CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: chlorine oxoanion
Accession: CHEBI:33437
browse the term
Synonyms: related_synonym: chlorine oxoanions
cyclic_relationship: is_conjugate_base_of CHEBI:33426
G
Ache
acetylcholinesterase
increases activity
ISO
chlorite results in increased activity of ACHE protein
CTD
PMID:27478981
NCBI chr 5:137,286,516...137,292,728
Ensembl chr 5:137,285,781...137,292,728
G
Cat
catalase
decreases activity
ISO
chlorite results in decreased activity of CAT protein
CTD
PMID:27478981
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
G
G6pdx
glucose-6-phosphate dehydrogenase X-linked
decreases activity
ISO
chlorite results in decreased activity of G6PD protein
CTD
PMID:27478981
NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800
G
Gsr
glutathione reductase
decreases activity
ISO
chlorite results in decreased activity of GSR protein
CTD
PMID:27478981
NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
G
H2ax
H2A.X variant histone
multiple interactions
ISO
chlorite promotes the reaction [Bromates results in increased phosphorylation of H2AX protein]
CTD
PMID:21864635
NCBI chr 9:44,246,012...44,247,374
Ensembl chr 9:44,245,991...44,247,374
G
Ldhb
lactate dehydrogenase B
increases activity
ISO
chlorite results in increased activity of LDHB protein
CTD
PMID:27478981
NCBI chr 6:142,435,975...142,453,683
Ensembl chr 6:142,435,975...142,453,683
G
Sod1
superoxide dismutase 1, soluble
increases activity
ISO
chlorite results in increased activity of SOD1 protein
CTD
PMID:27478981
NCBI chr16:90,017,650...90,023,221
Ensembl chr16:90,017,642...90,023,217
G
Txnrd1
thioredoxin reductase 1
decreases activity
ISO
chlorite results in decreased activity of TXNRD1 protein
CTD
PMID:27478981
NCBI chr10:82,669,785...82,733,558
Ensembl chr10:82,669,785...82,733,546
G
Aqp1
aquaporin 1
affects expression
ISO
perchlorate affects the expression of AQP1 mRNA
CTD
PMID:21623536
NCBI chr 6:55,313,284...55,325,540
Ensembl chr 6:55,313,417...55,325,540
G
Bdnf
brain derived neurotrophic factor
decreases expression
ISO
perchlorate results in decreased expression of BDNF mRNA
CTD
PMID:35385113
NCBI chr 2:109,505,045...109,557,388
Ensembl chr 2:109,505,045...109,557,352
G
Bmp7
bone morphogenetic protein 7
decreases expression
ISO
perchlorate results in decreased expression of BMP7 mRNA
CTD
PMID:35385113
NCBI chr 2:172,709,805...172,782,114
Ensembl chr 2:172,709,805...172,782,114
G
Camk4
calcium/calmodulin-dependent protein kinase IV
decreases expression
ISO
perchlorate results in decreased expression of CAMK4 mRNA
CTD
PMID:35385113
NCBI chr18:33,067,995...33,328,820
Ensembl chr18:33,067,984...33,324,281
G
Car1
carbonic anhydrase 1
decreases activity
ISO
perchlorate results in decreased activity of CA1 protein
CTD
PMID:15664814
NCBI chr 3:14,831,274...14,873,425
Ensembl chr 3:14,831,276...14,873,428
G
Car2
carbonic anhydrase 2
decreases activity
ISO
perchlorate results in decreased activity of CA2 protein
CTD
PMID:15664814
NCBI chr 3:14,951,329...14,965,830
Ensembl chr 3:14,951,333...14,965,830
G
Car5a
carbonic anhydrase 5a, mitochondrial
decreases activity
ISO
perchlorate results in decreased activity of CA5A protein
CTD
PMID:15664814
NCBI chr 8:122,642,874...122,671,651
Ensembl chr 8:122,642,865...122,671,643
G
Car9
carbonic anhydrase 9
decreases activity
ISO
perchlorate results in decreased activity of CA9 protein
CTD
PMID:15664814
NCBI chr 4:43,507,026...43,513,729
Ensembl chr 4:43,506,966...43,513,729
G
Casp3
caspase 3
increases activity multiple interactions
ISO
perchlorate results in increased activity of CASP3 protein Sodium Iodide promotes the reaction [perchlorate results in increased activity of CASP3 protein]
CTD
PMID:11834455
