halogen oxoacid - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	halogen oxoacid	go back to main search page
Accession:	CHEBI:33425	browse the term
Synonyms:	related_synonym:	halogen oxoacids

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Rat (397) Mouse (402) Human (399) Chinchilla (0) Bonobo (0) Dog (0) Squirrel (0) Pig (1) Green Monkey (0) Naked Mole-rat (0) All
Genes (399)

chloric acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carbonic anhydrase 1

decreases activity

chloric acid results in decreased activity of CA1 protein

NCBI chr 8:85,327,608...85,378,113
Ensembl chr 8:85,327,608...85,379,014

G

carbonic anhydrase 2

decreases activity

chloric acid results in decreased activity of CA2 protein

NCBI chr 8:85,464,007...85,481,493
Ensembl chr 8:85,463,968...85,481,493

G

carbonic anhydrase 4

decreases activity

chloric acid results in decreased activity of CA4 protein

NCBI chr17:60,149,973...60,179,021
Ensembl chr17:60,149,942...60,170,899

G

carbonic anhydrase 5A

decreases activity

chloric acid results in decreased activity of CA5A protein

NCBI chr16:87,881,549...87,936,529
Ensembl chr16:87,881,546...87,936,580

G

carbonic anhydrase 9

decreases activity

chloric acid results in decreased activity of CA9 protein

NCBI chr 9:35,673,928...35,681,159
Ensembl chr 9:35,673,928...35,681,159

G

catalase

decreases activity

chloric acid results in decreased activity of CAT protein

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

glutathione-disulfide reductase

decreases activity

chloric acid results in decreased activity of GSR protein

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

hypochlorous acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1 (ABCC1 blood group)

increases expression

Hypochlorous Acid results in increased expression of ABCC1 mRNA

NCBI chr16:15,949,143...16,143,053
Ensembl chr16:15,949,138...16,143,257

G

ATP binding cassette subfamily D member 1

decreases expression

Hypochlorous Acid results in decreased expression of ABCD1 mRNA

NCBI chr X:153,724,856...153,744,755
Ensembl chr X:153,724,856...153,744,755

G

abhydrolase domain containing 16A, phospholipase

decreases expression

Hypochlorous Acid results in decreased expression of ABHD16A mRNA

NCBI chr 6:31,686,955...31,703,324
Ensembl chr 6:31,686,955...31,703,356

G

acyl-CoA dehydrogenase short chain

decreases expression

Hypochlorous Acid results in decreased expression of ACADS mRNA

NCBI chr12:120,725,826...120,740,008
Ensembl chr12:120,725,774...120,740,008

G

acyl-CoA binding domain containing 4

decreases expression

Hypochlorous Acid results in decreased expression of ACBD4 mRNA

NCBI chr17:45,131,597...45,144,176
Ensembl chr17:45,132,600...45,144,181

G

acetylcholinesterase (Yt blood group)

multiple interactions
decreases activity

[Hypochlorous Acid co-treated with Sodium Nitrite] results in decreased activity of ACHE protein; Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of ACHE protein]

PMID:12414318 PMID:36924976

NCBI chr 7:100,889,994...100,896,994
Ensembl chr 7:100,889,994...100,896,974

G

ADRM1 26S proteasome ubiquitin receptor

increases expression

Hypochlorous Acid results in increased expression of ADRM1 mRNA

NCBI chr20:62,302,896...62,308,862
Ensembl chr20:62,302,093...62,308,862

G

alpha fetoprotein

increases expression

Hypochlorous Acid results in increased expression of AFP mRNA

NCBI chr 4:73,436,221...73,456,174
Ensembl chr 4:73,431,138...73,456,174

G

agrin

decreases expression

Hypochlorous Acid results in decreased expression of AGRN mRNA

NCBI chr 1:1,020,120...1,056,116
Ensembl chr 1:1,020,120...1,056,118

G

aldo-keto reductase family 1 member A1

increases expression

Hypochlorous Acid results in increased expression of AKR1A1 mRNA

NCBI chr 1:45,550,826...45,570,049
Ensembl chr 1:45,550,543...45,570,049

G

aldo-keto reductase family 1 member B

increases expression

Hypochlorous Acid results in increased expression of AKR1B1 mRNA

NCBI chr 7:134,442,350...134,459,239
Ensembl chr 7:134,442,356...134,459,284

G

aldo-keto reductase family 7 member A2

decreases expression

Hypochlorous Acid results in decreased expression of AKR7A5 mRNA

NCBI chr 1:19,302,708...19,312,146
Ensembl chr 1:19,303,965...19,312,144

G

aldehyde dehydrogenase 1 family member A3

increases expression

Hypochlorous Acid results in increased expression of ALDH1A3 mRNA

NCBI chr15:100,879,831...100,916,626
Ensembl chr15:100,877,714...100,916,626

G

angiomotin like 1

decreases expression

Hypochlorous Acid results in decreased expression of AMOTL1 mRNA

NCBI chr11:94,706,460...94,876,748
Ensembl chr11:94,706,431...94,876,748

G

adenosine monophosphate deaminase 1

increases activity
multiple interactions

Hypochlorous Acid results in increased activity of AMPD1 protein
Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of AMPD1 protein]

NCBI chr 1:114,673,098...114,695,546
Ensembl chr 1:114,673,090...114,695,618

G

angel homolog 2

increases expression

Hypochlorous Acid results in increased expression of ANGEL2 mRNA

NCBI chr 1:212,992,182...213,015,867
Ensembl chr 1:212,992,182...213,015,867

G

ankyrin repeat and IBR domain containing 1

increases expression

Hypochlorous Acid results in increased expression of ANKIB1 mRNA

NCBI chr 7:92,245,974...92,401,383
Ensembl chr 7:92,245,974...92,401,383

G

ankyrin repeat domain containing 11

decreases expression

Hypochlorous Acid results in decreased expression of ANKRD11 mRNA

NCBI chr16:89,267,630...89,490,561
Ensembl chr16:89,267,630...89,490,561

G

ankyrin repeat domain 13D

decreases expression

Hypochlorous Acid results in decreased expression of ANKRD13D mRNA

NCBI chr11:67,289,303...67,302,484
Ensembl chr11:67,289,300...67,302,485

G

adaptor related protein complex 1 subunit gamma 2

decreases expression

Hypochlorous Acid results in decreased expression of AP1G2 mRNA

NCBI chr14:23,559,567...23,567,791
Ensembl chr14:23,559,565...23,568,070

G

adaptor related protein complex 3 subunit sigma 2

decreases expression

Hypochlorous Acid results in decreased expression of AP3S2 mRNA

NCBI chr15:89,830,599...89,893,994
Ensembl chr15:89,830,599...89,894,638

G

acylaminoacyl-peptide hydrolase

decreases expression

Hypochlorous Acid results in decreased expression of APEH mRNA

NCBI chr 3:49,673,117...49,683,971
Ensembl chr 3:49,674,014...49,683,971

G

apurinic/apyrimidinic endodeoxyribonuclease 1

multiple interactions
increases activity
increases expression

Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of APEX1 protein]
Hypochlorous Acid results in increased activity of APEX1 protein

NCBI chr14:20,455,226...20,457,767
Ensembl chr14:20,455,191...20,457,772

G

apoptosis inhibitor 5

increases expression

Hypochlorous Acid results in increased expression of API5 mRNA

NCBI chr11:43,311,996...43,344,529
Ensembl chr11:43,311,963...43,344,529

G

apolipoprotein A1

multiple interactions

[Hypochlorous Acid results in increased oxidation of [APOA1 protein binds to Lipids]] which results in decreased activity of LCAT protein; Hypochlorous Acid results in increased oxidation of [APOA1 protein binds to Lipids]

NCBI chr11:116,835,751...116,837,950
Ensembl chr11:116,835,751...116,837,622

G

amyloid beta precursor protein binding protein 2

increases expression

Hypochlorous Acid results in increased expression of APPBP2 mRNA

NCBI chr17:60,443,158...60,526,242
Ensembl chr17:60,443,158...60,526,242

G

archain 1

increases expression

Hypochlorous Acid results in increased expression of ARCN1 mRNA

NCBI chr11:118,572,409...118,603,033
Ensembl chr11:118,572,390...118,603,033

G

Rho GTPase activating protein 24

decreases expression

Hypochlorous Acid results in decreased expression of ARHGAP24 mRNA

NCBI chr 4:85,475,150...86,002,666
Ensembl chr 4:85,475,150...86,002,668

G

Rho guanine nucleotide exchange factor 1

decreases expression

Hypochlorous Acid results in decreased expression of ARHGEF1 mRNA

NCBI chr19:41,883,184...41,930,141
Ensembl chr19:41,883,173...41,930,150

G

ariadne RBR E3 ubiquitin protein ligase 1

increases expression

Hypochlorous Acid results in increased expression of ARIH1 mRNA

NCBI chr15:72,474,330...72,602,987
Ensembl chr15:72,474,330...72,602,987

G

ADP ribosylation factor like GTPase 2

decreases expression

Hypochlorous Acid results in decreased expression of ARL2 mRNA

NCBI chr11:65,014,160...65,022,184
Ensembl chr11:65,014,160...65,022,184

G

ataxin 3

increases expression

Hypochlorous Acid results in increased expression of ATXN3 mRNA

NCBI chr14:92,044,775...92,106,582
Ensembl chr14:92,044,496...92,106,621

G

beta-1,3-glucuronyltransferase 3

decreases expression

Hypochlorous Acid results in decreased expression of B3GAT3 mRNA

NCBI chr11:62,615,296...62,621,986
Ensembl chr11:62,615,296...62,622,154

G

beta-secretase 1

decreases expression

Hypochlorous Acid results in decreased expression of BACE1 mRNA

NCBI chr11:117,285,698...117,316,256
Ensembl chr11:117,285,232...117,316,259

G

branched chain keto acid dehydrogenase kinase

decreases expression

Hypochlorous Acid results in decreased expression of BCKDK mRNA

NCBI chr16:31,108,386...31,117,640
Ensembl chr16:31,106,107...31,112,791

G

BCL2 associated transcription factor 1

increases expression

Hypochlorous Acid results in increased expression of BCLAF1 mRNA

NCBI chr 6:136,256,627...136,289,846
Ensembl chr 6:136,256,627...136,289,851

G

basic helix-loop-helix family member e40

decreases expression

Hypochlorous Acid results in decreased expression of BHLHE40 mRNA

NCBI chr 3:4,979,437...4,985,323
Ensembl chr 3:4,979,437...4,985,323

G

biliverdin reductase B

increases expression

Hypochlorous Acid results in increased expression of BLVRB mRNA

NCBI chr19:40,447,768...40,465,745
Ensembl chr19:40,447,765...40,465,764

G

bromodomain containing 4

decreases expression

Hypochlorous Acid results in decreased expression of BRD4 mRNA

NCBI chr19:15,235,519...15,332,539
Ensembl chr19:15,235,519...15,332,545

G

bromodomain containing 8

decreases expression

Hypochlorous Acid results in decreased expression of BRD8 mRNA

NCBI chr 5:138,139,770...138,178,630
Ensembl chr 5:138,139,770...138,178,953

G

brain protein I3

decreases expression

Hypochlorous Acid results in decreased expression of BRI3 mRNA

NCBI chr 7:98,281,686...98,323,430
Ensembl chr 7:98,252,379...98,310,441

G

BRMS1 transcriptional repressor and anoikis regulator

decreases expression

Hypochlorous Acid results in decreased expression of BRMS1 mRNA

NCBI chr11:66,337,339...66,345,104
Ensembl chr11:66,337,333...66,345,125

G

BTB domain containing 2

decreases expression

Hypochlorous Acid results in decreased expression of BTBD2 mRNA

NCBI chr19:1,985,448...2,015,714
Ensembl chr19:1,985,438...2,034,881

G

basic leucine zipper and W2 domains 1

increases expression

Hypochlorous Acid results in increased expression of BZW1 mRNA

NCBI chr 2:200,811,589...200,827,338
Ensembl chr 2:200,810,594...200,827,338

G

carbonic anhydrase 12

decreases expression

Hypochlorous Acid results in decreased expression of CAR12 mRNA

NCBI chr15:63,321,378...63,381,846
Ensembl chr15:63,321,378...63,381,846

G

calcium binding protein 39

increases expression

Hypochlorous Acid results in increased expression of CAB39 mRNA

NCBI chr 2:230,712,842...230,821,075
Ensembl chr 2:230,712,842...230,821,075

G

calcium/calmodulin dependent protein kinase ID

increases expression

Hypochlorous Acid results in increased expression of CAMK1D mRNA

NCBI chr10:12,349,547...12,835,545
Ensembl chr10:12,349,547...12,835,545

G

calnexin

increases expression

Hypochlorous Acid results in increased expression of CANX mRNA

NCBI chr 5:179,678,656...179,731,641
Ensembl chr 5:179,678,628...179,731,641

G

calpain 5

decreases expression

Hypochlorous Acid results in decreased expression of CAPN5 mRNA

NCBI chr11:77,066,971...77,126,155
Ensembl chr11:77,066,961...77,126,155

G

catalase

multiple interactions
increases activity
increases expression

CAT protein modified form inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]; CAT protein modified form inhibits the reaction [Hypochlorous Acid results in increased expression of NFE2L2 mRNA]
Hypochlorous Acid results in increased activity of CAT protein
Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of CAT protein]
Hypochlorous Acid results in increased expression of CAT mRNA

