manganese group element atom - Ontology Report

mancozeb affects the activity of ACHE protein
[carbendazim co-treated with mancozeb] results in increased activity of ACHE protein

PMID:10641187 PMID:33217513

NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651

Actg1

actin, gamma 1

increases expression

mancozeb results in increased expression of ACTG1 protein

NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232

Actmap

actin maturation protease

decreases expression

mancozeb results in decreased expression of ACTMAP mRNA

NCBI chr 1:82,490,313...82,499,841
Ensembl chr 1:82,490,363...82,499,841

Akt1

AKT serine/threonine kinase 1

multiple interactions

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

Alb

albumin

decreases expression

mancozeb results in decreased expression of ALB protein

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

Aldh2

aldehyde dehydrogenase 2 family member

decreases activity

mancozeb results in decreased activity of ALDH2 protein

PMID:17010440

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

Aldh5a1

aldehyde dehydrogenase 5 family, member A1

decreases activity

mancozeb results in decreased activity of ALDH5A1 protein

PMID:17010440

NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677

Angptl1

angiopoietin-like 1

decreases expression

mancozeb results in decreased expression of ANGPTL1 mRNA

NCBI chr13:68,963,198...68,969,742
Ensembl chr13:68,962,991...68,992,570

Anxa2

annexin A2

decreases expression

mancozeb results in decreased expression of ANXA2 protein

NCBI chr 8:70,105,268...70,141,663
Ensembl chr 8:70,105,253...70,141,658

Apaf1

apoptotic peptidase activating factor 1

increases expression

mancozeb results in increased expression of APAF1 protein

PMID:22289270

NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540

androgen receptor

multiple interactions
decreases expression
decreases activity

mancozeb inhibits the reaction [Dihydrotestosterone binds to and results in increased activity of AR protein]; mancozeb inhibits the reaction [Metribolone binds to and results in increased activity of AR protein]
mancozeb results in decreased expression of AR mRNA
mancozeb results in decreased activity of AR protein

PMID:23871939 PMID:33396126

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

Atp1a2

ATPase Na+/K+ transporting subunit alpha 2

decreases expression

mancozeb results in decreased expression of ATP1A2 mRNA

NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544

Bax

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

mancozeb results in increased expression of BAX mRNA; mancozeb results in increased expression of BAX protein
lupeol inhibits the reaction [mancozeb results in increased expression of BAX mRNA]

PMID:22289270 PMID:27235710

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

Bcl2

BCL2, apoptosis regulator

decreases expression
multiple interactions

mancozeb results in decreased expression of BCL2 mRNA; mancozeb results in decreased expression of BCL2 protein
lupeol inhibits the reaction [mancozeb results in decreased expression of BCL2 mRNA]
alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of BCL2 protein]

PMID:16005924 PMID:22289270 PMID:27235710

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

Car3

carbonic anhydrase 3

increases expression

mancozeb results in increased expression of CAR3 protein

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

Casp3

caspase 3

increases activity
multiple interactions
increases cleavage

mancozeb results in increased activity of CASP3 protein
Acetylcysteine inhibits the reaction [mancozeb results in increased cleavage of CASP3 protein]
mancozeb results in increased cleavage of and results in increased activity of CASP3 protein

PMID:22289270 PMID:22824503 PMID:30037311

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Casp7

caspase 7

increases activity

mancozeb results in increased activity of CASP7 protein

PMID:22824503

NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729

Casp8

caspase 8

increases activity

mancozeb results in increased activity of CASP8 protein

PMID:22289270 PMID:22824503

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

Casp9

caspase 9

increases activity
multiple interactions

mancozeb results in increased activity of CASP9 protein
mancozeb results in increased cleavage of and results in increased activity of CASP9 protein

PMID:22289270 PMID:22824503

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

Cat

catalase

multiple interactions
decreases activity

Acetylcysteine inhibits the reaction [mancozeb results in decreased activity of CAT protein]; lupeol inhibits the reaction [mancozeb results in decreased activity of CAT protein]; Quercetin inhibits the reaction [mancozeb results in decreased activity of CAT protein]
Colforsin inhibits the reaction [mancozeb results in decreased activity of CAT protein]

PMID:23024109 PMID:27235710 PMID:29283200 PMID:30037311

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

Ccdc106

coiled-coil domain containing 106

decreases expression

mancozeb results in decreased expression of CCDC106 mRNA

NCBI chr 1:68,779,882...68,791,140
Ensembl chr 1:68,779,882...68,786,846

Ccnd1

cyclin D1

multiple interactions
increases expression

[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of CCND1 protein
mancozeb results in increased expression of CCND1 protein

PMID:19883720 PMID:21375462

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

Cdc25c

cell division cycle 25C

increases phosphorylation

mancozeb results in increased phosphorylation of CDC25C protein

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

Cdkn1a

cyclin-dependent kinase inhibitor 1A

multiple interactions
increases expression

lupeol inhibits the reaction [mancozeb results in increased expression of CDKN1A mRNA]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

Cfap126

cilia and flagella associated protein 126

decreases expression

mancozeb results in decreased expression of CFAP126 mRNA

NCBI chr13:83,526,657...83,542,552
Ensembl chr13:83,526,657...83,542,552

Cldn16

claudin 16

decreases expression

mancozeb results in decreased expression of CLDN16 mRNA

NCBI chr11:74,290,298...74,309,588
Ensembl chr11:74,290,298...74,309,588

Ctf1

cardiotrophin 1

decreases expression

mancozeb results in decreased expression of CTF1 mRNA

NCBI chr 1:182,328,035...182,336,346
Ensembl chr 1:182,328,090...182,333,335

Cycs

cytochrome c, somatic

increases expression

mancozeb results in increased expression of CYCS protein

PMID:27016407

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054

Cyp1a1

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity
decreases expression

mancozeb results in decreased activity of CYP1A1 protein
mancozeb results in decreased expression of CYP1A1 protein

PMID:1946188 PMID:31096615

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

Cyp2b3

cytochrome P450, family 2, subfamily b, polypeptide 3

decreases expression

mancozeb results in decreased expression of CYP2B6 protein

PMID:31096615

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

Cyp2e1

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases expression

mancozeb results in decreased expression of CYP2E1 mRNA

PMID:31096615

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

Cyp3a2

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases expression

mancozeb results in decreased expression of CYP3A4 mRNA; mancozeb results in decreased expression of CYP3A4 protein

PMID:31096615

NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008

Ddit4

DNA-damage-inducible transcript 4

increases expression

mancozeb results in increased expression of DDIT4 protein

PMID:24764117

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

Efcab12

EF-hand calcium binding domain 12

decreases expression

mancozeb results in decreased expression of EFCAB12 mRNA

NCBI chr 4:148,869,381...148,892,922
Ensembl chr 4:148,869,387...148,890,560

Elk1

ETS transcription factor ELK1

increases phosphorylation

mancozeb results in increased phosphorylation of ELK1 protein

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

Esr1

estrogen receptor 1

decreases expression

mancozeb results in decreased expression of ESR1 mRNA

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

Esr2

estrogen receptor 2

decreases expression

mancozeb results in decreased expression of ESR2 mRNA; mancozeb results in decreased expression of ESR2 protein

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

coagulation factor III, tissue factor

increases expression

mancozeb results in increased expression of F3 protein

PMID:25569083

NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668

Fas

Fas cell surface death receptor

increases expression

mancozeb results in increased expression of FAS protein

PMID:22289270

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

Faslg

Fas ligand

increases expression

mancozeb results in increased expression of FASLG protein

PMID:22289270

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

Gadd45a

growth arrest and DNA-damage-inducible, alpha

multiple interactions
increases expression

lupeol inhibits the reaction [mancozeb results in increased expression of GADD45A mRNA]

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

Glyatl3

glycine-N-acyltransferase-like 3

decreases expression

mancozeb results in decreased expression of GLYATL3 mRNA

NCBI chr 9:19,984,239...19,994,762
Ensembl chr 9:19,977,302...19,995,650

Got1

glutamic-oxaloacetic transaminase 1

affects activity

mancozeb affects the activity of GOT1 protein

PMID:10641187

NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633

Gpt

glutamic--pyruvic transaminase

affects activity

mancozeb affects the activity of GPT protein

PMID:10641187

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

Gpx1

glutathione peroxidase 1

decreases expression
multiple interactions

mancozeb results in decreased expression of GPX1 mRNA
Acetylcysteine inhibits the reaction [mancozeb results in decreased expression of GPX1 mRNA]

PMID:30037311

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

Gsk3b

glycogen synthase kinase 3 beta

multiple interactions

[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

Hdac3

histone deacetylase 3

decreases activity

mancozeb results in decreased activity of HDAC3 protein

NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856

Hdac6

histone deacetylase 6

decreases activity

mancozeb results in decreased activity of HDAC6 protein

NCBI chr X:14,550,645...14,572,445
Ensembl chr X:14,551,044...14,572,441

Hnrnpm

heterogeneous nuclear ribonucleoprotein M

increases expression

mancozeb results in increased expression of HNRNPM protein

NCBI chr 7:14,438,703...14,476,781
Ensembl chr 7:14,438,688...14,476,762

Ifitm2

interferon induced transmembrane protein 2

decreases expression

mancozeb results in decreased expression of IFITM2 mRNA

NCBI chr 1:196,051,539...196,052,719
Ensembl chr 1:196,051,537...196,052,741

Ifng

interferon gamma

multiple interactions

mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]

PMID:15742816

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

Il1b

interleukin 1 beta

multiple interactions

mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]

PMID:16112155

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Il2

interleukin 2

affects expression

mancozeb affects the expression of IL2 protein

PMID:9012323

NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566

Itgb3

integrin subunit beta 3

decreases expression

mancozeb results in decreased expression of ITGB3 mRNA; mancozeb results in decreased expression of ITGB3 protein

NCBI chr10:89,509,917...89,564,679
Ensembl chr10:89,509,989...89,564,679

Kcnq2

potassium voltage-gated channel subfamily Q member 2

increases activity

mancozeb results in increased activity of KCNQ2 protein

PMID:23542819

NCBI chr 3:168,194,776...168,253,831
Ensembl chr 3:168,195,357...168,275,071

Kiss1

KiSS-1 metastasis-suppressor

affects expression

mancozeb affects the expression of KISS1 mRNA

PMID:23660487

NCBI chr13:44,774,823...44,780,707
Ensembl chr13:44,774,823...44,780,612

LOC120094883

small nucleolar RNA SNORD82

increases expression

mancozeb results in increased expression of SNORD82 mRNA

NCBI chr 9:87,004,515...87,004,586
Ensembl chr 9:87,004,515...87,004,586

Ltb4r2

leukotriene B4 receptor 2

increases expression

mancozeb results in increased expression of LTB4R2 mRNA

NCBI chr15:29,258,427...29,260,340
Ensembl chr15:29,259,240...29,260,316

Mapk1

mitogen activated protein kinase 1

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK1 protein]; mancozeb results in increased localization of and results in increased activity of MAPK1 protein

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

Mapk3

mitogen activated protein kinase 3

multiple interactions

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [mancozeb results in increased activity of MAPK3 protein]; mancozeb results in increased localization of and results in increased activity of MAPK3 protein

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

Mdm2

MDM2 proto-oncogene

multiple interactions
increases expression

lupeol inhibits the reaction [mancozeb results in increased expression of MDM2 mRNA]

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

Muc1

mucin 1, cell surface associated

decreases expression

mancozeb results in decreased expression of MUC1 mRNA; mancozeb results in decreased expression of MUC1 protein

NCBI chr 2:174,635,559...174,640,738
Ensembl chr 2:174,635,995...174,640,733

Myc

MYC proto-oncogene, bHLH transcription factor

multiple interactions
increases expression
decreases expression

[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of MYC protein
mancozeb results in increased expression of MYC protein
mancozeb results in decreased expression of MYC protein
alpha-Tocopherol inhibits the reaction [mancozeb results in decreased expression of MYC protein]

PMID:16005924 PMID:19883720

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

Nhlrc1

NHL repeat containing E3 ubiquitin protein ligase 1

decreases expression

mancozeb results in decreased expression of NHLRC1 mRNA

NCBI chr17:17,674,375...17,675,565
Ensembl chr17:17,674,319...17,677,148

Nos2

nitric oxide synthase 2

increases expression
multiple interactions

mancozeb results in increased expression of NOS2 mRNA
Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOS2 mRNA]

PMID:30037311

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

Nox4

NADPH oxidase 4

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [mancozeb results in increased expression of NOX4 mRNA]

PMID:30037311

NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406

Odc1

ornithine decarboxylase 1

increases activity

mancozeb results in increased activity of ODC1 protein

PMID:1733566

NCBI chr 6:40,329,831...40,336,444
Ensembl chr 6:40,329,964...40,336,440

Ogg1

8-oxoguanine DNA glycosylase

multiple interactions
decreases expression

lupeol inhibits the reaction [mancozeb results in decreased expression of OGG1 mRNA]

NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766

Or1s2

olfactory receptor family 1 subfamily S member 2

increases expression

mancozeb results in increased expression of OR1S1 mRNA

NCBI chr 1:210,913,992...210,914,939
Ensembl chr 1:210,911,289...210,915,657

Pcdhb20

protocadherin beta 20

decreases expression

mancozeb results in decreased expression of PCDHB14 mRNA

NCBI chr18:29,211,883...29,215,258
Ensembl chr18:29,211,883...29,215,258

Prdx2

peroxiredoxin 2

increases expression

mancozeb results in increased expression of PRDX2 protein

NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194

Prl

prolactin

multiple interactions
increases expression

[mancozeb co-treated with imidacloprid] results in increased expression of PRL protein
mancozeb results in increased expression of PRL mRNA

PMID:24530807 PMID:33396126

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

Ptges

prostaglandin E synthase

increases expression
decreases expression
multiple interactions

mancozeb results in increased expression of PTGES mRNA
mancozeb results in decreased expression of PTGES protein
lupeol inhibits the reaction [mancozeb results in increased expression of PTGES mRNA]

PMID:27235710 PMID:32446389

NCBI chr 3:14,177,892...14,189,236

Ptges3

prostaglandin E synthase 3

decreases expression

mancozeb results in decreased expression of PTGES3 mRNA

PMID:32446389

NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084

Ptgs2

prostaglandin-endoperoxide synthase 2

increases expression

mancozeb results in increased expression of PTGS2 protein

PMID:21375462 PMID:32446389

NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188

Ptk2b

protein tyrosine kinase 2 beta

multiple interactions

[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form

NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282

Pvalb

parvalbumin

increases expression

mancozeb results in increased expression of PVALB protein

NCBI chr 7:109,772,939...109,787,954
Ensembl chr 7:109,772,593...109,784,561

Rela

RELA proto-oncogene, NF-kB subunit

increases phosphorylation
affects localization
multiple interactions
increases localization

mancozeb results in increased phosphorylation of RELA protein
mancozeb affects the localization of RELA protein
Acetylcysteine inhibits the reaction [mancozeb affects the localization of RELA protein]; lupeol inhibits the reaction [mancozeb affects the localization of RELA protein]; mancozeb inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]
mancozeb results in increased localization of RELA protein

PMID:16112155 PMID:21375462 PMID:22289270 PMID:27235710

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

S100a6

S100 calcium binding protein A6

increases expression

mancozeb results in increased expression of S100A6 protein

NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180

S100a9

S100 calcium binding protein A9

increases expression

mancozeb results in increased expression of S100A9 protein

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

Scx

scleraxis bHLH transcription factor

decreases expression

mancozeb results in decreased expression of SCX mRNA

NCBI chr 7:108,176,608...108,178,626
Ensembl chr 7:108,176,608...108,178,626

Septin11

septin 11

increases expression

mancozeb results in increased expression of SEPTIN11 mRNA

NCBI chr14:14,844,759...14,990,856
Ensembl chr14:14,844,580...14,990,853

Serpinf1

serpin family F member 1

decreases expression

mancozeb results in decreased expression of SERPINF1 mRNA

NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646

Sirt1

sirtuin 1

decreases activity

mancozeb results in decreased activity of SIRT1 protein

NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260

Sirt2

sirtuin 2

decreases activity

mancozeb results in decreased activity of SIRT2 protein

NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975

Sirt3

sirtuin 3

decreases activity

mancozeb results in decreased activity of SIRT3 protein

NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808

Slc14a1

solute carrier family 14 member 1 (Kidd blood group)

decreases expression

mancozeb results in decreased expression of SLC14A1 mRNA

NCBI chr18:71,565,453...71,608,807
Ensembl chr18:71,565,454...71,595,146

Slc5a5

solute carrier family 5 member 5

multiple interactions

mancozeb inhibits the reaction [SLC5A5 protein results in increased uptake of Iodine]

PMID:27979590

NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697

Sod1

superoxide dismutase 1

decreases expression

mancozeb results in decreased expression of SOD1 protein

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

Sult2b1

sulfotransferase family 2B member 1

decreases expression

mancozeb results in decreased expression of SULT2B1 mRNA

NCBI chr 1:96,200,155...96,261,295
Ensembl chr 1:96,200,156...96,261,295

Tek

TEK receptor tyrosine kinase

increases activity

mancozeb results in increased activity of TEK protein

NCBI chr 5:109,607,077...109,733,805
Ensembl chr 5:109,607,077...109,733,804

Tgfb1i1

transforming growth factor beta 1 induced transcript 1

decreases expression

mancozeb results in decreased expression of TGFB1I1 mRNA

NCBI chr 1:182,828,553...182,835,465
Ensembl chr 1:182,828,544...182,837,080

Tnf

tumor necrosis factor

multiple interactions

mancozeb affects the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased secretion of TNF protein]
mancozeb inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; mancozeb inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; mancozeb inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of TNF protein]

