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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:elemental aluminium
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Accession:CHEBI:33628 term browser browse the term
Synonyms:related_synonym: elemental aluminum


show annotations for term's descendants           Sort by:
aluminium ion term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hmbs hydroxymethylbilane synthase decreases activity EXP Aluminium ion decreases activity of purified Hmbs protein RGD PMID:6732900 RGD:25394584 NCBI chr 8:53,570,364...53,577,758
Ensembl chr 8:53,570,364...53,577,802 		JBrowse link
aluminium trinitrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alad aminolevulinate dehydratase decreases activity EXP aluminum nitrate results in decreased activity of ALAD protein CTD PMID:8098681 NCBI chr 5:80,977,562...80,987,901
Ensembl chr 5:80,977,562...80,988,041 		JBrowse link
G Cat catalase decreases expression
multiple interactions 		EXP
ISO 		aluminum nitrate results in decreased expression of CAT mRNA; aluminum nitrate results in decreased expression of CAT protein
Silicon inhibits the reaction [aluminum nitrate results in decreased expression of CAT mRNA]; Silicon inhibits the reaction [aluminum nitrate results in decreased expression of CAT protein]
Silicic Acid inhibits the reaction [aluminum nitrate results in decreased expression of CAT mRNA] 		CTD PMID:18096288 PMID:29886234 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression
multiple interactions 		ISO aluminum nitrate results in increased expression of GPX1 mRNA
Silicic Acid inhibits the reaction [aluminum nitrate results in increased expression of GPX1 mRNA] 		CTD PMID:18096288 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gsr glutathione-disulfide reductase decreases expression
multiple interactions 		EXP aluminum nitrate results in decreased expression of GSR mRNA; aluminum nitrate results in decreased expression of GSR protein
Silicon inhibits the reaction [aluminum nitrate results in decreased expression of GSR mRNA]; Silicon inhibits the reaction [aluminum nitrate results in decreased expression of GSR protein] 		CTD PMID:29886234 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
decreases expression 		EXP Silicon inhibits the reaction [aluminum nitrate results in decreased expression of NFE2L2 mRNA] CTD PMID:29886234 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression 		ISO Silicic Acid inhibits the reaction [aluminum nitrate results in decreased expression of SOD1 mRNA] CTD PMID:18096288 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
decreases expression
multiple interactions 		EXP
ISO 		aluminum nitrate results in increased expression of SOD2 mRNA
aluminum nitrate results in decreased expression of SOD2 mRNA
Silicic Acid inhibits the reaction [aluminum nitrate results in decreased expression of SOD2 mRNA] 		CTD PMID:18096288 PMID:29886234 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression 		ISO
EXP 		Silicic Acid inhibits the reaction [aluminum nitrate results in increased expression of TNF mRNA]
aluminum nitrate results in increased expression of TNF protein 		CTD PMID:18096288 PMID:29886234 NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
aluminium(0) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace angiotensin I converting enzyme decreases activity ISO Aluminum results in decreased activity of ACE protein CTD PMID:12008977 NCBI chr10:91,410,129...91,430,246
Ensembl chr10:91,409,819...91,430,942 		JBrowse link
G Ache acetylcholinesterase multiple interactions
decreases activity 		EXP [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium co-treated with Zinc] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in increased activity of ACHE protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased activity of ACHE protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA; Aluminum promotes the reaction [Lead results in decreased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased activity of ACHE protein]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of ACHE mRNA]; Copper inhibits the reaction [Aluminum results in decreased activity of ACHE protein]; Plant Extracts inhibits the reaction [Aluminum results in decreased activity of ACHE protein] CTD PMID:15266904 PMID:23354609 PMID:24486960 PMID:29170048 PMID:37415728 NCBI chr12:25,042,882...25,050,608
Ensembl chr12:25,043,461...25,050,410 		JBrowse link
G Acly ATP citrate lyase multiple interactions ISO Aluminum results in increased expression of and results in increased activity of ACLY protein CTD PMID:17762189 NCBI chr10:85,912,402...85,964,605
Ensembl chr10:85,912,402...85,963,631 		JBrowse link
G Aco1 aconitase 1 decreases activity EXP Aluminum results in decreased activity of ACO1 protein CTD PMID:10806405 NCBI chr 5:60,055,895...60,111,920
Ensembl chr 5:60,055,866...60,112,600 		JBrowse link
G Aco2 aconitase 2 decreases activity
multiple interactions 		ISO
EXP 		Aluminum results in decreased activity of ACO2 protein
Aluminum promotes the reaction [Nitroprusside results in decreased activity of ACO2 protein]
Aluminum results in decreased expression of and results in decreased activity of ACO2 protein 		CTD PMID:12470706 PMID:16906525 PMID:19010380 NCBI chr 7:115,265,816...115,308,931
Ensembl chr 7:115,265,791...115,308,892 		JBrowse link
G Alb albumin affects binding ISO ALB protein binds to Aluminum CTD PMID:14507469 NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase multiple interactions
increases expression 		EXP caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 mRNA]; caffeic acid inhibits the reaction [Aluminum results in increased expression of ALOX5 protein]
Aluminum results in increased expression of ALOX5 mRNA; Aluminum results in increased expression of ALOX5 protein 		CTD PMID:27368151 NCBI chr 4:151,203,948...151,251,126
Ensembl chr 4:151,203,949...151,251,126 		JBrowse link
G Alpl alkaline phosphatase, biomineralization associated multiple interactions ISO [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of ALPL mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of ALPL mRNA] CTD PMID:34547296 NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:155,234,775...155,254,167 		JBrowse link
