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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tetrol
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Accession:CHEBI:33573 term browser browse the term
Definition:A polyol that contains 4 hydroxy groups.



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3,4-dihydroxyphenylethyleneglycol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Comt catechol-O-methyltransferase increases methylation ISO COMT protein results in increased methylation of 3,4-dihydroxyphenylglycol CTD PMID:11160877 NCBI chr11:82,568,052...82,587,642
Ensembl chr11:82,568,025...82,587,642
JBrowse link
G Mgll monoglyceride lipase affects response to substance ISO MGLL protein affects the susceptibility to 3,4-dihydroxyphenylglycol CTD PMID:21911610 NCBI chr 4:121,192,187...121,294,187
Ensembl chr 4:121,192,195...121,294,179
JBrowse link
G Plcb1 phospholipase C beta 1 multiple interactions
increases activity
EXP [3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein; Caffeine inhibits the reaction [3,4-dihydroxyphenylglycol results in increased activity of PLCB1 protein]; Caffeine inhibits the reaction [[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein]; Theophylline inhibits the reaction [3,4-dihydroxyphenylglycol results in increased activity of PLCB1 protein]; Theophylline inhibits the reaction [[3,4-dihydroxyphenylglycol co-treated with Guanosine 5'-O-(3-Thiotriphosphate)] results in increased activity of PLCB1 protein] CTD PMID:15998294 NCBI chr 3:122,059,968...122,772,896
Ensembl chr 3:122,060,031...122,772,869
JBrowse link
astragaloside IV term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of AKT1 mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of AKT1 protein CTD PMID:32344236 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP astragaloside A inhibits the reaction [Isoproterenol results in decreased expression of and results in decreased activity of ATP2A2 protein]; astragaloside A inhibits the reaction [Isoproterenol results in decreased expression of ATP2A2 mRNA] CTD PMID:17509559 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of BAX protein] CTD PMID:22278385 PMID:33285147 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of BCL2 protein] CTD PMID:33285147 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcs1l BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone multiple interactions ISO astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCS1L protein] CTD PMID:22278385 NCBI chr 9:76,164,925...76,168,940
Ensembl chr 9:76,164,932...76,168,938
JBrowse link
G Cacna1c calcium voltage-gated channel subunit alpha1 C multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of CACNA1C protein] CTD PMID:33285147 NCBI chr 4:151,764,138...152,379,454
Ensembl chr 4:151,764,138...152,379,648
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
astragaloside A inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein]; astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of and results in increased cleavage of CASP3 protein]
astragaloside A inhibits the reaction [Cisplatin results in increased expression of CASP3 protein]
CTD PMID:22278385 PMID:30842369 PMID:33285147 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of CHUK protein] CTD PMID:33285147 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of EGFR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of EGFR mRNA CTD PMID:32344236 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of FTH1 protein] CTD PMID:33285147 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP astragaloside A inhibits the reaction [Cisplatin results in increased expression of GPT protein] CTD PMID:30842369 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
ISO [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 mRNA; [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] results in increased expression of HMOX1 protein
astragaloside A results in increased expression of HMOX1 mRNA; astragaloside A results in increased expression of HMOX1 protein
CTD PMID:25422538 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL1B protein; astragaloside A inhibits the reaction [Cisplatin results in increased expression of IL1B protein]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL1B mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL1B protein] CTD PMID:25604657 PMID:30842369 PMID:32344236 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of IL6 protein; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL6 mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of IL6 protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of IL6 protein]
CTD PMID:25604657 PMID:32344236 PMID:33285147 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK1 protein] CTD PMID:33285147 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of MAPK3 protein] CTD PMID:33285147 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of MMP9 protein CTD PMID:32344236 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP astragaloside A inhibits the reaction [Taurocholic Acid results in increased activity of MPO protein] CTD PMID:25604657 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of and results in decreased phosphorylation of MTOR protein; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MTOR mRNA CTD PMID:32344236 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Muc5ac mucin 5AC, oligomeric mucus/gel-forming multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5AC mRNA; [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of MUC5AC protein CTD PMID:32344236 NCBI chr 1:196,864,375...196,896,475 JBrowse link
G Muc5b mucin 5B, oligomeric mucus/gel-forming multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased expression of MUC5B mRNA CTD PMID:32344236 NCBI chr 1:196,916,861...196,948,830
Ensembl chr 1:196,916,825...196,949,250
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions
affects localization
ISO [astragaloside A co-treated with ginsenoside Rg1 co-treated with ginsenoside Rb1 co-treated with notoginsenoside R1] affects the localization of NFE2L2 protein
astragaloside A affects the localization of NFE2L2 protein
CTD PMID:25422538 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP
ISO
astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIA mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIA protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased phosphorylation of NFKBIA protein]
CTD PMID:25604657 PMID:33285147 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions EXP astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIB mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of NFKBIB protein] CTD PMID:25604657 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862
JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP astragaloside A inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein] CTD PMID:30842369 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
JBrowse link
G Pln phospholamban multiple interactions EXP astragaloside A inhibits the reaction [Isoproterenol results in decreased phosphorylation of PLN protein] CTD PMID:17509559 NCBI chr20:32,629,537...32,639,559 JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP
ISO