PMID:15742816 PMID:15893782 PMID:16112155

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Tp53

tumor protein p53

decreases expression
increases expression
multiple interactions

mancozeb results in decreased expression of TRP53 mRNA; mancozeb results in decreased expression of TRP53 protein
mancozeb results in increased expression of TP53 mRNA
lupeol inhibits the reaction [mancozeb results in increased expression of TP53 mRNA]

PMID:22369882 PMID:27235710

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

Tpi1

triosephosphate isomerase 1

increases expression

mancozeb results in increased expression of TPI1 protein

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

Tpo

thyroid peroxidase

decreases activity

mancozeb results in decreased activity of TPO protein

PMID:9418944

NCBI chr 6:46,698,402...46,768,199
Ensembl chr 6:46,698,414...46,768,199

Tshb

thyroid stimulating hormone subunit beta

multiple interactions

[mancozeb co-treated with imidacloprid] results in increased expression of TSHB protein

PMID:24530807

NCBI chr 2:190,224,676...190,229,559
Ensembl chr 2:190,224,676...190,229,559

Xrcc1

X-ray repair cross complementing 1

decreases expression
multiple interactions

mancozeb results in decreased expression of XRCC1 mRNA
lupeol inhibits the reaction [mancozeb results in decreased expression of XRCC1 mRNA]

NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701

Zfp358

zinc finger protein 358

decreases expression

mancozeb results in decreased expression of ZNF358 mRNA

NCBI chr12:1,552,367...1,556,460
Ensembl chr12:1,552,366...1,556,460

maneb

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Acads

acyl-CoA dehydrogenase short chain

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ACADS mRNA]

NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898

Ache

acetylcholinesterase

decreases expression
multiple interactions

Maneb results in decreased expression of ACHE protein
[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of ACHE mRNA

PMID:3868355 PMID:23017109

NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651

Aco2

aconitase 2

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of ACO2 mRNA

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

Adam22

ADAM metallopeptidase domain 22

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of ADAM22 mRNA

NCBI chr 4:25,716,055...25,970,932
Ensembl chr 4:25,715,990...25,964,962

Adgrb1

adhesion G protein-coupled receptor B1

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of ADGRB1 mRNA

NCBI chr 7:106,404,844...106,476,902
Ensembl chr 7:106,404,958...106,476,902

Adgrg1

adhesion G protein-coupled receptor G1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of ADGRG1 mRNA

NCBI chr19:10,003,963...10,041,122
Ensembl chr19:10,003,975...10,041,108

Adora1

adenosine A1 receptor

multiple interactions

[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ADORA1 mRNA

NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801

Ago3

argonaute RISC catalytic component 3

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of AGO3 mRNA

NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230

Aif1

allograft inflammatory factor 1

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of AIF1 protein; [Paraquat co-treated with Maneb] results in increased expression of AIF1 protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of AIF1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of AIF1 protein]

PMID:28202386 PMID:32375810

NCBI chr20:3,646,784...3,652,670
Ensembl chr20:3,646,777...3,652,668

Akr1b1

aldo-keto reductase family 1 member B1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of AKR1B3 mRNA

NCBI chr 4:62,932,033...62,946,126
Ensembl chr 4:62,932,031...62,946,157

Akt1

AKT serine/threonine kinase 1

multiple interactions

[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of AKT1 protein; [alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of AKT1 protein; [Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of AKT1 mRNA]

PMID:19883720 PMID:23963992

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

Alas2

5'-aminolevulinate synthase 2

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of ALAS2 mRNA

NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519

Aldh2

aldehyde dehydrogenase 2 family member

decreases activity

Maneb results in decreased activity of ALDH2 protein

PMID:17010440

NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521

Aldh5a1

aldehyde dehydrogenase 5 family, member A1

decreases activity
multiple interactions

Maneb results in decreased activity of ALDH5A1 protein
[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ALDH5A1 mRNA]

PMID:17010440 PMID:23963992

NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677

Aldoc

aldolase, fructose-bisphosphate C

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of ALDOC mRNA

NCBI chr10:63,217,477...63,221,066
Ensembl chr10:63,217,451...63,221,066

Amn

amnion associated transmembrane protein

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of AMN mRNA

NCBI chr 6:130,311,372...130,318,815
Ensembl chr 6:130,311,372...130,318,815

Ap3b2

adaptor related protein complex 3 subunit beta 2

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of AP3B2 mRNA

NCBI chr 1:135,412,580...135,445,191
Ensembl chr 1:135,412,580...135,445,191

Ap3d1

adaptor related protein complex 3 subunit delta 1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of AP3D1 mRNA

NCBI chr 7:8,970,249...9,005,651
Ensembl chr 7:8,970,291...9,005,643

Apbb1

amyloid beta precursor protein binding family B member 1

multiple interactions

[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of APBB1 mRNA

NCBI chr 1:159,896,889...159,920,505
Ensembl chr 1:159,896,880...159,920,627

Arf3

ADP-ribosylation factor 3

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of ARF3 mRNA

NCBI chr 7:129,886,082...129,912,022
Ensembl chr 7:129,886,082...129,912,002

Arg1

arginase 1

decreases expression
multiple interactions

Maneb results in decreased expression of ARG1 mRNA
[Maneb co-treated with Paraquat] results in increased expression of ARG1 mRNA; [Paraquat co-treated with Maneb] results in increased expression of ARG1 mRNA; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ARG1 mRNA]

PMID:29568078 PMID:32194361 PMID:32375810 PMID:34052309

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

Arnt2

aryl hydrocarbon receptor nuclear translocator 2

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of ARNT2 mRNA

NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153

Ascl1

achaete-scute family bHLH transcription factor 1

multiple interactions

[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ASCL1 mRNA

NCBI chr 7:21,904,153...21,906,003
Ensembl chr 7:21,903,126...21,905,993

Atg12

autophagy related 12

multiple interactions

Maneb promotes the reaction [Paraquat results in increased expression of ATG12 protein]

PMID:22292029

NCBI chr18:39,452,247...39,462,424
Ensembl chr18:39,452,191...39,462,418

Atp5f1a

ATP synthase F1 subunit alpha

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP5A1 protein]

NCBI chr18:71,292,406...71,300,342
Ensembl chr18:71,292,374...71,300,794

Atp5mc1

ATP synthase membrane subunit c locus 1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of ATP5G1 mRNA

NCBI chr10:81,024,056...81,026,780
Ensembl chr10:81,023,925...81,027,124
Ensembl chr10:81,023,925...81,027,124

Atp6v0b

ATPase H+ transporting V0 subunit B

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of ATP6V0B mRNA

NCBI chr 5:131,423,384...131,424,900
Ensembl chr 5:131,423,387...131,426,401

Atp6v0c

ATPase H+ transporting V0 subunit C

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of ATP6V0C mRNA

NCBI chr10:13,196,204...13,202,580
Ensembl chr10:13,196,204...13,201,500

Atp6v1c1

ATPase H+ transporting V1 subunit C1

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ATP6V1C1 mRNA]

NCBI chr 7:69,834,464...69,872,278
Ensembl chr 7:69,834,463...69,872,278

Atp8a2

ATPase phospholipid transporting 8A2

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of ATP8A2 mRNA

NCBI chr15:33,817,309...34,350,193
Ensembl chr15:33,819,755...34,350,223

Bad

BCL2-associated agonist of cell death

multiple interactions

[Paraquat co-treated with Maneb] results in increased phosphorylation of BAD protein

PMID:15824117

NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823

Bak1

BCL2-antagonist/killer 1

multiple interactions
increases expression
affects response to substance

[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAK1 mRNA]
[Paraquat co-treated with Maneb] results in increased expression of BAK1 protein; Maneb inhibits the reaction [BAK1 protein affects the susceptibility to Paraquat]; Paraquat inhibits the reaction [BAK1 protein affects the susceptibility to Maneb]
Maneb results in increased expression of BAK1 mRNA; Maneb results in increased expression of BAK1 protein

PMID:18266926 PMID:23963992

NCBI chr20:5,100,480...5,109,669
Ensembl chr20:5,100,480...5,109,264

Bax

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[Paraquat co-treated with Maneb] results in increased expression of BAX protein; BAX protein affects the susceptibility to [Paraquat co-treated with Maneb]
Maneb results in increased expression of BAX protein
[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA; [Paraquat co-treated with Maneb] results in increased expression of BAX protein; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of BAX mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BAX protein]

PMID:15824117 PMID:18266926 PMID:20964710 PMID:23963992

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

Bbc3

Bcl-2 binding component 3

increases expression
multiple interactions

Maneb results in increased expression of BBC3 protein
3-(4-(morpholin-4-yl)-7H-pyrrolo(2,3-d)pyrimidin-5-yl)benzonitrile inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BBC3 protein]; [Paraquat co-treated with Maneb] results in increased expression of BBC3 protein; Plant Extracts inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of BBC3 protein]

PMID:18266926 PMID:34897981

NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509

Bcl2

BCL2, apoptosis regulator

multiple interactions
increases expression

[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of BCL2 mRNA]
Maneb results in increased expression of BCL2 mRNA; Maneb results in increased expression of BCL2 protein

PMID:18266926 PMID:23963992

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

Bcl2a1

BCL2-related protein A1

increases expression
multiple interactions

Maneb results in increased expression of BCL2A1 mRNA
[Paraquat co-treated with Maneb] results in increased expression of BCL2A1 protein

NCBI chr 8:89,716,914...89,724,998
Ensembl chr 8:89,716,914...89,724,998

Bcl2l1

Bcl2-like 1

multiple interactions
increases expression

[Paraquat co-treated with Maneb] results in decreased expression of BCL2L1 protein
Maneb results in increased expression of BCL2L1 mRNA

PMID:15824117 PMID:18266926

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

Bcl2l11

Bcl2-like 11

increases expression
multiple interactions

Maneb results in increased expression of BCL2L11 protein
[Paraquat co-treated with Maneb] results in increased expression of BCL2L11 protein

NCBI chr 3:115,366,783...115,404,068
Ensembl chr 3:115,366,646...115,404,068

Bdnf

brain-derived neurotrophic factor

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of BDNF mRNA
[Paraquat co-treated with Maneb] results in decreased expression of BDNF mRNA; [Paraquat co-treated with Maneb] results in decreased expression of BDNF protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of BDNF mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of BDNF protein]

PMID:23017109 PMID:27460631 PMID:33368748

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

Becn1

beclin 1

increases expression
multiple interactions

Maneb results in increased expression of BECN1 protein
[Paraquat co-treated with Maneb] results in increased expression of BECN1 protein

PMID:22292029 PMID:26884967

NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742

Bicd1

BICD cargo adaptor 1

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of BICD1 mRNA

NCBI chr 4:182,479,071...182,631,504
Ensembl chr 4:182,479,071...182,627,434

Bid

BH3 interacting domain death agonist

increases expression
multiple interactions

Maneb results in increased expression of BID protein
[Maneb co-treated with Paraquat] results in increased expression of BID protein

NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720

Bik

BCL2-interacting killer

increases expression
multiple interactions

Maneb results in increased expression of BIK mRNA; Maneb results in increased expression of BIK protein
[Paraquat co-treated with Maneb] results in increased expression of BIK protein

NCBI chr 7:114,672,277...114,691,296
Ensembl chr 7:114,672,277...114,691,296

Bmp2

bone morphogenetic protein 2

multiple interactions

[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP2 mRNA

NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397

Bmp4

bone morphogenetic protein 4

multiple interactions

[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA

NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306

Bnip3

BCL2 interacting protein 3

increases expression

Maneb results in increased expression of BNIP3 mRNA; Maneb results in increased expression of BNIP3 protein

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

Bnip3l

BCL2 interacting protein 3 like

increases expression

Maneb results in increased expression of BNIP3L mRNA

NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803

Brf1

BRF1, RNA polymerase III transcription initiation factor subunit

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of BRF1 mRNA

NCBI chr 6:132,034,380...132,081,296
Ensembl chr 6:132,037,272...132,081,278

Cacna1e

calcium voltage-gated channel subunit alpha1 E

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of CACNA1E mRNA

NCBI chr13:66,574,659...67,063,443
Ensembl chr13:66,581,920...66,894,450

Cacybp

calcyclin binding protein

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of CACYBP mRNA

NCBI chr13:72,437,485...72,447,810
Ensembl chr13:72,437,490...72,450,177

Calm1

calmodulin 1

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CALM1 mRNA]

NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227

Calm2

calmodulin 2

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of CALM2 mRNA

NCBI chr 6:7,091,624...7,104,284
Ensembl chr 6:7,091,567...7,104,287

Camp

cathelicidin antimicrobial peptide

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of CAMP mRNA
[Paraquat co-treated with Maneb] results in decreased expression of CAMP mRNA

PMID:22563483 PMID:27460631

NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543

Capn11

calpain 11

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of CAPN11 mRNA

NCBI chr 9:15,344,059...15,365,604
Ensembl chr 9:15,344,089...15,365,601

Casp1

caspase 1

multiple interactions

[Maneb co-treated with Paraquat] results in increased cleavage of CASP1 protein; [Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA; [Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased cleavage of CASP1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP1 mRNA]

PMID:23963992 PMID:32375810 PMID:34052309

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

Casp3

caspase 3

increases activity
multiple interactions

Maneb results in increased activity of CASP3 protein
3-(4-(morpholin-4-yl)-7H-pyrrolo(2,3-d)pyrimidin-5-yl)benzonitrile inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP3 protein modified form]; [Paraquat co-treated with Maneb] results in increased expression of CASP3 protein modified form; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP3 protein modified form]; Plant Extracts inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP3 protein modified form]

PMID:22824503 PMID:34897981

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Casp7

caspase 7

increases activity

Maneb results in increased activity of CASP7 protein

PMID:22824503

NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729

Casp8

caspase 8

increases activity

Maneb results in increased activity of CASP8 protein

PMID:22824503

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

Casp9

caspase 9

multiple interactions
increases activity

[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA; [Paraquat co-treated with Maneb] results in increased expression of CASP9 protein; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP9 protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CASP9 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CASP9 protein]
Maneb results in increased activity of CASP9 protein

PMID:20964710 PMID:22824503 PMID:23963992

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

Cat

catalase

decreases activity
multiple interactions

Maneb results in decreased activity of CAT protein
[Maneb co-treated with Paraquat] results in increased expression of CAT mRNA

PMID:26210702 PMID:29859004

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

Ccdc88a

coiled coil domain containing 88A

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of CCDC88A mRNA

NCBI chr14:103,104,091...103,256,112
Ensembl chr14:103,103,513...103,252,368

Ccl19

C-C motif chemokine ligand 19

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of CCL19 mRNA

NCBI chr 5:56,963,364...56,965,308
Ensembl chr 5:56,963,364...56,965,308

Ccl21

C-C motif chemokine ligand 21

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of CCL21 mRNA; [Paraquat co-treated with Maneb] affects the expression of CCL21A mRNA

NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686

Ccnd1

cyclin D1

multiple interactions

[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of CCND1 protein
[Maneb co-treated with Paraquat] results in decreased expression of CCND1 mRNA

PMID:19883720 PMID:29859004

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

Ccnd2

cyclin D2

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of CCND2 mRNA

PMID:29859004

NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495

Cd34

CD34 molecule

increases expression

Maneb results in increased expression of CD34

PMID:25803990

NCBI chr13:106,480,074...106,499,462
Ensembl chr13:106,480,043...106,499,832

Cd68

Cd68 molecule

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of CD68 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CD68 mRNA]

NCBI chr10:54,381,814...54,383,693
Ensembl chr10:54,381,815...54,383,697

Cdhr4

cadherin-related family member 4

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of CDHR4 mRNA

NCBI chr 8:108,682,594...108,690,358
Ensembl chr 8:108,682,613...108,690,367

Cdipt

CDP-diacylglycerol--inositol 3-phosphatidyltransferase

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of CDIPT mRNA

NCBI chr 1:181,583,098...181,587,409
Ensembl chr 1:181,583,141...181,587,408

Cdk2

cyclin dependent kinase 2

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CDK2 mRNA]

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

Cdk5r1

cyclin-dependent kinase 5 regulatory subunit 1

multiple interactions

[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5R1 mRNA

NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456

Cdk5rap1

CDK5 regulatory subunit associated protein 1

multiple interactions

[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5RAP1 mRNA

NCBI chr 3:142,838,081...142,872,669
Ensembl chr 3:142,708,028...142,872,677

Cdk5rap2

CDK5 regulatory subunit associated protein 2

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA; LRRK2 protein mutant form inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA]; SNCA protein inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA]

NCBI chr 5:83,792,282...83,961,129
Ensembl chr 5:83,792,284...83,960,782

Cdkn1a

cyclin-dependent kinase inhibitor 1A

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of CDKN1A mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDKN1A mRNA]