NCBI chr 8:47,070,326...47,092,733
Ensembl chr 8:47,070,326...47,092,724
G
Fos
FBJ osteosarcoma oncogene
multiple interactions
ISO
[sodium perchlorate results in increased abundance of perchlorate] which results in increased expression of FOS protein
CTD
PMID:30991129
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
G
Mir133a-1
microRNA 133a-1
multiple interactions
EXP
[Methimazole co-treated with perchlorate] results in increased expression of MIR133A1 mRNA
CTD
PMID:20808432
NCBI chr18:10,782,909...10,782,976
Ensembl chr18:10,782,909...10,782,976
G
Mir133b
microRNA 133b
multiple interactions
EXP
[Methimazole co-treated with perchlorate] results in increased expression of MIR133B mRNA
CTD
PMID:20808432
NCBI chr 1:20,752,993...20,753,111
Ensembl chr 1:20,752,993...20,753,111
G
Mir135a-2
microRNA 135a-2
multiple interactions
EXP
[Methimazole co-treated with perchlorate] results in increased expression of MIR135A mRNA
CTD
PMID:20808432
NCBI chr10:91,907,948...91,908,047
Ensembl chr10:91,907,948...91,908,047
G
Mir135b
microRNA 135b
multiple interactions
EXP
[Methimazole co-treated with perchlorate] results in increased expression of MIR135B mRNA
CTD
PMID:20808432
NCBI chr 1:132,125,826...132,125,922
Ensembl chr 1:132,125,826...132,125,922
G
Mir148a
microRNA 148a
multiple interactions
EXP
[Methimazole co-treated with perchlorate] results in decreased expression of MIR148A mRNA
CTD
PMID:20808432
NCBI chr 6:51,246,792...51,246,890
Ensembl chr 6:51,246,792...51,246,890
G
Mir199b
microRNA 199b
multiple interactions
EXP
[Methimazole co-treated with perchlorate] results in increased expression of MIR199B mRNA
CTD
PMID:20808432
NCBI chr 2:32,208,472...32,208,581
Ensembl chr 2:32,208,472...32,208,581
G
Mir206
microRNA 206
multiple interactions
EXP
[Methimazole co-treated with perchlorate] results in increased expression of MIR206 mRNA
CTD
PMID:20808432
NCBI chr 1:20,749,234...20,749,306
Ensembl chr 1:20,749,234...20,749,306
G
Papss1
3'-phosphoadenosine 5'-phosphosulfate synthase 1
multiple interactions
ISO
perchlorate binds to and results in decreased activity of PAPSS1 protein
CTD
PMID:15065880
NCBI chr 3:131,270,626...131,349,432
Ensembl chr 3:131,270,529...131,349,432
G
Pax8
paired box 8
decreases expression
ISO
perchlorate results in decreased expression of PAX8 mRNA
CTD
PMID:35385113
NCBI chr 2:24,310,563...24,365,611
Ensembl chr 2:24,310,572...24,365,611
G
Slc22a3
solute carrier family 22 (organic cation transporter), member 3
affects expression
ISO
perchlorate affects the expression of SLC22A3 mRNA
CTD
PMID:21623536
NCBI chr17:12,638,859...12,726,591
Ensembl chr17:12,637,847...12,726,591
G
Slc26a4
solute carrier family 26, member 4
increases expression
ISO
perchlorate results in increased expression of SLC26A4 mRNA
CTD
PMID:35385113
NCBI chr12:31,569,813...31,610,054
Ensembl chr12:31,569,826...31,609,968
G
Slc5a5
solute carrier family 5 (sodium iodide symporter), member 5
increases expression affects expression multiple interactions decreases activity
EXP ISO
perchlorate results in increased expression of SLC5A5 protein perchlorate results in increased expression of SLC5A5 mRNA perchlorate affects the expression of SLC5A5 mRNA perchlorate inhibits the reaction [mibolerone promotes the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]]; perchlorate inhibits the reaction [SLC5A5 protein results in increased abundance of Sodium Iodide]; perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodides]; perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide] perchlorate results in decreased activity of SLC5A5 protein
CTD
PMID:12601449 PMID:14633711 PMID:15347726 PMID:15850642 PMID:15941870 PMID:16987991 PMID:17332529 PMID:21623536 PMID:35385113 More...