G Apob apolipoprotein B increases expression ISO Aluminum results in increased expression of APOB protein CTD PMID:17762189 NCBI chr 6:36,563,704...36,603,300
Ensembl chr 6:36,563,704...36,611,814 		JBrowse link
G App amyloid beta precursor protein affects binding
increases cleavage
increases expression
multiple interactions 		ISO
EXP 		APP protein binds to Aluminum
Aluminum results in increased cleavage of APP protein
Aluminum results in increased expression of APP protein
APP protein promotes the reaction [Aluminum results in decreased activity of CHAT protein]; meloxicam inhibits the reaction [Aluminum results in increased expression of APP protein]; Vitamin E inhibits the reaction [Aluminum results in increased cleavage of APP protein]
Aluminum results in increased expression of APP mRNA
[APP protein modified form binds to Aluminum] which results in increased expression of RCVRN mRNA
[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of APP mRNA] 		CTD PMID:12039845 PMID:16308480 PMID:16724269 PMID:16928369 PMID:16942756 More... NCBI chr11:37,506,207...37,724,351
Ensembl chr11:37,506,408...37,722,971 		JBrowse link
G Atxn3 ataxin 3 affects folding
multiple interactions 		ISO Aluminum affects the folding of ATXN3 protein polymorphism
Aluminum promotes the reaction [ATXN3 protein polymorphism binds to ATXN3 protein polymorphism] 		CTD PMID:17300980 NCBI chr 6:126,837,107...126,872,919
Ensembl chr 6:126,839,327...126,872,781 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator affects response to substance
multiple interactions 		EXP
ISO 		BAX protein affects the susceptibility to Aluminum
[aluminum chlorhydrate results in increased abundance of Aluminum] which affects the expression of BAX protein
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of BAX protein] 		CTD PMID:20385067 PMID:31945389 PMID:34547296 NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429 		JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 multiple interactions
decreases expression 		ISO Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]; Ketoglutaric Acids inhibits the reaction [Aluminum inhibits the reaction [BBOX1 protein results in increased chemical synthesis of Carnitine]]
Aluminum results in decreased expression of BBOX1 protein 		CTD PMID:21439360 NCBI chr 3:117,277,226...117,326,383
Ensembl chr 3:117,277,226...117,326,064 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein; Fulvestrant inhibits the reaction [[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein]
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BCL2 protein] 		CTD PMID:31945389 PMID:34547296 NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO [aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of BCL2L1 protein CTD PMID:31945389 NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:161,745,540...161,764,907
Ensembl chr 1:161,745,540...161,764,907 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions
decreases secretion 		EXP
ISO 		Aluminum inhibits the reaction [Calcitriol results in increased secretion of BGLAP protein]; Calcitriol inhibits the reaction [Aluminum results in decreased secretion of BGLAP protein]
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of BGLAP protein] 		CTD PMID:9626627 PMID:34547296 NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:176,136,341...176,137,318 		JBrowse link
G Bgn biglycan increases expression ISO Aluminum results in increased expression of BGN mRNA CTD PMID:37544489 NCBI chr  X:156,348,633...156,360,797
Ensembl chr  X:156,348,615...156,360,799 		JBrowse link
G Cald1 caldesmon 1 increases expression ISO Aluminum results in increased expression of CALD1 mRNA CTD PMID:37544489 NCBI chr 4:64,232,906...64,414,085
Ensembl chr 4:64,233,171...64,414,085 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO [aluminum chloride results in increased abundance of Aluminum] which results in increased expression of CASP12 mRNA CTD PMID:29635646 NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:10,926,994...10,954,442 		JBrowse link
G Casp3 caspase 3 increases expression
multiple interactions 		ISO
EXP 		Aluminum results in increased expression of CASP3
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased cleavage of CASP3 protein; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CASP3 mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased cleavage of CASP3 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CASP3 mRNA]
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of CASP3 protein 		CTD PMID:21972528 PMID:34547296 PMID:37415728 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO [aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of CASP9 protein; Fulvestrant inhibits the reaction [[aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of CASP9 protein] CTD PMID:31945389 Ensembl chr 5:159,391,188...159,409,648 JBrowse link
G Casr calcium-sensing receptor multiple interactions EXP [Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium; [Aluminum binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates; Aluminum binds to and results in increased activity of CASR protein CTD PMID:10231437 NCBI chr11:77,738,398...77,813,639
Ensembl chr11:77,740,614...77,810,167 		JBrowse link
G Cat catalase decreases activity
multiple interactions 		ISO
EXP 		Aluminum results in decreased activity of CAT protein
Vitamin E inhibits the reaction [Aluminum results in decreased activity of CAT protein]
[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased activity of CAT protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased activity of CAT protein; CAT protein results in decreased susceptibility to [Tyramine co-treated with Aluminum]; Plant Extracts inhibits the reaction [Aluminum results in decreased activity of CAT protein]
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased activity of CAT protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased activity of CAT protein] 		CTD PMID:15526171 PMID:17709913 PMID:24486960 PMID:34547296 PMID:37415728 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526 		JBrowse link
