinase 3 multiple interactions ISO [Aluminum co-treated with Iron] results in increased phosphorylation of MAPK3 protein CTD PMID:16728372 NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991 		JBrowse link
G Mapt microtubule-associated protein tau increases phosphorylation
multiple interactions		 ISO Aluminum results in increased phosphorylation of MAPT protein
[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA]		 CTD PMID:17662457 PMID:29170048 NCBI chr11:104,120,235...104,222,916
Ensembl chr11:104,122,216...104,222,916 		JBrowse link
G Mir21a microRNA 21a multiple interactions ISO [Air Pollutants, Occupational results in increased abundance of Aluminum] which results in increased expression of MIR21 mRNA CTD PMID:27506416 NCBI chr11:86,474,893...86,474,984
Ensembl chr11:86,474,893...86,474,984 		JBrowse link
G Mir30d microRNA 30d multiple interactions ISO [Air Pollutants, Occupational results in increased abundance of Aluminum] which results in increased expression of MIR30D mRNA CTD PMID:27506416 NCBI chr15:68,213,057...68,213,138
Ensembl chr15:68,213,057...68,213,138 		JBrowse link
G Mir322 microRNA 322 multiple interactions ISO [Air Pollutants, Occupational results in increased abundance of Aluminum] which results in increased expression of MIR424 mRNA CTD PMID:27506416 NCBI chr  X:52,143,132...52,143,226
Ensembl chr  X:52,143,132...52,143,226 		JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression ISO Aluminum results in increased expression of MMP2 protein CTD PMID:16052892 NCBI chr 8:93,553,920...93,580,049
Ensembl chr 8:93,553,919...93,580,048 		JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MMP7 mRNA CTD PMID:32437896 NCBI chr 9:7,692,095...7,699,587
Ensembl chr 9:7,692,091...7,699,586 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions		 ISO Aluminum results in increased expression of MMP9 protein
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MMP9 mRNA		 CTD PMID:16052892 PMID:32437896 NCBI chr 2:164,782,246...164,797,770
Ensembl chr 2:164,782,700...164,797,770 		JBrowse link
G Mpo myeloperoxidase increases expression ISO Aluminum results in increased expression of MPO protein CTD PMID:17402216 NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239 		JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 decreases expression EXP Aluminum results in decreased expression of MRPL20 mRNA CTD PMID:37544489 NCBI chr 4:155,887,335...155,893,288
Ensembl chr 4:155,887,335...155,894,432 		JBrowse link
G Msmo1 methylsterol monoxygenase 1 increases expression EXP Aluminum results in increased expression of MSMO1 mRNA CTD PMID:37544489 NCBI chr 8:65,171,157...65,186,822
Ensembl chr 8:65,171,173...65,186,826 		JBrowse link
G mt-Rnr2 16S rRNA, mitochondrial increases expression EXP Aluminum results in increased expression of MT-RNR2 mRNA CTD PMID:37544489 NCBI chr MT:1,094...2,675
Ensembl chr MT:1,094...2,675 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Aluminum inhibits the reaction [IGF1 protein results in increased activity of MTR protein]; Aluminum inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form] CTD PMID:14745455 PMID:26989453 NCBI chr13:12,196,217...12,273,090
Ensembl chr13:12,197,598...12,272,999 		JBrowse link
G Myc myelocytomatosis oncogene increases expression EXP Aluminum results in increased expression of MYC mRNA; Aluminum results in increased expression of MYC protein CTD PMID:37544489 NCBI chr15:61,857,190...61,862,210
Ensembl chr15:61,857,240...61,862,223 		JBrowse link
G Nfe2l2 nuclear factor, erythroid derived 2, like 2 multiple interactions ISO [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFE2L2 protein CTD PMID:37415728 NCBI chr 2:75,505,860...75,535,007
Ensembl chr 2:75,505,857...75,534,985 		JBrowse link
G Nfkb1 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 multiple interactions ISO [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFKB1 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFKB1 protein CTD PMID:37415728 NCBI chr 3:135,290,416...135,397,422
