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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:carbocyclic compound
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Accession:CHEBI:33598 term browser browse the term
Definition:A homocyclic compound in which all of the ring members are carbon atoms.
Synonyms:exact_synonym: carbocyclic compounds
 related_synonym: carbocycle


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(-)-epigallocatechin 3-gallate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl affects the localization of and results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [[alpha-naphthoflavone co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [alpha-naphthoflavone results in increased activity of AHR protein] CTD PMID:12970578, PMID:22521609 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions
decreases expression
EXP epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 protein]; epigallocatechin gallate inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; HMOX1 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]]
epigallocatechin gallate results in decreased expression of CCL2 mRNA
CTD PMID:20580034, PMID:22521609, PMID:23380242 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CYP1A1 cytochrome P450 1A1 multiple interactions
decreases activity
decreases expression
EXP epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
epigallocatechin gallate results in decreased activity of CYP1A1 protein
epigallocatechin gallate results in decreased expression of CYP1A1 mRNA
CTD PMID:12970578, PMID:22521609 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,780,105...58,809,755
JBrowse link
G GSTO1 glutathione S-transferase omega 1 multiple interactions
increases expression
EXP [epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of GSTO1 mRNA; NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of GSTO1 mRNA] CTD PMID:22521609 NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions EXP HMOX1 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] CTD PMID:20580034
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of GSTO1 mRNA]; NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of NQO1 mRNA] CTD PMID:22521609 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
EXP epigallocatechin gallate results in increased expression of NQO1 mRNA
[epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of NQO1 mRNA; NFE2L2 protein affects the reaction [epigallocatechin gallate results in increased expression of NQO1 mRNA]
CTD PMID:22521609 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,769...17,302,590
JBrowse link
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions EXP epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Penicillins]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; HMOX1 protein promotes the reaction [epigallocatechin gallate inhibits the reaction [TNF protein results in increased expression of CCL2 protein]] CTD PMID:20580034 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
EXP epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein]; epigallocatechin gallate inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]
epigallocatechin gallate results in decreased expression of VCAM1 mRNA
CTD PMID:22521609, PMID:23380242 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link
(S)-colchicine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AMBP alpha-1-microglobulin/bikunin precursor decreases uptake EXP Colchicine results in decreased uptake of AMBP protein CTD PMID:9019736 NCBI chr 1:254,683,885...254,703,220
Ensembl chr 1:254,683,885...254,703,225
JBrowse link
1-chloro-2,4-dinitrobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G LOC100739163 glutathione S-transferase P-like affects metabolic processing EXP GSTP1 protein affects the metabolism of Dinitrochlorobenzene CTD PMID:14573868 NCBI chr 2:4,978,761...4,982,233 JBrowse link
16,16-dimethylprostaglandin E2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 multiple interactions
increases expression
EXP 16,16-Dimethylprostaglandin E2 inhibits the reaction [Ibuprofen results in decreased expression of NOS3 mRNA]
16,16-Dimethylprostaglandin E2 results in increased expression of NOS3 mRNA
CTD PMID:10525081 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
17beta-estradiol 3-benzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FGF7 fibroblast growth factor 7 affects expression EXP estradiol 3-benzoate affects the expression of FGF7 mRNA CTD PMID:15976484 NCBI chr 1:122,215,878...122,278,705
Ensembl chr 1:122,215,878...122,542,224
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 decreases expression
multiple interactions
EXP estradiol 3-benzoate results in decreased expression of FGFR2 mRNA alternative form
[Progesterone co-treated with estradiol 3-benzoate] results in decreased expression of FGFR2 mRNA alternative form
CTD PMID:15976484 NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,710...131,579,703
JBrowse link
2,2',4,4',5,5'-hexachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 decreases activity EXP 2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CYP11A1 protein CTD PMID:16151981 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP19A2 cytochrome P450 19A2 multiple interactions
decreases activity
EXP [2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Testosterone] affects the activity of CYP19A1 protein
2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CYP19A1 protein
CTD PMID:16151981 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 multiple interactions
decreases activity
EXP [2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Androstenedione] results in increased activity of HSD17B1 protein
2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of HSD17B1 protein
CTD PMID:16151981 NCBI chr12:20,269,468...20,271,349
Ensembl chr12:20,269,056...20,279,569
JBrowse link
2,3-dimethoxynaphthalene-1,4-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions EXP 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [TNF protein results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TPO thyroid peroxidase decreases activity EXP 2,3-dimethoxy-1,4-naphthoquinone results in decreased activity of TPO protein CTD PMID:11815678 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,408,943
JBrowse link
3,3',4,4',5-pentachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor increases expression
multiple interactions
increases activity
EXP 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AHR protein
epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of AHR protein]
CTD PMID:16552988, PMID:22521609 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943
JBrowse link
G CAV1 caveolin 1 multiple interactions EXP CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein]; CAV1 mutant form promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NQO1 mRNA] CTD PMID:19265715, PMID:20406653, PMID:24709675 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 increases expression
multiple interactions
EXP 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 protein
CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 protein]; NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]
CTD PMID:19265715, PMID:22521609 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CTSB cathepsin B decreases expression EXP 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of CTSB mRNA CTD PMID:16291828 NCBI chr14:15,014,139...15,035,081
Ensembl chr14:15,011,711...15,034,737
JBrowse link
G CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 decreases activity EXP 3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of CYP11A1 protein CTD PMID:16151981 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP19A2 cytochrome P450 19A2 increases activity
multiple interactions
EXP 3,4,5,3',4'-pentachlorobiphenyl results in increased activity of CYP19A1 protein
[3,4,5,3',4'-pentachlorobiphenyl co-treated with Testosterone] results in increased activity of CYP19A1 protein
CTD PMID:16151981 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G CYP1A1 cytochrome P450 1A1 multiple interactions
increases expression
EXP epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein]; NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; Quercetin inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein]
3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 protein
CTD PMID:16291828, PMID:19608276, PMID:22521609 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,780,105...58,809,755
JBrowse link
G GSTO1 glutathione S-transferase omega 1 multiple interactions EXP [epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of GSTO1 mRNA CTD PMID:22521609 NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613
JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 decreases activity EXP 3,4,5,3',4'-pentachlorobiphenyl results in decreased activity of HSD17B1 protein CTD PMID:16151981 NCBI chr12:20,269,468...20,271,349
Ensembl chr12:20,269,056...20,279,569
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:20406653 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 3,4,5,3',4'-pentachlorobiphenyl results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:20406653 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 multiple interactions EXP NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA] CTD PMID:22521609 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 increases expression
multiple interactions