G Ccl7 C-C motif chemokine ligand 7 decreases expression ISO Aluminum results in decreased expression of CCL7 mRNA CTD PMID:37544489 NCBI chr10:67,514,095...67,515,945
Ensembl chr10:67,514,091...67,515,947 		JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of CDH1 protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of CDH1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of CDH1 protein CTD PMID:32437896 NCBI chr19:51,402,178...51,471,572
Ensembl chr19:51,402,034...51,471,565 		JBrowse link
G Chat choline O-acetyltransferase decreases expression
decreases activity
multiple interactions 		ISO Aluminum results in decreased expression of CHAT protein
Aluminum results in decreased activity of CHAT protein
APP protein promotes the reaction [Aluminum results in decreased activity of CHAT protein]; meloxicam inhibits the reaction [Aluminum results in decreased expression of CHAT protein] 		CTD PMID:16724269 PMID:16928369 NCBI chr16:7,663,665...7,723,416
Ensembl chr16:7,663,665...7,723,416 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression 		ISO [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of COL1A1 mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of COL1A1 mRNA]
Aluminum results in decreased expression of COL1A1 mRNA 		CTD PMID:34547296 PMID:37544489 NCBI chr10:80,380,458...80,397,461
Ensembl chr10:80,380,453...80,397,460 		JBrowse link
G Crp C-reactive protein multiple interactions ISO [Zinc co-treated with Aluminum] results in increased expression of CRP protein; [Zinc co-treated with Copper co-treated with Aluminum] results in increased expression of CRP protein CTD PMID:27816692 NCBI chr13:87,694,062...87,695,978
Ensembl chr13:87,657,317...87,707,514 		JBrowse link
G Cx3cl1 C-X3-C motif chemokine ligand 1 increases expression ISO Aluminum results in increased expression of CX3CL1 mRNA CTD PMID:37544489 NCBI chr19:10,233,326...10,244,856
Ensembl chr19:10,233,329...10,242,999 		JBrowse link
G Cycs cytochrome c, somatic multiple interactions ISO [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CYCS mRNA; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of CYCS mRNA] CTD PMID:34547296 NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:80,982,668...80,984,816
Ensembl chr18:80,982,668...80,984,816 		JBrowse link
G Daxx death-domain associated protein increases expression ISO Aluminum results in increased expression of DAXX mRNA CTD PMID:16308480 NCBI chr20:4,971,973...4,978,062
Ensembl chr20:4,971,941...4,977,720 		JBrowse link
G Drd1 dopamine receptor D1 multiple interactions EXP Aluminum inhibits the reaction [SCH 23390 binds to DRD1 protein] CTD PMID:9109525 NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,545,111...10,567,166 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Aluminum inhibits the reaction [3-N-methylspiperone binds to DRD2 protein] CTD PMID:9109525 NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:58,605,403...58,669,339 		JBrowse link
G Ecm1 extracellular matrix protein 1 increases expression ISO Aluminum results in increased expression of ECM1 mRNA CTD PMID:37544489 NCBI chr 2:185,976,439...185,981,656
Ensembl chr 2:185,976,440...185,981,606 		JBrowse link
G Egln3 egl-9 family hypoxia-inducible factor 3 increases expression ISO Aluminum results in increased expression of EGLN3 mRNA; Aluminum results in increased expression of EGLN3 protein CTD PMID:37544489 NCBI chr 6:77,385,549...77,411,015
Ensembl chr 6:77,385,549...77,411,015 		JBrowse link
G Eno2 enolase 2 decreases activity ISO Aluminum results in decreased activity of ENO2 protein CTD PMID:11860913 NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:159,258,371...159,267,220 		JBrowse link
G Epor erythropoietin receptor affects expression ISO Aluminum affects the expression of EPOR protein CTD PMID:15777837 NCBI chr 8:28,765,738...28,770,371
Ensembl chr 8:28,765,746...28,770,322 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO [aluminum chlorhydrate results in increased abundance of Aluminum] inhibits the reaction [Estradiol results in increased phosphorylation of ESR1 protein]; [aluminum chlorhydrate results in increased abundance of Aluminum] inhibits the reaction [NRG1 protein results in increased phosphorylation of ESR1 protein]; [aluminum chlorhydrate results in increased abundance of Aluminum] which results in increased expression of ESR1 protein; [Estradiol co-treated with [aluminum chlorhydrate results in increased abundance of Aluminum]] results in increased expression of ESR1 protein CTD PMID:31945389 NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:43,644,392...43,900,354 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions ISO [[aluminum chlorhydrate results in increased abundance of Aluminum] co-treated with [Tretinoin co-treated with Estradiol]] affects the localization of ESR2 protein; [[aluminum chlorhydrate results in increased abundance of Aluminum] which co-treated with Tretinoin] results in decreased expression of and affects the localization of ESR2 protein; [aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of and affects the localization of ESR2 protein; [Estradiol co-treated with [aluminum chlorhydrate results in increased abundance of Aluminum]] results in decreased expression of ESR2 protein CTD PMID:31945389 NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:100,545,206...100,644,709 		JBrowse link
G F8 coagulation factor VIII affects folding
multiple interactions 		ISO Aluminum affects the folding of F8 protein
[Aluminum promotes the reaction [F8 protein binds to F8 protein]] which results in decreased activity of F8 protein 		CTD PMID:15349964 NCBI chr18:155,237...187,186
Ensembl chr18:155,309...186,683 		JBrowse link
G Fdft1 farnesyl diphosphate farnesyl transferase 1 increases expression ISO Aluminum results in increased expression of FDFT1 mRNA CTD PMID:37544489 NCBI chr15:41,588,114...41,616,168
Ensembl chr15:41,588,117...41,616,168 		JBrowse link
G Fh fumarate hydratase multiple interactions ISO Aluminum results in decreased expression of and results in decreased activity of FH protein CTD PMID:16906525 NCBI chr13:90,056,565...90,082,450
