lanthanoid atom - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	lanthanoid atom	go back to main search page
Accession:	CHEBI:33319	browse the term
Synonyms:	exact_synonym:	lanthanoids
	related_synonym:	Lanthanoide; Lanthanoidengruppe; Lanthanoidenreiche; Ln; lanthanide; lanthanides; lanthanoid

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Rat (443 ) Mouse (448 ) Human (460 ) Chinchilla (0 ) Bonobo (0 ) Dog (0 ) Squirrel (0 ) Pig (0 ) Green Monkey (0) Naked Mole-rat (0 ) All
Genes (443)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases expression

ISO

ceric oxide analog results in decreased expression of AKT1 mRNA

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

albumin

decreases expression
increases secretion
affects expression

EXP
ISO

ceric oxide results in decreased expression of ALB protein
ceric oxide results in increased secretion of ALB protein
ceric oxide affects the expression of ALB mRNA

PMID:22072870 PMID:23726862 PMID:29463257

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

adaptor related protein complex 3 subunit delta 1

decreases expression

ISO

ceric oxide analog results in decreased expression of AP3D1 mRNA

NCBI chr 7:9,620,909...9,656,350
Ensembl chr 7:8,970,291...9,005,643

G

apoptotic peptidase activating factor 1

increases expression

ISO

ceric oxide results in increased expression of APAF1 protein

NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

ceric oxide results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression
multiple interactions

ISO

ceric oxide results in decreased expression of BCL2 protein
[Air Pollutants results in increased abundance of ceric oxide] which results in decreased expression of BCL2 protein

PMID:24987704 PMID:36982514

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

baculoviral IAP repeat-containing 5

increases expression

EXP

ceric oxide results in increased expression of BIRC5 mRNA

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380

G

BRCA1, DNA repair associated

decreases expression

EXP

ceric oxide results in decreased expression of BRCA1 mRNA

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

carbonic anhydrase 9

multiple interactions

ISO

[Air Pollutants results in increased abundance of [Benzo(a)pyrene co-treated with ceric oxide]] which results in decreased expression of CA9 protein; [Air Pollutants results in increased abundance of ceric oxide] which results in decreased expression of CA9 protein

NCBI chr 5:62,559,024...62,565,626
Ensembl chr 5:57,763,206...57,769,838

G

caspase 3

increases cleavage
increases expression

ISO

ceric oxide results in increased cleavage of CASP3 protein
ceric oxide results in increased expression of CASP3 protein

PMID:24987704 PMID:26028148

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 7

affects expression

ISO

ceric oxide analog affects the expression of CASP7 mRNA

NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729

G

caspase 9

increases expression

ISO

ceric oxide results in increased expression of CASP9 protein

Ensembl chr 5:154,109,046...154,126,626

G

catalase

decreases activity
multiple interactions
affects expression

ISO
EXP

ceric oxide results in decreased activity of CAT protein
Acetylcysteine inhibits the reaction [ceric oxide results in decreased activity of CAT protein]
ceric oxide affects the expression of CAT protein

PMID:20457660 PMID:23416263

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 11

multiple interactions
increases expression

ISO
EXP

[Antigens, Dermatophagoides co-treated with ceric oxide] results in decreased expression of CCL11 mRNA; [Antigens, Dermatophagoides co-treated with ceric oxide] results in increased expression of CCL11 protein; ceric oxide promotes the reaction [Antigens, Dermatophagoides results in increased expression of CCL11 mRNA]
ceric oxide results in increased expression of CCL11 mRNA

PMID:29463257 PMID:29792201

NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926

G

C-C motif chemokine ligand 17

multiple interactions
increases expression

ISO
EXP

[Antigens, Dermatophagoides co-treated with ceric oxide] results in increased expression of CCL17 mRNA
ceric oxide results in increased expression of CCL17 mRNA

PMID:29463257 PMID:29792201

NCBI chr19:10,202,128...10,203,903
Ensembl chr19:10,202,128...10,203,819

G

C-C motif chemokine ligand 2

multiple interactions
increases secretion
increases expression

ISO
EXP

[Antigens, Dermatophagoides co-treated with ceric oxide] results in decreased expression of CCL2 mRNA
ceric oxide results in increased secretion of CCL2 protein
ceric oxide results in increased expression of CCL2 mRNA

PMID:29463257 PMID:29792201

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

multiple interactions
affects expression

ISO
EXP

[Antigens, Dermatophagoides co-treated with ceric oxide] results in increased expression of CCL20 mRNA
ceric oxide affects the expression of CCL20 mRNA

PMID:29463257 PMID:29792201

NCBI chr 9:91,837,139...91,839,736
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 22

increases expression

EXP

ceric oxide results in increased expression of CCL22 mRNA

NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400

G

C-C motif chemokine ligand 24

increases expression

EXP

ceric oxide results in increased expression of CCL24 mRNA

NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893

G

C-C motif chemokine ligand 26

multiple interactions

ISO

[Antigens, Dermatophagoides co-treated with ceric oxide] results in increased expression of CCL26 mRNA

NCBI chr12:21,109,384...21,114,336
Ensembl chr12:21,109,421...21,114,335

G

C-C motif chemokine ligand 3

increases expression

EXP

ceric oxide results in increased expression of CCL3 mRNA

NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 4

increases expression

EXP

ceric oxide results in increased expression of CCL4 mRNA

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 7

increases expression

EXP

ceric oxide results in increased expression of CCL7 mRNA

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

C-C motif chemokine ligand 9

increases expression

EXP

ceric oxide results in increased expression of CCL9 mRNA

NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369

G

C-C motif chemokine receptor 2

increases expression

EXP

ceric oxide results in increased expression of CCR2 mRNA

NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:123,734,430...123,742,100

G

CD177 molecule

multiple interactions

ISO

[Antigens, Dermatophagoides co-treated with ceric oxide] results in increased expression of CD177 mRNA

NCBI chr 1:89,467,926...89,488,490
Ensembl chr 1:80,340,034...80,360,621

G

CD40 ligand

decreases expression

EXP

ceric oxide results in decreased expression of CD40LG mRNA

NCBI chr X:140,164,341...140,176,057
Ensembl chr X:135,126,969...135,138,306

G

Cd63 molecule

increases expression

ISO

ceric oxide results in increased expression of CD63 protein

NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO

[Air Pollutants results in increased abundance of [Benzo(a)pyrene co-treated with ceric oxide]] which results in increased expression of CDKN1A mRNA; [Air Pollutants results in increased abundance of [Benzo(a)pyrene co-treated with ceric oxide]] which results in increased expression of CDKN1A protein; [Air Pollutants results in increased abundance of ceric oxide] which results in decreased expression of CDKN1A protein; [Air Pollutants results in increased abundance of ceric oxide] which results in increased expression of CDKN1A protein

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

ISO

[Air Pollutants results in increased abundance of [Benzo(a)pyrene co-treated with ceric oxide]] which results in decreased expression of CDKN1B protein

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982

G

chloride channel accessory 1

multiple interactions

ISO

[Antigens, Dermatophagoides co-treated with ceric oxide] results in increased expression of CLCA1 mRNA
[Antigens, Dermatophagoides co-treated with ceric oxide] results in increased expression of CLCA1 mRNA; ceric oxide promotes the reaction [Antigens, Dermatophagoides results in increased expression of CLCA1 protein]

NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369

G

C-type lectin domain containing 10A

multiple interactions

ISO

[Antigens, Dermatophagoides co-treated with ceric oxide] results in increased expression of CLEC10A mRNA

NCBI chr10:54,876,244...54,880,439
Ensembl chr10:54,876,260...54,880,435

G

C-X3-C motif chemokine ligand 1

increases expression

EXP

ceric oxide results in increased expression of CX3CL1 mRNA

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X3-C motif chemokine receptor 1

affects expression

EXP

ceric oxide affects the expression of CX3CR1 mRNA

NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014

G

C-X-C motif chemokine ligand 10

multiple interactions

ISO

ceric oxide inhibits the reaction [Antigens, Dermatophagoides results in increased expression of CXCL10 mRNA]

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 12

decreases expression

EXP

ceric oxide results in decreased expression of CXCL12 mRNA

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 6

multiple interactions

ISO

ceric oxide promotes the reaction [Antigens, Dermatophagoides results in increased expression of CXCL5 mRNA]

NCBI chr14:17,310,790...17,312,250
Ensembl chr14:17,310,426...17,313,093

G

C-X-C motif chemokine ligand 9

affects expression

EXP

ceric oxide affects the expression of CXCL9 mRNA

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

C-X-C motif chemokine receptor 2

increases expression

EXP

ceric oxide results in increased expression of CXCR2 mRNA

NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425

G

C-X-C motif chemokine receptor 3

increases expression

EXP

ceric oxide results in increased expression of CXCR3 mRNA

NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969

G

C-X-C motif chemokine receptor 5

decreases expression

EXP

ceric oxide results in decreased expression of CXCR5 mRNA

NCBI chr 8:53,738,878...53,756,813
Ensembl chr 8:44,843,413...44,857,893

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

ISO

[Air Pollutants results in increased abundance of [Benzo(a)pyrene co-treated with ceric oxide]] which results in increased expression of CYP1A1 mRNA; [Air Pollutants results in increased abundance of [Benzo(a)pyrene co-treated with ceric oxide]] which results in increased expression of CYP1A1 protein; [Antigens, Dermatophagoides co-treated with ceric oxide] results in increased expression of CYP1A1 mRNA

PMID:29792201 PMID:36982514

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily b, polypeptide 1

affects expression

EXP

ceric oxide affects the expression of CYP1B1 mRNA

NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917

G

drebrin-like

decreases expression

ISO

ceric oxide analog results in decreased expression of DBNL mRNA

NCBI chr14:80,666,115...80,681,155
Ensembl chr14:80,666,124...80,681,155

G

dickkopf WNT signaling pathway inhibitor 4

multiple interactions

ISO

[Air Pollutants results in increased abundance of [Benzo(a)pyrene co-treated with ceric oxide]] which results in decreased expression of DKK4 protein

NCBI chr16:69,403,215...69,406,580
Ensembl chr16:69,402,989...69,406,580

G

endothelial PAS domain protein 1

multiple interactions

ISO

[Air Pollutants results in increased abundance of [Benzo(a)pyrene co-treated with ceric oxide]] which results in decreased expression of EPAS1 protein; [Air Pollutants results in increased abundance of ceric oxide] which results in decreased expression of EPAS1 protein

NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:7,790,647...7,871,228

G

eosinophil peroxidase

decreases expression

EXP

ceric oxide results in decreased expression of EPX mRNA

NCBI chr10:73,164,096...73,175,180
Ensembl chr10:72,666,865...72,677,952

G

exonuclease 1

affects expression

EXP

ceric oxide affects the expression of EXO1 mRNA

NCBI chr13:87,809,725...87,834,654
Ensembl chr13:87,809,810...87,834,654

G

fatty acid binding protein 4

increases expression

EXP

ceric oxide results in increased expression of FABP4 mRNA

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578

G

glutamate-cysteine ligase, catalytic subunit

decreases expression

EXP

ceric oxide results in decreased expression of GCLC mRNA

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

decreases expression

EXP

ceric oxide results in decreased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535

G

glutathione peroxidase 2

decreases expression

EXP

ceric oxide results in decreased expression of GPX2 mRNA

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:95,493,589...95,496,877

G

hemoglobin alpha, adult chain 2

decreases expression

EXP

ceric oxide results in decreased expression of HBA1 mRNA

NCBI chr10:15,828,291...15,829,138
Ensembl chr10:15,307,815...15,338,392
Ensembl chr10:15,307,815...15,338,392

G

homeostatic iron regulator

decreases expression

ISO

ceric oxide analog results in decreased expression of HFE mRNA

NCBI chr17:41,413,451...41,421,502
Ensembl chr17:41,413,451...41,421,502

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

ISO

[Air Pollutants results in increased abundance of [Benzo(a)pyrene co-treated with ceric oxide]] which results in decreased expression of HIF1A protein; [Air Pollutants results in increased abundance of ceric oxide] which results in decreased expression of HIF1A protein

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

heme oxygenase 1

affects expression
increases expression
decreases expression
multiple interactions

ISO

ceric oxide analog affects the expression of HMOX1 mRNA
ceric oxide results in increased expression of HMOX1 protein
ceric oxide results in decreased expression of HMOX1 mRNA
ceric oxide inhibits the reaction [potassium bromate results in increased expression of HMOX1 mRNA]

PMID:19429248 PMID:22960666 PMID:25618551

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

inhibitor of DNA binding 2

decreases expression

ISO

ceric oxide analog results in decreased expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:41,728,946...41,744,400

G

interleukin 13

multiple interactions

ISO

ceric oxide inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IL13 mRNA]

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737

G

interleukin 1 alpha

increases expression

EXP

ceric oxide results in increased expression of IL1A mRNA

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression

EXP

ceric oxide results in increased expression of IL1B mRNA; ceric oxide results in increased expression of IL1B protein

PMID:21624445 PMID:29463257

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

increases expression

EXP

ceric oxide results in increased expression of IL1RN mRNA

NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 2 receptor subunit beta

decreases expression

EXP

ceric oxide results in decreased expression of IL2RB mRNA

NCBI chr 7:111,913,828...111,928,537
Ensembl chr 7:110,033,341...110,048,054

G

interleukin 2 receptor subunit gamma

increases expression

EXP

ceric oxide results in increased expression of IL2RG mRNA

NCBI chr X:70,435,340...70,439,052
Ensembl chr X:66,392,542...66,399,823

G

interleukin 4

multiple interactions

ISO

ceric oxide promotes the reaction [Antigens, Dermatophagoides results in increased expression of IL4 mRNA]

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

increases expression
multiple interactions

EXP
ISO

ceric oxide results in increased expression of IL6 protein
[Antigens, Dermatophagoides co-treated with ceric oxide] results in increased expression of IL6 mRNA

PMID:21624445 PMID:29792201

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

interferon regulatory factor 7

multiple interactions

ISO

ceric oxide inhibits the reaction [Antigens, Dermatophagoides results in increased expression of IRF7 mRNA]

NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832

G

kinesin family member 13B

increases expression

ISO

ceric oxide analog results in increased expression of KIF13B mRNA

NCBI chr15:38,908,257...39,066,021
Ensembl chr15:38,924,624...39,084,879

G

KIT ligand

increases expression

ISO

ceric oxide analog results in increased expression of KITLG mRNA

NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214

G

DNA ligase 4

affects expression

EXP

ceric oxide affects the expression of LIG4 mRNA

NCBI chr16:86,220,345...86,228,930
Ensembl chr16:79,518,312...79,527,040

G

lactoperoxidase

increases expression

EXP

ceric oxide results in increased expression of LPO mRNA; ceric oxide results in increased expression of LPO protein

NCBI chr10:73,104,170...73,124,683
Ensembl chr10:72,606,944...72,626,535

G

mitogen activated protein kinase 1

increases phosphorylation
multiple interactions

ISO

ceric oxide results in increased phosphorylation of MAPK1 protein
Acetylcysteine inhibits the reaction [ceric oxide results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

ISO

Acetylcysteine inhibits the reaction [ceric oxide results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 12

multiple interactions
increases expression

ISO
EXP

ceric oxide promotes the reaction [Antigens, Dermatophagoides results in increased expression of MMP12 mRNA]
ceric oxide results in increased expression of MMP12 mRNA; ceric oxide results in increased expression of MMP12 protein

PMID:29463257 PMID:29792201

NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:4,581,785...4,599,611

G

matrix metallopeptidase 9

increases activity
increases secretion

ISO

ceric oxide results in increased activity of MMP9 protein
ceric oxide results in increased secretion of MMP9 protein

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

increases secretion
increases expression

ISO
EXP

ceric oxide results in increased secretion of MPO protein
ceric oxide results in increased expression of MPO mRNA

PMID:23726862 PMID:29463257

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819

G

mutS homolog 5

increases expression

EXP

ceric oxide results in increased expression of MSH5 mRNA

NCBI chr20:3,773,867...3,793,337
Ensembl chr20:3,776,942...3,793,336

G

mucin 1, cell surface associated

multiple interactions

ISO

[Antigens, Dermatophagoides co-treated with ceric oxide] results in increased expression of MUC1 mRNA

NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733

G

mucin 5AC, oligomeric mucus/gel-forming

multiple interactions

ISO

[Antigens, Dermatophagoides co-treated with ceric oxide] results in increased expression of MUC5AC mRNA

NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475

G

mutY DNA glycosylase

decreases expression

EXP

ceric oxide results in decreased expression of MUTYH mRNA

NCBI chr 5:130,274,034...130,286,149
Ensembl chr 5:130,274,122...130,286,146

G

neutrophil cytosolic factor 2

increases expression
decreases expression

EXP

ceric oxide results in increased expression of NCF2 mRNA
ceric oxide results in decreased expression of NCF2 mRNA

NCBI chr13:67,505,492...67,536,015
Ensembl chr13:64,955,503...64,986,277

G

NFE2 like bZIP transcription factor 2

affects localization

ISO

ceric oxide affects the localization of NFE2L2 protein

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

ISO

[Air Pollutants results in increased abundance of [Benzo(a)pyrene co-treated with ceric oxide]] which results in decreased expression of NFKB1 protein

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

neuroglobin

decreases expression

EXP

ceric oxide results in decreased expression of NGB mRNA

NCBI chr 6:106,744,378...106,749,830
Ensembl chr 6:106,744,378...106,749,830

G

NADPH oxidase organizer 1

increases expression

EXP

ceric oxide results in increased expression of NOXO1 mRNA

NCBI chr10:13,723,253...13,726,008
Ensembl chr10:13,721,473...13,726,061

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

ISO

[Antigens, Dermatophagoides co-treated with ceric oxide] results in increased expression of NQO1 mRNA

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557

G

opioid binding protein/cell adhesion molecule-like

increases expression

EXP

ceric oxide results in increased expression of OPCML mRNA

NCBI chr 8:34,451,629...35,562,897
Ensembl chr 8:26,192,841...27,300,620

G

oncostatin M

affects expression

EXP

ceric oxide affects the expression of OSM mRNA

NCBI chr14:83,327,202...83,332,073
Ensembl chr14:79,104,344...79,108,313

G

platelet factor 4

increases expression

EXP

ceric oxide results in increased expression of PF4 mRNA

NCBI chr14:17,582,477...17,583,392
Ensembl chr14:17,298,308...17,299,365

G

paraoxonase 3

multiple interactions

ISO

[Air Pollutants results in increased abundance of [Benzo(a)pyrene co-treated with ceric oxide]] which results in decreased expression of PON3 protein

NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855

G

peroxiredoxin 1

multiple interactions

ISO

[Air Pollutants results in increased abundance of [Benzo(a)pyrene co-treated with ceric oxide]] which results in decreased oxidation of PRDX1 protein modified form; [Air Pollutants results in increased abundance of ceric oxide] which results in decreased oxidation of PRDX1 protein modified form

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:130,147,204...130,162,856

G

RT1 class I, locus CE16

decreases expression

ISO

ceric oxide analog results in decreased expression of HLA-A mRNA

NCBI chr20:3,261,656...3,265,548
Ensembl chr20:3,257,123...3,279,563

G

stearoyl-CoA desaturase

affects expression

EXP

ceric oxide affects the expression of SCD1 mRNA

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562

G

secreted and transmembrane 1B

decreases expression

ISO

ceric oxide analog results in decreased expression of SECTM1 mRNA

NCBI chr10:106,324,070...106,333,779
Ensembl chr10:106,325,203...106,333,769

G

sirtuin 2

multiple interactions

ISO

[Air Pollutants results in increased abundance of [Benzo(a)pyrene co-treated with ceric oxide]] which results in decreased expression of SIRT2 protein

NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:84,052,903...84,076,975

G

solute carrier family 26 member 4

multiple interactions

ISO

[Antigens, Dermatophagoides co-treated with ceric oxide] results in increased expression of SLC26A4 mRNA
[Antigens, Dermatophagoides co-treated with ceric oxide] results in increased expression of SLC26A4 mRNA; ceric oxide promotes the reaction [Antigens, Dermatophagoides results in increased expression of SLC26A4 mRNA]

NCBI chr 6:53,835,102...53,873,968
Ensembl chr 6:48,107,588...48,145,703

G

single-strand-selective monofunctional uracil-DNA glycosylase 1

increases expression

EXP

ceric oxide results in increased expression of SMUG1 mRNA

NCBI chr 7:134,288,565...134,302,179
Ensembl chr 7:134,287,675...134,297,226

G

superoxide dismutase 2

multiple interactions
increases expression

ISO

[Air Pollutants results in increased abundance of [Benzo(a)pyrene co-treated with ceric oxide]] which results in decreased expression of SOD2 protein; ceric oxide inhibits the reaction [potassium bromate results in increased expression of SOD2 mRNA]
ceric oxide results in increased expression of SOD2 mRNA

PMID:25618551 PMID:36982514

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

secreted phosphoprotein 1

decreases expression

EXP

ceric oxide results in decreased expression of SPP1 mRNA

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162

G

tafazzin, phospholipid-lysophospholipid transacylase

decreases expression

ISO

ceric oxide analog results in decreased expression of TAFAZZIN mRNA

NCBI chr X:152,065,539...152,076,178
Ensembl chr X:152,065,609...152,074,001

G

TIR domain containing adaptor protein

decreases expression

ISO

ceric oxide analog results in decreased expression of TIRAP mRNA

NCBI chr 8:33,531,724...33,548,508
Ensembl chr 8:33,531,725...33,547,432

G

toll-like receptor 6

decreases expression

ISO

ceric oxide analog results in decreased expression of TLR6 mRNA

NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685

G

tumor necrosis factor

increases expression

EXP
ISO

ceric oxide results in increased expression of TNF protein

PMID:21624445 PMID:27693598

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

TNF superfamily member 4

affects expression

EXP

ceric oxide affects the expression of TNFSF4 mRNA

NCBI chr13:76,256,654...76,280,133
Ensembl chr13:73,723,329...73,746,788

G

toll interacting protein

decreases expression

ISO

ceric oxide analog results in decreased expression of TOLLIP mRNA

NCBI chr 1:196,961,585...196,984,252
Ensembl chr 1:196,950,771...196,983,625

G

tumor protein p53

increases phosphorylation
multiple interactions

ISO

ceric oxide results in increased phosphorylation of TP53 protein
[Air Pollutants results in increased abundance of [Benzo(a)pyrene co-treated with ceric oxide]] which results in increased expression of TP53 protein; [Air Pollutants results in increased abundance of ceric oxide] which results in increased expression of TP53 protein

PMID:24987704 PMID:36982514

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

thymic stromal lymphopoietin

multiple interactions

ISO

[Antigens, Dermatophagoides co-treated with ceric oxide] results in increased expression of TSLP mRNA

NCBI chr18:24,723,990...24,728,419
Ensembl chr18:24,449,844...24,453,548

G

thioredoxin interacting protein

decreases expression

EXP

ceric oxide results in decreased expression of TXNIP mRNA

NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:184,092,991...184,096,886

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

affects expression

ISO

Cerium affects the expression of AHR mRNA

NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568

G

activating transcription factor 4

affects expression

ISO

Cerium affects the expression of ATF4 mRNA

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446

G

calcium voltage-gated channel subunit alpha1 G

multiple interactions

ISO

Cerium inhibits the reaction [CACNA1G protein results in increased transport of Barium]

NCBI chr10:79,851,886...79,919,926
Ensembl chr10:79,355,008...79,422,752

G

hypoxia inducible factor 1 subunit alpha

decreases expression

ISO

Cerium results in decreased expression of HIF1A mRNA

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

metal-regulatory transcription factor 1

decreases expression

ISO

Cerium results in decreased expression of MTF1 mRNA

NCBI chr 5:137,062,319...137,107,136
Ensembl chr 5:137,062,376...137,107,136

G

NFE2 like bZIP transcription factor 2

decreases expression

ISO

Cerium results in decreased expression of NFE2L2 mRNA

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

decreases expression

ISO

Cerium results in decreased expression of NFKB1 mRNA

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

peroxisome proliferator-activated receptor gamma

decreases expression

ISO

Cerium results in decreased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

G

signal transducer and activator of transcription 1

affects expression

ISO

Cerium affects the expression of STAT1 mRNA

NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540

G

signal transducer and activator of transcription 2

affects expression

ISO

Cerium affects the expression of STAT2 mRNA

NCBI chr 7:1,287,025...1,302,858
Ensembl chr 7:702,495...718,967

G

tumor protein p53

decreases expression

ISO

Cerium results in decreased expression of TP53 mRNA

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

X-box binding protein 1

decreases expression

ISO

Cerium results in decreased expression of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693

cerium trichloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

affects expression

ISO

cerous chloride affects the expression of ALB mRNA

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

arachidonate 12-lipoxygenase, 12S type

decreases expression
multiple interactions

ISO

cerous chloride results in decreased expression of ALOX12 mRNA
[cerous chloride co-treated with lanthanum chloride] results in decreased expression of ALOX12 mRNA

NCBI chr10:55,456,923...55,469,239
Ensembl chr10:54,958,271...54,970,542

G

aldehyde oxidase 1

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of AOX1 mRNA

NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:59,579,649...59,658,770

G

apolipoprotein A4

affects expression

ISO

cerous chloride affects the expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

apolipoprotein E

affects expression
multiple interactions

ISO

cerous chloride affects the expression of APOE mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of APOE mRNA

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932

G

beta-2 microglobulin

increases expression

ISO

cerous chloride results in increased expression of B2M mRNA

NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:109,095,729...109,101,766

G

catalase

multiple interactions
decreases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of CAT mRNA
cerous chloride results in decreased expression of CAT mRNA

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 5

increases expression
multiple interactions

ISO

cerous chloride results in increased expression of CCL5 mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of CCL5 mRNA

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377

G

copper chaperone for superoxide dismutase

multiple interactions
decreases expression

ISO

[cerous chloride co-treated with lanthanum chloride] affects the expression of CCS mRNA
cerous chloride results in decreased expression of CCS mRNA

NCBI chr 1:211,543,192...211,564,354
Ensembl chr 1:202,113,804...202,134,915

G

cyclin-dependent kinase inhibitor 1A

decreases expression

ISO

cerous chloride results in decreased expression of CDKN1A mRNA

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

carboxyl ester lipase

increases expression

ISO

cerous chloride results in increased expression of CEL mRNA

NCBI chr 3:11,883,532...11,891,035
Ensembl chr 3:11,883,532...11,891,035

G

complement factor D

affects expression

ISO

cerous chloride affects the expression of CFD mRNA

NCBI chr 7:10,463,773...10,465,496
Ensembl chr 7:9,813,150...9,815,053

G

component of inhibitor of nuclear factor kappa B kinase complex

increases expression

ISO

cerous chloride results in increased expression of CHUK mRNA; cerous chloride results in increased expression of CHUK protein

NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065

G

cytoglobin

affects expression
multiple interactions

ISO

cerous chloride affects the expression of CYGB mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of CYGB mRNA

NCBI chr10:102,376,506...102,386,272
Ensembl chr10:101,877,676...101,887,442

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases expression

ISO

cerous chloride results in increased expression of CYP1A1

NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 51

affects expression

ISO

cerous chloride affects the expression of CYP51 mRNA

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410
Ensembl chr 6:30,036,865...30,055,410

G

cytochrome P450 family 7 subfamily B member 1

increases expression

ISO

cerous chloride results in increased expression of CYP7B1 mRNA

NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698

G

cytochrome P450 family 8 subfamily B member 1

affects expression

ISO

cerous chloride affects the expression of CYP8B1 mRNA

NCBI chr 8:130,455,622...130,457,592
Ensembl chr 8:121,557,062...121,580,166

G

24-dehydrocholesterol reductase

decreases expression

ISO

cerous chloride results in decreased expression of DHCR24 mRNA

NCBI chr 5:126,573,366...126,599,940
Ensembl chr 5:121,344,575...121,371,137

G

7-dehydrocholesterol reductase

affects expression

ISO

cerous chloride affects the expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

dual oxidase 1

decreases expression
multiple interactions

ISO

cerous chloride results in decreased expression of DUOX1 mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of DUOX1 mRNA

NCBI chr 3:129,714,125...129,749,186
Ensembl chr 3:109,262,397...109,295,563

G

dual oxidase 2

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of DUOX2 mRNA

NCBI chr 3:129,680,543...129,698,886
Ensembl chr 3:109,226,924...109,245,902

G

dual specificity phosphatase 1

multiple interactions
affects expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of DUSP1 mRNA
cerous chloride affects the expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646

G

EBP, cholestenol delta-isomerase

affects expression

ISO

cerous chloride affects the expression of EBP mRNA

NCBI chr X:16,971,372...16,977,782
Ensembl chr X:14,299,448...14,305,826

G

enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase

affects expression

ISO

cerous chloride affects the expression of EHHADH mRNA

NCBI chr11:92,746,409...92,779,647
Ensembl chr11:79,241,938...79,275,188

G

epoxide hydrolase 2

affects expression
multiple interactions

ISO

cerous chloride affects the expression of EPHX2 mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of EPHX2 mRNA

NCBI chr15:44,465,447...44,503,157
Ensembl chr15:40,289,902...40,327,615

G

eosinophil peroxidase

decreases expression

ISO

cerous chloride results in decreased expression of EPX mRNA

NCBI chr10:73,164,096...73,175,180
Ensembl chr10:72,666,865...72,677,952

G

forkhead box M1

multiple interactions
decreases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of FOXM1 mRNA
cerous chloride results in decreased expression of FOXM1 mRNA

NCBI chr 4:163,325,628...163,338,100
Ensembl chr 4:161,638,816...161,650,684

G

ferritin heavy chain 1

increases expression

ISO

cerous chloride results in increased expression of FTH1 mRNA

NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424

G

glyceraldehyde-3-phosphate dehydrogenase

decreases expression
multiple interactions

ISO

cerous chloride results in decreased expression of GAPDH mRNA
[cerous chloride co-treated with lanthanum chloride] results in decreased expression of GAPDH mRNA

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions

ISO

cerous chloride results in increased expression of GCLC mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of GCLC mRNA

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

decreases expression

ISO

cerous chloride results in decreased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535

G

glycerol-3-phosphate dehydrogenase 2

affects expression

ISO

cerous chloride affects the expression of GPD2 mRNA

NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901

G

glutathione peroxidase 2

decreases expression

ISO

cerous chloride results in decreased expression of GPX2 mRNA

NCBI chr 6:101,226,745...101,230,033
Ensembl chr 6:95,493,589...95,496,877

G

glutathione peroxidase 3

multiple interactions
affects expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of GPX3 mRNA
cerous chloride affects the expression of GPX3 mRNA

NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,028,570...39,037,035

G

glutathione peroxidase 4

affects expression

ISO

cerous chloride affects the expression of GPX4 mRNA

NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982

G

glutathione peroxidase 7

decreases expression
multiple interactions

ISO

cerous chloride results in decreased expression of GPX7 mRNA
[cerous chloride co-treated with lanthanum chloride] results in decreased expression of GPX7 mRNA

NCBI chr 5:128,373,881...128,381,866
Ensembl chr 5:123,144,331...123,153,004

G

growth factor receptor bound protein 2

affects expression

ISO

cerous chloride affects the expression of GRB2 mRNA

NCBI chr10:101,380,354...101,448,138
Ensembl chr10:100,869,718...100,949,309

G

glutathione S-transferase pi 1

decreases expression

ISO

cerous chloride results in decreased expression of GSTP1 mRNA

NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226

G

glutathione S-transferase zeta 1

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of GSTZ1 mRNA

NCBI chr 6:112,525,576...112,536,228
Ensembl chr 6:106,794,074...106,805,284

G

general transcription factor II I

decreases expression

ISO

cerous chloride results in decreased expression of GTF2I mRNA

NCBI chr12:22,400,933...22,476,243
Ensembl chr12:22,401,431...22,476,243

G

heme oxygenase 1

multiple interactions
affects expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of HMOX1 mRNA
cerous chloride affects the expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

heat shock protein family A (Hsp70) member 1A

decreases expression

ISO

cerous chloride results in decreased expression of HSPA1A mRNA

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227

G

interferon gamma

increases expression

ISO

cerous chloride results in increased expression of IFNG

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

inhibitor of nuclear factor kappa B kinase subunit beta

increases expression

ISO

cerous chloride results in increased expression of IKBKB mRNA; cerous chloride results in increased expression of IKBKB protein

NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250

G

interleukin 10

increases expression

ISO

cerous chloride results in increased expression of IL10

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 18

increases expression

ISO

cerous chloride results in increased expression of IL18

NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887

G

interleukin 1 beta

increases expression

ISO

cerous chloride results in increased expression of IL1B

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2

decreases expression
increases expression

ISO

cerous chloride results in decreased expression of IL2 mRNA; cerous chloride results in decreased expression of IL2 protein
cerous chloride results in increased expression of IL2

PMID:21656643 PMID:23712967

NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566

G

interleukin 4

increases expression

ISO

cerous chloride results in increased expression of IL4

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
increases expression

ISO

IL6 mutant form inhibits the reaction [cerous chloride results in increased expression of SAA protein]
cerous chloride results in increased expression of IL6; cerous chloride results in increased expression of IL6 protein

PMID:16204935 PMID:23712967

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

Jun proto-oncogene, AP-1 transcription factor subunit

affects expression

ISO

cerous chloride affects the expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

lactoperoxidase

multiple interactions
increases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of LPO mRNA
cerous chloride results in increased expression of LPO mRNA

NCBI chr10:73,104,170...73,124,683
Ensembl chr10:72,606,944...72,626,535

G

microtubule-associated protein 1 light chain 3 beta

increases expression

ISO

cerous chloride results in increased expression of MAP1LC3B protein

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

mitogen-activated protein kinase kinase kinase kinase 4

increases expression

ISO

cerous chloride results in increased expression of MAP4K4 mRNA; cerous chloride results in increased expression of MAP4K4 protein

NCBI chr 9:49,696,573...49,822,353
Ensembl chr 9:42,200,278...42,326,698

G

myoglobin

increases expression
multiple interactions

ISO

cerous chloride results in increased expression of MB mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of MB mRNA

NCBI chr 7:110,640,511...110,647,742
Ensembl chr 7:108,759,904...108,767,383

G

mannose binding lectin 2

decreases expression
multiple interactions

ISO

cerous chloride results in decreased expression of MBL2 mRNA
[cerous chloride co-treated with lanthanum chloride] results in decreased expression of MBL2 mRNA

NCBI chr 1:237,429,873...237,465,567

G

macrophage migration inhibitory factor

increases expression

ISO

cerous chloride results in increased expression of MIF

NCBI chr20:12,790,919...12,791,784
Ensembl chr20:12,790,902...12,799,504
Ensembl chr 4:12,790,902...12,799,504

G

myeloperoxidase

affects expression

ISO

cerous chloride affects the expression of MPO mRNA

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819

G

mitochondrial inner membrane protein MPV17

multiple interactions
decreases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of MPV17 mRNA
cerous chloride results in decreased expression of MPV17 mRNA

NCBI chr 6:30,941,693...30,956,389
Ensembl chr 6:25,222,896...25,236,244

G

methionine sulfoxide reductase A

decreases expression

ISO

cerous chloride results in decreased expression of MSRA mRNA

NCBI chr15:38,363,459...38,677,406
Ensembl chr15:38,351,445...38,676,585

G

metallothionein 1

increases expression
multiple interactions

ISO

cerous chloride results in increased expression of MT1 protein
cerous chloride promotes the reaction [Zinc binds to MT1 protein]

PMID:15964310 PMID:16204935

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 2

multiple interactions
increases expression

ISO

cerous chloride promotes the reaction [Zinc binds to MT2 protein]
cerous chloride results in increased expression of MT2 protein

PMID:15964310 PMID:16204935

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784

G

neutrophil cytosolic factor 1

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of NCF1 mRNA

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646

G

neutrophil cytosolic factor 2

affects expression
multiple interactions

ISO

cerous chloride affects the expression of NCF2 mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of NCF2 mRNA

NCBI chr13:67,505,492...67,536,015
Ensembl chr13:64,955,503...64,986,277

G

nuclear factor kappa B subunit 1

increases expression

ISO

cerous chloride results in increased expression of NFKB1 mRNA; cerous chloride results in increased expression of NFKB1 protein

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

nuclear factor kappa B subunit 2

increases expression

ISO

cerous chloride results in increased expression of NFKB2 mRNA; cerous chloride results in increased expression of NFKB2 protein

NCBI chr 1:255,106,010...255,114,649
Ensembl chr 1:245,165,950...245,173,213

G

NFKB inhibitor beta

decreases expression

ISO

cerous chloride results in decreased expression of NFKBIB mRNA; cerous chloride results in decreased expression of NFKBIB protein

NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:84,046,295...84,053,862

G

nicotinamide N-methyltransferase

affects expression

ISO

cerous chloride affects the expression of NNMT mRNA

NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655

G

nitric oxide synthase 2

decreases expression
multiple interactions

ISO

cerous chloride results in decreased expression of NOS2 mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of NOS2 mRNA

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

nucleophosmin 1

multiple interactions

ISO

cerous chloride results in decreased expression of and affects the localization of NPM1 protein

NCBI chr10:18,245,739...18,255,913
Ensembl chr10:17,739,941...17,751,645
Ensembl chr X:17,739,941...17,751,645

G

5' nucleotidase, ecto

decreases expression

ISO

cerous chloride results in decreased expression of NT5E mRNA

NCBI chr 8:89,271,046...89,314,918
Ensembl chr 8:89,270,696...89,314,881

G

nudix hydrolase 1

multiple interactions
decreases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of NUDT1 mRNA
cerous chloride results in decreased expression of NUDT1 mRNA

NCBI chr12:19,416,411...19,423,448
Ensembl chr12:14,302,694...14,305,826

G

proliferating cell nuclear antigen

affects expression
multiple interactions

ISO

cerous chloride affects the expression of PCNA protein
[cerous chloride co-treated with lanthanum chloride] affects the expression of PCNA protein

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995

G

polynucleotide kinase 3'-phosphatase

decreases expression

ISO

cerous chloride results in decreased expression of PNKP mRNA

NCBI chr 1:95,341,465...95,346,921
Ensembl chr 1:95,341,620...95,346,920

G

peroxiredoxin 1

multiple interactions
decreases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of PRDX1 mRNA
cerous chloride results in decreased expression of PRDX1 mRNA

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:130,147,204...130,162,856

G

peroxiredoxin 2

decreases expression

ISO

cerous chloride results in decreased expression of PRDX2 mRNA

NCBI chr19:40,085,788...40,091,083
Ensembl chr19:23,180,930...23,186,194

G

peroxiredoxin 5

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of PRDX5 mRNA

NCBI chr 1:213,529,042...213,532,787
Ensembl chr 1:204,099,826...204,114,268

G

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of PREX1 mRNA

NCBI chr 3:175,724,939...175,875,764
Ensembl chr 3:155,306,950...155,456,688

G

prostaglandin-endoperoxide synthase 2

decreases expression

ISO

cerous chloride results in decreased expression of PTGS2 mRNA

NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188

G

peroxidasin

multiple interactions
decreases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of PXDN mRNA
cerous chloride results in decreased expression of PXDN mRNA

NCBI chr 6:52,308,347...52,385,943
Ensembl chr 6:46,580,761...46,658,345

G

RAD51 recombinase

multiple interactions

ISO

[cerous chloride co-treated with Cisplatin] results in increased expression of RAD51 protein

NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:106,100,381...106,125,035

G

RELA proto-oncogene, NF-kB subunit

increases expression

ISO

cerous chloride results in increased expression of RELA mRNA; cerous chloride results in increased expression of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

scavenger receptor class A, member 3

decreases expression

ISO

cerous chloride results in decreased expression of SCARA3 mRNA

NCBI chr15:44,315,422...44,348,416
Ensembl chr15:40,140,161...40,172,894

G

selenoprotein P

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of SELENOP mRNA

NCBI chr 2:54,225,736...54,236,022
Ensembl chr 2:52,498,339...52,508,852

G

sirtuin 2

multiple interactions
decreases expression
increases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of SIRT2 mRNA
cerous chloride results in decreased expression of SIRT2 mRNA
cerous chloride results in increased expression of SIRT2 mRNA

NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:84,052,903...84,076,975

G

superoxide dismutase 1

decreases activity

ISO

cerous chloride results in decreased activity of SOD1 protein

NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249

G

superoxide dismutase 2

decreases activity
multiple interactions

ISO

cerous chloride results in decreased activity of SOD2 protein
[cerous chloride co-treated with lanthanum chloride] results in increased expression of SOD2 mRNA

PMID:15964310 PMID:28954213

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

sequestosome 1

multiple interactions
affects expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of SQSTM1 mRNA
cerous chloride affects the expression of SQSTM1 mRNA

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673

G

sulfiredoxin 1

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of SRXN1 mRNA

NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:140,599,608...140,628,448

G

serine/threonine kinase 25

decreases expression
multiple interactions

ISO

cerous chloride results in decreased expression of STK25 mRNA
[cerous chloride co-treated with lanthanum chloride] results in decreased expression of STK25 mRNA

NCBI chr 9:101,609,218...101,621,458
Ensembl chr 9:94,161,836...94,174,244

G

transforming growth factor, beta 1

increases expression

ISO

cerous chloride results in increased expression of TGFB1

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

toll-like receptor 2

increases expression

ISO

cerous chloride results in increased expression of TLR2 mRNA; cerous chloride results in increased expression of TLR2 protein

NCBI chr 2:171,499,189...171,504,831
Ensembl chr 2:169,197,419...169,206,630

G

toll-like receptor 4

increases expression

ISO

cerous chloride results in increased expression of TLR4 mRNA; cerous chloride results in increased expression of TLR4 protein

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

increases expression

ISO

cerous chloride results in increased expression of TNF; cerous chloride results in increased expression of TNF mRNA; cerous chloride results in increased expression of TNF protein

PMID:21656643 PMID:23712967

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

thioredoxin 1

increases expression

ISO

cerous chloride results in increased expression of TXN mRNA

NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:72,711,933...72,724,629

G

thioredoxin reductase 1

increases expression

ISO

cerous chloride results in increased expression of TXNRD1 mRNA

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863

G

thioredoxin reductase 2

decreases expression

ISO

cerous chloride results in decreased expression of TXNRD2 mRNA

NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156

G

uncoupling protein 2

multiple interactions
decreases expression

ISO

[cerous chloride co-treated with lanthanum chloride] affects the expression of UCP2 mRNA
cerous chloride results in decreased expression of UCP2 mRNA

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611

G

zeta chain of T cell receptor associated protein kinase 70

affects expression

ISO

cerous chloride affects the expression of ZAP70 mRNA

NCBI chr 9:46,485,605...46,507,552
Ensembl chr 9:38,989,750...39,011,700

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calcium voltage-gated channel subunit alpha1 G

multiple interactions

ISO

Erbium inhibits the reaction [CACNA1G protein results in increased transport of Barium]

NCBI chr10:79,851,886...79,919,926
Ensembl chr10:79,355,008...79,422,752

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

decreases expression

ISO

gadobutrol results in decreased expression of ADIPOQ mRNA

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564

G

fatty acid binding protein 4

decreases expression

ISO

gadobutrol results in decreased expression of FABP4 mRNA

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578

G

peroxisome proliferator-activated receptor gamma

decreases expression

ISO

gadobutrol results in decreased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

gadodiamide hydrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adiponectin, C1Q and collagen domain containing

decreases expression

ISO

gadodiamide results in decreased expression of ADIPOQ mRNA; gadodiamide results in decreased expression of ADIPOQ protein

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564

G

AKT serine/threonine kinase 1

increases phosphorylation
multiple interactions

ISO

gadodiamide results in increased phosphorylation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of AKT1 protein]

NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921

G

aldehyde dehydrogenase 1 family, member A1

increases expression

ISO

gadodiamide results in increased expression of ALDH1A1 mRNA

NCBI chr 1:227,426,939...227,579,497
Ensembl chr 1:218,042,127...218,152,961

G

ankyrin repeat domain 22

increases expression

ISO

gadodiamide results in increased expression of ANKRD22 mRNA

NCBI chr 1:231,639,035...231,670,537
Ensembl chr 1:231,639,314...231,670,381

G

ATM serine/threonine kinase

increases expression

ISO

gadodiamide results in increased expression of ATM mRNA

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437

G

ATPase phospholipid transporting 8B1

increases expression

ISO

gadodiamide results in increased expression of ATP8B1 mRNA

NCBI chr18:58,016,382...58,157,213
Ensembl chr18:58,018,268...58,157,396

G

C-C motif chemokine ligand 2

increases expression
increases secretion

ISO
EXP

gadodiamide results in increased expression of CCL2 mRNA
gadodiamide results in increased expression of CCL2 mRNA; gadodiamide results in increased expression of CCL2 protein
gadodiamide results in increased secretion of CCL2 protein

PMID:20938346 PMID:20959327

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 4

increases expression

EXP

gadodiamide results in increased expression of CCL4 protein

NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231

G

C-C motif chemokine ligand 7

increases expression

EXP

gadodiamide results in increased expression of CCL7 protein

NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303

G

centrosomal protein 15

increases expression

ISO

gadodiamide results in increased expression of CEP15 mRNA

NCBI chr15:12,815,159...12,835,115
Ensembl chr15:12,818,385...12,833,838

G

C-X-C motif chemokine ligand 10

increases expression
increases secretion

ISO
EXP

gadodiamide results in increased expression of CXCL10 mRNA
gadodiamide results in increased expression of CXCL10 protein
gadodiamide results in increased secretion of CXCL10 protein

PMID:20938346 PMID:20959327

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 11

increases secretion
increases expression

ISO

gadodiamide results in increased secretion of CXCL11 protein
gadodiamide results in increased expression of CXCL11 mRNA

NCBI chr14:15,973,728...15,976,503
Ensembl chr14:15,689,424...15,692,271

G

C-X-C motif chemokine ligand 12

increases expression

ISO

gadodiamide results in increased expression of CXCL12 mRNA

NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 9

increases expression

ISO

gadodiamide results in increased expression of CXCL9 mRNA

NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435

G

fatty acid binding protein 4

decreases expression

ISO

gadodiamide results in decreased expression of FABP4 mRNA; gadodiamide results in decreased expression of FABP4 protein

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578

G

indoleamine 2,3-dioxygenase 1

increases expression

ISO

gadodiamide results in increased expression of IDO1 mRNA

NCBI chr16:67,430,654...67,442,726
Ensembl chr16:67,430,578...67,442,730

G

interferon-induced protein 44-like

increases expression

ISO

gadodiamide results in increased expression of IFI44L mRNA

NCBI chr 2:240,668,742...240,706,425
Ensembl chr 2:240,668,713...240,706,359

G

interferon-induced protein with tetratricopeptide repeats 3

increases expression

ISO

gadodiamide results in increased expression of IFIT3 mRNA

NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307

G

interferon gamma

increases expression

ISO

gadodiamide results in increased expression of IFNG mRNA; gadodiamide results in increased expression of IFNG protein

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

interleukin 13

increases expression

ISO

gadodiamide results in increased expression of IL13 mRNA; gadodiamide results in increased expression of IL13 protein

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737

G

interleukin 1 alpha

increases expression

EXP

gadodiamide results in increased expression of IL1A protein

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 4

increases expression
affects expression

ISO

gadodiamide results in increased expression of IL4 protein
gadodiamide affects the expression of IL4 mRNA

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

interleukin 4 induced 1

increases expression

ISO

gadodiamide results in increased expression of IL4I1 mRNA

NCBI chr 1:104,435,540...104,461,049
Ensembl chr 1:95,295,601...95,324,562

G

interleukin 6

affects expression
increases expression

ISO

gadodiamide affects the expression of IL6 protein
gadodiamide results in increased expression of IL6 mRNA

