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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:chalcogen
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Accession:CHEBI:33303 term browser browse the term
Definition:Any p-block element belonging to the group 16 family of the periodic table.
Synonyms:exact_synonym: chalcogens
 related_synonym: Chalkogen;   Chalkogene;   anfigeno;   anfigenos;   calcogeno;   calcogenos;   chalcogene;   chalcogenes;   group 16 elements;   group VI elements
 xref: PMID:17084588


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(+)-artemisinin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity
multiple interactions		 EXP artemisinin results in increased activity of NR1I3 protein; artemisinin results in increased activity of NR1I3 protein alternative form; artemisinin results in increased activity of NR1I3 protein mutant form
androstan-3-ol inhibits the reaction [artemisinin results in increased activity of NR1I3 protein mutant form]; artemisinin inhibits the reaction [androstan-3-ol results in decreased activity of NR1I3 protein alternative form]; artemisinin inhibits the reaction [Imidazoles results in decreased activity of NR1I3 protein alternative form]; Imidazoles inhibits the reaction [artemisinin results in increased activity of NR1I3 protein mutant form]		 CTD PMID:21778469 PMID:27732639 NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827 		JBrowse link
(R)-adrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NPPA natriuretic peptide A affects abundance EXP NPPA protein affects the abundance of Epinephrine CTD PMID:2951327 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385 		JBrowse link
(R)-noradrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 increases activity EXP Norepinephrine results in increased activity of ADRB1 protein CTD PMID:10344530 NCBI chr28:24,908,224...24,909,684
Ensembl chr28:24,908,224...24,909,684 		JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP [Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine CTD PMID:2884805 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298 		JBrowse link
G NPPA natriuretic peptide A increases expression EXP Norepinephrine results in increased expression of NPPA protein CTD PMID:8952593 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions
increases activity		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of PIK3CG protein]; [Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G POMC proopiomelanocortin increases response to substance EXP POMC protein results in increased susceptibility to Norepinephrine CTD PMID:6279499 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440 		JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
G REN renin increases activity EXP Norepinephrine results in increased activity of REN protein CTD PMID:8952593 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 decreases activity
multiple interactions		 EXP 1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein
dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]		 CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
1,4-dithiothreitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Dithiothreitol metabolite results in increased expression of HSPA5 protein CTD PMID:17416481 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257 		JBrowse link
1-stearoyl-2-arachidonoylphosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP 1-stearoyl-2-arachidonoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
15-deoxy-Delta(12,14)-prostaglandin J2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HIF1A hypoxia inducible factor 1 subunit alpha increases expression EXP 15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of HIF1A protein CTD PMID:17658243 NCBI chr 8:36,614,045...36,656,692
Ensembl chr 8:36,614,045...36,656,692 		JBrowse link
16-Ketoestrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPNE6 copine 6 increases reduction EXP DHRS4 protein results in increased reduction of 16-ketoestrone CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
17beta-estradiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 protein affects the transport of Estradiol CTD PMID:15507541 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740 		JBrowse link
G ESR1 estrogen receptor 1 affects expression EXP Estradiol affects the expression of ESR1 protein CTD PMID:16483645 NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544 		JBrowse link
17beta-estradiol 17-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B2 solute carrier organic anion transporter family member 1B2 increases transport EXP SLCO1B3 protein results in increased transport of estradiol-17 beta-glucuronide CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989 		JBrowse link
17beta-hydroxy-5alpha-androstan-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOD2 superoxide dismutase 2 multiple interactions EXP Dihydrotestosterone promotes the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein] CTD PMID:16682413 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706 		JBrowse link
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP [Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin CTD PMID:20510202 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
2-hydroxypropanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCT secretin decreases abundance EXP SCT protein results in decreased abundance of Lactic Acid CTD PMID:2418308
2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOD1 superoxide dismutase 1 affects response to substance EXP SOD1 protein affects the susceptibility to Nafenopin CTD PMID:6333936 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815 		JBrowse link
3',5'-cyclic AMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions EXP [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059 		JBrowse link
3'-CMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions EXP [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate CTD PMID:2579070 NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653 		JBrowse link
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions EXP Cisapride binds to and results in decreased activity of KCNH2 protein CTD PMID:12388285 NCBI chr16:15,009,031...15,041,786
Ensembl chr16:15,009,031...15,041,504 		JBrowse link
4-nitrophenyl phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPI alkaline phosphatase, intestinal increases chemical synthesis EXP ALPI protein results in increased chemical synthesis of nitrophenylphosphate CTD PMID:1495895 NCBI chr25:44,107,418...44,110,947 JBrowse link
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions EXP pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059 		JBrowse link
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Omeprazole results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
G SLC22A6 solute carrier family 22 member 6 multiple interactions EXP [Omeprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr18:53,736,669...53,745,001
Ensembl chr18:53,736,959...53,744,396 		JBrowse link
5-Nitro-2-(3-phenylpropylamino)benzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator decreases activity EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CFTR protein CTD PMID:15496164 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977 		JBrowse link
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity EXP 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein mutant form CTD PMID:21778469 NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827 		JBrowse link
8-(4-chlorophenylthio)-cAMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator multiple interactions EXP [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein CTD PMID:15161604 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977 		JBrowse link
9-cis-retinal term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPNE6 copine 6 increases reduction EXP DHRS4 protein results in increased reduction of 9-cis-retinal CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
acenaphthoquinone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPNE6 copine 6 increases reduction EXP DHRS4 protein results in increased reduction of acenaphthenequinone CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
acetophenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPI alkaline phosphatase, intestinal increases chemical synthesis EXP ALPI protein results in increased chemical synthesis of acetophenone CTD PMID:1495895 NCBI chr25:44,107,418...44,110,947 JBrowse link
Acetyl tributyl citrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP 2-acetyltributylcitrate results in increased activity of NR1I2 protein CTD PMID:21742782 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
acetylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766 		JBrowse link
G KCNJ6 potassium inwardly rectifying channel subfamily J member 6 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions EXP Acetylcholine results in increased phosphorylation of and results in increased activity of MAPK14 protein CTD PMID:9688607 NCBI chr12:5,145,647...5,221,558
Ensembl chr12:5,146,037...5,220,603 		JBrowse link
acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Aspirin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
aldehydo-D-glucose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin decreases abundance
multiple interactions		 EXP INS protein results in decreased abundance of Glucose
[INS protein co-treated with Glucose] results in decreased abundance of Potassium; [INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin		 CTD PMID:140932 PMID:1013176 PMID:1646414 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
aldosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen increases abundance EXP AGT results in increased abundance of Aldosterone CTD PMID:2831029 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G POMC proopiomelanocortin increases abundance EXP POMC protein results in increased abundance of Aldosterone CTD PMID:2831029 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440 		JBrowse link
all-trans-retinoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity EXP Tretinoin results in increased activity of CASP3 protein CTD PMID:16953078 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505 		JBrowse link
G CLDN1 claudin 1 multiple interactions