EXP 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NQO1 mRNA
[epigallocatechin gallate co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of NQO1 mRNA; CAV1 mutant form promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of NQO1 mRNA]
CTD PMID:22521609, PMID:24709675 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,769...17,302,590
JBrowse link
G SLC5A5 solute carrier family 5 member 5 decreases expression EXP 3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of SLC5A5 mRNA CTD PMID:16291828 NCBI chr 2:59,869,157...59,885,086
Ensembl chr 2:59,869,154...59,885,265
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; CAV1 mutant form inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein]; NFE2L2 protein affects the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA]
3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 mRNA; 3,4,5,3',4'-pentachlorobiphenyl results in increased expression of VCAM1 protein
CTD PMID:20406653, PMID:22521609, PMID:24709675 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link
3,3',4,4'-tetrachlorobiphenyl term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP 3,4,3',4'-tetrachlorobiphenyl affects the localization of and results in increased activity of AHR protein; [alpha-naphthoflavone co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased activity of AHR protein; epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl affects the localization of and results in increased activity of AHR protein]; epigallocatechin gallate inhibits the reaction [[alpha-naphthoflavone co-treated with 3,4,3',4'-tetrachlorobiphenyl] results in increased activity of AHR protein]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl affects the localization of and results in increased activity of AHR protein] CTD PMID:12970578 NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943
JBrowse link
G CAV1 caveolin 1 multiple interactions EXP 3,4,3',4'-tetrachlorobiphenyl results in increased expression of and results in increased phosphorylation of CAV1 protein; CAV1 mutant form inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 protein]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of and results in increased phosphorylation of CAV1 protein] CTD PMID:19608276, PMID:20406653 NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 increases secretion
increases expression
multiple interactions
EXP 3,4,3',4'-tetrachlorobiphenyl results in increased secretion of CCL2 protein
3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA
[2,2'-azobis(2-amidinopropane) results in increased oxidation of Docosahexaenoic Acids] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; [2,2'-azobis(2-amidinopropane) results in increased oxidation of Docosahexaenoic Acids] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 protein]; [2,2'-azobis(2-amidinopropane) results in increased oxidation of Eicosapentaenoic Acid] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; [2,2'-azobis(2-amidinopropane) results in increased oxidation of Eicosapentaenoic Acid] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 protein]; Acetylcysteine inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; sodium borohydride inhibits the reaction [[2,2'-azobis(2-amidinopropane) results in increased oxidation of Docosahexaenoic Acids] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]]; sulforafan inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; Tretinoin promotes the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 protein]
CTD PMID:19265715, PMID:21130106 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G CYP1A1 cytochrome P450 1A1 increases activity
increases expression
multiple interactions
EXP 3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein
3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA; 3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 protein
alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]; epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein]; epigallocatechin gallate inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of CYP1A1 protein]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 protein]
CTD PMID:12970578, PMID:19608276 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,780,105...58,809,755
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased phosphorylation of MAPK1 protein] CTD PMID:20406653 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased phosphorylation of MAPK3 protein] CTD PMID:20406653 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit increases activity
multiple interactions
EXP 3,4,3',4'-tetrachlorobiphenyl results in increased activity of RELA protein
[2,2'-azobis(2-amidinopropane) results in increased oxidation of Docosahexaenoic Acids] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased activity of RELA protein]
CTD PMID:21130106 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G SELE selectin E increases expression
multiple interactions
EXP 3,4,3',4'-tetrachlorobiphenyl results in increased expression of SELE mRNA
Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of SELE mRNA]
CTD PMID:19608276 NCBI chr 4:81,289,061...81,299,657 JBrowse link
G SELP selectin P multiple interactions
increases expression
EXP Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of SELP mRNA] CTD PMID:19608276 NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,406,203
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions
increases expression
EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 mRNA]; CAV1 mutant form inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 protein]; Quercetin inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 mRNA]
3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 mRNA; 3,4,3',4'-tetrachlorobiphenyl results in increased expression of VCAM1 protein
CTD PMID:19608276, PMID:20406653 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link
3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5AP arachidonate 5-lipoxygenase activating protein multiple interactions EXP MK-886 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein] CTD PMID:21658425 NCBI chr11:7,371,328...7,438,111
Ensembl chr11:7,411,644...7,438,108
JBrowse link
G CASP3 caspase 3 multiple interactions EXP MK-886 inhibits the reaction [aristolochic acid I results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:21658425 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC4A2 solute carrier family 4 member 2 multiple interactions EXP 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid promotes the reaction [SLC4A2 protein binds to SLC4A2 protein] CTD PMID:10387099 NCBI chr18:6,149,459...6,166,622
Ensembl chr18:6,149,458...6,165,212
JBrowse link
7,12-dimethyltetraphene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 1A1 multiple interactions EXP 7-ketocholesterol inhibits the reaction [[Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein]; [Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein CTD PMID:11042205 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,780,105...58,809,755
JBrowse link
acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Aspirin inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein] CTD PMID:20665602 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G PLA2G1B phospholipase A2 group IB multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,444...40,322,319
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Aspirin promotes the reaction [PLA2G1B protein results in increased expression of PTGS2 mRNA] CTD PMID:10706128 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
acifluorfen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPOX protoporphyrinogen oxidase decreases activity EXP acifluorfen results in decreased activity of PPOX protein CTD PMID:7697001 NCBI chr 4:89,277,984...89,288,946
Ensembl chr 4:89,277,117...89,288,902
JBrowse link
alachlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C49 cytochrome P450 2C49 decreases response to substance EXP CYP2C49 protein results in decreased susceptibility to alachlor CTD PMID:16315095 NCBI chr14:106,571,803...106,612,082 JBrowse link
aminoglutethimide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GHRL ghrelin and obestatin prepropeptide multiple interactions EXP Aminoglutethimide promotes the reaction [GHRL protein results in decreased secretion of Progesterone] CTD PMID:22341706 NCBI chr13:66,442,106...66,453,576
Ensembl chr13:66,316,436...66,452,917
JBrowse link
arotinoid acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FABP4 fatty acid binding protein 4, adipocyte decreases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of FABP4 mRNA CTD PMID:15583048 NCBI chr 4:55,096,400...55,101,209
Ensembl chr 4:55,096,404...55,101,897
JBrowse link
G GPD1 glycerol-3-phosphate dehydrogenase 1 decreases activity EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased activity of GPD1 protein CTD PMID:15583048 NCBI chr 5:16,008,179...16,021,676
Ensembl chr 5:16,007,448...16,017,825
JBrowse link
G NR2F1 nuclear receptor subfamily 2 group F member 1 increases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased expression of NR2F1 mRNA CTD PMID:15583048 NCBI chr 2:100,447,661...100,457,510
Ensembl chr 2:100,447,847...100,457,904
JBrowse link
G PPARG peroxisome proliferator activated receptor gamma decreases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of PPARG mRNA CTD PMID:15583048 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,655...68,433,947
JBrowse link