Ensembl chr13:90,056,570...90,089,627 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of FOS protein] CTD PMID:23690655 NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:110,852,190...110,855,598 		JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit increases expression ISO Aluminum results in increased expression of FOSL1 mRNA CTD PMID:37544489 NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:212,183,833...212,192,391 		JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases activity ISO
EXP 		Aluminum results in increased activity of G6PD protein CTD PMID:16572710 PMID:16979867 NCBI chr  X:157,352,364...157,372,144
Ensembl chr  X:157,352,373...157,372,144 		JBrowse link
G Gbp4 guanylate binding protein 4 decreases expression ISO Aluminum results in decreased expression of GBP3 mRNA CTD PMID:37544489 NCBI chr 2:233,978,163...233,992,124
Ensembl chr 2:233,978,486...233,992,120 		JBrowse link
G Gchfr GTP cyclohydrolase I feedback regulator increases expression ISO Aluminum results in increased expression of GCHFR mRNA CTD PMID:37544489 NCBI chr 3:126,611,892...126,615,926
Ensembl chr 3:126,613,240...126,615,926 		JBrowse link
G Gfap glial fibrillary acidic protein increases expression
multiple interactions 		EXP
ISO 		Aluminum results in increased expression of GFAP protein
Vitamin E inhibits the reaction [Aluminum results in increased expression of GFAP protein]
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of GFAP protein 		CTD PMID:16545059 PMID:31363819 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:88,352,986...88,361,685 		JBrowse link
G Gnai1 G protein subunit alpha i1 decreases expression EXP Aluminum results in decreased expression of GNAI1 protein CTD PMID:9626627 NCBI chr 4:17,706,061...17,790,176
Ensembl chr 4:17,706,025...17,789,198 		JBrowse link
G Gnai2 G protein subunit alpha i2 decreases expression EXP Aluminum results in decreased expression of GNAI2 protein CTD PMID:9626627 NCBI chr 8:117,167,045...117,187,652
Ensembl chr 8:117,167,045...117,187,622 		JBrowse link
G Gnaq G protein subunit alpha q increases response to substance ISO GNAQ protein results in increased susceptibility to Aluminum CTD PMID:15068510 NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:222,852,097...223,126,742 		JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 multiple interactions ISO Aluminum results in increased expression of and results in increased activity of GPD1 protein CTD PMID:17762189 NCBI chr 7:132,722,982...132,730,373
Ensembl chr 7:132,721,915...132,730,368 		JBrowse link
G Gpx1 glutathione peroxidase 1 decreases activity
multiple interactions 		ISO Aluminum results in decreased activity of GPX1 protein
Vitamin E inhibits the reaction [Aluminum results in decreased activity of GPX1 protein] 		CTD PMID:17709913 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gsr glutathione-disulfide reductase decreases expression
multiple interactions 		EXP Aluminum results in decreased expression of GSR protein
Plant Extracts inhibits the reaction [Aluminum results in decreased expression of GSR protein] 		CTD PMID:24486960 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G H2ax H2A.X variant histone multiple interactions ISO [erionite results in increased abundance of Aluminum] which results in increased phosphorylation of H2AX protein CTD PMID:38605572 NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha increases localization ISO Aluminum results in increased localization of HIF1A protein CTD PMID:16979867 NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323 		JBrowse link
G Hk1 hexokinase 1 multiple interactions
decreases activity 		EXP Meclofenoxate inhibits the reaction [Aluminum results in decreased activity of HK1 protein] CTD PMID:16969689 NCBI chr20:30,773,222...30,874,814
Ensembl chr20:30,773,220...30,874,814 		JBrowse link
G Hmga1 high mobility group AT-hook 1 increases expression ISO Aluminum results in increased expression of HMGA1 mRNA CTD PMID:37544489 NCBI chr20:5,612,902...5,620,596
Ensembl chr20:5,613,471...5,620,593 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO [erionite results in increased abundance of Aluminum] which results in increased expression of ICAM1 mRNA CTD PMID:38605572 NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:27,829,161...27,841,617 		JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 decreases activity EXP Aluminum results in decreased activity of IDH1 protein CTD PMID:15486972 NCBI chr 9:74,027,887...74,057,442
Ensembl chr 9:74,027,892...74,049,555 		JBrowse link
G Idh2 isocitrate dehydrogenase (NADP(+)) 2 decreases activity EXP Aluminum results in decreased activity of IDH2 protein CTD PMID:15486972 NCBI chr 1:143,447,925...143,467,248
Ensembl chr 1:143,439,323...143,467,248 		JBrowse link
G Ifi27l2a interferon, alpha-inducible protein 27 like 2A decreases expression ISO Aluminum results in decreased expression of IFI27L2A mRNA CTD PMID:37544489 NCBI chr 6:128,363,658...128,365,144
Ensembl chr 6:128,363,658...128,365,146 		JBrowse link
G Ifi35 interferon-induced protein 35 decreases expression ISO Aluminum results in decreased expression of IFI35 mRNA CTD PMID:37544489 NCBI chr10:86,881,270...86,889,523
Ensembl chr10:86,887,122...86,889,750 		JBrowse link
G Ifit1 interferon-induced protein with tetratricopeptide repeats 1 decreases expression ISO Aluminum results in decreased expression of IFIT1 mRNA CTD PMID:37544489 NCBI chr 1:241,565,197...241,567,262
Ensembl chr 1:241,543,184...241,568,148 		JBrowse link
G Ifit3 interferon-induced protein with tetratricopeptide repeats 3 decreases expression ISO Aluminum results in decreased expression of IFIT3 mRNA CTD PMID:37544489 NCBI chr 1:241,527,326...241,532,469
Ensembl chr 1:241,526,880...241,532,521 		JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IFNB1 mRNA] CTD PMID:23690655 NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:108,066,650...108,067,487 		JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Aluminum inhibits the reaction [IGF1 protein results in increased activity of MTR protein] CTD PMID:14745455 NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:24,130,137...24,246,764 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12B mRNA] CTD PMID:23690655 NCBI chr10:29,390,300...29,405,194
