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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:organoheteryl group
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Accession:CHEBI:33456 term browser browse the term
Definition:A univalent group containing carbon which has its free valence at an atom other than carbon.
Synonyms:exact_synonym: organoheteryl groups
 related_synonym: groupe organoheteryle;   grupo organoheterilo;   grupos organoheterilo;   organoelement group



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thioridazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AP1S1 adaptor related protein complex 1 subunit sigma 1 decreases expression EXP Thioridazine results in decreased expression of AP1S1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 7:101,154,476...101,161,276
Ensembl chr 7:101,154,456...101,161,596
JBrowse link
G ASAH1 N-acylsphingosine amidohydrolase 1 increases expression EXP Thioridazine results in increased expression of ASAH1 mRNA CTD PMID:17175557 NCBI chr 8:18,055,992...18,084,961
Ensembl chr 8:18,055,992...18,084,998
JBrowse link
G ASNS asparagine synthetase (glutamine-hydrolyzing) increases expression EXP Thioridazine results in increased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 7:97,851,677...97,928,441
Ensembl chr 7:97,851,677...97,872,542
JBrowse link
G CASP3 caspase 3 increases activity EXP Thioridazine results in increased activity of CASP3 protein CTD PMID:21035837 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062
JBrowse link
G CCND1 cyclin D1 decreases expression EXP Thioridazine results in decreased expression of CCND1 protein CTD PMID:21035837 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474
JBrowse link
G CDC25A cell division cycle 25A increases phosphorylation EXP Thioridazine results in increased phosphorylation of CDC25A protein CTD PMID:21035837 NCBI chr 3:48,157,146...48,188,417
Ensembl chr 3:48,157,146...48,188,417
JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP Thioridazine results in decreased expression of CDK4 protein CTD PMID:21035837 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013
JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP Thioridazine results in increased expression of CDKN1A protein CTD PMID:21035837 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337
JBrowse link
G CDKN2A cyclin dependent kinase inhibitor 2A increases expression EXP Thioridazine results in increased expression of CDKN2A protein CTD PMID:21035837 NCBI chr 9:21,967,752...21,995,324
Ensembl chr 9:21,967,752...21,995,301
JBrowse link
G CES1 carboxylesterase 1 multiple interactions EXP Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate] CTD PMID:20097249 NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337
JBrowse link
G CRH corticotropin releasing hormone decreases expression EXP Thioridazine results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 8:66,176,376...66,178,464
Ensembl chr 8:66,176,376...66,178,464
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 multiple interactions EXP [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP1A2 protein results in increased metabolism of and results in increased activity of Thioridazine CTD PMID:19482014 PMID:23397584 NCBI chr15:74,748,845...74,756,607
Ensembl chr15:74,748,845...74,756,607
JBrowse link
G CYP2A6 cytochrome P450 family 2 subfamily A member 6 decreases activity EXP Thioridazine results in decreased activity of CYP2A6 protein CTD PMID:15135088 NCBI chr19:40,843,541...40,850,447
Ensembl chr19:40,843,541...40,850,447
JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity
multiple interactions
EXP Thioridazine results in decreased activity of CYP2C19 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine
CTD PMID:15135088 PMID:23397584 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547
JBrowse link
G CYP2C9 cytochrome P450 family 2 subfamily C member 9 decreases activity
multiple interactions
EXP Thioridazine results in decreased activity of CYP2C9 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine
CTD PMID:15135088 PMID:23397584 NCBI chr10:94,938,658...94,990,091
Ensembl chr10:94,938,658...94,990,091
JBrowse link
G CYP2D6 cytochrome P450 family 2 subfamily D member 6 multiple interactions EXP [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP2D6 protein results in increased metabolism of and results in increased activity of Thioridazine CTD PMID:19482014 PMID:23397584 NCBI chr22:42,126,499...42,130,810