G RXRA retinoid X receptor alpha decreases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of RXRA mRNA CTD PMID:15583048 NCBI chr 1:273,698,842...273,797,622
Ensembl chr 1:273,705,503...273,797,622
JBrowse link
G SREBP-1 sterol regulatory element binding protein 1 decreases expression EXP 4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in decreased expression of SREBP-1 mRNA CTD PMID:15583048
aspartame term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions
increases hydrolysis
EXP 1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
benzo[a]pyrene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions EXP Benzo(a)pyrene inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein]; Benzo(a)pyrene inhibits the reaction [ADIPOQ protein results in increased secretion of Estradiol]; Benzo(a)pyrene results in decreased expression of and results in decreased secretion of ADIPOQ protein CTD PMID:28284726 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,684...124,646,648
JBrowse link
G ADIPOR1 adiponectin receptor 1 decreases expression EXP Benzo(a)pyrene results in decreased expression of ADIPOR1 protein CTD PMID:28284726 NCBI chr10:24,907,491...24,923,540 JBrowse link
G ADIPOR2 adiponectin receptor 2 decreases expression EXP Benzo(a)pyrene results in decreased expression of ADIPOR2 protein CTD PMID:28284726 NCBI chr 5:68,755,789...68,807,247
Ensembl chr 5:68,755,811...68,807,235
JBrowse link
G CYP19A2 cytochrome P450 19A2 multiple interactions EXP Benzo(a)pyrene inhibits the reaction [ADIPOQ protein results in increased expression of CYP19A1 protein] CTD PMID:28284726 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G CYP1A1 cytochrome P450 1A1 increases expression
multiple interactions
EXP Benzo(a)pyrene results in increased expression of CYP1A1 protein
7-ketocholesterol inhibits the reaction [[Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein]; [Benzo(a)pyrene co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of CYP1A1 protein
CTD PMID:11042205, PMID:18636242 NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,780,105...58,809,755
JBrowse link
bezafibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOA1 apolipoprotein A1 increases expression
increases secretion
EXP Bezafibrate results in increased expression of APOA1 mRNA
Bezafibrate results in increased secretion of APOA1 protein
CTD PMID:16530456 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,393...44,218,978
JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Bezafibrate inhibits the reaction [Cisplatin affects the localization of BAX protein] CTD PMID:16316343 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BCL2 BCL2 apoptosis regulator increases expression EXP Bezafibrate results in increased expression of BCL2 CTD PMID:16316343 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G CASP3 caspase 3 multiple interactions EXP Bezafibrate inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein] CTD PMID:16316343 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP Bezafibrate inhibits the reaction [Cisplatin affects the localization of CYCS protein] CTD PMID:16316343 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866
JBrowse link
G LIPG lipase G, endothelial type decreases expression EXP Bezafibrate results in decreased expression of LIPG mRNA; Bezafibrate results in decreased expression of LIPG protein CTD PMID:15953354 NCBI chr 1:99,081,940...99,110,671
Ensembl chr 1:99,081,938...99,110,876
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha multiple interactions EXP Bezafibrate inhibits the reaction [[Cisplatin results in decreased activity of PPARA protein] which results in increased abundance of Fatty Acids, Nonesterified]; Bezafibrate inhibits the reaction [Cisplatin results in decreased activity of PPARA protein] CTD PMID:16316343 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,708...3,366,361
JBrowse link
G SCARB1 scavenger receptor class B member 1 affects localization
increases expression
EXP Bezafibrate affects the localization of SCARB1 protein
Bezafibrate results in increased expression of SCARB1 mRNA
CTD PMID:16530456 NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,565
JBrowse link
capsazepine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions EXP capsazepine inhibits the reaction [Sodium affects the reaction [TRPV1 protein results in increased abundance of Calcium]] CTD PMID:18230619 NCBI chr12:49,676,536...49,709,634
Ensembl chr12:49,677,291...49,701,325
JBrowse link
carvacrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RYR1 ryanodine receptor 1 increases activity EXP carvacrol results in increased activity of RYR1 protein CTD PMID:17641978 NCBI chr 6:47,339,759...47,458,457 JBrowse link
chlorogenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COMT catechol-O-methyltransferase decreases activity EXP Chlorogenic Acid results in decreased activity of COMT protein CTD PMID:27270453 NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,133...51,403,998
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of CXCL8 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL8 mRNA] CTD PMID:27861533 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G IL6 interleukin 6 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:27861533 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA] CTD PMID:27861533 NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,013...127,858,884
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Chlorogenic Acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA] CTD PMID:27861533 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
chlorotoluron term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B22 cytochrome P450 2B22 decreases response to substance EXP CYP2B22 protein results in decreased susceptibility to chlortoluron CTD PMID:16315095 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,413
JBrowse link
G CYP2C49 cytochrome P450 2C49 decreases response to substance EXP CYP2C49 protein results in decreased susceptibility to chlortoluron CTD PMID:16315095 NCBI chr14:106,571,803...106,612,082 JBrowse link
chlortetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions
increases uptake
EXP Chlortetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline] CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link
cinaciguat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 multiple interactions EXP BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein] CTD PMID:19466990 NCBI chr 8:44,448,758...44,520,737
Ensembl chr 8:44,449,232...44,518,135
JBrowse link
G GUCY1B1 guanylate cyclase 1 soluble subunit beta 1 multiple interactions EXP BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein] CTD PMID:19466990 NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,704
JBrowse link
ciprofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TNF tumor necrosis factor multiple interactions EXP [ciprofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein] CTD PMID:15226458 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
clofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO1 aconitase 1 increases expression EXP Clofibrate results in increased expression of ACO1 mRNA CTD PMID:17363680 NCBI chr10:33,937,833...34,001,895
Ensembl chr10:33,937,833...34,001,900
JBrowse link
G ACOX1 acyl-CoA oxidase 1 increases expression EXP Clofibrate results in increased expression of ACOX1 mRNA CTD PMID:16896063, PMID:17437637 NCBI chr12:5,450,913...5,479,550
Ensembl chr12:5,428,360...5,479,544
JBrowse link
G AGT angiotensinogen multiple interactions EXP Clofibrate inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein] CTD PMID:17105827 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G ALB albumin decreases expression EXP Clofibrate results in decreased expression of ALB mRNA CTD PMID:16896063 NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,718,304
JBrowse link
G BAX BCL2 associated X, apoptosis regulator increases expression EXP Clofibrate results in increased expression of BAX mRNA CTD PMID:17437637 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,187,260...54,228,144
JBrowse link
G BCL2L1 BCL2 like 1 decreases expression EXP Clofibrate results in decreased expression of BCL2L1 mRNA CTD PMID:17437637 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,141...35,415,359
JBrowse link
G CAT catalase increases expression EXP Clofibrate results in increased expression of CAT mRNA CTD PMID:17437637 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A increases expression EXP Clofibrate results in increased expression of CPT1A mRNA CTD PMID:16896063, PMID:17363680 NCBI chr 2:4,250,642...4,293,914
Ensembl chr 2:4,233,099...4,293,984
JBrowse link
G CTSB cathepsin B increases expression EXP Clofibrate results in increased expression of CTSB mRNA CTD PMID:16896063 NCBI chr14:15,014,139...15,035,081
Ensembl chr14:15,011,711...15,034,737
JBrowse link
G DIO2 iodothyronine deiodinase 2 decreases expression EXP Clofibrate results in decreased expression of DIO2 mRNA CTD PMID:16896063 NCBI chr 7:103,096,414...103,110,749
Ensembl chr 7:103,096,425...103,323,258
JBrowse link
G EDN1 endothelin 1 decreases expression
multiple interactions
EXP Clofibrate results in decreased expression of EDN1 protein
Clofibrate inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]; Clofibrate inhibits the reaction [KNG1 protein modified form results in increased expression of EDN1 protein]; Clofibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EDN1 protein]; Nitric Oxide deficiency inhibits the reaction [Clofibrate results in decreased expression of EDN1 protein]
