diatomic chlorine - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	diatomic chlorine	go back to main search page
Accession:	CHEBI:33435	browse the term
Synonyms:	related_synonym:	Formula=Cl2

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Rat (380) Mouse (381) Human (379) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (14) Green Monkey (0) Naked Mole-rat (0) All
Genes (380)

dichlorine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B member 1B

increases expression
multiple interactions

Chlorine results in increased expression of ABCB1B mRNA
[Ozone co-treated with Chlorine] results in decreased expression of ABCB1B mRNA

NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199

G

ATP binding cassette subfamily C member 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

acyl-CoA dehydrogenase medium chain

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of ACADM mRNA

NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147

G

acetylcholinesterase

multiple interactions

[[Chlorine co-treated with Diazinon] results in increased abundance of diazoxon] which results in decreased activity of ACHE protein

NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651

G

acyl-CoA thioesterase 7

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of ACOT7 mRNA

NCBI chr 5:162,686,562...162,779,309
Ensembl chr 5:162,684,645...162,779,309

G

acyl-CoA synthetase long-chain family member 1

decreases expression
multiple interactions

Chlorine results in decreased expression of ACSL1 mRNA
[Ozone co-treated with Chlorine] affects the expression of ACSL1 mRNA

NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541

G

activin A receptor type 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of ACVR1 mRNA

NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241

G

adenylate cyclase 2

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of ADCY2 mRNA

NCBI chr 1:34,375,639...34,822,252
Ensembl chr 1:34,375,895...34,822,236

G

adenylate cyclase 3

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of ADCY3 mRNA

NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686

G

adenylate cyclase 4

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of ADCY4 mRNA

NCBI chr15:29,266,280...29,282,153
Ensembl chr15:29,266,287...29,282,108

G

adenylate cyclase 5

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of ADCY5 mRNA

NCBI chr11:65,471,612...65,618,877
Ensembl chr11:65,471,612...65,618,974

G

adenylate cyclase 8

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of ADCY8 mRNA

NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911

G

adhesion G protein-coupled receptor L1

decreases expression
multiple interactions

Chlorine results in decreased expression of ADGRL1 mRNA
[Ozone co-treated with Chlorine] results in increased expression of ADGRL1 mRNA

NCBI chr19:24,202,405...24,244,137
Ensembl chr19:24,204,360...24,244,139

G

adenosine A3 receptor

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of ADORA3 mRNA

NCBI chr 2:193,352,759...193,392,946
Ensembl chr 2:193,388,713...193,392,357

G

adrenoceptor alpha 2C

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of ADRA2C mRNA

NCBI chr14:75,470,884...75,472,846
Ensembl chr14:75,471,143...75,472,846

G

adrenoceptor beta 2

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of ADRB2 mRNA

NCBI chr18:55,642,459...55,644,501
Ensembl chr18:55,502,903...55,644,512

G

advanced glycosylation end product-specific receptor

decreases expression
multiple interactions
increases expression

Chlorine results in decreased expression of AGER mRNA
[Ozone co-treated with Chlorine] results in increased expression of AGER mRNA
Chlorine results in increased expression of AGER protein

PMID:18636392 PMID:36690086

NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078

G

aldo-keto reductase family 1 member A1

increases expression
multiple interactions

Chlorine results in increased expression of AKR1A1 mRNA
[Ozone co-treated with Chlorine] results in decreased expression of AKR1A1 mRNA

NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674

G

AKT serine/threonine kinase 1

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of AKT1 mRNA

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

AKT serine/threonine kinase 2

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of AKT2 mRNA

NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817

G

aldolase, fructose-bisphosphate C

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of ALDOC mRNA

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

G

alpha-methylacyl-CoA racemase

increases expression
multiple interactions

Chlorine results in increased expression of AMACR mRNA
[Ozone co-treated with Chlorine] results in increased expression of AMACR mRNA

NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255

G

amphiphysin

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of AMPH mRNA

NCBI chr17:45,739,385...45,982,905
Ensembl chr17:45,739,395...45,983,315

G

annexin A2

multiple interactions
increases expression

[Ozone co-treated with Chlorine] results in decreased expression of ANXA2 mRNA
Chlorine results in increased expression of ANXA2 mRNA

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

G

annexin A3

increases expression
multiple interactions

Chlorine results in increased expression of ANXA3 mRNA
[Ozone co-treated with Chlorine] results in decreased expression of ANXA3 mRNA

NCBI chr14:12,727,708...12,781,717
Ensembl chr14:12,719,795...12,781,617

G

annexin A4

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of ANXA4 mRNA

NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161

G

annexin A5

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of ANXA5 mRNA

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

APC regulator of WNT signaling pathway

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of APC mRNA

NCBI chr18:25,828,558...25,925,511
Ensembl chr18:25,864,222...25,922,696

G

apurinic/apyrimidinic endodeoxyribonuclease 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of APEX1 mRNA

NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785

G

apolipoprotein A1

multiple interactions
affects binding

[MPO protein binds to and results in increased oxidation of APOA1 protein] promotes the reaction [APOA1 protein binds to Chlorine]; [MPO protein promotes the reaction [APOA1 protein binds to Chlorine]] which results in decreased activity of LCAT protein

NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035

G

apolipoprotein D

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of APOD mRNA

NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305

G

aquaporin 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of AQP1 mRNA

NCBI chr 4:84,482,512...84,494,690
Ensembl chr 4:84,482,512...84,494,690

G

aquaporin 3 (Gill blood group)

decreases expression
multiple interactions

Chlorine results in decreased expression of AQP3 mRNA
[Ozone co-treated with Chlorine] affects the expression of AQP3 mRNA

NCBI chr 5:56,239,200...56,244,718
Ensembl chr 5:56,239,201...56,244,720

G

ARF GTPase 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of ARF1 mRNA

NCBI chr10:43,997,983...44,014,461
Ensembl chr10:43,997,986...44,014,434

G

ARF GTPase 3

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of ARF3 mRNA

NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002

G

ARF GTPase 4

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of ARF4 mRNA

NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261

G

ARF GTPase 5

increases expression
multiple interactions

Chlorine results in increased expression of ARF5 mRNA
[Ozone co-treated with Chlorine] results in decreased expression of ARF5 mRNA

NCBI chr 4:57,038,521...57,041,447
Ensembl chr 4:57,038,521...57,041,441

G

ARF GTPase 6

increases expression
multiple interactions

Chlorine results in increased expression of ARF6 mRNA
[Ozone co-treated with Chlorine] affects the expression of ARF6 mRNA

NCBI chr 6:87,853,742...87,854,890
Ensembl chr 6:87,840,142...87,874,114

G

arginase 1

multiple interactions
increases expression

[Ozone co-treated with Chlorine] affects the expression of ARG1 mRNA
Chlorine results in increased expression of ARG1 mRNA; Chlorine results in increased expression of ARG1 protein

PMID:18636392 PMID:24582687 PMID:30189237

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

G

Rho GTPase activating protein 35

decreases expression
multiple interactions

Chlorine results in decreased expression of ARHGAP35 mRNA
[Ozone co-treated with Chlorine] results in decreased expression of ARHGAP35 mRNA

NCBI chr 1:77,202,436...77,319,298
Ensembl chr 1:77,202,436...77,319,298

G

arrestin, beta 2

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of ARRB2 mRNA

NCBI chr10:55,146,887...55,154,854
Ensembl chr10:55,146,818...55,154,850

G

activating transcription factor 2

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of ATF2 mRNA

NCBI chr 3:58,718,323...58,795,280
Ensembl chr 3:58,718,332...58,795,236

G

ATPase Na+/K+ transporting subunit alpha 1

multiple interactions
decreases expression

[Ozone co-treated with Chlorine] results in decreased expression of ATP1A1 mRNA
Chlorine results in decreased expression of ATP1A1 mRNA

PMID:18636392 PMID:24218892

NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837

G

ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

decreases expression
multiple interactions

Chlorine results in decreased expression of ATP2A3 mRNA
[Ozone co-treated with Chlorine] results in decreased expression of ATP2A3 mRNA

NCBI chr10:57,581,742...57,612,758
Ensembl chr10:57,582,128...57,612,748

G

ATPase H+ transporting V0 subunit C

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of ATP6V0C mRNA

NCBI chr10:13,196,204...13,202,580
Ensembl chr10:13,196,204...13,201,500

G

ATPase copper transporting beta

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of ATP7B mRNA

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of BAX mRNA

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

bradykinin receptor B2

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of BDKRB2 mRNA

NCBI chr 6:124,472,317...124,502,497
Ensembl chr 6:124,472,566...124,502,497

G

bone morphogenetic protein 4

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

G

complement C5a receptor 1

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of C5AR1 mRNA

NCBI chr 1:76,948,622...76,959,826

G

calcium voltage-gated channel subunit alpha1 A

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of CACNA1A mRNA

NCBI chr19:23,520,741...23,819,971
Ensembl chr19:23,520,741...23,823,225

G

calcium voltage-gated channel subunit alpha1 B

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of CACNA1B mRNA

NCBI chr 3:7,380,892...7,546,104
Ensembl chr 3:7,380,922...7,546,091

G

calcium voltage-gated channel auxiliary subunit beta 3

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of CACNB3 mRNA

NCBI chr 7:129,784,799...129,797,074
Ensembl chr 7:129,783,674...129,797,074

G

carbonic anhydrase 3

decreases expression
multiple interactions

Chlorine results in decreased expression of CA3 mRNA
[Ozone co-treated with Chlorine] affects the expression of CA3 mRNA

