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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Candesartan cilexetil
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Accession:CHEBI:3348 term browser browse the term
Definition:A biphenyl that has formula C33H34N6O6.
Synonyms:related_synonym: Formula=C33H34N6O6;   InChI=1S/C33H34N6O6/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38);   InChIKey=GHOSNRCGJFBJIB-UHFFFAOYSA-N;   SMILES=CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1;   TCV-116
 xref: CAS:145040-37-5;   Drug_Central:475;   KEGG:C07709;   KEGG:D00626;   LINCS:LSM-1716
 xref_mesh: MESH:C077793


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Candesartan cilexetil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ace2 angiotensin I converting enzyme 2 increases expression EXP candesartan cilexetil results in increased expression of ACE2 protein CTD PMID:22120037 NCBI chr  X:32,050,734...32,095,860
Ensembl chr  X:32,049,931...32,096,016
JBrowse link
G Agt angiotensinogen decreases activity
multiple interactions
increases expression
ISO
EXP
candesartan cilexetil results in decreased activity of AGT protein
candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of AGT protein modified form]
candesartan cilexetil results in increased expression of AGT protein modified form
candesartan cilexetil inhibits the reaction [AGT protein results in increased expression of ICAM1 mRNA]; candesartan cilexetil inhibits the reaction [AGT protein results in increased secretion of ICAM1 protein]
CTD PMID:10517737 PMID:15361886 PMID:22120037 PMID:27889505 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Agtr1a angiotensin II receptor, type 1a multiple interactions EXP candesartan cilexetil binds to and results in decreased activity of AGTR1A protein CTD PMID:15667801 NCBI chr17:35,907,102...35,958,136
Ensembl chr17:35,907,108...35,958,077
JBrowse link
G Agtr2 angiotensin II receptor, type 2 increases expression EXP candesartan cilexetil results in increased expression of AGTR2 protein CTD PMID:22120037 NCBI chr  X:119,389,480...119,393,845
Ensembl chr  X:119,390,013...119,393,842
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression EXP candesartan cilexetil results in increased expression of ATP2A2 protein CTD PMID:22120037 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Bcl2 BCL2, apoptosis regulator increases expression EXP candesartan cilexetil results in increased expression of BCL2 protein CTD PMID:22120037 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 increases expression EXP candesartan cilexetil results in increased expression of BCL2L1 protein CTD PMID:22120037 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions EXP candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of CCN2 protein] CTD PMID:27889505 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions EXP candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of COL3A1 protein] CTD PMID:27889505 NCBI chr 9:52,023,295...52,059,221
Ensembl chr 9:52,023,295...52,059,217
JBrowse link
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 decreases expression EXP candesartan cilexetil results in decreased expression of CYP11B2 mRNA CTD PMID:11086231 NCBI chr 7:116,155,928...116,161,781
Ensembl chr 7:116,156,219...116,255,167
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO candesartan cilexetil results in decreased activity of CYP2C8 protein CTD PMID:15601807 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Edn1 endothelin 1 multiple interactions EXP candesartan cilexetil inhibits the reaction [Mercuric Chloride results in increased expression of EDN1 mRNA] CTD PMID:9853001 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 decreases expression EXP candesartan cilexetil results in decreased expression of ERN1 protein CTD PMID:22120037 NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 decreases expression EXP candesartan cilexetil results in decreased expression of HSPA5 protein CTD PMID:22120037 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO candesartan cilexetil inhibits the reaction [AGT protein results in increased expression of ICAM1 mRNA]; candesartan cilexetil inhibits the reaction [AGT protein results in increased secretion of ICAM1 protein] CTD PMID:10517737 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions EXP candesartan cilexetil inhibits the reaction [Isoproterenol results in increased expression of IGF1 mRNA]; candesartan cilexetil inhibits the reaction [Isoproterenol results in increased expression of IGF1 protein] CTD PMID:10547078 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Mas1 MAS1 proto-oncogene, G protein-coupled receptor increases expression EXP candesartan cilexetil results in increased expression of MAS1 protein CTD PMID:22120037 NCBI chr 1:48,076,761...48,108,218