CTD PMID:17105827 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G FABP1 fatty acid binding protein 1 increases expression EXP Clofibrate results in increased expression of FABP1 mRNA CTD PMID:17363680 NCBI chr 3:57,850,511...57,854,966
Ensembl chr 3:57,850,499...57,854,964
JBrowse link
G GPX1 glutathione peroxidase 1 decreases expression EXP Clofibrate results in decreased expression of GPX1 mRNA CTD PMID:17437637 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP Clofibrate results in increased expression of JUN mRNA CTD PMID:17437637 NCBI chr 6:153,686,425...153,687,635 JBrowse link
G KNG1 kininogen 1 multiple interactions EXP Clofibrate inhibits the reaction [KNG1 protein modified form results in increased expression of EDN1 protein] CTD PMID:17105827 NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,277...124,557,376
JBrowse link
G LOC110260333 hydroxymethylglutaryl-CoA synthase, mitochondrial-like increases expression EXP Clofibrate results in increased expression of HMGCS2 mRNA CTD PMID:17363680 NCBI chr 4:101,385,486...101,404,273
Ensembl chr 4:101,385,512...101,443,405
JBrowse link
G MYC MYC proto-oncogene, bHLH transcription factor increases expression EXP Clofibrate results in increased expression of MYC mRNA CTD PMID:17437637 NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,119...12,461,078
JBrowse link
G NOS3 nitric oxide synthase 3 increases expression
multiple interactions
EXP Clofibrate results in increased expression of NOS3 protein
calphostin C inhibits the reaction [Clofibrate results in increased expression of NOS3 protein]
CTD PMID:17105827 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
G PPARA peroxisome proliferator activated receptor alpha increases expression
multiple interactions
EXP Clofibrate results in increased expression of PPARA; Clofibrate results in increased expression of PPARA protein
calphostin C inhibits the reaction [Clofibrate results in increased expression of PPARA protein]; calphostin C inhibits the reaction [Clofibrate results in increased expression of PPARA]; Tetradecanoylphorbol Acetate inhibits the reaction [Clofibrate results in increased expression of PPARA]
CTD PMID:17105827, PMID:20568414 NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,708...3,366,361
JBrowse link
G SCD stearoyl-CoA desaturase increases expression EXP Clofibrate results in increased expression of SCD mRNA CTD PMID:17363680 NCBI chr14:111,461,560...111,478,033
Ensembl chr14:111,461,560...111,478,031
JBrowse link
G SLC5A5 solute carrier family 5 member 5 increases expression EXP Clofibrate results in increased expression of SLC5A5 mRNA CTD PMID:16896063 NCBI chr 2:59,869,157...59,885,086
Ensembl chr 2:59,869,154...59,885,265
JBrowse link
G SOD1 superoxide dismutase 1 increases expression EXP Clofibrate results in increased expression of SOD1 mRNA CTD PMID:17437637 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G THRA thyroid hormone receptor alpha decreases expression EXP Clofibrate results in decreased expression of THRA mRNA CTD PMID:16896063 NCBI chr12:22,270,506...22,296,684
Ensembl chr12:22,270,062...22,296,618
JBrowse link
G TNF tumor necrosis factor decreases expression EXP Clofibrate results in decreased expression of TNF mRNA CTD PMID:17437637 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TPO thyroid peroxidase increases expression EXP Clofibrate results in increased expression of TPO mRNA CTD PMID:16896063 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,408,943
JBrowse link
G TSHR thyroid stimulating hormone receptor increases expression EXP Clofibrate results in increased expression of TSHR mRNA CTD PMID:16896063 NCBI chr 7:103,768,260...103,925,777
Ensembl chr 7:103,768,296...103,925,922
JBrowse link
G TTR transthyretin decreases expression EXP Clofibrate results in decreased expression of TTR mRNA CTD PMID:16896063 NCBI chr 6:115,496,338...115,503,974
Ensembl chr 6:115,496,193...115,503,977
JBrowse link
cocaine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases expression
multiple interactions
EXP Cocaine results in increased expression of EDN1 protein
1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]; Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]
CTD PMID:9714087 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
crizotinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NTRK1 neurotrophic receptor tyrosine kinase 1 decreases activity EXP Crizotinib results in decreased activity of NTRK1 protein CTD PMID:21812414 NCBI chr 4:93,219,509...93,237,944
Ensembl chr 4:93,219,516...93,237,930
JBrowse link
G NTRK2 neurotrophic receptor tyrosine kinase 2 decreases activity EXP Crizotinib results in decreased activity of NTRK2 protein CTD PMID:21812414 NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,379...30,429,882
JBrowse link
curcumin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACO2 aconitase 2 multiple interactions EXP Curcumin inhibits the reaction [maleic acid results in decreased activity of ACO2 protein] CTD PMID:25119790 NCBI chr 5:7,014,383...7,071,023
Ensembl chr 5:7,002,124...7,070,999
JBrowse link
DDE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 decreases expression
multiple interactions
EXP Dichlorodiphenyl Dichloroethylene results in decreased expression of CYP11A1 mRNA
Dichlorodiphenyl Dichloroethylene inhibits the reaction [Cholera Toxin results in increased expression of CYP11A1 mRNA]
CTD PMID:11226075 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP19A2 cytochrome P450 19A2 increases activity EXP Dichlorodiphenyl Dichloroethylene results in increased activity of CYP19A1 protein CTD PMID:18195494 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
doxorubicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA1L heat shock protein family A (Hsp70) member 1 like increases expression EXP Doxorubicin results in increased expression of HSPA1A protein CTD PMID:15810080 NCBI chr 7:23,909,960...23,938,678
Ensembl chr 7:23,909,960...23,921,723
JBrowse link
G MMP1 matrix metallopeptidase 1 increases activity
increases expression
EXP Doxorubicin results in increased activity of MMP1 protein
Doxorubicin results in increased expression of MMP1 mRNA
CTD PMID:19782292 NCBI chr 9:33,411,738...33,420,205
Ensembl chr 9:33,411,065...33,454,000
JBrowse link
G MMP14 matrix metallopeptidase 14 increases expression
increases activity
EXP Doxorubicin results in increased expression of MMP14 mRNA
Doxorubicin results in increased activity of MMP14 protein
CTD PMID:19782292 NCBI chr 7:76,174,502...76,185,931
Ensembl chr 7:76,174,500...76,185,923
JBrowse link
G MMP2 matrix metallopeptidase 2 increases expression
increases activity
EXP Doxorubicin results in increased expression of MMP2 mRNA
Doxorubicin results in increased activity of MMP2 protein
CTD PMID:19782292 NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,594...30,086,982
JBrowse link
G MMP9 matrix metallopeptidase 9 increases expression
increases activity
EXP Doxorubicin results in increased expression of MMP9 mRNA
Doxorubicin results in increased activity of MMP9 protein
CTD PMID:19782292 NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,175,056...48,188,264
JBrowse link
G TNF tumor necrosis factor decreases expression EXP Doxorubicin results in decreased expression of TNF mRNA CTD PMID:15810080 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
doxycycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 increases uptake
multiple interactions
EXP SLCO1A2 protein results in increased uptake of Doxycycline
Doxycycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Doxycycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]
CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link
fenofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA1 ATP binding cassette subfamily A member 1 affects localization EXP Fenofibrate affects the localization of ABCA1 protein CTD PMID:16530456 NCBI chr 1:246,144,277...246,278,492
Ensembl chr 1:246,144,277...246,278,492
JBrowse link
G APOA1 apolipoprotein A1 increases secretion
decreases expression
multiple interactions
EXP Fenofibrate results in increased secretion of APOA1 protein
Fenofibrate results in decreased expression of APOA1 mRNA
Fenofibrate inhibits the reaction [APOA1 protein results in increased transport of Cholesterol]; Fenofibrate promotes the reaction [APOA1 protein results in increased transport of Cholesterol]
CTD PMID:16530456 NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,393...44,218,978
JBrowse link
G SCARB1 scavenger receptor class B member 1 affects localization EXP Fenofibrate affects the localization of SCARB1 protein CTD PMID:16530456 NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,565
JBrowse link
G TNF tumor necrosis factor multiple interactions EXP [Fenofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein] CTD PMID:15226458 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
flutamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 affects expression EXP Flutamide affects the expression of GJA1 mRNA CTD PMID:20961722 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,515...41,002,137
JBrowse link
gamma-hexachlorocyclohexane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase decreases activity EXP Hexachlorocyclohexane results in decreased activity of CAT protein CTD PMID:16838206 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
gefitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FES FES proto-oncogene, tyrosine kinase multiple interactions
decreases phosphorylation
EXP Gefitinib inhibits the reaction [FGF2 protein results in increased phosphorylation of FES protein]; Gefitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of FES protein]
Gefitinib results in decreased phosphorylation of FES protein
CTD PMID:19885553 NCBI chr 7:53,472,947...53,485,084
Ensembl chr 7:53,472,946...53,485,082
JBrowse link
G FGF2 fibroblast growth factor 2 multiple interactions EXP Gefitinib inhibits the reaction [FGF2 protein results in increased phosphorylation of FES protein] CTD PMID:19885553 NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,878...101,343,916
JBrowse link
G VEGFA vascular endothelial growth factor A multiple interactions EXP Gefitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of FES protein] CTD PMID:19885553 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,038
JBrowse link
glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 multiple interactions EXP Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein] CTD PMID:18840580 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
haloperidol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 multiple interactions EXP Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein] CTD PMID:9714087 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
hexachlorobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADIPOQ adiponectin, C1Q and collagen domain containing multiple interactions EXP Hexachlorobenzene inhibits the reaction [ADIPOQ protein results in increased secretion of Estradiol]; Hexachlorobenzene results in decreased expression of and results in decreased secretion of ADIPOQ protein CTD PMID:28284726 NCBI chr13:124,633,906...124,646,237
Ensembl chr13:124,633,684...124,646,648
JBrowse link
G ADIPOR1 adiponectin receptor 1 decreases expression EXP Hexachlorobenzene results in decreased expression of ADIPOR1 protein CTD PMID:28284726 NCBI chr10:24,907,491...24,923,540 JBrowse link
G ADIPOR2 adiponectin receptor 2 decreases expression EXP Hexachlorobenzene results in decreased expression of ADIPOR2 protein CTD PMID:28284726 NCBI chr 5:68,755,789...68,807,247
Ensembl chr 5:68,755,811...68,807,235
JBrowse link
G CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 increases expression EXP Hexachlorobenzene results in increased expression of CYP11A1 protein CTD PMID:21296658 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP17A1 cytochrome P450 17A1 decreases expression EXP Hexachlorobenzene results in decreased expression of CYP17A1 protein CTD PMID:21296658 NCBI chr14:113,805,616...113,820,445
Ensembl chr14:113,805,611...113,812,041
JBrowse link
G CYP19A2 cytochrome P450 19A2 decreases expression EXP Hexachlorobenzene results in decreased expression of CYP19A1 protein CTD PMID:21296658 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
G HSD17B1 hydroxysteroid 17-beta dehydrogenase 1 decreases expression EXP Hexachlorobenzene results in decreased expression of HSD17B1 protein CTD PMID:21296658 NCBI chr12:20,269,468...20,271,349
Ensembl chr12:20,269,056...20,279,569
JBrowse link
hydroxytyrosol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] CTD PMID:21798251 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein] CTD PMID:21798251 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
indometacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen affects activity EXP Indomethacin affects the activity of AGT protein CTD PMID:21127344 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP Indomethacin results in increased expression of DDIT3 mRNA CTD PMID:18799549 NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,441...22,791,134
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Indomethacin results in increased expression of HSPA5 mRNA CTD PMID:18799549 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
itraconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions EXP Itraconazole inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines] CTD PMID:21056966 NCBI chr 9:93,171,371...93,262,124 JBrowse link
ketoconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A29 cytochrome P450 3A29 multiple interactions EXP Ketoconazole inhibits the reaction [CYP3A29 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine] CTD PMID:20863320 NCBI chr 3:6,738,502...6,778,121 JBrowse link
lapatinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FSHB follicle stimulating hormone subunit beta decreases activity
multiple interactions
EXP Lapatinib results in decreased activity of FSHB protein
Lapatinib inhibits the reaction [FSHB protein results in increased abundance of Progesterone]
CTD PMID:23375200 NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274
JBrowse link
G LHB luteinizing hormone subunit beta decreases activity
multiple interactions
EXP Lapatinib results in decreased activity of LHB protein
Lapatinib inhibits the reaction [LHB protein results in increased abundance of Progesterone]
CTD PMID:23375200 NCBI chr 6:54,263,574...54,269,286 JBrowse link
losartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen affects activity EXP Losartan affects the activity of AGT protein CTD PMID:21127344 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
metolachlor term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B22 cytochrome P450 2B22 multiple interactions EXP CYP2B22 protein results in increased metabolism of and results in decreased susceptibility to metolachlor CTD PMID:16315095 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,413
JBrowse link
N,N-dimethylaniline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases metabolic processing EXP FMO1 protein results in increased metabolism of N,N-dimethylaniline CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,812,103...63,895,077
JBrowse link
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CREB1 cAMP responsive element binding protein 1 multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein] CTD PMID:17680988 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,697,408...110,771,755
JBrowse link
G IL6 interleukin 6 decreases expression
multiple interactions
EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of IL6 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein]
CTD PMID:24105867 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G PRKACB protein kinase cAMP-activated catalytic subunit beta multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein] CTD PMID:24105867 NCBI chr 6:129,520,397...129,636,207
Ensembl chr 6:129,519,962...129,635,517
JBrowse link
nimesulide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP nimesulide inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein] CTD PMID:20665602 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
norflurazon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C49 cytochrome P450 2C49 multiple interactions EXP CYP2C49 protein results in increased metabolism of and results in decreased susceptibility to norflurazone CTD PMID:16315095 NCBI chr14:106,571,803...106,612,082 JBrowse link
o-aminoacetophenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2A19 cytochrome P450 2A19 multiple interactions EXP 2-aminoacetophenone inhibits the reaction [[CYP2A19 protein results in increased hydroxylation of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin]; 2-aminoacetophenone inhibits the reaction [CYP2A19 protein results in increased hydroxylation of coumarin] CTD PMID:30599194 NCBI chr 6:49,056,579...49,064,111
Ensembl chr 6:49,056,578...49,064,107
JBrowse link
G CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 multiple interactions EXP 2-aminoacetophenone inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; 2-aminoacetophenone inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] CTD PMID:30599194 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,818
JBrowse link
ochratoxin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation EXP ochratoxin A results in decreased phosphorylation of AKT1 protein CTD PMID:30287338
G ANXA5 annexin A5 decreases expression EXP ochratoxin A results in decreased expression of ANXA5 mRNA CTD PMID:14994279 NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750
JBrowse link
G ATG5 autophagy related 5 multiple interactions
increases expression
EXP ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]
ochratoxin A results in increased expression of ATG5 protein
CTD PMID:28699257, PMID:30287338 NCBI chr 1:72,343,950...72,520,402
Ensembl chr 1:72,270,799...72,520,453
JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
affects expression
multiple interactions
EXP ochratoxin A results in decreased expression of BCL2 mRNA
ochratoxin A affects the expression of BCL2 mRNA
TLR4 protein affects the reaction [ochratoxin A affects the expression of BCL2 mRNA]
CTD PMID:28528741, PMID:29080797 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,288,544...158,518,879
JBrowse link
G BECN1 beclin 1 multiple interactions
increases expression
EXP BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]
ochratoxin A results in increased expression of BECN1 protein
CTD PMID:30287338 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373
JBrowse link
G BRCA1 BRCA1 DNA repair associated increases expression EXP ochratoxin A results in increased expression of BRCA1 protein CTD PMID:32454083 NCBI chr12:19,788,087...19,854,515