astragaloside A inhibits the reaction [Taurocholic Acid affects the localization of RELA protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which affects the localization of RELA protein]
CTD PMID:25604657 PMID:33285147 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rho rhodopsin multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RHO mRNA] CTD PMID:33285147 NCBI chr 4:148,975,597...148,988,693
Ensembl chr 4:148,980,611...148,985,773
JBrowse link
G Rpe65 retinoid isomerohydrolase RPE65 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in decreased expression of RPE65 mRNA] CTD PMID:33285147 NCBI chr 2:248,766,497...248,798,403
Ensembl chr 2:248,766,612...248,798,403
JBrowse link
G Slc11a2 solute carrier family 11 member 2 multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of SLC11A2 protein] CTD PMID:33285147 NCBI chr 7:131,503,076...131,540,246
Ensembl chr 7:131,503,081...131,540,145
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions EXP astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of SOD1 mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in decreased expression of SOD1 protein] CTD PMID:25604657 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions EXP astragaloside A promotes the reaction [Taurocholic Acid results in decreased expression of SOD2 protein]; astragaloside A promotes the reaction [Taurocholic Acid results in increased expression of SOD2 mRNA] CTD PMID:25604657 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP astragaloside A inhibits the reaction [Cisplatin results in increased expression of SQSTM1 protein] CTD PMID:30842369 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tfrc transferrin receptor multiple interactions ISO astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TFRC protein] CTD PMID:33285147 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP [paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] affects the secretion of TIMP1 protein CTD PMID:32344236 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO
[paeonol co-treated with icariin co-treated with nobiletin co-treated with Ginsenosides co-treated with astragaloside A] results in decreased secretion of TNF protein; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of TNF mRNA]; astragaloside A inhibits the reaction [Taurocholic Acid results in increased expression of TNF protein]
astragaloside A inhibits the reaction [[Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of TNF protein]
CTD PMID:25604657 PMID:32344236 PMID:33285147 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
benzoylaconine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
ISO ABCB1 protein results in increased transport of benzoylaconine
[Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylaconine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylaconine
CTD PMID:23200901 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylaconine CTD PMID:23200901 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
benzoylmesaconine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
multiple interactions
ISO ABCB1 protein results in increased transport of benzoylmesaconine
[Cyclosporine results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylmesaconine; [Verapamil results in decreased activity of ABCB1 protein] which results in decreased transport of benzoylmesaconine
CTD PMID:23200901 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 multiple interactions ISO [verlukast results in decreased activity of ABCC2 protein] which results in decreased transport of benzoylmesaconine CTD PMID:23200901 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
conduritol B epoxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gba glucosylceramidase beta multiple interactions
decreases activity
ISO
EXP
[conduritol epoxide binds to and results in decreased activity of GBA protein] which results in increased expression of SNCA protein
conduritol epoxide analog results in decreased activity of GBA protein
[conduritol epoxide binds to and results in decreased activity of GBA protein] which affects the localization of SNCA protein; [conduritol epoxide binds to and results in decreased activity of GBA protein] which results in increased expression of SNCA protein
CTD PMID:9101438 PMID:19576930 NCBI chr 2:174,609,437...174,615,457
Ensembl chr 2:174,609,403...174,618,263
JBrowse link
G Snca synuclein alpha multiple interactions ISO [conduritol epoxide binds to and results in decreased activity of GBA protein] which affects the localization of SNCA protein; [conduritol epoxide binds to and results in decreased activity of GBA protein] which results in increased expression of SNCA protein CTD PMID:19576930 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262
JBrowse link
dipyridamole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb11 ATP binding cassette subfamily B member 11 multiple interactions
decreases activity
ISO Dipyridamole inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid]
Dipyridamole results in decreased activity of ABCB11 protein
CTD PMID:23956101 PMID:24014644 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 decreases activity
multiple interactions
ISO Dipyridamole results in decreased activity of ABCC4 protein
Dipyridamole inhibits the reaction [ABCC4 protein results in increased transport of Cyclic GMP]
CTD PMID:11856762 PMID:15827327 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Adora3 adenosine A3 receptor increases expression EXP Dipyridamole results in increased expression of ADORA3 protein CTD PMID:17101059
G Apoe apolipoprotein E multiple interactions ISO [Bezafibrate co-treated with Enalapril co-treated with Dipyridamole co-treated with Atorvastatin co-treated with Valsartan] results in decreased expression of APOE protein CTD PMID:19603250 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions ISO Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 protein] CTD PMID:20063052 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Casp1 caspase 1 increases activity EXP Dipyridamole results in increased activity of CASP1 protein CTD PMID:21832250 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP3 protein]; Palmitic Acid promotes the reaction [Dipyridamole results in increased activity of CASP3 protein] CTD PMID:17303086 PMID:22700542 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 increases activity
multiple interactions
ISO Dipyridamole results in increased activity of CASP7 protein
Palmitic Acid promotes the reaction [Dipyridamole results in increased activity of CASP7 protein]
CTD PMID:22700542 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 multiple interactions ISO Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP8 protein] CTD PMID:17303086 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP
ISO
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]; tin protoporphyrin IX inhibits the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 protein]]
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL2 protein]
CTD PMID:16765938 PMID:20940016 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Cd40lg CD40 ligand decreases secretion ISO Dipyridamole results in decreased secretion of CD40LG protein CTD PMID:16046616 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator multiple interactions ISO Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA alternative form]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA]; Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR protein] CTD PMID:17303086 NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