NCBI chr 8:71,335,529...71,345,429
Ensembl chr 8:71,335,533...71,345,401
G
Tg
thyroglobulin
decreases expression
EXP ISO
perchlorate results in decreased expression of TG protein perchlorate results in decreased expression of TG mRNA
CTD
PMID:17332529 PMID:35385113
NCBI chr15:66,542,606...66,722,570
Ensembl chr15:66,542,602...66,722,570
G
Thrb
thyroid hormone receptor beta
decreases expression
ISO
perchlorate results in decreased expression of THRB mRNA
CTD
PMID:35385113
NCBI chr14:4,429,599...4,810,538
Ensembl chr14:4,431,611...4,809,435
G
Tpo
thyroid peroxidase
increases expression
ISO
perchlorate results in increased expression of TPO mRNA
CTD
PMID:35385113
NCBI chr12:30,104,658...30,182,983
Ensembl chr12:30,104,658...30,182,623
G
Tshb
thyroid stimulating hormone, beta subunit
increases expression multiple interactions
EXP ISO
perchlorate results in increased expression of TSHB protein [Iodides deficiency co-treated with perchlorate] results in increased expression of TSHB protein
CTD
PMID:17332529 PMID:20439182
NCBI chr 3:102,684,621...102,718,175
Ensembl chr 3:102,682,781...102,690,034
G
Tshr
thyroid stimulating hormone receptor
decreases expression
ISO
perchlorate results in decreased expression of TSHR mRNA
CTD
PMID:35385113
NCBI chr12:91,367,767...91,507,283
Ensembl chr12:91,351,337...91,516,582
G
Bmp4
bone morphogenetic protein 4
decreases expression
ISO
sodium chlorate results in decreased expression of BMP4 mRNA
CTD
PMID:12922982
NCBI chr14:46,620,982...46,628,126
Ensembl chr14:46,620,977...46,628,126
G
Cat
catalase
decreases activity
ISO
sodium chlorate results in decreased activity of CAT protein
CTD
PMID:28084674 PMID:30144278
NCBI chr 2:103,284,249...103,315,498
Ensembl chr 2:103,284,194...103,315,505
G
Ccl2
C-C motif chemokine ligand 2
multiple interactions
ISO
sodium chlorate inhibits the reaction [CCL2 protein results in increased activity of CCR2 protein]
CTD
PMID:23408426
NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
G
Ccr2
C-C motif chemokine receptor 2
multiple interactions decreases sulfation
ISO
sodium chlorate inhibits the reaction [CCL2 protein results in increased activity of CCR2 protein] sodium chlorate results in decreased sulfation of CCR2 protein
CTD
PMID:23408426
NCBI chr 9:123,901,954...123,913,594
Ensembl chr 9:123,901,987...123,913,594
G
Fbp1
fructose bisphosphatase 1
decreases activity
ISO
sodium chlorate results in decreased activity of FBP1 protein
CTD
PMID:28084674
NCBI chr13:63,012,567...63,036,112
Ensembl chr13:63,012,567...63,036,096
G
Fgf10
fibroblast growth factor 10
affects activity
EXP
sodium chlorate affects the activity of FGF10 protein
CTD
PMID:12818887
NCBI chr13:118,851,199...118,928,651
Ensembl chr13:118,806,327...118,928,651
G
Fgf23
fibroblast growth factor 23
multiple interactions
ISO
sodium chlorate inhibits the reaction [FGF23 protein results in decreased uptake of Phosphates]
CTD
PMID:27432882
NCBI chr 6:127,049,865...127,059,257
Ensembl chr 6:127,049,865...127,058,371
G
Fshb
follicle stimulating hormone beta
multiple interactions
ISO
sodium chlorate inhibits the reaction [FSHB protein results in increased activity of PDE4A protein]
CTD
PMID:17261351
NCBI chr 2:106,886,331...106,889,996
Ensembl chr 2:106,886,485...106,890,001
G
G6pdx
glucose-6-phosphate dehydrogenase X-linked
decreases activity
ISO
sodium chlorate results in decreased activity of G6PD protein
CTD
PMID:28084674
NCBI chr X:73,453,089...73,472,486
Ensembl chr X:73,453,089...73,472,800
G
Gsr
glutathione reductase
decreases activity
ISO
sodium chlorate results in decreased activity of GSR protein
CTD
PMID:28084674 PMID:30144278
NCBI chr 8:34,143,266...34,188,190
Ensembl chr 8:34,142,551...34,188,191
G
Kl
klotho
decreases expression