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

Cdkn2a

cyclin-dependent kinase inhibitor 2A

multiple interactions
increases expression

[Maneb co-treated with Paraquat] results in increased expression of CDKN2A mRNA
Maneb results in increased expression of CDKN2A mRNA

PMID:29859004

NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149

Cebpd

CCAAT/enhancer binding protein delta

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of CEBPD mRNA

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

Cep290

centrosomal protein 290

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of CEP290 mRNA

NCBI chr 7:35,310,071...35,399,392
Ensembl chr 7:35,310,199...35,399,392

Chrm2

cholinergic receptor, muscarinic 2

multiple interactions

[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CHRM2 mRNA

NCBI chr 4:65,015,408...65,149,104
Ensembl chr 4:65,014,144...65,149,103

Chuk

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

[Paraquat co-treated with Maneb] results in increased phosphorylation of CHUK protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of CHUK protein]

PMID:29568078

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

Cirbp

cold inducible RNA binding protein

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of CIRBP mRNA

NCBI chr 7:9,533,857...9,538,899
Ensembl chr 7:9,424,178...9,538,818

Clca1

chloride channel accessory 1

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of CLCA1 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CLCA1 mRNA]

NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369

Clu

clusterin

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of CLU mRNA

NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315

Cope

COPI coat complex subunit epsilon

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of COPE mRNA

NCBI chr16:19,114,871...19,125,527
Ensembl chr16:19,114,871...19,128,907

Cox5a

cytochrome c oxidase subunit 5A

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX5A protein]

NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781

Cox6a1

cytochrome c oxidase subunit 6A1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of COX6A1 mRNA

NCBI chr12:41,261,983...41,265,037
Ensembl chr12:41,261,967...41,265,041

Cox6b1

cytochrome c oxidase subunit 6B1

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of COX6B1 mRNA]

NCBI chr 1:85,875,080...85,884,081
Ensembl chr 1:85,875,109...85,884,001

Cox7a2

cytochrome c oxidase subunit 7A2

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of COX7A2 mRNA

NCBI chr 8:80,716,824...80,720,922
Ensembl chr14:51,301,168...51,301,633

Cox7a2l

cytochrome c oxidase subunit 7A2 like

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of COX7A2L mRNA

NCBI chr 6:11,184,284...11,198,287
Ensembl chr 6:11,184,285...11,198,273

Cplx1

complexin 1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of CPLX1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of CPLX1 protein

PMID:17532186

NCBI chr14:1,184,638...1,216,392

Creb1

cAMP responsive element binding protein 1

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of CREB1 mRNA]
[Paraquat co-treated with Maneb] results in decreased expression of and results in decreased phosphorylation of CREB1 protein; [Paraquat co-treated with Maneb] results in decreased expression of CREB1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of CREB1 protein; [Paraquat co-treated with Maneb] results in decreased expression of CREB1 protein modified form; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of and results in decreased phosphorylation of CREB1 protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of CREB1 mRNA]

PMID:23963992 PMID:27460631 PMID:33368748

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

Crip2

cysteine-rich protein 2

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of CRIP2 mRNA

NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065

Crlf2

cytokine receptor-like factor 2

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of CRLF2 mRNA

NCBI chr14:103,943...108,643
Ensembl chr14:103,939...108,642

Crot

carnitine O-octanoyltransferase

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of CROT mRNA

NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109

Csf1r

colony stimulating factor 1 receptor

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of CSF1R mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF1R mRNA]

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

Csf2ra

colony stimulating factor 2 receptor subunit alpha

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of CSF2RA mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CSF2RA mRNA]

NCBI chr14:98,089...103,261
Ensembl chr14:89,172...103,128

Ctsl

cathepsin L

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of CTSL mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CTSL mRNA]

NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548

Cybb

cytochrome b-245 beta chain

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of CYBB mRNA; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB mRNA]; diphenyleneiodonium inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB mRNA]
[Maneb co-treated with Paraquat] results in increased expression of CYBB protein; [Paraquat co-treated with Maneb] results in increased expression of CYBB protein; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CYBB protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYBB protein]

PMID:29568078 PMID:30797899 PMID:32375810 PMID:34052309

NCBI chr X:13,360,583...13,392,517
Ensembl chr X:13,359,430...13,392,586

Cyc1

cytochrome c-1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of CYC1 mRNA

NCBI chr 7:108,067,106...108,069,483
Ensembl chr 7:108,067,115...108,069,479

Cyp1a1

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
decreases expression
increases expression

Maneb results in increased activity of CYP1A1 protein
Maneb results in decreased expression of CYP1A1 mRNA
Maneb results in increased expression of CYP1A1 mRNA; Maneb results in increased expression of CYP1A1 protein

PMID:20888808 PMID:32194361

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

Cyp1a2

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein; [Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of CYP1A2 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP1A2 mRNA]

PMID:23159886

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

Cyp2c6v1

cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1

decreases expression

Maneb results in decreased expression of CYP2C19 protein

PMID:32194361

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

Cyp2d4

cytochrome P450, family 2, subfamily d, polypeptide 4

multiple interactions
decreases expression

Ketoconazole inhibits the reaction [Maneb results in decreased expression of CYP2D22 protein]

PMID:22334051

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

Cyp2e1

cytochrome P450, family 2, subfamily e, polypeptide 1

decreases activity
increases expression
multiple interactions
increases activity

Maneb results in decreased activity of CYP2E1 protein
Maneb results in increased expression of CYP2E1 mRNA; Maneb results in increased expression of CYP2E1 protein
[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein; [Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA; Acetylcysteine inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA]; Maneb results in increased expression of and results in increased activity of CYP2E1 protein; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of and results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Silymarin inhibits the reaction [Maneb results in increased expression of and results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [Maneb results in increased expression of CYP2E1 mRNA]
Maneb results in increased activity of CYP2E1 protein
[Maneb co-treated with Paraquat] results in increased expression of CYP2E1 mRNA; [Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein; [Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of CYP2E1 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of CYP2E1 mRNA]

PMID:11043497 PMID:16510128 PMID:20888808 PMID:20964710 PMID:23159886

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

Cyp7a1

cytochrome P450 family 7 subfamily A member 1

decreases expression

Maneb results in decreased expression of CYP7A1 mRNA

PMID:32194361

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

Dap3

death associated protein 3

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of DAP3 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DAP3 mRNA]

NCBI chr 2:174,319,341...174,347,489
Ensembl chr 2:174,318,983...174,346,461

Dbi

diazepam binding inhibitor

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of DBI mRNA

NCBI chr13:31,241,466...31,249,853
Ensembl chr13:31,206,988...31,268,693

Ddit4

DNA-damage-inducible transcript 4

increases expression

Maneb results in increased expression of DDIT4 protein

PMID:24764117

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

Ddx5

DEAD-box helicase 5

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of DDX5 mRNA

NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283

Dgki

diacylglycerol kinase, iota

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of DGKI mRNA

NCBI chr 4:65,410,878...65,872,733
Ensembl chr 4:65,420,108...65,872,733

Dio1

iodothyronine deiodinase 1

decreases activity

Maneb results in decreased activity of DIO1 protein

PMID:29228274

NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970

Dip2b

disco-interacting protein 2 homolog B

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of DIP2B mRNA

NCBI chr 7:131,174,575...131,350,417
Ensembl chr 7:131,174,567...131,349,092

Dll1

delta like canonical Notch ligand 1

multiple interactions

[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DLL1 mRNA

NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179

Dlst

dihydrolipoamide S-succinyltransferase

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of DLST protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of DLST protein]

NCBI chr 6:104,758,511...104,783,296
Ensembl chr 6:104,758,631...104,783,296

Dmrta2

DMRT-like family A2

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of DMRTA2 mRNA

NCBI chr 5:124,805,883...124,811,694
Ensembl chr 5:124,805,883...124,811,630

Dnajb6

DnaJ heat shock protein family (Hsp40) member B6

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of DNAJB6 mRNA

NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659

Dnm2

dynamin 2

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of DNM2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of DNM2 mRNA]

NCBI chr 8:19,978,313...20,060,162
Ensembl chr 8:19,978,400...20,060,157

Drd2

dopamine receptor D2

multiple interactions

[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD2 mRNA

NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875

Drd4

dopamine receptor D4

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of DRD4 protein

NCBI chr 1:196,396,366...196,400,824
Ensembl chr 1:196,396,366...196,399,553

Drd5

dopamine receptor D5

multiple interactions

[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD5 mRNA

NCBI chr14:72,489,347...72,490,774
Ensembl chr14:72,489,347...72,490,774

E2f1

E2F transcription factor 1

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of E2F1 mRNA]

NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361

Eef1a1

eukaryotic translation elongation factor 1 alpha 1

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of EEF1A1 mRNA

NCBI chr 8:79,341,554...79,344,784
Ensembl chr 8:79,341,557...79,344,839

Eef1g

eukaryotic translation elongation factor 1 gamma

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EEF1G mRNA]

NCBI chr 1:205,860,713...205,871,319
Ensembl chr 1:205,860,698...205,872,382

Efnb1

ephrin B1

multiple interactions

[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of EFNB1 mRNA

NCBI chr X:64,257,351...64,270,158
Ensembl chr X:64,257,351...64,270,157

Egr4

early growth response 4

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of EGR4 mRNA

NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328

Eif4g2

eukaryotic translation initiation factor 4, gamma 2

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of EIF4G2 mRNA]

NCBI chr 1:165,181,433...165,193,583
Ensembl chr 1:165,181,434...165,193,588

Elk1

ETS transcription factor ELK1

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of ELK1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ELK1 mRNA]

NCBI chr X:1,138,826...1,155,713
Ensembl chr X:1,139,756...1,155,713

Eno1

enolase 1

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of ENO1 protein; [Paraquat co-treated with Maneb] results in decreased expression of ENO1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of ENO1 protein; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ENO1 protein]

PMID:17532186 PMID:18386188 PMID:23562983

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336

Eno2

enolase 2

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of ENO2 protein

NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980

Etl4

enhancer trap locus 4

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of ETL4 mRNA

NCBI chr17:82,841,075...83,304,868
Ensembl chr17:82,495,041...83,304,715

Fas

Fas cell surface death receptor

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FAS mRNA]

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

Fez1

fasciculation and elongation protein zeta 1

multiple interactions

[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of FEZ1 mRNA

NCBI chr 8:36,544,462...36,589,684
Ensembl chr 8:36,544,535...36,589,683

Fgfr3

fibroblast growth factor receptor 3

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of FGFR3 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FGFR3 mRNA]

NCBI chr14:76,987,242...77,002,671
Ensembl chr14:76,987,993...77,003,341

Fkbp4

FKBP prolyl isomerase 4

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of FKBP4 mRNA

NCBI chr 4:161,703,379...161,711,833
Ensembl chr 4:161,703,379...161,711,833

Fkbp5

FKBP prolyl isomerase 5

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of FKBP5 mRNA

NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674

Fos

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of FOS mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of FOS mRNA]
[Paraquat co-treated with Maneb] results in decreased expression of FOS mRNA; [Paraquat co-treated with Maneb] results in decreased expression of FOS protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of FOS mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of FOS protein]

PMID:23963992 PMID:27460631 PMID:33368748

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

Fxyd6

FXYD domain-containing ion transport regulator 6

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of FXYD6 mRNA

NCBI chr 8:45,679,054...45,705,958
Ensembl chr 8:45,678,885...45,705,958

G6pc1

glucose-6-phosphatase catalytic subunit 1

decreases expression

Maneb results in decreased expression of G6PC1 mRNA

PMID:32194361

NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804

Gabra6

gamma-aminobutyric acid type A receptor subunit alpha6

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of GABRA6 mRNA

NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769

Gas5

growth arrest specific 5

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of GAS5 mRNA

NCBI chr13:73,303,611...73,306,932

Gclc

glutamate-cysteine ligase, catalytic subunit

increases expression
increases activity

[Maneb results in increased expression of NFE2L2 protein] which results in increased expression of GCLC mRNA
Maneb results in increased activity of GCLC protein

PMID:15527874 PMID:21402726

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

Gfap

glial fibrillary acidic protein

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of GFAP protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of GFAP protein]

PMID:30797899

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

Gh1

growth hormone 1

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of GH mRNA

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

Gm2a

ganglioside GM2 activator

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of GM2A mRNA

NCBI chr10:39,219,221...39,231,756
Ensembl chr10:39,219,243...39,231,757

Gmfb

glia maturation factor, beta

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of GMFB mRNA; [Paraquat co-treated with Maneb] results in decreased expression of GMFB protein

PMID:17532186

NCBI chr15:20,069,923...20,081,005
Ensembl chr15:20,067,263...20,080,331

Gng5

G protein subunit gamma 5

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of GNG5 mRNA

NCBI chr 2:235,394,680...235,403,177
Ensembl chr 1:77,292,043...77,292,513

Gngt2

G protein subunit gamma transducin 2

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of GNGT2 mRNA

NCBI chr10:80,776,003...80,784,235

Gpr27

G protein-coupled receptor 27

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of GPR27 mRNA

NCBI chr 4:132,328,364...132,329,497
Ensembl chr 4:132,328,364...132,329,497

Gpx1

glutathione peroxidase 1

multiple interactions
decreases expression

GPX1 protein results in decreased susceptibility to [Paraquat co-treated with Maneb]
[Maneb co-treated with Paraquat] results in increased expression of GPX1 mRNA
Maneb results in decreased expression of GPX1 mRNA

PMID:15824117 PMID:26210702 PMID:29859004

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

Gpx4

glutathione peroxidase 4

increases expression
multiple interactions

Maneb results in increased expression of GPX4 mRNA
[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein
[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of GPX4 protein]; NFE2L2 gene mutant form inhibits the reaction [Maneb results in increased expression of GPX4 mRNA]

PMID:23764462 PMID:30797899

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

Grb2

growth factor receptor bound protein 2

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GRB2 mRNA]

NCBI chr10:100,881,404...100,949,193
Ensembl chr10:100,869,718...100,949,309

Gsk3b

glycogen synthase kinase 3 beta

multiple interactions

[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] affects the phosphorylation of GSK3B protein

NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646

Gsr

glutathione-disulfide reductase

multiple interactions

[Acetylcysteine co-treated with Paraquat co-treated with Maneb] results in increased activity of GSR protein; [Silymarin co-treated with Maneb] results in increased activity of GSR protein; [Silymarin co-treated with Paraquat co-treated with Maneb] results in increased activity of GSR protein
[NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased expression of GSR protein

PMID:23159886 PMID:23764462

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

Gsta3

glutathione S-transferase alpha 3

increases expression

Maneb results in increased expression of GSTA3 mRNA

PMID:20888808

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

Gsta4

glutathione S-transferase alpha 4

multiple interactions
increases activity
increases expression

[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein; [Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA; Acetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]; Acetylcysteine promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]; Acetylcysteine promotes the reaction [Maneb results in increased expression of and results in increased activity of GSTA4 protein]; Acetylcysteine promotes the reaction [Maneb results in increased expression of GSTA4 mRNA]; Maneb results in increased expression of and results in increased activity of GSTA4 protein; Silymarin promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of and results in increased activity of GSTA4 protein]; Silymarin promotes the reaction [[Paraquat co-treated with Maneb] results in increased expression of GSTA4 mRNA]; Silymarin promotes the reaction [Maneb results in increased expression of and results in increased activity of GSTA4 protein]; Silymarin promotes the reaction [Maneb results in increased expression of GSTA4 mRNA]
Maneb results in increased activity of GSTA4 protein
Maneb results in increased expression of GSTA4 mRNA; Maneb results in increased expression of GSTA4 protein

PMID:20888808 PMID:23159886

NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182

Gstp1

glutathione S-transferase pi 1

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of GSTP1 mRNA]

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

Guk1

guanylate kinase 1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of GUK1 mRNA

NCBI chr10:43,971,514...43,988,658
Ensembl chr10:43,971,509...43,980,107

H2ac20

H2A clustered histone 20

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of H2AC20 mRNA

NCBI chr 2:183,779,879...183,780,324

H2bc9

H2B clustered histone 9

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of H2BC9 mRNA

NCBI chr17:42,470,593...42,478,605

Hba-a1

hemoglobin alpha, adult chain 1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of HBA-A1 mRNA

NCBI chr10:15,337,265...15,338,121
Ensembl chr10:15,307,815...15,338,392

Hdac3

histone deacetylase 3

decreases activity

Maneb results in decreased activity of HDAC3 protein

NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856

Hdac6

histone deacetylase 6

decreases activity

Maneb results in decreased activity of HDAC6 protein

NCBI chr X:14,550,645...14,572,445
Ensembl chr X:14,551,044...14,572,441

Hes3

hes family bHLH transcription factor 3

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of HES3 mRNA

NCBI chr 5:162,793,611...162,799,578
Ensembl chr 5:162,794,367...162,796,261

Hey2

hes-related family bHLH transcription factor with YRPW motif 2

multiple interactions

[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEY2 mRNA

NCBI chr 1:26,822,131...26,832,218
Ensembl chr 1:26,822,131...26,832,218

Heyl

hes-related family bHLH transcription factor with YRPW motif-like

multiple interactions

[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEYL mRNA

NCBI chr 5:135,508,160...135,525,152
Ensembl chr 5:135,508,160...135,525,152

Hk1

hexokinase 1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of HK1 mRNA

NCBI chr20:30,230,488...30,332,161
Ensembl chr20:30,230,486...30,332,131

Hmga2

high mobility group AT-hook 2

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of HMGA2 mRNA

NCBI chr 7:55,877,145...55,998,813
Ensembl chr 7:55,880,112...55,994,784

Hmgn5

high mobility group nucleosome binding domain 5

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of HMGN5 mRNA

NCBI chr X:74,085,871...74,094,488

Hmox1

heme oxygenase 1

increases expression
multiple interactions

Maneb results in increased expression of HMOX1 protein
[NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased expression of HMOX1 protein