Ensembl chr 1:48,077,033...48,108,216
JBrowse link
G Mfn2 mitofusin 2 increases expression EXP candesartan cilexetil results in increased expression of MFN2 mRNA; candesartan cilexetil results in increased expression of MFN2 protein CTD PMID:25464244 PMID:27085127 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Myh7 myosin heavy chain 7 decreases expression EXP candesartan cilexetil results in decreased expression of MYH7 mRNA CTD PMID:15667801 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Nos1 nitric oxide synthase 1 increases expression EXP candesartan cilexetil results in increased expression of NOS1 mRNA CTD PMID:7533141 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP candesartan cilexetil inhibits the reaction [Mercuric Chloride results in increased expression of NOS2 mRNA] CTD PMID:9853001 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP candesartan cilexetil results in increased expression of NOS3 mRNA CTD PMID:18551021 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nppb natriuretic peptide B decreases expression EXP candesartan cilexetil results in decreased expression of NPPB mRNA CTD PMID:15667801 NCBI chr 5:164,796,176...164,797,538
Ensembl chr 5:164,796,185...164,797,531
JBrowse link
G Slc22a25 solute carrier family 22, member 25 multiple interactions ISO candesartan cilexetil inhibits the reaction [SLC22A9 protein results in increased uptake of estrone sulfate] CTD PMID:17132213 NCBI chr 1:224,596,886...224,698,512
Ensembl chr 1:224,596,887...224,698,514
JBrowse link
G Smad3 SMAD family member 3 multiple interactions EXP candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of SMAD3 protein modified form] CTD PMID:27889505 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
JBrowse link
G Smad4 SMAD family member 4 multiple interactions EXP candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of SMAD4 protein] CTD PMID:27889505 NCBI chr18:69,626,682...69,657,373
Ensembl chr18:69,627,757...69,671,199
JBrowse link
G Sod2 superoxide dismutase 2 decreases activity EXP candesartan cilexetil results in decreased activity of SOD2 protein CTD PMID:27085127 NCBI chr 1:47,914,757...47,921,587
Ensembl chr 1:47,914,759...47,921,587
JBrowse link
G Tgfb1 transforming growth factor, beta 1 decreases expression EXP candesartan cilexetil results in decreased expression of TGFB1 mRNA CTD PMID:15667801 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 multiple interactions EXP candesartan cilexetil inhibits the reaction [sodium arsenite results in increased expression of TGFBR2 protein] CTD PMID:27889505 NCBI chr 8:124,310,288...124,399,345
Ensembl chr 8:124,312,754...124,399,494
JBrowse link
G Traf2 Tnf receptor-associated factor 2 decreases expression EXP candesartan cilexetil results in decreased expression of TRAF2 protein CTD PMID:22120037 NCBI chr 3:2,746,061...2,770,690
Ensembl chr 3:2,746,075...2,770,620
JBrowse link

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Term Annotations click to browse term
  CHEBI ontology 19767
    chemical entity 19767
      molecular entity 19766
        polyatomic entity 19685
          molecule 19526
            cyclic compound 19359
              ring assembly 7264
                biphenyls 6009
                  Candesartan cilexetil 30
Path 2
Term Annotations click to browse term
  CHEBI ontology 19767
    subatomic particle 19766
      composite particle 19766
        hadron 19766
          baryon 19766
            nucleon 19766
              atomic nucleus 19766
                atom 19766
                  main group element atom 19657
                    p-block element atom 19657
                      carbon group element atom 19573
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19496
                              organic cyclic compound 19322
                                carbocyclic compound 18299
                                  benzenoid aromatic compound 17404
                                    biphenyls 6009
                                      Candesartan cilexetil 30
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