Ensembl chr22:42,126,499...42,130,865
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases activity EXP Thioridazine results in decreased activity of CYP2E1 protein CTD PMID:15135088 NCBI chr10:133,527,363...133,539,123
Ensembl chr10:133,520,406...133,561,220
JBrowse link
G CYP3A4 cytochrome P450 family 3 subfamily A member 4 decreases activity
multiple interactions
EXP Thioridazine results in decreased activity of CYP3A4 protein
[CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine
CTD PMID:15135088 PMID:23397584 NCBI chr 7:99,756,967...99,784,184
Ensembl chr 7:99,756,960...99,784,248
JBrowse link
G DEPP1 DEPP autophagy regulator 1 increases expression EXP Thioridazine results in increased expression of DEPP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr10:44,976,128...44,978,809
Ensembl chr10:44,970,981...44,978,809
JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation EXP Thioridazine results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:21035837 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365
JBrowse link
G FABP1 fatty acid binding protein 1 increases expression EXP Thioridazine results in increased expression of FABP1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 2:88,122,982...88,128,062
Ensembl chr 2:88,122,982...88,128,062
JBrowse link
G FNDC4 fibronectin type III domain containing 4 increases expression EXP Thioridazine results in increased expression of FNDC4 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr 2:27,491,883...27,495,200
Ensembl chr 2:27,491,883...27,495,200
JBrowse link
G GDPD3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression EXP Thioridazine results in increased expression of GDPD3 mRNA CTD PMID:17175557 NCBI chr16:30,104,810...30,113,537
Ensembl chr16:30,104,810...30,113,537
JBrowse link
G HPN hepsin increases expression EXP Thioridazine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr19:35,040,506...35,066,573
Ensembl chr19:35,040,506...35,066,573
JBrowse link
G INHBE inhibin subunit beta E increases expression EXP Thioridazine results in increased expression of INHBE mRNA CTD PMID:15342952 PMID:17175557 NCBI chr12:57,455,307...57,458,025
Ensembl chr12:57,452,323...57,459,280
JBrowse link
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
EXP Thioridazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Thioridazine results in decreased activity of KCNH2 protein
CTD PMID:15671647 PMID:16278312 PMID:21158687 PMID:24052561 NCBI chr 7:150,944,961...150,978,321
Ensembl chr 7:150,944,961...150,978,321
JBrowse link
G LSS lanosterol synthase increases expression EXP Thioridazine results in increased expression of LSS mRNA CTD PMID:15342952 PMID:17175557 NCBI chr21:46,188,446...46,228,774
Ensembl chr21:46,188,141...46,228,824
JBrowse link
G NR0B2 nuclear receptor subfamily 0 group B member 2 increases expression EXP Thioridazine results in increased expression of NR0B2 mRNA CTD PMID:17175557 NCBI chr 1:26,911,489...26,913,975
Ensembl chr 1:26,911,489...26,913,975
JBrowse link
G NUPR1 nuclear protein 1, transcriptional regulator increases expression EXP Thioridazine results in increased expression of NUPR1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr16:28,532,708...28,538,974
Ensembl chr16:28,532,708...28,539,008
JBrowse link
G PHYH phytanoyl-CoA 2-hydroxylase increases expression EXP Thioridazine results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr10:13,277,799...13,300,064
Ensembl chr10:13,277,796...13,302,412
JBrowse link
G PRL prolactin increases expression EXP Thioridazine results in increased expression of PRL protein CTD PMID:4065553 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826
JBrowse link
G SERPINA3 serpin family A member 3 increases expression EXP Thioridazine results in increased expression of SERPINA3 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr14:94,612,391...94,624,053
Ensembl chr14:94,612,384...94,624,055
JBrowse link
G SLC22A2 solute carrier family 22 member 2 multiple interactions EXP Thioridazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 6:160,216,755...160,258,821
Ensembl chr 6:160,171,061...160,277,638
JBrowse link
G SLC2A3 solute carrier family 2 member 3 decreases expression EXP Thioridazine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr12:7,919,230...7,936,187
Ensembl chr12:7,919,230...8,019,007
JBrowse link