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

G

CART prepropeptide

decreases expression
multiple interactions

Chlorine results in decreased expression of CARTPT mRNA
[Ozone co-treated with Chlorine] affects the expression of CARTPT mRNA

NCBI chr 2:31,255,098...31,257,452
Ensembl chr 2:31,255,098...31,290,713

G

caspase 3

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of CASP3 mRNA

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

calcium-sensing receptor

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of CASR mRNA

NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811

G

calpastatin

increases expression
multiple interactions

Chlorine results in increased expression of CAST mRNA
[Ozone co-treated with Chlorine] affects the expression of CAST mRNA

NCBI chr 2:3,973,112...4,082,658
Ensembl chr 2:3,973,112...4,082,659

G

catalase

increases expression
multiple interactions

Chlorine results in increased expression of CAT protein
Acetylcysteine inhibits the reaction [Chlorine results in increased expression of CAT protein]

PMID:35065218 PMID:36690086

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

cholecystokinin B receptor

decreases expression
multiple interactions

Chlorine results in decreased expression of CCKBR mRNA
[Ozone co-treated with Chlorine] results in increased expression of CCKBR mRNA

NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881

G

C-C motif chemokine ligand 11

increases expression

Chlorine results in increased expression of CCL11 protein

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 12

increases expression

Chlorine results in increased expression of CCL12 mRNA

NCBI chr10:67,070,230...67,071,780
Ensembl chr10:67,070,230...67,071,780

G

C-C motif chemokine ligand 2

increases expression
decreases secretion
multiple interactions

Chlorine results in increased expression of CCL2 mRNA; Chlorine results in increased expression of CCL2 protein
Chlorine results in decreased secretion of CCL2 protein
Acetylcysteine inhibits the reaction [Chlorine results in decreased secretion of CCL2 protein]

PMID:23146759 PMID:24582687 PMID:30189237 PMID:35065218

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

increases expression

Chlorine results in increased expression of CCL20 mRNA

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 3

increases expression

Chlorine results in increased expression of CCL3 protein

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 5

increases expression
multiple interactions

Chlorine results in increased expression of CCL5 protein
[Chlorine binds to Cytidine] which results in decreased expression of CCL5 mRNA

PMID:23146759 PMID:31066272

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 7

increases expression

Chlorine results in increased expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

C-C motif chemokine ligand 9

increases expression

Chlorine results in increased expression of CCL6 mRNA

NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369

G

cyclin C

increases expression
multiple interactions

Chlorine results in increased expression of CCNC mRNA
[Ozone co-treated with Chlorine] results in decreased expression of CCNC mRNA

NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584

G

cyclin D1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

cyclin D3

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of CCND3 mRNA

NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371

G

cyclin G1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of CCNG1 mRNA

NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641

G

Cd4 molecule

decreases expression
multiple interactions

Chlorine results in decreased expression of CD4 mRNA
[Ozone co-treated with Chlorine] affects the expression of CD4 mRNA

NCBI chr 4:157,668,878...157,695,366
Ensembl chr 4:157,668,878...157,695,191

G

CD44 molecule

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of CD44 mRNA

NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620

G

CD9 molecule

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of CD9 mRNA

NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222

G

cell division cycle 25B

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of CDC25B mRNA

NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272

G

cadherin 22

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of CDH22 mRNA

NCBI chr 3:153,845,563...153,970,630
Ensembl chr 3:153,845,787...153,970,588

G

cyclin-dependent kinase 4

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of CDK4 mRNA

NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403

G

cyclin-dependent kinase inhibitor 1A

increases expression
multiple interactions

Chlorine results in increased expression of CDKN1A mRNA
[Ozone co-treated with Chlorine] affects the expression of CDKN1A mRNA

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 2B

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of CDKN2B mRNA

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

cofilin 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of CFL1 mRNA

NCBI chr 1:202,796,012...202,801,337
Ensembl chr 1:202,786,627...202,817,587

G

CF transmembrane conductance regulator

multiple interactions
increases transport

CFTR protein promotes the reaction [Cyclic AMP results in increased transport of Chlorine]; Nitric Oxide inhibits the reaction [CFTR protein promotes the reaction [Cyclic AMP results in increased transport of Chlorine]]
CFTR protein results in increased transport of Chlorine

PMID:12612912 PMID:21765217

NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756

G

cholinergic receptor nicotinic alpha 1 subunit

increases expression
multiple interactions

Chlorine results in increased expression of CHRNA1 mRNA
[Ozone co-treated with Chlorine] results in increased expression of CHRNA1 mRNA

NCBI chr 3:58,454,763...58,469,832
Ensembl chr 3:58,454,744...58,469,840

G

cholinergic receptor nicotinic alpha 4 subunit

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of CHRNA4 mRNA

NCBI chr 3:168,136,246...168,157,839
Ensembl chr 3:168,136,266...168,156,957

G

cholinergic receptor nicotinic beta 1 subunit

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of CHRNB1 mRNA

NCBI chr10:54,501,096...54,516,418
Ensembl chr10:54,501,093...54,516,345

G

creatine kinase, mitochondrial 1

affects expression
multiple interactions

Chlorine affects the expression of CKMT1 mRNA
[Ozone co-treated with Chlorine] results in increased expression of CKMT1 mRNA

NCBI chr 3:108,329,859...108,335,760
Ensembl chr 3:108,330,705...108,335,758

G

C-type lectin domain family 4, member D

increases expression

Chlorine results in increased expression of CLEC4D mRNA

NCBI chr 4:156,589,591...156,599,279
Ensembl chr 4:156,589,792...156,598,848

G

clusterin

multiple interactions
increases expression

[Ozone co-treated with Chlorine] results in decreased expression of CLU mRNA
Acetylcysteine promotes the reaction [Chlorine results in increased expression of CLU protein]

PMID:18636392 PMID:35065218

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

G

chemerin chemokine-like receptor 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of CMKLR1 mRNA

NCBI chr12:42,974,462...43,027,321
Ensembl chr12:42,974,410...43,028,129

G

calponin 3

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of CNN3 mRNA

NCBI chr 2:209,518,948...209,550,107
Ensembl chr 2:209,518,948...209,550,104

G

cannabinoid receptor 1

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of CNR1 mRNA

NCBI chr 5:48,408,543...48,436,099
Ensembl chr 5:48,408,574...48,435,099

G

carboxypeptidase D

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of CPD mRNA

NCBI chr10:61,623,528...61,687,491
Ensembl chr10:61,623,526...61,687,491

G

carnitine palmitoyltransferase 1B

increases expression
multiple interactions

Chlorine results in increased expression of CPT1B mRNA
[Ozone co-treated with Chlorine] results in decreased expression of CPT1B mRNA

NCBI chr 7:120,491,354...120,500,833
Ensembl chr 7:120,491,354...120,500,404

G

corticotropin releasing hormone receptor 2

increases expression
multiple interactions

Chlorine results in increased expression of CRHR2 mRNA
[Ozone co-treated with Chlorine] affects the expression of CRHR2 mRNA

NCBI chr 4:84,222,897...84,265,924
Ensembl chr 4:84,224,002...84,265,904

G

CRK proto-oncogene, adaptor protein

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of CRK mRNA

NCBI chr10:60,530,469...60,556,703
Ensembl chr10:60,530,464...60,553,406

G

colony stimulating factor 1 receptor

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of CSF1R mRNA

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

colony stimulating factor 2

increases expression

Chlorine results in increased expression of CSF2 protein

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

colony stimulating factor 3

increases expression
multiple interactions

Chlorine results in increased expression of CSF3 mRNA
[Ozone co-treated with Chlorine] results in increased expression of CSF3 mRNA
Chlorine results in increased expression of CSF3 protein

PMID:18636392 PMID:23146759

NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603

G

casein kinase 1, gamma 1

multiple interactions
decreases expression

[Ozone co-treated with Chlorine] results in increased expression of CSNK1G1 mRNA
Chlorine results in decreased expression of CSNK1G1 mRNA

NCBI chr 8:66,439,760...66,577,247
Ensembl chr 8:66,439,864...66,572,826

G

cysteine and glycine rich protein 3

increases expression
multiple interactions

Chlorine results in increased expression of CSRP3 mRNA
[Ozone co-treated with Chlorine] results in increased expression of CSRP3 mRNA

NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653

G

cathepsin B

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of CTSB mRNA

NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500

G

cathepsin L

increases expression
multiple interactions

Chlorine results in increased expression of CTSL mRNA
[Ozone co-treated with Chlorine] results in decreased expression of CTSL mRNA

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

G

C-X-C motif chemokine ligand 10

decreases expression
multiple interactions

Chlorine results in decreased expression of CXCL10 mRNA
[Ozone co-treated with Chlorine] results in increased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 3

multiple interactions
increases expression

triptolide inhibits the reaction [Chlorine results in increased expression of CXCL1 protein]
Chlorine results in increased expression of CXCL1 mRNA; Chlorine results in increased expression of CXCL1 protein

PMID:20348278 PMID:20819911 PMID:23146759 PMID:24582687

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine receptor 4

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of CXCR4 mRNA

NCBI chr13:40,077,976...40,081,883
Ensembl chr13:40,077,976...40,081,883

G

cytochrome P450, family 11, subfamily a, polypeptide 1

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of CYP11A1 mRNA

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
increases expression

[Ozone co-treated with Chlorine] affects the expression of CYP19A1 mRNA
Chlorine results in increased expression of CYP19A1 mRNA

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, subfamily 2, polypeptide 11

decreases expression
multiple interactions

Chlorine results in decreased expression of CYP2C mRNA
[Ozone co-treated with Chlorine] affects the expression of CYP2C mRNA

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 4, subfamily a, polypeptide 3

decreases expression
multiple interactions

Chlorine results in decreased expression of CYP4A3 mRNA
[Ozone co-treated with Chlorine] affects the expression of CYP4A3 mRNA

NCBI chr 5:129,097,571...129,115,488
Ensembl chr 5:129,097,926...129,115,463

G

cytochrome P450, family 4, subfamily f, polypeptide 4

decreases expression
multiple interactions

Chlorine results in decreased expression of CYP4F4 mRNA
[Ozone co-treated with Chlorine] affects the expression of CYP4F4 mRNA

NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506

G

dopa decarboxylase

multiple interactions
decreases expression

[Ozone co-treated with Chlorine] affects the expression of DDC mRNA
Chlorine results in decreased expression of DDC mRNA

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

DNA-damage inducible transcript 3

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of DDIT3 mRNA

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

dipeptidylpeptidase 4

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of DPP4 mRNA

NCBI chr 3:46,962,233...47,043,870
Ensembl chr 3:46,962,243...47,043,901

G

dipeptidyl peptidase like 6

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of DPP6 mRNA

NCBI chr 4:7,589,386...8,508,666
Ensembl chr 4:7,591,009...8,508,532

G

dopamine receptor D1

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of DRD1 mRNA

NCBI chr17:10,540,440...10,544,971
Ensembl chr17:10,540,558...10,545,002

G

eukaryotic translation elongation factor 2

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of EEF2 mRNA

NCBI chr 7:8,533,248...8,538,518
Ensembl chr 7:8,533,116...8,559,183

G

early growth response 1

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of EIF2S1 mRNA

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

eukaryotic translation initiation factor 5

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of EIF5 mRNA

NCBI chr 6:130,589,162...130,597,656
Ensembl chr 6:130,589,143...130,597,656

G

coagulation factor II, thrombin

decreases expression
multiple interactions

Chlorine results in decreased expression of F2 mRNA
[Ozone co-treated with Chlorine] affects the expression of F2 mRNA

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

G

fatty acid amide hydrolase

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of FAAH mRNA

NCBI chr 5:129,479,774...129,499,018
Ensembl chr 5:129,479,824...129,498,677

G

fatty acid binding protein 1

decreases expression
multiple interactions

Chlorine results in decreased expression of FABP1 mRNA
[Ozone co-treated with Chlorine] affects the expression of FABP1 mRNA

NCBI chr 4:103,191,015...103,194,791
Ensembl chr 4:103,191,006...103,194,788

G

fatty acid binding protein 2

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of FABP2 mRNA

NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089

G

fatty acid binding protein 4

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fatty acid binding protein 5

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of FABP5 mRNA

NCBI chr 2:91,765,056...91,768,716
Ensembl chr 2:91,765,056...91,853,773

G

Fas cell surface death receptor

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of FAS mRNA

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

fibroblast growth factor 10

decreases expression
multiple interactions

Chlorine results in decreased expression of FGF10 mRNA
[Ozone co-treated with Chlorine] affects the expression of FGF10 mRNA

NCBI chr 2:50,801,171...50,878,218
Ensembl chr 2:50,800,992...50,876,866

G

fibroblast growth factor 2

multiple interactions
decreases expression

[Ozone co-treated with Chlorine] affects the expression of FGF2 mRNA
Chlorine results in decreased expression of FGF2 mRNA

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

FGR proto-oncogene, Src family tyrosine kinase

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of FGR mRNA

NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions

Chlorine results in decreased expression of FOS mRNA
[Ozone co-treated with Chlorine] affects the expression of FOS mRNA

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FOS like 1, AP-1 transcription factor subunit

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

gamma-aminobutyric acid type B receptor subunit 1

decreases expression
multiple interactions

Chlorine results in decreased expression of GABBR1 mRNA
[Ozone co-treated with Chlorine] results in increased expression of GABBR1 mRNA

NCBI chr20:1,464,534...1,494,114
Ensembl chr20:1,464,534...1,493,994

G

galanin receptor 1

decreases expression
multiple interactions

Chlorine results in decreased expression of GALR1 mRNA
[Ozone co-treated with Chlorine] results in increased expression of GALR1 mRNA

NCBI chr18:75,772,021...75,787,577
Ensembl chr18:75,772,023...75,787,577

G

glyceraldehyde-3-phosphate dehydrogenase

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of GAPDH mRNA

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

glucagon receptor

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of GCGR mRNA

NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640

G

glutamate cysteine ligase, modifier subunit

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of GCLM mRNA

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

GDP dissociation inhibitor 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of GDI1 mRNA

NCBI chr X:152,087,611...152,094,274
Ensembl chr X:152,087,444...152,094,272

G

GDP dissociation inhibitor 2

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of GDI2 mRNA

NCBI chr17:66,649,616...66,676,299
Ensembl chr17:66,649,619...66,676,366

G

growth hormone receptor

multiple interactions
decreases expression

[Ozone co-treated with Chlorine] affects the expression of GHR mRNA
Chlorine results in decreased expression of GHR mRNA

NCBI chr 2:52,541,452...52,804,960
Ensembl chr 2:52,542,594...52,804,735

G

gastric inhibitory polypeptide receptor

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of GIPR mRNA

NCBI chr 1:78,804,287...78,814,462
Ensembl chr 1:78,805,593...78,814,462

G

glia maturation factor, beta

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of GMFB mRNA

NCBI chr15:20,069,923...20,081,005
Ensembl chr15:20,067,263...20,080,331

G

G protein subunit alpha i1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of GNAI1 mRNA

NCBI chr 4:16,814,000...16,898,119
Ensembl chr 4:16,814,001...16,896,417

G

G protein subunit alpha i2

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of GNAI2 mRNA

NCBI chr 8:108,288,401...108,309,009
Ensembl chr 8:108,288,401...108,308,979

G

G protein subunit alpha o1

decreases expression
multiple interactions

Chlorine results in decreased expression of GNAO1 mRNA
[Ozone co-treated with Chlorine] affects the expression of GNAO1 mRNA

NCBI chr19:11,034,874...11,192,531
Ensembl chr19:11,035,956...11,192,493

G

GNAS complex locus

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of GNAS mRNA

NCBI chr 3:163,071,003...163,136,350
Ensembl chr 3:163,071,417...163,127,262
Ensembl chr 3:163,071,417...163,127,262

G

G protein subunit alpha z

increases expression
multiple interactions

Chlorine results in increased expression of GNAZ mRNA
[Ozone co-treated with Chlorine] results in increased expression of GNAZ mRNA

NCBI chr20:13,643,473...13,694,240
Ensembl chr20:13,644,640...13,669,907

G

G protein subunit beta 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of GNB1 mRNA

NCBI chr 5:166,075,508...166,142,223
Ensembl chr 5:166,075,629...166,142,124

G

glutathione peroxidase 3

increases expression
multiple interactions

Chlorine results in increased expression of GPX3 mRNA
[Ozone co-treated with Chlorine] affects the expression of GPX3 mRNA

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glutathione peroxidase 5

multiple interactions
increases expression

[Ozone co-treated with Chlorine] affects the expression of GPX5 mRNA
Chlorine results in increased expression of GPX5 mRNA

NCBI chr17:43,436,126...43,443,074
Ensembl chr17:43,416,340...43,443,074

G

G protein-coupled receptor kinase 3

increases expression
multiple interactions

Chlorine results in increased expression of GRK3 mRNA
[Ozone co-treated with Chlorine] results in increased expression of GRK3 mRNA