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

KIT ligand

increases expression

EXP

gadodiamide results in increased expression of KITLG protein

NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 1

multiple interactions
increases expression

ISO

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased expression of MMP1 protein]; U 0126 inhibits the reaction [gadodiamide results in increased expression of MMP1 protein]
gadodiamide results in increased expression of MMP1 mRNA; gadodiamide results in increased expression of MMP1 protein

NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097

G

nitric oxide synthase 2

increases expression

ISO

gadodiamide results in increased expression of NOS2 protein

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

neurexophilin and PC-esterase domain family, member 3

increases expression

ISO

gadodiamide results in increased expression of NXPE3 mRNA

NCBI chr11:44,726,905...44,777,694
Ensembl chr11:44,727,069...44,777,694

G

peroxisome proliferator-activated receptor gamma

decreases expression

ISO

gadodiamide results in decreased expression of PPARG mRNA; gadodiamide results in decreased expression of PPARG protein

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

G

RELA proto-oncogene, NF-kB subunit

increases localization

ISO

gadodiamide results in increased localization of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

ras homolog family member Q

increases expression

ISO

gadodiamide results in increased expression of RHOQ mRNA

NCBI chr 6:13,368,499...13,403,929
Ensembl chr 1:106,622,141...106,623,699

G

Ras-like without CAAX 1

increases expression

ISO

gadodiamide results in increased expression of RIT1 mRNA

NCBI chr 2:174,180,742...174,195,455
Ensembl chr 2:174,180,848...174,195,455

G

ring finger protein 125

increases expression

ISO

gadodiamide results in increased expression of RNF125 mRNA

NCBI chr18:12,254,066...12,275,719
Ensembl chr18:12,253,852...12,275,983

G

radical S-adenosyl methionine domain containing 2

increases expression

ISO

gadodiamide results in increased expression of RSAD2 mRNA

NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:43,047,658...43,059,699

G

solute carrier family 39 member 10

increases expression

ISO

gadodiamide results in increased expression of SLC39A10 mRNA

NCBI chr 9:62,331,281...62,454,754
Ensembl chr 9:54,876,141...54,960,325

G

sialophorin

increases expression

ISO

gadodiamide results in increased expression of SPN mRNA

NCBI chr 1:191,177,449...191,190,115
Ensembl chr 1:181,746,429...181,759,628

G

secreted phosphoprotein 1

increases expression

EXP

gadodiamide results in increased expression of SPP1 protein

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162

G

transforming growth factor, beta 1

increases expression

ISO
EXP

gadodiamide results in increased expression of TGFB1 mRNA; gadodiamide results in increased expression of TGFB1 protein

PMID:19404939 PMID:20938346

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

TIMP metallopeptidase inhibitor 1

increases expression
multiple interactions

ISO
EXP

gadodiamide results in increased expression of TIMP1 mRNA; gadodiamide results in increased expression of TIMP1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [gadodiamide results in increased expression of TIMP1 protein]; U 0126 inhibits the reaction [gadodiamide results in increased expression of TIMP1 protein]

PMID:19561517 PMID:20938346

NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664

G

ubiquitin D

increases expression

ISO

gadodiamide results in increased expression of UBD mRNA

NCBI chr20:1,390,734...1,392,685
Ensembl chr20:1,385,864...1,408,639
Ensembl chr20:1,385,864...1,408,639

G

vascular endothelial growth factor A

increases expression

ISO
EXP

gadodiamide results in increased expression of VEGFA mRNA; gadodiamide results in increased expression of VEGFA protein

PMID:19404939 PMID:20938346

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

G

WD repeat domain 5

increases expression

ISO

gadodiamide results in increased expression of WDR5 mRNA

NCBI chr 3:10,836,964...10,856,682
Ensembl chr 3:10,837,025...10,856,671

G

X-linked inhibitor of apoptosis

increases expression

ISO

gadodiamide results in increased expression of XIAP mRNA

NCBI chr X:125,756,107...125,803,979
Ensembl chr X:120,897,907...120,934,700

G

zinc finger protein 652

increases expression

ISO

gadodiamide results in increased expression of ZNF652 mRNA

NCBI chr10:80,626,555...80,706,397
Ensembl chr10:80,649,400...80,698,674

gadolinium atom

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA carboxylase alpha

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of ACACA mRNA

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,014,170...69,276,457

G

BCL2, apoptosis regulator

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

basic helix-loop-helix ARNT like 1

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of BMAL1 protein

NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:167,331,633...167,430,231

G

calcium voltage-gated channel subunit alpha1 G

multiple interactions

ISO

Gadolinium inhibits the reaction [CACNA1G protein results in increased transport of Barium]

NCBI chr10:79,851,886...79,919,926
Ensembl chr10:79,355,008...79,422,752

G

caspase 3

increases activity
multiple interactions

EXP
ISO

Gadolinium results in increased activity of CASP3 protein
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of CASP3 mRNA

PMID:20398695 PMID:34878122

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

calcium-sensing receptor

multiple interactions

EXP

[Gadolinium binds to and results in increased activity of CASR protein] which results in increased abundance of Calcium; [Gadolinium binds to and results in increased activity of CASR protein] which results in increased abundance of Inositol Phosphates; Gadolinium binds to and results in increased activity of CASR protein; Gadolinium inhibits the reaction [Calcium binds to and results in increased activity of CASR protein]

PMID:10231437 PMID:11071898

NCBI chr11:77,738,398...77,813,639
Ensembl chr11:64,235,251...64,304,811

G

catalase

multiple interactions

ISO

CAT protein inhibits the reaction [Gadolinium promotes the reaction [TRPC5 protein results in increased transport of Calcium]]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

cholinergic receptor, muscarinic 1

multiple interactions

ISO

Gadolinium inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]

NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356

G

carnitine palmitoyltransferase 1A

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of CPT1A mRNA

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055

G

DNA-damage inducible transcript 3

multiple interactions

ISO

Gadolinium inhibits the reaction [Glucose results in increased expression of DDIT3 protein]

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

dopamine receptor D1

multiple interactions

EXP

Gadolinium inhibits the reaction [SCH 23390 binds to DRD1 protein]

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

multiple interactions

EXP

Gadolinium inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875

G

G protein subunit alpha q

increases response to substance

ISO

GNAQ protein results in increased susceptibility to Gadolinium

NCBI chr 1:222,852,453...223,098,754
Ensembl chr 1:213,424,465...213,667,672

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of HIF1A mRNA

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

heat shock protein family A (Hsp70) member 5

multiple interactions

ISO

Gadolinium inhibits the reaction [Glucose results in increased expression of HSPA5 protein]

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891

G

intraflagellar transport 88

multiple interactions

ISO

Gadolinium inhibits the reaction [IFT88 protein mutant form results in increased uptake of Calcium]

NCBI chr15:35,685,678...35,786,875
Ensembl chr15:31,573,376...31,672,147

G

interleukin 1 beta

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of IL1B mRNA

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 6

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of IL6 mRNA

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

mitogen activated protein kinase 1

multiple interactions

EXP

Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK1 protein]; Gadolinium inhibits the reaction [Calcimycin results in increased phosphorylation of MAPK1 protein]

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions

EXP

Gadolinium inhibits the reaction [[Norepinephrine co-treated with Timolol] results in increased activity of MAPK3 protein]; Gadolinium inhibits the reaction [Calcimycin results in increased phosphorylation of MAPK3 protein]

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of NFE2L2 mRNA

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of NFKB1 mRNA

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of RELA protein

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

S100 calcium binding protein A6

affects response to substance

ISO

S100A6 protein affects the susceptibility to Gadolinium

NCBI chr 2:176,100,619...176,102,181
Ensembl chr 2:176,100,899...176,102,180

G

secreted phosphoprotein 1

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of SPP1 mRNA

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162

G

sequestosome 1

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of SQSTM1 mRNA

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673

G

transforming growth factor, beta 1

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of TGFB1 mRNA

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

transient receptor potential cation channel, subfamily A, member 1

multiple interactions

ISO

Gadolinium inhibits the reaction [allyl isothiocyanate results in increased activity of TRPA1 protein]

NCBI chr 5:9,163,060...9,217,325
Ensembl chr 5:4,379,999...4,433,570

G

transient receptor potential cation channel, subfamily C, member 3

multiple interactions

ISO

Gadolinium affects the localization of and results in decreased activity of TRPC3 protein

NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855

G

transient receptor potential cation channel, subfamily C, member 5

multiple interactions

ISO

2-aminoethoxydiphenyl borate promotes the reaction [resveratrol inhibits the reaction [Gadolinium promotes the reaction [TRPC5 protein results in increased transport of Calcium]]]; Ascorbic Acid inhibits the reaction [Gadolinium promotes the reaction [TRPC5 protein results in increased transport of Calcium]]; Calcium promotes the reaction [resveratrol inhibits the reaction [Gadolinium promotes the reaction [TRPC5 protein results in increased transport of Calcium]]]; CAT protein inhibits the reaction [Gadolinium promotes the reaction [TRPC5 protein results in increased transport of Calcium]]; Gadolinium promotes the reaction [TRPC5 protein results in increased transport of Calcium]; Gallic Acid inhibits the reaction [Gadolinium promotes the reaction [TRPC5 protein results in increased transport of Calcium]]; resveratrol inhibits the reaction [Gadolinium promotes the reaction [TRPC5 protein results in increased transport of Calcium]]; resveratrol promotes the reaction [Ascorbic Acid inhibits the reaction [Gadolinium promotes the reaction [TRPC5 protein results in increased transport of Calcium]]]

NCBI chr X:107,946,163...108,230,991
Ensembl chr X:107,939,131...108,230,991

G

transient receptor potential cation channel, subfamily C, member 6

decreases activity

ISO

Gadolinium results in decreased activity of TRPC6 protein

NCBI chr 8:14,044,216...14,148,808
Ensembl chr 8:5,758,935...5,828,092

G

transient receptor potential cation channel, subfamily M, member 6

multiple interactions

ISO

Gadolinium inhibits the reaction [TRPM6 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Calcium]]

NCBI chr 1:216,136,407...216,320,523
Ensembl chr 1:216,170,038...216,320,520

G

transient receptor potential cation channel, subfamily V, member 4

multiple interactions
decreases activity

EXP

[Gadolinium results in decreased activity of TRPV4 protein] which results in decreased susceptibility to Buthionine Sulfoximine

NCBI chr12:47,599,161...47,638,143
Ensembl chr12:41,938,560...41,977,517

G

transient receptor potential cation channel, subfamily V, member 6

multiple interactions
increases uptake

ISO

Gadolinium inhibits the reaction [TRPV6 protein results in increased uptake of Calcium]
TRPV6 protein results in increased uptake of Gadolinium

NCBI chr 4:70,507,347...70,523,013
Ensembl chr 4:70,507,348...70,523,017

gadolinium trichloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 4

multiple interactions

ISO

gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of ABCC4 mRNA]

NCBI chr15:101,948,387...102,182,912
Ensembl chr15:95,542,315...95,774,283

G

acetyl-CoA carboxylase alpha

multiple interactions

ISO

gadolinium chloride promotes the reaction [Ethanol results in decreased expression of ACACA protein]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of ACACA mRNA

PMID:28882574 PMID:34878122

NCBI chr10:69,511,627...69,773,888
Ensembl chr10:69,014,170...69,276,457

G

acyl-CoA thioesterase 1

multiple interactions

EXP

gadolinium chloride promotes the reaction [perfluoro-n-nonanoic acid results in increased expression of ACOT1 mRNA]

NCBI chr 6:109,367,274...109,375,268
Ensembl chr 6:103,636,041...103,644,163

G

actin alpha 2, smooth muscle

multiple interactions

EXP

gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]

NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554

G

adhesion G protein-coupled receptor E1

multiple interactions

EXP
ISO

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of ADGRE1 mRNA
gadolinium chloride inhibits the reaction [Ethanol results in increased expression of ADGRE1 protein]

PMID:25813056 PMID:28882574

NCBI chr 9:2,329,398...2,484,959
Ensembl chr 9:2,242,474...2,398,000

G

adiponectin, C1Q and collagen domain containing

decreases expression

ISO

gadolinium chloride results in decreased expression of ADIPOQ mRNA

NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564

G

apolipoprotein B

multiple interactions

EXP

gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of APOB mRNA]

NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497

G

activating transcription factor 4

affects expression

EXP

gadolinium chloride affects the expression of ATF4 mRNA

NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446

G

activating transcription factor 6

multiple interactions
increases expression
affects expression

EXP

Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ATF6 protein]
gadolinium chloride affects the expression of ATF6 mRNA

NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177

G

BCL2, apoptosis regulator

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

basic helix-loop-helix ARNT like 1

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of BMAL1 protein

NCBI chr 1:176,766,222...176,864,741
Ensembl chr 1:167,331,633...167,430,231

G

bone morphogenetic protein 2

multiple interactions

EXP

gadolinium chloride promotes the reaction [Carbon Tetrachloride results in increased expression of BMP2 mRNA]

NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397

G

caspase 3

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of CASP3 mRNA

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

catalase

multiple interactions

EXP

gadolinium chloride inhibits the reaction [[Triiodothyronine co-treated with Hexachlorocyclohexane] results in decreased activity of CAT protein]

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 2

multiple interactions

EXP

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CCL2 mRNA]; gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of CCL2 protein]

PMID:25813056 PMID:26177832

NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226

G

cyclin E1

increases expression

ISO

gadolinium chloride results in increased expression of CCNE1

NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101

G

CD163 molecule

multiple interactions

EXP

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD163 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD163 mRNA]

PMID:25813056 PMID:26177832

NCBI chr 4:157,085,080...157,118,470
Ensembl chr 4:157,085,093...157,117,878

G

Cd68 molecule

multiple interactions

ISO
EXP

gadolinium chloride inhibits the reaction [[Dietary Fats co-treated with bromodichloromethane] results in increased expression of CD68 mRNA]
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 mRNA; [gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of CD68 protein; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CD68 mRNA]

PMID:23438451 PMID:25813056 PMID:26177832

NCBI chr10:54,880,562...54,882,441
Ensembl chr10:54,381,815...54,383,697

G

carnitine palmitoyltransferase 1A

multiple interactions

EXP
ISO

gadolinium chloride promotes the reaction [perfluoro-n-nonanoic acid results in increased expression of CPT1A mRNA]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of CPT1A mRNA

PMID:22648072 PMID:34878122

NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055

G

C-X-C motif chemokine ligand 1

multiple interactions

EXP

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL1 mRNA]

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 2

multiple interactions

ISO
EXP

gadolinium chloride inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of CXCL2 mRNA]
gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of CXCL2 mRNA]

PMID:22157104 PMID:26177832

NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

multiple interactions

ISO

gadolinium chloride inhibits the reaction [Progesterone promotes the reaction [Halothane results in increased expression of CXCL1 mRNA]]; gadolinium chloride inhibits the reaction [Progesterone results in increased expression of CXCL1 mRNA]

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

EXP

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP1A2 protein]

NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 2, subfamily b, polypeptide 1

multiple interactions

EXP

gadolinium chloride inhibits the reaction [Phenobarbital results in increased expression of CYP2B1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B1 protein]

PMID:10918498 PMID:18202523

NCBI chr 1:90,646,098...90,669,762
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

multiple interactions

EXP

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B2 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2B2 protein]

NCBI chr 1:90,722,243...90,736,272
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

EXP

gadolinium chloride inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP2C11 protein]

NCBI chr 1:246,175,216...246,211,445
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily e, polypeptide 1

multiple interactions

EXP

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP2E1 protein]

NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions

EXP

gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 mRNA]; gadolinium chloride inhibits the reaction [Styrene results in increased expression of CYP3A2 protein]; gadolinium chloride inhibits the reaction [Trinitrobenzenesulfonic Acid results in decreased activity of and results in decreased expression of CYP3A2 protein]

PMID:18079364 PMID:18202523

NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 4, subfamily a, polypeptide 1

multiple interactions

EXP

gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of CYP4A1 mRNA]

NCBI chr 5:134,360,096...134,374,233
Ensembl chr 5:129,123,336...129,137,464

G

DNA-damage inducible transcript 3

multiple interactions
increases expression
affects expression

EXP

Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of DDIT3 protein]
gadolinium chloride affects the expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases expression