PMID:17980396 PMID:19376150 PMID:36924976

NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060

G

cyclin D3

decreases expression

Hypochlorous Acid results in decreased expression of CCND3 mRNA

NCBI chr 6:41,934,933...42,050,035
Ensembl chr 6:41,934,934...42,050,357

G

CD47 molecule

decreases expression

Hypochlorous Acid results in decreased expression of CD47 mRNA

NCBI chr 3:108,043,091...108,091,031
Ensembl chr 3:108,043,091...108,091,862

G

cell division cycle 42

increases expression

Hypochlorous Acid results in increased expression of CDC42 mRNA

NCBI chr 1:22,052,709...22,101,360
Ensembl chr 1:22,052,627...22,101,360

G

cell division cycle associated 7 like

decreases expression

Hypochlorous Acid results in decreased expression of CDCA7L mRNA

NCBI chr 7:21,900,899...21,945,899
Ensembl chr 7:21,900,899...21,945,903

G

CDK5 regulatory subunit associated protein 3

decreases expression

Hypochlorous Acid results in decreased expression of CDK5RAP3 mRNA

NCBI chr17:47,967,904...47,981,781
Ensembl chr17:47,967,810...47,981,781

G

cyclin dependent kinase 6

decreases expression

Hypochlorous Acid results in decreased expression of CDK6 mRNA

NCBI chr 7:92,604,921...92,836,573
Ensembl chr 7:92,604,921...92,836,573

G

cyclin dependent kinase 7

increases expression

Hypochlorous Acid results in increased expression of CDK7 mRNA

NCBI chr 5:69,234,795...69,277,430
Ensembl chr 5:69,234,795...69,277,430

G

CDP-diacylglycerol synthase 1

decreases expression

Hypochlorous Acid results in decreased expression of CDS1 mRNA

NCBI chr 4:84,583,127...84,651,334
Ensembl chr 4:84,583,127...84,651,334

G

CDP-diacylglycerol synthase 2

increases expression

Hypochlorous Acid results in increased expression of CDS2 mRNA

NCBI chr20:5,127,008...5,197,887
Ensembl chr20:5,126,879...5,197,887

G

centrosomal protein 43

decreases expression

Hypochlorous Acid results in decreased expression of CEP43 mRNA

NCBI chr 6:166,999,397...167,052,718
Ensembl chr 6:166,999,174...167,052,718

G

centrosomal protein 76

increases expression

Hypochlorous Acid results in increased expression of CEP76 mRNA

NCBI chr18:12,661,956...12,702,777
Ensembl chr18:12,661,833...12,702,777

G

ceramide kinase

decreases expression

Hypochlorous Acid results in decreased expression of CERK mRNA

NCBI chr22:46,684,410...46,738,252
Ensembl chr22:46,684,410...46,738,252

G

chromodomain helicase DNA binding protein 3

decreases expression

Hypochlorous Acid results in decreased expression of CHD3 mRNA

NCBI chr17:7,884,796...7,912,755
Ensembl chr17:7,884,796...7,912,760

G

chromodomain helicase DNA binding protein 4

decreases expression

Hypochlorous Acid results in decreased expression of CHD4 mRNA

NCBI chr12:6,570,082...6,607,379
Ensembl chr12:6,570,082...6,614,524

G

chitinase 1

decreases expression

Hypochlorous Acid results in decreased expression of CHIT1 mRNA

NCBI chr 1:203,216,079...203,230,099
Ensembl chr 1:203,212,827...203,273,641

G

cysteine and histidine rich domain containing 1

increases expression

Hypochlorous Acid results in increased expression of CHORDC1 mRNA

NCBI chr11:90,200,429...90,223,049
Ensembl chr11:90,200,429...90,223,077

G

C-type lectin domain family 4 member D

increases expression

Hypochlorous Acid results in increased expression of CLEC4D mRNA

NCBI chr12:8,513,503...8,531,696
Ensembl chr12:8,509,475...8,522,366

G

CLN6 transmembrane ER protein

decreases expression

Hypochlorous Acid results in decreased expression of CLN6 mRNA

NCBI chr15:68,206,992...68,257,211
Ensembl chr15:68,206,992...68,257,211

G

clathrin light chain A

decreases expression

Hypochlorous Acid results in decreased expression of CLTA mRNA

NCBI chr 9:36,190,874...36,212,059
Ensembl chr 9:36,190,856...36,304,781

G

coronin 1A

decreases expression

Hypochlorous Acid results in decreased expression of CORO1A mRNA

NCBI chr16:30,183,602...30,189,076
Ensembl chr16:30,182,827...30,189,076

G

CTD small phosphatase 1

decreases expression

Hypochlorous Acid results in decreased expression of CTDSP1 mRNA

NCBI chr 2:218,396,351...218,405,941
Ensembl chr 2:218,397,136...218,405,941

G

catenin beta interacting protein 1

decreases expression

Hypochlorous Acid results in decreased expression of CTNNBIP1 mRNA

NCBI chr 1:9,848,276...9,910,269
Ensembl chr 1:9,848,276...9,910,336

G

cystinosin, lysosomal cystine transporter

decreases expression

Hypochlorous Acid results in decreased expression of CTNS mRNA

NCBI chr17:3,636,459...3,663,103
Ensembl chr17:3,636,459...3,663,103

G

cathepsin B

decreases expression

Hypochlorous Acid results in decreased expression of CTSB mRNA

NCBI chr 8:11,842,524...11,868,087
Ensembl chr 8:11,842,524...11,869,533

G

cullin 5

increases expression

Hypochlorous Acid results in increased expression of CUL5 mRNA

NCBI chr11:108,008,898...108,107,761
Ensembl chr11:108,008,898...108,107,761

G

cytochrome P450 family 20 subfamily A member 1

increases expression

Hypochlorous Acid results in increased expression of CYP20A1 mRNA

NCBI chr 2:203,239,018...203,306,026
Ensembl chr 2:203,238,977...203,306,026

G

DAB adaptor protein 2

decreases expression

Hypochlorous Acid results in decreased expression of DAB2 mRNA

NCBI chr 5:39,371,677...39,424,980
Ensembl chr 5:39,371,675...39,462,300

G

DNA damage inducible transcript 3

increases expression

Hypochlorous Acid results in increased expression of DDIT3 mRNA

NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737

G

DEAD-box helicase 10

increases expression

Hypochlorous Acid results in increased expression of DDX10 mRNA

NCBI chr11:108,665,069...108,940,927
Ensembl chr11:108,665,058...108,940,999

G

DEAD-box helicase 3 X-linked

increases expression

Hypochlorous Acid results in increased expression of DDX3X mRNA

NCBI chr X:41,333,308...41,364,472
Ensembl chr X:41,333,348...41,364,472

G

DENN domain containing 1A

decreases expression

Hypochlorous Acid results in decreased expression of DENND1A mRNA

NCBI chr 9:123,379,658...123,930,126
Ensembl chr 9:123,379,654...123,930,152

G

DEAH-box helicase 33

increases expression

Hypochlorous Acid results in increased expression of DHX33 mRNA

NCBI chr17:5,440,917...5,468,982
Ensembl chr17:5,440,917...5,468,982

G

dihydrolipoamide S-succinyltransferase

decreases expression

Hypochlorous Acid results in decreased expression of DLST mRNA

NCBI chr14:74,881,916...74,903,743
Ensembl chr14:74,881,891...74,903,743

G

DnaJ heat shock protein family (Hsp40) member A2

increases expression

Hypochlorous Acid results in increased expression of DNAJA2 mRNA

NCBI chr16:46,955,362...46,973,674
Ensembl chr16:46,955,362...46,973,674

G

DNA methyltransferase 1

decreases expression

Hypochlorous Acid results in decreased expression of DNMT1 mRNA

NCBI chr19:10,133,346...10,194,953
Ensembl chr19:10,133,342...10,231,286

G

DNA methyltransferase 3 like

increases expression

Hypochlorous Acid results in increased expression of DNMT3L mRNA

NCBI chr21:44,246,339...44,261,897
Ensembl chr21:44,246,339...44,262,216

G

deoxynucleotidyltransferase terminal interacting protein 2

increases expression

Hypochlorous Acid results in increased expression of DNTTIP2 mRNA

NCBI chr 1:93,866,284...93,879,206
Ensembl chr 1:93,866,284...93,879,918

G

down-regulator of transcription 1

increases expression

Hypochlorous Acid results in increased expression of DR1 mRNA

NCBI chr 1:93,345,907...93,369,493
Ensembl chr 1:93,345,907...93,369,493

G

dystrobrevin beta

decreases expression

Hypochlorous Acid results in decreased expression of DTNB mRNA

NCBI chr 2:25,377,243...25,673,577
Ensembl chr 2:25,377,198...25,673,647

G

DTW domain containing 2

increases expression

Hypochlorous Acid results in increased expression of DTWD2 mRNA

NCBI chr 5:118,836,074...118,988,547
Ensembl chr 5:118,836,074...118,988,547

G

deltex E3 ubiquitin ligase 3

decreases expression

Hypochlorous Acid results in decreased expression of DTX3 mRNA

NCBI chr12:57,604,824...57,609,802
Ensembl chr12:57,604,622...57,609,804

G

eukaryotic elongation factor, selenocysteine-tRNA specific

decreases expression

Hypochlorous Acid results in decreased expression of EEFSEC mRNA

NCBI chr 3:128,153,481...128,426,223
Ensembl chr 3:128,153,481...128,408,646

G

epidermal growth factor receptor

multiple interactions

Hypochlorous Acid results in increased phosphorylation of and results in increased activity of EGFR protein

NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628

G

euchromatic histone lysine methyltransferase 2

decreases expression

Hypochlorous Acid results in decreased expression of EHMT2 mRNA

NCBI chr 6:31,879,759...31,897,698
Ensembl chr 6:31,879,759...31,897,698

G

eukaryotic translation initiation factor 5

increases expression

Hypochlorous Acid results in increased expression of EIF5 mRNA

NCBI chr14:103,334,237...103,345,025
Ensembl chr14:103,333,544...103,345,025

G

elongin A

increases expression

Hypochlorous Acid results in increased expression of ELOA mRNA

NCBI chr 1:23,743,471...23,762,059
Ensembl chr 1:23,743,448...23,762,059

G

ERI1 exoribonuclease family member 3

decreases expression

Hypochlorous Acid results in decreased expression of ERI3 mRNA

NCBI chr 1:44,221,070...44,355,279
Ensembl chr 1:44,221,070...44,355,260

G

endoplasmic reticulum protein 29

decreases expression

Hypochlorous Acid results in decreased expression of ERP29 mRNA

NCBI chr12:112,013,426...112,023,449
Ensembl chr12:112,013,348...112,023,449

G

establishment of sister chromatid cohesion N-acetyltransferase 1

increases expression

Hypochlorous Acid results in increased expression of ESCO1 mRNA

NCBI chr18:21,529,284...21,600,704
Ensembl chr18:21,529,284...21,600,884

G

esterase D

increases expression

Hypochlorous Acid results in increased expression of ESD mRNA

NCBI chr13:46,771,256...46,797,700
Ensembl chr13:46,771,256...46,797,420

G

exosome component 5

decreases expression

Hypochlorous Acid results in decreased expression of EXOSC5 mRNA

NCBI chr19:41,386,374...41,397,359
Ensembl chr19:41,386,371...41,397,362

G

FA complementation group E

decreases expression

Hypochlorous Acid results in decreased expression of FANCE mRNA

NCBI chr 6:35,452,338...35,467,102
Ensembl chr 6:35,452,338...35,467,104

G

Fas activated serine/threonine kinase

decreases expression

Hypochlorous Acid results in decreased expression of FASTK mRNA

NCBI chr 7:151,076,624...151,080,809
Ensembl chr 7:151,076,624...151,080,866

G

F-box and leucine rich repeat protein 3

increases expression

Hypochlorous Acid results in increased expression of FBXL3 mRNA

NCBI chr13:77,005,260...77,027,159
Ensembl chr13:76,992,598...77,027,195

G

F-box and WD repeat domain containing 5

decreases expression

Hypochlorous Acid results in decreased expression of FBXW5 mRNA

NCBI chr 9:136,940,435...136,944,738
Ensembl chr 9:136,940,435...136,944,738

G

F-box and WD repeat domain containing 7

decreases expression

Hypochlorous Acid results in decreased expression of FBXW7 mRNA

NCBI chr 4:152,320,544...152,536,092
Ensembl chr 4:152,320,544...152,536,092

G

FGR proto-oncogene, Src family tyrosine kinase

decreases expression

Hypochlorous Acid results in decreased expression of FGR mRNA

NCBI chr 1:27,612,064...27,635,185
Ensembl chr 1:27,612,064...27,635,185

G

fukutin

increases expression

Hypochlorous Acid results in increased expression of FKTN mRNA

NCBI chr 9:105,558,130...105,641,118
Ensembl chr 9:105,558,122...105,653,820

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Hypochlorous Acid results in increased expression of FOS mRNA; Hypochlorous Acid results in increased expression of FOS protein

NCBI chr14:75,278,828...75,282,230
Ensembl chr14:75,278,826...75,282,230

G

FAD dependent oxidoreductase domain containing 1

decreases expression

Hypochlorous Acid results in decreased expression of FOXRED1 mRNA

NCBI chr11:126,269,154...126,278,126
Ensembl chr11:126,269,024...126,278,131

G

ferritin light chain

increases expression

Hypochlorous Acid results in increased expression of FTL1 mRNA

NCBI chr19:48,965,309...48,966,879
Ensembl chr19:48,965,309...48,966,879

G

glucose-6-phosphate dehydrogenase

decreases activity
multiple interactions

Hypochlorous Acid results in decreased activity of G6PD protein
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of G6PD protein]

NCBI chr X:154,531,390...154,547,569
Ensembl chr X:154,517,825...154,547,572

G

growth arrest and DNA damage inducible alpha

increases expression

Hypochlorous Acid results in increased expression of GADD45A mRNA

NCBI chr 1:67,685,201...67,688,334
Ensembl chr 1:67,685,201...67,688,334

G

growth arrest and DNA damage inducible beta

increases expression

Hypochlorous Acid results in increased expression of GADD45B mRNA

NCBI chr19:2,476,127...2,478,257
Ensembl chr19:2,476,122...2,478,259

G

growth arrest and DNA damage inducible gamma

increases expression

Hypochlorous Acid results in increased expression of GADD45G mRNA

NCBI chr 9:89,605,012...89,606,555
Ensembl chr 9:89,605,012...89,606,555

G

galactokinase 1

decreases expression

Hypochlorous Acid results in decreased expression of GALK1 mRNA

NCBI chr17:75,751,469...75,765,192
Ensembl chr17:75,751,594...75,765,236

G

glutamate-cysteine ligase catalytic subunit

multiple interactions
affects expression
increases expression

Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]; Buthionine Sulfoximine inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]; CAT protein modified form inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]; S-ethyl glutathione inhibits the reaction [Hypochlorous Acid results in increased expression of GCLC mRNA]
Hypochlorous Acid affects the expression of GCLC mRNA

PMID:17980396 PMID:18648578

NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970

G

glutamate-cysteine ligase modifier subunit

increases expression

Hypochlorous Acid results in increased expression of GCLM mRNA

PMID:18156441 PMID:19376150

NCBI chr 1:93,885,199...93,909,430
Ensembl chr 1:93,885,199...93,909,456

G

glia maturation factor beta

increases expression

Hypochlorous Acid results in increased expression of GMFB mRNA

NCBI chr14:54,474,485...54,488,980
Ensembl chr14:54,474,484...54,489,025

G

G protein subunit alpha i3

increases expression

Hypochlorous Acid results in increased expression of GNAI3 mRNA

NCBI chr 1:109,548,615...109,600,195
Ensembl chr 1:109,548,615...109,600,195

G

G protein subunit beta 2

decreases expression

Hypochlorous Acid results in decreased expression of GNB2 mRNA

NCBI chr 7:100,673,740...100,679,169
Ensembl chr 7:100,673,567...100,679,174

G

golgi associated PDZ and coiled-coil motif containing

increases expression

Hypochlorous Acid results in increased expression of GOPC mRNA

NCBI chr 6:117,560,269...117,602,511
Ensembl chr 6:117,560,269...117,602,542

G

GC-rich promoter binding protein 1

increases expression

Hypochlorous Acid results in increased expression of GPBP1 mRNA

NCBI chr 5:57,174,059...57,264,679
Ensembl chr 5:57,173,948...57,264,679

G

glutathione peroxidase 1

decreases expression
multiple interactions
increases activity

Hypochlorous Acid results in decreased expression of GPX1 mRNA
Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of GPX1 protein]

PMID:19376150 PMID:36924976

NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605

G

glutathione peroxidase 4

decreases expression

Hypochlorous Acid results in decreased expression of GPX4 mRNA

NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,982...1,106,791

G

granulin precursor

decreases expression

Hypochlorous Acid results in decreased expression of GRN mRNA

NCBI chr17:44,345,302...44,353,106
Ensembl chr17:44,345,246...44,353,106

G

glutathione-disulfide reductase

increases expression
decreases activity
multiple interactions

Hypochlorous Acid results in increased expression of GSR mRNA
Hypochlorous Acid results in decreased activity of GSR protein
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of GSR protein]

PMID:17980396 PMID:36924976

NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846

G

glutathione synthetase

increases expression

Hypochlorous Acid results in increased expression of GSS mRNA

NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027

G

H2B clustered histone 18

increases expression

Hypochlorous Acid results in increased expression of H2BC18 mRNA

NCBI chr 1:149,782,689...149,812,370
Ensembl chr 1:149,782,689...149,812,373

G

hydroxyacylglutathione hydrolase like

decreases expression

Hypochlorous Acid results in decreased expression of HAGHL mRNA

NCBI chr16:727,106...729,715
Ensembl chr16:726,936...735,525

G

HAUS augmin like complex subunit 4

decreases expression

Hypochlorous Acid results in decreased expression of HAUS4 mRNA

NCBI chr14:22,946,228...22,957,090
Ensembl chr14:22,946,228...22,957,161

G

histone deacetylase 10

decreases expression

Hypochlorous Acid results in decreased expression of HDAC10 mRNA

NCBI chr22:50,245,183...50,251,265
Ensembl chr22:50,245,183...50,251,405

G

histone deacetylase 5

decreases expression

Hypochlorous Acid results in decreased expression of HDAC5 mRNA

NCBI chr17:44,076,753...44,123,641
Ensembl chr17:44,076,746...44,123,702

G

histone deacetylase 6

decreases expression

Hypochlorous Acid results in decreased expression of HDAC6 mRNA

NCBI chr X:48,801,398...48,824,982
Ensembl chr X:48,801,377...48,824,982

G

hexosaminidase D

decreases expression

Hypochlorous Acid results in decreased expression of HEXD mRNA

NCBI chr17:82,418,347...82,442,645
Ensembl chr17:82,418,318...82,442,645

G

homeodomain interacting protein kinase 2

increases expression

Hypochlorous Acid results in increased expression of HIPK2 mRNA

NCBI chr 7:139,561,570...139,777,998
Ensembl chr 7:139,561,570...139,777,998

G

homeodomain interacting protein kinase 3

increases expression

Hypochlorous Acid results in increased expression of HIPK3 mRNA

NCBI chr11:33,256,672...33,357,023
Ensembl chr11:33,256,672...33,357,023

G

hexokinase 1

decreases activity
multiple interactions

Hypochlorous Acid results in decreased activity of HK1 protein
Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of HK1 protein]

NCBI chr10:69,270,000...69,401,882
Ensembl chr10:69,269,984...69,401,884

G

high mobility group AT-hook 2

increases expression

Hypochlorous Acid results in increased expression of HMGA2 mRNA

NCBI chr12:65,824,460...65,966,291
Ensembl chr12:65,824,460...65,966,291

G

heme oxygenase 1

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of HMOX1 mRNA]
[Quercetin co-treated with Hypochlorous Acid] results in increased expression of HMOX1 protein
Hypochlorous Acid results in increased expression of HMOX1 mRNA; Hypochlorous Acid results in increased expression of HMOX1 protein

PMID:17980396 PMID:18156441 PMID:19376150 PMID:24017971

NCBI chr22:35,381,096...35,394,207
Ensembl chr22:35,380,361...35,394,214

G

hippocalcin like 1

decreases expression

Hypochlorous Acid results in decreased expression of HPCAL1 mRNA

NCBI chr 2:10,302,904...10,427,604
Ensembl chr 2:10,302,889...10,427,617

G

hypoxanthine phosphoribosyltransferase 1

increases mutagenesis

Hypochlorous Acid results in increased mutagenesis of HPRT1 gene

NCBI chr X:134,460,165...134,500,668
Ensembl chr X:134,460,165...134,520,513

G

HPS1 biogenesis of lysosomal organelles complex 3 subunit 1

decreases expression

Hypochlorous Acid results in decreased expression of HPS1 mRNA

NCBI chr10:98,413,948...98,446,935
Ensembl chr10:98,410,939...98,446,963

G

heat shock protein 90 alpha family class A member 1

increases expression

Hypochlorous Acid results in increased expression of HSP90AA1 mRNA

NCBI chr14:102,080,742...102,139,749
Ensembl chr14:102,080,742...102,139,699

G

heat shock protein family A (Hsp70) member 13

increases expression

Hypochlorous Acid results in increased expression of HSPA13 mRNA

NCBI chr21:14,371,115...14,383,146
Ensembl chr21:14,371,115...14,383,484

G

heat shock protein family A (Hsp70) member 1A

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of HSPA1A protein]