increases expression		 EXP CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN1 mRNA]
Tretinoin results in increased expression of CLDN1 mRNA; Tretinoin results in increased expression of CLDN1 protein		 CTD PMID:17035595 NCBI chr34:22,303,058...22,319,101
Ensembl chr34:22,303,850...22,319,033 		JBrowse link
G CLDN4 claudin 4 increases expression
multiple interactions		 EXP Tretinoin results in increased expression of CLDN4 mRNA; Tretinoin results in increased expression of CLDN4 protein
CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN4 mRNA]		 CTD PMID:17035595 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
G CYP26A1 cytochrome P450 family 26 subfamily A member 1 increases degradation
multiple interactions		 EXP CYP26A1 protein results in increased degradation of Tretinoin
CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN1 mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN4 mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of OCLN mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of TJP1 mRNA]		 CTD PMID:17035595 NCBI chr28:7,423,955...7,432,359
Ensembl chr28:7,428,772...7,432,370 		JBrowse link
G NOS3 nitric oxide synthase 3 increases expression EXP Tretinoin results in increased expression of NOS3 mRNA; Tretinoin results in increased expression of NOS3 protein CTD PMID:17267746 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277 		JBrowse link
G OCLN occludin multiple interactions
increases expression		 EXP CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of OCLN mRNA]
Tretinoin results in increased expression of OCLN mRNA; Tretinoin results in increased expression of OCLN protein		 CTD PMID:17035595 NCBI chr 2:54,500,299...54,545,430
Ensembl chr 2:54,500,299...54,545,430 		JBrowse link
G TJP1 tight junction protein 1 increases expression
multiple interactions		 EXP Tretinoin results in increased expression of TJP1 mRNA; Tretinoin results in increased expression of TJP1 protein
CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of TJP1 mRNA]		 CTD PMID:17035595 NCBI chr 3:38,997,122...39,076,617
Ensembl chr 3:38,997,076...39,241,574 		JBrowse link
allicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP allicin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] CTD PMID:15266218 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
amiodarone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC8A1 solute carrier family 8 member A1 decreases activity EXP Amiodarone results in decreased activity of SLC8A1 protein CTD PMID:15288574 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700 		JBrowse link
amlodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin increases expression EXP Amlodipine results in increased expression of REN protein CTD PMID:10218729 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
amosulalol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 multiple interactions EXP amosulalol binds to and results in decreased activity of ADRB1 protein CTD PMID:6129981 NCBI chr28:24,908,224...24,909,684
Ensembl chr28:24,908,224...24,909,684 		JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP amosulalol binds to and results in decreased activity of ADRB2 protein CTD PMID:6129981 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298 		JBrowse link
amphotericin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL6 interleukin 6 multiple interactions
increases expression		 EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein] CTD PMID:24105867 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G PRKACB protein kinase cAMP-activated catalytic subunit beta increases expression
multiple interactions		 EXP Amphotericin B results in increased expression of PRKACG protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein]		 CTD PMID:24105867 NCBI chr 6:63,615,445...63,729,386
Ensembl chr 6:63,618,323...63,730,146 		JBrowse link
G REN renin decreases secretion EXP Amphotericin B results in decreased secretion of REN protein CTD PMID:7391978 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
G TNF tumor necrosis factor increases expression EXP Amphotericin B results in increased expression of TNF protein CTD PMID:24105867 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
anthra[1,9-cd]pyrazol-6(2H)-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions EXP pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]] CTD PMID:23816505 NCBI chr 5:50,966,698...50,968,939 JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119 		JBrowse link
G SP1 Sp1 transcription factor multiple interactions EXP pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein] CTD PMID:23816505 NCBI chr27:1,802,587...1,861,187
Ensembl chr27:1,805,184...1,847,226 		JBrowse link
antipyrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Antipyrine results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
arachidonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions EXP [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059 		JBrowse link
arsenite(3-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSP70 heat shock protein 70 increases expression
multiple interactions		 EXP arsenite results in increased expression of HSP70 mRNA
HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]		 CTD PMID:32899721 NCBI chr12:1,285,282...1,287,670 JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP arsenite affects the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]] CTD PMID:32899721 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]] CTD PMID:32899721 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]] CTD PMID:32899721 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] CTD PMID:32899721 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
arsenous acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:23236503 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:23236503 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G SLC9A1 solute carrier family 9 member A1 increases expression EXP Arsenic Trioxide results in increased expression of SLC9A1 protein CTD PMID:23236503 NCBI chr 2:73,054,742...73,103,364
Ensembl chr 2:73,054,742...73,103,364 		JBrowse link
atenolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin multiple interactions EXP Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] CTD PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702 		JBrowse link
G SCT secretin multiple interactions EXP Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates] CTD PMID:3562434
benazepril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DES desmin decreases expression EXP benazepril results in decreased expression of DES mRNA CTD PMID:20137276 NCBI chr37:25,933,525...25,939,910
Ensembl chr37:25,933,455...25,940,985 		JBrowse link
benzyl alcohol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 affects metabolic processing EXP CYP2E1 protein affects the metabolism of Benzyl Alcohol CTD PMID:8592870 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754 		JBrowse link
beta-naphthoflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 increases activity EXP beta-Naphthoflavone results in increased activity of CYP1A1 protein CTD PMID:3929785 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866 		JBrowse link
bis(2-ethylhexyl) phthalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity EXP Diethylhexyl Phthalate results in increased activity of NR1I3 protein CTD PMID:27732639 NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827 		JBrowse link
blebbistatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases localization EXP blebbistatin results in decreased localization of ABCB11 protein CTD PMID:15826951 NCBI chr36:13,742,895...13,835,312
Ensembl chr36:13,746,964...13,834,974 		JBrowse link
bromosulfophthalein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPNE6 copine 6 decreases activity EXP Sulfobromophthalein results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
G SLCO1B2 solute carrier organic anion transporter family member 1B2 increases transport EXP SLCO1B3 protein results in increased transport of Sulfobromophthalein CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989 		JBrowse link
Bufuralol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2D15 cytochrome P450 family 2 subfamily D member 15 affects metabolic processing EXP CYP2D6 protein affects the metabolism of bufuralol CTD PMID:15801540 NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298 		JBrowse link
calcein am term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 affects export EXP ABCC1 protein affects the export of calcein AM CTD PMID:12516967 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331 		JBrowse link
calcitriol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator affects expression EXP Calcitriol affects the expression of BCL2 protein CTD PMID:16080513 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658 		JBrowse link
calcium oxalate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions
increases activity		 EXP Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP3 protein] CTD PMID:25446497 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505 		JBrowse link
G CASP9 caspase 9 increases activity
multiple interactions		 EXP Calcium Oxalate results in increased activity of CASP9 protein
Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP9 protein]		 CTD PMID:25446497 NCBI chr 2:82,033,759...82,076,710
Ensembl chr 2:82,031,563...82,090,484 		JBrowse link
G TJP1 tight junction protein 1 multiple interactions
decreases expression		 EXP Docetaxel inhibits the reaction [Calcium Oxalate results in decreased expression of TJP1 protein]; Phalloidine inhibits the reaction [Calcium Oxalate results in decreased expression of TJP1 protein] CTD PMID:34147488 PMID:36349591 NCBI chr 3:38,997,122...39,076,617
Ensembl chr 3:38,997,076...39,241,574 		JBrowse link
cannabidiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL17 C-C motif chemokine ligand 17 multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of CCL17 promoter CTD PMID:33763461 NCBI chr 2:59,001,463...59,014,347
Ensembl chr 2:59,001,464...59,005,230 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of CCL2 promoter CTD PMID:33763461 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G IL13 interleukin 13 multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA] CTD PMID:33763461 NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388 		JBrowse link
