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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hydracid
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Accession:CHEBI:33405 term browser browse the term
Definition:A hydracid is a compound which contains hydrogen that is not bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
Synonyms:related_synonym: hydracids



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1,3-benzothiazole-2-thiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TPO thyroid peroxidase decreases activity EXP captax results in decreased activity of TPO protein CTD PMID:23959146 PMID:25953703 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,408,943
JBrowse link
1,4-dithiothreitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH7A1 aldehyde dehydrogenase 7 family member A1 multiple interactions EXP Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein] CTD PMID:21296058 NCBI chr 2:129,663,226...129,709,728
Ensembl chr 2:129,662,296...129,713,729
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Dithiothreitol metabolite results in increased expression of HSPA5 protein CTD PMID:17416481 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions EXP Dithiothreitol inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Dithiothreitol inhibits the reaction [Cadmium results in decreased activity of IDH2 protein] CTD PMID:16785314 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,606...55,681,426
JBrowse link
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions EXP Verapamil inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines] CTD PMID:21056966 NCBI chr 9:93,171,371...93,262,124 JBrowse link
cysteamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G FMO1 flavin containing dimethylaniline monoxygenase 1 increases metabolic processing EXP FMO1 protein results in increased metabolism of Cysteamine CTD PMID:6439199 NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,812,103...63,895,077
JBrowse link
dimercaprol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin multiple interactions EXP Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]] CTD PMID:1928324 NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841
JBrowse link
glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions EXP Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Glutathione inhibits the reaction [Cadmium results in decreased activity of IDH2 protein] CTD PMID:16785314 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,606...55,681,426
JBrowse link
G LOC100739508 glutathione S-transferase P-like multiple interactions EXP GSTP1 protein affects the metabolism of [monobromobimane co-treated with Glutathione] CTD PMID:14573868 NCBI chr 2:5,005,498...5,009,247 JBrowse link
L-1,4-dithiothreitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH7A1 aldehyde dehydrogenase 7 family member A1 multiple interactions EXP Dithiothreitol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein] CTD PMID:21296058 NCBI chr 2:129,663,226...129,709,728
Ensembl chr 2:129,662,296...129,713,729
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Dithiothreitol metabolite results in increased expression of HSPA5 protein CTD PMID:17416481 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,904
JBrowse link
G IDH2 isocitrate dehydrogenase (NADP(+)) 2 multiple interactions EXP Dithiothreitol inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Dithiothreitol inhibits the reaction [Cadmium results in decreased activity of IDH2 protein] CTD PMID:16785314 NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,606...55,681,426
JBrowse link
melamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH2 cadherin 2 decreases expression EXP melamine results in decreased expression of CDH2 protein CTD PMID:30055240 NCBI chr 6:112,396,713...112,629,073
Ensembl chr 6:112,396,721...112,628,432
JBrowse link
G GJA1 gap junction protein alpha 1 decreases expression EXP melamine results in decreased expression of GJA1 protein CTD PMID:30055240 NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,515...41,002,137
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP melamine results in increased phosphorylation of MAPK1 protein CTD PMID:30055240 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,523
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP melamine results in increased phosphorylation of MAPK3 protein CTD PMID:30055240 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567
JBrowse link
G OCLN occludin decreases expression EXP melamine results in decreased expression of OCLN protein CTD PMID:30055240 NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,498...47,654,033
JBrowse link
G TJP1 tight junction protein 1 decreases expression EXP melamine results in decreased expression of TJP1 protein CTD PMID:30055240 NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,368...145,195,836
JBrowse link
mercaptoethanol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALDH7A1 aldehyde dehydrogenase 7 family member A1 multiple interactions EXP Mercaptoethanol inhibits the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein] CTD PMID:21296058 NCBI chr 2:129,663,226...129,709,728
Ensembl chr 2:129,662,296...129,713,729
JBrowse link
S-nitrosoglutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 multiple interactions EXP AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression
EXP 2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Genistein inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Wortmannin inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,181...190,674,850
JBrowse link
G PIK3R1 phosphoinositide-3-kinase regulatory subunit 1 multiple interactions EXP PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein] CTD PMID:11514583 NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,434,873...46,523,609
JBrowse link
sulforaphane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP sulforaphane inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA] CTD PMID:21130106 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,028