EXP

gadolinium chloride results in increased expression of EIF2AK3 protein

NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions
increases expression

EXP

Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of ERN1 protein]

NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029

G

fatty acid binding protein 4

decreases expression

ISO

gadolinium chloride results in decreased expression of FABP4 mRNA

NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578

G

fatty acid synthase

multiple interactions

EXP
ISO

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of FASN mRNA
gadolinium chloride promotes the reaction [Ethanol results in decreased expression of FASN protein]

PMID:25813056 PMID:28882574

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261

G

glutamic--pyruvic transaminase

multiple interactions

EXP
ISO

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of GPT protein]; gadolinium chloride inhibits the reaction [Vitamin A results in increased activity of GPT protein]
gadolinium chloride inhibits the reaction [Amiodarone promotes the reaction [Dexamethasone results in increased expression of GPT protein]]

PMID:8627517 PMID:25900201 PMID:26177832

NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494

G

hepcidin antimicrobial peptide

increases expression

EXP

gadolinium chloride results in increased expression of HAMP

NCBI chr 1:95,298,332...95,300,271
Ensembl chr 1:86,170,901...86,172,891

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of HIF1A mRNA

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

hemojuvelin BMP co-receptor

decreases expression

EXP

gadolinium chloride results in decreased expression of HJV

NCBI chr 2:184,065,944...184,069,851
Ensembl chr 2:184,065,970...184,069,850

G

high mobility group box 1

multiple interactions

EXP

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased secretion of HMGB1 protein]

NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565

G

3-hydroxy-3-methylglutaryl-CoA synthase 2

multiple interactions

EXP

gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of HMGCS2 mRNA]

NCBI chr 2:188,564,348...188,590,872
Ensembl chr 2:185,875,616...185,902,130

G

heat shock protein family A (Hsp70) member 1A

multiple interactions

EXP

gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of HSPA1A mRNA]; gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of HSPA1A protein]

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 5

increases expression
multiple interactions
affects expression

EXP

gadolinium chloride results in increased expression of HSPA5 protein
Acetylcysteine inhibits the reaction [gadolinium chloride results in increased expression of HSPA5 protein]
gadolinium chloride affects the expression of HSPA5 mRNA

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891

G

intercellular adhesion molecule 1

multiple interactions

ISO

gadolinium chloride inhibits the reaction [[Progesterone co-treated with Halothane] results in increased expression of ICAM1 mRNA]

NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438

G

interferon gamma

affects expression
increases expression

ISO

gadolinium chloride affects the expression of IFNG protein
gadolinium chloride results in increased expression of IFNG mRNA

PMID:15590129 PMID:19404939

NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375

G

insulin-like growth factor 1

multiple interactions

EXP

gadolinium chloride inhibits the reaction [Lipopolysaccharides results in decreased expression of IGF1 protein]

NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296

G

insulin-like growth factor binding protein 3

multiple interactions

EXP

gadolinium chloride inhibits the reaction [Lipopolysaccharides results in decreased expression of IGFBP3 protein]

NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083

G

interleukin 10

multiple interactions

EXP

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL10 mRNA]; gadolinium chloride inhibits the reaction [perfluoro-n-nonanoic acid results in decreased expression of IL10 protein]

PMID:22648072 PMID:26177832

NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313

G

interleukin 13

increases expression

ISO

gadolinium chloride results in increased expression of IL13 mRNA

NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737

G

interleukin 1 alpha

multiple interactions

EXP

gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A mRNA]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of IL1A protein]

NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822

G

interleukin 1 beta

increases expression
multiple interactions

EXP
ISO

gadolinium chloride results in increased expression of IL1B
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of IL1B mRNA
[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL1B mRNA; gadolinium chloride inhibits the reaction [perfluoro-n-nonanoic acid results in increased expression of IL1B protein]

PMID:19721414 PMID:22648072 PMID:25813056 PMID:34878122

NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 4

affects expression

ISO

gadolinium chloride affects the expression of IL4 mRNA; gadolinium chloride affects the expression of IL4 protein

NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750

G

interleukin 6

multiple interactions
increases expression

EXP
ISO

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of IL6 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of IL6 mRNA]; gadolinium chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of IL6 protein]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of IL6 mRNA
gadolinium chloride inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]
gadolinium chloride results in increased expression of IL6
gadolinium chloride results in increased expression of IL6 mRNA

PMID:12127824 PMID:12963478 PMID:19404939 PMID:19721414 PMID:24849676 More...

NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178

G

lipase E, hormone sensitive type

multiple interactions

ISO

gadolinium chloride inhibits the reaction [Ethanol results in increased phosphorylation of LIPE protein]

NCBI chr 1:90,093,433...90,112,117
Ensembl chr 1:80,965,627...80,984,310

G

lymphotoxin beta

increases expression

ISO

gadolinium chloride results in increased expression of LTB mRNA

NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381

G

mitogen activated protein kinase 1

decreases phosphorylation
multiple interactions
increases activity

ISO
EXP

gadolinium chloride results in decreased phosphorylation of MAPK1 protein
gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK1 protein]
gadolinium chloride results in increased activity of MAPK1 protein
Pertussis Toxin inhibits the reaction [gadolinium chloride results in decreased phosphorylation of MAPK1 protein]

PMID:12493575 PMID:21605080 PMID:26177832

NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

decreases phosphorylation
multiple interactions
increases activity

ISO
EXP

gadolinium chloride results in decreased phosphorylation of MAPK3 protein
gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased phosphorylation of MAPK3 protein]
Pertussis Toxin inhibits the reaction [gadolinium chloride results in decreased phosphorylation of MAPK3 protein]
gadolinium chloride results in increased activity of MAPK3 protein

PMID:12493575 PMID:21605080 PMID:26177832

NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863

G

matrix metallopeptidase 13

multiple interactions
increases expression

EXP

[Dimethylnitrosamine co-treated with gadolinium chloride] results in increased expression of MMP13 mRNA; SB 203580 inhibits the reaction [gadolinium chloride results in increased expression of MMP13 mRNA]

NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239

G

matrix metallopeptidase 14

multiple interactions
increases expression

EXP

[Dimethylnitrosamine co-treated with gadolinium chloride] results in increased expression of MMP14 mRNA
gadolinium chloride results in increased expression of MMP14 mRNA; gadolinium chloride results in increased expression of MMP14 protein

NCBI chr15:31,857,824...31,867,049
Ensembl chr15:27,887,727...27,899,864

G

matrix metallopeptidase 9

increases expression
multiple interactions

EXP

gadolinium chloride results in increased expression of MMP9 mRNA
SB 203580 inhibits the reaction [gadolinium chloride results in increased expression of MMP9 mRNA]

NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120

G

myeloperoxidase

multiple interactions

EXP

gadolinium chloride inhibits the reaction [Thioacetamide results in increased activity of MPO protein]

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819

G

NFE2 like bZIP transcription factor 2

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of NFE2L2 mRNA

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

G

nuclear factor kappa B subunit 1

multiple interactions

EXP
ISO

gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased activity of NFKB1 protein]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of NFKB1 mRNA

PMID:15025948 PMID:34878122

NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404

G

nitric oxide synthase 2

increases expression

EXP

gadolinium chloride results in increased expression of NOS2 mRNA

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

platelet derived growth factor subunit A

decreases expression

EXP

gadolinium chloride results in decreased expression of PDGFA mRNA

NCBI chr12:20,759,366...20,780,337
Ensembl chr12:15,645,541...15,666,497

G

platelet derived growth factor subunit B

decreases expression

EXP

gadolinium chloride results in decreased expression of PDGFB mRNA

NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984

G

peroxisome proliferator activated receptor alpha

multiple interactions

EXP

gadolinium chloride promotes the reaction [perfluoro-n-nonanoic acid results in increased expression of PPARA mRNA]

NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346

G

peroxisome proliferator-activated receptor gamma

decreases expression

ISO

gadolinium chloride results in decreased expression of PPARG mRNA

NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468

G

protein tyrosine kinase 2

increases activity

ISO

gadolinium chloride results in increased activity of PTK2

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

RB transcriptional corepressor 1

increases phosphorylation

ISO

gadolinium chloride results in increased phosphorylation of RB1 protein

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

EXP
ISO

gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased activity of RELA protein]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of RELA protein

PMID:15025948 PMID:34878122

NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484

G

S100 calcium binding protein A8

multiple interactions

EXP

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A8 mRNA]

NCBI chr 2:176,166,517...176,167,645
Ensembl chr 2:176,167,124...176,167,643

G

S100 calcium binding protein A9

multiple interactions

EXP

gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of S100A9 mRNA]

NCBI chr 2:176,190,361...176,193,182
Ensembl chr 2:176,190,361...176,193,230

G

stearoyl-CoA desaturase

multiple interactions

EXP
ISO

gadolinium chloride promotes the reaction [[Fructose co-treated with Copper deficiency] results in decreased expression of SCD1 mRNA]
gadolinium chloride promotes the reaction [Ethanol results in decreased expression of SCD1 protein]

PMID:25813056 PMID:28882574

NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562

G

solute carrier family 40 member 1

decreases expression

EXP

gadolinium chloride results in decreased expression of SLC40A1

NCBI chr 9:55,525,457...55,633,463
Ensembl chr 9:48,033,526...48,051,481

G

secreted phosphoprotein 1

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of SPP1 mRNA

NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162

G

sequestosome 1

multiple interactions

ISO

[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of SQSTM1 mRNA

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673

G

sterol regulatory element binding transcription factor 1

multiple interactions

EXP

gadolinium chloride inhibits the reaction [[Fructose co-treated with Copper deficiency] results in increased expression of SREBF1 protein]

NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650

G

transforming growth factor, beta 1

multiple interactions
increases expression
affects expression

EXP
ISO

gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 mRNA]; gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFB1 protein]; gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of TGFB1 mRNA]
[gadolinium chloride results in increased abundance of Gadolinium] which results in increased expression of TGFB1 mRNA
gadolinium chloride results in increased expression of TGFB1 protein
gadolinium chloride results in increased expression of TGFB1 mRNA
gadolinium chloride affects the expression of TGFB1 mRNA

PMID:11408273 PMID:15590129 PMID:15964588 PMID:19404939 PMID:34878122

NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847

G

toll-like receptor 4

multiple interactions

EXP

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TLR4 mRNA; gadolinium chloride inhibits the reaction [[Buthionine Sulfoximine results in increased susceptibility to Methimazole] which results in increased expression of TLR4 protein]

PMID:25813056 PMID:26177832

NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628

G

tumor necrosis factor

multiple interactions
decreases expression
increases expression

EXP
ISO

[gadolinium chloride co-treated with Fructose co-treated with Copper deficiency] results in decreased expression of TNF mRNA; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF mRNA]; gadolinium chloride inhibits the reaction [Hexachlorocyclohexane results in increased expression of TNF protein]; gadolinium chloride inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; gadolinium chloride inhibits the reaction [perfluoro-n-nonanoic acid results in increased expression of TNF protein]; gadolinium chloride inhibits the reaction [Thioacetamide results in increased expression of TNF protein]
gadolinium trichloride inhibits the reaction [estriol enhances the reaction [lipopolysaccharide increases expression of Tnf mRNA in liver]]
gadolinium chloride inhibits the reaction [lead acetate promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]]; gadolinium chloride inhibits the reaction [perfluorodecanoic acid results in increased expression of TNF protein]
gadolinium chloride results in increased expression of TNF
gadolinium chloride results in increased expression of TNF mRNA

CTD
RGD

PMID:12127824 PMID:12963478 PMID:14687926 PMID:15025948 PMID:15590129 More...

NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 11B

increases expression

ISO

gadolinium chloride results in increased expression of TNFRSF11B mRNA

NCBI chr 7:87,456,318...87,484,324
Ensembl chr 7:85,566,520...85,594,538

G

TNF receptor superfamily member 1A

increases expression

ISO

gadolinium chloride results in increased expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591

G

TNF superfamily member 10

increases expression

ISO

gadolinium chloride results in increased expression of TNFSF10 mRNA

NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135

G

TNF superfamily member 11

decreases expression

ISO

gadolinium chloride results in decreased expression of TNFSF11 mRNA

NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445

G

uncoupling protein 2

multiple interactions

EXP

gadolinium chloride inhibits the reaction [Carbon Tetrachloride results in increased expression of UCP2 mRNA]

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611

G

vascular endothelial growth factor A

increases expression

ISO

gadolinium chloride results in increased expression of VEGFA mRNA; gadolinium chloride results in increased expression of VEGFA protein

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

G

X-box binding protein 1

increases splicing

EXP

gadolinium chloride results in increased splicing of XBP1 mRNA

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calcium voltage-gated channel subunit alpha1 G

multiple interactions

ISO

Holmium inhibits the reaction [CACNA1G protein results in increased transport of Barium]

NCBI chr10:79,851,886...79,919,926
Ensembl chr10:79,355,008...79,422,752

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calcium voltage-gated channel subunit alpha1 G

multiple interactions

ISO

Lanthanum inhibits the reaction [CACNA1G protein results in increased transport of Barium]

NCBI chr10:79,851,886...79,919,926
Ensembl chr10:79,355,008...79,422,752

G

calcium/calmodulin-dependent protein kinase IV

decreases phosphorylation

EXP

Lanthanum results in decreased phosphorylation of CAMK4 protein

NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,585,269...24,802,487

G

calcium-sensing receptor

multiple interactions

ISO

Lanthanum inhibits the reaction [Calcium binds to and results in increased activity of CASR protein]; Lanthanum inhibits the reaction [CASR protein results in increased uptake of Calcium]; Lanthanum inhibits the reaction [Spermine binds to and results in increased activity of CASR protein]

PMID:17041782 PMID:21562303

NCBI chr11:77,738,398...77,813,639
Ensembl chr11:64,235,251...64,304,811

G

cholinergic receptor, muscarinic 1

multiple interactions

ISO

Lanthanum inhibits the reaction [[Carbachol results in increased activity of CHRM1 protein] which results in increased abundance of Calcium]

NCBI chr 1:205,567,226...205,583,001
Ensembl chr 1:205,567,220...205,582,356

G

cAMP responsive element binding protein 1

decreases phosphorylation

EXP

Lanthanum results in decreased phosphorylation of CREB1 protein

NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816

G

dopamine receptor D1

multiple interactions

EXP

Lanthanum inhibits the reaction [SCH 23390 binds to DRD1 protein]

NCBI chr17:10,545,488...10,550,029
Ensembl chr17:10,540,558...10,545,002

G

dopamine receptor D2

multiple interactions

EXP

Lanthanum inhibits the reaction [3-N-methylspiperone binds to DRD2 protein]

NCBI chr 8:58,605,403...58,669,339
Ensembl chr 8:49,708,927...49,772,875

G

early growth response 1

decreases expression

EXP

Lanthanum results in decreased expression of EGR1 mRNA

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

EXP

Lanthanum results in decreased expression of FOS mRNA

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

gamma-aminobutyric acid type A receptor subunit alpha 1

multiple interactions

ISO

[delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Lanthanum promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]

NCBI chr10:27,096,731...27,152,563
Ensembl chr10:26,595,160...26,650,864

G

gamma-aminobutyric acid type A receptor subunit beta 3

multiple interactions

ISO

[delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Lanthanum promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]

NCBI chr 1:108,467,047...108,702,522
Ensembl chr 1:108,296,124...108,698,961

G

gamma-aminobutyric acid type A receptor subunit gamma 2

multiple interactions

ISO

[delta-hexachlorocyclohexane co-treated with Lanthanum] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Lanthanum promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]

NCBI chr10:26,374,693...26,463,937
Ensembl chr10:26,374,694...26,464,346

G

heat shock protein family A (Hsp70) member 5

multiple interactions

ISO

Lanthanum binds to and results in increased expression of HSPA5 protein

NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891

G

insulin-like growth factor 2

multiple interactions

ISO

Lanthanum inhibits the reaction [IGF2 protein results in increased import of Calcium]

NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:197,814,410...197,823,018

G

insulin 2

decreases response to substance

ISO

Lanthanum results in decreased susceptibility to INS protein

NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

EXP

Lanthanum results in decreased expression of JUN mRNA

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

leptin

multiple interactions

ISO

Lanthanum promotes the reaction [LEP protein results in increased transport of Calcium]

NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262

G

transient receptor potential cation channel, subfamily C, member 6

decreases activity

ISO

Lanthanum results in decreased activity of TRPC6 protein

NCBI chr 8:14,044,216...14,148,808
Ensembl chr 8:5,758,935...5,828,092

G

transient receptor potential cation channel, subfamily M, member 6

multiple interactions

ISO

Lanthanum inhibits the reaction [TRPM6 protein affects the reaction [1-oleoyl-2-acetylglycerol results in increased transport of Calcium]]

NCBI chr 1:216,136,407...216,320,523
Ensembl chr 1:216,170,038...216,320,520

G

transient receptor potential cation channel, subfamily V, member 6

multiple interactions
increases uptake

ISO

Lanthanum inhibits the reaction [TRPV6 protein results in increased uptake of Calcium]
TRPV6 protein results in increased uptake of Lanthanum

NCBI chr 4:70,507,347...70,523,013
Ensembl chr 4:70,507,348...70,523,017

G

X-box binding protein 1

increases expression

ISO

Lanthanum results in increased expression of XBP1 mRNA alternative form

NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693

lanthanum trichloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

increases expression

ISO

lanthanum chloride results in increased expression of ALB mRNA

NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836

G

arachidonate 12-lipoxygenase, 12S type

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of ALOX12 mRNA

NCBI chr10:55,456,923...55,469,239
Ensembl chr10:54,958,271...54,970,542

G

aldehyde oxidase 1

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of AOX1 mRNA

NCBI chr 9:67,073,831...67,152,980
Ensembl chr 9:59,579,649...59,658,770

G

apolipoprotein E

increases expression
multiple interactions

ISO

lanthanum chloride results in increased expression of APOE mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of APOE mRNA

NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932

G

autophagy related 12

increases expression

EXP

lanthanum chloride results in increased expression of ATG12 protein

NCBI chr18:41,638,841...41,649,311
Ensembl chr18:39,452,191...39,462,418

G

autophagy related 7

increases expression

EXP

lanthanum chloride results in increased expression of ATG7 protein

NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:147,718,752...147,925,593

G

beta-2 microglobulin

increases expression

ISO

lanthanum chloride results in increased expression of B2M mRNA

NCBI chr 3:129,549,236...129,555,354
Ensembl chr 3:109,095,729...109,101,766

G

B-cell receptor-associated protein 31

decreases expression

EXP

lanthanum chloride results in decreased expression of BCAP31 protein

NCBI chr X:156,548,911...156,581,002
Ensembl chr X:151,397,576...151,428,506

G

beclin 1

increases expression

EXP

lanthanum chloride results in increased expression of BECN1 protein

NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742

G

calcium/calmodulin-dependent protein kinase IV

decreases phosphorylation

EXP

lanthanum chloride results in decreased phosphorylation of CAMK4 protein

NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,585,269...24,802,487

G

caspase 3

increases expression

EXP

lanthanum chloride results in increased expression of CASP3 protein

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

caspase 9

increases expression

EXP

lanthanum chloride results in increased expression of CASP9 protein

Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of CAT mRNA

NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 5

multiple interactions
increases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of CCL5 mRNA
lanthanum chloride results in increased expression of CCL5 mRNA

NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377

G

copper chaperone for superoxide dismutase

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] affects the expression of CCS mRNA

NCBI chr 1:211,543,192...211,564,354
Ensembl chr 1:202,113,804...202,134,915

G

cytoglobin

multiple interactions
affects expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of CYGB mRNA
lanthanum chloride affects the expression of CYGB mRNA

NCBI chr10:102,376,506...102,386,272
Ensembl chr10:101,877,676...101,887,442

G

dual oxidase 1

multiple interactions
increases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of DUOX1 mRNA
lanthanum chloride results in increased expression of DUOX1 mRNA

NCBI chr 3:129,714,125...129,749,186
Ensembl chr 3:109,262,397...109,295,563

G

dual oxidase 2

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of DUOX2 mRNA

NCBI chr 3:129,680,543...129,698,886
Ensembl chr 3:109,226,924...109,245,902

G

dual specificity phosphatase 1

increases expression
multiple interactions

ISO

lanthanum chloride results in increased expression of DUSP1 mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of DUSP1 mRNA

NCBI chr10:17,184,853...17,187,646

G

early growth response 1

decreases expression

EXP

lanthanum chloride results in decreased expression of EGR1 mRNA; lanthanum chloride results in decreased expression of EGR1 protein

PMID:19643171 PMID:21624330

NCBI chr18:26,737,078...26,740,877
Ensembl chr18:26,462,981...26,466,766

G

epoxide hydrolase 2

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of EPHX2 mRNA

NCBI chr15:44,465,447...44,503,157
Ensembl chr15:40,289,902...40,327,615

G

eosinophil peroxidase

increases expression

ISO

lanthanum chloride results in increased expression of EPX mRNA

NCBI chr10:73,164,096...73,175,180
Ensembl chr10:72,666,865...72,677,952

G

fission, mitochondrial 1

decreases expression

EXP

lanthanum chloride results in decreased expression of FIS1 protein

NCBI chr12:25,345,239...25,360,135
Ensembl chr12:19,708,558...19,723,377

G

Fos proto-oncogene, AP-1 transcription factor subunit

decreases expression

EXP

lanthanum chloride results in decreased expression of FOS protein

NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box M1

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of FOXM1 mRNA

NCBI chr 4:163,325,628...163,338,100
Ensembl chr 4:161,638,816...161,650,684

G

glyceraldehyde-3-phosphate dehydrogenase

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of GAPDH mRNA

NCBI chr 4:159,648,592...159,653,436
Ensembl chr 4:157,962,343...157,966,235

G

glutamate-cysteine ligase, catalytic subunit

increases expression
multiple interactions
decreases expression

ISO

lanthanum chloride results in increased expression of GCLC mRNA; lanthanum chloride results in increased expression of GCLC protein
[cerous chloride co-treated with lanthanum chloride] results in increased expression of GCLC mRNA
lanthanum chloride results in decreased expression of GCLC protein

PMID:24142884 PMID:28954213 PMID:33098623

NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544

G

glutaminase

decreases expression

EXP

lanthanum chloride results in decreased expression of GLS

NCBI chr 9:56,836,584...56,908,861
Ensembl chr 9:49,344,781...49,416,900

G

glutamate-ammonia ligase

decreases expression

EXP

lanthanum chloride results in decreased expression of GLUL

NCBI chr13:68,519,500...68,585,554
Ensembl chr13:66,025,630...66,035,108

G

glutathione peroxidase 3

increases expression
multiple interactions

ISO

lanthanum chloride results in increased expression of GPX3 mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of GPX3 mRNA

NCBI chr10:39,529,335...39,537,406
Ensembl chr10:39,028,570...39,037,035

G

glutathione peroxidase 7

multiple interactions
decreases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of GPX7 mRNA
lanthanum chloride results in decreased expression of GPX7 mRNA

NCBI chr 5:128,373,881...128,381,866
Ensembl chr 5:123,144,331...123,153,004

G

glutamate ionotropic receptor NMDA type subunit 1

increases expression

EXP

lanthanum chloride results in increased expression of GRIN1

NCBI chr 3:28,501,836...28,528,754
Ensembl chr 3:8,103,680...8,130,603

G

glutamate ionotropic receptor NMDA type subunit 2A

increases expression

EXP

lanthanum chloride results in increased expression of GRIN2A

NCBI chr10:6,136,458...6,560,003
Ensembl chr10:5,631,369...6,044,637

G

glutamate ionotropic receptor NMDA type subunit 2B

increases expression

EXP

lanthanum chloride results in increased expression of GRIN2B

NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:168,599,546...169,042,279

G

glutathione S-transferase zeta 1

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of GSTZ1 mRNA

NCBI chr 6:112,525,576...112,536,228
Ensembl chr 6:106,794,074...106,805,284

G

heme oxygenase 1

multiple interactions
decreases expression
increases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of HMOX1 mRNA
lanthanum chloride results in decreased expression of HMOX1 protein
lanthanum chloride results in increased expression of HMOX1 mRNA; lanthanum chloride results in increased expression of HMOX1 protein
lanthanum chloride results in decreased expression of HMOX1 mRNA

PMID:24142884 PMID:28954213 PMID:33098623

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

Jun proto-oncogene, AP-1 transcription factor subunit

decreases expression

EXP

lanthanum chloride results in decreased expression of JUN mRNA; lanthanum chloride results in decreased expression of JUN protein

NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656

G

potassium voltage-gated channel interacting protein 1

decreases expression

EXP

lanthanum chloride results in decreased expression of KCNIP1 protein

NCBI chr10:18,723,726...19,093,025
Ensembl chr10:18,219,519...18,589,045

G

Kelch-like ECH-associated protein 1

increases expression

ISO

lanthanum chloride results in increased expression of KEAP1 protein

NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862

G

lysosomal-associated membrane protein 2

increases expression

EXP

lanthanum chloride results in increased expression of LAMP2 protein

NCBI chr X:122,038,734...122,087,745
Ensembl chr X:117,057,606...117,260,522

G

lactate dehydrogenase A

decreases expression

EXP

lanthanum chloride results in decreased expression of LDHA mRNA; lanthanum chloride results in decreased expression of LDHA protein

NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472

G

lactate dehydrogenase B

increases expression

EXP

lanthanum chloride results in increased expression of LDHB mRNA; lanthanum chloride results in increased expression of LDHB protein

NCBI chr 4:177,159,389...177,177,408
Ensembl chr 4:175,428,385...175,446,403

G

lactoperoxidase

multiple interactions
increases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of LPO mRNA
lanthanum chloride results in increased expression of LPO mRNA

NCBI chr10:73,104,170...73,124,683
Ensembl chr10:72,606,944...72,626,535

G

microtubule-associated protein 1 light chain 3 beta

increases expression

EXP
ISO

lanthanum chloride results in increased expression of MAP1LC3B protein modified form

PMID:35090998 PMID:38253231

NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690
Ensembl chr16:49,665,791...49,677,690

G

myoglobin

multiple interactions
increases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of MB mRNA
lanthanum chloride results in increased expression of MB mRNA

NCBI chr 7:110,640,511...110,647,742
Ensembl chr 7:108,759,904...108,767,383

G

mannose binding lectin 2

multiple interactions
decreases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of MBL2 mRNA
lanthanum chloride results in decreased expression of MBL2 mRNA

NCBI chr 1:237,429,873...237,465,567

G

mitofusin 1

decreases expression

EXP

lanthanum chloride results in decreased expression of MFN1 protein

NCBI chr 2:117,240,525...117,288,017
Ensembl chr 2:115,313,401...115,359,640

G

mitofusin 2

decreases expression

EXP

lanthanum chloride results in decreased expression of MFN2 protein

NCBI chr 5:163,587,463...163,617,363
Ensembl chr 5:158,304,287...158,335,342

G

myeloperoxidase

affects expression

ISO

lanthanum chloride affects the expression of MPO mRNA

NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819

G

mitochondrial inner membrane protein MPV17

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of MPV17 mRNA

NCBI chr 6:30,941,693...30,956,389
Ensembl chr 6:25,222,896...25,236,244

G

mechanistic target of rapamycin kinase

decreases expression

EXP

lanthanum chloride results in decreased expression of MTOR protein modified form

NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311

G

neutrophil cytosolic factor 1

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of NCF1 mRNA

NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646

G

neutrophil cytosolic factor 2

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of NCF2 mRNA

NCBI chr13:67,505,492...67,536,015
Ensembl chr13:64,955,503...64,986,277

G

NFE2 like bZIP transcription factor 2

increases expression

ISO

lanthanum chloride results in increased expression of NFE2L2 mRNA; lanthanum chloride results in increased expression of NFE2L2 protein

PMID:24142884 PMID:33098623

NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737

G

nitric oxide synthase 2

increases expression
multiple interactions

ISO

lanthanum chloride results in increased expression of NOS2 mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of NOS2 mRNA

NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210

G

NADPH oxidase 4

increases expression

EXP

lanthanum chloride results in increased expression of NOX4 protein

NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406

G

nucleophosmin 1

multiple interactions

ISO

lanthanum chloride results in decreased expression of and affects the localization of NPM1 protein

NCBI chr10:18,245,739...18,255,913
Ensembl chr10:17,739,941...17,751,645
Ensembl chr X:17,739,941...17,751,645

G

NAD(P)H quinone dehydrogenase 1

decreases expression

ISO

lanthanum chloride results in decreased expression of NQO1 protein

NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557

G

nudix hydrolase 1

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of NUDT1 mRNA

NCBI chr12:19,416,411...19,423,448
Ensembl chr12:14,302,694...14,305,826

G

proliferating cell nuclear antigen

affects expression
multiple interactions

ISO

lanthanum chloride affects the expression of PCNA protein
[cerous chloride co-treated with lanthanum chloride] affects the expression of PCNA protein

NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995

G

peroxiredoxin 1

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of PRDX1 mRNA

NCBI chr 5:135,383,906...135,399,504
Ensembl chr 5:130,147,204...130,162,856

G

peroxiredoxin 5

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of PRDX5 mRNA

NCBI chr 1:213,529,042...213,532,787
Ensembl chr 1:204,099,826...204,114,268

G

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1

multiple interactions
decreases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of PREX1 mRNA
lanthanum chloride results in decreased expression of PREX1 mRNA

NCBI chr 3:175,724,939...175,875,764
Ensembl chr 3:155,306,950...155,456,688

G

peroxidasin

multiple interactions
decreases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of PXDN mRNA
lanthanum chloride results in decreased expression of PXDN mRNA

NCBI chr 6:52,308,347...52,385,943
Ensembl chr 6:46,580,761...46,658,345

G

glycogen phosphorylase B

decreases expression

EXP

lanthanum chloride results in decreased expression of PYGB mRNA; lanthanum chloride results in decreased expression of PYGB protein

NCBI chr 3:160,072,141...160,118,930
Ensembl chr 3:139,611,749...139,663,553

G

RAB7A, member RAS oncogene family

increases expression

EXP

lanthanum chloride results in increased expression of RAB7A protein

NCBI chr 4:122,019,281...122,068,067
Ensembl chr 4:120,461,963...120,506,889

G

RAD51 recombinase

multiple interactions

ISO

[lanthanum chloride co-treated with Cisplatin] results in increased expression of RAD51 protein

NCBI chr 3:126,554,210...126,578,888
Ensembl chr 3:106,100,381...106,125,035

G

regulator of microtubule dynamics 3

decreases expression

EXP

lanthanum chloride results in decreased expression of RMDN3 protein

NCBI chr 3:126,579,811...126,601,016
Ensembl chr 3:106,125,951...106,146,586

G

scavenger receptor class A, member 3

increases expression

ISO

lanthanum chloride results in increased expression of SCARA3 mRNA

NCBI chr15:44,315,422...44,348,416
Ensembl chr15:40,140,161...40,172,894

G

selenoprotein P

multiple interactions
increases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of SELENOP mRNA
lanthanum chloride results in increased expression of SELENOP mRNA

NCBI chr 2:54,225,736...54,236,022
Ensembl chr 2:52,498,339...52,508,852

G

sirtuin 2

multiple interactions
increases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of SIRT2 mRNA
lanthanum chloride results in increased expression of SIRT2 mRNA

NCBI chr 1:93,181,472...93,204,499
Ensembl chr 1:84,052,903...84,076,975

G

solute carrier family 16 member 1

decreases expression

EXP

lanthanum chloride results in decreased expression of SLC16A1 mRNA; lanthanum chloride results in decreased expression of SLC16A1 protein

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:192,124,289...192,144,611

G

solute carrier family 16 member 3

decreases expression

EXP

lanthanum chloride results in decreased expression of SLC16A3 mRNA; lanthanum chloride results in decreased expression of SLC16A3 protein

NCBI chr10:106,712,328...106,756,168
Ensembl chr10:106,212,778...106,222,562

G

solute carrier family 16 member 7

decreases expression

EXP

lanthanum chloride results in decreased expression of SLC16A7 mRNA; lanthanum chloride results in decreased expression of SLC16A7 protein