G IL31 interleukin 31 multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA] CTD PMID:33763461 NCBI chr26:7,173,151...7,175,195
Ensembl chr26:7,172,451...7,175,195 		JBrowse link
G IL31RA interleukin 31 receptor A multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of IL31RA promoter CTD PMID:33763461 NCBI chr 2:43,113,194...43,198,200
Ensembl chr 2:43,144,071...43,193,293 		JBrowse link
G IL4 interleukin 4 multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA] CTD PMID:33763461 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G TSLP thymic stromal lymphopoietin multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of TSLP promoter CTD PMID:33763461 NCBI chr 3:1,502,469...1,507,696
Ensembl chr 3:1,503,188...1,507,696 		JBrowse link
capsaicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR1B 5-hydroxytryptamine receptor 1B multiple interactions EXP HTR1B protein promotes the reaction [donitriptan results in decreased susceptibility to Capsaicin] CTD PMID:16880765 NCBI chr12:38,659,088...38,659,546 JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions
increases activity		 EXP JYL 1421 inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein] CTD PMID:17392452 NCBI chr 9:47,404,987...47,443,871
Ensembl chr 9:47,404,972...47,431,926 		JBrowse link
carmustine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MGMT O-6-methylguanine-DNA methyltransferase decreases response to substance
multiple interactions		 EXP MGMT protein mutant form results in decreased susceptibility to Carmustine; MGMT protein results in decreased susceptibility to Carmustine
MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]		 CTD PMID:14617759 PMID:15053863 NCBI chr28:38,204,611...38,427,482
Ensembl chr28:38,204,610...38,427,380 		JBrowse link
carvacrol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSP70 heat shock protein 70 multiple interactions EXP carvacrol promotes the reaction [sodium arsenite results in increased expression of HSP70 protein] CTD PMID:31940135 NCBI chr12:1,285,282...1,287,670 JBrowse link
carvedilol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 decreases activity EXP Carvedilol results in decreased activity of CASP3 protein CTD PMID:12875697 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505 		JBrowse link
G FAS Fas cell surface death receptor decreases expression EXP Carvedilol results in decreased expression of FAS CTD PMID:12875697 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321 		JBrowse link
G FASLG Fas ligand decreases expression EXP Carvedilol results in decreased expression of FASLG CTD PMID:12875697 NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224 		JBrowse link
G NT5E 5'-nucleotidase ecto increases activity EXP Carvedilol results in increased activity of NT5E protein CTD PMID:15148268 NCBI chr12:45,491,028...45,520,019
Ensembl chr12:45,491,733...45,518,405 		JBrowse link
G RYR2 ryanodine receptor 2 multiple interactions EXP Carvedilol results in decreased oxidation of and results in increased stability of RYR2 protein CTD PMID:17448375 NCBI chr 4:2,371,868...2,908,132
Ensembl chr 4:2,373,114...2,907,875 		JBrowse link
Ceronapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme decreases activity EXP ceronapril results in decreased activity of ACE protein CTD PMID:1812274 NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358 		JBrowse link
ceruletide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCT secretin multiple interactions EXP [Ceruletide co-treated with SCT protein] results in increased abundance of Bicarbonates CTD PMID:3562434
cilazapril monohydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen decreases expression EXP Cilazapril results in decreased expression of AGT protein CTD PMID:2419701 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G REN renin increases activity EXP Cilazapril results in increased activity of REN protein CTD PMID:2419701 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
cilostazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression EXP Cilostazol results in decreased expression of MYC mRNA CTD PMID:19545562 NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309 		JBrowse link
cimetidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A2 solute carrier family 22 member 2 decreases activity EXP Cimetidine results in decreased activity of SLC22A2 protein CTD PMID:36669674 NCBI chr 1:49,327,621...49,348,435
Ensembl chr 1:49,327,296...49,348,435 		JBrowse link
cisapride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions EXP Cisapride binds to and results in decreased activity of KCNH2 protein CTD PMID:12388285 NCBI chr16:15,009,031...15,041,786
Ensembl chr16:15,009,031...15,041,504 		JBrowse link
clofibrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAA2 acetyl-CoA acyltransferase 2 increases expression EXP Clofibrate results in increased expression of ACAA2 mRNA CTD PMID:19952500 NCBI chr 7:79,028,636...79,057,720 JBrowse link
G ACADVL acyl-CoA dehydrogenase very long chain increases expression EXP Clofibrate results in increased expression of ACADVL protein CTD PMID:19952500 NCBI chr 5:32,189,191...32,194,255
Ensembl chr 5:32,186,502...32,327,990 		JBrowse link
G AGXT alanine--glyoxylate and serine--pyruvate aminotransferase decreases expression EXP Clofibrate results in decreased expression of AGXT protein CTD PMID:19952500 NCBI chr25:50,968,291...50,976,089 JBrowse link
G AHCY adenosylhomocysteinase decreases expression EXP Clofibrate results in decreased expression of AHCY protein CTD PMID:19952500 NCBI chr24:23,410,553...23,423,494
Ensembl chr24:23,411,140...23,419,767 		JBrowse link
G ASL argininosuccinate lyase increases expression EXP Clofibrate results in increased expression of ASL protein CTD PMID:19952500 NCBI chr 6:768,522...779,144
Ensembl chr 6:730,358...779,424 		JBrowse link
G ASS1 argininosuccinate synthase 1 decreases expression EXP Clofibrate results in decreased expression of ASS1 protein CTD PMID:19952500 NCBI chr 9:53,425,228...53,478,007
Ensembl chr 9:53,425,448...53,477,904 		JBrowse link
G CPS1 carbamoyl-phosphate synthase 1 increases expression EXP Clofibrate results in increased expression of CPS1 protein CTD PMID:19952500 NCBI chr37:18,308,164...18,428,487
Ensembl chr37:18,143,986...18,427,697 		JBrowse link
G CPT2 carnitine palmitoyltransferase 2 increases expression EXP Clofibrate results in increased expression of CPT2 mRNA CTD PMID:19952500 NCBI chr 5:55,718,209...55,786,175
Ensembl chr 5:55,718,510...55,744,809 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases expression EXP Clofibrate results in decreased expression of CYP1A2 mRNA CTD PMID:19952500 NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135 		JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A polypeptide 13 decreases expression EXP Clofibrate results in decreased expression of CYP2A13 mRNA CTD PMID:19952500 NCBI chr 1:112,932,246...112,938,248
Ensembl chr 1:112,931,985...112,938,350 		JBrowse link
G CYP2B6 cytochrome P450 2B11 decreases expression EXP Clofibrate results in decreased expression of CYP2B6 mRNA CTD PMID:19952500 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293 		JBrowse link
G CYP2C18 cytochrome P450 2C21 decreases expression EXP Clofibrate results in decreased expression of CYP2C18 mRNA CTD PMID:19952500 NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 increases expression EXP Clofibrate results in increased expression of CYP2E1 protein CTD PMID:19952500 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754 		JBrowse link
G CYP3A12 cytochrome P-450 3A12 decreases expression EXP Clofibrate results in decreased expression of CYP3A12 mRNA CTD PMID:19952500
G CYP3A26 cytochrome P450 3A26 decreases expression EXP Clofibrate results in decreased expression of CYP3A26 mRNA CTD PMID:19952500 NCBI chr 6:9,777,663...9,815,345
Ensembl chr 6:9,777,659...9,869,352 		JBrowse link
G CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 increases expression EXP Clofibrate results in increased expression of CYP4A11 mRNA CTD PMID:19952500 NCBI chr15:13,663,337...13,676,350
Ensembl chr15:13,604,130...13,676,344 		JBrowse link
G DLST dihydrolipoamide S-succinyltransferase increases expression EXP Clofibrate results in increased expression of DLST protein CTD PMID:19952500 NCBI chr 8:48,003,730...48,025,001
Ensembl chr 8:48,002,211...48,024,999 		JBrowse link
G ECHS1 enoyl-CoA hydratase, short chain 1 increases expression EXP Clofibrate results in increased expression of ECHS1 protein CTD PMID:19952500 NCBI chr28:40,939,856...40,947,694
Ensembl chr28:40,939,961...40,946,167 		JBrowse link
G GDI1 GDP dissociation inhibitor 1 increases expression EXP Clofibrate results in increased expression of GDI1 protein CTD PMID:19952500 NCBI chr  X:122,141,633...122,146,724
Ensembl chr  X:122,141,566...122,146,824 		JBrowse link
G GSTA4 glutathione S-transferase alpha 4 decreases expression EXP Clofibrate results in decreased expression of GSTA4 mRNA CTD PMID:19952500 NCBI chr12:20,426,724...20,443,200
Ensembl chr12:20,426,726...20,443,200 		JBrowse link
G GSTK1 glutathione S-transferase kappa 1 decreases expression EXP Clofibrate results in decreased expression of GSTK1 mRNA CTD PMID:19952500 NCBI chr16:6,411,678...6,416,135 JBrowse link
G GSTO1 glutathione S-transferase omega 1 decreases expression EXP Clofibrate results in decreased expression of GSTO1 mRNA CTD PMID:19952500 NCBI chr28:16,569,421...16,579,239
Ensembl chr28:16,569,066...16,619,880 		JBrowse link
G HADH hydroxyacyl-CoA dehydrogenase increases expression EXP Clofibrate results in increased expression of HADH mRNA CTD PMID:19952500 NCBI chr32:28,460,445...28,506,141
Ensembl chr32:28,460,193...28,531,280 		JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 increases expression EXP Clofibrate results in increased expression of HSPD1 protein CTD PMID:19952500 NCBI chr37:7,010,421...7,025,912 JBrowse link
G KRT1 keratin 1 increases expression EXP Clofibrate results in increased expression of KRT1 protein CTD PMID:19952500 NCBI chr27:2,422,150...2,427,160 JBrowse link
G KRT18 keratin 18 decreases expression EXP Clofibrate results in decreased expression of KRT18 protein CTD PMID:19952500 NCBI chr27:2,189,269...2,193,368
Ensembl chr27:2,189,269...2,193,368 		JBrowse link