JBrowse link
G FIS1 fission, mitochondrial 1 decreases expression EXP sulforaphane results in decreased expression of FIS1 protein CTD PMID:27993529 NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,931,104...8,941,865
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit increases expression
increases activity
multiple interactions
EXP sulforaphane results in increased expression of GCLC mRNA
sulforaphane results in increased activity of GCLC protein
Buthionine Sulfoximine inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]]; ochratoxin A inhibits the reaction [sulforaphane results in increased expression of GCLC mRNA]; sulforaphane inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]
CTD PMID:18547363 PMID:20732396 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 multiple interactions
increases expression
EXP ochratoxin A inhibits the reaction [sulforaphane results in increased expression of GSTA1 mRNA] CTD PMID:18547363 NCBI chr 7:46,538,743...46,550,781
Ensembl chr 7:46,538,032...46,567,728
JBrowse link
G HMOX1 heme oxygenase 1 multiple interactions
increases expression
EXP NFE2L2 protein affects the reaction [sulforaphane results in increased expression of HMOX1 protein] CTD PMID:28710020
G MT-ND1 mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1 increases expression EXP sulforaphane results in increased expression of ND1 protein CTD PMID:27993529 NCBI chr MT:3,922...4,876
Ensembl chr MT:3,922...4,876
JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions
increases activity
affects localization
increases expression
EXP NFE2L2 protein affects the reaction [sulforaphane results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [sulforaphane results in increased expression of NQO1 protein]; ochratoxin A inhibits the reaction [sulforaphane affects the localization of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforaphane results in increased expression of NFE2L2 mRNA]; sulforaphane results in increased expression of and results in increased activity of NFE2L2 protein CTD PMID:18547363 PMID:19913604 PMID:21130106 PMID:28710020 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
G NQO1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
increases activity
EXP Dicumarol inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein]]; NFE2L2 protein affects the reaction [sulforaphane results in increased expression of NQO1 protein]; sulforaphane inhibits the reaction [Cisplatin results in decreased activity of NQO1 protein]
sulforaphane results in increased activity of NQO1 protein
CTD PMID:20732396 PMID:28710020 NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,769...17,302,590
JBrowse link
G NRF1 nuclear respiratory factor 1 increases expression EXP sulforaphane results in increased expression of NRF1 protein CTD PMID:27993529 NCBI chr18:19,008,408...19,142,678
Ensembl chr18:18,998,905...19,142,628
JBrowse link
G TFAM transcription factor A, mitochondrial increases expression EXP sulforaphane results in increased expression of TFAM protein CTD PMID:27993529 NCBI chr14:92,261,713...92,279,731
Ensembl chr14:92,259,403...92,279,550
JBrowse link
G TGFB1 transforming growth factor beta 1 multiple interactions EXP sulforaphane inhibits the reaction [ochratoxin A results in increased expression of TGFB1 mRNA] CTD PMID:28710020 NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,169...49,349,048
JBrowse link
verapamil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB4 ATP binding cassette subfamily B member 4 multiple interactions EXP Verapamil inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines] CTD PMID:21056966 NCBI chr 9:93,171,371...93,262,124 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 909
    role 868
      chemical role 660
        acid 338
          Bronsted acid 338
            hydracid 28
              (methylidyneammoniumyl)selanide 0
              carbidoselanidonitrogen 0
              carbohydrazonic acid + 0
              fulminic acid 0
              hydrogen cyanide + 7
              hydrogen halide + 0
              hydrogen isocyanide + 0
              hydrogen sulfide + 10
              isocyanic acid + 0
              isoselenocyanic acid + 0
              isotellurocyanic acid + 0
              isothiocyanic acid + 11
              isothiofulminic acid 0
              parabanic acid + 0
              selenocyanic acid + 0
              tellurocyanic acid 0
              thiocyanic acid + 0
              thiofulminic acid 0
              thionitrous acid 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 909
    subatomic particle 894
      composite particle 894
        hadron 894
          baryon 894
            nucleon 894
              atomic nucleus 894
                atom 894
                  main group element atom 863
                    main group molecular entity 861
                      s-block molecular entity 750
                        hydrogen molecular entity 736
                          hydracid 28
                            (methylidyneammoniumyl)selanide 0
                            carbidoselanidonitrogen 0
                            carbohydrazonic acid + 0
                            fulminic acid 0
                            hydrogen cyanide + 7
                            hydrogen halide + 0
                            hydrogen isocyanide + 0
                            hydrogen sulfide + 10
                            isocyanic acid + 0
                            isoselenocyanic acid + 0
                            isotellurocyanic acid + 0
                            isothiocyanic acid + 11
                            isothiofulminic acid 0
                            parabanic acid + 0
                            selenocyanic acid + 0
                            tellurocyanic acid 0
                            thiocyanic acid + 0
                            thiofulminic acid 0
                            thionitrous acid 0
paths to the root