Ensembl chr10:29,389,905...29,405,194 		JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression 		EXP
ISO 		[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL1B protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of IL1B protein]; Vitamin E inhibits the reaction [Aluminum results in increased expression of IL1B protein]
[erionite results in increased abundance of Aluminum] which results in decreased expression of IL1B mRNA; [erionite results in increased abundance of Aluminum] which results in decreased secretion of IL1B protein 		CTD PMID:16545059 PMID:27368151 PMID:29170048 PMID:38605572 NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601 		JBrowse link
G Il4 interleukin 4 increases expression ISO Aluminum results in increased expression of IL4 mRNA CTD PMID:16630673 NCBI chr10:38,272,003...38,277,549
Ensembl chr10:38,272,003...38,277,549 		JBrowse link
G Il6 interleukin 6 multiple interactions
increases expression 		EXP
ISO 		[Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of IL6 protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of IL6 protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of IL6 protein]
[erionite results in increased abundance of Aluminum] which results in increased expression of IL6 mRNA; [Zinc co-treated with Aluminum] results in increased expression of IL6 protein; [Zinc co-treated with Copper co-treated with Aluminum] results in increased expression of IL6 protein 		CTD PMID:27368151 PMID:27816692 PMID:29170048 PMID:37415728 PMID:38605572 NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610 		JBrowse link
G Irf7 interferon regulatory factor 7 decreases expression ISO Aluminum results in decreased expression of IRF7 mRNA CTD PMID:37544489 NCBI chr 1:205,796,956...205,800,543
Ensembl chr 1:205,796,959...205,800,023 		JBrowse link
G Isg15 ISG15 ubiquitin-like modifier decreases expression ISO Aluminum results in decreased expression of ISG15 mRNA CTD PMID:37544489 NCBI chr 5:172,066,369...172,067,656
Ensembl chr 5:172,066,369...172,067,656 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of JUN protein] CTD PMID:23690655 NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285 		JBrowse link
G Klk1 kallikrein 1 multiple interactions ISO Aluminum binds to and results in decreased activity of KLK1 protein CTD PMID:15558947 NCBI chr 1:103,779,152...103,783,270
Ensembl chr 1:103,779,164...103,783,270 		JBrowse link
G Litaf lipopolysaccharide-induced TNF factor multiple interactions ISO [Titanium co-treated with Vanadium co-treated with Aluminum] results in increased expression of LITAF mRNA CTD PMID:17408380 NCBI chr10:5,163,258...5,199,930
Ensembl chr10:5,163,242...5,199,930 		JBrowse link
G Lonrf2 LON peptidase N-terminal domain and ring finger 2 decreases expression EXP Aluminum results in decreased expression of LONRF2 mRNA CTD PMID:19010380 NCBI chr 9:48,524,962...48,566,353
Ensembl chr 9:48,530,549...48,570,807 		JBrowse link
G Manf mesencephalic astrocyte-derived neurotrophic factor decreases expression ISO Aluminum results in decreased expression of MANF mRNA; Aluminum results in decreased expression of MANF protein CTD PMID:37544489 NCBI chr 8:116,427,053...116,430,259
Ensembl chr 8:116,427,048...116,429,910 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MAP1LC3B mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased lipidation of MAP1LC3B protein; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MAP1LC3B mRNA]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased lipidation of MAP1LC3B protein] CTD PMID:34547296 NCBI chr19:66,571,631...66,582,270
Ensembl chr19:66,574,407...66,584,358
Ensembl chr16:66,574,407...66,584,358 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP [Aluminum co-treated with Iron] results in increased phosphorylation of MAPK3 protein CTD PMID:16728372 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mapt microtubule-associated protein tau increases phosphorylation
multiple interactions 		EXP Aluminum results in increased phosphorylation of MAPT protein
[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of MAPT mRNA] 		CTD PMID:17662457 PMID:29170048 NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,638,599...89,736,108 		JBrowse link
G Mir21 microRNA 21 multiple interactions ISO [Air Pollutants, Occupational results in increased abundance of Aluminum] which results in increased expression of MIR21 mRNA CTD PMID:27506416 NCBI chr10:71,902,600...71,902,691 JBrowse link
G Mir30d microRNA 30d multiple interactions ISO [Air Pollutants, Occupational results in increased abundance of Aluminum] which results in increased expression of MIR30D mRNA CTD PMID:27506416 NCBI chr 7:102,025,345...102,025,426 JBrowse link
G Mir322 microRNA 322 multiple interactions ISO [Air Pollutants, Occupational results in increased abundance of Aluminum] which results in increased expression of MIR424 mRNA CTD PMID:27506416 NCBI chr  X:137,726,147...137,726,241 JBrowse link
G Mmp2 matrix metallopeptidase 2 increases expression EXP Aluminum results in increased expression of MMP2 protein CTD PMID:16052892 NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856 		JBrowse link
G Mmp7 matrix metallopeptidase 7 multiple interactions ISO [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MMP7 mRNA CTD PMID:32437896 NCBI chr 8:13,133,043...13,140,761
Ensembl chr 8:13,133,043...13,140,755 		JBrowse link
G Mmp9 matrix metallopeptidase 9 increases expression
multiple interactions 		EXP
ISO 		Aluminum results in increased expression of MMP9 protein
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of MMP9 mRNA 		CTD PMID:16052892 PMID:32437896 NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442 		JBrowse link
G Mpo myeloperoxidase increases expression ISO Aluminum results in increased expression of MPO protein CTD PMID:17402216 NCBI chr10:73,092,124...73,102,057
Ensembl chr10:73,092,400...73,102,056 		JBrowse link
G Mrpl20 mitochondrial ribosomal protein L20 decreases expression ISO Aluminum results in decreased expression of MRPL20 mRNA CTD PMID:37544489 NCBI chr 5:171,690,664...171,695,728