JBrowse link
G Cldn5 claudin 5 increases expression ISO Dipyridamole results in increased expression of CLDN5 mRNA CTD PMID:20711499 NCBI chr11:82,212,822...82,214,248 JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression
ISO
EXP
Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]
Dipyridamole results in decreased expression of COL1A1 mRNA
CTD PMID:7617123 PMID:11576339 PMID:12271277 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]] CTD PMID:11576339 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 decreases expression ISO Dipyridamole results in decreased expression of CXCL12 mRNA CTD PMID:20711499 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO mRNA]; Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO protein] CTD PMID:20063052 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Dusp1 dual specificity phosphatase 1 increases phosphorylation
multiple interactions
ISO
EXP
Dipyridamole results in increased phosphorylation of DUSP1 protein
DUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]]; HMOX1 mRNA affects the reaction [Dipyridamole results in increased phosphorylation of DUSP1 protein]
DUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
CTD PMID:16765938 PMID:19356721 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Enpp1 ectonucleotide pyrophosphatase/phosphodiesterase 1 decreases expression EXP Dipyridamole results in decreased expression of ENPP1 protein CTD PMID:21414308 NCBI chr 1:20,698,746...20,763,741
Ensembl chr 1:20,698,764...20,763,715
JBrowse link
G Fadd Fas associated via death domain increases expression
multiple interactions
ISO Dipyridamole results in increased expression of FADD mRNA
Dipyridamole inhibits the reaction [Adenosine results in decreased expression of FADD mRNA]
CTD PMID:17303086 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression ISO Dipyridamole results in increased expression of FOS mRNA CTD PMID:12730611 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions
EXP Dipyridamole results in increased expression of HMOX1 protein
HMOX1 mRNA affects the reaction [Dipyridamole results in increased phosphorylation of DUSP1 protein]
CTD PMID:19356721 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression ISO Dipyridamole results in decreased expression of ICAM1 mRNA CTD PMID:20711499 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased activity of IKBKB protein] CTD PMID:16765938 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO Dipyridamole promotes the reaction [8-bromocyclic GMP promotes the reaction [IL1B protein results in increased abundance of Nitrites]]; Dipyridamole promotes the reaction [Bucladesine promotes the reaction [IL1B protein results in increased abundance of Nitrites]]; Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]; KT 5720 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]]; KT 5823 inhibits the reaction [Dipyridamole promotes the reaction [IL1B protein results in increased abundance of Cyclic AMP]] CTD PMID:8904084 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 decreases expression ISO Dipyridamole results in decreased expression of IL2 mRNA CTD PMID:20711499 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:16765938 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Insr insulin receptor multiple interactions ISO Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased activity of INSR promoter]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR mRNA]; Dipyridamole inhibits the reaction [AICA ribonucleotide results in decreased expression of INSR protein] CTD PMID:15694368 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases activity ISO Dipyridamole results in decreased activity of KCNH2 protein CTD PMID:17146843 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Lep leptin multiple interactions
increases expression
EXP 1,3-dipropyl-8-cyclopentylxanthine inhibits the reaction [Dipyridamole results in increased expression of LEP protein] CTD PMID:10746648 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 increases activity ISO Dipyridamole results in increased activity of MAPK8 protein CTD PMID:11051267 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:16765938 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions
EXP
ISO
Dipyridamole results in increased expression of NOS2 mRNA; Dipyridamole results in increased expression of NOS2 protein
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]
CTD PMID:8904084 PMID:12271277 PMID:16765938 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nppb natriuretic peptide B increases expression ISO Dipyridamole results in increased expression of NPPB protein CTD PMID:18037770 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168
JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Dipyridamole inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047
JBrowse link
G Orm1 orosomucoid 1 multiple interactions
affects binding
ISO Dipyridamole inhibits the reaction [Warfarin binds to ORM1 protein alternative form]
Dipyridamole binds to ORM1 protein alternative form
CTD PMID:8946472 NCBI chr 5:76,766,637...76,776,149
Ensembl chr 5:76,772,941...76,776,154
JBrowse link
G Pde10a phosphodiesterase 10A multiple interactions ISO Dipyridamole inhibits the reaction [PDE10A protein results in increased hydrolysis of Cyclic AMP]; Dipyridamole inhibits the reaction [PDE10A protein results in increased hydrolysis of Cyclic GMP] CTD PMID:10373451 NCBI chr 1:51,765,743...52,218,086
Ensembl chr 1:51,770,132...52,216,563
JBrowse link
G Pde11a phosphodiesterase 11A multiple interactions ISO Dipyridamole inhibits the reaction [PDE11A protein results in increased hydrolysis of Cyclic GMP] CTD PMID:10725373 NCBI chr 3:60,913,562...61,297,154 JBrowse link
G Pde4b phosphodiesterase 4B increases expression ISO Dipyridamole results in increased expression of PDE4B mRNA CTD PMID:20711499 NCBI chr 5:116,799,827...117,367,707
Ensembl chr 5:116,799,971...117,367,696
JBrowse link
G Pde5a phosphodiesterase 5A decreases activity ISO Dipyridamole results in decreased activity of PDE5A protein CTD PMID:11051267 NCBI chr 2:210,858,515...211,003,480
Ensembl chr 2:210,858,063...210,999,701
JBrowse link
G Pde7a phosphodiesterase 7A multiple interactions ISO Dipyridamole inhibits the reaction [PDE7A protein results in increased hydrolysis of Cyclic AMP] CTD PMID:10618442 NCBI chr 2:101,714,767...101,806,853
Ensembl chr 2:101,718,444...101,806,681
JBrowse link
G Pde7b phosphodiesterase 7B multiple interactions ISO Dipyridamole inhibits the reaction [PDE7B protein results in increased hydrolysis of Cyclic AMP] CTD PMID:10618442 PMID:10814504 PMID:10872825 NCBI chr 1:15,174,001...15,493,267
Ensembl chr 1:15,182,704...15,492,900
JBrowse link
G Pde8a phosphodiesterase 8A multiple interactions ISO Dipyridamole inhibits the reaction [PDE8A protein results in increased metabolism of Cyclic AMP]
Dipyridamole inhibits the reaction [PDE8A protein results in increased hydrolysis of Cyclic AMP]
CTD PMID:9671792 PMID:12681444 NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024
JBrowse link