NCBI chr 6:31,815,543...31,817,942
Ensembl chr 6:31,815,543...31,817,946

G

heat shock protein family A (Hsp70) member 1B

increases expression

Hypochlorous Acid results in increased expression of HSPA1B mRNA

NCBI chr 6:31,827,738...31,830,254
Ensembl chr 6:31,827,738...31,830,254

G

interferon gamma

increases expression

Hypochlorous Acid results in increased expression of IFNG mRNA

NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740

G

inhibitor of nuclear factor kappa B kinase regulatory subunit gamma

increases expression

Hypochlorous Acid results in increased expression of IKBKG mRNA

NCBI chr X:154,541,238...154,565,046
Ensembl chr X:154,541,199...154,565,046

G

interleukin 10

increases expression

Hypochlorous Acid results in increased expression of IL10 mRNA

NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541

G

interleukin 1 beta

increases expression

Hypochlorous Acid results in increased expression of IL1B mRNA

NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816

G

interleukin 6

increases expression

Hypochlorous Acid results in increased expression of IL6 mRNA

NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002

G

inhibitor of growth family member 2

decreases expression

Hypochlorous Acid results in decreased expression of ING2 mRNA

NCBI chr 4:183,505,058...183,512,429
Ensembl chr 4:183,505,058...183,512,429

G

integrator complex subunit 7

decreases expression

Hypochlorous Acid results in decreased expression of INTS7 mRNA

NCBI chr 1:211,940,403...212,035,557
Ensembl chr 1:211,940,399...212,035,557

G

integrator complex subunit 8

increases expression

Hypochlorous Acid results in increased expression of INTS8 mRNA

NCBI chr 8:94,823,287...94,881,746
Ensembl chr 8:94,813,311...94,881,746

G

integrin subunit beta 5

decreases expression

Hypochlorous Acid results in decreased expression of ITGB5 mRNA

NCBI chr 3:124,761,948...124,901,418
Ensembl chr 3:124,761,948...124,901,418

G

jagged canonical Notch ligand 1

increases expression

Hypochlorous Acid results in increased expression of JAG1 mRNA

NCBI chr20:10,637,684...10,673,999
Ensembl chr20:10,637,684...10,673,999

G

Janus kinase 3

decreases expression

Hypochlorous Acid results in decreased expression of JAK3 mRNA

NCBI chr19:17,824,782...17,847,982
Ensembl chr19:17,824,780...17,848,071

G

kelch repeat and BTB domain containing 8

increases expression

Hypochlorous Acid results in increased expression of KBTBD8 mRNA

NCBI chr 3:66,998,307...67,011,210
Ensembl chr 3:66,998,307...67,011,210

G

kelch like ECH associated protein 1

increases expression

Hypochlorous Acid results in increased expression of KEAP1 mRNA

NCBI chr19:10,486,125...10,503,356
Ensembl chr19:10,486,125...10,503,558

G

kinesin family member 1B

increases expression

Hypochlorous Acid results in increased expression of KIF1B mRNA

NCBI chr 1:10,210,570...10,381,603
Ensembl chr 1:10,210,570...10,381,603

G

kinesin family member 24

decreases expression

Hypochlorous Acid results in decreased expression of KIF24 mRNA

NCBI chr 9:34,252,380...34,333,671
Ensembl chr 9:34,252,380...34,329,268

G

kinesin family member 3C

increases expression

Hypochlorous Acid results in increased expression of KIF3C mRNA

NCBI chr 2:25,926,598...25,982,497
Ensembl chr 2:25,926,598...25,982,749

G

kinesin family member 5B

increases expression

Hypochlorous Acid results in increased expression of KIF5B mRNA

NCBI chr10:32,009,015...32,056,425
Ensembl chr10:32,009,015...32,056,425

G

karyopherin subunit alpha 1

increases expression

Hypochlorous Acid results in increased expression of KPNA1 mRNA

NCBI chr 3:122,421,902...122,514,939
Ensembl chr 3:122,421,902...122,514,945

G

karyopherin subunit alpha 4

increases expression

Hypochlorous Acid results in increased expression of KPNA4 mRNA

NCBI chr 3:160,495,007...160,565,571
Ensembl chr 3:160,495,007...160,565,571

G

KRR1 small subunit processome component homolog

increases expression

Hypochlorous Acid results in increased expression of KRR1 mRNA

NCBI chr12:75,490,863...75,511,609
Ensembl chr12:75,490,863...75,511,636

G

lecithin-cholesterol acyltransferase

multiple interactions

[Hypochlorous Acid results in increased oxidation of [APOA1 protein binds to Lipids]] which results in decreased activity of LCAT protein

NCBI chr16:67,939,750...67,944,120
Ensembl chr16:67,939,750...67,944,131

G

lactate dehydrogenase A

increases activity
multiple interactions

Hypochlorous Acid results in increased activity of LDHA protein
Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of LDHA protein]

NCBI chr11:18,394,563...18,408,425
Ensembl chr11:18,394,560...18,408,425

G

LIM domain containing 2

decreases expression

Hypochlorous Acid results in decreased expression of LIMD2 mRNA

NCBI chr17:63,695,888...63,701,155
Ensembl chr17:63,695,888...63,701,172

G

lipase maturation factor 1

decreases expression

Hypochlorous Acid results in decreased expression of LMF1 mRNA

NCBI chr16:853,634...981,613
Ensembl chr16:853,634...981,318

G

lysyl oxidase like 3

decreases expression

Hypochlorous Acid results in decreased expression of LOXL3 mRNA

NCBI chr 2:74,532,258...74,555,702
Ensembl chr 2:74,532,258...74,555,690

G

LDL receptor related protein 1

decreases expression

Hypochlorous Acid results in decreased expression of LRP1 mRNA

NCBI chr12:57,128,483...57,213,361
Ensembl chr12:57,128,483...57,213,361

G

leucine rich repeat containing 8 VRAC subunit D

increases expression

Hypochlorous Acid results in increased expression of LRRC8D mRNA

NCBI chr 1:89,821,032...89,936,611
Ensembl chr 1:89,821,014...89,936,611

G

MAF bZIP transcription factor F

increases expression

Hypochlorous Acid results in increased expression of MAFF mRNA

NCBI chr22:38,201,994...38,216,511
Ensembl chr22:38,200,767...38,216,507

G

MAF bZIP transcription factor G

increases expression

Hypochlorous Acid results in increased expression of MAFG mRNA

NCBI chr17:81,918,270...81,931,244
Ensembl chr17:81,918,270...81,927,735

G

mannosidase alpha class 1A member 2

increases expression

Hypochlorous Acid results in increased expression of MAN1A2 mRNA

NCBI chr 1:117,367,449...117,528,872
Ensembl chr 1:117,367,449...117,528,872

G

mannosidase alpha class 1C member 1

decreases expression

Hypochlorous Acid results in decreased expression of MAN1C1 mRNA

NCBI chr 1:25,616,791...25,784,450
Ensembl chr 1:25,616,791...25,784,450

G

mannosidase alpha class 2C member 1

decreases expression

Hypochlorous Acid results in decreased expression of MAN2C1 mRNA

NCBI chr15:75,355,792...75,368,607
Ensembl chr15:75,355,207...75,368,612

G

mitogen-activated protein kinase kinase kinase 7

increases expression

Hypochlorous Acid results in increased expression of MAP3K7 mRNA

NCBI chr 6:90,513,579...90,587,072
Ensembl chr 6:90,513,573...90,587,086

G

mitogen-activated protein kinase kinase kinase kinase 1

decreases expression

Hypochlorous Acid results in decreased expression of MAP4K1 mRNA

NCBI chr19:38,587,641...38,617,953
Ensembl chr19:38,587,641...38,618,882

G

mitogen-activated protein kinase 1

multiple interactions

Hypochlorous Acid results in increased phosphorylation of and results in increased activity of MAPK1 protein

NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680

G

mitogen-activated protein kinase 10

multiple interactions

Hypochlorous Acid results in increased phosphorylation of and results in increased activity of MAPK10 protein

NCBI chr 4:86,010,405...86,594,074
Ensembl chr 4:85,990,007...86,594,625

G

mitogen-activated protein kinase 3

multiple interactions

Hypochlorous Acid results in increased phosphorylation of and results in increased activity of MAPK3 protein

NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506

G

mitogen-activated protein kinase 6

increases expression

Hypochlorous Acid results in increased expression of MAPK6 mRNA

NCBI chr15:51,971,825...52,067,375
Ensembl chr15:51,952,106...52,067,375

G

mitogen-activated protein kinase 8

multiple interactions

Hypochlorous Acid results in increased phosphorylation of and results in increased activity of MAPK8 protein

NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360

G

mitogen-activated protein kinase 9

multiple interactions

Hypochlorous Acid results in increased phosphorylation of and results in increased activity of MAPK9 protein

NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099

G

membrane associated ring-CH-type finger 2

decreases expression

Hypochlorous Acid results in decreased expression of MARCHF2 mRNA

NCBI chr19:8,413,305...8,439,017
Ensembl chr19:8,413,270...8,439,017

G

malic enzyme 1

increases expression

Hypochlorous Acid results in increased expression of ME1 mRNA

NCBI chr 6:83,210,402...83,431,051
Ensembl chr 6:83,210,402...83,431,051

G

microfibril associated protein 1

increases expression

Hypochlorous Acid results in increased expression of MFAP1 mRNA

NCBI chr15:43,804,492...43,824,690
Ensembl chr15:43,804,492...43,824,690

G

major facilitator superfamily domain containing 13A

decreases expression

Hypochlorous Acid results in decreased expression of MFSD13A mRNA

NCBI chr10:102,461,395...102,477,045
Ensembl chr10:102,461,395...102,477,045

G

migration and invasion inhibitory protein

decreases expression

Hypochlorous Acid results in decreased expression of MIIP mRNA

NCBI chr 1:12,019,498...12,032,045
Ensembl chr 1:12,019,466...12,032,045

G

MOB kinase activator 1A

increases expression

Hypochlorous Acid results in increased expression of MOB1A mRNA

NCBI chr 2:74,152,528...74,178,879
Ensembl chr 2:74,152,528...74,178,898

G

myeloperoxidase

multiple interactions
increases abundance
increases chemical synthesis

4-amino-TEMPO inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]; 4-aminobenzhydrazide inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]; [1,6-diaminohexane binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]; [[MPO protein co-treated with Hypochlorous Acid] results in increased oxidation of nimesulide metabolite] which results in increased chemical synthesis of nimesulide metabolite; [Cadaverine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]; [ethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]; [MPO protein co-treated with Hypochlorous Acid] results in increased oxidation of and affects the activity of nimesulide metabolite; [MPO protein results in increased metabolism of chlorodimedone] which results in increased abundance of Hypochlorous Acid; [Putrescine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]; [Spermine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]; [trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]; Clozapine promotes the reaction [[MPO protein results in increased metabolism of chlorodimedone] which results in increased abundance of Hypochlorous Acid]; Clozapine promotes the reaction [MPO protein results in increased abundance of Hypochlorous Acid]; Heparin inhibits the reaction [4-amino-TEMPO inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]; Heparin inhibits the reaction [[1,6-diaminohexane binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]; Heparin inhibits the reaction [[Cadaverine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]; Heparin inhibits the reaction [[Putrescine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]; Heparin inhibits the reaction [[Spermine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]; Heparin inhibits the reaction [[trimethylenediamine binds to TEMPO] inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]]; MitoTEMPO inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]; Quetiapine Fumarate inhibits the reaction [[MPO protein results in increased metabolism of chlorodimedone] which results in increased abundance of Hypochlorous Acid]; Quetiapine Fumarate inhibits the reaction [MPO protein results in increased abundance of Hypochlorous Acid]; TEMPOL-H inhibits the reaction [MPO protein results in increased chemical synthesis of Hypochlorous Acid]

