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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:metal atom
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Accession:CHEBI:33521 term browser browse the term
Definition:An atom of an element that exhibits typical metallic properties, being typically shiny, with high electrical and thermal conductivity.
Synonyms:related_synonym: elemental metal;   elemental metals;   metal element;   metal elements;   metals
 alt_id: CHEBI:25217;   CHEBI:6788
 xref: KEGG:C00050;   PMID:21784043;   Wikipedia:Metal



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barium(0) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 multiple interactions EXP Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766
JBrowse link
G KCNJ6 potassium inwardly rectifying channel subfamily J member 6 multiple interactions EXP Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478
JBrowse link
cadmium atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSP70 heat shock protein 70 increases expression EXP Cadmium results in increased expression of HSP70 protein CTD PMID:12915104 NCBI chr12:1,285,282...1,287,670 JBrowse link
cadmium dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G OCLN occludin decreases expression EXP Cadmium Chloride results in decreased expression of OCLN protein CTD PMID:18418844 NCBI chr 2:54,500,299...54,545,430
Ensembl chr 2:54,500,299...54,545,430
JBrowse link
calcium atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC8A1 solute carrier family 8 member A1 increases transport
multiple interactions
increases uptake
EXP SLC8A1 protein results in increased transport of Calcium
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]; SEA 0400 inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]
CTD PMID:14660663 PMID:15375168 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700
JBrowse link
G TRPM8 transient receptor potential cation channel subfamily M member 8 multiple interactions EXP [icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium; [Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium; [mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium] CTD PMID:16386244 NCBI chr25:45,261,092...45,357,560
Ensembl chr25:45,261,107...45,353,282
JBrowse link
calcium(0) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC8A1 solute carrier family 8 member A1 increases transport
multiple interactions
increases uptake
EXP SLC8A1 protein results in increased transport of Calcium
2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]; SEA 0400 inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]
CTD PMID:14660663 PMID:15375168 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700
JBrowse link
G TRPM8 transient receptor potential cation channel subfamily M member 8 multiple interactions EXP [icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium; [Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium; [mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium] CTD PMID:16386244 NCBI chr25:45,261,092...45,357,560
Ensembl chr25:45,261,107...45,353,282
JBrowse link
cobalt atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G VIP vasoactive intestinal peptide decreases expression EXP Cobalt results in decreased expression of VIP protein CTD PMID:3711722 NCBI chr 1:42,941,655...42,950,160
Ensembl chr 1:42,941,224...42,950,700
JBrowse link
copper atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein increases expression EXP Copper results in increased expression of APP protein CTD PMID:16886094 NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337
JBrowse link
G COMMD1 copper metabolism domain containing 1 increases abundance
decreases export
EXP COMMD1 gene mutant form results in increased abundance of Copper
COMMD1 gene mutant form results in decreased export of Copper
CTD PMID:20433422 PMID:22879914 NCBI chr10:61,886,281...62,059,610
Ensembl chr10:61,886,281...62,059,591
JBrowse link
copper(0) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APP amyloid beta precursor protein increases expression EXP Copper results in increased expression of APP protein CTD PMID:16886094 NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337
JBrowse link
G COMMD1 copper metabolism domain containing 1 increases abundance
decreases export
EXP COMMD1 gene mutant form results in increased abundance of Copper
COMMD1 gene mutant form results in decreased export of Copper
CTD PMID:20433422 PMID:22879914 NCBI chr10:61,886,281...62,059,610
Ensembl chr10:61,886,281...62,059,591
JBrowse link
iron atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CP ceruloplasmin multiple interactions
increases export
EXP [CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron]
CP protein results in increased export of Iron
CTD PMID:16806171 NCBI chr23:43,969,297...44,033,226
Ensembl chr23:43,969,435...44,030,369
JBrowse link
G LOC477072 serotransferrin multiple interactions
increases export
EXP [CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron]
TF protein results in increased export of Iron
CTD PMID:16806171 NCBI chr23:30,658,250...30,683,816
Ensembl chr23:30,595,704...30,683,845
JBrowse link
iron(0) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CP ceruloplasmin multiple interactions
increases export
EXP [CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron]
CP protein results in increased export of Iron
CTD PMID:16806171 NCBI chr23:43,969,297...44,033,226
Ensembl chr23:43,969,435...44,030,369
JBrowse link
G LOC477072 serotransferrin multiple interactions
increases export
EXP [CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron]
TF protein results in increased export of Iron
CTD PMID:16806171 NCBI chr23:30,658,250...30,683,816
Ensembl chr23:30,595,704...30,683,845
JBrowse link
lead(II) chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases secretion EXP lead chloride results in increased secretion of EDN1 protein CTD PMID:15915659 NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383
JBrowse link
G EDN2 endothelin 2 increases secretion EXP lead chloride results in increased secretion of EDN2 protein CTD PMID:15915659 NCBI chr15:1,647,966...1,654,272
Ensembl chr15:1,648,077...1,654,272
JBrowse link
mercury atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 increases expression
multiple interactions
EXP Mercury results in increased expression of ABCC1 mRNA; Mercury results in increased expression of ABCC1 protein
ABCC1 protein affects the export of and results in decreased susceptibility to Mercury
CTD PMID:15590114 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 increases expression
multiple interactions
EXP Mercury results in increased expression of ABCC2 mRNA; Mercury results in increased expression of ABCC2 protein
ABCC2 protein affects the export of and results in decreased susceptibility to Mercury
CTD PMID:15590114 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740
JBrowse link
mercury dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 multiple interactions
increases expression
EXP ABCC1 protein affects the export of and results in decreased susceptibility to Mercuric Chloride