G Pde8b phosphodiesterase 8B multiple interactions ISO Dipyridamole inhibits the reaction [PDE8B protein results in increased hydrolysis of Cyclic AMP]; Dipyridamole inhibits the reaction [PDE8B protein results in increased metabolism of Cyclic AMP] CTD PMID:9784418 PMID:12681444 NCBI chr 2:26,275,117...26,479,725
Ensembl chr 2:26,276,635...26,509,209
JBrowse link
G Plat plasminogen activator, tissue type increases secretion
multiple interactions
ISO Dipyridamole results in increased secretion of PLAT protein
KT 5823 inhibits the reaction [Dipyridamole results in increased secretion of PLAT protein]
CTD PMID:15733978 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO
EXP
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; DUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]; triptolide inhibits the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; tin protoporphyrin IX inhibits the reaction [Dipyridamole inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
CTD PMID:16765938 PMID:20940016 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rcan1 regulator of calcineurin 1 affects binding ISO Dipyridamole binds to RCAN1 protein alternative form CTD PMID:19189965 NCBI chr11:31,622,208...31,702,150
Ensembl chr11:31,622,210...31,702,045
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Dipyridamole inhibits the reaction [SLC22A2 protein polymorphism results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]; Dipyridamole inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc29a1 solute carrier family 29 member 1 multiple interactions
decreases activity
ISO Dipyridamole inhibits the reaction [4-nitrobenzylthioinosine binds to SLC29A1 protein]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Dipyridamole promotes the reaction [4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]]
Dipyridamole inhibits the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Adenosine]; Dipyridamole inhibits the reaction [SLC29A1 protein results in increased uptake of Uridine]; Dipyridamole promotes the reaction [[SLC29A1 co-treated with Oxygen deficiency] affects the abundance of Adenosine]
Dipyridamole results in decreased activity of SLC29A1 protein
CTD PMID:9353301 PMID:9396714 PMID:10366666 PMID:11085929 PMID:11179696 More... NCBI chr 9:15,399,661...15,414,203
Ensembl chr 9:15,399,612...15,414,203
JBrowse link
G Slc29a2 solute carrier family 29 member 2 multiple interactions ISO Dipyridamole promotes the reaction [4-nitrobenzylthioinosine inhibits the reaction [[SLC29A1 protein co-treated with SLC29A2 protein] results in increased uptake of Uridine]]
Dipyridamole inhibits the reaction [SLC29A2 protein results in increased uptake of Uridine]
CTD PMID:10366666 PMID:11085929 NCBI chr 1:202,327,641...202,335,185
Ensembl chr 1:202,327,354...202,335,171
JBrowse link
G Slc47a1 solute carrier family 47 member 1 multiple interactions ISO Dipyridamole inhibits the reaction [SLC47A1 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) multiple interactions ISO Dipyridamole inhibits the reaction [SLC4A1 protein results in increased transport of Chlorides] CTD PMID:2511191 NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117
JBrowse link
G Spp1 secreted phosphoprotein 1 multiple interactions EXP Dinitrochlorobenzene inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]; Dipyridamole inhibits the reaction [Glucose results in increased expression of SPP1 mRNA]; Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]; DUSP1 mRNA affects the reaction [Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]]; KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in increased secretion of SPP1 protein]]; tin protoporphyrin IX inhibits the reaction [Dipyridamole inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]] CTD PMID:19356721 PMID:20453393 NCBI chr14:5,308,885...5,315,120
Ensembl chr14:5,308,885...5,315,162
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [TGFB1 protein results in increased expression of COL3A1 mRNA]] CTD PMID:11576339 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Th tyrosine hydroxylase decreases expression EXP Dipyridamole results in decreased expression of TH protein CTD PMID:17568153 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
JBrowse link
G Tnf tumor necrosis factor decreases expression ISO Dipyridamole results in decreased expression of TNF mRNA CTD PMID:20711499 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Txn1 thioredoxin 1 multiple interactions EXP Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]; KT 5823 inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Dipyridamole inhibits the reaction [Glucose results in decreased expression of TXN1 protein]] CTD PMID:20453393 NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 multiple interactions ISO Dipyridamole inhibits the reaction [UGT1A1 protein results in increased glucuronidation of anhydroicaritin] CTD PMID:30237061 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Vcam1 vascular cell adhesion molecule 1 decreases expression ISO Dipyridamole results in decreased expression of VCAM1 mRNA CTD PMID:20711499 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
JBrowse link
G Vegfa vascular endothelial growth factor A increases secretion
multiple interactions
ISO Dipyridamole results in increased secretion of VEGFA protein
Adenosine promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Heparitin Sulfate promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Hyaluronic Acid promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]; Lipopolysaccharides promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein]
CTD PMID:20067761 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
madecassoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO madecassoside results in decreased activity of CYP2C19 protein CTD PMID:21349323 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO madecassoside results in decreased activity of CYP3A4 protein CTD PMID:21349323 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
masoprocol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Afp alpha-fetoprotein affects binding EXP Masoprocol binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO Masoprocol results in decreased phosphorylation of AKT1 protein CTD PMID:19503098 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Alk ALK receptor tyrosine kinase multiple interactions
decreases activity
ISO Masoprocol affects the phosphorylation of and affects the activity of ALK protein mutant form
Masoprocol results in decreased activity of ALK protein
CTD PMID:19503098 NCBI chr 6:22,879,653...23,599,636
Ensembl chr 6:22,880,625...23,598,034
JBrowse link
G Alox12 arachidonate 12-lipoxygenase, 12S type multiple interactions
decreases activity
ISO
EXP
Masoprocol inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid]
Masoprocol results in decreased activity of ALOX12 protein
CTD PMID:3928952 PMID:6240459 PMID:9258337 PMID:17027136 PMID:23238474 NCBI chr10:54,958,263...54,970,542
Ensembl chr10:54,958,271...54,970,542
JBrowse link
G Alox15 arachidonate 15-lipoxygenase multiple interactions
decreases activity
EXP
ISO
Masoprocol inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA]
Masoprocol results in decreased activity of ALOX15 protein
[Masoprocol results in decreased activity of ALOX15 protein] which results in increased abundance of 13-hydroxy-9,11-octadecadienoic acid
