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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4-methylthio-2-oxobutanoic acid
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Accession:CHEBI:33574 term browser browse the term
Definition:A 2-oxo monocarboxylic acid derived from L-methionine via the action of methionine transaminase.
Synonyms:related_synonym: 2-Oxo-4-methylthiobutanoate;   2-keto-4-methylthiobutyric acid;   2-oxomethionine;   4-(METHYLSULFANYL)-2-OXOBUTANOIC ACID;   4-Methylthio-2-oxobutanoate;   Formula=C5H8O3S;   InChI=1S/C5H8O3S/c1-9-3-2-4(6)5(7)8/h2-3H2,1H3,(H,7,8);   InChIKey=SXFSQZDSUWACKX-UHFFFAOYSA-N;   SMILES=CSCCC(=O)C(O)=O;   alpha-oxo-gamma-methylthiobutyric acid
 alt_id: CHEBI:1902;   CHEBI:22458;   CHEBI:43720
 xref: Beilstein:1754666;   CAS:583-92-6;   DrugBank:DB02238;   KEGG:C01180;   KNApSAcK:C00007474;   LIPID_MAPS_instance:LMFA01060170
 xref_mesh: MESH:C014632
 xref: PDBeChem:KMT
 cyclic_relationship: is_conjugate_acid_of CHEBI:16723


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4-methylthio-2-oxobutanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ctbp2 C-terminal binding protein 2 decreases expression ISO 2-keto-4-methylthiobutyric acid results in decreased expression of CTBP2 protein CTD PMID:28414304 NCBI chr 1:205,001,354...205,030,565
Ensembl chr 1:205,001,396...205,040,755
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO 2-keto-4-methylthiobutyric acid results in decreased expression of CTNNB1 protein CTD PMID:28414304 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Kyat1 kynurenine aminotransferase 1 affects metabolic processing EXP KYAT1 protein affects the metabolism of 2-keto-4-methylthiobutyric acid CTD PMID:2711386 NCBI chr 3:8,752,289...8,785,617
Ensembl chr 3:8,752,625...8,766,433
JBrowse link
G Odc1 ornithine decarboxylase 1 decreases activity ISO 2-keto-4-methylthiobutyric acid results in decreased activity of ODC1 protein CTD PMID:16870157 NCBI chr 6:42,852,529...42,859,142
Ensembl chr 6:42,852,683...42,859,927
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19781
    role 19726
      application 19412
        pharmaceutical 19312
          drug 19312
            nutraceutical 12660
              L-methionine 3457
                4-methylthio-2-oxobutanoic acid 4
                  S-adenosyl-4-methylthio-2-oxobutanoic acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19781
    subatomic particle 19779
      composite particle 19779
        hadron 19779
          baryon 19779
            nucleon 19779
              atomic nucleus 19779
                atom 19779
                  main group element atom 19669
                    p-block element atom 19669
                      carbon group element atom 19588
                        carbon atom 19578
                          organic molecular entity 19578
                            organic group 18620
                              organic divalent group 18611
                                organodiyl group 18611
                                  carbonyl group 18526
                                    carbonyl compound 18526
                                      carboxylic acid 18202
                                        monocarboxylic acid 17606
                                          fatty acid 16003
                                            short-chain fatty acid 15690
                                              fatty acid 4:0 7864
                                                butyric acid 6222
                                                  methionine 3458
                                                    L-methionine 3457
                                                      4-methylthio-2-oxobutanoic acid 4
                                                        S-adenosyl-4-methylthio-2-oxobutanoic acid 0
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