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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:selenium oxoacid
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Accession:CHEBI:33489 term browser browse the term
Synonyms:related_synonym: oxoacids of selenium;   selenium oxoacids


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selenic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions
decreases expression 		EXP Selenic Acid deficiency inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AHR mRNA]; Selenic Acid inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of AHR mRNA]
Selenic Acid deficiency results in decreased expression of AHR mRNA; Selenic Acid results in decreased expression of AHR mRNA 		CTD PMID:23644946 NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:57,961,423...57,998,901 		JBrowse link
G Aqp9 aquaporin 9 increases uptake
multiple interactions 		ISO AQP9 protein results in increased uptake of Selenic Acid analog
arsenite inhibits the reaction [AQP9 protein results in increased uptake of Selenic Acid analog]; Phloretin inhibits the reaction [AQP9 protein results in increased uptake of Selenic Acid analog] 		CTD PMID:28798983 NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240 		JBrowse link
G Casp3 caspase 3 increases activity ISO Selenic Acid results in increased activity of CASP3 protein CTD PMID:21215776 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions EXP Selenic Acid deficiency promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA]; Selenic Acid promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1A1 mRNA] CTD PMID:23644946 NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012 		JBrowse link
G Fbp1 fructose-bisphosphatase 1 decreases expression
decreases activity 		ISO Selenic Acid results in decreased expression of FBP1 mRNA
Selenic Acid results in decreased activity of FBP1 protein 		CTD PMID:16443359 NCBI chr17:2,212,941...2,235,749
Ensembl chr17:2,213,492...2,235,746 		JBrowse link
G Fus Fus RNA binding protein multiple interactions
affects localization 		ISO Selenic Acid promotes the reaction [TUBA4A protein binds to FUS protein]
Selenic Acid affects the localization of FUS protein 		CTD PMID:31585128 NCBI chr 1:192,007,011...192,020,887
Ensembl chr 1:192,007,006...192,020,884 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases activity
increases expression 		ISO Selenic Acid results in increased activity of GPX1 protein
Selenic Acid results in increased expression of GPX1 protein 		CTD PMID:16443359 PMID:31585128 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:117,905,280...117,906,581 		JBrowse link
G Gsr glutathione-disulfide reductase increases expression ISO Selenic Acid results in increased expression of GSR protein CTD PMID:21215776 NCBI chr16:65,185,574...65,228,742
Ensembl chr16:65,185,574...65,228,394 		JBrowse link
G Gusb glucuronidase, beta multiple interactions EXP Selenic Acid inhibits the reaction [Benzene affects the localization of and results in decreased activity of GUSB protein] CTD PMID:79528 NCBI chr12:32,337,281...32,350,838
Ensembl chr12:32,334,075...32,363,024 		JBrowse link
G Lck LCK proto-oncogene, Src family tyrosine kinase increases expression ISO Selenic Acid results in increased expression of LCK mRNA CTD PMID:16444006 NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:147,172,642...147,201,267 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation ISO Selenic Acid results in decreased phosphorylation of MAPK1 protein CTD PMID:21215776 NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 decreases phosphorylation ISO Selenic Acid results in decreased phosphorylation of MAPK3 protein CTD PMID:21215776 NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411 		JBrowse link
G Mbp myelin basic protein affects expression EXP Selenic Acid affects the expression of MBP mRNA CTD PMID:22954530 NCBI chr18:78,130,652...78,241,174
Ensembl chr18:78,130,325...78,241,174 		JBrowse link
G Nos1 nitric oxide synthase 1 increases expression ISO Selenic Acid results in increased expression of NOS1 protein CTD PMID:21215776 NCBI chr12:44,276,011...44,456,371
Ensembl chr12:44,287,614...44,371,837 		JBrowse link
G Papss1 3'-phosphoadenosine 5'-phosphosulfate synthase 1 multiple interactions ISO PAPSS1 protein binds to and affects the metabolism of Selenic Acid CTD PMID:15065880 NCBI chr 2:222,646,103...222,788,475
Ensembl chr 2:222,714,487...222,788,670 		JBrowse link
G Pc pyruvate carboxylase decreases activity ISO Selenic Acid results in decreased activity of PCX protein CTD PMID:16443359 NCBI chr 1:211,228,708...211,327,792
Ensembl chr 1:211,228,731...211,329,940 		JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 decreases expression ISO Selenic Acid results in decreased expression of PCK1 mRNA CTD PMID:16443359 NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:182,348,572...182,354,561 		JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 increases expression ISO Selenic Acid results in increased expression of IPF1 mRNA CTD PMID:18538137 NCBI chr12:12,793,957...12,799,156
Ensembl chr12:12,793,957...12,799,156 		JBrowse link
G Pon1 paraoxonase 1 multiple interactions
decreases expression
increases activity 		EXP Selenic Acid deficiency inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PON1 mRNA]; Selenic Acid deficiency promotes the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of PON1 protein]; Selenic Acid inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PON1 mRNA]
Selenic Acid results in decreased expression of PON1 mRNA
Selenic Acid deficiency results in increased activity of PON1 protein 		CTD PMID:23644946 NCBI chr 4:34,261,312...34,292,327
Ensembl chr 4:34,261,289...34,287,924 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO Selenic Acid results in increased expression of PPARG mRNA CTD PMID:16443359 NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104 		JBrowse link