CTD PMID:15574791 PMID:18984061 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Alox5 arachidonate 5-lipoxygenase affects response to substance
decreases activity
multiple interactions
ISO
EXP
ALOX5 protein affects the susceptibility to Masoprocol
Masoprocol results in decreased activity of ALOX5 protein
Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 mRNA]; Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein]
[Masoprocol results in decreased activity of ALOX5 protein] which results in decreased chemical synthesis of Leukotriene B4; [Masoprocol results in decreased activity of ALOX5 protein] which results in increased abundance of 15-hydroxy-5,8,11,13-eicosatetraenoic acid; Masoprocol inhibits the reaction [ALOX5 protein promotes the reaction [lysophosphatidic acid results in increased abundance of Hydrogen Peroxide]]
CTD PMID:2724698 PMID:2849922 PMID:3928952 PMID:6240459 PMID:10698703 More... NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
JBrowse link
G Ar androgen receptor affects binding EXP Masoprocol binds to AR protein CTD PMID:14565775 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression
multiple interactions
ISO Masoprocol results in increased expression of BAX protein
MYC affects the reaction [Masoprocol results in increased expression of BAX protein]
CTD PMID:15034932 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bid BH3 interacting domain death agonist multiple interactions ISO [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of BID protein CTD PMID:17645780 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720
JBrowse link
G Casp3 caspase 3 increases cleavage
multiple interactions
increases activity
ISO
EXP
Masoprocol results in increased cleavage of CASP3 protein
Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased cleavage of and results in increased activity of CASP3 protein]; Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of CASP3 protein]
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Masoprocol results in increased activity of CASP3 protein]; Masoprocol inhibits the reaction [FASL protein results in increased activity of CASP3 protein]
[Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein
CTD PMID:10203695 PMID:10653524 PMID:11470254 PMID:15034932 PMID:17645780 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 multiple interactions
increases expression
ISO [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein
Masoprocol inhibits the reaction [FASL protein results in increased activity of CASP8 protein]
Masoprocol results in increased expression of CASP8 protein
CTD PMID:10203695 PMID:17645780 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO Masoprocol results in increased activity of CASP9 protein CTD PMID:15034932 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions EXP Masoprocol inhibits the reaction [[Calcimycin co-treated with CCL5 protein] results in increased secretion of Leukotriene B4]; Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 mRNA]; Masoprocol inhibits the reaction [[CCL5 protein co-treated with Calcimycin] results in increased expression of ALOX5 protein] CTD PMID:18083043 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Masoprocol results in decreased expression of CCND1 protein CTD PMID:11953870 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdh1 cadherin 1 decreases methylation
increases expression
ISO Masoprocol results in decreased methylation of CDH1 promoter
Masoprocol results in increased expression of CDH1 mRNA; Masoprocol results in increased expression of CDH1 protein
CTD PMID:18418215 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A decreases methylation
increases expression
ISO Masoprocol results in decreased methylation of CDKN2A promoter
Masoprocol results in increased expression of CDKN2A mRNA; Masoprocol results in increased expression of CDKN2A protein
CTD PMID:18164318 NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions ISO Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of CHUK protein modified form] CTD PMID:17395008 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cryab crystallin, alpha B multiple interactions EXP Masoprocol promotes the reaction [sodium arsenite results in increased expression of CRYAB mRNA]; Masoprocol promotes the reaction [sodium arsenite results in increased expression of CRYAB protein] CTD PMID:8591993 NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157
JBrowse link
G Dio1 iodothyronine deiodinase 1 decreases activity ISO Masoprocol results in decreased activity of DIO1 protein CTD PMID:30561685 NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
JBrowse link
G Dio2 iodothyronine deiodinase 2 decreases activity ISO Masoprocol results in decreased activity of DIO2 protein CTD PMID:30561685 NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809
JBrowse link
G Dio3 iodothyronine deiodinase 3 decreases activity ISO Masoprocol results in decreased activity of DIO3 protein CTD PMID:30561685 NCBI chr 6:129,285,747...129,287,608
Ensembl chr 6:129,285,749...129,286,660
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO Masoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of ERBB2 protein] CTD PMID:18645000 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO Masoprocol binds to and results in increased activity of ESR1 protein CTD PMID:19063592 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Fas Fas cell surface death receptor increases expression ISO Masoprocol results in increased expression of FAS protein CTD PMID:17645780 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Faslg Fas ligand multiple interactions ISO
EXP
Masoprocol inhibits the reaction [FASL protein results in increased activity of CASP3 protein]; Masoprocol inhibits the reaction [FASL protein results in increased activity of CASP8 protein]
Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of FASLG protein]
CTD PMID:10203695 PMID:17651887 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fn1 fibronectin 1 multiple interactions ISO Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of CHUK protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of MAPK8 protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of MAPK9 protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of NFKBIA protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of RELA protein modified form]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK1 protein]; Masoprocol inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK3 protein] CTD PMID:17395008 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Masoprocol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]] CTD PMID:10692565 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fpr1 formyl peptide receptor 1 decreases activity ISO Masoprocol results in decreased activity of FPR1 protein CTD PMID:17520823 NCBI chr 1:58,745,019...58,756,776
Ensembl chr 1:58,747,246...58,756,559
JBrowse link
G Hmox1 heme oxygenase 1 increases expression EXP
ISO
Masoprocol results in increased expression of HMOX1 mRNA; Masoprocol results in increased expression of HMOX1 protein CTD PMID:18852027 PMID:23942037 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hsd11b2 hydroxysteroid 11-beta dehydrogenase 2 multiple interactions
increases expression