Ensembl chr12:19,786,020...19,855,570
JBrowse link
G CASP3 caspase 3 multiple interactions
increases cleavage
EXP 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein] CTD PMID:30287338 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CAT catalase decreases expression EXP ochratoxin A results in decreased expression of CAT protein CTD PMID:18547704 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CRYAB crystallin alpha B increases expression EXP ochratoxin A results in increased expression of CRYAB mRNA CTD PMID:14994279 NCBI chr 9:39,638,505...39,643,530
Ensembl chr 9:39,638,502...39,643,530
JBrowse link
G CYP2A19 cytochrome P450 2A19 decreases expression EXP ochratoxin A results in decreased expression of CYP2A6 mRNA CTD PMID:14994279 NCBI chr 6:49,056,579...49,064,111
Ensembl chr 6:49,056,578...49,064,107
JBrowse link
G DAD1 defender against cell death 1 decreases expression EXP ochratoxin A results in decreased expression of DAD1 mRNA CTD PMID:14994279 NCBI chr 7:76,432,040...76,457,403
Ensembl chr 7:76,432,029...76,457,192
JBrowse link
G DNMT1 DNA methyltransferase 1 increases expression
multiple interactions
EXP ochratoxin A results in increased expression of DNMT1 mRNA; ochratoxin A results in increased expression of DNMT1 protein
Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 protein]
CTD PMID:29080797, PMID:30923867 NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,564...69,029,919
JBrowse link
G DNMT3A DNA methyltransferase 3 alpha increases expression EXP ochratoxin A results in increased expression of DNMT3A mRNA CTD PMID:29080797, PMID:30923867 NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,609,139
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit decreases expression
multiple interactions
EXP ochratoxin A results in decreased expression of GCLC mRNA
ochratoxin A inhibits the reaction [sulforafan results in increased expression of GCLC mRNA]
CTD PMID:18547363 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
G GLMN glomulin, FKBP associated protein increases expression EXP ochratoxin A results in increased expression of GLMN mRNA CTD PMID:14994279 NCBI chr 4:124,773,957...124,813,336
Ensembl chr 4:124,773,979...124,813,337
JBrowse link
G HDAC1 histone deacetylase 1 multiple interactions
increases expression
EXP Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 mRNA]; Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 protein]
ochratoxin A results in increased expression of HDAC1 mRNA; ochratoxin A results in increased expression of HDAC1 protein
CTD PMID:29080797 NCBI chr 6:88,749,611...88,785,220
Ensembl chr 6:88,749,634...88,785,412
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression
decreases expression
EXP ochratoxin A results in increased expression of HSP90B1 mRNA
ochratoxin A results in decreased expression of HSP90B1 mRNA
CTD PMID:14994279 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP ochratoxin A results in increased expression of HSPA5 mRNA; ochratoxin A results in increased expression of HSPA5 protein CTD PMID:28699257 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 decreases expression EXP ochratoxin A results in decreased expression of HSPD1 mRNA CTD PMID:14994279 NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,527
JBrowse link
G ID2 inhibitor of DNA binding 2 decreases expression EXP ochratoxin A results in decreased expression of ID2 mRNA CTD PMID:14994279 NCBI chr 3:127,500,759...127,503,207
Ensembl chr 3:127,500,759...127,503,257
JBrowse link
G IGFBP2 insulin like growth factor binding protein 2 increases expression EXP ochratoxin A results in increased expression of IGFBP2 mRNA CTD PMID:14994279 NCBI chr15:118,822,092...118,850,985
Ensembl chr15:118,822,047...118,850,976
JBrowse link
G IL1A interleukin 1 alpha multiple interactions EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]] CTD PMID:28528741 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119
JBrowse link
G IL2 interleukin 2 decreases secretion EXP ochratoxin A results in decreased secretion of IL2 protein CTD PMID:28699257 NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609
JBrowse link
G IL4 interleukin 4 increases expression EXP ochratoxin A results in increased expression of IL4 mRNA CTD PMID:14994279 NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365
JBrowse link
G IL6 interleukin 6 increases expression
multiple interactions
EXP ochratoxin A results in increased expression of IL6 mRNA
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of IL6 mRNA]
CTD PMID:28710020 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,340...91,511,263
JBrowse link
G JAK2 Janus kinase 2 multiple interactions
increases phosphorylation
EXP Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of JAK2 protein] CTD PMID:30923867 NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,686...217,002,148
JBrowse link
G LOC100522201 histone H2AX multiple interactions
increases expression
EXP alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in increased expression of H2AX protein]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of H2AX protein]; STAT3 protein affects the reaction [ochratoxin A results in increased expression of H2AX protein] CTD PMID:30923867 NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
EXP ochratoxin A results in increased phosphorylation of MAPK1 protein
ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
CTD PMID:28528741, PMID:28699257 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions
increases phosphorylation
EXP ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
ochratoxin A results in increased phosphorylation of MAPK3 protein
CTD PMID:28528741, PMID:28699257 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MTOR mechanistic target of rapamycin kinase decreases phosphorylation EXP ochratoxin A results in decreased phosphorylation of MTOR protein CTD PMID:30287338 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888
JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor multiple interactions EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein] CTD PMID:28528741 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,964,071...22,983,109
JBrowse link
G NEIL1 nei like DNA glycosylase 1 decreases expression
multiple interactions
EXP ochratoxin A results in decreased expression of NEIL1 mRNA
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]
CTD PMID:30923867 NCBI chr 7:58,261,761...58,269,001
Ensembl chr 7:58,261,761...58,283,092
JBrowse link
G NEIL3 nei like DNA glycosylase 3 multiple interactions
decreases expression
EXP alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA] CTD PMID:30923867 NCBI chr15:39,416,073...39,632,313
Ensembl chr15:39,581,856...39,632,310
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 decreases activity
multiple interactions
decreases expression
EXP ochratoxin A results in decreased activity of NFE2L2 protein
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TP53 protein]; ochratoxin A inhibits the reaction [sulforafan affects the localization of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforafan results in increased activity of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforafan results in increased expression of NFE2L2 mRNA]
ochratoxin A results in decreased expression of NFE2L2 mRNA
CTD PMID:18547363, PMID:18547704, PMID:28710020 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G NPM1 nucleophosmin 1 increases expression EXP ochratoxin A results in increased expression of NPM1 mRNA CTD PMID:14994279 NCBI chr16:52,767,263...52,781,862
Ensembl chr16:52,765,296...52,781,740
JBrowse link
G OGG1 8-oxoguanine DNA glycosylase decreases expression
multiple interactions
EXP ochratoxin A results in decreased expression of OGG1 mRNA
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]
CTD PMID:30923867 NCBI chr13:66,038,669...66,045,478 JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage
increases expression
multiple interactions
EXP ochratoxin A results in increased cleavage of PARP1 protein
ochratoxin A results in increased expression of PARP1 protein
3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein]
CTD PMID:30287338, PMID:32454083 NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,159...14,241,197
JBrowse link
G PCK1 phosphoenolpyruvate carboxykinase 1 decreases expression EXP ochratoxin A results in decreased expression of PCK1 mRNA; ochratoxin A results in decreased expression of PCK1 protein CTD PMID:3753873 NCBI chr17:57,930,507...57,936,523
Ensembl chr17:57,930,432...57,938,896
JBrowse link
G PCNA proliferating cell nuclear antigen decreases expression EXP ochratoxin A results in decreased expression of PCNA protein CTD PMID:32454083 NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,125,814...14,185,276
JBrowse link
G PFDN5 prefoldin subunit 5 decreases expression EXP ochratoxin A results in decreased expression of PFDN5 mRNA CTD PMID:14994279 NCBI chr 5:18,512,637...18,516,928
Ensembl chr 5:18,512,719...18,525,877
JBrowse link
G PPIA peptidylprolyl isomerase A increases expression EXP ochratoxin A results in increased expression of PPIA mRNA CTD PMID:14994279 NCBI chr18:50,563,130...50,566,857 JBrowse link
G PRDX1 peroxiredoxin 1 decreases expression EXP ochratoxin A results in decreased expression of PRDX1 mRNA CTD PMID:14994279 NCBI chr 6:165,847,390...165,859,918
Ensembl chr 6:165,824,520...165,861,442
JBrowse link
G PTMA prothymosin alpha decreases expression EXP ochratoxin A results in decreased expression of PTMA mRNA CTD PMID:14994279 NCBI chr15:132,353,763...132,361,442