NCBI chr12:43,624,778...43,735,375
Ensembl chr12:43,624,897...43,731,262

G

glutathione-disulfide reductase

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione synthetase

multiple interactions
increases expression

[Ozone co-treated with Chlorine] results in decreased expression of GSS mRNA
Chlorine results in increased expression of GSS mRNA

NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198

G

glutathione S-transferase alpha 4

multiple interactions
decreases expression

[Ozone co-treated with Chlorine] affects the expression of GSTA4 mRNA
Chlorine results in decreased expression of GSTA4 mRNA

NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182

G

glutathione S-transferase kappa 1

increases expression
multiple interactions

Chlorine results in increased expression of GSTK1 mRNA
[Ozone co-treated with Chlorine] affects the expression of GSTK1 mRNA

NCBI chr 4:71,118,979...71,123,298
Ensembl chr 4:71,118,896...71,123,292

G

glutathione S-transferase mu 2

multiple interactions
decreases expression

[Ozone co-treated with Chlorine] affects the expression of GSTM2 mRNA
Chlorine results in decreased expression of GSTM2 mRNA

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase theta 2

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of GSTT2 mRNA

NCBI chr20:12,819,617...12,823,288
Ensembl chr20:12,819,170...12,823,288

G

guanylate cyclase 2E

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of GUCY2D mRNA

NCBI chr10:53,954,918...53,975,576
Ensembl chr10:53,959,010...53,974,067

G

H2A.X variant histone

increases expression

Chlorine results in increased expression of H2AX protein

NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
Ensembl chr 4:44,671,786...44,673,239

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

decreases expression
multiple interactions

Chlorine results in decreased expression of HMGCS2 mRNA
[Ozone co-treated with Chlorine] affects the expression of HMGCS2 mRNA

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

G

heme oxygenase 1

increases expression

Chlorine results in increased expression of HMOX1 protein

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

G

heme oxygenase 2

increases expression

Chlorine results in increased expression of HMOX2 protein

NCBI chr10:10,797,076...10,831,178
Ensembl chr10:10,797,055...10,831,148

G

hippocalcin-like 4

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of HPCAL4 mRNA

NCBI chr 5:135,454,477...135,466,417
Ensembl chr 5:135,454,540...135,466,416

G

hypoxanthine phosphoribosyltransferase 1

increases expression
multiple interactions

Chlorine results in increased expression of HPRT1 mRNA
[Ozone co-treated with Chlorine] affects the expression of HPRT1 mRNA

NCBI chr X:132,736,175...132,768,149
Ensembl chr X:132,736,096...132,768,154

G

HRas proto-oncogene, GTPase

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of HRAS mRNA

NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615

G

hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1

decreases expression
multiple interactions

Chlorine results in decreased expression of HSD3B1 mRNA
[Ozone co-treated with Chlorine] affects the expression of HSD3B1 mRNA

NCBI chr 2:186,169,864...186,175,984
Ensembl chr 2:186,169,863...186,175,999

G

heat shock protein family A (Hsp70) member 5

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

G

heat shock protein family D (Hsp60) member 1

multiple interactions
increases expression

[Ozone co-treated with Chlorine] results in decreased expression of HSPD1 mRNA
Acetylcysteine inhibits the reaction [Chlorine results in increased expression of HSPD1 protein]

PMID:18636392 PMID:35065218

NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662

G

5-hydroxytryptamine receptor 1F

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of HTR1F mRNA

NCBI chr11:2,642,751...2,644,150
Ensembl chr11:2,642,751...2,644,150

G

5-hydroxytryptamine receptor 6

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of HTR6 mRNA

NCBI chr 5:151,295,269...151,312,853
Ensembl chr 5:151,296,662...151,311,912

G

huntingtin

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of HTT mRNA

NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070

G

inhibitor of DNA binding 2

multiple interactions
decreases expression

[Ozone co-treated with Chlorine] affects the expression of ID2 mRNA
Chlorine results in decreased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

G

interferon gamma

multiple interactions
increases expression

[Ozone co-treated with Chlorine] affects the expression of IFNG mRNA
Chlorine results in increased expression of IFNG protein

PMID:18636392 PMID:23146759

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor binding protein, acid labile subunit

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of IGFALS mRNA

NCBI chr10:13,897,468...13,903,920
Ensembl chr10:13,898,395...13,902,677

G

insulin-like growth factor binding protein 3

decreases expression
multiple interactions

Chlorine results in decreased expression of IGFBP3 mRNA
[Ozone co-treated with Chlorine] affects the expression of IGFBP3 mRNA

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

interleukin 12A

increases expression

Chlorine results in increased expression of IL12A protein

NCBI chr 2:152,965,769...152,973,035
Ensembl chr 2:152,965,769...152,972,734

G

interleukin 12B

increases expression

Chlorine results in increased expression of IL12B protein

NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903

G

interleukin 13

increases expression

Chlorine results in increased expression of IL13 protein

NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737

G

interleukin 18

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of IL18 mRNA

NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

multiple interactions
increases expression
affects expression

[Ozone co-treated with Chlorine] results in increased expression of IL1B mRNA
Chlorine results in increased expression of IL1B protein
Chlorine affects the expression of IL1B mRNA
[Chlorine binds to Cytidine] which results in increased expression of IL1B mRNA; [Chlorine binds to Cytidine] which results in increased expression of IL1B protein

PMID:18636392 PMID:23146759 PMID:24582687 PMID:31066272

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor-like 1

multiple interactions
decreases expression

[Ozone co-treated with Chlorine] results in decreased expression of IL1RL1 mRNA
Chlorine results in decreased expression of IL1RL1 mRNA

NCBI chr 9:42,661,694...42,727,266
Ensembl chr 9:42,697,192...42,727,256

G

interleukin 4 receptor

increases expression

Chlorine results in increased expression of IL4RA mRNA

NCBI chr 1:180,115,061...180,139,981
Ensembl chr 1:180,115,120...180,139,980

G

interleukin 6

increases expression
multiple interactions
decreases secretion

Chlorine results in increased expression of IL6 mRNA; Chlorine results in increased expression of IL6 protein
Acetylcysteine inhibits the reaction [Chlorine results in decreased secretion of IL6 protein]

PMID:23146759 PMID:30189237 PMID:35065218

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

inhibin subunit beta A

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of INHBA mRNA

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

G

insulin receptor-related receptor

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of INSRR mRNA

NCBI chr 2:173,255,335...173,274,800
Ensembl chr 2:173,255,414...173,274,800

G

integrin subunit alpha 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of ITGA1 mRNA

NCBI chr 2:46,646,125...46,812,237
Ensembl chr 2:46,653,193...46,812,238

G

integrin subunit beta 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of ITGB1 mRNA

NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195

G

inositol 1,4,5-trisphosphate receptor, type 3

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of ITPR3 mRNA

NCBI chr20:5,136,968...5,202,339
Ensembl chr20:5,136,441...5,202,337

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression
multiple interactions

Chlorine results in decreased expression of JUN mRNA
[Ozone co-treated with Chlorine] affects the expression of JUN mRNA

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

junction plakoglobin

increases expression
multiple interactions

Chlorine results in increased expression of JUP mRNA
[Ozone co-treated with Chlorine] results in decreased expression of JUP mRNA

NCBI chr10:85,300,438...85,327,378
Ensembl chr10:85,300,440...85,327,057

G

potassium voltage-gated channel subfamily A member 4

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of KCNA4 mRNA

NCBI chr 3:93,756,399...93,778,004
Ensembl chr 3:93,756,446...93,769,162

G

potassium voltage-gated channel subfamily B member 1

affects expression
multiple interactions

Chlorine affects the expression of KCNB1 mRNA
[Ozone co-treated with Chlorine] affects the expression of KCNB1 mRNA

NCBI chr 3:155,820,255...155,913,383
Ensembl chr 3:155,822,963...155,916,194

G

potassium voltage-gated channel subfamily D member 2

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of KCND2 mRNA

NCBI chr 4:49,775,812...50,277,746
Ensembl chr 4:49,776,246...50,277,728

G

potassium inwardly-rectifying channel, subfamily J, member 4

decreases expression
multiple interactions

Chlorine results in decreased expression of KCNJ4 mRNA
[Ozone co-treated with Chlorine] results in decreased expression of KCNJ4 mRNA

NCBI chr 7:111,047,097...111,074,151
Ensembl chr 7:111,047,094...111,074,151

G

potassium inwardly-rectifying channel, subfamily J, member 5

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of KCNJ5 mRNA

NCBI chr 8:30,724,923...30,753,083
Ensembl chr 8:30,724,925...30,753,518

G

potassium inwardly-rectifying channel, subfamily J, member 8

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of KCNJ8 mRNA

NCBI chr 4:175,508,908...175,515,829
Ensembl chr 4:175,508,912...175,515,603

G

kallikrein B1

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of KLKB1 mRNA

NCBI chr16:46,958,634...46,982,054
Ensembl chr16:46,958,707...46,982,053

G

KRAS proto-oncogene, GTPase

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of KRAS mRNA

NCBI chr 4:178,185,418...178,218,484

G

lecithin cholesterol acyltransferase

multiple interactions
decreases expression

[Ozone co-treated with Chlorine] affects the expression of LCAT mRNA
Chlorine results in decreased expression of LCAT mRNA
[MPO protein promotes the reaction [APOA1 protein binds to Chlorine]] which results in decreased activity of LCAT protein