increases activity
ISO 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Masoprocol results in increased activity of HSD11B2 protein]; 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [Masoprocol results in increased expression of HSD11B2 mRNA]; [Masoprocol co-treated with 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid] results in decreased expression of HSD11B2 protein; [Masoprocol co-treated with Leukotriene B4] results in decreased expression of HSD11B2 protein; Leukotriene B4 inhibits the reaction [Masoprocol results in increased activity of HSD11B2 protein]; Masoprocol inhibits the reaction [Progesterone results in decreased activity of HSD11B2 protein]; Masoprocol promotes the reaction [Mifepristone results in increased activity of HSD11B2 protein] CTD PMID:10377029 PMID:18032417 NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO Masoprocol inhibits the reaction [IGF1 protein promotes the reaction [IGF1R protein results in increased phosphorylation of and results in increased activity of IGF1R protein]]; Masoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of ERBB2 protein]; Masoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein] CTD PMID:18491370 PMID:18645000 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions
decreases activity
ISO Masoprocol inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1R mRNA]; Masoprocol inhibits the reaction [Dihydrotestosterone results in increased expression of IGF1R protein]; Masoprocol inhibits the reaction [IGF1 protein promotes the reaction [IGF1R protein results in increased phosphorylation of and results in increased activity of IGF1R protein]]; Masoprocol inhibits the reaction [IGF1 protein results in increased phosphorylation of IGF1R protein]
Masoprocol results in decreased activity of IGF1R protein
CTD PMID:18491370 PMID:18645000 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases response to substance
ISO Masoprocol inhibits the reaction [Eicosapentaenoic Acid inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]]; Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]
Masoprocol results in decreased susceptibility to IL1B protein
Masoprocol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
CTD PMID:8186192 PMID:12573452 PMID:21211511 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il6 interleukin 6 multiple interactions ISO Masoprocol inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA] CTD PMID:8186192 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Iyd iodotyrosine deiodinase multiple interactions ISO Masoprocol inhibits the reaction [IYD protein results in increased metabolism of Monoiodotyrosine] CTD PMID:33352258 NCBI chr 1:40,003,999...40,019,323
Ensembl chr 1:40,004,041...40,019,319
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression
multiple interactions
ISO Masoprocol results in decreased expression of JUN mRNA
Masoprocol inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of [FOS protein co-treated with JUN protein]]
CTD PMID:10692565 PMID:15034932 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 multiple interactions EXP Masoprocol inhibits the reaction [[[Oxygen deficiency results in increased activity of ALOX15 protein] which results in increased chemical synthesis of 15-hydroxy-5,8,11,13-eicosatetraenoic acid] which results in decreased expression of KCNA5 mRNA] CTD PMID:18984061 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697
JBrowse link
G Krt1 keratin 1 multiple interactions ISO Masoprocol inhibits the reaction [Calcium results in increased expression of KRT1 mRNA] CTD PMID:12069687 NCBI chr 7:132,976,618...132,981,844
Ensembl chr 7:132,976,620...132,981,844
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Masoprocol inhibits the reaction [LHB protein results in increased abundance of Cyclic AMP]; Masoprocol inhibits the reaction [LHB protein results in increased abundance of Pregnenolone]; Masoprocol inhibits the reaction [LHB protein results in increased abundance of Testosterone] CTD PMID:6430271 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO Masoprocol inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK1 protein]
Masoprocol results in decreased phosphorylation of MAPK1 protein
CTD PMID:17395008 PMID:19503098 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation
multiple interactions
ISO Masoprocol results in decreased phosphorylation of MAPK3 protein
Masoprocol inhibits the reaction [FN1 protein modified form results in increased phosphorylation of MAPK3 protein]
CTD PMID:17395008 PMID:19503098 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of MAPK8 protein modified form] CTD PMID:17395008 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of MAPK9 protein modified form] CTD PMID:17395008 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions ISO Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of and results in increased secretion of MMP13 protein]; Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Masoprocol inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]; Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 protein] CTD PMID:17395008 PMID:21211511 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions
ISO Masoprocol results in increased expression of MYC protein
MYC affects the reaction [Masoprocol results in increased expression of BAX protein]; MYC affects the reaction [Masoprocol results in increased expression of MYC protein]; MYC affects the reaction [Masoprocol results in increased expression of TP53 protein]
CTD PMID:15034932 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP Masoprocol affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:18852027 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of NFKBIA protein modified form] CTD PMID:17395008 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Ngf nerve growth factor multiple interactions EXP Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGF mRNA]; Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGF protein] CTD PMID:17651887 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
JBrowse link
G Ngfr nerve growth factor receptor multiple interactions EXP Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR mRNA]; Masoprocol inhibits the reaction [pentaacetyl geniposide results in increased expression of NGFR protein] CTD PMID:17651887 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA] CTD PMID:22037733 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Odc1 ornithine decarboxylase 1 multiple interactions ISO Masoprocol inhibits the reaction [Benzoyl Peroxide results in increased activity of ODC1 protein] CTD PMID:2105358 NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440
JBrowse link
G Otc ornithine transcarbamylase multiple interactions EXP Masoprocol promotes the reaction [PRL protein results in increased activity of OTC protein] CTD PMID:3097147 NCBI chr  X:12,453,834...12,529,954
Ensembl chr  X:12,453,834...12,566,918
JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Masoprocol affects the reaction [[9,10-Dimethyl-1,2-benzanthracene co-treated with Tetradecanoylphorbol Acetate] affects the expression of PCNA protein] CTD PMID:25770929 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
JBrowse link