ISO
sodium chlorate results in decreased expression of KL protein
CTD
PMID:27432882
NCBI chr 5:150,876,072...150,917,282
Ensembl chr 5:150,876,072...150,917,282
G
Mapk1
mitogen-activated protein kinase 1
decreases phosphorylation multiple interactions
EXP
sodium chlorate results in decreased phosphorylation of MAPK1 protein Heparin inhibits the reaction [sodium chlorate results in decreased phosphorylation of MAPK1 protein]
CTD
PMID:19937756
NCBI chr16:16,801,246...16,865,317
Ensembl chr16:16,801,246...16,865,317
G
Mapk3
mitogen-activated protein kinase 3
multiple interactions decreases phosphorylation
EXP
Heparin inhibits the reaction [sodium chlorate results in decreased phosphorylation of MAPK3 protein]
CTD
PMID:19937756
NCBI chr 7:126,358,798...126,364,988
Ensembl chr 7:126,358,773...126,364,991
G
Nanog
Nanog homeobox
increases expression
EXP
sodium chlorate results in increased expression of NANOG mRNA
CTD
PMID:19937756
NCBI chr 6:122,684,448...122,691,592
Ensembl chr 6:122,684,448...122,691,592
G
Pde4a
phosphodiesterase 4A, cAMP specific
multiple interactions
ISO
sodium chlorate inhibits the reaction [FSHB protein results in increased activity of PDE4A protein]
CTD
PMID:17261351
NCBI chr 9:21,076,998...21,124,544
Ensembl chr 9:21,073,005...21,124,544
G
Sftpc
surfactant associated protein C
decreases expression
ISO
sodium chlorate results in decreased expression of SFTPC mRNA
CTD
PMID:12922982
NCBI chr14:70,758,381...70,761,521
Ensembl chr14:70,758,389...70,761,521
G
Slc5a5
solute carrier family 5 (sodium iodide symporter), member 5
multiple interactions
ISO
sodium chlorate inhibits the reaction [SLC5A5 protein results in increased uptake of perrhenate analog]; sodium chlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; sodium chlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m]
CTD
PMID:12488351
NCBI chr 8:71,335,529...71,345,429
Ensembl chr 8:71,335,533...71,345,401
G
Alpl
alkaline phosphatase, liver/bone/kidney
increases expression
ISO
Sodium Hypochlorite results in increased expression of ALPL mRNA
CTD
PMID:22083529
NCBI chr 4:137,469,042...137,523,695
Ensembl chr 4:137,469,044...137,523,695
G
Atf3
activating transcription factor 3
increases expression
ISO
Sodium Hypochlorite results in increased expression of ATF3 mRNA
CTD
PMID:37149095
NCBI chr 1:190,902,493...190,915,530
Ensembl chr 1:190,902,493...190,950,236
G
Ccl2
C-C motif chemokine ligand 2
decreases expression
ISO
Sodium Hypochlorite results in decreased expression of CCL2 mRNA
CTD
PMID:37149095
NCBI chr11:81,926,403...81,928,278
Ensembl chr11:81,926,397...81,928,279
G
Csrnp1
cysteine-serine-rich nuclear protein 1
increases expression
ISO
Sodium Hypochlorite results in increased expression of CSRNP1 mRNA
CTD
PMID:37149095
NCBI chr 9:119,800,229...119,813,808
Ensembl chr 9:119,800,229...119,813,724
G
Esr2
estrogen receptor 2 (beta)
multiple interactions
ISO
Sodium Hypochlorite inhibits the reaction [bisphenol A binds to ESR2 protein]; Sodium Hypochlorite inhibits the reaction [Estradiol binds to ESR2 protein]; Sodium Hypochlorite inhibits the reaction [nonylphenol binds to ESR2 protein]
CTD
PMID:14723943
NCBI chr12:76,167,193...76,224,033
Ensembl chr12:76,167,193...76,224,033
G
Fosb
FBJ osteosarcoma oncogene B
increases expression
ISO
Sodium Hypochlorite results in increased expression of FOSB mRNA
CTD
PMID:37149095
NCBI chr 7:19,036,621...19,043,970
Ensembl chr 7:19,036,621...19,043,976
G
Gm25279
predicted gene, 25279
decreases expression
ISO
Sodium Hypochlorite results in decreased expression of RNU4-39P
CTD
PMID:37149095
NCBI chr 1:151,730,622...151,730,706
Ensembl chr 1:151,730,574...151,730,706
G
Hmox1
heme oxygenase 1
increases expression
ISO