Ensembl chr 3:135,290,416...135,397,308 		JBrowse link
G Nos2 nitric oxide synthase 2, inducible multiple interactions ISO
EXP		 [Aluminum co-treated with Iron] results in increased expression of NOS2 protein
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]		 CTD PMID:16728372 PMID:23690655 NCBI chr11:78,811,613...78,851,052
Ensembl chr11:78,811,613...78,851,080 		JBrowse link
G Nrg1 neuregulin 1 multiple interactions ISO [aluminum chlorhydrate results in increased abundance of Aluminum] inhibits the reaction [NRG1 protein results in increased phosphorylation of ESR1 protein] CTD PMID:31945389 NCBI chr 8:32,299,493...33,381,858
Ensembl chr 8:32,304,579...33,374,825
Ensembl chr 8:32,304,579...33,374,825 		JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression EXP Aluminum results in decreased expression of OAS1A mRNA CTD PMID:37544489 NCBI chr 5:121,034,319...121,045,588
Ensembl chr 5:121,034,319...121,045,584 		JBrowse link
G Oas1g 2'-5' oligoadenylate synthetase 1G decreases expression EXP Aluminum results in decreased expression of OAS1G mRNA CTD PMID:37544489 NCBI chr 5:121,014,205...121,025,676
Ensembl chr 5:121,014,205...121,025,676 		JBrowse link
G Oasl2 2'-5' oligoadenylate synthetase-like 2 decreases expression EXP Aluminum results in decreased expression of OASL2 mRNA CTD PMID:37544489 NCBI chr 5:115,034,995...115,050,306
Ensembl chr 5:115,034,997...115,050,295 		JBrowse link
G Ogdh oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) multiple interactions
increases activity		 ISO Aluminum results in decreased expression of and results in decreased activity of OGDH protein
Aluminum results in increased activity of OGDH protein		 CTD PMID:10806405 PMID:16906525 NCBI chr11:6,241,597...6,309,094
Ensembl chr11:6,241,633...6,306,642 		JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions ISO [Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in decreased abundance of Aluminum CTD PMID:7477890 NCBI chr 4:131,834,980...131,872,042
Ensembl chr 4:131,838,037...131,871,797 		JBrowse link
G Parp10 poly (ADP-ribose) polymerase family, member 10 decreases expression EXP Aluminum results in decreased expression of PARP10 mRNA CTD PMID:37544489 NCBI chr15:76,117,195...76,127,640
Ensembl chr15:76,115,374...76,127,641 		JBrowse link
G Parp9 poly (ADP-ribose) polymerase family, member 9 decreases expression EXP Aluminum results in decreased expression of PARP9 mRNA; Aluminum results in decreased expression of PARP9 protein CTD PMID:37544489 NCBI chr16:35,759,360...35,792,975
Ensembl chr16:35,758,840...35,792,975 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1, cytosolic multiple interactions ISO [aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of PCK1 protein CTD PMID:31945389 NCBI chr 2:172,994,866...173,001,067
Ensembl chr 2:172,994,841...173,001,066 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP [aluminum chloride results in increased abundance of Aluminum] which results in decreased expression of PCNA mRNA CTD PMID:29635646 NCBI chr 2:132,091,206...132,095,100
Ensembl chr 2:132,091,082...132,095,234 		JBrowse link
G Pcyt2 phosphate cytidylyltransferase 2, ethanolamine increases expression EXP Aluminum results in increased expression of PCYT2 mRNA CTD PMID:37544489 NCBI chr11:120,500,888...120,508,784
Ensembl chr11:120,500,913...120,508,762 		JBrowse link
G Pink1 PTEN induced putative kinase 1 multiple interactions EXP [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 protein; Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 mRNA] CTD PMID:34547296 NCBI chr 4:138,040,718...138,053,631
Ensembl chr 4:138,040,720...138,053,618 		JBrowse link
G Pklr pyruvate kinase liver and red blood cell increases activity ISO Aluminum results in increased activity of PKLR protein CTD PMID:16979867 NCBI chr 3:89,043,429...89,054,122