G TAGLN transgelin decreases expression EXP Thioridazine results in decreased expression of TAGLN mRNA CTD PMID:15342952 PMID:17175557 NCBI chr11:117,199,294...117,207,465
Ensembl chr11:117,199,370...117,207,464
JBrowse link
G TP53 tumor protein p53 affects activity EXP Thioridazine affects the activity of TP53 protein CTD PMID:35435491 NCBI chr17:7,668,421...7,687,490
Ensembl chr17:7,661,779...7,687,546
JBrowse link
G WIPI1 WD repeat domain, phosphoinositide interacting 1 increases expression EXP Thioridazine results in increased expression of WIPI1 mRNA CTD PMID:15342952 PMID:17175557 NCBI chr17:68,421,281...68,457,496
Ensembl chr17:68,420,948...68,457,513
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26429
    chemical entity 26409
      group 26269
        organic group 23748
          organic univalent group 22817
            organoheteryl group 37
              (C-hydroxycarbonimidoyl)amino group 0
              (p-hydroxyphenyl)glycinamido group 0
              2-(aminomethylidene)hydrazinyl group 0
              4-arsonophenyldiazenyl group 0
              C-aminocarbonohydrazonoyl group 0
              C-terminal L-Ala-L-Leu-L-valinamide-N-CH=CH-S residue 0
              L-homoserine lactone group 0
              N-oxindolyl group 0
              O-(N-acetyl-alpha-D-galactosaminyl)-L-threonino group 0
              \{5-[(3-azidopropyl)amino]-5-oxopentanoyl\}amino group 0
              acetimidamido group 0
              acetimidoyl group 0
              acetylhydrazino group 0
              alkylamino group + 0
              alkyloxy group + 0
              benzoyloxy group 0
              benzyloxy group + 0
              carbamothioyl group 0
              carbamoylamino group 0
              carbamoylcarbamoyl group 0
              cyanato group 0
              guanidino group + 0
              methylsulfanyl group + 37
              organosilyl group + 0
              oxaloamino group 0
              oxalooxy group 0
              oxalosulfanyl group 0
              oxamoyl group 0
              oxamoylamino group 0
              phenylazo groups + 0
              phenylsulfanyl group + 0
              quininyl group 0
              thiocyanato group 0
              triflate group + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26429
    subatomic particle 26405
      composite particle 26405
        hadron 26405
          baryon 26405
            nucleon 26405
              atomic nucleus 26405
                atom 26405
                  group 26269
                    organic group 23748
                      organic univalent group 22817
                        organoheteryl group 37
                          (C-hydroxycarbonimidoyl)amino group 0
                          (p-hydroxyphenyl)glycinamido group 0
                          2-(aminomethylidene)hydrazinyl group 0
                          4-arsonophenyldiazenyl group 0
                          C-aminocarbonohydrazonoyl group 0
                          C-terminal L-Ala-L-Leu-L-valinamide-N-CH=CH-S residue 0
                          L-homoserine lactone group 0
                          N-oxindolyl group 0
                          O-(N-acetyl-alpha-D-galactosaminyl)-L-threonino group 0
                          \{5-[(3-azidopropyl)amino]-5-oxopentanoyl\}amino group 0
                          acetimidamido group 0
                          acetimidoyl group 0
                          acetylhydrazino group 0
                          alkylamino group + 0
                          alkyloxy group + 0
                          benzoyloxy group 0
                          benzyloxy group + 0
                          carbamothioyl group 0
                          carbamoylamino group 0
                          carbamoylcarbamoyl group 0
                          cyanato group 0
                          guanidino group + 0
                          methylsulfanyl group + 37
                          organosilyl group + 0
                          oxaloamino group 0
                          oxalooxy group 0
                          oxalosulfanyl group 0
                          oxamoyl group 0
                          oxamoylamino group 0
                          phenylazo groups + 0
                          phenylsulfanyl group + 0
                          quininyl group 0
                          thiocyanato group 0
                          triflate group + 0
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