PMID:7772042 PMID:20939553 PMID:34085520 PMID:35575633

NCBI chr17:58,269,855...58,280,935
Ensembl chr17:58,269,855...58,280,935

G

mitochondrial ribosomal protein L4

decreases expression

Hypochlorous Acid results in decreased expression of MRPL4 mRNA

NCBI chr19:10,251,951...10,260,055
Ensembl chr19:10,251,901...10,260,055

G

methionine sulfoxide reductase B1

decreases expression

Hypochlorous Acid results in decreased expression of MSRB1 mRNA

NCBI chr16:1,938,229...1,943,199
Ensembl chr16:1,938,229...1,943,199

G

metastasis associated 1

decreases expression

Hypochlorous Acid results in decreased expression of MTA1 mRNA

NCBI chr14:105,419,827...105,470,729
Ensembl chr14:105,419,820...105,470,729

G

metastasis associated 1 family member 3

decreases expression

Hypochlorous Acid results in decreased expression of MTA3 mRNA

NCBI chr 2:42,494,110...42,756,946
Ensembl chr 2:42,494,569...42,756,947

G

mitochondrial amidoxime reducing component 2

decreases expression

Hypochlorous Acid results in decreased expression of MTARC2 mRNA

NCBI chr 1:220,748,322...220,784,815
Ensembl chr 1:220,748,225...220,784,815

G

metadherin

increases expression

Hypochlorous Acid results in increased expression of MTDH mRNA

NCBI chr 8:97,644,184...97,730,260
Ensembl chr 8:97,644,184...97,730,260

G

myotubularin related protein 6

increases expression

Hypochlorous Acid results in increased expression of MTMR6 mRNA

NCBI chr13:25,246,222...25,287,488
Ensembl chr13:25,246,222...25,287,510

G

myotrophin

increases expression

Hypochlorous Acid results in increased expression of MTPN mRNA

NCBI chr 7:135,926,760...135,977,359
Ensembl chr 7:135,926,760...135,977,359

G

mucin 16, cell surface associated

increases expression

Hypochlorous Acid results in increased expression of MUC16 mRNA

NCBI chr19:8,848,844...9,065,751
Ensembl chr19:8,848,844...9,010,390

G

mevalonate diphosphate decarboxylase

decreases expression

Hypochlorous Acid results in decreased expression of MVD mRNA

NCBI chr16:88,651,940...88,663,091
Ensembl chr16:88,651,935...88,663,161

G

myosin heavy chain 9

decreases expression

Hypochlorous Acid results in decreased expression of MYH9 mRNA

NCBI chr22:36,281,280...36,387,967
Ensembl chr22:36,281,280...36,388,010

G

myosin IF

decreases expression

Hypochlorous Acid results in decreased expression of MYO1F mRNA

NCBI chr19:8,520,778...8,577,442
Ensembl chr19:8,520,778...8,577,442

G

myosin IXB

decreases expression

Hypochlorous Acid results in decreased expression of MYO9B mRNA

NCBI chr19:17,075,777...17,213,286
Ensembl chr19:17,075,777...17,214,537

G

N-alpha-acetyltransferase 15, NatA auxiliary subunit

increases expression

Hypochlorous Acid results in increased expression of NAA15 mRNA

NCBI chr 4:139,301,505...139,391,384
Ensembl chr 4:139,301,446...139,420,033

G

non-SMC condensin II complex subunit H2

decreases expression

Hypochlorous Acid results in decreased expression of NCAPH2 mRNA

NCBI chr22:50,508,224...50,524,780
Ensembl chr22:50,508,224...50,524,780

G

NADH:ubiquinone oxidoreductase core subunit S2

decreases expression

Hypochlorous Acid results in decreased expression of NDUFS2 mRNA

NCBI chr 1:161,197,417...161,214,395
Ensembl chr 1:161,197,104...161,214,723

G

NADH:ubiquinone oxidoreductase core subunit S7

decreases expression

Hypochlorous Acid results in decreased expression of NDUFS7 mRNA

NCBI chr19:1,383,907...1,395,584
Ensembl chr19:1,383,527...1,395,589

G

negative elongation factor complex member E

decreases expression

Hypochlorous Acid results in decreased expression of NELFE mRNA

NCBI chr 6:31,952,087...31,958,971
Ensembl chr 6:31,952,087...31,959,038

G

neural EGFL like 1

decreases expression

Hypochlorous Acid results in decreased expression of NELL1 mRNA

NCBI chr11:20,669,551...21,575,686
Ensembl chr11:20,669,551...21,575,686

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression
affects response to substance

Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of NFE2L2 mRNA]
Hypochlorous Acid results in increased expression of NFE2L2 protein
Acetylcysteine inhibits the reaction [Hypochlorous Acid results in increased expression of NFE2L2 mRNA]; Buthionine Sulfoximine inhibits the reaction [Hypochlorous Acid results in increased expression of NFE2L2 mRNA]; CAT protein modified form inhibits the reaction [Hypochlorous Acid results in increased expression of NFE2L2 mRNA]; S-ethyl glutathione inhibits the reaction [Hypochlorous Acid results in increased expression of NFE2L2 mRNA]
NFE2L2 protein affects the susceptibility to Hypochlorous Acid

PMID:17980396 PMID:18156441

NCBI chr 2:177,230,303...177,264,727
Ensembl chr 2:177,218,667...177,392,756

G

nucleolar protein 11

increases expression

Hypochlorous Acid results in increased expression of NOL11 mRNA

NCBI chr17:67,717,936...67,744,531
Ensembl chr17:67,717,931...67,744,531

G

NAD(P)H quinone dehydrogenase 1

increases expression
affects expression

Hypochlorous Acid results in increased expression of NQO1 mRNA
Hypochlorous Acid affects the expression of NQO1 mRNA

PMID:17980396 PMID:18156441 PMID:18648578 PMID:19376150

NCBI chr16:69,709,401...69,726,560
Ensembl chr16:69,706,996...69,726,668

G

nuclear receptor subfamily 1 group D member 1

decreases expression

Hypochlorous Acid results in decreased expression of NR1D1 mRNA

NCBI chr17:40,092,793...40,100,589
Ensembl chr17:40,092,793...40,100,589

G

neuropilin 1

increases expression

Hypochlorous Acid results in increased expression of NRP1 mRNA

NCBI chr10:33,177,493...33,334,667
Ensembl chr10:33,177,492...33,336,262

G

nucleoporin 54

increases expression

Hypochlorous Acid results in increased expression of NUP54 mRNA

NCBI chr 4:76,114,664...76,148,397
Ensembl chr 4:76,107,562...76,148,485

G

OTU deubiquitinase 4

increases expression

Hypochlorous Acid results in increased expression of OTUD4 mRNA

NCBI chr 4:145,133,650...145,180,589
Ensembl chr 4:145,110,838...145,180,589

G

oviductal glycoprotein 1

decreases expression

Hypochlorous Acid results in decreased expression of OVGP1 mRNA

NCBI chr 1:111,414,319...111,427,735
Ensembl chr 1:111,414,319...111,427,735

G

prolyl 3-hydroxylase 3

decreases expression

Hypochlorous Acid results in decreased expression of P3H3 mRNA

NCBI chr12:6,828,407...6,839,847
Ensembl chr12:6,828,407...6,839,847

G

protein kinase C and casein kinase substrate in neurons 3

increases expression

Hypochlorous Acid results in increased expression of PACSIN3 mRNA

NCBI chr11:47,177,522...47,186,434
Ensembl chr11:47,177,522...47,186,443

G

platelet activating factor acetylhydrolase 1b catalytic subunit 2

increases expression

Hypochlorous Acid results in increased expression of PAFAH1B2 mRNA

NCBI chr11:117,144,287...117,178,173
Ensembl chr11:117,144,284...117,176,894

G

PAK1 interacting protein 1

increases expression

Hypochlorous Acid results in increased expression of PAK1IP1 mRNA

NCBI chr 6:10,690,865...10,709,782
Ensembl chr 6:10,694,972...10,709,782

G

poly(A) polymerase alpha

increases expression

Hypochlorous Acid results in increased expression of PAPOLA mRNA

NCBI chr14:96,502,376...96,567,116
Ensembl chr14:96,501,433...96,567,116

G

parvin beta

decreases expression

Hypochlorous Acid results in decreased expression of PARVB mRNA

NCBI chr22:43,999,211...44,172,939
Ensembl chr22:43,999,211...44,172,939

G

protocadherin gamma subfamily C, 3

increases expression

Hypochlorous Acid results in increased expression of PCDHGC3 mRNA

NCBI chr 5:141,475,966...141,512,975
Ensembl chr 5:141,475,947...141,512,977

G

polycomb group ring finger 2

decreases expression

Hypochlorous Acid results in decreased expression of PCGF2 mRNA

NCBI chr17:38,733,898...38,749,792
Ensembl chr17:38,733,898...38,749,817

G

peroxisomal biogenesis factor 6

decreases expression

Hypochlorous Acid results in decreased expression of PEX6 mRNA

NCBI chr 6:42,963,865...42,979,181
Ensembl chr 6:42,963,865...42,979,181

G

progesterone receptor membrane component 2

decreases expression

Hypochlorous Acid results in decreased expression of PGRMC2 mRNA

NCBI chr 4:128,269,242...128,287,813
Ensembl chr 4:128,269,237...128,288,829

G

phosphorylase kinase regulatory subunit alpha 2

decreases expression

Hypochlorous Acid results in decreased expression of PHKA2 mRNA

NCBI chr X:18,892,298...18,984,114
Ensembl chr X:18,892,298...18,984,114

G

phosphorylase kinase catalytic subunit gamma 2

decreases expression

Hypochlorous Acid results in decreased expression of PHKG2 mRNA

NCBI chr16:30,748,425...30,761,176
Ensembl chr16:30,748,293...30,761,176

G

phosphohistidine phosphatase 1

decreases expression

Hypochlorous Acid results in decreased expression of PHPT1 mRNA

NCBI chr 9:136,849,409...136,851,024
Ensembl chr 9:136,848,724...136,851,027

G

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha

increases expression

Hypochlorous Acid results in increased expression of PIK3C2A mRNA

NCBI chr11:17,086,575...17,207,986
Ensembl chr11:17,077,730...17,207,986

G

protein kinase, membrane associated tyrosine/threonine 1

decreases expression

Hypochlorous Acid results in decreased expression of PKMYT1 mRNA

NCBI chr16:2,972,808...2,980,446
Ensembl chr16:2,968,024...2,980,479

G

phospholipase C beta 3

decreases expression

Hypochlorous Acid results in decreased expression of PLCB3 mRNA

NCBI chr11:64,251,530...64,269,452
Ensembl chr11:64,251,530...64,269,150

G

plexin B2

decreases expression

Hypochlorous Acid results in decreased expression of PLXNB2 mRNA

NCBI chr22:50,274,979...50,307,646
Ensembl chr22:50,274,979...50,307,646

G

PNKD metallo-beta-lactamase domain containing

decreases expression

Hypochlorous Acid results in decreased expression of PNKD mRNA

NCBI chr 2:218,270,519...218,346,793
Ensembl chr 2:218,269,651...218,346,793

G

DNA polymerase delta 1, catalytic subunit

decreases expression

Hypochlorous Acid results in decreased expression of POLD1 mRNA

NCBI chr19:50,384,323...50,418,018
Ensembl chr19:50,384,204...50,418,018

G

DNA polymerase lambda

decreases expression

Hypochlorous Acid results in decreased expression of POLL mRNA

NCBI chr10:101,578,882...101,588,270
Ensembl chr10:101,578,882...101,588,270

G

paraoxonase 1

decreases activity
increases oxidation
multiple interactions

Hypochlorous Acid results in decreased activity of PON1 protein
Hypochlorous Acid results in increased oxidation of PON1 protein
Hypochlorous Acid promotes the reaction [Copper promotes the reaction [Ascorbic Acid results in decreased activity of PON1 protein]]