Ensembl chr 3:89,043,449...89,054,091 		JBrowse link
G Plcd1 phospholipase C, delta 1 increases expression ISO Aluminum results in increased expression of PLCD1 protein CTD PMID:10814511 NCBI chr 9:118,900,595...118,922,570
Ensembl chr 9:118,900,595...118,922,570 		JBrowse link
G Prkg2 protein kinase, cGMP-dependent, type II increases expression EXP Aluminum results in increased expression of PRKG2 mRNA CTD PMID:37544489 NCBI chr 5:99,077,632...99,185,042
Ensembl chr 5:99,077,632...99,185,210 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions EXP [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN protein; Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN mRNA] CTD PMID:34547296 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248 		JBrowse link
G Psmb8 proteasome (prosome, macropain) subunit, beta type 8 (large multifunctional peptidase 7) decreases expression EXP Aluminum results in decreased expression of PSMB8 mRNA; Aluminum results in decreased expression of PSMB8 protein CTD PMID:37544489 NCBI chr17:34,417,169...34,420,428
Ensembl chr17:34,416,695...34,420,428 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression EXP Aluminum results in increased expression of PTGS1 mRNA; Aluminum results in increased expression of PTGS1 protein CTD PMID:37544489 NCBI chr 2:36,106,758...36,142,287
Ensembl chr 2:36,120,438...36,142,284 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions		 EXP Aluminum results in increased expression of PTGS2 mRNA; Aluminum results in increased expression of PTGS2 protein
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 mRNA]; meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 protein]		 CTD PMID:16928369 PMID:23690655 NCBI chr 1:149,975,851...149,983,978
Ensembl chr 1:149,975,782...149,983,978 		JBrowse link
G Pth parathyroid hormone multiple interactions ISO [TF protein binds to and results in increased uptake of Aluminum] which results in decreased secretion of PTH protein CTD PMID:10978387 NCBI chr 7:112,984,783...112,987,879
Ensembl chr 7:112,984,787...112,987,777 		JBrowse link
G Rcvrn recoverin multiple interactions ISO [APP protein modified form binds to Aluminum] which results in increased expression of RCVRN mRNA CTD PMID:21298039 NCBI chr11:67,586,152...67,594,181
Ensembl chr11:67,586,152...67,594,159 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) multiple interactions EXP [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein] CTD PMID:23690655 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Rpl37 ribosomal protein L37 decreases expression ISO Aluminum results in decreased expression of RPL37 mRNA; Aluminum results in decreased expression of RPL37 protein CTD PMID:27329587 NCBI chr15:5,146,127...5,148,626
Ensembl chr15:5,146,127...5,148,622 		JBrowse link
G Rtp4 receptor transporter protein 4 decreases expression EXP Aluminum results in decreased expression of RTP4 mRNA CTD PMID:37544489 NCBI chr16:23,338,976...23,432,972
Ensembl chr16:23,339,041...23,432,972 		JBrowse link
G S100b S100 protein, beta polypeptide, neural increases expression
multiple interactions		 ISO Aluminum results in increased expression of S100B protein
Vitamin E inhibits the reaction [Aluminum results in increased expression of S100B protein]		 CTD PMID:16545059 NCBI chr10:76,089,670...76,097,153
Ensembl chr10:76,089,687...76,096,993 		JBrowse link
G Scgb1a1 secretoglobin, family 1A, member 1 decreases expression ISO Aluminum results in decreased expression of SCGB1A1 protein CTD PMID:16052892 PMID:16099050 NCBI chr19:9,061,006...9,065,320
Ensembl chr19:9,061,000...9,065,322 		JBrowse link
G Shisa5 shisa family member 5 decreases expression EXP Aluminum results in decreased expression of SHISA5 mRNA CTD PMID:37544489 NCBI chr 9:108,867,635...108,886,860
Ensembl chr 9:108,867,633...108,886,845 		JBrowse link
