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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:spiro compound
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Accession:CHEBI:33599 term browser browse the term
Definition:A compound having one atom as the only common member of two rings.
Synonyms:exact_synonym: spiro compounds
 related_synonym: spiro-fused compounds;   spirocycle;   spirocycles;   spirocyclic compound;   spirocyclic compounds;   spirofused compounds


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eplerenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP Eplerenone inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein] CTD PMID:24512358 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
ivermectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCND1 cyclin D1 decreases expression EXP Ivermectin results in decreased expression of CCND1 mRNA CTD PMID:31400776 NCBI chr 2:3,621,242...3,633,380
Ensembl chr 2:3,621,246...3,633,296
JBrowse link
G CCNE1 cyclin E1 decreases expression EXP Ivermectin results in decreased expression of CCNE1 mRNA CTD PMID:31400776 NCBI chr 6:39,919,541...39,933,224
Ensembl chr 6:39,919,624...39,933,366
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ivermectin results in decreased phosphorylation of MAPK1 protein]; U 0126 promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK1 protein] CTD PMID:31400776 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ivermectin results in decreased phosphorylation of MAPK3 protein]; U 0126 promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK3 protein] CTD PMID:31400776 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP pyrazolanthrone promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK8 protein]; U 0126 promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK8 protein] CTD PMID:31400776 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP pyrazolanthrone promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK9 protein]; U 0126 promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK9 protein] CTD PMID:31400776 NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,369...78,399,105
JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP Ivermectin results in decreased expression of PCNA mRNA; Ivermectin results in decreased expression of PCNA protein CTD PMID:31400776 NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,125,814...14,185,276
JBrowse link
G RPS6 ribosomal protein S6 multiple interactions EXP Wortmannin promotes the reaction [Ivermectin results in decreased phosphorylation of RPS6 protein] CTD PMID:31400776 NCBI chr 1:203,444,360...203,447,643
Ensembl chr 1:203,444,450...203,451,468
JBrowse link
G RPS6KA1 ribosomal protein S6 kinase A1 multiple interactions EXP pyrazolanthrone inhibits the reaction [Ivermectin results in decreased phosphorylation of RPS6KA1 protein]; U 0126 promotes the reaction [Ivermectin results in decreased phosphorylation of RPS6KA1 protein] CTD PMID:31400776 NCBI chr 6:83,905,124...83,947,189
Ensembl chr 6:83,905,076...83,950,984
JBrowse link
troleandomycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A29 cytochrome P450 family 3 subfamily A member 29 multiple interactions EXP Troleandomycin inhibits the reaction [CYP3A29 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Troleandomycin inhibits the reaction [CYP3A29 protein results in increased hydroxylation of Testosterone]; Troleandomycin inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine] CTD PMID:20863320 NCBI chr 3:6,738,502...6,778,121 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 880
    chemical entity 880
      molecular entity 878
        polyatomic entity 843
          molecule 742
            cyclic compound 651
              polycyclic compound 327
                spiro compound 11
                  (+)-aplysinillin 0
                  (-)-spiroviolene 0
                  (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate 0
                  (4R,7R)-7-isopropenyl-4-methyl-1-oxaspiro[2.5]octane 0
                  (7R)-7-isopropenyl-4-methyl-1-oxaspiro[2.5]oct-4-ene 0
                  15-hydroxysolavetivone 0
                  5',7'-dimethylspiro[cyclohexane-1,3'-pyrimido[5,4-c][1,2,5]oxadiazine]-6',8'-dione 0
                  6-isopropyl-1-oxaspiro[2.5]octane 0
                  JP-8g 0
                  ainsliadimer A 0
                  amataine 0
                  azaspiro compound + 0
                  citrinalin B 0
                  crambescidin 401 0
                  crambescidin 800 0
                  crambescidin 826 0
                  ma'ilione 0
                  maremycin G 0
                  oxaspiro compound + 11
                  premnaspirodiene 0
                  rhizathalene A 0
                  solavetivol 0
                  solavetivone + 0
                  spirolaurenone 0
                  vetispirane + 0
                  viridicatumtoxin 0
                  vobtusine 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 880
    subatomic particle 865
      composite particle 865
        hadron 865
          baryon 865
            nucleon 865
              atomic nucleus 865
                atom 865
                  group 843
                    polyatomic entity 843
                      molecule 742
                        cyclic compound 651
                          polycyclic compound 327
                            spiro compound 11
                              (+)-aplysinillin 0
                              (-)-spiroviolene 0
                              (1S,3R,6R,8R,9R,11R,14S,15S,19R,20R)-8-ethyl-9,15-dihydroxy-3,4,6,20-tetramethyl-21,23-dioxo-24-azapentacyclo[20.2.1.0(1,6).0(11,20).0(14,19)]pentacosa-4,12,22(25)-trien-25-olate 0
                              (4R,7R)-7-isopropenyl-4-methyl-1-oxaspiro[2.5]octane 0
                              (7R)-7-isopropenyl-4-methyl-1-oxaspiro[2.5]oct-4-ene 0
                              15-hydroxysolavetivone 0
                              5',7'-dimethylspiro[cyclohexane-1,3'-pyrimido[5,4-c][1,2,5]oxadiazine]-6',8'-dione 0
                              6-isopropyl-1-oxaspiro[2.5]octane 0
                              JP-8g 0
                              ainsliadimer A 0
                              amataine 0
                              azaspiro compound + 0
                              citrinalin B 0
                              crambescidin 401 0
                              crambescidin 800 0
                              crambescidin 826 0
                              ma'ilione 0
                              maremycin G 0
                              oxaspiro compound + 11
                              premnaspirodiene 0
                              rhizathalene A 0
                              solavetivol 0
                              solavetivone + 0
                              spirolaurenone 0
                              vetispirane + 0
                              viridicatumtoxin 0
                              vobtusine 0
paths to the root