G Por cytochrome p450 oxidoreductase multiple interactions ISO Masoprocol inhibits the reaction [POR protein affects the reaction [Benzo(a)pyrene results in increased chemical synthesis of benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide-DNA]] CTD PMID:28111842 NCBI chr12:20,951,058...20,999,198
Ensembl chr12:20,951,058...20,999,245
JBrowse link
G Prl prolactin multiple interactions EXP Masoprocol promotes the reaction [PRL protein results in increased activity of OTC protein] CTD PMID:3097147 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Masoprocol inhibits the reaction [Eicosapentaenoic Acid inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]]; Masoprocol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:7575673 PMID:12573452 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rb1 RB transcriptional corepressor 1 decreases phosphorylation ISO Masoprocol results in decreased phosphorylation of RB1 protein CTD PMID:18164318 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Masoprocol inhibits the reaction [FN1 protein modified form results in increased expression of RELA protein modified form] CTD PMID:17395008 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Masoprocol binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057
JBrowse link
G Slc5a5 solute carrier family 5 member 5 multiple interactions EXP Masoprocol inhibits the reaction [TSHB protein results in increased expression of SLC5A5 mRNA] CTD PMID:17962351 NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697
JBrowse link
G Sod2 superoxide dismutase 2 multiple interactions ISO Masoprocol inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 mRNA]; Masoprocol inhibits the reaction [Arachidonic Acid results in increased expression of SOD2 protein]; Masoprocol inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA] CTD PMID:8760145 PMID:12031898 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO Masoprocol results in decreased phosphorylation of STAT3 protein CTD PMID:19503098 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions EXP Masoprocol inhibits the reaction [Puromycin Aminonucleoside results in increased expression of TGFB1 mRNA] CTD PMID:19194550 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases response to substance
ISO Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 mRNA]; Masoprocol inhibits the reaction [TNF protein results in increased expression of MMP13 protein]; Masoprocol inhibits the reaction [TNF protein results in increased expression of SOD2 mRNA]
Masoprocol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]
Masoprocol results in decreased susceptibility to TNF protein
CTD PMID:8186192 PMID:8760145 PMID:21211511 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions ISO [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of BID protein; [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP10 protein; [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP3 protein; [Masoprocol co-treated with TNFSF10 protein] results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:17645780 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO MYC affects the reaction [Masoprocol results in increased expression of TP53 protein] CTD PMID:15034932 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 multiple interactions EXP Masoprocol inhibits the reaction [[Melitten results in increased activity of TRPV1 protein] which results in increased transport of Calcium] CTD PMID:21453681 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513
JBrowse link
G Tshb thyroid stimulating hormone subunit beta multiple interactions EXP Masoprocol inhibits the reaction [TSHB protein results in increased expression of SLC5A5 mRNA] CTD PMID:17962351 NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation ISO UGT1A1 protein results in increased glucuronidation of Masoprocol CTD PMID:14557274 NCBI chr 9:88,801,344...88,808,465 JBrowse link
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 increases glucuronidation ISO UGT1A8 protein results in increased glucuronidation of Masoprocol CTD PMID:14557274 NCBI chr 9:88,727,094...88,808,465 JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Masoprocol CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465 JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO Masoprocol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased expression of VEGFA mRNA]; Masoprocol inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of VEGFA protein] CTD PMID:17520823 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
purpurogallin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP purpurogallin inhibits the reaction [CYP2E1 protein results in increased reduction of tirapazamine] CTD PMID:7710944 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    chemical entity 19823
      molecular entity 19821
        polyatomic entity 19743
          heteroatomic molecular entity 19685
            hydroxides 19175
              organic hydroxy compound 18666
                polyol 8078
                  tetrol 151
                    (20S,23,24)-trihydroxyvitamin D3 0
                    (20S,23,25)-trihydroxyvitamin D3 0
                    (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol 0
                    (3Z,6E)-3,6-bis(methoxyimino)hexane-1,2,4,5-tetrol 0
                    (7R)-7-hydroxylariciresinol 0
                    (R)-demethyl-4-deoxygadusol 0
                    (S)-demethyl-4-deoxygadusol 0
                    1-iminohexane-2,3,4,5-tetrol 0
                    19alpha-hydroxyasiatic acid + 0
                    19alpha-hydroxyasiatic acid-28-O-beta-D-glucopyrannoside 0
                    1alpha,23(S),25-trihydroxyvitamin D3 0
                    1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 + 0
                    1alpha,25-dihydroxy-2beta-(4-hydroxybutoxy)vitamin D3 0
                    2-amino-1,3,4,5-icosanetetrol 0
                    2-hydroxyrubiarbonone E 0
                    21-deoxyconcanamycin A 0
                    2alpha-(3-hydroxypropyl)-1alpha,25-dihydroxy-19-norvitamin D3 0
                    3,4-dihydroxyphenylethyleneglycol 3
                    3-deoxypentitol 0
                    35-amino-3-methylbacteriohopane-31,32,33,34-tetrol 0
                    35-aminobacteriohopane-31,32,33,34-tetrol 0
                    3beta,7beta,15alpha,22-tetrahydroxyhopane 0
                    5,5',6,6'-tetrahydroxy-3,3'-biindolyl 0
                    5,5,6,6-tetramethoxyhexane-1,2,3,4-tetrol 0
                    8-amino-8-demethylriboflavin + 0
                    8-demethyl-8-(methylamino)riboflavin 0
                    N-(3,4,5,6-tetrahydroxy-1-iminohexan-2-yl)acetamide 0
                    N-deethylaconine 0
                    anagalligenin A + 0
                    bacteriohopane-32,33,34,35-tetrol + 0
                    bacterioruberin 0
                    bellidin + 0
                    benzenetetrol + 0
                    benzoylaconine 2
                    benzoylmesaconine 2
                    bruceolide + 0
                    celesticetin 0
                    combretanone A 0
                    conduritol + 2
                    conduritol epoxide + 2
                    cryptocaryol B 0
                    cycloastragenol + 36
                    dehydroascorbic acid dimer 0
                    dihydropyriculol 0
                    dihydrostemphyloxin I 0