G Slc2a1 solute carrier family 2 (facilitated glucose transporter), member 1 increases expression ISO Aluminum results in increased expression of SLC2A1 protein CTD PMID:16979867 NCBI chr 4:118,966,001...118,994,527
Ensembl chr 4:118,965,908...118,995,180 		JBrowse link
G Snai1 snail family zinc finger 1 multiple interactions ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNAI1 protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNAI1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNAI1 protein CTD PMID:32437896 NCBI chr 2:167,380,115...167,384,734
Ensembl chr 2:167,380,115...167,384,734 		JBrowse link
G Snca synuclein, alpha affects response to substance ISO SNCA protein affects the susceptibility to Aluminum CTD PMID:23106139 NCBI chr 6:60,708,557...60,806,839
Ensembl chr 6:60,708,559...60,806,839 		JBrowse link
G Sod2 superoxide dismutase 2, mitochondrial decreases activity ISO Aluminum results in decreased activity of SOD2 protein CTD PMID:19010380 NCBI chr17:13,226,726...13,237,006
Ensembl chr17:13,225,733...13,258,950 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression EXP Aluminum results in increased expression of SPP1 mRNA CTD PMID:37544489 NCBI chr 5:104,582,977...104,588,919
Ensembl chr 5:104,582,984...104,588,916 		JBrowse link
G Sprr1a small proline-rich protein 1A increases expression EXP Aluminum results in increased expression of SPRR1A mRNA CTD PMID:37544489 NCBI chr 3:92,391,261...92,393,188
Ensembl chr 3:92,391,259...92,393,202 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 protein; Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 mRNA] CTD PMID:34547296 NCBI chr11:50,090,979...50,105,303
Ensembl chr11:50,090,193...50,101,654 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression EXP Aluminum results in decreased expression of STAT1 mRNA; Aluminum results in decreased expression of STAT1 protein CTD PMID:37544489 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Tfrc transferrin receptor decreases expression
affects uptake		 ISO Aluminum results in decreased expression of TFRC mRNA
TFRC protein affects the uptake of Aluminum		 CTD PMID:9630424 PMID:11068183 NCBI chr16:32,427,714...32,451,612
Ensembl chr16:32,427,738...32,451,612 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of TGFB1 mRNA CTD PMID:32437896 NCBI chr 7:25,386,406...25,404,503
Ensembl chr 7:25,386,427...25,404,502 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions		 ISO
EXP		 Aluminum results in increased expression of TNF protein
[Titanium co-treated with Vanadium co-treated with Aluminum] results in increased expression of TNF mRNA
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of TNF protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Aluminum results in increased expression of TNF protein]
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]		 CTD PMID:16545059 PMID:17408380 PMID:23690655 PMID:27368151 PMID:29170048 More... NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Trf transferrin multiple interactions
affects binding
increases uptake		 ISO
EXP		 [Aluminum binds to TF protein] which results in decreased uptake of Iron; [Aluminum binds to TF protein] which results in decreased uptake of Manganese; [Aluminum binds to TF protein] which results in increased uptake of Aluminum; [TF protein binds to Aluminum] affects the activity of [TF protein binds to Iron]; [TF protein binds to Aluminum] which results in increased uptake of Aluminum; [TF protein binds to Aluminum] which results in increased uptake of Iron; [TF protein binds to and results in increased uptake of Aluminum] which results in decreased secretion of PTH protein; TF protein binds to [Aluminum co-treated with Iron]; TF protein binds to and results in increased uptake of Aluminum
TRF protein binds to Aluminum
Aluminum binds to TF protein; TF protein binds to Aluminum
