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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:elemental halogen
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Accession:CHEBI:33434 term browser browse the term
Synonyms:related_synonym: elemental halogens



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ammonium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RUNX2 RUNX family transcription factor 2 multiple interactions EXP Ammonium Chloride inhibits the reaction [SOX5 protein inhibits the reaction [Warfarin results in increased expression of RUNX2 mRNA]] CTD PMID:34520801 NCBI chr 7:40,106,581...40,353,304
Ensembl chr 7:40,106,532...40,460,687
JBrowse link
G SOX5 SRY-box transcription factor 5 multiple interactions EXP Ammonium Chloride inhibits the reaction [SOX5 protein inhibits the reaction [Warfarin results in increased expression of RUNX2 mRNA]] CTD PMID:34520801 NCBI chr 5:49,159,950...50,166,463
Ensembl chr 5:49,504,551...50,161,558
JBrowse link
calcium dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions EXP Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510
JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP [Sodium Bicarbonate co-treated with Calcium Chloride] results in increased activity of GAPDH protein CTD PMID:26582256 NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991
JBrowse link
cobalt dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AOC1 amine oxidase copper containing 1 affects binding EXP cobaltous chloride binds to AOC1 protein CTD PMID:16842785 NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974
JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP cobaltous chloride results in increased expression of HSP90B1 mRNA CTD PMID:17464326 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP cobaltous chloride results in increased expression of HSPA5 mRNA CTD PMID:17464326 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894
JBrowse link
colforsin daropate hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 decreases activity EXP Colforsin results in decreased activity of ADCYAP1 protein alternative form CTD PMID:16847435 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294
JBrowse link
G ATP7B ATPase copper transporting beta multiple interactions EXP Colforsin inhibits the reaction [Copper binds to ATP7B protein] CTD PMID:21084060 NCBI chr11:15,892,549...15,942,070
Ensembl chr11:15,876,612...15,942,064
JBrowse link
G CFTR CF transmembrane conductance regulator increases activity EXP Colforsin results in increased activity of CFTR protein CTD PMID:15246976 NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950
JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation
EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein] CTD PMID:17680988 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728
JBrowse link
copper(II) chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AOC1 amine oxidase copper containing 1 increases activity EXP cupric chloride results in increased activity of AOC1 protein CTD PMID:16842785 NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974
JBrowse link
dibromine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARRB2 arrestin beta 2 increases expression EXP Bromine results in increased expression of ARRB2 mRNA CTD PMID:21391292 NCBI chr12:52,161,776...52,170,362
Ensembl chr12:52,161,778...52,170,342
JBrowse link
G BMP5 bone morphogenetic protein 5 decreases expression EXP Bromine results in decreased expression of BMP5 mRNA CTD PMID:18790026 NCBI chr 7:25,344,924...25,468,430
Ensembl chr 7:25,344,822...25,470,470
JBrowse link
G CCNB1 cyclin B1 increases expression EXP Bromine results in increased expression of CCNB1 mRNA CTD PMID:21391292 NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,377
JBrowse link
G CCNB2 cyclin B2 increases expression EXP Bromine results in increased expression of CCNB2 mRNA CTD PMID:21391292 NCBI chr 1:112,907,047...112,942,218
Ensembl chr 1:112,907,047...112,942,235
JBrowse link
G CCR1 C-C motif chemokine receptor 1 increases expression EXP Bromine results in increased expression of CCR1 mRNA CTD PMID:18790026 PMID:21391292 NCBI chr13:29,227,218...29,233,862
Ensembl chr13:29,227,222...29,233,960
JBrowse link
G CCR5 C-C motif chemokine receptor 5 increases expression EXP Bromine results in increased expression of CCR5 mRNA CTD PMID:18790026 NCBI chr13:29,382,383...29,387,902
Ensembl chr13:29,383,303...29,387,895
JBrowse link
G COL1A1 collagen type I alpha 1 chain affects expression EXP Bromine affects the expression of COL1A1 mRNA CTD PMID:18790026 NCBI chr12:26,379,087...26,397,180
Ensembl chr12:26,379,090...26,397,004
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP Bromine results in increased expression of CXCL8 mRNA CTD PMID:21391292 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G CYP7A1 cytochrome P450 family 7 subfamily A member 1 decreases expression EXP Bromine results in decreased expression of CYP7A1 mRNA CTD PMID:21391292 NCBI chr 4:74,343,101...74,372,628
Ensembl chr 4:74,343,123...74,372,621