Ensembl chr 5:171,691,198...171,695,728 		JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression ISO Aluminum results in increased expression of MSMO1 mRNA CTD PMID:37544489 NCBI chr16:29,747,113...29,764,360
Ensembl chr16:29,747,137...29,764,445 		JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase multiple interactions ISO Aluminum inhibits the reaction [[Hydroxocobalamin co-treated with S-Adenosylmethionine] results in increased activity of MTR protein alternative form]; Aluminum inhibits the reaction [IGF1 protein results in increased activity of MTR protein]; Aluminum inhibits the reaction [mecobalamin results in increased activity of MTR protein alternative form] CTD PMID:14745455 PMID:26989453 NCBI chr17:62,911,705...62,996,544
Ensembl chr17:62,911,771...62,996,541 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression ISO Aluminum results in increased expression of MYC mRNA; Aluminum results in increased expression of MYC protein CTD PMID:37544489 NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:95,483,105...95,488,028 		JBrowse link
G Nes nestin multiple interactions EXP [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of NES protein; Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of NES protein] CTD PMID:32959702 NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:175,736,551...175,746,228 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Selenium] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFE2L2 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFE2L2 protein CTD PMID:37415728 NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:81,001,529...81,029,090 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions EXP [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese co-treated with Zinc] results in decreased expression of NFKB1 protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in decreased expression of NFKB1 protein CTD PMID:37415728 NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:226,689,745...226,783,088 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP
ISO 		[Aluminum co-treated with Iron] results in increased expression of NOS2 protein
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA] 		CTD PMID:16728372 PMID:23690655 NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880 		JBrowse link
G Nrg1 neuregulin 1 multiple interactions ISO [aluminum chlorhydrate results in increased abundance of Aluminum] inhibits the reaction [NRG1 protein results in increased phosphorylation of ESR1 protein] CTD PMID:31945389 NCBI chr16:65,954,084...67,007,484
Ensembl chr16:65,953,865...66,999,849 		JBrowse link
G Oas1a 2'-5' oligoadenylate synthetase 1A decreases expression ISO Aluminum results in decreased expression of OAS1G mRNA CTD PMID:37544489 NCBI chr12:41,330,423...41,341,130
Ensembl chr12:41,285,211...41,341,128 		JBrowse link
G Ogdh oxoglutarate dehydrogenase multiple interactions
increases activity 		ISO
EXP 		Aluminum results in decreased expression of and results in decreased activity of OGDH protein
Aluminum results in increased activity of OGDH protein 		CTD PMID:10806405 PMID:16906525 NCBI chr14:85,363,949...85,431,405
Ensembl chr14:85,364,014...85,432,271 		JBrowse link
G Oprd1 opioid receptor, delta 1 multiple interactions EXP [Enkephalin, D-Penicillamine (2,5)- binds to and results in increased activity of OPRD1 protein] which results in decreased abundance of Aluminum CTD PMID:7477890 NCBI chr 5:149,590,244...149,624,999
Ensembl chr 5:149,590,244...149,624,999 		JBrowse link
G Parp10 poly (ADP-ribose) polymerase family, member 10 decreases expression ISO Aluminum results in decreased expression of PARP10 mRNA CTD PMID:37544489 NCBI chr 7:109,829,721...109,839,054
Ensembl chr 7:109,829,722...109,843,566 		JBrowse link
G Parp9 poly (ADP-ribose) polymerase family, member 9 decreases expression ISO Aluminum results in decreased expression of PARP9 mRNA; Aluminum results in decreased expression of PARP9 protein CTD PMID:37544489 NCBI chr11:78,286,282...78,320,409
Ensembl chr11:78,286,287...78,320,608 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions ISO [aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of PCK1 protein CTD PMID:31945389 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO [aluminum chloride results in increased abundance of Aluminum] which results in decreased expression of PCNA mRNA CTD PMID:29635646 NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:139,951,941...139,955,901 		JBrowse link
G Pcyt2 phosphate cytidylyltransferase 2, ethanolamine increases expression ISO Aluminum results in increased expression of PCYT2 mRNA CTD PMID:37544489 NCBI chr10:106,387,150...106,394,500
Ensembl chr10:106,387,148...106,394,468 		JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 protein; Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PINK1 mRNA] CTD PMID:34547296 NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:155,813,838...155,825,950 		JBrowse link
G Pklr pyruvate kinase L/R increases activity ISO Aluminum results in increased activity of PKLR protein CTD PMID:16979867 NCBI chr 2:176,840,779...176,849,637
Ensembl chr 2:176,840,764...176,849,644 		JBrowse link
G Plcd1 phospholipase C, delta 1 increases expression EXP Aluminum results in increased expression of PLCD1 protein CTD PMID:10814511 NCBI chr 8:127,672,955...127,695,939
Ensembl chr 8:127,672,980...127,695,939 		JBrowse link
G Prkg2 protein kinase cGMP-dependent 2 increases expression ISO Aluminum results in increased expression of PRKG2 mRNA CTD PMID:37544489 NCBI chr14:10,864,020...10,972,617
Ensembl chr14:10,864,186...10,972,614 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN protein; Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of PRKN mRNA] CTD PMID:34547296 NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:51,210,330...52,430,304 		JBrowse link
G Psmb8 proteasome 20S subunit beta 8 decreases expression ISO Aluminum results in decreased expression of PSMB8 mRNA; Aluminum results in decreased expression of PSMB8 protein CTD PMID:37544489 NCBI chr20:4,654,068...4,657,049
Ensembl chr20:4,654,068...4,657,031 		JBrowse link
G Ptgs1 prostaglandin-endoperoxide synthase 1 increases expression ISO Aluminum results in increased expression of PTGS1 mRNA; Aluminum results in increased expression of PTGS1 protein CTD PMID:37544489 NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression
multiple interactions 		ISO Aluminum results in increased expression of PTGS2 mRNA; Aluminum results in increased expression of PTGS2 protein
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 mRNA]; meloxicam inhibits the reaction [Aluminum results in increased expression of PTGS2 protein] 		CTD PMID:16928369 PMID:23690655 NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320 		JBrowse link
G Pth parathyroid hormone multiple interactions ISO [TF protein binds to and results in increased uptake of Aluminum] which results in decreased secretion of PTH protein CTD PMID:10978387 NCBI chr 1:176,942,901...176,946,034
Ensembl chr 1:176,943,102...176,946,034 		JBrowse link
G Rcvrn recoverin multiple interactions ISO [APP protein modified form binds to Aluminum] which results in increased expression of RCVRN mRNA CTD PMID:21298039 NCBI chr10:52,887,667...52,895,413
Ensembl chr10:52,887,468...52,895,413 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO [Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein] CTD PMID:23690655 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Rpl37 ribosomal protein L37 decreases expression ISO Aluminum results in decreased expression of RPL37 mRNA; Aluminum results in decreased expression of RPL37 protein CTD PMID:27329587 NCBI chr 2:55,942,827...55,944,905
Ensembl chr 2:55,942,945...55,944,900 		JBrowse link
G Rtp4 receptor (chemosensory) transporter protein 4 decreases expression ISO Aluminum results in decreased expression of RTP4 mRNA CTD PMID:37544489 NCBI chr11:90,741,992...90,840,061
Ensembl chr11:90,741,992...90,753,851 		JBrowse link
G S100b S100 calcium binding protein B increases expression
multiple interactions 		EXP Aluminum results in increased expression of S100B protein
Vitamin E inhibits the reaction [Aluminum results in increased expression of S100B protein] 		CTD PMID:16545059 NCBI chr20:12,372,345...12,381,159
Ensembl chr20:12,372,348...12,381,081 		JBrowse link
G Scgb1a1 secretoglobin family 1A member 1 decreases expression EXP
ISO 		Aluminum results in decreased expression of SCGB1A1 protein CTD PMID:16052892 PMID:16099050 NCBI chr 1:215,406,138...215,409,686
Ensembl chr 1:215,406,138...215,409,686 		JBrowse link
G Shisa5 shisa family member 5 decreases expression ISO Aluminum results in decreased expression of SHISA5 mRNA CTD PMID:37544489 NCBI chr 8:118,569,975...118,584,880
Ensembl chr 8:118,569,975...118,584,880 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 increases expression ISO Aluminum results in increased expression of SLC2A1 protein CTD PMID:16979867 NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:138,002,522...138,030,742 		JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNAI1 protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNAI1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNAI1 protein CTD PMID:32437896 NCBI chr 3:176,667,476...176,671,965 JBrowse link
G Snca synuclein alpha affects response to substance
multiple interactions 		ISO
EXP 		SNCA protein affects the susceptibility to Aluminum
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNCA protein; Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of SNCA protein] 		CTD PMID:23106139 PMID:32959702 NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:91,026,474...91,126,315 		JBrowse link
G Sod2 superoxide dismutase 2 decreases activity EXP Aluminum results in decreased activity of SOD2 protein CTD PMID:19010380 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Spp1 secreted phosphoprotein 1 increases expression ISO Aluminum results in increased expression of SPP1 mRNA CTD PMID:37544489 NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,613,576...5,619,820 		JBrowse link
G Sprr1a small proline-rich protein 1A increases expression ISO Aluminum results in increased expression of SPRR1A mRNA CTD PMID:37544489 NCBI chr 2:180,750,709...180,752,625
Ensembl chr 2:180,750,709...180,752,991 		JBrowse link
G Sqstm1 sequestosome 1 multiple interactions ISO [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 protein; Acetylcholine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 protein]; Acetylcysteine inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of SQSTM1 mRNA] CTD PMID:34547296 NCBI chr10:35,026,598...35,037,750
Ensembl chr10:35,026,598...35,037,750 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 decreases expression ISO Aluminum results in decreased expression of STAT1 mRNA; Aluminum results in decreased expression of STAT1 protein CTD PMID:37544489 NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:56,911,523...57,077,346 		JBrowse link
G Tf transferrin multiple interactions
increases uptake
affects binding 		ISO [Aluminum binds to TF protein] which results in decreased uptake of Iron; [Aluminum binds to TF protein] which results in decreased uptake of Manganese; [Aluminum binds to TF protein] which results in increased uptake of Aluminum; [TF protein binds to Aluminum] affects the activity of [TF protein binds to Iron]; [TF protein binds to Aluminum] which results in increased uptake of Aluminum; [TF protein binds to Aluminum] which results in increased uptake of Iron; [TF protein binds to and results in increased uptake of Aluminum] which results in decreased secretion of PTH protein; TF protein binds to [Aluminum co-treated with Iron]; TF protein binds to and results in increased uptake of Aluminum
TF protein results in increased uptake of Aluminum
Aluminum binds to TF protein; TF protein binds to Aluminum
TRF protein binds to Aluminum 		CTD PMID:1375080 PMID:2039817 PMID:2308257 PMID:8782865 PMID:10978387 More... NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:112,647,642...112,695,400 		JBrowse link
G Tfrc transferrin receptor decreases expression
affects uptake 		EXP Aluminum results in decreased expression of TFRC mRNA
TFRC protein affects the uptake of Aluminum 		CTD PMID:9630424 PMID:11068183 NCBI chr11:81,668,478...81,690,318
Ensembl chr11:81,668,478...81,690,318 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of TGFB1 mRNA CTD PMID:32437896 NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:90,324,046...90,340,899 		JBrowse link