NCBI chr 7:62,929,067...63,096,995
Ensembl chr 7:61,051,167...61,154,994

G

solute carrier family 1 member 2

decreases expression

EXP

lanthanum chloride results in decreased expression of SLC1A2

NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:89,005,129...89,126,498

G

solute carrier family 1 member 3

decreases expression

EXP

lanthanum chloride results in decreased expression of SLC1A3

NCBI chr 2:59,482,707...59,557,808
Ensembl chr 2:57,755,497...57,830,605

G

solute carrier family 2 member 1

decreases expression

EXP

lanthanum chloride results in decreased expression of SLC2A1 mRNA; lanthanum chloride results in decreased expression of SLC2A1 protein

NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:132,717,196...132,745,416

G

superoxide dismutase 2

multiple interactions
increases expression

ISO

[cerous chloride co-treated with lanthanum chloride] results in increased expression of SOD2 mRNA
lanthanum chloride results in increased expression of SOD2 mRNA

NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189

G

sequestosome 1

multiple interactions
decreases expression

ISO
EXP

[cerous chloride co-treated with lanthanum chloride] results in increased expression of SQSTM1 mRNA
lanthanum chloride results in decreased expression of SQSTM1 protein

PMID:28954213 PMID:35090998

NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673

G

sulfiredoxin 1

increases expression
multiple interactions

ISO

lanthanum chloride results in increased expression of SRXN1 mRNA
[cerous chloride co-treated with lanthanum chloride] results in increased expression of SRXN1 mRNA

NCBI chr 3:161,064,812...161,070,372
Ensembl chr 3:140,599,608...140,628,448

G

serine/threonine kinase 25

multiple interactions

ISO

[cerous chloride co-treated with lanthanum chloride] results in decreased expression of STK25 mRNA

NCBI chr 9:101,609,218...101,621,458
Ensembl chr 9:94,161,836...94,174,244

G

syntaxin 17

increases expression

EXP

lanthanum chloride results in increased expression of STX17 protein

NCBI chr 5:67,241,673...67,302,228
Ensembl chr 5:62,446,187...62,504,451

G

uncoupling protein 2

decreases expression
multiple interactions

ISO

lanthanum chloride results in decreased expression of UCP2 mRNA
[cerous chloride co-treated with lanthanum chloride] affects the expression of UCP2 mRNA

NCBI chr 1:164,251,373...164,257,742
Ensembl chr 1:154,839,209...154,845,611

G

unc-51 like autophagy activating kinase 1

increases expression
decreases expression

EXP

lanthanum chloride results in increased expression of ULK1 protein
lanthanum chloride results in decreased expression of ULK1 protein modified form

NCBI chr12:51,511,492...51,537,746
Ensembl chr12:45,851,710...45,877,966

G

VAMP associated protein B and C

decreases expression

EXP

lanthanum chloride results in decreased expression of VAPB protein

NCBI chr 3:182,954,247...182,997,018
Ensembl chr 3:162,535,905...162,573,763

motexafin gadolinium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amylo-alpha-1,6-glucosidase and 4-alpha-glucanotransferase

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of AGL mRNA
motexafin gadolinium results in decreased expression of AGL mRNA

NCBI chr 2:204,705,053...204,760,966
Ensembl chr 2:204,705,053...204,760,828

G

aldehyde dehydrogenase 5 family, member A1

multiple interactions
increases expression

ISO

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of ALDH5A1 mRNA]
motexafin gadolinium results in increased expression of ALDH5A1 mRNA

NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677

G

aldehyde dehydrogenase 6 family, member A1

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of ALDH6A1 mRNA
Zinc Acetate inhibits the reaction [motexafin gadolinium results in decreased expression of ALDH6A1 mRNA]

NCBI chr 6:109,809,092...109,829,725
Ensembl chr 6:104,077,979...104,098,656

G

Rho GTPase activating protein 17

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of ARHGAP17 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ARHGAP17 mRNA

NCBI chr 1:177,807,579...177,897,027
Ensembl chr 1:177,807,583...177,896,854

G

activating transcription factor 3

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of ATF3 mRNA]
motexafin gadolinium results in increased expression of ATF3 mRNA

NCBI chr13:105,274,103...105,331,653
Ensembl chr13:102,751,321...102,764,631

G

ATM serine/threonine kinase

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of ATM mRNA]
motexafin gadolinium results in increased expression of ATM mRNA

NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437

G

ATR serine/threonine kinase

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of ATR mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ATR mRNA

NCBI chr 8:105,306,299...105,403,742
Ensembl chr 8:96,426,724...96,524,136

G

BTB domain and CNC homolog 1

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of BACH1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BACH1 mRNA

NCBI chr11:26,939,429...26,974,876
Ensembl chr11:26,939,480...26,972,447

G

BAG cochaperone 3

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of BAG3 mRNA]
motexafin gadolinium results in increased expression of BAG3 mRNA

NCBI chr 1:183,103,038...183,126,862
Ensembl chr 1:183,102,871...183,126,858

G

Bcl-2 binding component 3

multiple interactions

ISO

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of BBC3 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of BBC3 protein]

NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509

G

baculoviral IAP repeat-containing 5

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of BIRC5 mRNA]
motexafin gadolinium results in increased expression of BIRC5 mRNA

NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380

G

BCL2 interacting protein 3

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of BNIP3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3 mRNA

NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359

G

BCL2 interacting protein 3 like

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of BNIP3L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of BNIP3L mRNA

NCBI chr15:45,350,081...45,373,213
Ensembl chr15:41,174,594...41,197,803

G

calnexin

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of CANX mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CANX mRNA

NCBI chr10:35,124,941...35,157,954
Ensembl chr10:34,625,191...34,656,821

G

caspase 3

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of CASP3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CASP3 mRNA

NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648

G

core-binding factor subunit beta

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of CBFB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CBFB mRNA

NCBI chr19:49,955,133...50,002,661
Ensembl chr19:33,049,172...33,092,751

G

cyclin J

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CCNJ mRNA
motexafin gadolinium results in decreased expression of CCNJ mRNA

NCBI chr 1:239,659,588...239,677,367

G

cell division cycle 16

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of CDC16 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDC16 mRNA

NCBI chr16:82,475,234...82,498,797
Ensembl chr16:75,773,028...75,796,550

G

cell division cycle 25C

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of CDC25C mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDC25C mRNA

NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,335,834...26,356,185

G

cell division cycle 27

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of CDC27 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of CDC27 mRNA

NCBI chr10:89,400,720...89,449,816
Ensembl chr10:89,400,940...89,449,736

G

cell division cycle 5-like

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of CDC5L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDC5L mRNA

NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450

G

cell division cycle associated 2

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of CDCA2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDCA2 mRNA

NCBI chr15:46,071,360...46,117,524
Ensembl chr15:41,895,901...41,941,611

G

cyclin-dependent kinase 19

increases expression

ISO

motexafin gadolinium results in increased expression of CDK19 mRNA

NCBI chr20:43,770,409...43,910,629
Ensembl chr20:43,770,409...43,910,628

G

cyclin dependent kinase 2

multiple interactions
increases expression

ISO

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of CDK2 mRNA]
motexafin gadolinium results in increased expression of CDK2 mRNA

NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

ISO

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CDKN1A mRNA]

NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of CDKN1B mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CDKN1B mRNA

NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982

G

cystathionine gamma-lyase

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of CTH mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CTH mRNA

NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234

G

cullin 3

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of CUL3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of CUL3 mRNA

NCBI chr 9:89,040,987...89,118,775
Ensembl chr 9:81,592,641...81,670,462

G

cytochrome b5 reductase 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of CYB5R1 mRNA
motexafin gadolinium results in increased expression of CYB5R1 mRNA

NCBI chr13:45,849,017...45,855,458
Ensembl chr13:45,849,091...45,855,458

G

death-associated protein kinase 3

multiple interactions
decreases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DAPK3 mRNA]
motexafin gadolinium results in decreased expression of DAPK3 mRNA

NCBI chr 7:8,524,182...8,532,552
Ensembl chr 7:8,524,183...8,532,558

G

DNA-damage inducible transcript 3

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DDIT3 mRNA]
motexafin gadolinium results in increased expression of DDIT3 mRNA

NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201

G

DNA-damage-inducible transcript 4

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of DDIT4 mRNA
motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of DDIT4 mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of DDIT4 mRNA]

NCBI chr20:28,434,938...28,437,037
Ensembl chr20:27,891,998...27,894,105

G

death effector domain containing 2

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of DEDD2 mRNA]
motexafin gadolinium results in increased expression of DEDD2 mRNA

NCBI chr 1:80,789,084...80,807,789
Ensembl chr 1:80,792,000...80,807,714

G

DNA fragmentation factor subunit beta

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of DFFB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of DFFB mRNA

NCBI chr 5:164,522,446...164,534,733
Ensembl chr 5:164,522,463...164,534,628

G

7-dehydrocholesterol reductase

decreases expression

ISO

motexafin gadolinium results in decreased expression of DHCR7 mRNA

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

DnaJ heat shock protein family (Hsp40) member B1

multiple interactions
increases expression

ISO

motexafin gadolinium inhibits the reaction [Zinc Acetate results in decreased expression of DNAJB1 mRNA]
motexafin gadolinium results in increased expression of DNAJB1 mRNA

NCBI chr19:41,427,453...41,431,141
Ensembl chr19:24,522,717...24,526,458

G

DnaJ heat shock protein family (Hsp40) member B4

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of DNAJB4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of DNAJB4 mRNA

NCBI chr 2:241,129,346...241,159,272
Ensembl chr 2:241,130,340...241,159,089

G

DnaJ heat shock protein family (Hsp40) member B6

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of DNAJB6 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of DNAJB6 mRNA

NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659

G

DnaJ heat shock protein family (Hsp40) member C3

multiple interactions
increases expression

ISO

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of DNAJC3 mRNA]
motexafin gadolinium results in increased expression of DNAJC3 mRNA

NCBI chr15:102,432,667...102,475,643
Ensembl chr15:96,025,624...96,065,181

G

E2F transcription factor 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F1 mRNA
motexafin gadolinium results in increased expression of E2F1 mRNA

NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361

G

E2F transcription factor 3

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of E2F3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of E2F3 mRNA

NCBI chr17:34,601,756...34,679,139
Ensembl chr17:34,601,830...34,676,253

G

egl-9 family hypoxia-inducible factor 1

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of EGLN1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of EGLN1 mRNA

NCBI chr19:69,765,276...69,804,681
Ensembl chr19:52,869,486...52,907,777

G

elongator acetyltransferase complex subunit 1

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of ELP1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of ELP1 mRNA

NCBI chr 5:71,453,338...71,505,833
Ensembl chr 5:71,456,310...71,505,762

G

enolase 1

increases expression

ISO

motexafin gadolinium results in increased expression of ENO1 mRNA

NCBI chr 5:166,002,867...166,014,252
Ensembl chr 5:160,719,951...160,731,336
Ensembl chr 3:160,719,951...160,731,336

G

Fas associated via death domain

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of FADD mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FADD mRNA

NCBI chr 1:209,169,245...209,175,423
Ensembl chr 1:199,739,994...199,745,653

G

Fas apoptotic inhibitory molecule

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of FAIM mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of FAIM mRNA

NCBI chr 8:99,543,877...99,569,499
Ensembl chr 8:99,542,405...99,560,562

G

family with sequence similarity 162, member A

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of FAM162A mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FAM162A mRNA

NCBI chr11:64,680,978...64,709,865
Ensembl chr11:64,680,323...64,711,239

G

fatty acid synthase

decreases expression

ISO

motexafin gadolinium results in decreased expression of FASN mRNA

NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261

G

forkhead box O3

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of FOXO3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of FOXO3 mRNA

NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561

G

glutamate cysteine ligase, modifier subunit

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GCLM mRNA
motexafin gadolinium results in increased expression of GCLM mRNA

NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535

G

glutaminase

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of GLS mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GLS mRNA

NCBI chr 9:56,836,584...56,908,861
Ensembl chr 9:49,344,781...49,416,900

G

G protein-coupled receptor 146

increases expression

ISO

motexafin gadolinium results in increased expression of GPR146 mRNA

NCBI chr12:15,251,936...15,267,217
Ensembl chr12:15,251,813...15,267,206

G

glutamic--pyruvic transaminase 2

increases expression

ISO

motexafin gadolinium results in increased expression of GPT2 mRNA

NCBI chr19:21,526,800...21,561,314
Ensembl chr19:21,517,621...21,560,610

G

glutathione peroxidase 1

multiple interactions

ISO

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of GPX1 mRNA]

NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024

G

glutathione-disulfide reductase

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of GSR mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of GSR mRNA

NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661

G

general transcription factor IIIC subunit 2

increases expression

ISO

motexafin gadolinium results in increased expression of GTF3C2 mRNA

NCBI chr 6:25,196,439...25,221,338
Ensembl chr 6:25,197,268...25,220,490

G

HMG-box transcription factor 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HBP1 mRNA
motexafin gadolinium results in increased expression of HBP1 mRNA

NCBI chr 6:54,257,118...54,283,373
Ensembl chr 6:48,529,372...48,555,787

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

ISO

[motexafin gadolinium co-treated with Zinc Acetate] results in increased expression of HIF1A protein
motexafin gadolinium results in increased expression of HIF1A protein

NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261

G

hypoxia inducible lipid droplet-associated

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of HILPDA mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HILPDA mRNA

NCBI chr 4:57,871,088...57,874,048
Ensembl chr 4:57,871,110...57,874,557

G

homeodomain interacting protein kinase 1

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HIPK1 mRNA]
motexafin gadolinium results in increased expression of HIPK1 mRNA

NCBI chr 2:193,937,261...193,988,247
Ensembl chr 2:191,248,817...191,298,902

G

helicase-like transcription factor

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of HLTF mRNA
motexafin gadolinium results in decreased expression of HLTF mRNA

NCBI chr 2:102,549,724...102,609,492
Ensembl chr 2:102,549,724...102,609,327

G

heme oxygenase 1

multiple interactions
increases expression

ISO

[motexafin gadolinium co-treated with Zinc Acetate] results in increased expression of HMOX1 protein; motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HMOX1 mRNA]
motexafin gadolinium results in increased expression of HMOX1 mRNA

NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079

G

harakiri, BCL2 interacting protein

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HRK mRNA
motexafin gadolinium results in increased expression of HRK mRNA

NCBI chr12:44,048,402...44,070,561

G

heat shock protein 90 alpha family class B member 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSP90AB1 mRNA
motexafin gadolinium results in increased expression of HSP90AB1 mRNA

NCBI chr 9:22,930,249...22,935,929
Ensembl chr 9:15,433,691...15,438,488

G

heat shock protein family A (Hsp70) member 1A

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPA1A mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of HSPA1A mRNA]

NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227

G

heat shock protein family A (Hsp70) member 1B

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPA1B mRNA]; Zinc Acetate promotes the reaction [motexafin gadolinium results in increased expression of HSPA1B mRNA]

NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240

G

heat shock protein family A (Hsp70) member 4

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of HSPA4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSPA4 mRNA

NCBI chr10:37,908,866...37,951,994
Ensembl chr10:37,408,025...37,449,001

G

heat shock protein family A (Hsp70) member 4 like

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of HSPA4L mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of HSPA4L mRNA

NCBI chr 2:123,740,384...123,793,088
Ensembl chr 2:123,740,384...123,793,084

G

heat shock protein family B (small) member 1

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPB1 mRNA]
motexafin gadolinium results in increased expression of HSPB1 mRNA

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743

G

heat shock protein family D (Hsp60) member 1

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of HSPD1 mRNA]
motexafin gadolinium results in increased expression of HSPD1 mRNA

NCBI chr 9:64,073,610...64,084,332
Ensembl chr 9:56,579,201...56,589,662

G

heat shock protein family H (Hsp110) member 1

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of HSPH1 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of HSPH1 mRNA]

NCBI chr12:10,427,368...10,446,602
Ensembl chr12:5,390,922...5,410,224

G

inhibitor of DNA binding 2

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of ID2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of ID2 mRNA

NCBI chr 6:47,469,162...47,470,995
Ensembl chr 6:41,728,946...41,744,400

G

inhibitor of nuclear factor kappa B kinase subunit epsilon

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of IKBKE mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IKBKE mRNA

