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G |
KCNJ3 |
potassium inwardly rectifying channel subfamily J member 3 |
multiple interactions |
EXP |
Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] |
CTD |
PMID:10666054 |
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NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766
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G |
KCNJ6 |
potassium inwardly rectifying channel subfamily J member 6 |
multiple interactions |
EXP |
Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] |
CTD |
PMID:10666054 |
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NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478
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G |
HSP70 |
heat shock protein 70 |
increases expression |
EXP |
Cadmium results in increased expression of HSP70 protein |
CTD |
PMID:12915104 |
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NCBI chr12:1,285,282...1,287,670
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G |
OCLN |
occludin |
decreases expression |
EXP |
Cadmium Chloride results in decreased expression of OCLN protein |
CTD |
PMID:18418844 |
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NCBI chr 2:54,500,299...54,545,430
Ensembl chr 2:54,500,299...54,545,430
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G |
SLC8A1 |
solute carrier family 8 member A1 |
increases transport multiple interactions increases uptake |
EXP |
SLC8A1 protein results in increased transport of Calcium 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]; SEA 0400 inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium] |
CTD |
PMID:14660663 PMID:15375168 |
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NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700
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G |
TRPM8 |
transient receptor potential cation channel subfamily M member 8 |
multiple interactions |
EXP |
[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium; [Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium; [mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium] |
CTD |
PMID:16386244 |
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NCBI chr25:45,261,092...45,357,560
Ensembl chr25:45,261,107...45,353,282
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G |
CASP3 |
caspase 3 |
multiple interactions increases activity |
EXP |
Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP3 protein] |
CTD |
PMID:25446497 |
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NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
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G |
CASP9 |
caspase 9 |
increases activity multiple interactions |
EXP |
Calcium Oxalate results in increased activity of CASP9 protein Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP9 protein] |
CTD |
PMID:25446497 |
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NCBI chr 2:82,033,759...82,076,710
Ensembl chr 2:82,031,563...82,090,484
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G |
TJP1 |
tight junction protein 1 |
multiple interactions decreases expression |
EXP |
Docetaxel inhibits the reaction [Calcium Oxalate results in decreased expression of TJP1 protein]; Phalloidine inhibits the reaction [Calcium Oxalate results in decreased expression of TJP1 protein] |
CTD |
PMID:34147488 PMID:36349591 |
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NCBI chr 3:38,997,122...39,076,617
Ensembl chr 3:38,997,076...39,241,574
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G |
SLC8A1 |
solute carrier family 8 member A1 |
increases transport multiple interactions increases uptake |
EXP |
SLC8A1 protein results in increased transport of Calcium 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased transport of Calcium]; 2-(2-(4-(4-nitrobenzyloxy)phenyl)ethyl)isothiourea methanesulfonate inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium]; SEA 0400 inhibits the reaction [SLC8A1 protein results in increased uptake of Calcium] |
CTD |
PMID:14660663 PMID:15375168 |
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NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700
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G |
TRPM8 |
transient receptor potential cation channel subfamily M member 8 |
multiple interactions |
EXP |
[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium; [Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium; [mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[icilin results in increased activity of TRPM8 protein] which results in increased transport of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[Menthol results in increased activity of TRPM8 protein] which results in increased transport of Calcium]; N-(4-tert-butylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carboxamide inhibits the reaction [[mustard oil results in increased activity of TRPM8 protein] which results in increased transport of Calcium] |
CTD |
PMID:16386244 |
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NCBI chr25:45,261,092...45,357,560
Ensembl chr25:45,261,107...45,353,282
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G |
VIP |
vasoactive intestinal peptide |
decreases expression |
EXP |
Cobalt results in decreased expression of VIP protein |
CTD |
PMID:3711722 |
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NCBI chr 1:42,941,655...42,950,160
Ensembl chr 1:42,941,224...42,950,700
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G |
APP |
amyloid beta precursor protein |
increases expression |
EXP |
Copper results in increased expression of APP protein |
CTD |
PMID:16886094 |
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NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337
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G |
COMMD1 |
copper metabolism domain containing 1 |
increases abundance decreases export |
EXP |
COMMD1 gene mutant form results in increased abundance of Copper COMMD1 gene mutant form results in decreased export of Copper |
CTD |
PMID:20433422 PMID:22879914 |
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NCBI chr10:61,886,281...62,059,610
Ensembl chr10:61,886,281...62,059,591
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G |
APP |
amyloid beta precursor protein |
increases expression |
EXP |
Copper results in increased expression of APP protein |
CTD |
PMID:16886094 |
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NCBI chr31:21,351,207...21,614,466
Ensembl chr31:21,351,207...21,614,337
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G |
COMMD1 |
copper metabolism domain containing 1 |
increases abundance decreases export |
EXP |
COMMD1 gene mutant form results in increased abundance of Copper COMMD1 gene mutant form results in decreased export of Copper |
CTD |