PMID:15527874 PMID:23764462

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

Hnrnpk

heterogeneous nuclear ribonucleoprotein K

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of HNRNPK mRNA

NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997

Hsd11b2

hydroxysteroid 11-beta dehydrogenase 2

decreases activity

Maneb results in decreased activity of HSD11B2 protein

PMID:22796344

NCBI chr19:33,397,656...33,402,899
Ensembl chr19:33,397,656...33,402,899

Hsf1

heat shock transcription factor 1

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSF1 mRNA]

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

Hsp90aa1

heat shock protein 90 alpha family class A member 1

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA; [Paraquat co-treated with Maneb] results in increased expression of HSP90AA1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA]

PMID:18386188 PMID:23963992

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

Hspa1a

heat shock protein family A (Hsp70) member 1A

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of HSPA1B mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of HSPA1B mRNA]

NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240

Hspa5

heat shock protein family A (Hsp70) member 5

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of HSPA5 mRNA

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

Hspa8

heat shock protein family A (Hsp70) member 8

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of HSPA8 mRNA

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

Icam1

intercellular adhesion molecule 1

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of ICAM1 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ICAM1 mRNA]

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

Icam2

intercellular adhesion molecule 2

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of ICAM2 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ICAM2 mRNA]

NCBI chr10:91,308,608...91,319,536
Ensembl chr10:91,308,538...91,315,293

Idh3a

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of IDH3A protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IDH3A protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IDH3A protein]

NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084

Ier5l

immediate early response 5-like

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of IER5L mRNA

NCBI chr 3:13,744,056...13,745,647
Ensembl chr 3:13,744,078...13,745,647

Ifng

interferon gamma

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of IFNG mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IFNG mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IFNG mRNA]

NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375

Igf1

insulin-like growth factor 1

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IGF1 mRNA]

NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296

Il1b

interleukin 1 beta

multiple interactions
increases expression

[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; Silymarin inhibits the reaction [Maneb results in increased expression of IL1B mRNA]
[Maneb co-treated with Paraquat] results in increased expression of IL1B mRNA; [Maneb co-treated with Paraquat] results in increased expression of IL1B protein; [Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA; [Paraquat co-treated with Maneb] results in increased expression of IL1B protein; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B mRNA]; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of IL1B mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]

PMID:23159886 PMID:23963992 PMID:29568078 PMID:32169474 PMID:32375810 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

Il6

interleukin 6

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of IL6 mRNA; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL6 mRNA]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

Inhba

inhibin subunit beta A

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of INHBA mRNA; [Paraquat co-treated with Maneb] affects the expression of INHBA mRNA

PMID:22563483 PMID:23017109

NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982

Irs2

insulin receptor substrate 2

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of IRS2 mRNA]

NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482

Itgam

integrin subunit alpha M

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of ITGAM protein; [Paraquat co-treated with Maneb] results in increased expression of ITGAM mRNA; [Paraquat co-treated with Maneb] results in increased expression of ITGAM protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of ITGAM protein]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ITGAM protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased cleavage of CASP1 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B mRNA]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of IL1B protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of ITGAM mRNA]

PMID:28202386 PMID:30797899 PMID:32169474 PMID:32375810

NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503

Itgb8

integrin subunit beta 8

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of ITGB8 mRNA

NCBI chr 6:140,124,997...140,208,254
Ensembl chr 6:140,127,203...140,208,476

Itpr1

inositol 1,4,5-trisphosphate receptor, type 1

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of ITPR1 mRNA]

NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491

Jpt1

Jupiter microtubule associated homolog 1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of JPT1 mRNA

NCBI chr10:100,744,468...100,762,504
Ensembl chr10:100,686,797...100,784,513

Jun

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of JUN mRNA; [Paraquat co-treated with Maneb] results in decreased expression of JUN protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of JUN mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of JUN protein]

PMID:27460631 PMID:33368748

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

Kcna2

potassium voltage-gated channel subfamily A member 2

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of KCNA2 mRNA

NCBI chr 2:194,704,555...194,718,387
Ensembl chr 2:194,704,639...194,718,400

Kcnma1

potassium calcium-activated channel subfamily M alpha 1

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of KCNMA1 mRNA

NCBI chr15:302,078...1,001,198
Ensembl chr15:302,214...1,001,198

Kif1b

kinesin family member 1B

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of KIF1B mRNA

NCBI chr 5:159,607,697...159,742,778
Ensembl chr 5:159,561,271...159,742,778

Kit

KIT proto-oncogene receptor tyrosine kinase

decreases expression

Maneb results in decreased expression of KIT

PMID:25803990

NCBI chr14:32,547,459...32,624,694
Ensembl chr14:32,548,877...32,624,652

Klf2

KLF transcription factor 2

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of KLF2 mRNA

NCBI chr16:17,521,773...17,523,723
Ensembl chr16:17,514,552...17,523,944

Klhl15

kelch-like family member 15

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of KLHL15 mRNA

NCBI chr X:58,994,726...59,050,207
Ensembl chr X:58,995,461...59,046,069

Lamc2

laminin subunit gamma 2

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of LAMC2 mRNA

NCBI chr13:65,284,664...65,344,200
Ensembl chr13:65,284,664...65,344,200

Lifr

LIF receptor subunit alpha

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of LIFR mRNA

NCBI chr 2:56,224,393...56,292,988
Ensembl chr 2:56,250,120...56,286,699

Limk2

LIM domain kinase 2

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of LIMK2 mRNA

NCBI chr14:78,208,182...78,286,106
Ensembl chr14:78,218,063...78,286,007

Loricrin

loricrin cornified envelope precursor protein

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of LOR mRNA

NCBI chr 2:177,558,062...177,559,980
Ensembl chr 2:177,558,252...177,559,807

Lrp4

LDL receptor related protein 4

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of LRP4 mRNA

NCBI chr 3:77,429,600...77,483,593
Ensembl chr 3:77,429,798...77,483,593

Lrrc17

leucine rich repeat containing 17

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of LRRC17 mRNA

NCBI chr 4:13,501,428...13,531,845
Ensembl chr 4:13,501,436...13,531,845

Lrrc41

leucine rich repeat containing 41

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of LRRC41 mRNA

NCBI chr 5:129,554,547...129,575,450
Ensembl chr 5:129,554,547...129,575,449

Lrrk2

leucine-rich repeat kinase 2

multiple interactions

[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of ACHE mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5R1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CDK5RAP1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of CHRM2 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of EFNB1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of FEZ1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEY2 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NDP mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NRG1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX6 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of POU3F3 mRNA; [LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA; LRRK2 protein mutant form inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA]
3-(4-(morpholin-4-yl)-7H-pyrrolo(2,3-d)pyrimidin-5-yl)benzonitrile inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of LRRK2 protein]; [Paraquat co-treated with Maneb] results in increased phosphorylation of LRRK2 protein; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of LRRK2 protein]; Plant Extracts inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of LRRK2 protein]

PMID:23017109 PMID:34897981

NCBI chr 7:122,826,712...122,987,711
Ensembl chr 7:122,826,696...122,987,703

Lynx1

Ly6/neurotoxin 1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of LYNX1 mRNA

NCBI chr 7:106,632,800...106,638,003
Ensembl chr 7:106,632,797...106,638,023

Macf1

microtubule-actin crosslinking factor 1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of MACF1 mRNA

NCBI chr 5:135,623,729...135,949,097
Ensembl chr 5:135,623,742...135,945,905

Map2

microtubule-associated protein 2

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2 mRNA]

NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809

Map2k1

mitogen activated protein kinase kinase 1

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAP2K1 mRNA]

NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147

Map2k6

mitogen-activated protein kinase kinase 6

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of MAP2K6 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of MAP2K6 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of MAP2K6 mRNA]

NCBI chr10:95,373,304...95,490,406
Ensembl chr10:95,373,204...95,488,293

Mapk1

mitogen activated protein kinase 1

multiple interactions

[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK1 protein
[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK1 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK1 protein]

PMID:15824117 PMID:30797899

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

Mapk15

mitogen-activated protein kinase 15

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of MAPK15 mRNA

NCBI chr 7:107,694,907...107,714,640
Ensembl chr 7:107,694,964...107,714,645

Mapk3

mitogen activated protein kinase 3

multiple interactions

[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK3 protein
[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK3 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of MAPK3 protein]

PMID:15824117 PMID:30797899

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

Mapt

microtubule-associated protein tau

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of MAPT mRNA]

NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129

Marchf9

membrane associated ring-CH-type finger 9

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of MARCHF9 mRNA

NCBI chr 7:62,879,017...62,882,495
Ensembl chr 7:62,879,018...62,882,495

Mbd3

methyl-CpG binding domain protein 3

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of MBD3 mRNA; [Paraquat co-treated with Maneb] results in increased expression of MBD3 mRNA

NCBI chr 7:9,312,961...9,320,166
Ensembl chr 7:9,313,098...9,320,165

Mbnl1

muscleblind-like splicing regulator 1

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of MBNL1 mRNA

NCBI chr 2:144,639,819...144,814,395
Ensembl chr 2:144,670,285...144,814,368

Mboat2

membrane bound O-acyltransferase domain containing 2

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of MBOAT2 mRNA

NCBI chr 6:41,471,135...41,597,599
Ensembl chr 6:41,471,161...41,593,485

Mcl1

MCL1 apoptosis regulator, BCL2 family member

increases expression
multiple interactions

Maneb results in increased expression of MCL1 protein
[Paraquat co-treated with Maneb] results in increased expression of MCL1 protein

NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303

Mdm4

MDM4 regulator of p53

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of MDM4 mRNA

NCBI chr13:44,432,596...44,516,165
Ensembl chr13:44,406,213...44,474,226

Mef2c

myocyte enhancer factor 2C

multiple interactions

[Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased metabolism of MEF2C protein; [Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased metabolism of MEF2C protein

PMID:24290359

NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880

Mfge8

milk fat globule EGF and factor V/VIII domain containing

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of MFGE8 mRNA

NCBI chr 1:133,064,665...133,080,069
Ensembl chr 1:133,064,665...133,080,073

Mrc1

mannose receptor, C type 1

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of MRC1 mRNA

PMID:29568078

NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857

Mrpl15

mitochondrial ribosomal protein L15

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of MRPL15 mRNA

NCBI chr 5:14,729,966...14,741,276
Ensembl chr 5:14,729,979...14,741,276

Mrtfb

myocardin related transcription factor B

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of MRTFB mRNA

NCBI chr10:1,116,315...1,278,106
Ensembl chr10:1,116,310...1,277,897

Mthfr

methylenetetrahydrofolate reductase

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of MTHFR mRNA

NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797

Mtor

mechanistic target of rapamycin kinase

multiple interactions
increases expression

[Paraquat co-treated with Maneb] results in increased expression of MTOR protein; Maneb promotes the reaction [Paraquat results in increased expression of MTOR protein]; Paraquat promotes the reaction [Maneb results in increased expression of MTOR protein]

PMID:22292029 PMID:26884967

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

Muc6

mucin 6, oligomeric mucus/gel-forming

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of MUC6 mRNA

NCBI chr 1:196,726,678...196,764,842
Ensembl chr 1:196,726,807...196,764,842

Myc

MYC proto-oncogene, bHLH transcription factor

multiple interactions

[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in increased expression of MYC protein

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

Ncf1

neutrophil cytosolic factor 1

multiple interactions

[Maneb co-treated with Paraquat] affects the localization of NCF1 protein; [Maneb co-treated with Paraquat] results in increased expression of NCF1 protein; [Paraquat co-treated with Maneb] results in increased expression of NCF1 protein; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NCF1 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NCF1 protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] affects the localization of NCF1 protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NCF1 protein]

PMID:28202386 PMID:29568078 PMID:32375810 PMID:34052309

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

Ndp

norrin cystine knot growth factor NDP

multiple interactions

[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NDP mRNA

NCBI chr X:5,796,487...5,820,934
Ensembl chr X:5,796,487...5,820,934

Neurod1

neuronal differentiation 1

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of NEUROD1 mRNA

NCBI chr 3:64,360,222...64,363,526
Ensembl chr 3:64,359,395...64,363,649

Nfat5

nuclear factor of activated T-cells 5

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of NFAT5 mRNA

NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675

Nfe2l2

NFE2 like bZIP transcription factor 2

increases expression
increases response to substance
multiple interactions

[Maneb results in increased expression of NFE2L2 protein] which results in increased expression of GCLC mRNA; [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of PRDX1 mRNA; [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of TXN1 mRNA; [Maneb results in increased expression of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA; Maneb results in increased expression of NFE2L2 protein
NFE2L2 gene mutant form results in increased susceptibility to Maneb
[NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased abundance of Glutathione; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased expression of GSR protein; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in decreased expression of HMOX1 protein; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in increased abundance of Manganese; [NFE2L2 gene mutant form results in increased susceptibility to Maneb] which results in increased abundance of Thiobarbituric Acid Reactive Substances; NFE2L2 gene mutant form inhibits the reaction [Maneb results in increased expression of GPX4 mRNA]

PMID:21402726 PMID:23764462

NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737

Nfib

nuclear factor I/B

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of NFIB mRNA

NCBI chr 5:96,759,208...96,973,092
Ensembl chr 5:96,764,653...96,975,479

Nfkb1

nuclear factor kappa B subunit 1

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of NFKB1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NFKB1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NFKB1 mRNA]

NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404

Nfkbia

NFKB inhibitor alpha

multiple interactions

[Maneb co-treated with Paraquat] results in increased phosphorylation of and results in decreased expression of NFKBIA protein; [Paraquat co-treated with Maneb] results in increased degradation of and results in increased phosphorylation of NFKBIA protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of and results in decreased expression of NFKBIA protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased degradation of and results in increased phosphorylation of NFKBIA protein]

PMID:28202386 PMID:29568078

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

Nipbl

NIPBL, cohesin loading factor

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of NIPBL mRNA

NCBI chr 2:57,399,443...57,586,770
Ensembl chr 2:57,399,445...57,565,899

Nlrp3

NLR family, pyrin domain containing 3

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of NLRP3 protein; [Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NLRP3 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of NLRP3 protein]

PMID:32375810 PMID:34052309

NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811

Nog

noggin

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of NOG mRNA

NCBI chr10:74,128,712...74,130,339
Ensembl chr10:74,128,712...74,130,339

Nos2

nitric oxide synthase 2

multiple interactions
increases expression

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; [Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA; [Maneb co-treated with Paraquat] results in increased expression of NOS2 protein; [Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA; [Paraquat co-treated with Maneb] results in increased expression of NOS2 protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Genistein inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 protein]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; prolinedithiocarbamate inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of NOS2 mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]
[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOS2 mRNA]; Silymarin inhibits the reaction [Maneb results in increased expression of NOS2 mRNA]

PMID:20455021 PMID:23159886 PMID:23963992 PMID:28202386 PMID:29568078 More...