G LOC474938 glutathione S-transferase A2 decreases expression EXP Clofibrate results in decreased expression of GSTA3 mRNA; Clofibrate results in decreased expression of GSTA3 protein CTD PMID:19952500 NCBI chr12:20,349,133...20,365,023 JBrowse link
G LOC479912 glutathione S-transferase Mu 1 decreases expression EXP Clofibrate results in decreased expression of GSTM1 mRNA CTD PMID:19952500 NCBI chr 6:42,201,697...42,207,886 JBrowse link
G MGST1 microsomal glutathione S-transferase 1 increases expression EXP Clofibrate results in increased expression of MGST1 mRNA CTD PMID:19952500 NCBI chr27:30,370,588...30,391,898
Ensembl chr27:30,370,594...30,391,778 		JBrowse link
G PC pyruvate carboxylase increases expression EXP Clofibrate results in increased expression of PC protein CTD PMID:19952500 NCBI chr18:50,406,994...50,507,677
Ensembl chr18:50,412,272...50,507,669 		JBrowse link
G PCK2 phosphoenolpyruvate carboxykinase 2, mitochondrial increases expression EXP Clofibrate results in increased expression of PCK2 protein CTD PMID:19952500 NCBI chr 8:4,099,016...4,107,870
Ensembl chr 8:4,098,671...4,107,865 		JBrowse link
G PRDX6 peroxiredoxin 6 decreases expression EXP Clofibrate results in decreased expression of PRDX6 protein CTD PMID:19952500 NCBI chr 7:25,663,238...25,675,855
Ensembl chr 7:25,663,579...25,675,754 		JBrowse link
G SELENBP1 selenium binding protein 1 decreases expression EXP Clofibrate results in decreased expression of SELENBP1 protein CTD PMID:19952500 NCBI chr17:60,410,727...60,418,770
Ensembl chr17:60,410,734...60,418,704 		JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 decreases expression EXP Clofibrate results in decreased expression of SHMT1 protein CTD PMID:19952500 NCBI chr 5:41,221,531...41,248,653
Ensembl chr 5:41,221,562...41,253,166 		JBrowse link
G UGP2 UDP-glucose pyrophosphorylase 2 decreases expression EXP Clofibrate results in decreased expression of UGP2 protein CTD PMID:19952500 NCBI chr10:63,532,366...63,598,362
Ensembl chr10:63,533,171...63,597,452 		JBrowse link
G UQCRC1 ubiquinol-cytochrome c reductase core protein 1 increases expression EXP Clofibrate results in increased expression of UQCRC1 protein CTD PMID:19952500 NCBI chr20:40,507,767...40,515,854
Ensembl chr20:40,506,907...40,520,110 		JBrowse link
G UROC1 urocanate hydratase 1 decreases expression EXP Clofibrate results in decreased expression of UROC1 protein CTD PMID:19952500 NCBI chr20:676,624...717,109
Ensembl chr20:678,073...717,141 		JBrowse link
corticotropin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin increases abundance EXP INS protein results in increased abundance of Adrenocorticotropic Hormone CTD PMID:1646414 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
cortisol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRH corticotropin releasing hormone increases abundance EXP CRH protein results in increased abundance of Hydrocortisone CTD PMID:2831029 NCBI chr29:15,831,944...15,840,560
Ensembl chr29:15,831,944...15,834,384 		JBrowse link
G INS insulin affects abundance
multiple interactions		 EXP INS protein affects the abundance of Hydrocortisone
Sodium affects the reaction [INS protein affects the abundance of Hydrocortisone]		 CTD PMID:1324617 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
G POMC proopiomelanocortin increases abundance EXP POMC protein results in increased abundance of Hydrocortisone CTD PMID:2831029 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440 		JBrowse link
cyclophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6 cytochrome P450 2B11 increases hydroxylation EXP CYP2B6 protein results in increased hydroxylation of Cyclophosphamide CTD PMID:16546968 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293 		JBrowse link
cytidine 5'-monophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions EXP [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate CTD PMID:2579070 NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653 		JBrowse link
D-glucitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP Sorbitol results in increased phosphorylation of MAPK1 protein CTD PMID:12639917 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP Sorbitol results in increased phosphorylation of MAPK3 protein CTD PMID:12639917 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
D-glucose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin multiple interactions
decreases abundance		 EXP [INS protein co-treated with Glucose] results in decreased abundance of Potassium; [INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin
INS protein results in decreased abundance of Glucose		 CTD PMID:140932 PMID:1013176 PMID:1646414 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
D-mannitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 increases expression EXP Mannitol results in increased expression of CLDN4 protein CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
denopamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 multiple interactions EXP denopamine binds to and results in increased activity of ADRB1 protein CTD PMID:3831029 NCBI chr28:24,908,224...24,909,684
Ensembl chr28:24,908,224...24,909,684 		JBrowse link
desferrioxamine B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions EXP Deferoxamine inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin] CTD PMID:8021468 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
dexamethasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AVP arginine vasopressin decreases expression EXP Dexamethasone results in decreased expression of AVP protein CTD PMID:1934541 NCBI chr24:18,183,057...18,184,827
Ensembl chr24:18,183,057...18,184,883 		JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 increases expression EXP Dexamethasone results in increased expression of HSD11B1 mRNA CTD PMID:21798686 NCBI chr 7:8,344,380...8,409,901
Ensembl chr 7:8,344,447...8,409,897 		JBrowse link
G NPPA natriuretic peptide A increases expression EXP Dexamethasone results in increased expression of NPPA protein CTD PMID:1934541 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385 		JBrowse link
dextromethorphan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6 cytochrome P450 2B11 increases metabolic processing EXP CYP2B6 protein results in increased metabolism of Dextromethorphan CTD PMID:12637241 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293 		JBrowse link
G CYP2D15 cytochrome P450 family 2 subfamily D member 15 affects metabolic processing EXP CYP2D15 affects the metabolism of Dextromethorphan CTD PMID:7786018 NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298 		JBrowse link
dichlorvos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase decreases activity EXP Dichlorvos results in decreased activity of ACHE protein CTD PMID:89824 PMID:3627083 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702 		JBrowse link
G BCHE butyrylcholinesterase decreases activity EXP Dichlorvos results in decreased activity of BCHE protein CTD PMID:3627083 PMID:4631366 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583 		JBrowse link
diclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C41 cytochrome P450 2C41 affects metabolic processing
increases hydroxylation		 EXP CYP2C9 protein affects the metabolism of Diclofenac
CYP2C19 protein results in increased hydroxylation of Diclofenac		 CTD PMID:15677349 PMID:15801540
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Diclofenac results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
diethyldithiocarbamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions EXP Ditiocarb inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene] CTD PMID:8592870 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754 		JBrowse link
digoxin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
increases response to substance		 EXP [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin]; [Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of TTR mRNA]; MYL9 protein modified form affects the reaction [ABCB1 protein affects the transport of Digoxin analog]
ABCB1 gene mutant form results in increased susceptibility to Digoxin; ABCB1 mutant form results in increased susceptibility to Digoxin		 CTD PMID:16594604 PMID:20510202 PMID:23186803 PMID:25419811 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G ALB albumin multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of ALB mRNA] CTD PMID:25419811 NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709 		JBrowse link
G DAO D-amino acid oxidase multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of DAO mRNA] CTD PMID:25419811 NCBI chr26:18,032,663...18,057,277
Ensembl chr26:18,033,392...18,057,238 		JBrowse link
G EBF3 EBF transcription factor 3 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of EBF3 mRNA] CTD PMID:25419811 NCBI chr28:38,489,635...38,601,800
Ensembl chr28:38,491,047...38,602,022 		JBrowse link
G GABRQ gamma-aminobutyric acid type A receptor subunit theta multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GABRQ mRNA] CTD PMID:25419811 NCBI chr  X:120,607,815...120,630,251
Ensembl chr  X:120,607,686...120,628,343 		JBrowse link
G GLRA1 glycine receptor alpha 1 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of GLRA1 mRNA] CTD PMID:25419811 NCBI chr 4:57,443,094...57,541,494
Ensembl chr 4:57,443,999...57,528,376 		JBrowse link
G INS insulin multiple interactions EXP [INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin CTD PMID:140932 PMID:1013176 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
G KLK6 kallikrein related peptidase 6 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of KLK6 mRNA] CTD PMID:25419811 NCBI chr 1:105,902,147...105,907,585 JBrowse link
G MAB21L2 mab-21 like 2 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of MAB21L2 mRNA] CTD PMID:25419811 NCBI chr15:48,538,912...48,541,651
Ensembl chr15:48,539,955...48,541,034 		JBrowse link
G MYL9 myosin light chain 9 multiple interactions EXP MYL9 protein modified form affects the reaction [ABCB1 protein affects the transport of Digoxin analog] CTD PMID:20510202 NCBI chr24:25,322,800...25,329,937
Ensembl chr24:25,322,800...25,329,932 		JBrowse link
G MYLK myosin light chain kinase multiple interactions EXP [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin] CTD PMID:20510202 NCBI chr33:26,663,991...26,867,370