TF protein results in increased uptake of Aluminum		 CTD PMID:1375080 PMID:2039817 PMID:2308257 PMID:8782865 PMID:10978387 More... NCBI chr 9:103,086,075...103,107,485
Ensembl chr 9:103,081,200...103,107,643 		JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions EXP [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of TUBB3 protein CTD PMID:31363819 NCBI chr 8:124,138,292...124,148,754
Ensembl chr 8:124,138,163...124,148,754 		JBrowse link
G Txn2 thioredoxin 2 multiple interactions ISO [aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of TXN2 protein CTD PMID:31945389 NCBI chr15:77,799,251...77,813,194
Ensembl chr15:77,799,247...77,813,206 		JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 decreases expression ISO Aluminum results in decreased expression of UBA52 mRNA; Aluminum results in decreased expression of UBA52 protein CTD PMID:27329587 NCBI chr 8:70,960,913...70,963,067
Ensembl chr 8:70,960,913...70,963,451 		JBrowse link
G Ube2l6 ubiquitin-conjugating enzyme E2L 6 decreases expression EXP Aluminum results in decreased expression of UBE2L6 mRNA CTD PMID:37544489 NCBI chr 2:84,629,172...84,640,347
Ensembl chr 2:84,629,172...84,640,679 		JBrowse link
G Usp18 ubiquitin specific peptidase 18 decreases expression EXP Aluminum results in decreased expression of USP18 mRNA CTD PMID:37544489 NCBI chr 6:121,222,865...121,247,876
Ensembl chr 6:121,222,865...121,247,876 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VEGFA protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of and results in increased secretion of VEGFA protein; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased secretion of VEGFA protein CTD PMID:32437896 NCBI chr17:46,327,919...46,343,303
Ensembl chr17:46,327,919...46,343,295 		JBrowse link
G Vim vimentin multiple interactions
increases expression		 ISO
EXP		 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VIM protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VIM mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VIM protein
Aluminum results in increased expression of VIM mRNA		 CTD PMID:32437896 PMID:37544489 NCBI chr 2:13,579,122...13,587,637
Ensembl chr 2:13,578,738...13,587,637 		JBrowse link
G Xaf1 XIAP associated factor 1 decreases expression EXP Aluminum results in decreased expression of XAF1 mRNA; Aluminum results in decreased expression of XAF1 protein CTD PMID:37544489 NCBI chr11:72,192,229...72,204,560
Ensembl chr11:72,192,455...72,204,559 		JBrowse link
G Xbp1 X-box binding protein 1 decreases expression EXP Aluminum results in decreased expression of XBP1 mRNA CTD PMID:37544489 NCBI chr11:5,470,641...5,475,993
Ensembl chr11:5,470,659...5,475,893 		JBrowse link
G Xdh xanthine dehydrogenase increases activity ISO Aluminum results in increased activity of XDH protein CTD PMID:11787993 NCBI chr17:74,190,890...74,257,191
Ensembl chr17:74,190,890...74,257,191 		JBrowse link
G Zbp1 Z-DNA binding protein 1 decreases expression EXP Aluminum results in decreased expression of ZBP1 mRNA CTD PMID:37544489 NCBI chr 2:173,048,405...173,060,715
Ensembl chr 2:173,048,405...173,060,716 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 22178
    chemical entity 22208
      molecular entity 22169
        inorganic molecular entity 21908
          elemental aluminium 149
            aluminium(0) 149
Path 2
Term Annotations click to browse term
  CHEBI ontology 22178
    subatomic particle 22170
      composite particle 22170
        hadron 22201
          baryon 22170
            nucleon 22170
              atomic nucleus 22170
                atom 22170
                  main group element atom 22104
                    main group molecular entity 22104
                      p-block molecular entity 22104
                        boron group molecular entity 1103
                          aluminium molecular entity 273
                            elemental aluminium 149
                              aluminium(0) 149
paths to the root