PMID:18636392 PMID:33861588

NCBI chr19:33,834,748...33,838,214
Ensembl chr19:33,834,403...33,838,231

G

LIM domain kinase 1

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of LIMK1 mRNA

NCBI chr12:22,026,697...22,060,605
Ensembl chr12:22,026,672...22,060,606

G

lipase C, hepatic type

decreases expression
multiple interactions

Chlorine results in decreased expression of LIPC mRNA
[Ozone co-treated with Chlorine] results in increased expression of LIPC mRNA

NCBI chr 8:71,509,633...71,635,663
Ensembl chr 8:71,509,635...71,635,464

G

lipase E, hormone sensitive type

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of LIPE mRNA

NCBI chr 1:80,965,612...80,984,313
Ensembl chr 1:80,965,627...80,984,310

G

LYN proto-oncogene, Src family tyrosine kinase

multiple interactions
increases expression

[Ozone co-treated with Chlorine] results in increased expression of LYN mRNA
Chlorine results in increased expression of LYN mRNA

NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868

G

mal, T-cell differentiation protein

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of MAL mRNA

NCBI chr 3:114,864,378...114,888,136
Ensembl chr 3:114,864,378...114,888,136

G

mitogen activated protein kinase kinase 1

multiple interactions
increases expression

[Ozone co-treated with Chlorine] results in decreased expression of MAP2K1 mRNA
Chlorine results in increased expression of MAP2K1 mRNA

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

G

mitogen activated protein kinase 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of MAPK1 mRNA

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of MAPK3 mRNA

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MYC associated factor X

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of MAX mRNA

NCBI chr 6:95,636,859...95,662,204
Ensembl chr 6:95,636,858...95,662,137

G

melanocortin 4 receptor

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of MC4R mRNA

NCBI chr18:60,419,832...60,421,719
Ensembl chr18:60,419,832...60,421,719

G

methyl CpG binding protein 2

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of MECP2 mRNA

NCBI chr X:151,781,177...151,844,687
Ensembl chr X:151,789,930...151,844,689

G

mesenchyme homeobox 2

affects expression
multiple interactions

Chlorine affects the expression of MEOX2 mRNA
[Ozone co-treated with Chlorine] results in decreased expression of MEOX2 mRNA

NCBI chr 6:53,856,760...53,917,467
Ensembl chr 6:53,856,758...53,917,467

G

O-6-methylguanine-DNA methyltransferase

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of MGMT mRNA

NCBI chr 1:191,710,980...191,937,760
Ensembl chr 1:191,710,930...191,937,756

G

microsomal glutathione S-transferase 1

decreases expression
multiple interactions

Chlorine results in decreased expression of MGST1 mRNA
[Ozone co-treated with Chlorine] affects the expression of MGST1 mRNA

NCBI chr 4:171,029,666...171,044,893
Ensembl chr 4:171,029,630...171,044,892

G

matrix metallopeptidase 14

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of MMP14 mRNA

NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 9

decreases secretion
multiple interactions
increases expression

Chlorine results in decreased secretion of MMP9 protein
Acetylcysteine inhibits the reaction [Chlorine results in decreased secretion of MMP9 protein]
Chlorine results in increased expression of MMP9 protein

PMID:35065218 PMID:36690086

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

myeloid cell nuclear differentiation antigen

increases expression

Chlorine results in increased expression of IFI204 mRNA

NCBI chr13:86,017,888...86,035,556
Ensembl chr13:86,017,892...86,034,201

G

myeloperoxidase

multiple interactions

[MPO protein binds to and results in increased oxidation of APOA1 protein] promotes the reaction [APOA1 protein binds to Chlorine]; [MPO protein promotes the reaction [APOA1 protein binds to Chlorine]] which results in decreased activity of LCAT protein; MPO protein promotes the reaction [chlorodimedone binds to Chlorine]; Phenolsulfonphthalein promotes the reaction [MPO protein promotes the reaction [chlorodimedone binds to Chlorine]]

PMID:31288001 PMID:33861588

NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819

G

mannose receptor, C type 1

increases expression

Chlorine results in increased expression of MRC1 mRNA

NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857

G

MAS related GPR family member F

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of MRGPRF mRNA

NCBI chr 1:200,464,100...200,473,588
Ensembl chr 1:200,463,973...200,473,660

G

melatonin receptor 1A

decreases expression
multiple interactions

Chlorine results in decreased expression of MTNR1A mRNA
[Ozone co-treated with Chlorine] results in increased expression of MTNR1A mRNA

NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919

G

major vault protein

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of MVP mRNA

NCBI chr 1:181,594,734...181,622,336
Ensembl chr 1:181,594,734...181,622,380

G

myosin Ib

increases expression
multiple interactions

Chlorine results in increased expression of MYO1B mRNA
[Ozone co-treated with Chlorine] affects the expression of MYO1B mRNA

NCBI chr 9:49,690,043...49,852,373
Ensembl chr 9:49,690,086...49,850,798

G

neural EGFL like 1

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of NELL1 mRNA

NCBI chr 1:99,709,305...100,573,872
Ensembl chr 1:99,709,793...100,573,860

G

neural EGFL like 2

increases expression
multiple interactions

Chlorine results in increased expression of NELL2 mRNA
[Ozone co-treated with Chlorine] results in increased expression of NELL2 mRNA

NCBI chr 7:126,343,089...126,662,903
Ensembl chr 7:126,198,851...126,733,503

G

NFKB inhibitor alpha

multiple interactions
decreases expression

[Ozone co-treated with Chlorine] affects the expression of NFKBIA mRNA
Chlorine results in decreased expression of NFKBIA mRNA

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

neuroglobin

affects abundance

NGB protein affects the abundance of Chlorine

NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830

G

NME/NM23 nucleoside diphosphate kinase 2

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of NME2 mRNA

NCBI chr10:78,898,097...78,903,514
Ensembl chr10:78,897,770...78,903,538
Ensembl chr20:78,897,770...78,903,538

G

nitric oxide synthase 1

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of NOS1 mRNA

NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945

G

nitric oxide synthase 2

increases expression

Chlorine results in increased expression of NOS2 mRNA

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

nitric oxide synthase 3

decreases activity
decreases expression

Chlorine results in decreased activity of NOS3 protein
Chlorine results in decreased expression of NOS3 protein

NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166

G

natriuretic peptide C

multiple interactions
affects expression

[Ozone co-treated with Chlorine] affects the expression of NPPC mRNA
Chlorine affects the expression of NPPC mRNA

NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251

G

neuronal pentraxin receptor

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of NPTXR mRNA

NCBI chr 7:111,336,660...111,354,737
Ensembl chr 7:111,336,664...111,354,802

G

nuclear receptor subfamily 2, group C, member 2

decreases expression
multiple interactions

Chlorine results in decreased expression of NR2C2 mRNA
[Ozone co-treated with Chlorine] affects the expression of NR2C2 mRNA

NCBI chr 4:124,610,216...124,666,813
Ensembl chr 4:124,608,960...124,661,902

G

nuclear receptor subfamily 2, group F, member 1

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of NR2F1 mRNA

NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123

G

nuclear receptor subfamily 3, group C, member 2

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of NR3C2 mRNA

NCBI chr19:30,715,634...31,059,885
Ensembl chr19:30,715,648...31,059,885

G

nuclear receptor subfamily 4, group A, member 1

decreases expression
multiple interactions

Chlorine results in decreased expression of NR4A1 mRNA
[Ozone co-treated with Chlorine] affects the expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

G

nuclear receptor subfamily 4, group A, member 3

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of NR4A3 mRNA

NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733

G

neuropilin 2

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of NRP2 mRNA

NCBI chr 9:64,122,815...64,238,007
Ensembl chr 9:64,123,132...64,237,958

G

neurexin 1

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of NRXN1 mRNA

NCBI chr 6:3,177,788...4,323,848
Ensembl chr 6:3,177,897...4,322,710

G

neurexin 2

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of NRXN2 mRNA

NCBI chr 1:203,726,420...203,842,301
Ensembl chr 1:203,735,753...203,842,297

G

neurotrophic receptor tyrosine kinase 1

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of NTRK1 mRNA

NCBI chr 2:173,236,961...173,253,806
Ensembl chr 2:173,236,963...173,253,770

G

neurotensin receptor 2

decreases expression
multiple interactions

Chlorine results in decreased expression of NTSR2 mRNA
[Ozone co-treated with Chlorine] affects the expression of NTSR2 mRNA