Ensembl chr33:26,664,800...26,843,181 		JBrowse link
G SLC10A4 solute carrier family 10 member 4 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC10A4 mRNA] CTD PMID:25419811 NCBI chr13:44,293,956...44,299,529
Ensembl chr13:44,277,094...44,299,732 		JBrowse link
G SLC18A2 solute carrier family 18 member A2 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of SLC18A2 mRNA] CTD PMID:25419811 NCBI chr28:27,731,709...27,809,341
Ensembl chr28:27,731,004...27,767,993 		JBrowse link
G TTR transthyretin multiple interactions EXP ABCB1 gene mutant form affects the reaction [Digoxin affects the expression of TTR mRNA] CTD PMID:25419811 NCBI chr 7:57,940,354...57,947,084
Ensembl chr 7:57,914,381...57,947,058 		JBrowse link
dihexadecanoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 multiple interactions
increases activity		 EXP dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]
dipalmitoylphosphatidic acid results in increased activity of PLCG1 protein		 CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
diisopropyl fluorophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase decreases activity EXP Isoflurophate results in decreased activity of BCHE protein CTD PMID:4631366 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583 		JBrowse link
dimyristoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP dimyristoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
dioleoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP dioleoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
diosgenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 multiple interactions EXP Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP3 protein] CTD PMID:25446497 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505 		JBrowse link
G CASP9 caspase 9 multiple interactions EXP Diosgenin inhibits the reaction [Calcium Oxalate results in increased activity of CASP9 protein] CTD PMID:25446497 NCBI chr 2:82,033,759...82,076,710
Ensembl chr 2:82,031,563...82,090,484 		JBrowse link
dioxygen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of CXCL8 protein] CTD PMID:18339021 NCBI chr13:62,435,035...62,438,354
Ensembl chr13:62,434,422...62,438,354 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions EXP Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP2 protein] CTD PMID:18339021 NCBI chr 2:60,471,092...60,492,991
Ensembl chr 2:60,471,257...60,494,113 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions EXP Oxygen inhibits the reaction [Hydrochloric Acid results in increased expression of MMP9 protein] CTD PMID:18339021 NCBI chr24:33,274,260...33,281,116
Ensembl chr24:33,274,268...33,281,293 		JBrowse link
Doramectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases response to substance
multiple interactions		 EXP ABCB1 gene mutant form results in increased susceptibility to doramectin; ABCB1 mutant form results in increased susceptibility to doramectin
ABCB1 gene mutant form affects the reaction [doramectin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [doramectin affects the expression of TTR mRNA]		 CTD PMID:22834856 PMID:23186803 PMID:25419811 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G ALB albumin multiple interactions EXP ABCB1 gene mutant form affects the reaction [doramectin affects the expression of ALB mRNA] CTD PMID:25419811 NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709 		JBrowse link
G DAO D-amino acid oxidase multiple interactions EXP ABCB1 gene mutant form affects the reaction [doramectin affects the expression of DAO mRNA] CTD PMID:25419811 NCBI chr26:18,032,663...18,057,277
Ensembl chr26:18,033,392...18,057,238 		JBrowse link
G EBF3 EBF transcription factor 3 multiple interactions EXP ABCB1 gene mutant form affects the reaction [doramectin affects the expression of EBF3 mRNA] CTD PMID:25419811 NCBI chr28:38,489,635...38,601,800
Ensembl chr28:38,491,047...38,602,022 		JBrowse link
G GABRQ gamma-aminobutyric acid type A receptor subunit theta multiple interactions EXP ABCB1 gene mutant form affects the reaction [doramectin affects the expression of GABRQ mRNA] CTD PMID:25419811 NCBI chr  X:120,607,815...120,630,251
Ensembl chr  X:120,607,686...120,628,343 		JBrowse link
G GLRA1 glycine receptor alpha 1 multiple interactions EXP ABCB1 gene mutant form affects the reaction [doramectin affects the expression of GLRA1 mRNA] CTD PMID:25419811 NCBI chr 4:57,443,094...57,541,494
Ensembl chr 4:57,443,999...57,528,376 		JBrowse link
G KLK6 kallikrein related peptidase 6 multiple interactions EXP ABCB1 gene mutant form affects the reaction [doramectin affects the expression of KLK6 mRNA] CTD PMID:25419811 NCBI chr 1:105,902,147...105,907,585 JBrowse link
G MAB21L2 mab-21 like 2 multiple interactions EXP ABCB1 gene mutant form affects the reaction [doramectin affects the expression of MAB21L2 mRNA] CTD PMID:25419811 NCBI chr15:48,538,912...48,541,651
Ensembl chr15:48,539,955...48,541,034 		JBrowse link
G SLC10A4 solute carrier family 10 member 4 multiple interactions EXP ABCB1 gene mutant form affects the reaction [doramectin affects the expression of SLC10A4 mRNA] CTD PMID:25419811 NCBI chr13:44,293,956...44,299,529
Ensembl chr13:44,277,094...44,299,732 		JBrowse link
G SLC18A2 solute carrier family 18 member A2 multiple interactions EXP ABCB1 gene mutant form affects the reaction [doramectin affects the expression of SLC18A2 mRNA] CTD PMID:25419811 NCBI chr28:27,731,709...27,809,341
Ensembl chr28:27,731,004...27,767,993 		JBrowse link
G TTR transthyretin multiple interactions EXP ABCB1 gene mutant form affects the reaction [doramectin affects the expression of TTR mRNA] CTD PMID:25419811 NCBI chr 7:57,940,354...57,947,084
Ensembl chr 7:57,914,381...57,947,058 		JBrowse link
doxorubicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression
affects response to substance
multiple interactions		 EXP Doxorubicin results in increased expression of ABCB1 protein
ABCB1 protein affects the susceptibility to Doxorubicin
valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin]		 CTD PMID:15492788 PMID:24975508 PMID:28093773 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G HGF hepatocyte growth factor decreases response to substance EXP HGF protein results in decreased susceptibility to Doxorubicin CTD PMID:15688034 NCBI chr18:21,329,688...21,410,257
Ensembl chr18:21,332,817...21,410,263 		JBrowse link
G TNNT2 troponin T2, cardiac type affects expression EXP Doxorubicin affects the expression of TNNT2 protein CTD PMID:12322705 NCBI chr 7:1,598,306...1,620,531
Ensembl chr 7:1,598,306...1,613,741 		JBrowse link
G VIP vasoactive intestinal peptide decreases expression EXP Doxorubicin results in decreased expression of VIP protein CTD PMID:3711722 NCBI chr 1:42,941,655...42,950,160
Ensembl chr 1:42,941,224...42,950,700 		JBrowse link
G XIAP X-linked inhibitor of apoptosis affects response to substance EXP XIAP affects the susceptibility to Doxorubicin CTD PMID:16953886 NCBI chr  X:95,300,234...95,356,103
Ensembl chr  X:95,331,827...95,351,582 		JBrowse link
DPDPE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B2 solute carrier organic anion transporter family member 1B2 increases transport EXP SLCO1B3 protein results in increased transport of Enkephalin, D-Penicillamine (2,5)- CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989 		JBrowse link
edaravone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SELP selectin P decreases expression EXP Edaravone results in decreased expression of SELP protein CTD PMID:16041266 NCBI chr 7:28,956,428...28,997,266
Ensembl chr 7:28,958,486...28,996,313 		JBrowse link
emodepside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects response to substance EXP ABCB1 protein affects the susceptibility to emodepside CTD PMID:25660379 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
enalapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of ATP2A2 protein CTD PMID:18820026 NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388 		JBrowse link
G EGR1 early growth response 1 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of EGR1 protein CTD PMID:18820026 NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575 		JBrowse link
G GATA4 GATA binding protein 4 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein CTD PMID:18820026 NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989 		JBrowse link
G KCND3 potassium voltage-gated channel subfamily D member 3 decreases expression EXP Enalapril results in decreased expression of KCND3 mRNA CTD PMID:19732978 NCBI chr17:63,470,829...63,668,354
Ensembl chr17:63,470,415...63,668,035 		JBrowse link
G NAB1 NGFI-A binding protein 1 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of NAB1 protein CTD PMID:18820026 NCBI chr37:1,207,619...1,243,546
Ensembl chr37:1,207,638...1,241,610 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
increases expression		 EXP FR 173657 inhibits the reaction [Enalapril results in increased expression of NOS3 mRNA] CTD PMID:12019275 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277 		JBrowse link
G NPPA natriuretic peptide A decreases expression
multiple interactions		 EXP Enalapril results in decreased expression of NPPA protein
FR 173657 inhibits the reaction [Enalapril results in decreased expression of NPPA protein]		 CTD PMID:12019275 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385 		JBrowse link
G REN renin increases activity
multiple interactions		 EXP Enalapril results in increased activity of REN protein
[Enalapril co-treated with FR 173657] results in increased activity of REN protein		 CTD PMID:12019275 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
G SLC8A1 solute carrier family 8 member A1 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein CTD PMID:18820026 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700 		JBrowse link
eplerenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AR androgen receptor multiple interactions EXP Eplerenone binds to and results in decreased activity of AR protein CTD PMID:23242577 NCBI chr24:34,713,390...34,731,461
NCBI chr  X:51,969,785...52,167,450
Ensembl chr  X:51,969,785...52,151,912 		JBrowse link
estrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPI alkaline phosphatase, intestinal increases chemical synthesis EXP ALPI protein results in increased chemical synthesis of Estrone CTD PMID:1495895 NCBI chr25:44,107,418...44,110,947 JBrowse link