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

Nox1

NADPH oxidase 1

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA]; diphenyleneiodonium inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of NOX1 mRNA]

PMID:30797899

NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236

Nps

neuropeptide S

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of NPS mRNA

NCBI chr 1:190,077,040...190,080,821
Ensembl chr 1:190,077,040...190,080,821

Nqo1

NAD(P)H quinone dehydrogenase 1

increases expression

[Maneb results in increased expression of NFE2L2 protein] which results in increased expression of NQO1 mRNA

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

Nr4a1

nuclear receptor subfamily 4, group A, member 1

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of NR4A1 mRNA

NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297

Nr4a2

nuclear receptor subfamily 4, group A, member 2

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of NR4A2 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of NR4A2 protein

PMID:29152652

NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877

Nrg1

neuregulin 1

multiple interactions

[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NRG1 mRNA

NCBI chr16:59,250,658...60,303,024
Ensembl chr16:59,250,854...60,296,884

Nrtn

neurturin

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of NRTN mRNA

NCBI chr 9:1,581,860...1,587,835
Ensembl chr 9:1,581,975...1,583,102

Ntn1

netrin 1

multiple interactions

[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA; [Maneb co-treated with Paraquat] results in decreased expression of NTN1 mRNA

NCBI chr10:52,899,933...53,098,591
Ensembl chr10:52,899,934...53,085,326

Ntrk2

neurotrophic receptor tyrosine kinase 2

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of NTRK2 mRNA]

NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136

Oaz2

ornithine decarboxylase antizyme 2

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of OAZ2 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of OAZ2 mRNA]

NCBI chr 8:66,199,694...66,213,513
Ensembl chr 8:66,199,706...66,231,453

P2ry4

pyrimidinergic receptor P2Y4

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of P2RY4 mRNA]

NCBI chr X:65,681,680...65,717,404
Ensembl chr X:65,683,232...65,721,748

Park7

Parkinsonism associated deglycase

multiple interactions

3-(4-(morpholin-4-yl)-7H-pyrrolo(2,3-d)pyrimidin-5-yl)benzonitrile inhibits the reaction [[Paraquat co-treated with Maneb] results in increased oxidation of PARK7 protein]; [Paraquat co-treated with Maneb] results in increased oxidation of PARK7 protein; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased oxidation of PARK7 protein]; Plant Extracts inhibits the reaction [[Paraquat co-treated with Maneb] results in increased oxidation of PARK7 protein]

PMID:34897981

NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970

Pax5

paired box 5

multiple interactions

[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX5 mRNA

NCBI chr 5:58,763,334...58,945,719
Ensembl chr 5:58,765,036...58,944,326

Pax6

paired box 6

multiple interactions

[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX6 mRNA

NCBI chr 3:92,128,772...92,157,022
Ensembl chr 3:92,135,637...92,157,014

Pcdh7

protocadherin 7

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of PCDH7 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PCDH7 mRNA]

NCBI chr14:52,471,801...52,901,696
Ensembl chr14:52,475,610...52,902,051
Ensembl chr14:52,475,610...52,902,051

Pcna

proliferating cell nuclear antigen

multiple interactions

3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of PCNA protein]; [Paraquat co-treated with Maneb] results in decreased expression of PCNA protein

PMID:23985028

NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995

Pcp2

Purkinje cell protein 2

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of PCP2 mRNA

NCBI chr12:1,681,659...1,683,899
Ensembl chr12:1,681,659...1,683,899

Pdcd10

programmed cell death 10

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of PDCD10 mRNA

NCBI chr 2:160,303,465...160,346,086
Ensembl chr 2:160,303,449...160,346,018

Pde1b

phosphodiesterase 1B

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of PDE1B mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PDE1B mRNA]

NCBI chr 7:134,627,378...134,654,581
Ensembl chr 7:134,627,322...134,654,580

Pdgfra

platelet derived growth factor receptor alpha

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA]

NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335

Pdha1

pyruvate dehydrogenase E1 subunit alpha 1

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of PDHA1 mRNA; [Maneb co-treated with Paraquat] results in increased expression of PDHA1 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PDHA1 protein]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PDHA1 mRNA]

PMID:23562983 PMID:23963992

NCBI chr X:34,700,481...34,714,309
Ensembl chr X:34,700,409...34,714,311

Pdyn

prodynorphin

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of PDYN

PMID:24376148

NCBI chr 3:116,900,990...116,913,334
Ensembl chr 3:116,900,992...116,913,334

Pebp1

phosphatidylethanolamine binding protein 1

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of PEBP1 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PEBP1 protein]

NCBI chr12:39,302,864...39,307,064
Ensembl chr12:39,302,840...39,307,862

Pgs1

phosphatidylglycerophosphate synthase 1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of PGS1 mRNA

NCBI chr10:103,214,635...103,250,254
Ensembl chr10:103,214,646...103,250,254

Pigc

phosphatidylinositol glycan anchor biosynthesis, class C

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of PIGC mRNA

NCBI chr13:74,343,619...74,346,148
Ensembl chr13:74,296,854...74,346,211

Plce1

phospholipase C, epsilon 1

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of PLCE1 mRNA

NCBI chr 1:236,243,445...236,552,571
Ensembl chr 1:236,244,683...236,551,438

Pmaip1

phorbol-12-myristate-13-acetate-induced protein 1

increases expression

Maneb results in increased expression of PMAIP1 mRNA; Maneb results in increased expression of PMAIP1 protein

NCBI chr18:59,986,187...59,990,174
Ensembl chr18:59,986,017...59,992,429

Pnoc

prepronociceptin

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of PNOC

PMID:24376148

NCBI chr15:39,624,635...39,652,463
Ensembl chr15:39,624,641...39,651,867

Polr1c

RNA polymerase I and III subunit C

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of POLR1C mRNA

NCBI chr 9:14,735,740...14,739,852
Ensembl chr 9:14,735,714...14,739,852

Polr2k

RNA polymerase II, I and III subunit K

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of POLR2K mRNA

NCBI chr 7:67,347,118...67,359,466
Ensembl chr 7:67,356,113...67,357,668

Pou3f3

POU class 3 homeobox 3

multiple interactions

[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of POU3F3 mRNA

NCBI chr 9:44,945,872...44,948,986
Ensembl chr 9:44,945,872...44,948,992

Prdx1

peroxiredoxin 1

increases expression

[Maneb results in increased expression of NFE2L2 protein] which results in increased expression of PRDX1 mRNA

NCBI chr 5:130,147,276...130,162,850
Ensembl chr 5:130,147,204...130,162,856

Prdx3

peroxiredoxin 3

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PRDX3 protein]

NCBI chr 1:260,001,642...260,014,064
Ensembl chr 1:260,001,637...260,014,111

Prkaca

protein kinase cAMP-activated catalytic subunit alpha

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of PRKACA mRNA; [Paraquat co-treated with Maneb] results in decreased expression of PRKACA protein; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of PRKACA mRNA]

PMID:27460631 PMID:33368748

NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430

Prkcz

protein kinase C, zeta

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of PRKCZ mRNA

NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367

Prkn

parkin RBR E3 ubiquitin protein ligase

multiple interactions

3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased nitrosation of PRKN protein]; [Paraquat co-treated with Maneb] results in increased expression of PRKN protein; [Paraquat co-treated with Maneb] results in increased nitrosation of PRKN protein

PMID:22563483 PMID:23985028

NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555

Prl

prolactin

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of PRL mRNA

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

Prr7

proline rich 7 (synaptic)

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of PRR7 mRNA

NCBI chr17:9,164,375...9,173,669
Ensembl chr17:9,165,269...9,172,536

Psap

prosaposin

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of PSAP mRNA

NCBI chr20:28,214,229...28,240,501
Ensembl chr20:28,214,271...28,240,498

Psen1

presenilin 1

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of PSEN1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PSEN1 mRNA]

NCBI chr 6:103,323,014...103,375,088
Ensembl chr 6:103,323,120...103,371,650

Psmb1

proteasome 20S subunit beta 1

multiple interactions

Maneb inhibits the reaction [Paraquat results in decreased expression of PSMB1 mRNA]

PMID:26498265

NCBI chr 1:56,442,432...56,463,544
Ensembl chr 1:56,420,618...56,463,560

Psmc4

proteasome 26S subunit, ATPase 4

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of PSMC4 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of PSMC4 mRNA]
[Paraquat co-treated with Maneb] results in decreased expression of PSMC4 mRNA

PMID:23963992 PMID:26498265

NCBI chr 1:83,349,127...83,357,497
Ensembl chr 1:83,348,592...83,357,494

Ptk2b

protein tyrosine kinase 2 beta

multiple interactions

[alachlor co-treated with Captan co-treated with Diazinon co-treated with Endosulfan co-treated with mancozeb co-treated with Maneb] results in decreased expression of PTK2B protein modified form

NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282

Ptpn4

protein tyrosine phosphatase, non-receptor type 4

affects activity

Maneb affects the activity of PTPN4 protein

PMID:23611293

NCBI chr13:30,772,012...30,952,340
Ensembl chr13:30,776,682...30,952,170

Ptpn9

protein tyrosine phosphatase, non-receptor type 9

affects activity

Maneb affects the activity of PTPN9 protein

PMID:23611293

NCBI chr 8:57,391,290...57,472,352
Ensembl chr 8:57,391,259...57,470,952

Raf1

Raf-1 proto-oncogene, serine/threonine kinase

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of RAF1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RAF1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RAF1 mRNA]

NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317

Rb1

RB transcriptional corepressor 1

multiple interactions
increases expression

[Maneb co-treated with Paraquat] results in increased expression of RB1 mRNA; Acetylcysteine inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of RB1 mRNA]; Acetylcysteine inhibits the reaction [Maneb results in increased expression of RB1 mRNA]

PMID:29859004

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

Rbx1

ring-box 1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of RBX1 mRNA

NCBI chr 7:112,976,863...113,001,051
Ensembl chr 7:112,990,835...113,001,051

Rela

RELA proto-oncogene, NF-kB subunit

multiple interactions

[Maneb co-treated with Paraquat] results in increased phosphorylation of RELA protein; [Paraquat co-treated with Maneb] results in increased phosphorylation of RELA protein; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of RELA protein]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased phosphorylation of RELA protein]

PMID:28202386 PMID:29568078

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

Ripk1

receptor interacting serine/threonine kinase 1

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of RIPK1 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of RIPK1 mRNA]

NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824

Rock1

Rho-associated coiled-coil containing protein kinase 1

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of ROCK1 mRNA

NCBI chr18:1,114,532...1,236,345
Ensembl chr18:1,115,905...1,235,571

Rpl12

ribosomal protein L12

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of RPL12 mRNA

NCBI chr 3:16,264,269...16,266,645
Ensembl chr 3:16,264,251...16,266,642

Rpl19

ribosomal protein L19

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of RPL19 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of RPL19 mRNA]

NCBI chr10:83,022,503...83,026,030
Ensembl chr10:83,019,257...83,052,112

Rpl41

ribosomal protein L41

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of RPL41 mRNA

NCBI chr 7:977,885...978,965

Rpl8

ribosomal protein L8

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of RPL8 mRNA

NCBI chr 7:108,626,194...108,628,485
Ensembl chr 7:108,622,324...108,628,482

Rpl9

ribosomal protein L9

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of RPL9 mRNA

NCBI chr14:42,893,945...42,897,140
Ensembl chr14:42,893,942...42,897,136

Rps12

ribosomal protein S12

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of RPS12 mRNA

NCBI chr 1:21,680,854...21,683,010
Ensembl chr 1:21,680,852...21,683,014

Rps15

ribosomal protein S15

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of RPS15 mRNA

NCBI chr 7:9,416,003...9,417,442
Ensembl chr 7:9,416,004...9,417,450

Rps27

ribosomal protein S27

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of RPS27 mRNA

NCBI chr 2:175,665,858...175,666,963
Ensembl chr 2:175,665,853...175,666,964

Rps6ka2

ribosomal protein S6 kinase A2

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of RPS6KA2 mRNA

NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739

Rtn4

reticulon 4

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of RTN4 mRNA

NCBI chr14:103,450,074...103,497,687
Ensembl chr14:103,449,930...103,497,686

Rtn4rl2

reticulon 4 receptor-like 2

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of RTN4RL2 mRNA

NCBI chr 3:69,954,557...69,971,108
Ensembl chr 3:69,955,169...69,971,488

S100a8

S100 calcium binding protein A8

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of S100A8 mRNA

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

S100a9

S100 calcium binding protein A9

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of S100A9 mRNA

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

Scamp2

secretory carrier membrane protein 2

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of SCAMP2 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SCAMP2 mRNA]

NCBI chr 8:57,965,612...57,992,248
Ensembl chr 8:57,965,631...57,992,646

Scand1

SCAN domain-containing 1

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of SCAND1 mRNA

NCBI chr 3:144,818,615...144,819,479
Ensembl chr 3:144,818,611...144,820,025

Sdhb

succinate dehydrogenase complex iron sulfur subunit B

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of SDHB mRNA

NCBI chr 5:153,264,906...153,285,570
Ensembl chr 5:153,264,899...153,314,293

Sema4d

semaphorin 4D

multiple interactions

[SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of SEMA4D mRNA

NCBI chr17:13,430,324...13,537,146
Ensembl chr17:13,430,379...13,537,138

Sirt1

sirtuin 1

decreases activity

Maneb results in decreased activity of SIRT1 protein

NCBI chr20:25,307,143...25,329,260
Ensembl chr20:25,306,917...25,329,260

Sirt2

sirtuin 2

decreases activity

Maneb results in decreased activity of SIRT2 protein

NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975

Sirt3

sirtuin 3

decreases activity

Maneb results in decreased activity of SIRT3 protein

NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808

Slc17a8

solute carrier family 17 member 8

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of SLC17A8 mRNA

NCBI chr 7:23,994,212...24,049,498
Ensembl chr 7:23,994,217...24,048,079

Slc18a2

solute carrier family 18 member A2

multiple interactions
decreases expression

[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA; Ketoconazole inhibits the reaction [Maneb results in decreased expression of SLC18A2 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC18A2 mRNA]

PMID:18386188 PMID:20964710 PMID:22334051

NCBI chr 1:258,413,748...258,449,143
Ensembl chr 1:258,413,959...258,448,325

Slc22a2

solute carrier family 22 member 2

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of SLC22A2 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SLC22A2 mRNA]

NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268

Slc40a1

solute carrier family 40 member 1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of SLC40A1 protein; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of SLC40A1 protein]

PMID:30797899

NCBI chr 9:48,033,526...48,053,876
Ensembl chr 9:48,033,526...48,051,481

Slc5a7

solute carrier family 5 member 7

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of SLC5A7 mRNA

NCBI chr 9:7,595,440...7,626,258
Ensembl chr 9:7,595,444...7,626,258

Slc6a2

solute carrier family 6 member 2

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of SLC6A2 mRNA

NCBI chr19:14,010,292...14,055,317
Ensembl chr19:14,010,386...14,050,357

Slc6a3

solute carrier family 6 member 3

multiple interactions
affects response to substance

[Paraquat co-treated with Maneb] results in decreased expression of SLC6A3 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of SLC6A3 protein
SLC6A3 gene polymorphism affects the susceptibility to Maneb

PMID:11124998 PMID:18386188 PMID:19590691

NCBI chr 1:29,709,443...29,750,413
Ensembl chr 1:29,709,443...29,750,413

Slc8a1

solute carrier family 8 member A1

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of SLC8A1 mRNA

NCBI chr 6:13,194,609...13,547,369
Ensembl chr 6:13,194,662...13,535,628

Snca

synuclein alpha

multiple interactions
increases response to substance

[Maneb co-treated with Paraquat] results in increased phosphorylation of SNCA protein; [Paraquat co-treated with Maneb] promotes the reaction [SNCA protein binds to SNCA protein]; [Paraquat co-treated with Maneb] results in increased expression of SNCA protein; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ADORA1 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of APBB1 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of ASCL1 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP2 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of BMP4 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DLL1 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD2 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of DRD5 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of HEYL mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of PAX5 mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of SEMA4D mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of SNCA protein]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] promotes the reaction [SNCA protein binds to SNCA protein]]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of SNCA protein]; SNCA protein inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of CDK5RAP2 mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] promotes the reaction [SNCA protein binds to SNCA protein]]
SNCA gene mutant form results in increased susceptibility to Maneb
[Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased abundance of Nitric Oxide; [Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]] which results in increased metabolism of MEF2C protein; [Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased abundance of Nitric Oxide; [Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]] which results in increased metabolism of MEF2C protein; Maneb promotes the reaction [Paraquat results in increased expression of SNCA protein]; Maneb promotes the reaction [SNCA gene mutant form results in increased susceptibility to Paraquat]; Paraquat promotes the reaction [SNCA gene mutant form results in increased susceptibility to Maneb]; SNCA protein mutant form results in increased susceptibility to [Paraquat co-treated with Maneb]; SNCA protein results in increased susceptibility to [Maneb co-treated with Paraquat]

PMID:23017109 PMID:24290359 PMID:26498265 PMID:27324791 PMID:29568078 More...

NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262

Sod1

superoxide dismutase 1

multiple interactions

SOD1 protein results in decreased susceptibility to [Paraquat co-treated with Maneb]
[Maneb co-treated with Paraquat] results in increased expression of SOD1 mRNA
[Paraquat co-treated with Maneb] results in decreased expression of SOD1 mRNA

PMID:15824117 PMID:18386188 PMID:29859004

NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249

Sod2

superoxide dismutase 2

multiple interactions
decreases expression

[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SOD2 protein]
Maneb results in decreased expression of SOD2 mRNA

PMID:23562983 PMID:26210702

NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189

Stat3

signal transducer and activator of transcription 3

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of STAT3 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT3 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT3 mRNA]

NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057

Stat4

signal transducer and activator of transcription 4

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STAT4 mRNA]

NCBI chr 9:49,472,660...49,588,540
Ensembl chr 9:49,419,340...49,588,540

Stmn1

stathmin 1

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of STMN1 protein]

NCBI chr 5:146,680,757...146,687,154
Ensembl chr 5:146,681,436...146,687,154

Ston2

stonin 2

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of STON2 mRNA

NCBI chr 6:110,567,485...110,676,376
Ensembl chr 6:110,567,485...110,676,376

Strbp

spermatid perinuclear RNA binding protein

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of STRBP mRNA

NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949

Sumo1

small ubiquitin-like modifier 1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of SUMO1 mRNA

NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761

Syt5

synaptotagmin 5

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of SYT5 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SYT5 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of SYT5 mRNA]

NCBI chr 1:69,277,351...69,285,071
Ensembl chr 1:69,277,351...69,285,067

Tbck

TBC1 domain containing kinase

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of TBCK mRNA

NCBI chr 2:221,175,749...221,348,126
Ensembl chr 2:221,175,785...221,348,126

Tecr

trans-2,3-enoyl-CoA reductase

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of TECR mRNA

NCBI chr19:24,526,705...24,568,168
Ensembl chr19:24,541,615...24,568,168

Tgfb1

transforming growth factor, beta 1

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of TGFB1 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TGFB1 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TGFB1 mRNA]

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

tyrosine hydroxylase

multiple interactions
decreases expression

4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]; [Paraquat co-treated with Maneb] results in decreased expression of TH protein; [Paraquat co-treated with Maneb] results in increased expression of TH protein; Genistein inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]; Ketoconazole inhibits the reaction [Maneb results in decreased expression of TH protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]; pimagedine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]; prolinedithiocarbamate inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TH protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TH protein]
[Paraquat co-treated with Maneb] results in decreased expression of TH; [Paraquat co-treated with Maneb] results in decreased expression of TH mRNA; [Paraquat co-treated with Maneb] results in decreased expression of TH protein

PMID:11124998 PMID:18386188 PMID:20455021 PMID:20964710 PMID:22334051 More...

NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767

Timm13

translocase of inner mitochondrial membrane 13

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of TIMM13 mRNA

NCBI chr 7:8,809,069...8,810,172
Ensembl chr 7:8,809,058...8,809,910

Tmem42

transmembrane protein 42

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of TMEM42 mRNA

NCBI chr 8:122,674,793...122,677,290
Ensembl chr 8:122,674,070...122,677,276

Tnf

tumor necrosis factor

increases expression
multiple interactions

Maneb results in increased expression of TNF mRNA
[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA; [Paraquat co-treated with Maneb] results in increased expression of TNF mRNA; acetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; acetovanillone inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Glyburide inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; ITGAM protein affects the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Poloxamer inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNF mRNA]; Taurine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]
[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA; Acetylcysteine inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TNF mRNA]; Silymarin inhibits the reaction [Maneb results in increased expression of TNF mRNA]

PMID:23159886 PMID:23963992 PMID:28202386 PMID:29568078 PMID:30797899 More...

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Tnfaip3

TNF alpha induced protein 3

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TNFAIP3 mRNA]

NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282

Tnr

tenascin R

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of TNR mRNA

NCBI chr13:71,751,714...72,172,731
Ensembl chr13:72,091,585...72,167,641

Tp53

tumor protein p53

multiple interactions

3-bromo-7-nitroindazole inhibits the reaction [[Paraquat co-treated with Maneb] results in increased expression of TRP53 protein]; [Maneb co-treated with Paraquat] results in increased expression of TRP53 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of TRP53 protein; [Paraquat co-treated with Maneb] results in increased activity of TRP53 protein modified form; [Paraquat co-treated with Maneb] results in increased expression of TRP53 protein; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRP53 mRNA]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TRP53 protein]; Melatonin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of TRP53 protein modified form]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRP53 mRNA]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in decreased expression of TRP53 protein]; Silymarin inhibits the reaction [[Paraquat co-treated with Maneb] results in increased activity of TRP53 protein modified form]

PMID:20964710 PMID:23963992 PMID:23985028

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

Traf3ip2

Traf3 interacting protein 2

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of ACT1 protein

NCBI chr20:43,011,405...43,054,654
Ensembl chr20:43,011,450...43,054,667

Traf6

TNF receptor associated factor 6

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TRAF6 mRNA]

NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507

Trpm3

transient receptor potential cation channel, subfamily M, member 3

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of TRPM3 mRNA

NCBI chr 1:219,673,200...220,557,610
Ensembl chr 1:219,672,892...220,560,717

Tuba1a

tubulin, alpha 1A

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein]; Minocycline inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of TUBA1A protein]

NCBI chr 7:130,113,214...130,116,880
Ensembl chr 7:130,081,032...130,196,186

Tuba1b

tubulin, alpha 1B

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of TUBA1B mRNA

NCBI chr 7:130,090,669...130,093,644
Ensembl chr 7:130,081,032...130,196,186

Tubb5

tubulin, beta 5 class I

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of TUBB5 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of TUBB5 mRNA]

NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940

Tusc1

tumor suppressor candidate 1

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of TUSC1 mRNA

NCBI chr 5:108,089,952...108,091,636
Ensembl chr 5:108,090,613...108,091,224

Txn1

thioredoxin 1

increases expression

[Maneb results in increased expression of NFE2L2 protein] which results in increased expression of TXN1 mRNA

NCBI chr 5:72,712,334...72,724,564
Ensembl chr 5:72,711,933...72,724,629

Txnrd1

thioredoxin reductase 1

increases expression

[Maneb results in increased expression of NFE2L2 protein] which results in increased expression of TXNRD1 mRNA

NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863

Uba1

ubiquitin-like modifier activating enzyme 1

multiple interactions

Maneb results in decreased activity of and results in decreased ubiquitination of UBA1 protein

PMID:25714994

NCBI chr X:1,508,700...1,530,677
Ensembl chr X:1,508,666...1,530,636

Ubb

ubiquitin B

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of UBB mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of UBB mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of UBB mRNA]

NCBI chr10:47,247,629...47,249,335
Ensembl chr10:47,245,637...47,249,333

Ubc

ubiquitin C

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of UBC mRNA

NCBI chr12:31,238,889...31,243,924
Ensembl chr12:31,239,152...31,243,925

Ubxn7

UBX domain protein 7

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of UBXN7 mRNA

NCBI chr11:68,427,896...68,460,100

Uchl1

ubiquitin C-terminal hydrolase L1

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of UCHL1 protein; [Paraquat co-treated with Maneb] results in decreased expression of UCHL1 mRNA

PMID:18386188 PMID:23562983

NCBI chr14:41,485,033...41,495,590
Ensembl chr14:41,485,031...41,495,590

Uchl5

ubiquitin C-terminal hydrolase L5

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of UCHL5 mRNA

NCBI chr13:55,520,722...55,556,503
Ensembl chr13:55,520,729...55,556,502

Unc13c

unc-13 homolog C

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of UNC13C mRNA

NCBI chr 8:74,247,026...74,697,629
Ensembl chr 8:74,247,899...74,673,223

Upf3b

UPF3B, regulator of nonsense mediated mRNA decay

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of UPF3B mRNA

NCBI chr X:116,335,308...116,353,332
Ensembl chr X:116,335,308...116,353,236

Uqcrc1

ubiquinol-cytochrome c reductase core protein 1

multiple interactions

[Maneb co-treated with Paraquat] results in increased expression of UQCRC1 protein; Levodopa inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of UQCRC1 protein]; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of UQCRC1 protein]

NCBI chr 8:109,589,735...109,601,481
Ensembl chr 8:109,589,706...109,601,480

Vamp5

vesicle-associated membrane protein 5

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of VAMP5 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VAMP5 mRNA]; Silymarin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VAMP5 mRNA]

NCBI chr 4:104,423,813...104,435,059
Ensembl chr 4:104,423,820...104,426,212

Vegfa

vascular endothelial growth factor A

multiple interactions

[LRRK2 protein mutant form co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA; [SNCA protein co-treated with Maneb co-treated with Paraquat] results in decreased expression of VEGFA mRNA

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

Vps45

vacuolar protein sorting 45 homolog

multiple interactions

[Maneb co-treated with Paraquat] results in decreased expression of VPS45 mRNA; Melatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in decreased expression of VPS45 mRNA]

NCBI chr 2:183,555,919...183,616,312
Ensembl chr 2:183,555,921...183,616,295

Wnt1

Wnt family member 1

multiple interactions

[Paraquat co-treated with Maneb] results in decreased expression of WNT1 mRNA; [Paraquat co-treated with Maneb] results in decreased expression of WNT1 protein

PMID:29152652

NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651

Wnt5a

Wnt family member 5A

multiple interactions

[Paraquat co-treated with Maneb] results in increased expression of WNT5A mRNA; [Paraquat co-treated with Maneb] results in increased expression of WNT5A protein

PMID:29152652

NCBI chr16:3,695,667...3,718,234
Ensembl chr16:3,697,032...3,718,234

Zbtb44

zinc finger and BTB domain containing 44

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of ZBTB44 mRNA

NCBI chr 8:29,466,055...29,524,027
Ensembl chr 8:29,466,352...29,518,163

Zfp580

zinc finger protein 580

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of ZFP580 mRNA

NCBI chr 1:68,787,118...68,789,286
Ensembl chr 1:68,787,118...68,789,286

Zhx3

zinc fingers and homeoboxes 3

multiple interactions

[Paraquat co-treated with Maneb] affects the expression of ZHX3 mRNA

NCBI chr 3:149,417,843...149,548,671
Ensembl chr 3:149,417,818...149,527,079

manganese atom

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

Abca5

ATP binding cassette subfamily A member 5

decreases expression

Manganese results in decreased expression of ABCA5 mRNA

NCBI chr10:95,240,159...95,309,195
Ensembl chr10:95,240,154...95,308,976

Abca9

ATP binding cassette subfamily A member 9

increases expression

Manganese results in increased expression of ABCA9 mRNA

NCBI chr10:95,077,615...95,137,751
Ensembl chr10:95,079,058...95,139,608

Abcb1a

ATP binding cassette subfamily B member 1A

increases activity
increases expression
multiple interactions

Manganese results in increased activity of ABCB1 protein
Manganese results in increased expression of ABCB1A mRNA
[Manganese results in increased activity of ABCB1 protein] which results in increased hydrolysis of Adenosine Triphosphate

PMID:2900677 PMID:26745496

NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709

Abcc6

ATP binding cassette subfamily C member 6

multiple interactions

Manganese promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]; Manganese promotes the reaction [beryllium fluoride promotes the reaction [8-azidoadenosine 5'-triphosphate binds to ABCC6 protein]]

PMID:12069597

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

Abcc8

ATP binding cassette subfamily C member 8

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased expression of ABCC8 protein

PMID:32659473

NCBI chr 1:96,598,663...96,679,495
Ensembl chr 1:96,598,647...96,679,510

Abi2

abl-interactor 2

increases expression

Manganese results in increased expression of ABI2 mRNA

NCBI chr 9:61,856,379...61,904,029
Ensembl chr 9:61,827,139...61,905,699

Acat2

acetyl-CoA acetyltransferase 2

decreases expression

Manganese results in decreased expression of ACAT2 mRNA

PMID:23499988

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

Ache

acetylcholinesterase

multiple interactions
increases activity

[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased activity of ACHE protein]; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein]; Taurine inhibits the reaction [Manganese results in increased activity of ACHE protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased activity of ACHE protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of ACHE mRNA alternative form

PMID:24885898 PMID:30738988 PMID:30844427 PMID:32445656 PMID:33314588

NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651

Aco1

aconitase 1

decreases activity
increases activity
multiple interactions

Manganese results in decreased activity of ACO1 protein
Manganese results in increased activity of ACO1 protein
Manganese results in increased stability of [ACO1 protein binds to SLC11A2 mRNA]

PMID:16386771 PMID:16545456 PMID:16568477 PMID:16729984 PMID:17469137

NCBI chr 5:55,259,841...55,315,872
Ensembl chr 5:55,259,827...55,316,391

Aco2

aconitase 2

multiple interactions
decreases activity
decreases expression

ferric ammonium citrate inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
Iron inhibits the reaction [Manganese results in decreased activity of ACO2 protein]
Manganese results in decreased expression of ACO2 mRNA; Manganese results in decreased expression of ACO2 protein

PMID:9675333 PMID:16625280 PMID:17469137

NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261

Acta1

actin, alpha 1, skeletal muscle

decreases expression

Manganese results in decreased expression of ACTA1 mRNA

NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742

Actr3

actin related protein 3

affects expression

Manganese affects the expression of ACTR3 protein

NCBI chr13:36,800,739...36,843,837
Ensembl chr13:36,800,093...36,844,124

Adgre1

adhesion G protein-coupled receptor E1

increases expression

Manganese results in increased expression of ADGRE1 mRNA

PMID:20224926

NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000

Adm

adrenomedullin

increases expression

Manganese results in increased expression of ADM mRNA

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

Afp

alpha-fetoprotein

decreases expression

Manganese results in decreased expression of AFP mRNA

NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480

Akap7

A-kinase anchoring protein 7

decreases expression

Manganese results in decreased expression of AKAP7 mRNA

NCBI chr 1:20,087,190...20,217,799
Ensembl chr 1:20,087,373...20,217,797

Akt1

AKT serine/threonine kinase 1

decreases expression
multiple interactions
increases phosphorylation

Manganese results in decreased expression of AKT1 protein
NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of AKT1 protein]
Manganese results in increased phosphorylation of AKT1 protein

PMID:17043766 PMID:24845367 PMID:31676349

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

Angpt2

angiopoietin 2

decreases expression

Manganese results in decreased expression of ANGPT2 mRNA

NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804

Angptl4

angiopoietin-like 4

increases expression

Manganese results in increased expression of ANGPTL4 mRNA

NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519

Anp32a

acidic nuclear phosphoprotein 32 family member A

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of ANP32A mRNA

NCBI chr 8:62,829,125...62,864,469
Ensembl chr 8:62,827,456...62,865,443

Ap3b2

adaptor related protein complex 3 subunit beta 2

increases expression

Manganese results in increased expression of AP3B2 mRNA

NCBI chr 1:135,412,580...135,445,191
Ensembl chr 1:135,412,580...135,445,191

Apol2

apolipoprotein L, 2

increases expression

Manganese results in increased expression of APOL2 mRNA

NCBI chr 7:109,331,367...109,338,632
Ensembl chr 7:109,331,392...109,338,558

App

amyloid beta precursor protein

increases expression

Manganese results in increased expression of APP mRNA

PMID:18583042

NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561

Aqp4

aquaporin 4

multiple interactions

Antioxidants inhibits the reaction [Manganese results in increased expression of AQP4 protein]

PMID:20648640

NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856

Arg1

arginase 1

affects binding
multiple interactions

Manganese binds to ARG1 protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of ARG1 mRNA

PMID:15248756 PMID:18802628 PMID:34018660

NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422

Arhgdia

Rho GDP dissociation inhibitor alpha

decreases expression

Manganese results in decreased expression of ARHGDIA mRNA

NCBI chr10:105,854,526...105,858,020
Ensembl chr10:105,854,533...105,858,023

Arhgef4

Rho guanine nucleotide exchange factor 4

increases expression

Manganese results in increased expression of ARHGEF4 mRNA

NCBI chr 9:36,861,800...37,005,079
Ensembl chr 9:36,861,835...37,005,075

Atf1

activating transcription factor 1

increases phosphorylation
multiple interactions

Manganese results in increased phosphorylation of ATF1 protein
SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of ATF1 protein]

PMID:16787641

NCBI chr 7:131,361,962...131,404,677
Ensembl chr 7:131,362,450...131,404,670

Atf6

activating transcription factor 6

decreases expression

Manganese results in decreased expression of ATF6 mRNA

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

Atm

ATM serine/threonine kinase

decreases expression

Manganese results in decreased expression of ATM mRNA

NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437

Atoh8

atonal bHLH transcription factor 8

decreases expression

Manganese results in decreased expression of ATOH8 mRNA

NCBI chr 4:104,259,992...104,292,168
Ensembl chr 4:104,259,992...104,292,168

Atp13a2

ATPase cation transporting 13A2

affects response to substance
decreases response to substance

ATP13A2 gene polymorphism affects the susceptibility to Manganese
ATP13A2 protein results in decreased susceptibility to Manganese

PMID:22285144 PMID:22847264

NCBI chr 5:153,292,722...153,312,143
Ensembl chr 5:153,292,751...153,312,139

Atp1a3

ATPase Na+/K+ transporting subunit alpha 3

decreases expression
increases methylation

Manganese results in decreased expression of ATP1A3 mRNA
Manganese results in increased methylation of ATP1A3 promoter

PMID:23976782

NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918

Atp7a

ATPase copper transporting alpha

affects localization
decreases expression

Manganese affects the localization of ATP7A protein
Manganese results in decreased expression of ATP7A mRNA; Manganese results in decreased expression of ATP7A protein

PMID:24614235

NCBI chr X:71,094,144...71,201,550
Ensembl chr X:71,094,202...71,198,354

Atp7b

ATPase copper transporting beta

increases phosphorylation
decreases expression
affects localization

Manganese results in increased phosphorylation of ATP7B protein
Manganese results in decreased expression of ATP7B mRNA; Manganese results in decreased expression of ATP7B protein
Manganese affects the localization of ATP7B protein

PMID:19405516 PMID:24614235

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

Atp8a1

ATPase phospholipid transporting 8A1

decreases expression

Manganese results in decreased expression of ATP8A1 mRNA

NCBI chr14:40,315,013...40,557,572
Ensembl chr14:40,315,049...40,554,611

Bace1

beta-secretase 1

increases expression

Manganese results in increased expression of BACE1 mRNA

PMID:18583042

NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876

Bax

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of BAX protein]; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; [Manganese co-treated with NGF protein] results in increased expression of BAX protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in increased expression of BAX protein]; Rolipram inhibits the reaction [Manganese results in increased expression of BAX protein]
NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]
[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BAX protein]

PMID:25027559 PMID:25791630 PMID:30844427 PMID:30951808 PMID:31161640 More...