Ensembl chr15:132,355,655...132,361,435
JBrowse link
G RAD51 RAD51 recombinase increases expression EXP ochratoxin A results in increased expression of RAD51 protein CTD PMID:32454083 NCBI chr 1:130,592,414...130,640,326
Ensembl chr 1:130,586,647...130,640,136
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:28528741 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,471
JBrowse link
G RPA2 replication protein A2 increases expression EXP ochratoxin A results in increased expression of RPA2 protein CTD PMID:32454083 NCBI chr 6:85,032,604...85,045,899
Ensembl chr 6:85,031,578...85,045,916
JBrowse link
G RPS5 ribosomal protein S5 increases expression EXP ochratoxin A results in increased expression of RPS5 mRNA CTD PMID:14994279 NCBI chr 6:62,967,955...62,974,353
Ensembl chr 6:62,921,635...62,974,354
JBrowse link
G SOCS3 suppressor of cytokine signaling 3 increases expression
multiple interactions
EXP ochratoxin A results in increased expression of SOCS3 mRNA; ochratoxin A results in increased expression of SOCS3 protein
Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 mRNA]; Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 protein]
CTD PMID:30923867 NCBI chr12:3,643,832...3,647,015
Ensembl chr12:3,643,929...3,647,012
JBrowse link
G SOD1 superoxide dismutase 1 decreases activity EXP ochratoxin A results in decreased activity of SOD1 protein CTD PMID:18547704 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SQSTM1 sequestosome 1 multiple interactions
decreases expression
EXP Chloroquine inhibits the reaction [ochratoxin A results in decreased expression of SQSTM1 protein] CTD PMID:30287338 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,768...78,784,256
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions
increases phosphorylation
EXP Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in increased expression of H2AX protein] CTD PMID:30923867 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,993
JBrowse link
G SUMO1 small ubiquitin like modifier 1 decreases expression EXP ochratoxin A results in decreased expression of SUMO1 mRNA CTD PMID:14994279 NCBI chr15:105,820,237...105,850,099
Ensembl chr15:105,815,281...105,850,943
JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression
multiple interactions
EXP ochratoxin A results in increased expression of TGFB1 mRNA
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; sulforafan inhibits the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]
CTD PMID:28710020 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
G TIMP2 TIMP metallopeptidase inhibitor 2 increases expression EXP ochratoxin A results in increased expression of TIMP2 mRNA CTD PMID:14994279 NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,835
JBrowse link
G TJP1 tight junction protein 1 affects localization EXP ochratoxin A affects the localization of TJP1 protein CTD PMID:14994279 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,368...145,195,836
JBrowse link
G TLR4 toll like receptor 4 multiple interactions EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TLR4 protein affects the reaction [ochratoxin A affects the expression of BCL2 mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] CTD PMID:28528741 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,059,004
JBrowse link
G TNF tumor necrosis factor multiple interactions
increases secretion
EXP ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
ochratoxin A results in increased secretion of TNF protein
CTD PMID:28528741, PMID:28699257 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,636...23,703,655
JBrowse link
G TP53 tumor protein p53 multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TP53 protein] CTD PMID:28710020, PMID:32454083 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
G XPA XPA, DNA damage recognition and repair factor decreases expression EXP ochratoxin A results in decreased expression of XPA mRNA CTD PMID:14994279 NCBI chr 1:239,532,331...239,568,589
Ensembl chr 1:239,532,246...239,568,649
JBrowse link
G XRCC1 X-ray repair cross complementing 1 increases expression EXP ochratoxin A results in increased expression of XRCC1 protein CTD PMID:32454083 NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,686...50,425,710
JBrowse link
ochratoxin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NFE2L2 nuclear factor, erythroid 2 like 2 decreases activity EXP ochratoxin B results in decreased activity of NFE2L2 protein CTD PMID:18547704 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
oxytetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 multiple interactions
increases uptake
EXP Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]
SLCO1A2 protein results in increased uptake of Oxytetracycline
CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link
p-xylene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity
multiple interactions
affects response to substance
EXP 4-xylene results in increased activity of CASP3 protein
aspartyl-glutamyl-valyl-aspartal inhibits the reaction [4-xylene results in increased activity of CASP3 protein]
CASP3 protein affects the susceptibility to 4-xylene
CTD PMID:14705839 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CAT catalase multiple interactions EXP CAT protein inhibits the reaction [4-xylene results in increased secretion of Malondialdehyde] CTD PMID:12781212 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 increases activity
multiple interactions
EXP 4-xylene results in increased activity of CYP2E1 protein
Disulfiram inhibits the reaction [4-xylene results in increased activity of CYP2E1 protein]
CTD PMID:12781212 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,818
JBrowse link
paracetamol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDKN1A cyclin dependent kinase inhibitor 1A decreases expression EXP Acetaminophen results in decreased expression of CDKN1A protein CTD PMID:16330492 NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,359,455...32,363,761
JBrowse link
G TP53 tumor protein p53 decreases expression EXP Acetaminophen results in decreased expression of TP53 protein CTD PMID:16330492 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,643...52,953,819
JBrowse link
pendimethalin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B22 cytochrome P450 2B22 decreases response to substance EXP CYP2B22 protein results in decreased susceptibility to pendimethalin CTD PMID:16315095 NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,413
JBrowse link
pentachlorobenzene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 increases expression EXP pentachlorobenzene results in increased expression of CYP11A1 protein CTD PMID:21296658 NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478
JBrowse link
G CYP17A1 cytochrome P450 17A1 increases expression EXP pentachlorobenzene results in increased expression of CYP17A1 protein CTD PMID:21296658 NCBI chr14:113,805,616...113,820,445
Ensembl chr14:113,805,611...113,812,041
JBrowse link
G CYP19A2 cytochrome P450 19A2 increases expression EXP pentachlorobenzene results in increased expression of CYP19A1 protein CTD PMID:21296658 NCBI chr 1:120,652,172...120,695,899
Ensembl chr 1:120,367,667...120,695,899
JBrowse link
prostaglandin D2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 multiple interactions
increases expression
EXP BW A868C inhibits the reaction [Prostaglandin D2 results in increased expression of NOS3 mRNA]; Prostaglandin D2 inhibits the reaction [BW A868C results in decreased expression of NOS3 mRNA] CTD PMID:10644584 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,156...6,228,938
JBrowse link
prostaglandin J2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP17A1 cytochrome P450 17A1 multiple interactions EXP 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 mRNA] CTD PMID:11889176 NCBI chr14:113,805,616...113,820,445
Ensembl chr14:113,805,611...113,812,041
JBrowse link
G INS insulin multiple interactions EXP 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Androstenedione]; 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Testosterone]; 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 mRNA] CTD PMID:11889176 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
G LHB luteinizing hormone subunit beta multiple interactions EXP 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Androstenedione]; 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Testosterone]; 9-deoxy-delta-9-prostaglandin D2 inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 mRNA] CTD PMID:11889176 NCBI chr 6:54,263,574...54,269,286 JBrowse link
SB 203580 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP SB 203580 affects the reaction [etoxazole affects the phosphorylation of AKT1 protein] CTD PMID:31744678
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP SB 203580 inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA] CTD PMID:19265715, PMID:23380242 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP SB 203580 inhibits the reaction [etoxazole results in increased phosphorylation of MAPK1 protein] CTD PMID:31744678 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP SB 203580 inhibits the reaction [etoxazole results in increased phosphorylation of MAPK3 protein] CTD PMID:31744678 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP [SB 203580 co-treated with etoxazole] results in increased phosphorylation of MAPK8 protein CTD PMID:31744678 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,172,200