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Bromine results in increased expression of FOS mRNA CTD PMID:21391292 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G GLI2 GLI family zinc finger 2 decreases expression EXP Bromine results in decreased expression of GLI2 mRNA CTD PMID:21391292 NCBI chr15:30,312,528...30,580,272
Ensembl chr15:30,313,817...30,579,306
JBrowse link
G GPX1 glutathione peroxidase 1 increases expression EXP Bromine results in increased expression of GPX1 mRNA CTD PMID:21391292 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433
JBrowse link
G GRM5 glutamate metabotropic receptor 5 increases expression EXP Bromine results in increased expression of GRM5 mRNA CTD PMID:18790026 NCBI chr 9:21,914,422...22,438,200
Ensembl chr 9:21,917,735...22,436,063
JBrowse link
G HMOX1 heme oxygenase 1 increases expression EXP Bromine results in increased expression of HMOX1 mRNA CTD PMID:21391292
G IGF1 insulin like growth factor 1 increases expression EXP Bromine results in increased expression of IGF1 mRNA CTD PMID:21391292 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033
JBrowse link
G IL1RN interleukin 1 receptor antagonist increases expression EXP Bromine results in increased expression of IL1RN mRNA CTD PMID:21391292
G IL2RG interleukin 2 receptor subunit gamma increases expression EXP Bromine results in increased expression of IL2RG mRNA CTD PMID:21391292 NCBI chr  X:57,143,568...57,151,242
Ensembl chr  X:57,143,570...57,147,256
JBrowse link
G IRF8 interferon regulatory factor 8 increases expression EXP Bromine results in increased expression of IRF8 mRNA CTD PMID:21391292 NCBI chr 6:3,041,617...3,060,685
Ensembl chr 6:3,041,645...3,097,406
JBrowse link
G ITGB2 integrin subunit beta 2 increases expression EXP Bromine results in increased expression of ITGB2 mRNA CTD PMID:21391292 NCBI chr13:207,514,281...207,544,108
Ensembl chr13:207,512,950...207,544,107
JBrowse link
G ITIH4 inter-alpha-trypsin inhibitor heavy chain 4 increases expression EXP Bromine results in increased expression of ITIH4 mRNA CTD PMID:21391292 NCBI chr13:34,928,455...34,948,250
Ensembl chr13:34,928,439...34,948,229
JBrowse link
G KAT2B lysine acetyltransferase 2B decreases expression EXP Bromine results in decreased expression of KAT2B mRNA CTD PMID:21391292 NCBI chr13:6,985,151...7,099,771
Ensembl chr13:6,985,235...7,100,345
JBrowse link
G KLK1 kallikrein 1 decreases expression EXP Bromine results in decreased expression of KLK1 mRNA CTD PMID:21391292 NCBI chr 6:55,570,632...55,576,398
Ensembl chr 6:55,570,635...55,576,636
JBrowse link
G LCP2 lymphocyte cytosolic protein 2 increases expression EXP Bromine results in increased expression of LCP2 mRNA CTD PMID:21391292 NCBI chr16:53,696,974...53,741,736
Ensembl chr16:53,697,026...53,741,725
JBrowse link
G LOC110258578 interleukin-1 beta-like increases expression EXP Bromine results in increased expression of IL1B mRNA CTD PMID:21391292
G MYO6 myosin VI decreases expression EXP Bromine results in decreased expression of MYO6 mRNA CTD PMID:21391292 NCBI chr 1:89,992,860...90,137,767
Ensembl chr 1:89,992,866...90,137,734
JBrowse link
G NFAT5 nuclear factor of activated T cells 5 increases expression EXP Bromine results in increased expression of NFAT5 mRNA CTD PMID:21391292 NCBI chr 6:17,313,511...17,434,951
Ensembl chr 6:17,313,413...17,434,940
JBrowse link
G PGF placental growth factor increases expression EXP Bromine results in increased expression of PGF mRNA CTD PMID:21391292 NCBI chr 7:98,149,510...98,162,784
Ensembl chr 7:98,148,994...98,162,741
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma increases expression EXP Bromine results in increased expression of PIK3CG mRNA CTD PMID:21391292 NCBI chr 9:106,698,200...106,748,217
Ensembl chr 9:106,698,207...106,745,099
JBrowse link
G SERPINE1 serpin family E member 1 increases expression EXP Bromine results in increased expression of SERPINE1 mRNA CTD PMID:21391292 NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,547
JBrowse link
G SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 decreases expression EXP Bromine results in decreased expression of SULT1E1 mRNA CTD PMID:18790026 NCBI chr 8:66,811,536...66,838,181
Ensembl chr 8:66,811,550...66,834,473
JBrowse link
G TAT tyrosine aminotransferase increases expression EXP Bromine results in increased expression of TAT mRNA CTD PMID:21391292 NCBI chr 6:14,571,311...14,583,203
Ensembl chr 6:14,570,589...14,583,177
JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 increases expression EXP Bromine results in increased expression of TIMP1 mRNA CTD PMID:21391292 NCBI chr  X:42,103,251...42,106,289
Ensembl chr  X:42,102,172...42,106,296
JBrowse link
G TLR2 toll like receptor 2 increases expression EXP Bromine results in increased expression of TLR2 mRNA CTD PMID:21391292 NCBI chr 8:75,416,257...75,428,370
Ensembl chr 8:75,411,993...75,428,330
JBrowse link
G TYRO3 TYRO3 protein tyrosine kinase decreases expression EXP Bromine results in decreased expression of TYRO3 mRNA CTD PMID:18790026 NCBI chr 1:129,811,540...129,829,395