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

Bcl2

BCL2, apoptosis regulator

multiple interactions
decreases expression

[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased expression of BCL2 protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of BCL2 protein]; Rolipram inhibits the reaction [Manganese results in decreased expression of BCL2 protein]

PMID:30844427 PMID:30951808 PMID:31161640 PMID:31676349 PMID:33314588

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

Bcl2l1

Bcl2-like 1

decreases expression
multiple interactions

Manganese results in decreased expression of BCL2L1 protein
[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein; PPM1D protein inhibits the reaction [[Manganese co-treated with NGF protein] results in decreased expression of BCL2L1 protein]

PMID:25791630

NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479

Bdnf

brain-derived neurotrophic factor

multiple interactions
decreases expression

[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of BDNF mRNA]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of BDNF protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]; Rolipram inhibits the reaction [Manganese results in decreased expression of BDNF protein]
Manganese results in decreased expression of BDNF mRNA; Manganese results in decreased expression of BDNF protein

PMID:17827730 PMID:25099302 PMID:29205667 PMID:30951808 PMID:31161640 More...

NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615

Bnip3

BCL2 interacting protein 3

multiple interactions

Antioxidants inhibits the reaction [Manganese results in increased expression of BNIP3 protein]

PMID:19442826

NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359

Bub1

BUB1 mitotic checkpoint serine/threonine kinase

decreases expression

Manganese results in decreased expression of BUB1 mRNA

NCBI chr 3:115,020,254...115,051,650
Ensembl chr 3:115,020,254...115,051,650

Calcoco2

calcium binding and coiled-coil domain 2

increases expression

Manganese results in increased expression of CALCOCO2 mRNA

NCBI chr10:81,055,467...81,069,298

Calr

calreticulin

affects expression

Manganese affects the expression of CALR protein

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

Camk2a

calcium/calmodulin-dependent protein kinase II alpha

decreases phosphorylation

Manganese results in decreased phosphorylation of CAMK2A protein

PMID:26616912

NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994

Capn1

calpain 1

increases activity
multiple interactions

Manganese results in increased activity of CAPN1 protein
calpain inhibitor III inhibits the reaction [Manganese results in increased activity of CAPN1 protein]

PMID:21985864

NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177

Car8

carbonic anhydrase 8

increases expression

Manganese results in increased expression of CAR8 mRNA

NCBI chr 5:21,302,940...21,402,395
Ensembl chr 5:21,305,383...21,402,374

Casp3

caspase 3

multiple interactions
increases activity
increases expression
increases cleavage

[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in increased expression of CASP3 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein; aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Manganese results in increased activity of CASP3 protein]; Deferoxamine inhibits the reaction [Manganese results in increased activity of CASP3 protein]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of CASP3 protein]; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; Manganese promotes the reaction [SP1 protein modified form binds to CASP3 promoter]; Manganese results in increased expression of and results in increased cleavage of CASP3 protein; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [Manganese results in increased expression of CASP3 protein]; quinoline-val-asp(OMe)-CH2-OPH inhibits the reaction [Manganese results in increased activity of CASP3 protein]; rhodioloside inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of CASP3 protein]; U 0126 inhibits the reaction [Manganese results in increased expression of CASP3 mRNA]; U 0126 inhibits the reaction [Manganese results in increased expression of CASP3 protein]
SNCA protein inhibits the reaction [Manganese results in increased activity of CASP3 protein]
Manganese results in increased expression of CASP3 mRNA; Manganese results in increased expression of CASP3 protein

PMID:11933051 PMID:16787641 PMID:21985864 PMID:22427945 PMID:22841634 More...

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

Casp7

caspase 7

increases activity

Manganese results in increased activity of CASP7 protein

PMID:22427945

NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729

Casp8

caspase 8

multiple interactions
increases activity

Rolipram inhibits the reaction [Manganese results in increased activity of CASP8 protein]

PMID:31161640

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

Casp9

caspase 9

increases cleavage
increases activity
multiple interactions

Manganese results in increased cleavage of CASP9 protein
Manganese results in increased activity of CASP9 protein
SNCA protein inhibits the reaction [Manganese results in increased activity of CASP9 protein]

PMID:16787641 PMID:25416158

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

Cat

catalase

multiple interactions
decreases activity

[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; CAT protein inhibits the reaction [[[PRNP protein binds to Manganese] which co-treated with Hydrogen Peroxide] results in increased cleavage of [PRNP protein binds to PRNP protein]]
Manganese results in decreased activity of CAT protein
[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of CAT protein; [manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased activity of CAT protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein; CAT protein inhibits the reaction [Manganese results in increased expression of SLC12A2 protein]; CAT protein inhibits the reaction [Manganese results in increased phosphorylation of and results in increased activity of SLC12A2 protein]; Ethanol promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CAT protein]; Silymarin inhibits the reaction [Manganese results in decreased activity of CAT protein]

PMID:16595185 PMID:17176674 PMID:23339144 PMID:25817889 PMID:30844427 More...

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

Cav1

caveolin 1

decreases expression

Manganese results in decreased expression of CAV1 mRNA; Manganese results in decreased expression of CAV1 protein

PMID:23499988 PMID:23597857

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

Cav3

caveolin 3

decreases expression

Manganese results in decreased expression of CAV3 mRNA; Manganese results in decreased expression of CAV3 protein

PMID:23597857

NCBI chr 4:145,582,168...145,598,142
Ensembl chr 4:145,582,060...145,598,137

Ccl2

C-C motif chemokine ligand 2

increases expression

Manganese results in increased expression of CCL2 mRNA

PMID:19782702

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

Ccl7

C-C motif chemokine ligand 7

increases expression

Manganese results in increased expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

Ccna1

cyclin A1

increases expression

Manganese results in increased expression of CCNA1 mRNA

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

Ccnb1

cyclin B1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB1 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB1 protein

PMID:34822792

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

Ccnb2

cyclin B2

decreases expression
multiple interactions

Manganese results in decreased expression of CCNB2 mRNA
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 mRNA; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 protein; YTHDC2 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 mRNA]; YTHDC2 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CCNB2 protein]

PMID:17175027 PMID:34822792

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

Ccnd1

cyclin D1

increases expression

Manganese results in increased expression of CCND1 mRNA

PMID:23997110

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

Cd48

Cd48 molecule

increases expression

Manganese results in increased expression of CD48 mRNA

NCBI chr13:84,184,884...84,209,144
Ensembl chr13:84,185,532...84,209,142

Cd8b

CD8 subunit beta

increases expression

Manganese results in increased expression of CD8B mRNA; Manganese results in increased expression of CD8B1 mRNA

NCBI chr 4:103,312,596...103,328,523
Ensembl chr 4:103,312,578...103,328,553

Cdkn2c

cyclin-dependent kinase inhibitor 2C

decreases expression

Manganese results in decreased expression of CDKN2C mRNA

NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278

Cdkn3

cyclin-dependent kinase inhibitor 3

decreases expression

Manganese results in decreased expression of CDKN3 mRNA

NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945

Cebpd

CCAAT/enhancer binding protein delta

increases expression

Manganese results in increased expression of CEBPD mRNA

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

Celsr1

cadherin, EGF LAG seven-pass G-type receptor 1

increases expression

Manganese results in increased expression of CELSR1 mRNA

NCBI chr 7:116,987,616...117,125,035
Ensembl chr 7:116,987,605...117,125,164

Cep128

centrosomal protein 128

decreases expression

Manganese results in decreased expression of CEP128 mRNA

NCBI chr 6:109,951,009...110,328,686
Ensembl chr 6:109,951,061...110,328,713

Chat

choline O-acetyltransferase

decreases activity
multiple interactions

Manganese results in decreased activity of CHAT protein
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of CHAT protein
Taurine inhibits the reaction [Manganese results in decreased activity of CHAT protein]

PMID:24885898 PMID:30738988

NCBI chr16:7,657,362...7,717,093
Ensembl chr16:7,657,362...7,717,093

Chmp4b

charged multivesicular body protein 4B

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased expression of CHMP4B protein

NCBI chr 3:143,170,822...143,211,376
Ensembl chr 3:143,170,902...143,210,844

Cks2

CDC28 protein kinase regulatory subunit 2

decreases expression

Manganese results in decreased expression of CKS2 mRNA

NCBI chr17:13,570,611...13,575,770

Cldn23

claudin 23

increases expression

Manganese results in increased expression of CLDN23 mRNA

NCBI chr16:56,413,677...56,415,401
Ensembl chr16:56,413,381...56,415,523

Cldnd1

claudin domain containing 1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CLDND1 mRNA

NCBI chr11:41,883,120...41,889,471
Ensembl chr11:41,883,134...41,889,354

Cln6

CLN6, transmembrane ER protein

increases abundance

CLN6 gene mutant form results in increased abundance of Manganese

PMID:23789114

NCBI chr 8:63,303,356...63,318,360
Ensembl chr 8:63,303,029...63,318,360

Cnot2

CCR4-NOT transcription complex, subunit 2

decreases expression

Manganese results in decreased expression of CNOT2 mRNA

NCBI chr 7:52,130,444...52,222,338
Ensembl chr 7:52,130,441...52,223,575

Cnot6l

CCR4-NOT transcription complex, subunit 6-like

increases expression

Manganese results in increased expression of CNOT6L mRNA

NCBI chr14:13,410,501...13,502,511
Ensembl chr14:13,411,281...13,498,203

Col12a1

collagen type XII alpha 1 chain

decreases expression

Manganese results in decreased expression of COL12A1 mRNA

NCBI chr 8:80,547,592...80,665,665
Ensembl chr 8:80,547,593...80,665,686

Cpm

carboxypeptidase M

decreases expression

Manganese results in decreased expression of CPM mRNA

NCBI chr 7:53,225,647...53,286,220
Ensembl chr 7:53,225,696...53,286,220

Creb1

cAMP responsive element binding protein 1

increases phosphorylation
decreases phosphorylation
multiple interactions
decreases expression

Manganese results in increased phosphorylation of CREB1 protein
Manganese results in decreased phosphorylation of CREB1 protein
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of CREB1 protein; NTF3 protein inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein]
[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in decreased phosphorylation of CREB1 protein]
Manganese results in decreased expression of CREB1 mRNA; Manganese results in decreased expression of CREB1 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; [manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein; CREB1 protein affects the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of BDNF mRNA]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; Rolipram inhibits the reaction [Manganese results in decreased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of CREB1 protein]; SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of CREB1 protein]

PMID:16787641 PMID:29205667 PMID:30951808 PMID:31161640 PMID:31676349 More...

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

Crh

corticotropin releasing hormone

multiple interactions

CRH protein inhibits the reaction [Manganese results in increased chemical synthesis of Cyclic AMP]

PMID:2153673

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

Crym

crystallin, mu

affects expression

Manganese affects the expression of CRYM protein

NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633

Csrp3

cysteine and glycine rich protein 3

increases expression

Manganese results in increased expression of CSRP3 mRNA

NCBI chr 1:98,528,067...98,546,647
Ensembl chr 1:98,528,068...98,546,653

Ctnna1

catenin alpha 1

decreases expression

Manganese results in decreased expression of CTNNA1 mRNA

NCBI chr18:26,728,246...26,860,911
Ensembl chr18:26,728,485...26,860,910

Ctnnb1

catenin beta 1

decreases expression

Manganese results in decreased expression of CTNNB1 mRNA

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

Cxcl12

C-X-C motif chemokine ligand 12

decreases expression

Manganese results in decreased expression of CXCL12 mRNA

PMID:23499988

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

Cxcl14

C-X-C motif chemokine ligand 14

increases expression

Manganese results in increased expression of CXCL14 mRNA

NCBI chr17:8,317,933...8,325,956
Ensembl chr17:8,317,933...8,324,839

Cxcl2

C-X-C motif chemokine ligand 2

increases expression

Manganese results in increased expression of CXCL2 mRNA

PMID:17175027 PMID:19782702 PMID:20224926

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

Cxcl6

C-X-C motif chemokine ligand 6

increases expression

Manganese results in increased expression of CXCL6 mRNA

NCBI chr14:17,310,089...17,312,303
Ensembl chr14:17,310,426...17,313,093

Cycs

cytochrome c, somatic

multiple interactions
affects localization

SNCA protein inhibits the reaction [Manganese affects the localization of CYCS protein]

PMID:25416158

NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054

Cyp11a1

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression

Manganese results in decreased expression of CYP11A1 protein

PMID:25981801

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

Cyp26b1

cytochrome P450, family 26, subfamily b, polypeptide 1

decreases expression

Manganese results in decreased expression of CYP26B1 mRNA

NCBI chr 4:117,041,808...117,058,628
Ensembl chr 4:117,041,808...117,058,628

Cyp2d4

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases response to substance

CYP2D6 gene polymorphism results in decreased susceptibility to Manganese

PMID:12171760

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

Cyp7a1

cytochrome P450 family 7 subfamily A member 1

multiple interactions
increases activity

[Manganese co-treated with Bilirubin] results in decreased activity of CYP7A1 protein
Manganese results in increased activity of CYP7A1 protein

PMID:12700418

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

Dach2

dachshund family transcription factor 2

increases expression

Manganese results in increased expression of DACH2 mRNA

NCBI chr X:78,718,963...79,018,023
Ensembl chr X:78,451,593...79,017,592

Dctn3

dynactin subunit 3

affects expression

Manganese affects the expression of DCTN3 protein

NCBI chr 5:56,881,085...56,889,041
Ensembl chr 5:56,881,085...56,889,102

Ddah1

dimethylarginine dimethylaminohydrolase 1

decreases expression
multiple interactions

Manganese deficiency results in decreased expression of DDAH1 protein
Paroxetine inhibits the reaction [Manganese deficiency results in decreased expression of DDAH1 protein]

PMID:21312047

NCBI chr 2:234,667,499...234,800,322
Ensembl chr 2:234,667,491...234,799,339

Ddit3

DNA-damage inducible transcript 3

increases expression
multiple interactions

Manganese results in increased expression of DDIT3 protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of DDIT3 mRNA
Manganese results in increased expression of DDIT3 mRNA

PMID:21477646 PMID:23499988 PMID:32574669

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

Dld

dihydrolipoamide dehydrogenase

decreases expression

Manganese results in decreased expression of DLD protein

PMID:25981801

NCBI chr 6:47,904,153...47,924,814
Ensembl chr 6:47,903,914...47,924,795

Dnah14

dynein axonemal heavy chain 14

decreases expression

Manganese results in decreased expression of DNAH14 mRNA

NCBI chr13:93,322,653...93,540,706
Ensembl chr13:93,322,711...93,538,646

Dnph1

2'-deoxynucleoside 5'-phosphate N-hydrolase 1

decreases expression

Manganese results in decreased expression of DNPH1 mRNA

NCBI chr 9:14,481,296...14,484,034
Ensembl chr 9:14,481,066...14,484,022

Dpp4

dipeptidylpeptidase 4

increases expression

Manganese results in increased expression of DPP4 mRNA

NCBI chr 3:46,962,243...47,043,870
Ensembl chr 3:46,962,243...47,043,901

Dr1

down-regulator of transcription 1

decreases expression

Manganese results in decreased expression of DR1 mRNA

NCBI chr14:1,458,223...1,469,578
Ensembl chr14:1,458,223...1,469,638

Drd2

dopamine receptor D2

decreases expression
affects expression

Manganese results in decreased expression of DRD2 mRNA
Manganese affects the expression of DRD2 protein

PMID:20224926 PMID:33881537

NCBI chr 8:49,708,903...49,772,888
Ensembl chr 8:49,708,927...49,772,875

Dscaml1

DS cell adhesion molecule-like 1

increases expression

Manganese results in increased expression of DSCAML1 mRNA

NCBI chr 8:45,740,298...46,057,322
Ensembl chr 8:45,740,298...46,057,320

Dspp

dentin sialophosphoprotein

increases expression

Manganese results in increased expression of DSPP mRNA

NCBI chr14:5,565,562...5,571,669
Ensembl chr14:5,565,629...5,571,672

Dusp1

dual specificity phosphatase 1

multiple interactions
decreases expression

[Manganese co-treated with Lipopolysaccharides] results in decreased expression of DUSP1 mRNA; [Manganese co-treated with Lipopolysaccharides] results in decreased expression of DUSP1 protein
Manganese results in decreased expression of DUSP1 mRNA; Manganese results in decreased expression of DUSP1 protein

PMID:20589745

NCBI chr10:16,680,489...16,683,276

Eif2a

eukaryotic translation initiation factor 2A

increases expression

Manganese results in increased expression of EIF2A protein

PMID:21477646

NCBI chr 2:142,761,303...142,794,767
Ensembl chr 2:142,761,416...142,795,068

Eif2ak2

eukaryotic translation initiation factor 2-alpha kinase 2

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein; GW 506033X inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein]; pyrazolanthrone inhibits the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased cleavage of EIF2AK2 protein]

PMID:32574669

NCBI chr 6:16,189,000...16,224,972
Ensembl chr 6:16,188,979...16,224,971

Eif2ak3

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2AK3 protein

PMID:32574669

NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911

Eif2s1

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased phosphorylation of EIF2S1 protein