JBrowse link
G RPS6 ribosomal protein S6 multiple interactions EXP SB 203580 affects the reaction [etoxazole affects the phosphorylation of RPS6 protein] CTD PMID:31744678 NCBI chr 1:203,444,360...203,447,643
Ensembl chr 1:203,444,450...203,451,468
JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions EXP SB 203580 affects the reaction [etoxazole affects the phosphorylation of RPS6KB1 protein] CTD PMID:31744678 NCBI chr12:36,111,584...36,159,287 JBrowse link
G STAT1 signal transducer and activator of transcription 1 multiple interactions EXP SB 203580 inhibits the reaction [Cadmium results in increased phosphorylation of STAT1 protein] CTD PMID:21783819 NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260
JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions EXP SB 203580 inhibits the reaction [Cadmium results in increased phosphorylation of STAT3 protein] CTD PMID:21783819 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,993
JBrowse link
G VCAM1 vascular cell adhesion molecule 1 multiple interactions EXP SB 203580 inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA] CTD PMID:23380242 NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,908...117,511,226
JBrowse link
simvastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase multiple interactions
decreases expression
EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of HMGCR mRNA]
Simvastatin results in decreased expression of HMGCR mRNA
CTD PMID:17130282, PMID:19343539 NCBI chr 2:84,380,245...84,401,117
Ensembl chr 2:84,380,225...84,402,956
JBrowse link
G LDLR low density lipoprotein receptor multiple interactions
increases expression
EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of LDLR mRNA]
Simvastatin results in increased expression of LDLR mRNA
CTD PMID:17130282 NCBI chr 2:69,828,348...69,864,823
Ensembl chr 2:69,828,332...69,864,823
JBrowse link
G NPC1L1 NPC1 like intracellular cholesterol transporter 1 multiple interactions EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of NPC1L1 mRNA] CTD PMID:17130282 NCBI chr18:50,726,854...50,757,676
Ensembl chr18:50,726,894...50,757,649
JBrowse link
G NR4A3 nuclear receptor subfamily 4 group A member 3 decreases expression EXP Simvastatin results in decreased expression of NR4A3 mRNA CTD PMID:16005304 NCBI chr 1:241,569,867...241,611,735
Ensembl chr 1:241,569,905...241,611,734
JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions EXP [Ezetimibe co-treated with Simvastatin] results in increased expression of SREBF1 mRNA CTD PMID:17130282 NCBI chr12:60,733,967...60,750,951
Ensembl chr12:60,733,907...60,751,265
JBrowse link
G SREBF2 sterol regulatory element binding transcription factor 2 multiple interactions EXP Simvastatin promotes the reaction [Ezetimibe results in increased expression of SREBF2 mRNA] CTD PMID:17130282 NCBI chr 5:6,719,484...6,784,724
Ensembl chr 5:6,719,487...6,784,672
JBrowse link
sulfamethoxazole hydroxylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CALR calreticulin increases expression EXP sulfamethoxazole hydroxylamine results in increased expression of CALR protein CTD PMID:16005169 NCBI chr 2:66,098,263...66,102,074
Ensembl chr 2:66,098,225...66,102,340
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 decreases expression EXP sulfamethoxazole hydroxylamine results in decreased expression of HSP90B1 protein CTD PMID:16005169 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,507...80,531,005
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP sulfamethoxazole hydroxylamine results in increased expression of HSPA5 protein CTD PMID:16005169 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
tetracycline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1A2 solute carrier organic anion transporter family member 1A2 increases uptake
multiple interactions
EXP SLCO1A2 protein results in increased uptake of Tetracycline
Tetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Tetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]
CTD PMID:31287969 NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,037,218...52,131,789
JBrowse link
thymol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RYR1 ryanodine receptor 1 increases activity EXP Thymol results in increased activity of RYR1 protein CTD PMID:17641978 NCBI chr 6:47,339,759...47,458,457 JBrowse link
thymol sulfate(1-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RYR1 ryanodine receptor 1 increases activity EXP Thymol results in increased activity of RYR1 protein CTD PMID:17641978 NCBI chr 6:47,339,759...47,458,457 JBrowse link
toluene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity
affects response to substance
multiple interactions
EXP Toluene results in increased activity of CASP3 protein
CASP3 protein affects the susceptibility to Toluene
aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Toluene results in increased activity of CASP3 protein]
CTD PMID:14705839 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,749...45,763,773
JBrowse link
G CAT catalase multiple interactions EXP CAT protein inhibits the reaction [Toluene results in increased secretion of Malondialdehyde] CTD PMID:12781212 NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452
JBrowse link
G CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 multiple interactions
increases activity
EXP Disulfiram inhibits the reaction [Toluene results in increased activity of CYP2E1 protein] CTD PMID:12781212 NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,818
JBrowse link
U50488 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions EXP 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer inhibits the reaction [AGT protein results in increased secretion of Aldosterone] CTD PMID:22100847 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
G OPRK1 opioid receptor kappa 1 multiple interactions EXP 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer inhibits the reaction [OPRK1 protein results in increased transport of Barium] CTD PMID:12031848 NCBI chr 4:77,399,298...77,429,025
Ensembl chr 4:77,399,198...77,426,522
JBrowse link
valsartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen decreases activity EXP Valsartan results in decreased activity of AGT protein modified form CTD PMID:7890486 NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,672,428
JBrowse link
vanillic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PNLIP pancreatic lipase decreases activity EXP Vanillic Acid results in decreased activity of PNLIP protein CTD PMID:23738459 NCBI chr14:126,771,920...126,789,097
Ensembl chr14:126,771,920...126,789,160
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 880
    chemical entity 880
      group 843
        polyatomic entity 843
          molecule 739
            cyclic compound 647
              organic cyclic compound 647
                carbocyclic compound 169
                  1-nitrocyclohexene 0
                  3-(\{[(2S)-5-oxopyrrolidin-2-yl]methyl\}sulfonyl)-N-[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-L-alanin[N-(1-cyanocyclopropyl)]amide 0
                  alicyclic compound + 5
                  auxin a 0
                  benzenoid aromatic compound + 158
                  carbocyclic antibiotic + 0
                  carbopolycyclic compound + 27
                  cyclic hydrocarbon + 76
                  cyclitol carboxylic acid + 5
                  cyclo[18]carbon 0
                  cyclobutanes + 0
                  cyclopentanes + 0
                  cyclopropanes + 1
                  cyclopropenes + 0
                  dauca-4,7-diene 0
                  nitrocyclohexane 0
                  quinomethanes + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 880
    subatomic particle 865
      composite particle 865
        hadron 865
          baryon 865
            nucleon 865
              atomic nucleus 865
                atom 865
                  main group element atom 855
                    p-block element atom 852
                      p-block molecular entity 851
                        carbon group molecular entity 827
                          organic molecular entity 826
                            organic molecule 738
                              organic cyclic compound 647
                                carbocyclic compound 169
                                  1-nitrocyclohexene 0
                                  3-(\{[(2S)-5-oxopyrrolidin-2-yl]methyl\}sulfonyl)-N-[(1S)-2,2,2-trifluoro-1-(4-fluorophenyl)ethyl]-L-alanin[N-(1-cyanocyclopropyl)]amide 0
                                  alicyclic compound + 5
                                  auxin a 0
                                  benzenoid aromatic compound + 158
                                  carbocyclic antibiotic + 0
                                  carbopolycyclic compound + 27
                                  cyclic hydrocarbon + 76
                                  cyclitol carboxylic acid + 5
                                  cyclo[18]carbon 0
                                  cyclobutanes + 0
                                  cyclopentanes + 0
                                  cyclopropanes + 1
                                  cyclopropenes + 0
                                  dauca-4,7-diene 0
                                  nitrocyclohexane 0
                                  quinomethanes + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.