PMID:14671042 PMID:15104111

NCBI chr 7:95,297,676...95,324,532
Ensembl chr 7:95,297,676...95,324,532

G

PTPRF interacting protein alpha 4

decreases expression

Hypochlorous Acid results in decreased expression of PPFIA4 mRNA

NCBI chr 1:203,026,491...203,078,736
Ensembl chr 1:203,026,491...203,078,740

G

protoporphyrinogen oxidase

decreases expression

Hypochlorous Acid results in decreased expression of PPOX mRNA

NCBI chr 1:161,165,728...161,178,013
Ensembl chr 1:161,166,056...161,178,013

G

protein phosphatase 2 scaffold subunit Aalpha

decreases expression

Hypochlorous Acid results in decreased expression of PPP2R1A mRNA

NCBI chr19:52,190,052...52,229,518
Ensembl chr19:52,170,936...52,229,518

G

peroxiredoxin 1

increases expression

Hypochlorous Acid results in increased expression of PRDX1 mRNA

NCBI chr 1:45,511,051...45,522,890
Ensembl chr 1:45,510,914...45,542,732

G

peroxiredoxin 5

multiple interactions
decreases activity

Curcumin inhibits the reaction [Hypochlorous Acid results in decreased activity of PRDX5 protein]

NCBI chr11:64,318,121...64,321,811
Ensembl chr11:64,318,121...64,321,811

G

protein kinase cAMP-dependent type II regulatory subunit beta

increases expression

Hypochlorous Acid results in increased expression of PRKAR2B mRNA

NCBI chr 7:107,044,705...107,161,811
Ensembl chr 7:107,044,705...107,161,811

G

protein C receptor

increases expression

Hypochlorous Acid results in increased expression of PROCR mRNA

NCBI chr20:35,171,096...35,216,259
Ensembl chr20:35,172,072...35,216,240

G

proteasome 20S subunit alpha 7

increases expression

Hypochlorous Acid results in increased expression of PSMA7 mRNA

NCBI chr20:62,136,733...62,143,394
Ensembl chr20:62,136,733...62,143,440

G

proteasome 20S subunit beta 3

increases expression

Hypochlorous Acid results in increased expression of PSMB3 mRNA

NCBI chr17:38,752,741...38,764,225
Ensembl chr17:38,752,741...38,764,225

G

proteasome 26S subunit, ATPase 1

increases expression

Hypochlorous Acid results in increased expression of PSMC1 mRNA

NCBI chr14:90,256,553...90,275,429
Ensembl chr14:90,256,527...90,275,429

G

proteasome 26S subunit, ATPase 2

increases expression

Hypochlorous Acid results in increased expression of PSMC2 mRNA

NCBI chr 7:103,347,524...103,369,395
Ensembl chr 7:103,328,570...103,370,346

G

proteasome 26S subunit, non-ATPase 1

increases expression

Hypochlorous Acid results in increased expression of PSMD1 mRNA

NCBI chr 2:231,056,867...231,172,827
Ensembl chr 2:231,056,845...231,173,116

G

proteasome 26S subunit, non-ATPase 11

increases expression

Hypochlorous Acid results in increased expression of PSMD11 mRNA

NCBI chr17:32,444,510...32,483,319
Ensembl chr17:32,444,379...32,483,319

G

proteasome 26S subunit, non-ATPase 5

increases expression

Hypochlorous Acid results in increased expression of PSMD5 mRNA

NCBI chr 9:120,816,053...120,842,922
Ensembl chr 9:120,815,496...120,842,951

G

proteasome 26S subunit, non-ATPase 7

increases expression

Hypochlorous Acid results in increased expression of PSMD7 mRNA

NCBI chr16:74,296,814...74,306,288
Ensembl chr16:74,296,814...74,306,288

G

polypyrimidine tract binding protein 3

increases expression

Hypochlorous Acid results in increased expression of PTBP3 mRNA

NCBI chr 9:112,217,715...112,379,882
Ensembl chr 9:112,217,716...112,333,664

G

prostaglandin E synthase 2

decreases expression

Hypochlorous Acid results in decreased expression of PTGES2 mRNA

NCBI chr 9:128,120,693...128,128,440
Ensembl chr 9:128,120,693...128,128,462

G

prostaglandin E synthase 3

increases expression

Hypochlorous Acid results in increased expression of PTGES3 mRNA

NCBI chr12:56,663,349...56,688,284
Ensembl chr12:56,663,341...56,688,408

G

prostaglandin I2 receptor

increases expression

Hypochlorous Acid results in increased expression of PTGIR mRNA

NCBI chr19:46,610,687...46,625,089
Ensembl chr19:46,620,468...46,625,089

G

PTOV1 extended AT-hook containing adaptor protein

decreases expression

Hypochlorous Acid results in decreased expression of PTOV1 mRNA

NCBI chr19:49,850,705...49,860,742
Ensembl chr19:49,850,735...49,860,744

G

protein tyrosine phosphatase 4A3

decreases expression

Hypochlorous Acid results in decreased expression of PTP4A3 mRNA

NCBI chr 8:141,392,021...141,432,454
Ensembl chr 8:141,391,995...141,432,454

G

protein tyrosine phosphatase non-receptor type 12

increases expression

Hypochlorous Acid results in increased expression of PTPN12 mRNA

NCBI chr 7:77,537,295...77,640,069
Ensembl chr 7:77,537,295...77,640,069

G

protein tyrosine phosphatase non-receptor type 14

increases expression

Hypochlorous Acid results in increased expression of PTPN14 mRNA

NCBI chr 1:214,348,700...214,551,602
Ensembl chr 1:214,348,700...214,552,449

G

PWWP domain containing 2B

decreases expression

Hypochlorous Acid results in decreased expression of PWWP2B mRNA

NCBI chr10:132,397,200...132,417,859
Ensembl chr10:132,397,168...132,417,859

G

RAB10, member RAS oncogene family

increases expression

Hypochlorous Acid results in increased expression of RAB10 mRNA

NCBI chr 2:26,033,285...26,137,454
Ensembl chr 2:26,034,084...26,137,454

G

RAB18, member RAS oncogene family

increases expression

Hypochlorous Acid results in increased expression of RAB18 mRNA

NCBI chr10:27,504,304...27,542,239
Ensembl chr10:27,504,174...27,543,207

G

RAB22A, member RAS oncogene family

decreases expression

Hypochlorous Acid results in decreased expression of RAB22A mRNA

NCBI chr20:58,309,715...58,367,507
Ensembl chr20:58,309,715...58,367,507

G

rabaptin, RAB GTPase binding effector protein 1

increases expression

Hypochlorous Acid results in increased expression of RABEP1 mRNA

NCBI chr17:5,282,284...5,386,340
Ensembl chr17:5,282,265...5,386,340

G

Ras association domain family member 4

decreases expression

Hypochlorous Acid results in decreased expression of RASSF4 mRNA

NCBI chr10:44,959,802...44,995,891
Ensembl chr10:44,959,407...44,995,891

G

RANBP2-type and C3HC4-type zinc finger containing 1

decreases expression

Hypochlorous Acid results in decreased expression of RBCK1 mRNA

NCBI chr20:408,299...432,139
Ensembl chr20:407,498...432,139

G

RNA binding motif protein 18

increases expression

Hypochlorous Acid results in increased expression of RBM18 mRNA

NCBI chr 9:122,237,622...122,264,840
Ensembl chr 9:122,237,622...122,264,840

G

ring-box 1

increases expression

Hypochlorous Acid results in increased expression of RBX1 mRNA

NCBI chr22:40,951,378...40,973,309
Ensembl chr22:40,951,347...40,973,309

G

radixin

increases expression

Hypochlorous Acid results in increased expression of RDX mRNA

NCBI chr11:110,174,922...110,296,614
Ensembl chr11:109,864,295...110,296,712

G

receptor accessory protein 6

decreases expression

Hypochlorous Acid results in decreased expression of REEP6 mRNA

NCBI chr19:1,491,181...1,497,927
Ensembl chr19:1,491,166...1,497,927

G

ral guanine nucleotide dissociation stimulator like 1

decreases expression

Hypochlorous Acid results in decreased expression of RGL1 mRNA

NCBI chr 1:183,636,109...183,928,532
Ensembl chr 1:183,636,085...183,928,532

G

ral guanine nucleotide dissociation stimulator like 2

decreases expression

Hypochlorous Acid results in decreased expression of RGL2 mRNA

NCBI chr 6:33,291,654...33,301,612
Ensembl chr 6:33,291,654...33,298,942

G

RIC8 guanine nucleotide exchange factor A

increases expression

Hypochlorous Acid results in increased expression of RIC8A mRNA

NCBI chr11:207,708...215,113
Ensembl chr11:207,708...215,113

G

RIO kinase 3

increases expression

Hypochlorous Acid results in increased expression of RIOK3 mRNA

NCBI chr18:23,453,287...23,483,140
Ensembl chr18:23,453,287...23,486,603

G

ribonuclease H1

increases expression

Hypochlorous Acid results in increased expression of RNASEH1 mRNA

NCBI chr 2:3,531,813...3,558,333
Ensembl chr 2:3,541,430...3,558,333

G

ring finger protein 115

increases expression

Hypochlorous Acid results in increased expression of RNF115 mRNA

NCBI chr 1:145,738,868...145,824,095
Ensembl chr 1:145,738,868...145,824,095

G

ring finger protein 128

increases expression

Hypochlorous Acid results in increased expression of RNF128 mRNA

NCBI chr X:106,693,838...106,797,016
Ensembl chr X:106,693,794...106,797,016

G

ring finger protein 157

decreases expression

Hypochlorous Acid results in decreased expression of RNF157 mRNA

NCBI chr17:76,142,474...76,240,493
Ensembl chr17:76,142,465...76,240,493

G

ring finger protein 183

increases expression

Hypochlorous Acid results in increased expression of RNF183 mRNA

NCBI chr 9:113,297,093...113,303,376
Ensembl chr 9:113,297,093...113,303,376

G

ring finger protein 26

decreases expression

Hypochlorous Acid results in decreased expression of RNF26 mRNA

NCBI chr11:119,334,527...119,337,309
Ensembl chr11:119,334,527...119,337,309

G

ring finger protein 4

increases expression

Hypochlorous Acid results in increased expression of RNF4 mRNA

NCBI chr 4:2,469,106...2,515,857
Ensembl chr 4:2,462,220...2,515,857

G

Rho associated coiled-coil containing protein kinase 1

