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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Cannabinol
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Accession:CHEBI:3360 term browser browse the term
Definition:A dibenzopyran that has formula C21H26O2.
Synonyms:related_synonym: Formula=C21H26O2;   InChI=1S/C21H26O2/c1-5-6-7-8-15-12-18(22)20-16-11-14(2)9-10-17(16)21(3,4)23-19(20)13-15/h9-13,22H,5-8H2,1-4H3;   InChIKey=VBGLYOIFKLUMQG-UHFFFAOYSA-N;   SMILES=CCCCCc1cc(O)c-2c(OC(C)(C)c3ccc(C)cc-23)c1
 xref: CAS:521-35-7;   KEGG:C07580
 xref_mesh: MESH:D002187



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Cannabinol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 (ABCC1 blood group) decreases activity EXP Cannabinol results in decreased activity of ABCC1 protein CTD PMID:18619955 NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257
JBrowse link
G CNR1 cannabinoid receptor 1 affects binding ISO Cannabinol binds to CNR1 protein CTD PMID:19679411 NCBI chr 6:88,139,864...88,167,349
Ensembl chr 6:88,139,864...88,166,347
JBrowse link
G CYP2J2 cytochrome P450 family 2 subfamily J member 2 increases metabolic processing
multiple interactions
EXP CYP2J2 protein results in increased metabolism of Cannabinol
Cannabinol inhibits the reaction [CYP2J2 protein results in increased metabolism of anandamide]
CTD PMID:29689453 NCBI chr 1:59,893,308...59,969,212
Ensembl chr 1:59,893,308...59,926,773
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Cannabinol inhibits the reaction [[JUN protein binds to FOS protein] which binds to IL2 promoter]; Cannabinol results in decreased expression of and affects the localization of FOS protein CTD PMID:10670588 NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230
JBrowse link
G IFNG interferon gamma multiple interactions ISO Cannabinol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Rimonabant inhibits the reaction [Cannabinol inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]] CTD PMID:11520904 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740
JBrowse link
G IL2 interleukin 2 multiple interactions ISO Cannabinol inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of IL2 mRNA]; Cannabinol inhibits the reaction [[Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in increased secretion of IL2 protein]; Cannabinol inhibits the reaction [[JUN protein binds to FOS protein] which binds to IL2 promoter]; Cannabinol promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of IL2 mRNA]; Cannabinol promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL2 protein]; KN 93 inhibits the reaction [Cannabinol promotes the reaction [Tetradecanoylphorbol Acetate results in increased secretion of IL2 protein]] CTD PMID:8662742 PMID:10670588 PMID:11809870 NCBI chr 4:122,451,470...122,456,725
Ensembl chr 4:122,451,470...122,456,725
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Cannabinol inhibits the reaction [[JUN protein binds to FOS protein] which binds to IL2 promoter]; Cannabinol results in decreased expression of and affects the localization of JUN protein CTD PMID:10670588 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048
JBrowse link
G PRL prolactin multiple interactions EXP Cannabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased expression of PRL mRNA]; Cannabinol inhibits the reaction [[Medroxyprogesterone Acetate co-treated with Estradiol co-treated with Colforsin] results in increased secretion of PRL protein] CTD PMID:31154070 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions ISO Cannabinol inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of and results in increased activity of STAT1 protein] CTD PMID:19910459 NCBI chr 2:190,969,149...191,014,171
Ensembl chr 2:190,908,460...191,020,960
JBrowse link
G TRPA1 transient receptor potential cation channel subfamily A member 1 multiple interactions
increases activity
EXP [Cannabinol results in increased activity of TRPA1 protein] which results in increased uptake of Calcium CTD PMID:31096838 NCBI chr 8:72,021,250...72,090,010
Ensembl chr 8:72,019,917...72,075,584
JBrowse link
G TRPV2 transient receptor potential cation channel subfamily V member 2 multiple interactions ISO Cannabinol binds to and results in increased activity of TRPV2 protein CTD PMID:18550765 NCBI chr17:16,415,571...16,437,003
Ensembl chr17:16,415,571...16,437,003
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    chemical entity 26024
      atom 26009
        nonmetal atom 25498
          oxygen atom 24817
            oxygen molecular entity 24806
              organooxygen compound 24054
                oxacycle 19986
                  dibenzopyran 288
                    Cannabinol 11
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    main group molecular entity 25834
                      p-block molecular entity 25829
                        carbon group molecular entity 25434
                          organic molecular entity 25392
                            organic molecule 25222
                              organic cyclic compound 24274
                                organic heterocyclic compound 22328
                                  organic heteropolycyclic compound 21329
                                    dibenzopyran 288
                                      Cannabinol 11
paths to the root