PMID:20433422 PMID:22879914 |
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NCBI chr10:61,886,281...62,059,610
Ensembl chr10:61,886,281...62,059,591
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G |
CP |
ceruloplasmin |
multiple interactions increases export |
EXP |
[CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron] CP protein results in increased export of Iron |
CTD |
PMID:16806171 |
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NCBI chr23:43,969,297...44,033,226
Ensembl chr23:43,969,435...44,030,369
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G |
LOC477072 |
serotransferrin |
multiple interactions increases export |
EXP |
[CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron] TF protein results in increased export of Iron |
CTD |
PMID:16806171 |
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NCBI chr23:30,658,250...30,683,816
Ensembl chr23:30,595,704...30,683,845
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G |
CP |
ceruloplasmin |
multiple interactions increases export |
EXP |
[CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron] CP protein results in increased export of Iron |
CTD |
PMID:16806171 |
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NCBI chr23:43,969,297...44,033,226
Ensembl chr23:43,969,435...44,030,369
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G |
LOC477072 |
serotransferrin |
multiple interactions increases export |
EXP |
[CP protein co-treated with TF protein] results in increased export of Iron; CP protein promotes the reaction [TF protein binds to Iron] TF protein results in increased export of Iron |
CTD |
PMID:16806171 |
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NCBI chr23:30,658,250...30,683,816
Ensembl chr23:30,595,704...30,683,845
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G |
EDN1 |
endothelin 1 |
increases secretion |
EXP |
lead chloride results in increased secretion of EDN1 protein |
CTD |
PMID:15915659 |
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NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383
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G |
EDN2 |
endothelin 2 |
increases secretion |
EXP |
lead chloride results in increased secretion of EDN2 protein |
CTD |
PMID:15915659 |
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NCBI chr15:1,647,966...1,654,272
Ensembl chr15:1,648,077...1,654,272
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G |
ABCC1 |
ATP binding cassette subfamily C member 1 |
increases expression multiple interactions |
EXP |
Mercury results in increased expression of ABCC1 mRNA; Mercury results in increased expression of ABCC1 protein ABCC1 protein affects the export of and results in decreased susceptibility to Mercury |
CTD |
PMID:15590114 |
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NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
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G |
ABCC2 |
ATP binding cassette subfamily C member 2 |
increases expression multiple interactions |
EXP |
Mercury results in increased expression of ABCC2 mRNA; Mercury results in increased expression of ABCC2 protein ABCC2 protein affects the export of and results in decreased susceptibility to Mercury |
CTD |
PMID:15590114 |
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NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740
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G |
ABCC1 |
ATP binding cassette subfamily C member 1 |
multiple interactions increases expression |
EXP |
ABCC1 protein affects the export of and results in decreased susceptibility to Mercuric Chloride Mercuric Chloride results in increased expression of ABCC1 mRNA; Mercuric Chloride results in increased expression of ABCC1 protein |
CTD |
PMID:15590114 |
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NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
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G |
ABCC2 |
ATP binding cassette subfamily C member 2 |
multiple interactions increases expression |
EXP |
ABCC2 protein affects the export of and results in decreased susceptibility to Mercuric Chloride Mercuric Chloride results in increased expression of ABCC2 mRNA; Mercuric Chloride results in increased expression of ABCC2 protein |
CTD |
PMID:15590114 |
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NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740
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G |
LOC100686073 |
metallothionein-1 |
increases expression |
EXP |
Mercuric Chloride results in increased expression of MT1 mRNA |
CTD |
PMID:15590114 |
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NCBI chr 2:59,603,021...59,604,173
Ensembl chr 2:59,603,014...59,604,132
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G |
MT2A |
metallothionein 1H |
increases expression |
EXP |
Mercuric Chloride results in increased expression of MT2 mRNA |
CTD |
PMID:15590114 |
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NCBI chr 2:59,607,926...59,608,825
Ensembl chr 2:59,607,927...59,626,727
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G |
ABCC1 |
ATP binding cassette subfamily C member 1 |
increases expression multiple interactions |
EXP |
Mercury results in increased expression of ABCC1 mRNA; Mercury results in increased expression of ABCC1 protein ABCC1 protein affects the export of and results in decreased susceptibility to Mercury |
CTD |
PMID:15590114 |
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NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
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G |
ABCC2 |
ATP binding cassette subfamily C member 2 |
increases expression multiple interactions |
EXP |
Mercury results in increased expression of ABCC2 mRNA; Mercury results in increased expression of ABCC2 protein ABCC2 protein affects the export of and results in decreased susceptibility to Mercury |
CTD |
PMID:15590114 |
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NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740
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G |
PTGS1 |
prostaglandin-endoperoxide synthase 1 |
decreases activity |
EXP |
Dipyrone results in decreased activity of PTGS1 protein alternative form |
CTD |
PMID:12242329 |
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NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
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G |
POMC |
proopiomelanocortin |
increases expression |
EXP |
Nitroprusside results in increased expression of POMC protein |
CTD |
PMID:2831029 |
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NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
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G |
REN |
renin |
increases activity |
EXP |
Nitroprusside results in increased activity of REN protein |