NCBI chr 6:39,424,297...39,431,015
Ensembl chr 6:39,424,324...39,431,014

G

ornithine decarboxylase 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of ODC1 mRNA

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

G

opioid receptor, kappa 1

multiple interactions
decreases expression

[Ozone co-treated with Chlorine] affects the expression of OPRK1 mRNA
Chlorine results in decreased expression of OPRK1 mRNA

NCBI chr 5:13,860,016...13,877,823
Ensembl chr 5:13,860,021...13,877,823

G

p21 (RAC1) activated kinase 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PAK1 mRNA

NCBI chr 1:152,111,172...152,226,390
Ensembl chr 1:152,111,188...152,226,383

G

proliferating cell nuclear antigen

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of PCNA mRNA

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

G

proprotein convertase subtilisin/kexin type 7

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of PCSK7 mRNA

NCBI chr 8:46,202,079...46,224,699
Ensembl chr 8:46,202,131...46,224,705

G

PDGFA associated protein 1

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of PDAP1 mRNA

NCBI chr12:9,470,652...9,480,880
Ensembl chr12:9,470,574...9,535,374

G

phosphodiesterase 4D

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of PDE4D mRNA

NCBI chr 2:40,014,933...41,529,190
Ensembl chr 2:40,019,933...41,525,884

G

platelet derived growth factor receptor beta

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of PDGFRB mRNA

NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843

G

protein disulfide isomerase family A, member 4

multiple interactions
increases expression

[Ozone co-treated with Chlorine] results in decreased expression of PDIA4 mRNA
Chlorine results in increased expression of PDIA4 mRNA

NCBI chr 4:76,803,198...76,822,245
Ensembl chr 4:76,803,198...76,822,107

G

PDZ and LIM domain 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PDLIM1 mRNA

NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of PFKFB4 mRNA

NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634

G

post-GPI attachment to proteins 2

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PGAP2 mRNA

NCBI chr 1:156,591,540...156,618,116
Ensembl chr 1:156,591,615...156,618,114

G

prohibitin 1

increases expression
multiple interactions

Chlorine results in increased expression of PHB1 mRNA
[Ozone co-treated with Chlorine] results in increased expression of PHB1 mRNA

NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042

G

phosphatidylinositol 4-kinase alpha

decreases expression
multiple interactions

Chlorine results in decreased expression of PI4KA mRNA
[Ozone co-treated with Chlorine] affects the expression of PI4KA mRNA

NCBI chr11:83,609,148...83,726,876
Ensembl chr11:83,609,069...83,724,080

G

phospholipase A2, group IIC

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of PLA2G2C mRNA

NCBI chr 5:150,959,365...150,981,388
Ensembl chr 5:150,959,182...150,981,377

G

placenta associated 8

increases expression

Chlorine results in increased expression of PLAC8 mRNA

NCBI chr14:9,052,601...9,074,264
Ensembl chr14:9,063,048...9,074,264

G

plasminogen activator, tissue type

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PLAT mRNA

NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223

G

plectin

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PLEC mRNA

NCBI chr 7:107,887,764...107,949,100
Ensembl chr 7:107,887,764...107,945,467

G

phospholipid phosphatase 1

multiple interactions
decreases expression

[Ozone co-treated with Chlorine] results in decreased expression of PLPP1 mRNA
Chlorine results in decreased expression of PLPP1 mRNA

NCBI chr 2:44,439,002...44,500,430
Ensembl chr 2:44,438,994...44,501,268

G

peripheral myelin protein 22

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PMP22 mRNA

NCBI chr10:47,795,709...47,825,715
Ensembl chr10:47,795,709...47,825,714

G

pancreatic lipase

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of PNLIP mRNA

NCBI chr 1:257,774,012...257,811,656
Ensembl chr 1:257,798,581...257,811,654

G

protein phosphatase 2 catalytic subunit alpha

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PPP2CA mRNA

NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862

G

protein phosphatase 2 catalytic subunit beta

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PPP2CB mRNA

NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576

G

peroxiredoxin 2

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PRDX2 mRNA

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

G

protein arginine methyltransferase 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PRMT1 mRNA

NCBI chr 1:95,458,853...95,468,176
Ensembl chr 1:95,458,850...95,468,345

G

proteasome 20S subunit alpha 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PSMA1 mRNA

NCBI chr 1:168,442,421...168,453,440
Ensembl chr 1:168,440,936...168,453,472

G

proteasome 20S subunit alpha 2

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PSMA2 mRNA

NCBI chr17:50,554,536...50,564,923
Ensembl chr17:50,551,924...50,564,938

G

proteasome 20S subunit alpha 3

multiple interactions
increases expression

[Ozone co-treated with Chlorine] affects the expression of PSMA3L mRNA
Chlorine results in increased expression of PSMA3L mRNA

NCBI chr 6:89,483,741...89,503,775
Ensembl chr 6:89,483,727...89,504,965

G

proteasome 20S subunit alpha 4

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PSMA4 mRNA

NCBI chr 8:55,340,431...55,347,893
Ensembl chr 8:55,340,386...55,347,890

G

proteasome 20S subunit beta 3

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PSMB3 mRNA

NCBI chr10:82,697,425...82,704,521
Ensembl chr10:82,697,425...82,704,521

G

proteasome 20S subunit beta 4

increases expression
multiple interactions

Chlorine results in increased expression of PSMB4 mRNA
[Ozone co-treated with Chlorine] affects the expression of PSMB4 mRNA

NCBI chr 2:182,442,757...182,445,532
Ensembl chr 2:182,442,756...182,445,746

G

proteasome 20S subunit beta 6

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PSMB6 mRNA

NCBI chr10:55,239,256...55,241,586
Ensembl chr10:55,239,241...55,241,586

G

proteasome 20S subunit beta 8

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PSMB8 mRNA

NCBI chr20:4,652,159...4,655,122
Ensembl chr20:4,652,159...4,655,283

G

proteasome 26S subunit, ATPase 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PSMC1 mRNA

NCBI chr 6:119,392,833...119,405,233
Ensembl chr 6:119,392,855...119,410,123

G

proteasome 26S subunit, ATPase 2

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PSMC2 mRNA

NCBI chr 4:13,255,850...13,270,160
Ensembl chr 4:13,255,856...13,270,185

G

proteasome 26S subunit, ATPase 4

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of PSMC4 mRNA

NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494

G

proteasome 26S subunit, ATPase 5

increases expression
multiple interactions

Chlorine results in increased expression of PSMC5 mRNA
[Ozone co-treated with Chlorine] affects the expression of PSMC5 mRNA

NCBI chr10:91,187,763...91,193,697
Ensembl chr10:91,187,743...91,213,135

G

platelet-activating factor receptor

increases expression
multiple interactions

Chlorine results in increased expression of PTAFR mRNA
[Ozone co-treated with Chlorine] affects the expression of PTAFR mRNA

NCBI chr 5:144,765,770...144,795,057
Ensembl chr 5:144,765,976...144,795,251

G

prostaglandin-endoperoxide synthase 2

increases expression

Chlorine results in increased expression of PTGS2 mRNA

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

pleiotrophin

multiple interactions
increases expression

[Ozone co-treated with Chlorine] results in increased expression of PTN mRNA
Chlorine results in increased expression of PTN mRNA

NCBI chr 4:65,293,731...65,375,572
Ensembl chr 4:65,293,734...65,375,456

G

protein tyrosine phosphatase, non-receptor type 11

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of PTPN11 mRNA

NCBI chr12:35,365,436...35,424,925
Ensembl chr12:35,383,144...35,424,925

G

protein tyrosine phosphatase, non-receptor type 7

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of PTPN7 mRNA

NCBI chr13:46,570,904...46,584,048
Ensembl chr13:46,571,712...46,583,308

G

protein tyrosine phosphatase, receptor type, R

decreases expression
multiple interactions

Chlorine results in decreased expression of PTPRR mRNA
[Ozone co-treated with Chlorine] affects the expression of PTPRR mRNA

NCBI chr 7:51,662,595...51,929,605
Ensembl chr 7:51,662,595...51,929,603

G

RAB15, member RAS oncogene family

increases expression
multiple interactions

Chlorine results in increased expression of RAB15 mRNA
[Ozone co-treated with Chlorine] affects the expression of RAB15 mRNA

NCBI chr 6:95,499,584...95,524,073
Ensembl chr 6:95,499,587...95,523,942

G

RAB1A, member RAS oncogene family

increases expression
multiple interactions

Chlorine results in increased expression of RAB1A mRNA
[Ozone co-treated with Chlorine] affects the expression of RAB1A mRNA

NCBI chr14:94,422,219...94,448,799
Ensembl chr14:94,415,275...94,448,248

G

RAB2A, member RAS oncogene family

increases expression
multiple interactions

Chlorine results in increased expression of RAB2 mRNA
[Ozone co-treated with Chlorine] results in decreased expression of RAB2 mRNA