Ensembl chr 1:129,811,544...129,829,014
JBrowse link
G TYROBP transmembrane immune signaling adaptor TYROBP increases expression EXP Bromine results in increased expression of TYROBP mRNA CTD PMID:18790026 PMID:21391292 NCBI chr 6:45,309,199...45,312,562
Ensembl chr 6:45,309,201...45,312,539
JBrowse link
G VAV3 vav guanine nucleotide exchange factor 3 decreases expression EXP Bromine results in decreased expression of VAV3 mRNA CTD PMID:18790026 NCBI chr 4:111,825,071...112,202,833
Ensembl chr 4:111,824,896...112,202,825
JBrowse link
dichlorine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX12 arachidonate 12-lipoxygenase, 12S type decreases expression EXP Chlorine results in decreased expression of ALOX12 mRNA CTD PMID:22533443 NCBI chr12:52,401,861...52,414,913
Ensembl chr12:52,401,810...52,414,903
JBrowse link
G CCL2 chemokine (C-C motif) ligand 2 increases expression EXP Chlorine results in increased expression of CCL2 mRNA CTD PMID:22533443 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026
JBrowse link
G CCR1 C-C motif chemokine receptor 1 increases expression EXP Chlorine results in increased expression of CCR1 mRNA CTD PMID:22533443 NCBI chr13:29,227,218...29,233,862
Ensembl chr13:29,227,222...29,233,960
JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 increases expression EXP Chlorine results in increased expression of CXCL8 mRNA CTD PMID:22533443 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861
JBrowse link
G EDN1 endothelin 1 increases expression EXP Chlorine results in increased expression of EDN1 protein CTD PMID:16625121 NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348
JBrowse link
G FGFR2 fibroblast growth factor receptor 2 decreases expression EXP Chlorine results in decreased expression of FGFR2 mRNA CTD PMID:22533443 NCBI chr14:131,183,095...131,285,001
Ensembl chr14:131,181,713...131,289,425
JBrowse link
G FOS Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP Chlorine results in increased expression of FOS mRNA CTD PMID:22533443 NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554
JBrowse link
G ICAM1 intercellular adhesion molecule 1 increases expression EXP Chlorine results in increased expression of ICAM1 mRNA CTD PMID:22533443 NCBI chr 2:69,097,136...69,107,722
Ensembl chr 2:69,097,122...69,108,205
JBrowse link
G IL1A interleukin 1 alpha decreases expression EXP Chlorine results in decreased expression of IL1A mRNA CTD PMID:22533443 NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,119
JBrowse link
G IL1R1 interleukin 1 receptor type 1 increases expression EXP Chlorine results in increased expression of IL1R1 mRNA CTD PMID:22533443 NCBI chr 3:52,192,912...52,334,734
Ensembl chr 3:52,192,915...52,288,485
JBrowse link
G IL6 interleukin 6 increases expression EXP Chlorine results in increased expression of IL6 mRNA CTD PMID:22533443 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263
JBrowse link
G LOC110258578 interleukin-1 beta-like increases expression EXP Chlorine results in increased expression of IL1B mRNA CTD PMID:22533443
G SELE selectin E increases expression EXP Chlorine results in increased expression of SELE mRNA CTD PMID:22533443 NCBI chr 4:81,289,061...81,299,657 JBrowse link
G TNFRSF12A TNF receptor superfamily member 12A increases expression EXP Chlorine results in increased expression of TNFRSF12A mRNA CTD PMID:22533443 NCBI chr 3:39,166,288...39,168,294
Ensembl chr 3:39,166,298...39,168,302
JBrowse link
methoctramine tetrahydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRM2 cholinergic receptor muscarinic 2 multiple interactions EXP methoctramine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM2 protein] CTD PMID:8744975 NCBI chr18:12,455,139...12,600,314
Ensembl chr18:12,455,145...12,600,186
JBrowse link
sodium iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC5A5 solute carrier family 5 member 5 multiple interactions
increases uptake
EXP sodium perchlorate inhibits the reaction [SLC5A5 protein alternative form results in increased uptake of Sodium Iodide]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]
SLC5A5 protein alternative form results in increased uptake of Sodium Iodide; SLC5A5 protein results in increased uptake of Sodium Iodide
CTD PMID:12586784 NCBI chr 2:59,869,157...59,885,086
Ensembl chr 2:59,869,155...59,885,266
JBrowse link
zinc dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PSP-I porcine seminal protein I multiple interactions
affects folding
EXP zinc chloride promotes the reaction [PSP-I protein binds to Heparin]
zinc chloride affects the folding of PSP-I protein
CTD PMID:16819821 NCBI chr14:132,302,376...132,309,388
Ensembl chr14:132,302,352...132,308,106
JBrowse link

Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 5059
    chemical entity 5059
      molecular entity 5058
        elemental molecular entity 154
          elemental halogen 60
            elemental bromine + 36
            elemental chlorine + 27
            elemental fluorine + 0
            elemental iodine + 1
paths to the root