estrone 3-sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B2 solute carrier organic anion transporter family member 1B2 increases transport EXP SLCO1B3 protein results in increased transport of estrone sulfate CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989 		JBrowse link
etodolac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP Etodolac results in decreased expression of PTGS2 mRNA CTD PMID:15198222 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903 		JBrowse link
etoposide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 decreases response to substance EXP ABCC1 protein results in decreased susceptibility to Etoposide CTD PMID:12516967 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331 		JBrowse link
felodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Felodipine results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
flufenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPNE6 copine 6 decreases activity EXP Flufenamic Acid results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
ganglioside GM1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNAQ G protein subunit alpha q multiple interactions EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein] CTD PMID:21671308 NCBI chr 1:80,733,530...80,928,065
Ensembl chr 1:80,715,366...80,928,065 		JBrowse link
G HEXB hexosaminidase subunit beta multiple interactions EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; G(M1) Ganglioside inhibits the reaction [Melitten results in increased secretion of HEXB protein]; G(M1) Ganglioside inhibits the reaction [Wasp Venoms results in increased secretion of HEXB protein] CTD PMID:21334356 PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417 		JBrowse link
genistein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator decreases activity EXP Genistein results in decreased activity of CFTR protein CTD PMID:15496164 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977 		JBrowse link
G CPNE6 copine 6 decreases activity EXP Genistein results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
gentamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 C-C motif chemokine ligand 2 increases expression EXP Gentamicins results in increased expression of CCL2 protein CTD PMID:33290828 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G CLU clusterin increases expression EXP Gentamicins results in increased expression of CLU mRNA; Gentamicins results in increased expression of CLU protein CTD PMID:25034533 PMID:33290828 NCBI chr25:29,982,811...29,999,565
Ensembl chr25:29,982,811...29,999,563 		JBrowse link
G LCN2 lipocalin 2 increases expression EXP Gentamicins results in increased expression of LCN2 mRNA; Gentamicins results in increased expression of LCN2 protein CTD PMID:25034533 PMID:33290828 NCBI chr 9:55,328,118...55,342,535
Ensembl chr 9:55,328,133...55,332,038 		JBrowse link
G LOC607874 cystatin-C-like increases expression EXP Gentamicins results in increased expression of CST3 protein CTD PMID:33290828 NCBI chr23:49,562...53,618 JBrowse link
G MIR15B microRNA mir-15b affects expression EXP Gentamicins affects the expression of MIR15B mRNA CTD PMID:33290828 NCBI chr34:26,460,663...26,460,722
Ensembl chr34:26,460,645...26,460,741 		JBrowse link
G MIR30A microRNA mir-30a increases expression EXP Gentamicins results in increased expression of MIR30A mRNA CTD PMID:33290828 NCBI chr12:33,783,894...33,783,956
Ensembl chr12:33,783,891...33,783,961 		JBrowse link
G SPP1 secreted phosphoprotein 1 increases expression EXP Gentamicins results in increased expression of SPP1 protein CTD PMID:33290828 NCBI chr32:11,354,070...11,362,325
Ensembl chr32:11,353,953...11,362,069 		JBrowse link
glucose term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin decreases abundance
multiple interactions		 EXP INS protein results in decreased abundance of Glucose
[INS protein co-treated with Glucose] results in decreased abundance of Potassium; [INS protein co-treated with Glucose] results in increased susceptibility to Digoxin; [INS protein co-treated with Glucose] results in increased uptake of Digoxin		 CTD PMID:140932 PMID:1013176 PMID:1646414 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] CTD PMID:23816505 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:23816505 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119 		JBrowse link
glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator decreases activity EXP Glyburide results in decreased activity of CFTR protein CTD PMID:15496164 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977 		JBrowse link
hexaconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC47A1 solute carrier family 47 member 1 decreases activity EXP hexaconazole results in decreased activity of SLC47A1 protein CTD PMID:36669674 NCBI chr 5:40,643,420...40,679,130
Ensembl chr 5:40,642,784...40,679,946 		JBrowse link
G SLC47A2 solute carrier family 47 member 2 decreases activity EXP hexaconazole results in decreased activity of SLC47A2 protein CTD PMID:36669674 NCBI chr 5:40,491,306...40,515,430
Ensembl chr 5:40,491,933...40,540,136 		JBrowse link
hexane-2,3-dione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPNE6 copine 6 increases reduction EXP DHRS4 protein results in increased reduction of 2,3-hexanedione CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
hydrogen peroxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions
increases expression		 EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions
increases phosphorylation		 EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein] CTD PMID:23816505 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation
multiple interactions		 EXP Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]		 CTD PMID:23816505 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 EXP Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein
Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]		 CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions
increases phosphorylation		 EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119 		JBrowse link
G SOD2 superoxide dismutase 2 multiple interactions
decreases activity		 EXP Dihydrotestosterone promotes the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein] CTD PMID:16682413 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706 		JBrowse link
hydrogencarbonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCT secretin increases abundance
multiple interactions		 EXP SCT protein results in increased abundance of Bicarbonates
[Ceruletide co-treated with SCT protein] results in increased abundance of Bicarbonates; Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates]		 CTD PMID:3562434
ibuprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Ibuprofen results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 increases expression EXP Ibuprofen results in increased expression of PTGS2 protein CTD PMID:16105799 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903 		JBrowse link
icariin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 increases activity EXP icariin results in increased activity of NOS3 protein CTD PMID:17438405 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277 		JBrowse link
idazoxan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NISCH nischarin multiple interactions EXP Idazoxan binds to and results in decreased activity of NISCH protein CTD PMID:8732285 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636 		JBrowse link
indometacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions EXP Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Indomethacin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
indoxyl sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A6 solute carrier family 22 member 6 multiple interactions EXP [Lansoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican; [Omeprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican; [Pantoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr18:53,736,669...53,745,001
Ensembl chr18:53,736,959...53,744,396 		JBrowse link
inositol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions EXP [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate; Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides] CTD PMID:2579070 NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653 		JBrowse link
iprodione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP [iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866 		JBrowse link
isoprenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin multiple interactions
increases activity		 EXP Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; Pindolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; xibenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] CTD PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
ivermectin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects abundance
increases response to substance
multiple interactions		 EXP ABCB1 protein affects the abundance of Ivermectin
ABCB1 gene mutant form results in increased susceptibility to Ivermectin; ABCB1 mutant form results in increased susceptibility to Ivermectin; ABCB1 protein mutant form results in increased susceptibility to Ivermectin
ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of TTR mRNA]		 CTD PMID:20595473 PMID:22834856 PMID:22924731 PMID:23186803 PMID:25419811 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G ALB albumin multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of ALB mRNA] CTD PMID:25419811 NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709 		JBrowse link
G DAO D-amino acid oxidase multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of DAO mRNA] CTD PMID:25419811 NCBI chr26:18,032,663...18,057,277
Ensembl chr26:18,033,392...18,057,238 		JBrowse link
G EBF3 EBF transcription factor 3 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of EBF3 mRNA] CTD PMID:25419811 NCBI chr28:38,489,635...38,601,800
Ensembl chr28:38,491,047...38,602,022 		JBrowse link
G GABRQ gamma-aminobutyric acid type A receptor subunit theta multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GABRQ mRNA] CTD PMID:25419811 NCBI chr  X:120,607,815...120,630,251
Ensembl chr  X:120,607,686...120,628,343 		JBrowse link