increases expression

Hypochlorous Acid results in increased expression of ROCK1 mRNA

NCBI chr18:20,946,906...21,111,813
Ensembl chr18:20,944,612...21,111,813

G

ribosome production factor 1 homolog

increases expression

Hypochlorous Acid results in increased expression of BXDC5 mRNA

NCBI chr 1:84,479,266...84,498,352
Ensembl chr 1:84,479,259...84,498,352

G

ribosomal protein L35

decreases expression

Hypochlorous Acid results in decreased expression of RPL35 mRNA

NCBI chr 9:124,857,883...124,861,957
Ensembl chr 9:124,857,880...124,861,981

G

ribosomal protein S6 kinase B2

decreases expression

Hypochlorous Acid results in decreased expression of RPS6KB2 mRNA

NCBI chr11:67,428,494...67,435,401
Ensembl chr11:67,428,460...67,435,401

G

ribosomal L1 domain containing 1

increases expression

Hypochlorous Acid results in increased expression of RSL1D1 mRNA

NCBI chr16:11,833,850...11,851,542
Ensembl chr16:11,833,850...11,851,580

G

RuvB like AAA ATPase 2

decreases expression

Hypochlorous Acid results in decreased expression of RUVBL2 mRNA

NCBI chr19:48,993,448...49,015,995
Ensembl chr19:48,993,562...49,015,970

G

RWD domain containing 2A

decreases expression

Hypochlorous Acid results in decreased expression of RWDD2A mRNA

NCBI chr 6:83,193,357...83,198,935
Ensembl chr 6:83,193,357...83,198,935

G

SATB homeobox 2

increases expression

Hypochlorous Acid results in increased expression of SATB2 mRNA

NCBI chr 2:199,269,500...199,471,266
Ensembl chr 2:199,269,505...199,471,266

G

SET binding factor 1

decreases expression

Hypochlorous Acid results in decreased expression of SBF1 mRNA

NCBI chr22:50,445,000...50,475,035
Ensembl chr22:50,443,219...50,483,923

G

SCAN domain containing 1

decreases expression

Hypochlorous Acid results in decreased expression of SCAND1 mRNA

NCBI chr20:35,953,624...35,959,472
Ensembl chr20:35,953,617...35,959,472

G

syndecan 3

decreases expression

Hypochlorous Acid results in decreased expression of SDC3 mRNA

NCBI chr 1:30,869,466...30,909,735
Ensembl chr 1:30,869,466...30,908,758

G

SEC63 homolog, protein translocation regulator

increases expression

Hypochlorous Acid results in increased expression of SEC63 mRNA

NCBI chr 6:107,867,756...107,958,208
Ensembl chr 6:107,867,756...107,958,208

G

selectin P ligand

decreases expression

Hypochlorous Acid results in decreased expression of SELPLG mRNA

NCBI chr12:108,621,895...108,633,894
Ensembl chr12:108,621,895...108,633,894

G

semaphorin 5A

decreases expression

Hypochlorous Acid results in decreased expression of SEMA5A mRNA

NCBI chr 5:9,035,033...9,546,075
Ensembl chr 5:9,035,033...9,546,075

G

secretion regulating guanine nucleotide exchange factor

decreases expression

Hypochlorous Acid results in decreased expression of SERGEF mRNA

NCBI chr11:17,788,048...18,013,047
Ensembl chr11:17,788,048...18,013,047

G

serine incorporator 1

increases expression

Hypochlorous Acid results in increased expression of SERINC1 mRNA

NCBI chr 6:122,443,351...122,471,807
Ensembl chr 6:122,443,351...122,471,807

G

serpin family B member 9

increases expression

Hypochlorous Acid results in increased expression of SERPINB9 mRNA

NCBI chr 6:2,887,270...2,903,309
Ensembl chr 6:2,887,270...2,903,309

G

serpin family E member 1

increases expression

Hypochlorous Acid results in increased expression of SERPINE1 mRNA

NCBI chr 7:101,127,104...101,139,247
Ensembl chr 7:101,127,104...101,139,247

G

SET domain containing 6, protein lysine methyltransferase

decreases expression

Hypochlorous Acid results in decreased expression of SETD6 mRNA

NCBI chr16:58,515,479...58,523,842
Ensembl chr16:58,515,479...58,523,842

G

SH2B adaptor protein 2

decreases expression

Hypochlorous Acid results in decreased expression of SH2B2 mRNA

NCBI chr 7:102,285,141...102,321,711
Ensembl chr 7:102,285,091...102,321,711

G

SH3 domain binding protein 1

decreases expression

Hypochlorous Acid results in decreased expression of SH3BP1 mRNA

NCBI chr22:37,639,669...37,656,117
Ensembl chr22:37,634,654...37,656,117

G

single Ig and TIR domain containing

decreases expression

Hypochlorous Acid results in decreased expression of SIGIRR mRNA

NCBI chr11:405,716...417,397
Ensembl chr11:405,716...417,455

G

signal induced proliferation associated 1 like 1

decreases expression

Hypochlorous Acid results in decreased expression of SIPA1L1 mRNA

NCBI chr14:71,320,476...71,741,209
Ensembl chr14:71,320,449...71,741,229

G

Src like adaptor

decreases expression

Hypochlorous Acid results in decreased expression of SLA mRNA

NCBI chr 8:133,036,728...133,102,602
Ensembl chr 8:133,036,728...133,102,912

G

solute carrier family 20 member 1

decreases expression

Hypochlorous Acid results in decreased expression of SLC20A1 mRNA

NCBI chr 2:112,645,939...112,663,825
Ensembl chr 2:112,645,939...112,663,825

G

solute carrier family 23 member 2

increases expression

Hypochlorous Acid results in increased expression of SLC23A2 mRNA

NCBI chr20:4,852,358...5,010,313
Ensembl chr20:4,852,356...5,010,293

G

solute carrier family 25 member 1

decreases expression

Hypochlorous Acid results in decreased expression of SLC25A1 mRNA

NCBI chr22:19,175,581...19,178,736
Ensembl chr22:19,175,581...19,178,739

G

solute carrier family 25 member 12

increases expression

Hypochlorous Acid results in increased expression of SLC25A12 mRNA

NCBI chr 2:171,783,405...171,894,244
Ensembl chr 2:171,783,405...171,999,859

G

solute carrier family 25 member 28

decreases expression

Hypochlorous Acid results in decreased expression of SLC25A28 mRNA

NCBI chr10:99,610,522...99,659,286
Ensembl chr10:99,610,519...99,622,793

G

solute carrier family 25 member 39

decreases expression

Hypochlorous Acid results in decreased expression of SLC25A39 mRNA

NCBI chr17:44,319,628...44,324,823
Ensembl chr17:44,319,625...44,324,870

G

solute carrier family 35 member B2

decreases expression

Hypochlorous Acid results in decreased expression of SLC35B2 mRNA

NCBI chr 6:44,254,101...44,257,890
Ensembl chr 6:44,254,096...44,257,890

G

solute carrier family 35 member C2

decreases expression

Hypochlorous Acid results in decreased expression of SLC35C2 mRNA

NCBI chr20:46,345,984...46,364,425
Ensembl chr20:46,345,980...46,364,458

G

solute carrier family 39 member 6

increases expression

Hypochlorous Acid results in increased expression of SLC39A6 mRNA

NCBI chr18:36,108,531...36,129,340
Ensembl chr18:36,108,531...36,129,385

G

solute carrier family 40 member 1

increases expression

Hypochlorous Acid results in increased expression of SLC40A1 mRNA

NCBI chr 2:189,560,590...189,580,786
Ensembl chr 2:189,560,590...189,583,758

G

solute carrier family 50 member 1

decreases expression

Hypochlorous Acid results in decreased expression of RAG1AP1 mRNA

NCBI chr 1:155,135,375...155,138,853
Ensembl chr 1:155,135,344...155,138,857

G

solute carrier family 7 member 11

increases expression

Hypochlorous Acid results in increased expression of SLC7A11 mRNA

NCBI chr 4:138,164,097...138,312,671
Ensembl chr 4:138,164,097...138,242,349

G

STE20 like kinase

increases expression

Hypochlorous Acid results in increased expression of SLK mRNA

NCBI chr10:103,967,140...104,029,233
Ensembl chr10:103,967,140...104,029,233

G

sarcolemma associated protein

increases expression

Hypochlorous Acid results in increased expression of SLMAP mRNA

NCBI chr 3:57,756,309...57,930,013
Ensembl chr 3:57,755,450...57,930,003

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5

increases expression

Hypochlorous Acid results in increased expression of SMARCA5 mRNA

NCBI chr 4:143,513,702...143,557,486
Ensembl chr 4:143,513,702...143,557,486

G

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2

decreases expression

Hypochlorous Acid results in decreased expression of SMARCD2 mRNA

NCBI chr17:63,832,081...63,842,685
Ensembl chr17:63,832,081...63,843,065

G

SET and MYND domain containing 1

decreases expression

Hypochlorous Acid results in decreased expression of SMYD1 mRNA

NCBI chr 2:88,067,825...88,113,384
Ensembl chr 2:88,067,825...88,113,384

G

SET and MYND domain containing 4

increases expression

Hypochlorous Acid results in increased expression of SMYD4 mRNA

NCBI chr17:1,779,485...1,829,902
Ensembl chr17:1,779,485...1,830,634

G

small nuclear ribonucleoprotein polypeptide A

decreases expression

Hypochlorous Acid results in decreased expression of SNRPA mRNA

NCBI chr19:40,751,203...40,765,389
Ensembl chr19:40,750,637...40,765,389

G

sorting nexin 17

decreases expression

Hypochlorous Acid results in decreased expression of SNX17 mRNA

NCBI chr 2:27,370,616...27,377,535
Ensembl chr 2:27,370,496...27,377,535

G

sorting nexin 6

increases expression

Hypochlorous Acid results in increased expression of SNX6 mRNA

NCBI chr14:34,561,093...34,630,148
Ensembl chr14:34,561,093...34,630,160

G

superoxide dismutase 1

increases expression
multiple interactions
increases activity

Hypochlorous Acid results in increased expression of SOD1 protein
Curcumin inhibits the reaction [Hypochlorous Acid results in increased activity of SOD1 protein]