CTD |
PMID:2434793 PMID:6399253 |
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NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
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G |
WT1 |
WT1 transcription factor |
multiple interactions |
EXP |
[Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA |
CTD |
PMID:21443142 |
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NCBI chr18:35,099,660...35,148,767
Ensembl chr18:35,103,934...35,148,000
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G |
INS |
insulin |
multiple interactions |
EXP |
[INS protein co-treated with Glucose] results in decreased abundance of Potassium |
CTD |
PMID:140932 PMID:1013176 |
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NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
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G |
KCNJ3 |
potassium inwardly rectifying channel subfamily J member 3 |
multiple interactions |
EXP |
[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium; Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]; Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] |
CTD |
PMID:10666054 |
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NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766
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G |
KCNJ6 |
potassium inwardly rectifying channel subfamily J member 6 |
multiple interactions |
EXP |
[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium; Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium]; Barium inhibits the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] |
CTD |
PMID:10666054 |
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NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478
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G |
GSR |
glutathione-disulfide reductase |
multiple interactions decreases activity |
EXP |
[monoisoamyl-2,3-dimercaptosuccinate co-treated with Succimer] inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] |
CTD |
PMID:18163546 |
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NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752
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G |
HSP70 |
heat shock protein 70 |
increases expression multiple interactions |
EXP |
sodium arsenite results in increased expression of HSP70 protein carvacrol promotes the reaction [sodium arsenite results in increased expression of HSP70 protein]; leucinostatin A promotes the reaction [sodium arsenite results in increased expression of HSP70 protein] |
CTD |
PMID:31940135 |
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NCBI chr12:1,285,282...1,287,670
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G |
INS |
insulin |
multiple interactions affects response to substance |
EXP |
INS protein promotes the reaction [Sodium results in increased abundance of Vasopressins]; Sodium affects the reaction [INS protein affects the abundance of Hydrocortisone] INS protein affects the susceptibility to Sodium |
CTD |
PMID:1324617 |
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NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
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G |
CLDN4 |
claudin 4 |
increases expression multiple interactions |
EXP |
Sodium Chloride results in increased expression of CLDN4 protein Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; diphenyleneiodonium inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; manganese(III)-tetrakis(4-benzoic acid)porphyrin inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] |
CTD |
PMID:23816505 |
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NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
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G |
JUN |
Jun proto-oncogene, AP-1 transcription factor subunit |
increases expression multiple interactions |
EXP |
Sodium Chloride results in increased expression of JUN protein pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]; U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]] |
CTD |
PMID:23816505 |
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NCBI chr 5:50,966,698...50,968,939
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G |
MAPK1 |
mitogen-activated protein kinase 1 |
increases phosphorylation multiple interactions |
EXP |
Sodium Chloride results in increased phosphorylation of MAPK1 protein Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:23816505 |
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NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
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G |
MAPK3 |
mitogen-activated protein kinase 3 |
increases phosphorylation multiple interactions |
EXP |
Sodium Chloride results in increased phosphorylation of MAPK3 protein Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:23816505 |
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NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
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G |
MAPK8 |
mitogen-activated protein kinase 8 |
multiple interactions increases phosphorylation |
EXP |
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:23816505 |
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NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
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G |
MAPK9 |
mitogen-activated protein kinase 9 |
multiple interactions increases phosphorylation |
EXP |
Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:23816505 |
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NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
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G |
SOD2 |
superoxide dismutase 2 |
increases expression |
EXP |
Sodium Chloride results in increased expression of SOD2 protein |
CTD |
PMID:22718889 |
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NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
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G |
SP1 |
Sp1 transcription factor |
multiple interactions increases expression |
EXP |
pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein]; Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]; U 0126 inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; U 0126 inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein] |
CTD |
PMID:23816505 |
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NCBI chr27:1,802,587...1,861,187
Ensembl chr27:1,805,184...1,847,226
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G |
CAT |
catalase |
decreases activity |
EXP |
Zinc Oxide results in decreased activity of CAT protein |
CTD |
PMID:28126643 |
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NCBI chr18:33,383,005...33,422,447
Ensembl chr18:33,383,005...33,422,447
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