G GLRA1 glycine receptor alpha 1 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of GLRA1 mRNA] CTD PMID:25419811 NCBI chr 4:57,443,094...57,541,494
Ensembl chr 4:57,443,999...57,528,376 		JBrowse link
G KLK6 kallikrein related peptidase 6 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of KLK6 mRNA] CTD PMID:25419811 NCBI chr 1:105,902,147...105,907,585 JBrowse link
G MAB21L2 mab-21 like 2 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of MAB21L2 mRNA] CTD PMID:25419811 NCBI chr15:48,538,912...48,541,651
Ensembl chr15:48,539,955...48,541,034 		JBrowse link
G SLC10A4 solute carrier family 10 member 4 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC10A4 mRNA] CTD PMID:25419811 NCBI chr13:44,293,956...44,299,529
Ensembl chr13:44,277,094...44,299,732 		JBrowse link
G SLC18A2 solute carrier family 18 member A2 multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of SLC18A2 mRNA] CTD PMID:25419811 NCBI chr28:27,731,709...27,809,341
Ensembl chr28:27,731,004...27,767,993 		JBrowse link
G TTR transthyretin multiple interactions EXP ABCB1 gene mutant form affects the reaction [Ivermectin affects the expression of TTR mRNA] CTD PMID:25419811 NCBI chr 7:57,940,354...57,947,084
Ensembl chr 7:57,914,381...57,947,058 		JBrowse link
kaempferol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] CTD PMID:15266218 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G CPNE6 copine 6 decreases activity EXP kaempferol results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
ketoconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases expression
multiple interactions
decreases activity		 EXP Ketoconazole results in decreased expression of ABCB1 mRNA
[Ketoconazole results in decreased activity of ABCB1 protein] which results in decreased transport of Technetium Tc 99m Sestamibi		 CTD PMID:19754906 PMID:22620706 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G CYP3A12 cytochrome P-450 3A12 multiple interactions
decreases activity		 EXP Ketoconazole inhibits the reaction [CYP3A12 protein results in increased hydroxylation of Diazepam]
Ketoconazole results in decreased activity of CYP3A12 protein		 CTD PMID:15677349
L-1,4-dithiothreitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Dithiothreitol metabolite results in increased expression of HSPA5 protein CTD PMID:17416481 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257 		JBrowse link
lansoprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A6 solute carrier family 22 member 6 multiple interactions EXP [Lansoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr18:53,736,669...53,745,001
Ensembl chr18:53,736,959...53,744,396 		JBrowse link
leukotriene C4 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC1 ATP binding cassette subfamily C member 1 affects transport EXP ABCC1 protein affects the transport of Leukotriene C4 CTD PMID:12516967 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331 		JBrowse link
G ABCC2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 protein affects the transport of Leukotriene C4 CTD PMID:15507541 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740 		JBrowse link
lipopolysaccharide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 increases expression EXP Lipopolysaccharides results in increased expression of HSD11B1 mRNA CTD PMID:21798686 NCBI chr 7:8,344,380...8,409,901
Ensembl chr 7:8,344,447...8,409,897 		JBrowse link
G HSP70 heat shock protein 70 multiple interactions EXP HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]] CTD PMID:32899721 NCBI chr12:1,285,282...1,287,670 JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases expression		 EXP arsenite affects the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]] CTD PMID:32899721 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
G IL6 interleukin 6 multiple interactions
increases expression		 EXP arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]] CTD PMID:32899721 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation		 EXP arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]] CTD PMID:32899721 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875 		JBrowse link
G TNF tumor necrosis factor multiple interactions
increases expression		 EXP arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] CTD PMID:32899721 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
lithocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPNE6 copine 6 decreases activity EXP Lithocholic Acid results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
loperamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects response to substance
increases export		 EXP ABCB1 protein affects the susceptibility to Loperamide
ABCB1 protein results in increased export of Loperamide		 CTD PMID:25660379 PMID:28093773 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
loratadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity EXP Loratadine results in increased activity of CASP3 protein CTD PMID:20570632 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505 		JBrowse link
luteolin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL17 C-C motif chemokine ligand 17 multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of CCL17 promoter CTD PMID:33763461 NCBI chr 2:59,001,463...59,014,347
Ensembl chr 2:59,001,464...59,005,230 		JBrowse link
G CCL2 C-C motif chemokine ligand 2 multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of CCL2 promoter CTD PMID:33763461 NCBI chr 9:39,008,187...39,009,932 JBrowse link
G IL13 interleukin 13 multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA] CTD PMID:33763461 NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388 		JBrowse link
G IL31 interleukin 31 multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA] CTD PMID:33763461 NCBI chr26:7,173,151...7,175,195
Ensembl chr26:7,172,451...7,175,195 		JBrowse link
G IL31RA interleukin 31 receptor A multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of IL31RA promoter CTD PMID:33763461 NCBI chr 2:43,113,194...43,198,200
Ensembl chr 2:43,144,071...43,193,293 		JBrowse link
G IL4 interleukin 4 multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL17 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of CCL2 mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of IL31RA mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA] CTD PMID:33763461 NCBI chr11:20,972,693...20,981,539
Ensembl chr11:20,972,690...20,981,534 		JBrowse link
G TSLP thymic stromal lymphopoietin multiple interactions EXP [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] inhibits the reaction [[IL4 protein co-treated with IL13 protein co-treated with IL31 protein] results in increased expression of TSLP mRNA]; [Cannabidiol co-treated with Luteolin co-treated with 3,3',4,5'-tetrahydroxystilbene] results in increased methylation of TSLP promoter CTD PMID:33763461 NCBI chr 3:1,502,469...1,507,696
Ensembl chr 3:1,503,188...1,507,696 		JBrowse link
LY294002 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of PIK3CG protein] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G PRKCZ protein kinase C zeta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
marbofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP8 caspase 8 multiple interactions
increases expression		 EXP TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of CASP8 mRNA] CTD PMID:31005593 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822 		JBrowse link
G FADD Fas associated via death domain increases expression EXP marbofloxacin results in increased expression of FADD mRNA CTD PMID:31005593 NCBI chr18:48,087,447...48,094,497 JBrowse link
G TNF tumor necrosis factor increases expression EXP marbofloxacin results in increased expression of TNF mRNA; marbofloxacin results in increased expression of TNF protein CTD PMID:31005593 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A multiple interactions
increases expression		 EXP TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of CASP8 mRNA]; TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of TRADD mRNA]
marbofloxacin results in increased expression of TNFRSF1A mRNA; marbofloxacin results in increased expression of TNFRSF1A protein		 CTD PMID:31005593 NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282 		JBrowse link
G TRADD TNFRSF1A associated via death domain multiple interactions
increases expression		 EXP TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of TRADD mRNA] CTD PMID:31005593 NCBI chr 5:82,200,430...82,211,430
Ensembl chr 5:82,206,111...82,210,963 		JBrowse link
masitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA5 ATP binding cassette subfamily A member 5 increases expression EXP masitinib results in increased expression of ABCA5 mRNA CTD PMID:22747577 NCBI chr 9:15,708,070...15,781,100
Ensembl chr 9:15,420,835...15,783,045 		JBrowse link
G ABHD14A abhydrolase domain containing 14A increases expression EXP masitinib results in increased expression of ABHD14A mRNA CTD PMID:22747577 NCBI chr20:37,738,500...37,744,689 JBrowse link
G ABITRAM actin binding transcription modulator decreases expression EXP masitinib results in decreased expression of ABITRAM mRNA CTD PMID:22747577 NCBI chr11:64,094,653...64,100,078
Ensembl chr11:64,094,721...64,109,421 		JBrowse link
G ABLIM1 actin binding LIM protein 1 increases expression EXP masitinib results in increased expression of ABLIM1 mRNA CTD PMID:22747577 NCBI chr28:25,260,323...25,543,369
Ensembl chr28:25,260,873...25,545,304 		JBrowse link
G ACAT2 acetyl-CoA acetyltransferase 2 decreases expression EXP masitinib results in decreased expression of ACAT2 mRNA CTD PMID:22747577 NCBI chr 1:49,011,665...49,029,368
Ensembl chr 1:49,011,706...49,029,327 		JBrowse link
G ACSM3 acyl-CoA synthetase medium chain family member 3 increases expression EXP masitinib results in increased expression of ACSM3 mRNA CTD PMID:22747577 NCBI chr 6:24,558,010...24,594,326
Ensembl chr 6:24,558,142...24,582,728 		JBrowse link
G ACTL7A actin like 7A increases expression EXP masitinib results in increased expression of ACTL7A mRNA CTD PMID:22747577 NCBI chr11:64,031,305...64,033,908
Ensembl chr11:64,032,358...64,033,788 		JBrowse link
G ACTR2 actin related protein 2 decreases expression EXP masitinib results in decreased expression of ACTR2 protein CTD PMID:22747577 NCBI chr10:64,696,068...64,733,027