PMID:32574669

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

Elf1

E74 like ETS transcription factor 1

decreases expression

Manganese results in decreased expression of ELF1 mRNA

NCBI chr15:54,890,644...54,986,721
Ensembl chr15:54,865,616...54,986,699

Eml2

EMAP like 2

increases expression

Manganese results in increased expression of EML2 mRNA

NCBI chr 1:78,827,595...78,859,343
Ensembl chr 1:78,828,080...78,859,341

Eno1

enolase 1

decreases activity

Manganese results in decreased activity of ENO1 protein

PMID:22191580

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336

Epo

erythropoietin

increases glycosylation

Manganese results in increased glycosylation of EPO protein

PMID:16937399

NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946

Ercc6l

ERCC excision repair 6 like, spindle assembly checkpoint helicase

decreases expression

Manganese results in decreased expression of ERCC6L mRNA

NCBI chr X:67,245,414...67,261,222
Ensembl chr X:67,245,414...67,280,756

Ereg

epiregulin

increases expression

Manganese results in increased expression of EREG mRNA

NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062

Erich1

glutamate-rich 1

increases expression

Manganese results in increased expression of ERICH1 mRNA

NCBI chr16:75,501,322...75,569,129
Ensembl chr16:75,501,384...75,569,128

Esr1

estrogen receptor 1

increases expression

Manganese results in increased expression of ESR1 protein

PMID:24845367

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

Exoc6

exocyst complex component 6

decreases expression

Manganese results in decreased expression of EXOC6 mRNA

NCBI chr 1:235,314,612...235,457,824
Ensembl chr 1:235,300,369...235,457,015

Eya4

EYA transcriptional coactivator and phosphatase 4

decreases expression

Manganese results in decreased expression of EYA4 mRNA

NCBI chr 1:22,172,275...22,415,978
Ensembl chr 1:22,172,275...22,415,976

coagulation factor II

multiple interactions
increases uptake

1-Methyl-3-isobutylxanthine inhibits the reaction [F2 protein results in increased uptake of Manganese]; Colforsin inhibits the reaction [F2 protein results in increased uptake of Manganese]; Nickel inhibits the reaction [F2 protein results in increased uptake of Manganese]; Tetradecanoylphorbol Acetate inhibits the reaction [F2 protein results in increased uptake of Manganese]

PMID:2125206

NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486

Fa2h

fatty acid 2-hydroxylase

increases expression

Manganese results in increased expression of FA2H mRNA

NCBI chr19:39,312,904...39,364,153
Ensembl chr19:39,312,906...39,364,153

Fam107a

family with sequence similarity 107, member A

decreases expression

Manganese results in decreased expression of FAM107A mRNA

NCBI chr15:16,608,362...16,630,398
Ensembl chr15:16,607,205...16,630,396

Fam180a

family with sequence similarity 180, member A

decreases expression

Manganese results in decreased expression of FAM180A mRNA

NCBI chr 4:63,992,867...64,008,047
Ensembl chr 4:63,992,867...64,008,047

Fancf

FA complementation group F

decreases expression

Manganese results in decreased expression of FANCF mRNA

NCBI chr 1:101,449,120...101,452,361
Ensembl chr 1:101,450,389...101,451,923

Fcgr1a

Fc gamma receptor 1A

decreases expression

Manganese results in decreased expression of FCGR1A mRNA

NCBI chr 2:183,851,075...183,860,077
Ensembl chr 2:183,851,077...183,859,994

Fgfbp1

fibroblast growth factor binding protein 1

decreases expression

Manganese results in decreased expression of FGFBP1 mRNA

NCBI chr14:67,103,686...67,107,492
Ensembl chr14:67,104,545...67,107,496

Fhl1

four and a half LIM domains 1

decreases expression

Manganese results in decreased expression of FHL1 mRNA

NCBI chr X:134,555,399...134,614,930
Ensembl chr X:134,555,479...134,614,928

Fibin

fin bud initiation factor homolog

increases expression

Manganese results in increased expression of FIBIN mRNA

PMID:21615908

NCBI chr 3:96,942,405...96,944,676
Ensembl chr 3:96,942,406...96,944,676

Flcn

folliculin

increases expression

Manganese results in increased expression of FLCN mRNA

NCBI chr10:44,588,621...44,607,808
Ensembl chr10:44,588,624...44,607,769

Fos

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
decreases expression

[Curcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]; [diacetylcurcumin co-treated with Manganese] inhibits the reaction [Kainic Acid results in increased expression of FOS protein]
Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased activity of [JUN protein binds to FOS protein]]; Manganese promotes the reaction [Tetradecanoylphorbol Acetate results in increased expression of FOS protein]
Manganese results in decreased expression of FOS protein

PMID:17043766 PMID:17827730 PMID:22561169

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

Foxn4

forkhead box N4

increases expression

Manganese results in increased expression of FOXN4 mRNA

NCBI chr12:42,336,706...42,359,932
Ensembl chr12:42,340,323...42,359,921

Foxo3

forkhead box O3

multiple interactions
affects localization

2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein]; 2-oxothiazolidine-4-carboxylic acid inhibits the reaction [Manganese affects the localization of FOXO3 protein]; 2-oxothiazolidine-4-carboxylic acid inhibits the reaction [Manganese results in increased expression of FOXO3 protein]; Manganese results in increased expression of and results in increased phosphorylation of FOXO3 protein; SB 203580 inhibits the reaction [Manganese results in increased phosphorylation of FOXO3 protein]

PMID:24787138

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

Foxp2

forkhead box P2

increases expression

Manganese results in increased expression of FOXP2 mRNA

NCBI chr 4:43,133,827...43,712,442
Ensembl chr 4:43,133,912...43,711,683

Fth1

ferritin heavy chain 1

decreases expression
increases expression

Manganese results in decreased expression of FTH1 mRNA; Manganese results in decreased expression of FTH1 protein
Manganese results in increased expression of FTH1 protein

PMID:16545456 PMID:16568477 PMID:16740617 PMID:17469137

NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424

Fxyd2

FXYD domain-containing ion transport regulator 2

increases expression

Manganese results in increased expression of FXYD2 mRNA

NCBI chr 8:45,712,887...45,720,032
Ensembl chr 8:45,712,903...45,720,203

Gabbr2

gamma-aminobutyric acid type B receptor subunit 2

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in increased expression of GABBR2 protein

PMID:32659473

NCBI chr 5:60,947,517...61,288,104
Ensembl chr 5:60,947,526...61,288,104

Gabra1

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of GABRA1 protein

PMID:32659473

NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864

Gabrg2

gamma-aminobutyric acid type A receptor subunit gamma 2

increases expression

Manganese results in increased expression of GABRG2 mRNA

NCBI chr10:26,376,805...26,463,680
Ensembl chr10:26,374,694...26,464,346

Gadd45a

growth arrest and DNA-damage-inducible, alpha

increases expression

Manganese results in increased expression of GADD45A mRNA

PMID:23499988

NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115

Gal

galanin and GMAP prepropeptide

increases expression

Manganese results in increased expression of GAL mRNA

NCBI chr 1:200,650,439...200,655,302
Ensembl chr 1:200,650,439...200,654,959

Gcfc2

GC-rich sequence DNA-binding factor 2

decreases expression

Manganese results in decreased expression of GCFC2 mRNA

NCBI chr 4:114,481,613...114,519,268
Ensembl chr 4:114,481,607...114,519,962

Gdap2

ganglioside-induced differentiation-associated-protein 2

increases expression

Manganese results in increased expression of GDAP2 mRNA

NCBI chr 2:187,528,514...187,585,270
Ensembl chr 2:187,528,513...187,585,270

Gdf15

growth differentiation factor 15

increases expression

Manganese results in increased expression of GDF15 mRNA

NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055

Gfap

glial fibrillary acidic protein

decreases expression
affects expression
increases expression

Manganese results in decreased expression of GFAP mRNA
Manganese affects the expression of GFAP protein
Manganese results in increased expression of GFAP mRNA; Manganese results in increased expression of GFAP protein

PMID:19782702 PMID:20224926 PMID:23832297 PMID:24885898

NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589

Gja5

gap junction protein, alpha 5

decreases expression

Manganese results in decreased expression of GJA5 mRNA

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

Gldn

gliomedin

decreases expression

Manganese results in decreased expression of GLDN mRNA

NCBI chr 8:54,679,015...54,723,198
Ensembl chr 8:54,679,119...54,723,196

Glud1

glutamate dehydrogenase 1

decreases expression
multiple interactions

Manganese deficiency results in decreased expression of GLUD1 protein
Paroxetine inhibits the reaction [Manganese deficiency results in decreased expression of GLUD1 protein]

PMID:21312047

NCBI chr16:9,640,312...9,673,961
Ensembl chr16:9,640,312...9,673,957

Glul

glutamate-ammonia ligase

affects expression
decreases expression

Manganese affects the expression of GLUL mRNA; Manganese affects the expression of GLUL protein
Manganese results in decreased expression of GLUL mRNA; Manganese results in decreased expression of GLUL protein

PMID:16842851 PMID:16943606

NCBI chr13:65,969,064...66,035,121
Ensembl chr13:66,025,630...66,035,108

Gnrh1

gonadotropin releasing hormone 1

increases expression

Manganese results in increased expression of GNRH1 mRNA

PMID:23997110

NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581
Ensembl chr15:41,972,905...41,973,581

Gper1

G protein-coupled estrogen receptor 1

multiple interactions

[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in decreased susceptibility to Manganese

PMID:22645130

NCBI chr12:15,217,217...15,222,679
Ensembl chr12:15,217,442...15,221,889

Gpr18

G protein-coupled receptor 18

decreases expression

Manganese results in decreased expression of GPR18 mRNA

NCBI chr15:98,997,427...99,001,177
Ensembl chr15:98,997,259...99,001,470

Gpr34

G protein-coupled receptor 34

decreases expression

Manganese results in decreased expression of GPR34 mRNA

NCBI chr X:9,104,829...9,113,796
Ensembl chr X:9,104,565...9,148,601

Grin1

glutamate ionotropic receptor NMDA type subunit 1

decreases expression

Manganese results in decreased expression of GRIN1 mRNA; Manganese results in decreased expression of GRIN1 protein

PMID:19643132 PMID:29205667

NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603

Grin2a

glutamate ionotropic receptor NMDA type subunit 2A

decreases expression

Manganese results in decreased expression of GRIN2A mRNA; Manganese results in decreased expression of GRIN2A protein

PMID:19643132 PMID:29205667

NCBI chr10:5,630,684...6,043,341
Ensembl chr10:5,631,369...6,044,637

Grin2b

glutamate ionotropic receptor NMDA type subunit 2B

decreases expression

Manganese results in decreased expression of GRIN2B mRNA; Manganese results in decreased expression of GRIN2B protein

PMID:19643132 PMID:29205667

NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279

Gsr

glutathione-disulfide reductase

decreases expression
multiple interactions

Manganese results in decreased expression of GSR mRNA
[manganese chloride results in increased abundance of Manganese] which results in decreased activity of GSR protein
[Arsenic co-treated with Cadmium co-treated with Lead co-treated with Mercury co-treated with Chromium co-treated with Nickel co-treated with Manganese co-treated with Iron] results in decreased activity of GSR protein

PMID:17175027 PMID:17176674 PMID:32445656

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

Gstp1

glutathione S-transferase pi 1

affects response to substance

GSTP1 gene polymorphism affects the susceptibility to Manganese

PMID:30930959

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

Gtf2h1

general transcription factor IIH subunit 1

decreases expression

Manganese results in decreased expression of GTF2H1 mRNA

NCBI chr 1:97,321,401...97,349,455
Ensembl chr 1:97,321,394...97,349,455

Gucy1a1

guanylate cyclase 1 soluble subunit alpha 1

multiple interactions

Manganese results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]

PMID:22171090

NCBI chr 2:167,418,615...167,482,293
Ensembl chr 2:167,418,640...167,481,671

Gucy1b1

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

Manganese results in increased activity of [GUCY1A1 protein binds to GUCY1B1 protein]

PMID:22171090

NCBI chr 2:167,348,824...167,398,983
Ensembl chr 2:167,348,825...167,398,916

Hamp

hepcidin antimicrobial peptide

decreases expression
multiple interactions

Manganese results in decreased expression of HAMP mRNA
[manganese chloride results in increased abundance of Manganese] promotes the reaction [Ethanol results in decreased expression of HAMP protein]; [manganese chloride results in increased abundance of Manganese] which results in decreased expression of HAMP protein

PMID:29020610 PMID:34590183

NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891

Hdac1

histone deacetylase 1

multiple interactions

Manganese promotes the reaction [RELA protein binds to HDAC1 protein]; Manganese promotes the reaction [YY1 protein binds to HDAC1 protein]
[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]; Hesperidin inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC1 protein]]

PMID:24469401 PMID:34800614

NCBI chr 5:141,853,992...141,881,057
Ensembl chr 5:141,853,989...141,881,111

Hdac3

histone deacetylase 3

multiple interactions

[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC3 protein]; silmitasertib inhibits the reaction [[manganese chloride results in increased abundance of Manganese] promotes the reaction [YY1 protein binds to HDAC3 protein]]

PMID:34800614

NCBI chr18:29,770,637...29,789,850
Ensembl chr18:29,770,636...29,793,856

Heph

hephaestin

increases expression

Manganese results in increased expression of HEPH mRNA

NCBI chr X:61,151,131...61,402,980
Ensembl chr X:61,296,345...61,402,980

Hexd

hexosaminidase D

multiple interactions

[manganese chloride results in increased abundance of Manganese] which results in decreased expression of HEXDC mRNA

NCBI chr10:106,479,781...106,498,799
Ensembl chr10:106,480,194...106,498,799

Hfe

homeostatic iron regulator

affects abundance

HFE protein affects the abundance of Manganese

PMID:18317567

NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502

Hif1a

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

Manganese results in increased expression of and results in increased activity of HIF1A protein
[[manganese chloride results in increased abundance of Manganese] which co-treated with Ethanol] results in increased expression of HIF1A protein; [manganese chloride results in increased abundance of Manganese] which results in increased expression of HIF1A protein
Manganese results in increased expression of HIF1A mRNA

PMID:16386771 PMID:17175027 PMID:34590183

NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261

Hif1an

hypoxia inducible factor 1 subunit alpha inhibitor

decreases expression

Manganese results in decreased expression of HIF1AN mRNA

NCBI chr 1:243,419,175...243,440,464
Ensembl chr 1:243,419,194...243,434,327

Hmgcr

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions
increases activity

[Manganese co-treated with Bilirubin] results in decreased activity of HMGCR protein
Manganese results in increased activity of HMGCR protein

PMID:12700418

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

Hmgcs2

3-hydroxy-3-methylglutaryl-CoA synthase 2

decreases expression

Manganese results in decreased expression of HMGCS2 mRNA

NCBI chr 2:185,875,609...185,903,505
Ensembl chr 2:185,875,616...185,902,130

Hmox1

heme oxygenase 1

increases expression
multiple interactions

Manganese results in increased expression of HMOX1 mRNA
[manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein; GW 506033X promotes the reaction [[manganese chloride results in increased abundance of Manganese] which results in increased expression of HMOX1 protein]

PMID:11181820 PMID:18948096 PMID:23832297 PMID:32574669

NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079

Hoxb9

homeo box B9

decreases expression

Manganese results in decreased expression of HOXB9 mRNA

NCBI chr10:81,237,312...81,240,818
Ensembl chr10:81,237,312...81,240,818

Hspa5

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions

Manganese results in increased expression of HSPA5 protein
[manganese chloride results in increased abundance of Manganese] which results in increased expression of HSPA5 mRNA

PMID:21477646 PMID:32574669

NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891

Hspa8

heat shock protein family A (Hsp70) member 8

multiple interactions

[Manganese binds to N'-((2-hydroxyphenyl)carbonothioyl)pyridine-2-carbohydrazide] which results in increased expression of HSPA8 protein

PMID:16600465

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

Htr1a

5-hydroxytryptamine receptor 1A

multiple interactions

Manganese affects the reaction [Serotonin inhibits the reaction [N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclohexanecarboxamide binds to HTR1A protein]]; Manganese inhibits the reaction [Guanosine Triphosphate affects the reaction [Serotonin binds to HTR1A protein]]

PMID:21126535

NCBI chr 2:36,694,174...36,695,442
Ensembl chr 2:36,694,174...36,695,442

Htt

huntingtin

decreases uptake
multiple interactions
decreases response to substance
decreases abundance

HTT protein mutant form results in decreased uptake of Manganese
Manganese results in decreased phosphorylation of and results in increased expression of HTT protein
HTT protein mutant form inhibits the reaction [Manganese results in decreased expression of UBQLN1 protein]; HTT protein mutant form inhibits the reaction [Manganese results in increased expression of NEFL protein]; Manganese inhibits the reaction [HTT protein mutant form affects the expression of SAE1 protein]
HTT gene mutant form results in decreased susceptibility to Manganese
HTT gene mutant form results in decreased abundance of Manganese

PMID:19845833 PMID:20547568 PMID:22191580 PMID:25099302

NCBI chr14:75,845,836...75,996,094
Ensembl chr14:75,845,836...75,995,070

Id2

inhibitor of DNA binding 2

increases expression

Manganese results in increased expression of ID2 mRNA

NCBI chr 6:41,740,556...41,742,393
Ensembl chr 6:41,728,946...41,744,400

Idh3a

isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha

affects binding

Manganese binds to IDH3A protein

PMID:16737955

NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084

Idh3g

isocitrate dehydrogenase (NAD(+)) 3 non-catalytic subunit gamma

affects binding
multiple interactions

Manganese binds to IDH3G protein
[manganese chloride results in increased abundance of Manganese] which results in decreased expression of IDH3G mRNA

PMID:16737955 PMID:35690225

NCBI chr X:151,515,244...151,524,175
Ensembl chr X:151,515,247...151,524,171

Ifng

interferon gamma

multiple interactions