G Ptger2 prostaglandin E receptor 2 increases expression ISO Selenic Acid results in increased expression of PTGER2 mRNA CTD PMID:16444006 NCBI chr15:20,694,765...20,708,475
Ensembl chr15:20,696,013...20,708,950 		JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 increases expression
decreases activity 		ISO Selenic Acid results in increased expression of PTPN1 mRNA
Selenic Acid results in decreased activity of PTPN1 protein 		CTD PMID:16443359 PMID:22366233 NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:177,057,659...177,106,416 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases phosphorylation ISO Selenic Acid results in increased phosphorylation of RELA protein CTD PMID:21215776 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817 		JBrowse link
G Sod1 superoxide dismutase 1 affects localization
decreases expression 		ISO Selenic Acid affects the localization of SOD1 protein
Selenic Acid results in decreased expression of SOD1 protein 		CTD PMID:21215776 PMID:31585128 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:42,942,678...42,948,399 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression ISO Selenic Acid results in increased expression of SOD2 protein CTD PMID:21215776 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:50,043,325...50,050,168 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 increases activity ISO Selenic Acid results in increased activity of STAT3 protein CTD PMID:22366233 NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359 		JBrowse link
G Tcf7 transcription factor 7 increases expression ISO Selenic Acid results in increased expression of TCF7 mRNA CTD PMID:16444006 NCBI chr10:36,924,363...36,954,279
Ensembl chr10:36,924,363...36,954,279 		JBrowse link
G Tia1 TIA1 cytotoxic granule-associated RNA binding protein multiple interactions ISO Selenic Acid promotes the reaction [TUBA4A protein binds to TIA1 protein] CTD PMID:31585128 NCBI chr 4:120,410,180...120,440,676
Ensembl chr 4:120,410,251...120,440,665 		JBrowse link
G Tuba4a tubulin, alpha 4A multiple interactions
increases glutathionylation 		ISO Selenic Acid promotes the reaction [TUBA4A protein binds to FUS protein]; Selenic Acid promotes the reaction [TUBA4A protein binds to TIA1 protein]
Selenic Acid results in increased glutathionylation of TUBA4A protein 		CTD PMID:31585128 NCBI chr 9:84,158,871...84,174,041
Ensembl chr 9:84,158,280...84,162,584 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases expression ISO Selenic Acid results in increased expression of TXNRD1 protein CTD PMID:31585128 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817 		JBrowse link
G Txnrd2 thioredoxin reductase 2 increases expression ISO Selenic Acid results in increased expression of TXNRD2 protein CTD PMID:31585128 NCBI chr11:96,024,321...96,072,475
Ensembl chr11:96,024,324...96,072,475 		JBrowse link
G Vav2 vav guanine nucleotide exchange factor 2 decreases expression ISO Selenic Acid results in decreased expression of VAV2 mRNA CTD PMID:16444006 NCBI chr 3:30,982,754...31,152,116
Ensembl chr 3:30,982,754...31,152,116 		JBrowse link
selenous acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aqp9 aquaporin 9 increases uptake
multiple interactions 		ISO AQP9 protein results in increased uptake of Selenious Acid
arsenite inhibits the reaction [AQP9 protein results in increased uptake of Selenious Acid]; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone inhibits the reaction [AQP9 protein results in increased uptake of Selenious Acid]; Nigericin inhibits the reaction [AQP9 protein results in increased uptake of Selenious Acid]; Phloretin inhibits the reaction [AQP9 protein results in increased uptake of Selenious Acid] 		CTD PMID:28798983 NCBI chr 8:80,678,027...80,718,273
Ensembl chr 8:80,678,030...80,717,240 		JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 multiple interactions ISO Selenious Acid inhibits the reaction [Dexamethasone binds to NR3C1 protein] CTD PMID:2298732 NCBI chr18:31,522,783...31,644,508
Ensembl chr18:31,522,783...31,643,843 		JBrowse link
G Slc4a1 solute carrier family 4 member 1 (Diego blood group) increases uptake ISO SLC4A1 protein results in increased uptake of Selenious Acid CTD PMID:32652143 NCBI chr10:87,807,010...87,823,274
Ensembl chr10:87,807,013...87,823,258 		JBrowse link
G Txnrd1 thioredoxin reductase 1 increases activity ISO Selenious Acid results in increased activity of TXNRD1 protein CTD PMID:24853413 NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:22,719,317...22,739,817 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20874
    chemical entity 20872
      atom 20872
        nonmetal atom 20781
          selenium atom 3305
            selenium molecular entity 3305
              selenium oxoacid 34
                selenic acid + 32
                seleninic acid 0
                selenonic acid 0
                selenous acid 4
Path 2
Term Annotations click to browse term
  CHEBI ontology 20874
    subatomic particle 20883
      composite particle 20883
        hadron 20872
          baryon 20883
            nucleon 20872
              atomic nucleus 20883
                atom 20872
                  main group element atom 20796
                    p-block element atom 20796
                      chalcogen 20489
                        oxygen atom 20437
                          oxygen molecular entity 20437
                            hydroxides 19922
                              oxoacid 17853
                                chalcogen oxoacid 34
                                  selenium oxoacid 34
                                    selenic acid + 32
                                    seleninic acid 0
                                    selenonic acid 0
                                    selenous acid 4
paths to the root