Sodium Hypochlorite results in increased expression of HMOX1 mRNA
CTD
PMID:37149095
NCBI chr 8:75,820,246...75,827,221
Ensembl chr 8:75,820,249...75,827,217
G
Hsd3b1
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1
decreases expression
ISO
Sodium Hypochlorite results in decreased expression of HSD3B1 mRNA
CTD
PMID:37149095
NCBI chr 3:98,749,672...98,767,110
Ensembl chr 3:98,759,510...98,767,110
G
Hspa1a
heat shock protein 1A
increases expression
ISO
Sodium Hypochlorite results in increased expression of HSPA1A mRNA
CTD
PMID:37149095
NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132
G
Hspa1b
heat shock protein 1B
increases expression
ISO
Sodium Hypochlorite results in increased expression of HSPA1B mRNA
CTD
PMID:37149095
NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214
G
Ifna1
interferon alpha 1
increases expression
ISO
Sodium Hypochlorite results in increased expression of IFNA1 mRNA
CTD
PMID:37149095
NCBI chr 4:88,768,324...88,768,893
Ensembl chr 4:88,768,324...88,768,893
G
Il24
interleukin 24
increases expression
ISO
Sodium Hypochlorite results in increased expression of IL24 mRNA
CTD
PMID:37149095
NCBI chr 1:130,809,801...130,815,153
Ensembl chr 1:130,809,811...130,815,191
G
Junb
jun B proto-oncogene
increases expression
ISO
Sodium Hypochlorite results in increased expression of JUNB mRNA
CTD
PMID:37149095
NCBI chr 8:85,703,538...85,705,377
Ensembl chr 8:85,701,113...85,705,347
G
Mpo
myeloperoxidase
multiple interactions
ISO
Sodium Hypochlorite promotes the reaction [[MPO protein results in increased oxidation of dibromoacetonitrile] which results in increased chemical synthesis of Cyanides]; Sodium Hypochlorite promotes the reaction [MPO protein results in increased oxidation of dibromoacetonitrile]
CTD
PMID:25614581
NCBI chr11:87,684,610...87,695,238
Ensembl chr11:87,684,407...87,695,239
G
Nr4a1
nuclear receptor subfamily 4, group A, member 1
increases expression
ISO
Sodium Hypochlorite results in increased expression of NR4A1 mRNA
CTD
PMID:37149095
NCBI chr15:101,151,783...101,172,676
Ensembl chr15:101,152,150...101,172,676
G
Nr4a2
nuclear receptor subfamily 4, group A, member 2
increases expression
ISO
Sodium Hypochlorite results in increased expression of NR4A2 mRNA
CTD
PMID:37149095
NCBI chr 2:56,996,845...57,014,152
Ensembl chr 2:56,996,842...57,014,015
G
Nr4a3
nuclear receptor subfamily 4, group A, member 3
increases expression
ISO
Sodium Hypochlorite results in increased expression of NR4A3 mRNA
CTD
PMID:37149095
NCBI chr 4:48,045,098...48,086,446
Ensembl chr 4:48,045,153...48,086,447
G
Ppp1r15a
protein phosphatase 1, regulatory subunit 15A
increases expression
ISO
Sodium Hypochlorite results in increased expression of PPP1R15A mRNA
CTD
PMID:37149095
NCBI chr 7:45,172,341...45,175,692
Ensembl chr 7:45,172,340...45,175,692
G
Slc7a11
solute carrier family 7 (cationic amino acid transporter, y+ system), member 11
increases expression
ISO
Sodium Hypochlorite results in increased expression of SLC7A11 mRNA
CTD
PMID:37149095
NCBI chr 3:50,319,385...50,403,947
Ensembl chr 3:49,846,975...50,398,063
G
Spry2
sprouty RTK signaling antagonist 2
increases expression
ISO
Sodium Hypochlorite results in increased expression of SPRY2 mRNA
CTD
PMID:37149095
NCBI chr14:106,129,381...106,134,559
Ensembl chr14:106,129,381...106,134,253
G
Aldh1l1
aldehyde dehydrogenase 1 family, member L1
multiple interactions
ISO
[Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of ALDH1L1 protein
CTD
PMID:30090431
NCBI chr 6:90,527,751...90,576,153
Ensembl chr 6:90,463,409...90,577,185
G
Aldh5a1
aldhehyde dehydrogenase family 5, subfamily A1
multiple interactions
ISO
[Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of ALDH5A1 protein
CTD
PMID:30090431
NCBI chr13:25,091,562...25,121,740
