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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:organoheteryl group
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Accession:CHEBI:33456 term browser browse the term
Definition:A univalent group containing carbon which has its free valence at an atom other than carbon.
Synonyms:exact_synonym: organoheteryl groups
 related_synonym: groupe organoheteryle;   grupo organoheterilo;   grupos organoheterilo;   organoelement group


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thioridazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ap1s1 adaptor related protein complex 1 subunit sigma 1 decreases expression ISO Thioridazine results in decreased expression of AP1S1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr12:22,665,128...22,676,079
Ensembl chr12:22,665,112...22,676,075
JBrowse link
G Asah1 N-acylsphingosine amidohydrolase 1 increases expression ISO Thioridazine results in increased expression of ASAH1 mRNA CTD PMID:17175557 NCBI chr16:53,998,604...54,030,006
Ensembl chr16:53,998,560...54,040,836
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO Thioridazine results in increased expression of ASNS mRNA CTD PMID:17175557 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Casp3 caspase 3 increases activity ISO Thioridazine results in increased activity of CASP3 protein CTD PMID:21035837 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO Thioridazine results in decreased expression of CCND1 protein CTD PMID:21035837 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Cdc25a cell division cycle 25A increases phosphorylation ISO Thioridazine results in increased phosphorylation of CDC25A protein CTD PMID:21035837 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO Thioridazine results in decreased expression of CDK4 protein CTD PMID:21035837 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO Thioridazine results in increased expression of CDKN1A protein CTD PMID:21035837 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO Thioridazine results in increased expression of CDKN2A protein CTD PMID:21035837 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
JBrowse link
G Ces1d carboxylesterase 1D multiple interactions ISO Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of 4-nitrophenyl acetate]; Thioridazine inhibits the reaction [CES1 protein results in increased hydrolysis of Methylphenidate] CTD PMID:20097249 NCBI chr19:15,195,514...15,239,827
Ensembl chr19:15,033,108...15,239,821
JBrowse link
G Crh corticotropin releasing hormone decreases expression ISO Thioridazine results in decreased expression of CRH mRNA CTD PMID:16205782 NCBI chr 2:104,459,999...104,461,863
Ensembl chr 2:104,459,999...104,461,863
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP1A2 protein results in increased metabolism of and results in increased activity of Thioridazine CTD PMID:19482014, PMID:23397584 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 multiple interactions
decreases activity
ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine
Thioridazine results in decreased activity of CYP2C19 protein
CTD PMID:15135088, PMID:23397584 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions ISO [CYP1A2 protein co-treated with CYP2C9 protein co-treated with CYP3A4 protein co-treated with CYP2D6 protein co-treated with CYP2C19 protein] affects the susceptibility to Thioridazine; CYP2D6 protein results in increased metabolism of and results in increased activity of Thioridazine CTD PMID:19482014, PMID:23397584 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO Thioridazine results in decreased activity of CYP2E1 protein CTD PMID:15135088 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Depp1 DEPP1, autophagy regulator increases expression ISO Thioridazine results in increased expression of DEPP1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 4:148,780,330...148,784,566
Ensembl chr 4:148,782,479...148,784,562
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation ISO Thioridazine results in decreased phosphorylation of EIF4EBP1 protein CTD PMID:21035837 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Fabp1 fatty acid binding protein 1 increases expression ISO Thioridazine results in increased expression of FABP1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 4:99,063,181...99,066,957
Ensembl chr 4:99,063,181...99,066,954
JBrowse link
G Gdpd3 glycerophosphodiester phosphodiesterase domain containing 3 increases expression ISO Thioridazine results in increased expression of GDPD3 mRNA CTD PMID:17175557 NCBI chr 1:198,199,032...198,209,178
Ensembl chr 1:198,199,622...198,209,150
JBrowse link
G Hpn hepsin increases expression ISO Thioridazine results in increased expression of HPN mRNA CTD PMID:15342952 NCBI chr 1:89,534,112...89,549,575
Ensembl chr 1:89,534,106...89,543,967
JBrowse link
G Inhbe inhibin subunit beta E increases expression ISO Thioridazine results in increased expression of INHBE mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 7:70,641,423...70,642,848
Ensembl chr 7:70,640,075...70,643,169
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 multiple interactions
decreases activity
ISO Thioridazine inhibits the reaction [KCNH2 protein results in increased transport of Thallium]
Thioridazine results in decreased activity of KCNH2 protein
CTD PMID:15671647, PMID:16278312, PMID:21158687, PMID:24052561 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
JBrowse link