NCBI chr 5:21,676,017...21,740,035
Ensembl chr 5:21,676,129...21,739,899

G

RAB3B, member RAS oncogene family

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of RAB3B mRNA

NCBI chr 5:123,629,562...123,697,410
Ensembl chr 5:123,644,423...123,697,401

G

RAB3D, member RAS oncogene family

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of RAB3D mRNA

NCBI chr 8:20,438,622...20,449,269
Ensembl chr 8:20,439,294...20,449,185

G

RAB4A, member RAS oncogene family

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of RAB4A mRNA

NCBI chr19:51,795,613...51,822,706
Ensembl chr19:51,795,613...51,822,703

G

RAS like proto-oncogene A

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of RALA mRNA

NCBI chr17:47,092,163...47,145,192
Ensembl chr17:47,092,207...47,144,063

G

ral guanine nucleotide dissociation stimulator

multiple interactions
increases expression

[Ozone co-treated with Chlorine] results in increased expression of RALGDS mRNA
Chlorine results in increased expression of RALGDS mRNA

NCBI chr 3:11,839,686...11,880,059
Ensembl chr 3:11,839,416...11,880,059

G

RAS p21 protein activator 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of RASA1 mRNA

NCBI chr 2:15,857,704...15,940,757
Ensembl chr 2:15,857,980...15,940,854

G

regulating synaptic membrane exocytosis 1

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of RIMS1 mRNA

NCBI chr 9:24,696,959...25,196,404
Ensembl chr 9:24,698,854...25,196,631

G

Ras and Rab interactor 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of RIN1 mRNA

NCBI chr 1:202,355,729...202,362,731
Ensembl chr 1:202,355,890...202,362,729

G

arginyl aminopeptidase

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of RNPEP mRNA

NCBI chr13:46,699,458...46,717,829
Ensembl chr13:46,699,463...46,717,998

G

ribosomal protein L10

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of RPL10 mRNA

NCBI chr X:152,054,562...152,056,769
Ensembl chr X:152,054,452...152,056,761

G

ribosomal protein L11

increases expression
multiple interactions

Chlorine results in increased expression of RPL11 mRNA
[Ozone co-treated with Chlorine] affects the expression of RPL11 mRNA

NCBI chr 5:148,274,060...148,277,708
Ensembl chr 5:148,274,069...148,277,599

G

ribosomal protein L12

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of RPL12 mRNA

NCBI chr 3:16,264,269...16,266,645
Ensembl chr 3:16,264,251...16,266,642

G

ribosomal protein L13

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of RPL13 mRNA

NCBI chr19:51,153,990...51,156,541
Ensembl chr19:51,153,924...51,163,014
Ensembl chr 3:51,153,924...51,163,014

G

ribosomal protein L21

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of RPL21 mRNA

NCBI chr12:8,268,641...8,272,278
Ensembl chr12:8,267,196...8,272,281
Ensembl chr 3:8,267,196...8,272,281
Ensembl chr13:8,267,196...8,272,281

G

ribosomal protein L36A like 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of RPL36AL mRNA

NCBI chr 6:87,654,808...87,656,202
Ensembl chr X:97,766,179...97,768,892
Ensembl chr10:97,766,179...97,768,892
Ensembl chr20:97,766,179...97,768,892

G

ribosomal protein S11

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of RPS11 mRNA

NCBI chr 1:95,605,690...95,607,798
Ensembl chr 1:95,605,692...95,607,874

G

ribosomal protein S12

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of RPS12 mRNA

NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014

G

ribosomal protein S17

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of RPS17 mRNA

NCBI chr 1:135,295,920...135,298,506
Ensembl chr 1:135,295,919...135,298,535
Ensembl chr 8:135,295,919...135,298,535

G

ribosomal protein S19

multiple interactions
increases expression

[Ozone co-treated with Chlorine] affects the expression of RPS19 mRNA
Chlorine results in increased expression of RPS19 mRNA

NCBI chr 1:80,480,718...80,486,511
Ensembl chr 1:80,480,951...80,486,508
Ensembl chr 7:80,480,951...80,486,508

G

ribosomal protein S29

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of RPS29 mRNA

NCBI chr 6:87,635,229...87,636,627
Ensembl chr 6:87,635,230...87,636,636
Ensembl chr13:87,635,230...87,636,636

G

ribosomal protein S4, X-linked

increases expression
multiple interactions

Chlorine results in increased expression of RPS4X mRNA
[Ozone co-treated with Chlorine] results in decreased expression of RPS4X mRNA

NCBI chr X:67,298,522...67,302,965
Ensembl chr X:67,298,525...67,303,019
Ensembl chr 4:67,298,525...67,303,019

G

sphingosine-1-phosphate receptor 2

decreases expression
multiple interactions

Chlorine results in decreased expression of S1PR2 mRNA
[Ozone co-treated with Chlorine] results in decreased expression of S1PR2 mRNA

NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574

G

sodium voltage-gated channel beta subunit 2

decreases expression
multiple interactions

Chlorine results in decreased expression of SCN2B mRNA
[Ozone co-treated with Chlorine] affects the expression of SCN2B mRNA

NCBI chr 8:45,425,629...45,437,765
Ensembl chr 8:45,425,629...45,437,765

G

sodium voltage-gated channel alpha subunit 4

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of SCN4A mRNA

NCBI chr10:91,246,936...91,296,670
Ensembl chr10:91,246,936...91,296,545

G

sterol carrier protein 2

decreases expression
multiple interactions

Chlorine results in decreased expression of SCP2 mRNA
[Ozone co-treated with Chlorine] affects the expression of SCP2 mRNA

NCBI chr 5:122,806,949...122,881,259
Ensembl chr 5:122,776,549...122,881,287

G

secretin receptor

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of SCTR mRNA

NCBI chr13:31,127,781...31,190,162
Ensembl chr13:31,127,858...31,180,189

G

selectin P

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of SELP mRNA

NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845

G

serpin family B member 2

increases expression

Chlorine results in increased expression of SERPINB2 mRNA

NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408

G

serpin family B member 5

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of SERPINB5 mRNA

NCBI chr13:22,985,557...23,005,756
Ensembl chr13:22,985,557...23,005,756

G

serpin family E member 1

increases expression
multiple interactions

Chlorine results in increased expression of SERPINE1 mRNA
[Ozone co-treated with Chlorine] affects the expression of SERPINE1 mRNA

NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657

G

surfactant protein B

affects expression

Chlorine affects the expression of SFTPB protein

NCBI chr 4:104,359,303...104,368,439
Ensembl chr 4:104,359,396...104,368,436

G

surfactant protein D

affects expression
increases expression

Chlorine affects the expression of SFTPD protein
Chlorine results in increased expression of SFTPD protein

PMID:24582687 PMID:36690086

NCBI chr16:17,046,491...17,058,968
Ensembl chr16:17,046,483...17,059,927

G

serum/glucocorticoid regulated kinase 1

decreases expression
multiple interactions

Chlorine results in decreased expression of SGK1 mRNA
[Ozone co-treated with Chlorine] results in increased expression of SGK1 mRNA

NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283

G

sialic acid binding Ig like lectin 1

increases expression

Chlorine results in increased expression of SIGLEC1 mRNA

NCBI chr 3:118,287,988...118,307,125
Ensembl chr 3:118,287,988...118,306,850

G

signal-regulatory protein alpha

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of SIRPA mRNA

NCBI chr 3:116,819,730...116,858,099
Ensembl chr 3:116,819,726...116,858,098

G

solute carrier family 10 member 1

decreases expression
multiple interactions

Chlorine results in decreased expression of SLC10A1 mRNA
[Ozone co-treated with Chlorine] affects the expression of SLC10A1 mRNA

NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670

G

solute carrier family 14 member 2

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of SLC14A2 mRNA

NCBI chr18:71,612,460...72,039,462
Ensembl chr18:71,612,460...71,792,968

G

solute carrier family 15 member 1

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of SLC15A1 mRNA

NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545

G

solute carrier family 15 member 4

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of SLC15A4 mRNA

NCBI chr12:29,048,634...29,082,480
Ensembl chr12:29,063,015...29,082,480

G

solute carrier family 16 member 1

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of SLC16A1 mRNA

NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611

G

solute carrier family 17 member 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of SLC17A1 mRNA

NCBI chr17:41,219,461...41,255,199
Ensembl chr17:41,222,049...41,253,304

G

solute carrier family 18 member A1

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of SLC18A1 mRNA

NCBI chr16:20,653,268...20,687,051
Ensembl chr16:20,653,508...20,687,051

G

solute carrier family 1 member 6

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of SLC1A6 mRNA

NCBI chr 7:10,841,836...10,870,424
Ensembl chr 7:10,841,837...10,870,449

G

solute carrier family 22 member 1

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of SLC22A1 mRNA

NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678

G

solute carrier family 22 member 12

multiple interactions

[Chlorine co-treated with perfluoro-n-heptanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluoro-n-nonanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluorodecanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; [Chlorine co-treated with perfluorooctanoic acid] inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]; Chlorine inhibits the reaction [SLC22A12 protein results in increased import of perfluorooctanoic acid]; Chlorine inhibits the reaction [SLC22A12 protein results in increased import of Uric Acid]