Ensembl chr13:25,091,562...25,121,644 Ensembl chr13:25,091,562...25,121,644
G
Cga
glycoprotein hormones, alpha subunit
increases expression
ISO
sodium perchlorate results in increased expression of CGA mRNA; sodium perchlorate results in increased expression of CGA protein
CTD
PMID:29139221
NCBI chr 4:34,893,779...34,907,374
Ensembl chr 4:34,893,779...34,907,370
G
Cth
cystathionine gamma lyase
multiple interactions
ISO
[Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of CTH protein
CTD
PMID:30090431
NCBI chr 3:157,599,885...157,630,718
Ensembl chr 3:157,599,885...157,630,714
G
Cyb5a
cytochrome b5 type A (microsomal)
multiple interactions
ISO
[[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in decreased expression of CYB5A protein
CTD
PMID:30090431
NCBI chr18:84,869,463...84,897,996
Ensembl chr18:84,856,829...84,897,996
G
Dio1
deiodinase, iodothyronine, type I
decreases expression
ISO
sodium perchlorate results in decreased expression of DIO1 mRNA
CTD
PMID:29139221
NCBI chr 4:107,148,662...107,164,365
Ensembl chr 4:107,148,662...107,164,366
G
Fos
FBJ osteosarcoma oncogene
multiple interactions
ISO
[sodium perchlorate results in increased abundance of perchlorate] which results in increased expression of FOS protein
CTD
PMID:30991129
NCBI chr12:85,520,664...85,524,048
Ensembl chr12:85,520,664...85,524,047
G
Ftcd
formiminotransferase cyclodeaminase
multiple interactions
ISO
[[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in decreased expression of FTCD protein
CTD
PMID:30090431
NCBI chr10:76,411,482...76,426,172
Ensembl chr10:76,411,482...76,426,172
G
Gamt
guanidinoacetate methyltransferase
multiple interactions
ISO
[[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in increased expression of GAMT protein
CTD
PMID:30090431
NCBI chr10:80,093,985...80,096,846
Ensembl chr10:80,093,985...80,096,846
G
Ifng
interferon gamma
multiple interactions increases expression
ISO
sodium perchlorate results in increased expression of and results in increased secretion of IFNG protein sodium perchlorate results in increased expression of IFNG mRNA
CTD
PMID:29139221
NCBI chr10:118,276,951...118,281,799
Ensembl chr10:118,276,951...118,281,797
G
Il1a
interleukin 1 alpha
increases expression
ISO
sodium perchlorate results in increased expression of IL1A mRNA
CTD
PMID:29139221
NCBI chr 2:129,141,530...129,151,892
Ensembl chr 2:129,141,530...129,151,892
G
Il6
interleukin 6
multiple interactions increases expression
ISO
sodium perchlorate results in increased expression of and results in increased secretion of IL6 protein sodium perchlorate results in increased expression of IL6 mRNA
CTD
PMID:29139221
NCBI chr 5:30,218,112...30,224,973
Ensembl chr 5:30,218,112...30,224,979
G
Krt18
keratin 18
multiple interactions
ISO
[Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of KRT18 protein
CTD
PMID:30090431
NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462
G
Lep
leptin
multiple interactions
ISO
[Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of LEP protein
CTD
PMID:30090431
NCBI chr 6:29,060,220...29,073,875
Ensembl chr 6:29,060,219...29,073,876
G
Lhb
luteinizing hormone beta
multiple interactions
ISO
[Iodine deficiency co-treated with sodium perchlorate] results in decreased secretion of LHB protein
CTD
PMID:30090431
NCBI chr 7:45,070,370...45,071,278
Ensembl chr 7:45,070,244...45,071,321
G
Nkx2-1
NK2 homeobox 1
increases expression
ISO
sodium perchlorate results in increased expression of NKX2-1 protein
CTD
PMID:29139221
NCBI chr12:56,578,741...56,583,570
Ensembl chr12:56,578,743...56,583,693
G
Pax8
paired box 8
increases expression
ISO
sodium perchlorate results in increased expression of PAX8 protein
CTD
PMID:29139221
NCBI chr 2:24,310,563...24,365,611