G Lss lanosterol synthase increases expression ISO Thioridazine results in increased expression of LSS mRNA CTD PMID:15342952, PMID:17175557 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Thioridazine results in increased expression of NR0B2 mRNA CTD PMID:17175557 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression ISO Thioridazine results in increased expression of NUPR1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Phyh phytanoyl-CoA 2-hydroxylase increases expression ISO Thioridazine results in increased expression of PHYH mRNA CTD PMID:15342952 NCBI chr17:77,287,580...77,304,482
Ensembl chr17:77,287,188...77,304,530
JBrowse link
G Prl prolactin increases expression ISO Thioridazine results in increased expression of PRL protein CTD PMID:4065553 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Serpina3m serpin family A member 3M increases expression ISO Thioridazine results in increased expression of SERPINA3 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 6:127,808,785...127,816,067
Ensembl chr 6:127,808,785...127,816,055
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Thioridazine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium] CTD PMID:21599003 NCBI chr 1:48,318,025...48,360,219
Ensembl chr 1:48,317,995...48,360,261
JBrowse link
G Slc2a3 solute carrier family 2 member 3 decreases expression ISO Thioridazine results in decreased expression of SLC2A3 mRNA CTD PMID:15342952 NCBI chr 4:155,549,991...155,626,018
Ensembl chr 4:155,408,233...155,631,856
JBrowse link
G Tagln transgelin decreases expression ISO Thioridazine results in decreased expression of TAGLN mRNA CTD PMID:15342952, PMID:17175557 NCBI chr 8:50,222,895...50,228,369
Ensembl chr 8:50,222,896...50,231,357
JBrowse link
G Wipi1 WD repeat domain, phosphoinositide interacting 1 increases expression ISO Thioridazine results in increased expression of WIPI1 mRNA CTD PMID:15342952, PMID:17175557 NCBI chr10:97,859,730...97,896,949
Ensembl chr10:97,859,727...97,896,525
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    chemical entity 19785
      group 19696
        organic group 18493
          organic univalent group 18067
            organoheteryl group 32
              (C-hydroxycarbonimidoyl)amino group 0
              (p-hydroxyphenyl)glycinamido group 0
              2-(aminomethylidene)hydrazinyl group 0
              4-arsonophenyldiazenyl group 0
              C-aminocarbonohydrazonoyl group 0
              C-terminal L-Ala-L-Leu-L-valinamide-N-CH=CH-S residue 0
              L-homoserine lactone group 0
              N-oxindolyl group 0
              O-(N-acetyl-alpha-D-galactosaminyl)-L-threonino group 0
              \{5-[(3-azidopropyl)amino]-5-oxopentanoyl\}amino group 0
              acetimidamido group 0
              acetimidoyl group 0
              acetylhydrazino group 0
              alkylamino group + 0
              alkyloxy group + 0
              benzoyloxy group 0
              benzyloxy group + 0
              carbamothioyl group 0
              carbamoylamino group 0
              carbamoylcarbamoyl group 0
              cyanato group 0
              guanidino group + 0
              methylsulfanyl group + 32
              organosilyl group + 0
              oxaloamino group 0
              oxalooxy group 0
              oxalosulfanyl group 0
              oxamoyl group 0
              oxamoylamino group 0
              phenylazo groups + 0
              phenylsulfanyl group + 0
              quininyl group 0
              thiocyanato group 0
              triflate group + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon group molecular entity 19572
                          organic molecular entity 19561
                            organic group 18493
                              organic univalent group 18067
                                organoheteryl group 32
                                  (C-hydroxycarbonimidoyl)amino group 0
                                  (p-hydroxyphenyl)glycinamido group 0
                                  2-(aminomethylidene)hydrazinyl group 0
                                  4-arsonophenyldiazenyl group 0
                                  C-aminocarbonohydrazonoyl group 0
                                  C-terminal L-Ala-L-Leu-L-valinamide-N-CH=CH-S residue 0
                                  L-homoserine lactone group 0
                                  N-oxindolyl group 0
                                  O-(N-acetyl-alpha-D-galactosaminyl)-L-threonino group 0
                                  \{5-[(3-azidopropyl)amino]-5-oxopentanoyl\}amino group 0
                                  acetimidamido group 0
                                  acetimidoyl group 0
                                  acetylhydrazino group 0
                                  alkylamino group + 0
                                  alkyloxy group + 0
                                  benzoyloxy group 0
                                  benzyloxy group + 0
                                  carbamothioyl group 0
                                  carbamoylamino group 0
                                  carbamoylcarbamoyl group 0
                                  cyanato group 0
                                  guanidino group + 0
                                  methylsulfanyl group + 32
                                  organosilyl group + 0
                                  oxaloamino group 0
                                  oxalooxy group 0
                                  oxalosulfanyl group 0
                                  oxamoyl group 0
                                  oxamoylamino group 0
                                  phenylazo groups + 0
                                  phenylsulfanyl group + 0
                                  quininyl group 0
                                  thiocyanato group 0
                                  triflate group + 0
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