NCBI chr 1:203,845,039...203,852,496
Ensembl chr 1:203,845,048...203,853,555

G

solute carrier family 22 member 2

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of SLC22A2 mRNA

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

G

solute carrier family 4 member 2

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of SLC4A2 mRNA

NCBI chr 4:10,736,419...10,754,407
Ensembl chr 4:10,736,425...10,752,965

G

solute carrier family 6 member 12

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of SLC6A12 mRNA

NCBI chr 4:154,585,386...154,603,750
Ensembl chr 4:154,585,500...154,603,750

G

solute carrier family 6 member 15

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of SLC6A15 mRNA

NCBI chr 7:38,553,055...38,607,239
Ensembl chr 7:38,553,196...38,607,239

G

solute carrier family 6 member 9

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of SLC6A9 mRNA

NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728

G

solute carrier family 7 member 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of SLC7A1 mRNA

NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849

G

solute carrier family 9 member A2

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of SLC9A2 mRNA

NCBI chr 9:42,932,001...43,014,447
Ensembl chr 9:42,931,346...43,014,444

G

solute carrier organic anion transporter family, member 1a4

multiple interactions
decreases expression

[Ozone co-treated with Chlorine] results in increased expression of SLCO1A4 mRNA
Chlorine results in decreased expression of SLCO1A4 mRNA

NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573

G

secretory leukocyte peptidase inhibitor

increases expression

Chlorine results in increased expression of SLPI mRNA

NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453

G

SMAD family member 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of SMAD1 mRNA

NCBI chr19:28,513,130...28,573,665
Ensembl chr19:28,513,131...28,573,651

G

survival of motor neuron 1, telomeric

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of SMN1 mRNA

NCBI chr 2:31,490,018...31,501,065
Ensembl chr 2:31,490,015...31,501,060

G

synaptosome associated protein 25

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of SNAP25 mRNA

NCBI chr 3:124,041,898...124,123,761
Ensembl chr 3:124,041,898...124,123,760

G

spondin 1

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of SPON1 mRNA

NCBI chr 1:167,929,049...168,228,239
Ensembl chr 1:167,928,972...168,228,226

G

structure specific recognition protein 1

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of SSRP1 mRNA

NCBI chr 3:70,124,371...70,134,481
Ensembl chr 3:70,118,655...70,134,482

G

somatostatin

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of SST mRNA

NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173

G

somatostatin receptor 3

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of SSTR3 mRNA

NCBI chr 7:110,092,563...110,109,043
Ensembl chr 7:110,092,575...110,099,769

G

syntaxin 1B

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of STX1B mRNA

NCBI chr 1:182,415,544...182,434,385
Ensembl chr 1:182,415,546...182,441,280

G

syntaxin 5

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of STX5A mRNA

NCBI chr 1:205,637,401...205,653,563
Ensembl chr 1:205,637,413...205,653,563

G

syntaxin 6

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of STX6 mRNA

NCBI chr13:67,332,329...67,378,580
Ensembl chr13:67,332,314...67,378,576

G

sulfotransferase family 1B member 1

multiple interactions
decreases expression

[Ozone co-treated with Chlorine] affects the expression of SULT1B1 mRNA
Chlorine results in decreased expression of SULT1B1 mRNA

NCBI chr14:20,492,763...20,505,491
Ensembl chr14:20,492,708...20,505,483

G

synaptic vesicle glycoprotein 2b

multiple interactions
increases expression

[Ozone co-treated with Chlorine] results in increased expression of SV2B mRNA
Chlorine results in increased expression of SV2B mRNA

NCBI chr 1:128,978,471...129,152,479
Ensembl chr 1:128,978,473...129,152,479

G

synaptophysin

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of SYP mRNA

NCBI chr X:14,849,444...14,864,553
Ensembl chr X:14,849,444...14,864,745

G

synaptotagmin 11

decreases expression
multiple interactions

Chlorine results in decreased expression of SYT11 mRNA
[Ozone co-treated with Chlorine] results in decreased expression of SYT11 mRNA

NCBI chr 2:174,206,032...174,232,540
Ensembl chr 2:174,206,191...174,231,964

G

synaptotagmin 2

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of SYT2 mRNA

NCBI chr13:46,088,046...46,197,976
Ensembl chr13:46,185,282...46,193,859

G

synaptotagmin 4

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of SYT4 mRNA

NCBI chr18:23,036,973...23,046,380
Ensembl chr18:23,038,378...23,046,332

G

tachykinin receptor 2

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of TACR2 mRNA

NCBI chr20:30,208,907...30,223,446
Ensembl chr20:30,208,907...30,223,446

G

transporter 2, ATP binding cassette subfamily B member

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of TAP2 mRNA

NCBI chr20:4,636,347...4,650,387
Ensembl chr20:4,636,357...4,650,407

G

thromboxane A2 receptor

multiple interactions

[Ozone co-treated with Chlorine] results in increased expression of TBXA2R mRNA

NCBI chr 7:8,383,347...8,390,753
Ensembl chr 7:8,383,378...8,388,176

G

transferrin receptor

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of TFRC mRNA

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

transforming growth factor, beta receptor 1

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of TGFBR1 mRNA

NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777

G

TIMP metallopeptidase inhibitor 1

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of TIMP1 mRNA

NCBI chr X:1,212,969...1,217,714
Ensembl chr X:1,212,972...1,217,664

G

thymidine kinase 1

decreases expression
multiple interactions

Chlorine results in decreased expression of TK1 mRNA
[Ozone co-treated with Chlorine] affects the expression of TK1 mRNA

NCBI chr10:103,034,755...103,046,125
Ensembl chr10:103,031,521...103,046,920

G

tumor necrosis factor

increases expression

Chlorine results in increased expression of TNF protein

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

increases expression

Chlorine results in increased expression of TNFRSF1A protein

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

DNA topoisomerase II alpha

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of TOP2A mRNA

NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874

G

tumor protein p53

multiple interactions
increases expression

Acetylcysteine promotes the reaction [Chlorine results in increased expression of TP53 protein modified form]

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

tripeptidyl peptidase 2

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of TPP2 mRNA

NCBI chr 9:46,046,712...46,128,157
Ensembl chr 9:46,046,632...46,128,157

G

tubulin, alpha 1A

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of TUBA1A mRNA

NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186

G

thymidylate synthetase

decreases expression
multiple interactions

Chlorine results in decreased expression of TYMS mRNA
[Ozone co-treated with Chlorine] affects the expression of TYMS mRNA

NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536

G

unc-5 netrin receptor B

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of UNC5B mRNA

NCBI chr20:28,697,726...28,764,474
Ensembl chr20:28,697,726...28,764,537

G

valosin-containing protein

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of VCP mRNA

NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571

G

von Hippel-Lindau tumor suppressor

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of VHL mRNA

NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377

G

vasoactive intestinal peptide receptor 1

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of VIPR1 mRNA

NCBI chr 8:121,303,739...121,339,587
Ensembl chr 8:121,310,248...121,339,585

G

vasoactive intestinal peptide receptor 2

multiple interactions

[Ozone co-treated with Chlorine] affects the expression of VIPR2 mRNA

NCBI chr 6:136,996,664...137,070,599
Ensembl chr 6:137,001,511...137,070,597

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of YWHAE mRNA

NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma

multiple interactions
increases expression

[Ozone co-treated with Chlorine] affects the expression of YWHAG mRNA
Chlorine results in increased expression of YWHAG mRNA

NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta

multiple interactions

[Ozone co-treated with Chlorine] results in decreased expression of YWHAH mRNA

NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta

increases expression
multiple interactions

Chlorine results in increased expression of YWHAZ mRNA
[Ozone co-treated with Chlorine] results in decreased expression of YWHAZ mRNA

NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19867
chemical entity	19865
molecular entity	19865
elemental molecular entity	17177
elemental halogen	9695
elemental chlorine	8778
diatomic chlorine	380
dichloride(.1-)	0
dichlorine	380
dichlorine(.1+)	0
Path 2
Term	Annotations
CHEBI ontology	19867
subatomic particle	19865
composite particle	19865
hadron	19865
baryon	19865
nucleon	19865
atomic nucleus	19865
atom	19865
main group element atom	19803
main group molecular entity	19803
p-block molecular entity	19803
halogen molecular entity	18677
chlorine molecular entity	18460
elemental chlorine	8778
diatomic chlorine	380
dichloride(.1-)	0
dichlorine	380
dichlorine(.1+)	0

paths to the root