NCBI chr13:42,712,154...42,738,470
Ensembl chr13:42,712,159...42,737,143

G

interferon regulatory factor 2 binding protein 2

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of IRF2BP2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of IRF2BP2 mRNA

NCBI chr19:71,456,689...71,462,368
Ensembl chr19:54,560,128...54,566,642

G

JunD proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of JUND mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of JUND mRNA

NCBI chr16:18,768,093...18,769,771
Ensembl chr16:18,734,122...18,735,799

G

lysine demethylase 3A

increases expression

ISO

motexafin gadolinium results in increased expression of KDM3A mRNA

NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073

G

MDM2 proto-oncogene

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of MDM2 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MDM2 mRNA]

NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915

G

MOB kinase activator 1A

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of MOB1A mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of MOB1A mRNA]

NCBI chr 4:115,831,581...115,848,561
Ensembl chr 4:115,831,551...115,848,561
Ensembl chr 1:115,831,551...115,848,561

G

metallothionein 1

multiple interactions

ISO

[Zinc co-treated with motexafin gadolinium] results in increased expression of MT1A mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049
Ensembl chr X:10,826,032...10,827,049

G

metallothionein 1, pseudogene 3

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of MT1E mRNA
motexafin gadolinium results in increased expression of MT1E mRNA

PMID:15867382 PMID:16357179

NCBI chr17:79,695,812...79,696,200
Ensembl chr17:74,786,654...74,787,135

G

metallothionein 2

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT2A mRNA]
motexafin gadolinium results in increased expression of MT2A mRNA

PMID:15867382 PMID:16357179

NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784

G

metallothionein 2, pseudogene 1

multiple interactions
increases expression

ISO

motexafin gadolinium promotes the reaction [Zinc Acetate results in increased expression of MT1HL1 mRNA]
motexafin gadolinium results in increased expression of MT1HL1 mRNA

PMID:15867382 PMID:16357179

NCBI chr20:3,159,037...3,159,409
Ensembl chr 5:119,728,811...119,730,073

G

MYD88, innate immune signal transduction adaptor

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of MYD88 mRNA
motexafin gadolinium results in decreased expression of MYD88 mRNA

NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415

G

NAD kinase

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of NADK mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NADK mRNA

NCBI chr 5:166,145,708...166,176,328
Ensembl chr 5:166,145,481...166,176,322

G

neurofibromin 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of NF1 mRNA
motexafin gadolinium results in increased expression of NF1 mRNA

NCBI chr10:64,803,986...65,037,086
Ensembl chr10:64,306,301...64,536,658

G

nischarin

decreases expression

ISO

motexafin gadolinium results in decreased expression of NISCH mRNA

NCBI chr16:6,364,370...6,400,675
Ensembl chr16:6,364,374...6,400,668

G

nuclear receptor subfamily 1, group D, member 2

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of NR1D2 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of NR1D2 mRNA]

NCBI chr15:9,955,034...9,981,329
Ensembl chr15:7,524,257...7,550,553

G

prolyl 4-hydroxylase subunit beta

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of P4HB mRNA]
motexafin gadolinium results in increased expression of P4HB mRNA

NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500

G

programmed cell death 11

decreases expression

ISO

motexafin gadolinium results in decreased expression of PDCD11 mRNA

NCBI chr 1:245,980,840...246,021,999
Ensembl chr 1:245,980,880...246,021,999

G

programmed cell death 4

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of PDCD4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PDCD4 mRNA

NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:252,921,392...252,944,275

G

programmed cell death 5

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of PDCD5 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PDCD5 mRNA

NCBI chr 1:88,305,869...88,311,200
Ensembl chr 1:88,305,869...88,311,200

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of PFKFB3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB3 mRNA

NCBI chr17:66,983,629...67,064,702
Ensembl chr17:66,983,686...67,063,125

G

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of PFKFB4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PFKFB4 mRNA

NCBI chr 8:109,643,558...109,687,006
Ensembl chr 8:109,643,937...109,685,634

G

phosphoglycerate kinase 1

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of PGK1 mRNA
motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PGK1 mRNA]

NCBI chr X:75,336,988...75,352,962
Ensembl chr X:71,271,440...71,287,418

G

putative homeodomain transcription factor 2

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PHTF2 mRNA]
motexafin gadolinium results in increased expression of PHTF2 mRNA

NCBI chr 4:14,215,190...14,330,549
Ensembl chr 4:14,215,263...14,330,513

G

protein inhibitor of activated STAT, 1

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of PIAS1 mRNA]
motexafin gadolinium results in increased expression of PIAS1 mRNA

NCBI chr 8:72,233,566...72,347,085
Ensembl chr 8:63,338,150...63,438,905

G

phosphoinositide-3-kinase interacting protein 1

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of PIK3IP1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PIK3IP1 mRNA

NCBI chr14:82,428,315...82,440,261
Ensembl chr14:78,204,053...78,216,608

G

phorbol-12-myristate-13-acetate-induced protein 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PMAIP1 mRNA
motexafin gadolinium results in increased expression of PMAIP1 mRNA

NCBI chr18:62,255,970...62,262,384
Ensembl chr18:59,986,017...59,992,429

G

protein kinase cAMP-activated catalytic subunit beta

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of PRKACB mRNA
motexafin gadolinium results in increased expression of PRKACB mRNA

NCBI chr 2:238,297,140...238,389,317
Ensembl chr 2:235,636,885...235,726,198

G

protein kinase C, delta

decreases expression

ISO

motexafin gadolinium results in decreased expression of PRKCD mRNA

NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352

G

protein kinase D2

decreases expression

ISO

motexafin gadolinium results in decreased expression of PRKD2 mRNA

NCBI chr 1:86,640,095...86,670,476
Ensembl chr 1:77,513,986...77,542,376

G

protein kinase, DNA-activated, catalytic subunit

increases expression

ISO

motexafin gadolinium results in increased expression of PRKDC mRNA

NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952

G

peptidyl-tRNA hydrolase 2

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of PTRH2 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of PTRH2 mRNA

NCBI chr10:71,505,113...71,515,297
Ensembl chr10:71,504,956...71,515,398

G

RB transcriptional corepressor 1

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of RB1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of RB1 mRNA

NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302

G

RCC1 and BTB domain containing protein 2

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of RCBTB2 mRNA
motexafin gadolinium results in decreased expression of RCBTB2 mRNA

NCBI chr15:48,319,809...48,364,441
Ensembl chr15:48,323,866...48,383,750

G

RELB proto-oncogene, NF-kB subunit

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of RELB mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of RELB mRNA

NCBI chr 1:88,385,717...88,413,380
Ensembl chr 1:79,257,725...79,285,507

G

ring finger protein 19B

increases expression

ISO

motexafin gadolinium results in increased expression of RNF19B mRNA

NCBI chr 5:141,406,085...141,431,376
Ensembl chr 5:141,406,118...141,431,380

G

S-adenosylmethionine sensor upstream of mTORC1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SAMTOR mRNA
motexafin gadolinium results in increased expression of SAMTOR mRNA

NCBI chr 4:41,881,630...41,945,472
Ensembl chr 4:41,879,993...41,945,539

G

selenoprotein W

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SELENOW mRNA
motexafin gadolinium results in increased expression of SELENOW mRNA

NCBI chr 1:76,599,441...76,604,514
Ensembl chr 1:76,598,779...76,604,724
Ensembl chr 1:76,598,779...76,604,724

G

sestrin 2

multiple interactions
increases expression

ISO

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA; [Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SESN2 mRNA; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SESN2 mRNA]
motexafin gadolinium results in increased expression of SESN2 mRNA

PMID:16357179 PMID:20530418

NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260

G

solute carrier family 16 member 1

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC16A1 mRNA]
motexafin gadolinium results in increased expression of SLC16A1 mRNA

NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:192,124,289...192,144,611

G

solute carrier family 16, member 6

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC16A6 mRNA
motexafin gadolinium results in increased expression of SLC16A6 mRNA

NCBI chr10:94,923,888...94,946,990
Ensembl chr10:94,426,244...94,448,779

G

solute carrier family 1 member 4

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC1A4 mRNA]
motexafin gadolinium results in increased expression of SLC1A4 mRNA

NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418

G

solute carrier family 30 member 1

multiple interactions
increases expression

ISO

[Zinc co-treated with motexafin gadolinium] results in increased expression of SLC30A1 mRNA; motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC30A1 mRNA]; Zinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC30A1 mRNA]

PMID:15867382 PMID:16357179

NCBI chr13:106,022,019...106,025,892
Ensembl chr13:103,491,037...103,494,910

G

solute carrier family 38, member 2

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of SLC38A2 mRNA]; Zinc Acetate affects the reaction [motexafin gadolinium results in increased expression of SLC38A2 mRNA]

NCBI chr 7:129,730,450...129,742,619
Ensembl chr 7:127,851,267...127,863,436

G

solute carrier family 39 member 10

multiple interactions
affects expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC39A10 mRNA
motexafin gadolinium affects the expression of SLC39A10 mRNA

NCBI chr 9:62,331,281...62,454,754
Ensembl chr 9:54,876,141...54,960,325

G

solute carrier family 39 member 14

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of SLC39A14 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC39A14 mRNA

NCBI chr15:51,786,517...51,833,260
Ensembl chr15:45,376,917...45,423,524

G

solute carrier family 39, member 9

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of SLC39A9 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC39A9 mRNA

NCBI chr 6:106,022,858...106,061,734
Ensembl chr 6:100,291,573...100,330,408

G

solute carrier family 3 member 2

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC3A2 mRNA
motexafin gadolinium results in increased expression of SLC3A2 mRNA

NCBI chr 1:215,033,601...215,048,064
Ensembl chr 1:205,604,468...205,618,931

G

solute carrier family 43 member 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of SLC43A1 mRNA
motexafin gadolinium results in increased expression of SLC43A1 mRNA

NCBI chr 3:90,327,250...90,353,438
Ensembl chr 3:69,920,649...69,946,768

G

solute carrier family 7 member 1

multiple interactions
increases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A1 mRNA
motexafin gadolinium results in increased expression of SLC7A1 mRNA

NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849

G

solute carrier family 7 member 11

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of SLC7A11 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of SLC7A11 mRNA

NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536

G

SWI/SNF related BAF chromatin remodeling complex subunit ATPase 4

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of SMARCA4 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA4 mRNA

NCBI chr 8:20,167,717...20,258,975
Ensembl chr 8:20,167,717...20,258,975

G

SNF2 related chromatin remodeling ATPase 5

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of SMARCA5 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of SMARCA5 mRNA

NCBI chr19:27,271,918...27,304,594
Ensembl chr19:27,271,148...27,304,594

G

T-cell activation RhoGTPase activating protein

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of TAGAP mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TAGAP mRNA

NCBI chr 1:47,170,725...47,179,705
Ensembl chr 1:47,170,725...47,179,792

G

transferrin receptor

multiple interactions
increases expression

ISO

motexafin gadolinium affects the reaction [Zinc Acetate results in increased expression of TFRC mRNA]
motexafin gadolinium results in increased expression of TFRC mRNA

NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257

G

TNF alpha induced protein 8

decreases expression
multiple interactions

ISO

motexafin gadolinium results in decreased expression of TNFAIP8 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFAIP8 mRNA

NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517

G

TNF receptor superfamily member 17

multiple interactions
decreases expression

ISO

[Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TNFRSF17 mRNA
motexafin gadolinium results in decreased expression of TNFRSF17 mRNA

NCBI chr10:4,301,023...4,306,889
Ensembl chr10:4,301,038...4,306,788

G

TNF receptor superfamily member 1A

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of TNFRSF1A mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TNFRSF1A mRNA

NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591

G

TNF superfamily member 8

multiple interactions
increases expression

ISO

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of TNFSF8 mRNA]
motexafin gadolinium results in increased expression of TNFSF8 mRNA

NCBI chr 5:82,266,436...82,292,858
Ensembl chr 5:77,251,373...77,277,421

G

TNFAIP3 interacting protein 2

decreases expression

ISO

motexafin gadolinium results in decreased expression of TNIP2 mRNA

NCBI chr14:76,228,350...76,245,553
Ensembl chr14:76,228,371...76,275,265

G

tumor protein p53

multiple interactions

ISO

[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein; Acetylcysteine inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]; nutlin 3 inhibits the reaction [[Ascorbic Acid co-treated with Zinc Acetate co-treated with motexafin gadolinium] results in decreased expression of TP53 protein]

NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524

G

tribbles pseudokinase 3

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of TRIB3 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TRIB3 mRNA

NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:140,809,043...140,814,497

G

thioredoxin reductase 1

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of TXNRD1 mRNA
[Zinc Acetate co-treated with motexafin gadolinium] results in increased expression of TXNRD1 mRNA

NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863

G

vascular endothelial growth factor A

increases expression
multiple interactions

ISO

motexafin gadolinium results in increased expression of VEGFA mRNA
[Zinc Acetate co-treated with motexafin gadolinium] affects the expression of VEGFA mRNA

NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641

G

von Hippel-Lindau tumor suppressor

multiple interactions
increases expression

ISO

motexafin gadolinium inhibits the reaction [Zinc Acetate results in increased expression of VHL mRNA]
motexafin gadolinium results in increased expression of VHL mRNA

NCBI chr 4:146,772,483...146,779,376
Ensembl chr 4:146,772,468...146,779,377

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calcium voltage-gated channel subunit alpha1 G

multiple interactions

ISO

Neodymium inhibits the reaction [CACNA1G protein results in increased transport of Barium]

NCBI chr10:79,851,886...79,919,926
Ensembl chr10:79,355,008...79,422,752

G

heat shock protein family B (small) member 1

decreases phosphorylation
increases expression

ISO

Neodymium results in decreased phosphorylation of HSPB1 protein
Neodymium results in increased expression of HSPB1 mRNA; Neodymium results in increased expression of HSPB1 protein

NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743

G

proteasome 20S subunit beta 2

decreases expression

ISO

Neodymium results in decreased expression of PSMB2 protein

NCBI chr 5:138,970,564...139,002,715
Ensembl chr 5:138,970,533...139,021,137

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

increases expression

ISO

Ytterbium analog results in increased expression of BAX protein

NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368

G

BCL2, apoptosis regulator

decreases expression

ISO

Ytterbium analog results in decreased expression of BCL2 protein

NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

calcium voltage-gated channel subunit alpha1 G

multiple interactions

ISO

Ytterbium inhibits the reaction [CACNA1G protein results in increased transport of Barium]

NCBI chr10:79,851,886...79,919,926
Ensembl chr10:79,355,008...79,422,752

G

caspase 9

increases activity

ISO

Ytterbium analog results in increased activity of CASP9 protein

Ensembl chr 5:154,109,046...154,126,626

G

poly (ADP-ribose) polymerase 1

increases cleavage

ISO

Ytterbium analog results in increased cleavage of PARP1 protein

NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	20856
chemical entity	20854
atom	20854
metal atom	18400
transition element atom	17941
rare earth metal atom	445
lanthanoid atom	443
cerium +	195
dysprosium atom +	0
erbium +	1
europium atom +	0
gadolinium atom +	258
holmium atom +	1
lanthanoid molecular entity +	415
lanthanum atom +	102
lutetium atom +	0
neodymium atom +	3
praseodymium atom +	0
promethium atom +	0
samarium atom +	0
terbium atom +	0
thulium atom +	0
ytterbium +	5
Path 2
Term	Annotations
CHEBI ontology	20856
subatomic particle	20854
composite particle	20854
hadron	20854
baryon	20854
nucleon	20854
atomic nucleus	20854
atom	20854
metal atom	18400
transition element atom	17941
rare earth metal atom	445
lanthanoid atom	443
cerium +	195
dysprosium atom +	0
erbium +	1
europium atom +	0
gadolinium atom +	258
holmium atom +	1
lanthanoid molecular entity +	415
lanthanum atom +	102
lutetium atom +	0
neodymium atom +	3
praseodymium atom +	0
promethium atom +	0
samarium atom +	0
terbium atom +	0
thulium atom +	0
ytterbium +	5

paths to the root