PMID:19376150 PMID:36924976

NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,666...31,668,931

G

sequestosome 1

increases expression

Hypochlorous Acid results in increased expression of SQSTM1 mRNA

NCBI chr 5:179,806,393...179,838,078
Ensembl chr 5:179,806,398...179,838,078

G

sulfiredoxin 1

increases expression

Hypochlorous Acid results in increased expression of SRXN1 mRNA

NCBI chr20:646,615...653,200
Ensembl chr20:646,615...653,200

G

small RNA binding exonuclease protection factor La

increases expression

Hypochlorous Acid results in increased expression of SSB mRNA

NCBI chr 2:169,798,871...169,812,064
Ensembl chr 2:169,791,933...169,812,064

G

ST14 transmembrane serine protease matriptase

decreases expression

Hypochlorous Acid results in decreased expression of ST14 mRNA

NCBI chr11:130,159,782...130,210,362
Ensembl chr11:130,159,782...130,210,362

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 3

decreases expression

Hypochlorous Acid results in decreased expression of ST3GAL3 mRNA

NCBI chr 1:43,707,536...43,931,159
Ensembl chr 1:43,705,824...43,931,165

G

STIM activating enhancer

decreases expression

Hypochlorous Acid results in decreased expression of STIMATE mRNA

NCBI chr 3:52,836,733...52,897,548
Ensembl chr 3:52,836,219...52,897,548

G

syntaxin binding protein 2

decreases expression

Hypochlorous Acid results in decreased expression of STXBP2 mRNA

NCBI chr19:7,629,793...7,647,873
Ensembl chr19:7,636,772...7,647,873

G

TAO kinase 1

increases expression

Hypochlorous Acid results in increased expression of TAOK1 mRNA

NCBI chr17:29,390,363...29,551,903
Ensembl chr17:29,390,363...29,551,903

G

TBC1 domain family member 23

increases expression

Hypochlorous Acid results in increased expression of TBC1D23 mRNA

NCBI chr 3:100,260,992...100,325,238
Ensembl chr 3:100,260,992...100,325,251

G

tubulin folding cofactor D

decreases expression

Hypochlorous Acid results in decreased expression of TBCD mRNA

NCBI chr17:82,752,065...82,945,914
Ensembl chr17:82,752,042...82,945,914

G

tubulin folding cofactor E like

increases expression

Hypochlorous Acid results in increased expression of TBCEL mRNA

NCBI chr11:121,024,102...121,090,776
Ensembl chr11:121,024,072...121,090,776

G

transforming growth factor beta regulator 4

decreases expression

Hypochlorous Acid results in decreased expression of TBRG4 mRNA

NCBI chr 7:45,100,100...45,111,697
Ensembl chr 7:45,100,100...45,112,047

G

transferrin receptor

increases expression

Hypochlorous Acid results in increased expression of TFRC mRNA

NCBI chr 3:196,049,284...196,082,090
Ensembl chr 3:196,012,511...196,082,153

G

TRAF interacting protein with forkhead associated domain

decreases expression

Hypochlorous Acid results in decreased expression of TIFA mRNA

NCBI chr 4:112,274,537...112,285,904
Ensembl chr 4:112,272,968...112,285,955

G

translocase of inner mitochondrial membrane 44

decreases expression

Hypochlorous Acid results in decreased expression of TIMM44 mRNA

NCBI chr19:7,926,718...7,943,666
Ensembl chr19:7,926,718...7,943,667

G

tight junction protein 3

decreases expression

Hypochlorous Acid results in decreased expression of TJP3 mRNA

NCBI chr19:3,708,384...3,750,813
Ensembl chr19:3,708,362...3,750,813

G

transmembrane p24 trafficking protein 2

increases expression

Hypochlorous Acid results in increased expression of TMED2 mRNA

NCBI chr12:123,584,552...123,598,582
Ensembl chr12:123,584,533...123,598,582

G

transmembrane protein 128

increases expression

Hypochlorous Acid results in increased expression of TMEM128 mRNA

NCBI chr 4:4,235,542...4,248,223
Ensembl chr 4:4,235,542...4,248,223

G

transmembrane protein 33

increases expression

Hypochlorous Acid results in increased expression of TMEM33 mRNA

NCBI chr 4:41,935,137...41,960,803
Ensembl chr 4:41,935,129...41,960,803

G

trinucleotide repeat containing adaptor 6A

increases expression

Hypochlorous Acid results in increased expression of TNRC6A mRNA

NCBI chr16:24,610,205...24,826,218
Ensembl chr16:24,610,209...24,827,632

G

DNA topoisomerase II binding protein 1

decreases expression

Hypochlorous Acid results in decreased expression of TOPBP1 mRNA

NCBI chr 3:133,600,238...133,661,941
Ensembl chr 3:133,598,175...133,662,380

G

tumor protein p53 inducible protein 11

decreases expression

Hypochlorous Acid results in decreased expression of TRP53I11 mRNA

NCBI chr11:44,932,348...44,951,306
Ensembl chr11:44,885,903...44,951,306

G

tripeptidyl peptidase 2

increases expression

Hypochlorous Acid results in increased expression of TPP2 mRNA

NCBI chr13:102,596,986...102,679,958
Ensembl chr13:102,596,958...102,679,958

G

TNF receptor associated protein 1

decreases expression

Hypochlorous Acid results in decreased expression of TRAP1 mRNA

NCBI chr16:3,658,037...3,717,524
Ensembl chr16:3,651,639...3,717,553

G

triggering receptor expressed on myeloid cells like 4

increases expression

Hypochlorous Acid results in increased expression of TREML4 mRNA

NCBI chr 6:41,228,349...41,238,882
Ensembl chr 6:41,228,339...41,238,882

G

tripartite motif containing 27

decreases expression

Hypochlorous Acid results in decreased expression of TRIM27 mRNA

NCBI chr 6:28,903,002...28,923,985
Ensembl chr 6:28,903,002...28,923,988

G

tRNA phosphotransferase 1

decreases expression

Hypochlorous Acid results in decreased expression of TRPT1 mRNA

NCBI chr11:64,223,799...64,226,257
Ensembl chr11:64,223,799...64,226,254

G

tetratricopeptide repeat domain 1

increases expression

Hypochlorous Acid results in increased expression of TTC1 mRNA

NCBI chr 5:160,009,139...160,065,543
Ensembl chr 5:160,009,113...160,065,543

G

tubulin tyrosine ligase like 3

decreases expression

Hypochlorous Acid results in decreased expression of TTLL3 mRNA

NCBI chr 3:9,809,727...9,836,365
Ensembl chr 3:9,808,086...9,855,138

G

thioredoxin domain containing 9

increases expression

Hypochlorous Acid results in increased expression of TXNDC9 mRNA

NCBI chr 2:99,306,184...99,336,333
Ensembl chr 2:99,318,982...99,340,702

G

thioredoxin reductase 1

increases expression

Hypochlorous Acid results in increased expression of TXNRD1 mRNA

PMID:18156441 PMID:19376150

NCBI chr12:104,215,779...104,350,307
Ensembl chr12:104,215,779...104,350,307

G

ubiquitin conjugating enzyme E2 D3

increases expression

Hypochlorous Acid results in increased expression of UBE2D3 mRNA

NCBI chr 4:102,794,383...102,868,895
Ensembl chr 4:102,794,383...102,868,896

G

UDP-glucose ceramide glucosyltransferase

increases expression

Hypochlorous Acid results in increased expression of UGCG mRNA

NCBI chr 9:111,896,814...111,935,369
Ensembl chr 9:111,896,814...111,935,369

G

unc-119 lipid binding chaperone

decreases expression

Hypochlorous Acid results in decreased expression of UNC119 mRNA

NCBI chr17:28,546,707...28,552,628
Ensembl chr17:28,546,708...28,552,631

G

unc-93 homolog B1, TLR signaling regulator

decreases expression

Hypochlorous Acid results in decreased expression of UNC93B1 mRNA

NCBI chr11:67,991,100...68,004,097
Ensembl chr11:67,991,100...68,004,982

G

USO1 vesicle transport factor

increases expression

Hypochlorous Acid results in increased expression of USO1 mRNA

NCBI chr 4:75,724,577...75,814,286
Ensembl chr 4:75,724,577...75,814,286

G

ubiquitin specific peptidase 12

increases expression

Hypochlorous Acid results in increased expression of USP12 mRNA

NCBI chr13:27,066,156...27,171,811
Ensembl chr13:27,066,156...27,171,811

G

ubiquitin specific peptidase 15

increases expression

Hypochlorous Acid results in increased expression of USP15 mRNA

NCBI chr12:62,260,404...62,416,389
Ensembl chr12:62,260,338...62,417,431

G

ubiquitin specific peptidase 16

increases expression

Hypochlorous Acid results in increased expression of USP16 mRNA

NCBI chr21:29,024,668...29,054,488
Ensembl chr21:29,024,629...29,054,488

G

ubiquitin specific peptidase 2

decreases expression

Hypochlorous Acid results in decreased expression of USP2 mRNA

NCBI chr11:119,355,215...119,381,690
Ensembl chr11:119,355,215...119,381,711

G

vesicle associated membrane protein 2

decreases expression

Hypochlorous Acid results in decreased expression of VAMP2 mRNA

NCBI chr17:8,159,147...8,162,948
Ensembl chr17:8,159,149...8,163,546

G

valyl-tRNA synthetase 2, mitochondrial

decreases expression

Hypochlorous Acid results in decreased expression of VARS2 mRNA

NCBI chr 6:30,914,238...30,926,459
Ensembl chr 6:30,914,205...30,926,459

G

vacuole membrane protein 1

increases expression

Hypochlorous Acid results in increased expression of VMP1 mRNA

NCBI chr17:59,707,654...59,842,255
Ensembl chr17:59,707,192...59,842,255

G

vacuolar protein sorting 13 homolog D

decreases expression

Hypochlorous Acid results in decreased expression of VPS13D mRNA

NCBI chr 1:12,230,030...12,512,047
Ensembl chr 1:12,230,030...12,512,047

G

VPS16 core subunit of CORVET and HOPS complexes

decreases expression

Hypochlorous Acid results in decreased expression of VPS16 mRNA

NCBI chr20:2,840,745...2,866,732
Ensembl chr20:2,840,703...2,866,732

G

VPS35 retromer complex component

increases expression

Hypochlorous Acid results in increased expression of VPS35 mRNA

NCBI chr16:46,656,132...46,689,178
Ensembl chr16:46,656,132...46,689,518

G

VPS54 subunit of GARP complex

increases expression

Hypochlorous Acid results in increased expression of VPS54 mRNA

NCBI chr 2:63,892,150...64,019,428
Ensembl chr 2:63,892,146...64,019,428

G

WW domain binding protein 1

decreases expression

Hypochlorous Acid results in decreased expression of WBP1 mRNA

NCBI chr 2:74,458,438...74,460,881
Ensembl chr 2:74,458,400...74,460,891

G

WD repeat domain 62

decreases expression

Hypochlorous Acid results in decreased expression of WDR62 mRNA

NCBI chr19:36,054,897...36,111,145
Ensembl chr19:36,054,649...36,105,108

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta

increases expression

Hypochlorous Acid results in increased expression of YWHAZ mRNA

NCBI chr 8:100,916,523...100,953,382
Ensembl chr 8:100,916,523...100,953,388

G

zinc finger and BTB domain containing 47

decreases expression

Hypochlorous Acid results in decreased expression of ZBTB47 mRNA

NCBI chr 3:42,652,931...42,667,580
Ensembl chr 3:42,653,697...42,667,580

G

zinc finger CCCH-type containing 15

increases expression

Hypochlorous Acid results in increased expression of ZC3H15 mRNA

NCBI chr 2:186,486,260...186,509,361
Ensembl chr 2:186,486,253...186,509,361

G

zinc finger DHHC-type palmitoyltransferase 14

decreases expression

Hypochlorous Acid results in decreased expression of ZDHHC14 mRNA

NCBI chr 6:157,381,190...157,678,157
Ensembl chr 6:157,381,133...157,678,157

G

zinc finger protein, FOG family member 1

decreases expression

Hypochlorous Acid results in decreased expression of ZFPM1 mRNA

NCBI chr16:88,451,769...88,537,031
Ensembl chr16:88,453,280...88,537,031

G

zinc finger MYM-type containing 3

decreases expression

Hypochlorous Acid results in decreased expression of ZMYM3 mRNA

NCBI chr X:71,239,624...71,255,290
Ensembl chr X:71,239,624...71,255,146

G

zinc finger protein 24

increases expression

Hypochlorous Acid results in increased expression of ZFP24 mRNA

NCBI chr18:35,332,227...35,344,420
Ensembl chr18:35,332,227...35,345,482

G

zinc finger protein 316

decreases expression

Hypochlorous Acid results in decreased expression of ZFP316 mRNA

NCBI chr 7:6,637,318...6,658,279
Ensembl chr 7:6,637,318...6,658,279

G

zinc finger protein 414

decreases expression

Hypochlorous Acid results in decreased expression of ZFP414 mRNA

NCBI chr19:8,509,678...8,514,167
Ensembl chr19:8,509,678...8,514,167

G

zinc finger protein 638

increases expression

Hypochlorous Acid results in increased expression of ZFP638 mRNA

NCBI chr 2:71,331,782...71,435,061
Ensembl chr 2:71,276,561...71,435,069

G

zinc finger protein 652

decreases expression

Hypochlorous Acid results in decreased expression of ZFP652 mRNA

NCBI chr17:49,288,117...49,362,473
Ensembl chr17:49,289,206...49,362,473

G

ZW10 interacting kinetochore protein

increases expression

Hypochlorous Acid results in increased expression of ZWINT mRNA

NCBI chr10:56,357,227...56,361,273
Ensembl chr10:56,357,227...56,361,273

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	26034
role	25961
chemical role	24242
donor	23222
Bronsted acid	23023
inorganic acid	17079
halogen oxoacid	399
bromine oxoacid +	0
chlorine oxoacid +	399
fluorine oxoacid +	0
iodine oxoacid +	0
Path 2
Term	Annotations
CHEBI ontology	26034
subatomic particle	26009
composite particle	26009
hadron	26020
baryon	26009
nucleon	26009
atomic nucleus	26009
atom	26009
main group element atom	25834
p-block element atom	25834
chalcogen	24917
oxygen atom	24817
oxygen molecular entity	24806
hydroxides	24049
oxoacid	22975
halogen oxoacid	399
bromine oxoacid +	0
chlorine oxoacid +	399
fluorine oxoacid +	0
iodine oxoacid +	0

paths to the root