                    dipyridamole 60
                    ent-pavettamine 0
                    eucommiol 0
                    fumisoquin A 0
                    gemini-0072 0
                    gemini-0097 0
                    gigantetronenin 0
                    guaiacylglycerol + 0
                    hopane-6beta,11alpha,22,27-tetraol 0
                    hypaconine 0
                    lyratol C 0
                    madecassic acid + 2
                    nogalamycin 0
                    nordihydroguaiaretic acid + 72
                    oligomycin C 0
                    pavettamine 0
                    pentaerythritol 0
                    perquinoline C 0
                    prostaglandin E2 1-glyceryl ester 0
                    prostaglandin E2 2-glyceryl ester 0
                    prostaglandin F1alpha alcohol 0
                    protobassic acid + 0
                    purpurogallin 1
                    rel-2alpha,3alpha,19alpha,23-tetrahydroxyolean-12-en-28-oic acid 0
                    rostratin A 0
                    rubiarbonol A + 0
                    rubiyunnanol C 0
                    samaderine E 0
                    samaderine Z 0
                    saponaceol A 0
                    senbusine A 0
                    stemphyloxin I + 0
                    tanegool 0
                    taxiresinol 0
                    tetrahydroxysqualene 0
                    validone + 0
                    valienone + 0
                    weigelic acid 0
                    yadanziolide U 0
                    yadanziolide V 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      p-block molecular entity 19720
                        chalcogen molecular entity 19471
                          oxygen molecular entity 19447
                            hydroxides 19175
                              organic hydroxy compound 18666
                                polyol 8078
                                  tetrol 151
                                    (20S,23,24)-trihydroxyvitamin D3 0
                                    (20S,23,25)-trihydroxyvitamin D3 0
                                    (2R,4S)-2-methyltetrahydrofuran-2,3,3,4-tetrol 0
                                    (3Z,6E)-3,6-bis(methoxyimino)hexane-1,2,4,5-tetrol 0
                                    (7R)-7-hydroxylariciresinol 0
                                    (R)-demethyl-4-deoxygadusol 0
                                    (S)-demethyl-4-deoxygadusol 0
                                    1-iminohexane-2,3,4,5-tetrol 0
                                    19alpha-hydroxyasiatic acid + 0
                                    19alpha-hydroxyasiatic acid-28-O-beta-D-glucopyrannoside 0
                                    1alpha,23(S),25-trihydroxyvitamin D3 0
                                    1alpha,25-dihydroxy-2beta-(3-hydroxypropoxy)vitamin D3 + 0
                                    1alpha,25-dihydroxy-2beta-(4-hydroxybutoxy)vitamin D3 0
                                    2-amino-1,3,4,5-icosanetetrol 0
                                    2-hydroxyrubiarbonone E 0
                                    21-deoxyconcanamycin A 0
                                    2alpha-(3-hydroxypropyl)-1alpha,25-dihydroxy-19-norvitamin D3 0
                                    3,4-dihydroxyphenylethyleneglycol 3
                                    3-deoxypentitol 0
                                    35-amino-3-methylbacteriohopane-31,32,33,34-tetrol 0
                                    35-aminobacteriohopane-31,32,33,34-tetrol 0
                                    3beta,7beta,15alpha,22-tetrahydroxyhopane 0
                                    5,5',6,6'-tetrahydroxy-3,3'-biindolyl 0
                                    5,5,6,6-tetramethoxyhexane-1,2,3,4-tetrol 0
                                    8-amino-8-demethylriboflavin + 0
                                    8-demethyl-8-(methylamino)riboflavin 0
                                    N-(3,4,5,6-tetrahydroxy-1-iminohexan-2-yl)acetamide 0
                                    N-deethylaconine 0
                                    anagalligenin A + 0
                                    bacteriohopane-32,33,34,35-tetrol + 0
                                    bacterioruberin 0
                                    bellidin + 0
                                    benzenetetrol + 0
                                    benzoylaconine 2
                                    benzoylmesaconine 2
                                    bruceolide + 0
                                    celesticetin 0
                                    combretanone A 0
                                    conduritol + 2
                                    conduritol epoxide + 2
                                    cryptocaryol B 0
                                    cycloastragenol + 36
                                    dehydroascorbic acid dimer 0
                                    dihydropyriculol 0
                                    dihydrostemphyloxin I 0
                                    dipyridamole 60
                                    ent-pavettamine 0
                                    eucommiol 0
                                    fumisoquin A 0
                                    gemini-0072 0
                                    gemini-0097 0
                                    gigantetronenin 0
                                    guaiacylglycerol + 0
                                    hopane-6beta,11alpha,22,27-tetraol 0
                                    hypaconine 0
                                    lyratol C 0
                                    madecassic acid + 2
                                    nogalamycin 0
                                    nordihydroguaiaretic acid + 72
                                    oligomycin C 0
                                    pavettamine 0
                                    pentaerythritol 0
                                    perquinoline C 0
                                    prostaglandin E2 1-glyceryl ester 0
                                    prostaglandin E2 2-glyceryl ester 0
                                    prostaglandin F1alpha alcohol 0
                                    protobassic acid + 0
                                    purpurogallin 1
                                    rel-2alpha,3alpha,19alpha,23-tetrahydroxyolean-12-en-28-oic acid 0
                                    rostratin A 0
                                    rubiarbonol A + 0
                                    rubiyunnanol C 0
                                    samaderine E 0
                                    samaderine Z 0
                                    saponaceol A 0
                                    senbusine A 0
                                    stemphyloxin I + 0
                                    tanegool 0
                                    taxiresinol 0
                                    tetrahydroxysqualene 0
                                    validone + 0
                                    valienone + 0
                                    weigelic acid 0
                                    yadanziolide U 0
                                    yadanziolide V 0
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