Ensembl chr 2:24,310,572...24,365,611
G
Pon1
paraoxonase 1
multiple interactions
ISO
[[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in increased expression of PON1 protein; [Iodine deficiency co-treated with sodium perchlorate] results in decreased expression of PON1 protein
CTD
PMID:30090431
NCBI chr 6:5,168,101...5,193,824
Ensembl chr 6:5,168,090...5,193,946
G
Pon2
paraoxonase 2
multiple interactions
ISO
[[Iodine deficiency co-treated with sodium perchlorate] affects the susceptibility to hexabromocyclododecane] which results in increased expression of PON2 protein
CTD
PMID:30090431
NCBI chr 6:5,264,620...5,298,408
Ensembl chr 6:5,264,147...5,298,455
G
Slc5a5
solute carrier family 5 (sodium iodide symporter), member 5
multiple interactions increases expression decreases activity
ISO
sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of perrhenate analog]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide analog]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Pertechnetate Tc 99m]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Technetium] sodium perchlorate results in increased expression of SLC5A5 mRNA; sodium perchlorate results in increased expression of SLC5A5 protein sodium perchlorate results in decreased activity of SLC5A5 protein
CTD
PMID:12488351 PMID:12489024 PMID:12541134 PMID:15221289 PMID:15520214 PMID:26827900 PMID:27979590 PMID:29139221 More...
NCBI chr 8:71,335,529...71,345,429
Ensembl chr 8:71,335,533...71,345,401
G
Tg
thyroglobulin
increases expression
ISO
sodium perchlorate results in increased expression of TG protein
CTD
PMID:29139221
NCBI chr15:66,542,606...66,722,570
Ensembl chr15:66,542,602...66,722,570
G
Tnf
tumor necrosis factor
multiple interactions increases expression
ISO
sodium perchlorate results in increased expression of and results in increased secretion of TNF protein sodium perchlorate results in increased expression of TNF mRNA
CTD
PMID:29139221
NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983
G
Tpo
thyroid peroxidase
decreases activity increases expression
ISO
sodium perchlorate results in decreased activity of TPO protein sodium perchlorate results in increased expression of TPO mRNA; sodium perchlorate results in increased expression of TPO protein
CTD
PMID:23959146 PMID:29139221
NCBI chr12:30,104,658...30,182,983
Ensembl chr12:30,104,658...30,182,623
G
Trh
thyrotropin releasing hormone
increases expression decreases expression
ISO
sodium perchlorate results in increased expression of TRH mRNA sodium perchlorate results in decreased expression of TRH protein
CTD
PMID:29139221
NCBI chr 6:92,219,042...92,221,631
Ensembl chr 6:92,219,042...92,221,631
G
Tshb
thyroid stimulating hormone, beta subunit
multiple interactions increases expression
ISO
sodium perchlorate inhibits the reaction [efavirenz promotes the reaction [TSHB protein affects the abundance of Iodine]]; sodium perchlorate inhibits the reaction [Nevirapine promotes the reaction [TSHB protein affects the abundance of Iodine]] [Iodine deficiency co-treated with sodium perchlorate] results in increased secretion of TSHB protein sodium perchlorate results in increased expression of TSHB mRNA; sodium perchlorate results in increased expression of TSHB protein
CTD
PMID:16030158 PMID:29139221 PMID:30090431
NCBI chr 3:102,684,621...102,718,175
Ensembl chr 3:102,682,781...102,690,034
G
Tshr
thyroid stimulating hormone receptor
increases expression
ISO
sodium perchlorate results in increased expression of TSHR mRNA; sodium perchlorate results in increased expression of TSHR protein
CTD
PMID:29139221
NCBI chr12:91,367,767...91,507,283
Ensembl chr12:91,351,337...91,516,582
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all