Mercuric Chloride results in increased expression of ABCC1 mRNA; Mercuric Chloride results in increased expression of ABCC1 protein
CTD PMID:15590114 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 multiple interactions
increases expression
EXP ABCC2 protein affects the export of and results in decreased susceptibility to Mercuric Chloride
Mercuric Chloride results in increased expression of ABCC2 mRNA; Mercuric Chloride results in increased expression of ABCC2 protein
CTD PMID:15590114 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740
JBrowse link
G LOC100686073 metallothionein-1 increases expression EXP Mercuric Chloride results in increased expression of MT1 mRNA CTD PMID:15590114 NCBI chr 2:59,603,021...59,604,173
Ensembl chr 2:59,603,014...59,604,132
JBrowse link
G MT2A metallothionein 1H increases expression EXP Mercuric Chloride results in increased expression of MT2 mRNA CTD PMID:15590114 NCBI chr 2:59,607,926...59,608,825
Ensembl chr 2:59,607,927...59,626,727
JBrowse link
mercury(0) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 increases expression
multiple interactions
EXP Mercury results in increased expression of ABCC1 mRNA; Mercury results in increased expression of ABCC1 protein
ABCC1 protein affects the export of and results in decreased susceptibility to Mercury
CTD PMID:15590114 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 increases expression
multiple interactions
EXP Mercury results in increased expression of ABCC2 mRNA; Mercury results in increased expression of ABCC2 protein
ABCC2 protein affects the export of and results in decreased susceptibility to Mercury
CTD PMID:15590114 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740
JBrowse link
metamizole sodium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Dipyrone results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
nitroprusside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POMC proopiomelanocortin increases expression EXP Nitroprusside results in increased expression of POMC protein CTD PMID:2831029 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
JBrowse link
G REN renin increases activity EXP Nitroprusside results in increased activity of REN protein CTD PMID:2434793 PMID:6399253 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
G WT1 WT1 transcription factor multiple interactions EXP [Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA CTD PMID:21443142 NCBI chr18:35,099,660...35,148,767
Ensembl chr18:35,103,934...35,148,000
JBrowse link
potassium atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin multiple interactions EXP [INS protein co-treated with Glucose] results in decreased abundance of Potassium CTD PMID:140932 PMID:1013176 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
JBrowse link
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 multiple interactions EXP [KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium; Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]; Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766
JBrowse link
G KCNJ6 potassium inwardly rectifying channel subfamily J member 6 multiple interactions EXP [KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium; Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]; Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478
JBrowse link
sodium arsenite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSR glutathione-disulfide reductase multiple interactions
decreases activity
EXP [monoisoamyl-2,3-dimercaptosuccinate co-treated with Succimer] inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] CTD PMID:18163546 NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752
JBrowse link
sodium atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin multiple interactions
affects response to substance
EXP INS protein promotes the reaction [Sodium results in increased abundance of Vasopressins]; Sodium affects the reaction [INS protein affects the abundance of Hydrocortisone]
INS protein affects the susceptibility to Sodium
CTD PMID:1324617 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
JBrowse link
sodium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 increases expression
multiple interactions
EXP Sodium Chloride results in increased expression of CLDN4 protein
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]
CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression
multiple interactions
EXP Sodium Chloride results in increased expression of JUN protein
pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]; U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]
CTD PMID:23816505 NCBI chr 5:50,966,698...50,968,939 JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation
multiple interactions
EXP Sodium Chloride results in increased phosphorylation of MAPK1 protein
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]
CTD PMID:23816505 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions
EXP Sodium Chloride results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]
CTD PMID:23816505 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions
increases phosphorylation
EXP Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation
EXP Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Sodium Chloride results in increased expression of SOD2 protein CTD PMID:22718889 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
JBrowse link
G SP1 Sp1 transcription factor multiple interactions
increases expression
EXP pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein]; Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]; U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein] CTD PMID:23816505 NCBI chr27:1,802,587...1,861,187
Ensembl chr27:1,805,184...1,847,226
JBrowse link
zinc oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAT catalase decreases activity EXP Zinc Oxide results in decreased activity of CAT protein CTD PMID:28126643 NCBI chr18:33,383,005...33,422,447
Ensembl chr18:33,383,005...33,422,447
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 407
    chemical entity 407
      atom 407
        metal atom 32
          alkali metal atom + 13
          alkaline earth metal atom + 4
          alloy + 0
          aluminium atom + 0
          bismuth atom + 0
          d-block element atom + 15
          heavy metal 0
          lead atom + 2
          metal allergen + 3
          polonium atom + 0
          tin atom + 0
          transition element atom + 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 407
    subatomic particle 407
      composite particle 407
        hadron 407
          baryon 407
            nucleon 407
              atomic nucleus 407
                atom 407
                  metal atom 32
                    alkali metal atom + 13
                    alkaline earth metal atom + 4
                    alloy + 0
                    aluminium atom + 0
                    bismuth atom + 0
                    d-block element atom + 15
                    heavy metal 0
                    lead atom + 2
                    metal allergen + 3
                    polonium atom + 0
                    tin atom + 0
                    transition element atom + 15
paths to the root