G Tnf tumor necrosis factor increases expression
multiple interactions 		EXP
ISO 		Aluminum results in increased expression of TNF protein
[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]
[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of TNF protein; [Aluminum co-treated with Lead co-treated with Mercury co-treated with Manganese] results in increased expression of TNF protein; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA; [Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF mRNA]; Berberine inhibits the reaction [[Cadmium co-treated with Aluminum co-treated with Fluorides] results in increased expression of TNF protein]; caffeic acid inhibits the reaction [Aluminum results in increased expression of TNF protein]; Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of TNF protein]; Vitamin E inhibits the reaction [Aluminum results in increased expression of TNF protein]
[erionite results in increased abundance of Aluminum] which results in increased secretion of TNF protein; [Titanium co-treated with Vanadium co-treated with Aluminum] results in increased expression of TNF mRNA 		CTD PMID:16545059 PMID:17408380 PMID:23690655 PMID:27368151 PMID:29170048 More... NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303 		JBrowse link
G Tubb3 tubulin, beta 3 class III multiple interactions ISO [Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of TUBB3 protein CTD PMID:31363819 NCBI chr19:68,365,687...68,374,741
Ensembl chr19:68,365,587...68,374,740 		JBrowse link
G Txn2 thioredoxin 2 multiple interactions ISO [aluminum chlorhydrate results in increased abundance of Aluminum] which results in decreased expression of TXN2 protein CTD PMID:31945389 NCBI chr 7:111,377,338...111,390,940
Ensembl chr 7:111,386,805...111,390,022 		JBrowse link
G Uba52 ubiquitin A-52 residue ribosomal protein fusion product 1 decreases expression ISO Aluminum results in decreased expression of UBA52 mRNA; Aluminum results in decreased expression of UBA52 protein CTD PMID:27329587 NCBI chr16:18,952,583...18,954,780 JBrowse link
G Ube2l6 ubiquitin-conjugating enzyme E2L 6 decreases expression ISO Aluminum results in decreased expression of UBE2L6 mRNA CTD PMID:37544489 NCBI chr 3:90,279,705...90,294,721
Ensembl chr 3:90,279,668...90,294,717 		JBrowse link
G Usp18 ubiquitin specific peptidase 18 decreases expression ISO Aluminum results in decreased expression of USP18 mRNA CTD PMID:37544489 NCBI chr 4:156,143,770...156,171,292
Ensembl chr 4:156,143,815...156,171,292 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VCAM1 protein; Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VCAM1 protein] CTD PMID:32959702 NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:206,723,044...206,742,801 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO
EXP 		4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VEGFA protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of and results in increased secretion of VEGFA protein; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased secretion of VEGFA protein
[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of VEGFA protein; Sildenafil Citrate inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in decreased expression of VEGFA protein] 		CTD PMID:32437896 PMID:32959702 NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194 		JBrowse link
G Vim vimentin multiple interactions
increases expression 		ISO 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide inhibits the reaction [[Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VIM protein]; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VIM mRNA; [Aluminum Chloride results in increased abundance of Aluminum] which results in increased expression of VIM protein
Aluminum results in increased expression of VIM mRNA 		CTD PMID:32437896 PMID:37544489 NCBI chr17:81,577,261...81,585,746
Ensembl chr17:81,568,272...81,585,746 		JBrowse link
G Xaf1 XIAP associated factor 1 decreases expression ISO Aluminum results in decreased expression of XAF1 mRNA; Aluminum results in decreased expression of XAF1 protein CTD PMID:37544489 NCBI chr10:57,415,935...57,428,348
Ensembl chr10:57,415,658...57,428,349 		JBrowse link
G Xbp1 X-box binding protein 1 decreases expression ISO Aluminum results in decreased expression of XBP1 mRNA CTD PMID:37544489 NCBI chr14:84,604,623...84,609,707
Ensembl chr14:84,604,107...84,609,706 		JBrowse link
G Xdh xanthine dehydrogenase increases activity EXP Aluminum results in increased activity of XDH protein CTD PMID:11787993 NCBI chr 6:27,282,319...27,344,022
Ensembl chr 6:27,282,057...27,344,350 		JBrowse link
G Zbp1 Z-DNA binding protein 1 decreases expression ISO Aluminum results in decreased expression of ZBP1 mRNA CTD PMID:37544489 NCBI chr 3:182,411,665...182,427,604
Ensembl chr 3:182,411,665...182,422,839 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20862
    chemical entity 20860
      molecular entity 20859
        inorganic molecular entity 20593
          elemental aluminium 148
            aluminium ion + 9
            aluminium(0) 145
            diatomic aluminium + 0
            monoatomic aluminium + 8
            tetraatomic aluminium + 0
            triatomic aluminium + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20862
    subatomic particle 20860
      composite particle 20860
        hadron 20860
          baryon 20860
            nucleon 20860
              atomic nucleus 20860
                atom 20860
                  main group element atom 20781
                    p-block element atom 20781
                      p-block molecular entity 20781
                        boron group molecular entity 1166
                          aluminium molecular entity 293
                            elemental aluminium 148
                              aluminium ion + 9
                              aluminium(0) 145
                              diatomic aluminium + 0
                              monoatomic aluminium + 8
                              tetraatomic aluminium + 0
                              triatomic aluminium + 0
paths to the root