Ensembl chr10:64,696,111...64,730,553 		JBrowse link
G ADPRH ADP-ribosylarginine hydrolase increases expression EXP masitinib results in increased expression of ADPRH mRNA CTD PMID:22747577 NCBI chr33:23,218,633...23,226,844
Ensembl chr33:23,218,101...23,224,667 		JBrowse link
G AGA aspartylglucosaminidase increases expression EXP masitinib results in increased expression of AGA mRNA CTD PMID:22747577 NCBI chr16:52,314,860...52,324,879
Ensembl chr16:52,314,535...52,324,894 		JBrowse link
G AGO2 argonaute RISC catalytic component 2 decreases expression EXP masitinib results in decreased expression of AGO2 mRNA CTD PMID:22747577 NCBI chr13:35,169,243...35,230,252
Ensembl chr13:35,180,912...35,268,577 		JBrowse link
G AGRN agrin increases expression EXP masitinib results in increased expression of AGRN mRNA CTD PMID:22747577 NCBI chr 5:56,239,621...56,273,679
Ensembl chr 5:56,239,701...56,272,745 		JBrowse link
G AIG1 androgen induced 1 increases expression EXP masitinib results in increased expression of AIG1 mRNA CTD PMID:22747577 NCBI chr 1:34,643,994...34,884,445
Ensembl chr 1:34,643,764...34,884,119 		JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 increases expression EXP masitinib results in increased expression of ALAS2 mRNA CTD PMID:22747577 NCBI chr  X:46,703,477...46,731,767
Ensembl chr  X:46,703,477...46,723,529 		JBrowse link
G ALDH5A1 aldehyde dehydrogenase 5 family member A1 decreases expression EXP masitinib results in decreased expression of ALDH5A1 mRNA CTD PMID:22747577 NCBI chr35:22,560,005...22,590,996
Ensembl chr35:22,560,008...22,587,875 		JBrowse link
G AMN1 antagonist of mitotic exit network 1 homolog increases expression EXP masitinib results in increased expression of AMN1 mRNA CTD PMID:22747577 NCBI chr27:17,044,301...17,100,444
Ensembl chr27:17,044,309...17,361,570 		JBrowse link
G ANKRD26 ankyrin repeat domain containing 26 increases expression EXP masitinib results in increased expression of ANKRD26 mRNA CTD PMID:22747577 NCBI chr 2:6,230,466...6,402,360 JBrowse link
G ANP32E acidic nuclear phosphoprotein 32 family member E decreases expression EXP masitinib results in decreased expression of ANP32E mRNA CTD PMID:22747577 NCBI chr17:59,460,864...59,482,467
Ensembl chr17:59,462,766...59,477,936 		JBrowse link
G ANXA1 annexin A1 increases expression EXP masitinib results in increased expression of ANXA1 protein CTD PMID:22747577 NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011 		JBrowse link
G ANXA6 annexin A6 increases expression EXP masitinib results in increased expression of ANXA6 protein CTD PMID:22747577 NCBI chr 4:58,091,186...58,140,102
Ensembl chr 4:58,091,251...58,139,372 		JBrowse link
G ARMC12 armadillo repeat containing 12 increases expression EXP masitinib results in increased expression of ARMC12 mRNA CTD PMID:22747577 NCBI chr12:4,868,831...4,879,801
Ensembl chr12:4,869,774...4,879,793 		JBrowse link
G ASCC1 activating signal cointegrator 1 complex subunit 1 decreases expression EXP masitinib results in decreased expression of ASCC1 mRNA CTD PMID:22747577 NCBI chr 4:22,779,644...22,876,434
Ensembl chr 4:22,779,781...22,874,215 		JBrowse link
G B4GALT7 beta-1,4-galactosyltransferase 7 increases expression EXP masitinib results in increased expression of B4GALT7 mRNA CTD PMID:22747577 NCBI chr11:3,497,860...3,507,513
Ensembl chr11:3,498,153...3,505,034 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases expression EXP masitinib results in decreased expression of BIRC5 mRNA CTD PMID:22747577 NCBI chr 9:2,930,308...2,959,307 JBrowse link
G BTBD3 BTB domain containing 3 decreases expression EXP masitinib results in decreased expression of BTBD3 mRNA CTD PMID:22747577 NCBI chr24:10,478,635...10,512,773
Ensembl chr24:10,479,900...10,512,185 		JBrowse link
G CA2 carbonic anhydrase 2 decreases expression EXP masitinib results in decreased expression of CA2 mRNA CTD PMID:22747577 NCBI chr29:31,959,225...31,975,309
Ensembl chr29:31,935,172...31,980,579 		JBrowse link
G CAMK2G calcium/calmodulin dependent protein kinase II gamma increases expression EXP masitinib results in increased expression of CAMK2G mRNA CTD PMID:22747577 NCBI chr 4:24,244,063...24,299,362
Ensembl chr 4:24,245,960...24,299,357 		JBrowse link
G CAPG capping actin protein, gelsolin like increases expression EXP masitinib results in increased expression of CAPG protein CTD PMID:22747577 NCBI chr17:39,619,429...39,640,944
Ensembl chr17:39,619,248...39,640,942 		JBrowse link
G CCT2 chaperonin containing TCP1 subunit 2 decreases expression EXP masitinib results in decreased expression of CCT2 protein CTD PMID:22747577 NCBI chr10:11,560,287...11,586,559
Ensembl chr10:11,560,396...11,578,433 		JBrowse link
G CD5L CD5 molecule like increases expression EXP masitinib results in increased expression of CD5L mRNA CTD PMID:22747577 NCBI chr 7:40,516,190...40,526,528
Ensembl chr 7:40,516,190...40,526,528 		JBrowse link
G CDADC1 cytidine and dCMP deaminase domain containing 1 increases expression EXP masitinib results in increased expression of CDADC1 mRNA CTD PMID:22747577 NCBI chr22:2,443,459...2,489,147
Ensembl chr22:2,436,206...2,489,016 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP masitinib results in increased expression of CDKN1A mRNA CTD PMID:22747577 NCBI chr12:5,746,898...5,755,103
Ensembl chr12:5,745,852...5,892,281 		JBrowse link
G CIAPIN1 cytokine induced apoptosis inhibitor 1 decreases expression EXP masitinib results in decreased expression of CIAPIN1 mRNA CTD PMID:22747577 NCBI chr 2:58,977,592...58,992,785
Ensembl chr 2:58,977,676...58,992,581 		JBrowse link
G CIRBP cold inducible RNA binding protein increases expression EXP masitinib results in increased expression of CIRBP mRNA CTD PMID:22747577 NCBI chr20:57,521,609...57,526,526
Ensembl chr20:57,519,119...57,526,435 		JBrowse link
G CLEC2B C-type lectin domain family 2 member B decreases expression EXP masitinib results in decreased expression of CLEC2B mRNA CTD PMID:22747577 NCBI chr27:36,088,754...36,143,581
Ensembl chr27:36,120,134...36,143,040 		JBrowse link
G CMTM7 CKLF like MARVEL transmembrane domain containing 7 increases expression EXP masitinib results in increased expression of CMTM7 mRNA CTD PMID:22747577 NCBI chr23:12,317,636...12,382,836
Ensembl chr23:12,328,303...12,382,837 		JBrowse link
G CORO1A coronin 1A increases expression EXP masitinib results in increased expression of CORO1A protein CTD PMID:22747577 NCBI chr 6:18,161,850...18,167,915
Ensembl chr 6:18,160,601...18,167,818 		JBrowse link
G CPNE1 copine 1 increases expression EXP masitinib results in increased expression of CPNE1 mRNA CTD PMID:22747577 NCBI chr24:24,554,636...24,589,748
Ensembl chr24:24,554,636...24,589,731 		JBrowse link
G CPNE6 copine 6 increases expression EXP masitinib results in increased expression of DHRS4 mRNA CTD PMID:22747577 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
G CTSK cathepsin K increases expression EXP masitinib results in increased expression of CTSK mRNA CTD PMID:22747577 NCBI chr17:59,928,725...59,938,293
Ensembl chr17:59,929,287...59,938,507 		JBrowse link
G DLA-12 MHC class I DLA-12 increases expression EXP masitinib results in increased expression of DLA-12 mRNA CTD PMID:22747577 NCBI chr12:933,321...936,671
Ensembl chr12:932,613...987,561 		JBrowse link
G DLA-64 MHC class I DLA-64 increases expression EXP masitinib results in increased expression of DLA-64 mRNA CTD PMID:22747577 NCBI chr12:983,573...986,969 JBrowse link
G DLGAP1 DLG associated protein 1 decreases expression EXP masitinib results in decreased expression of DLGAP1 mRNA CTD PMID:22747577 NCBI chr 7:70,082,563...70,949,116
Ensembl chr 7:70,081,885...70,406,213 		JBrowse link
G DLGAP5 DLG associated protein 5 decreases expression EXP masitinib results in decreased expression of DLGAP5 mRNA CTD PMID:22747577 NCBI chr 8:30,998,806...31,038,614
Ensembl chr 8:30,994,402...31,036,540 		JBrowse link
G DPCD deleted in primary ciliary dyskinesia homolog decreases expression EXP masitinib results in decreased expression of DPCD mRNA CTD PMID:22747577 NCBI chr28:14,201,302...14,219,121
Ensembl chr28:14,201,351...14,219,121 		JBrowse link
G DPYSL3 dihydropyrimidinase like 3 decreases expression EXP masitinib results in decreased expression of DPYSL3 mRNA CTD PMID:22747577 NCBI chr 2:41,687,725...41,809,402
Ensembl chr 2:41,690,845...41,802,376 		JBrowse link
G EBPL EBP like increases expression EXP masitinib results in increased expression of EBPL mRNA CTD PMID:22747577 NCBI chr22:2,116,588...2,137,935
Ensembl chr22:2,116,131...2,182,633 		JBrowse link
G EDEM2 ER degradation enhancing alpha-mannosidase like protein 2 increases expression EXP masitinib results in increased expression of EDEM2 mRNA CTD PMID:22747577 NCBI chr24:24,137,228...24,165,995
Ensembl chr24:24,137,228...24,165,968 		JBrowse link
G EIF3A eukaryotic translation initiation factor 3 subunit A decreases expression EXP masitinib results in decreased expression of EIF3A protein CTD PMID:22747577 NCBI chr28:29,290,668...29,326,851
Ensembl chr28:29,291,422...29,326,701 		JBrowse link
G EIF4A1 eukaryotic translation initiation factor 4A1 decreases expression EXP masitinib results in decreased expression of EIF4A1 protein CTD PMID:22747577 NCBI chr 5:32,495,606...32,500,805
Ensembl chr 5:32,484,572...32,500,805 		JBrowse link
G EIF5A2 eukaryotic translation initiation factor 5A2 decreases expression EXP masitinib results in decreased expression of EIF5A2 mRNA CTD PMID:22747577 NCBI chr34:35,309,812...35,322,382
Ensembl chr34:35,314,172...35,322,392 		JBrowse link
G ELSPBP1 epididymal sperm binding protein 1 increases expression EXP masitinib results in increased expression of ELSPBP1 mRNA CTD PMID:22747577 NCBI chr 1:108,159,609...108,187,224
Ensembl chr 1:108,159,611...108,188,076 		JBrowse link
G ETFDH electron transfer flavoprotein dehydrogenase decreases expression EXP masitinib results in decreased expression of ETFDH mRNA CTD PMID:22747577 NCBI chr15:55,752,170...55,781,118
Ensembl chr15:55,752,200...55,792,105 		JBrowse link
G GGT1 gamma-glutamyltransferase 1 increases expression EXP masitinib results in increased expression of GGT1 mRNA CTD PMID:22747577 NCBI chr26:28,301,455...28,315,029 JBrowse link
G GKN1 gastrokine 1 increases expression EXP masitinib results in increased expression of GKN1 mRNA CTD PMID:22747577 NCBI chr10:67,788,329...67,793,445
Ensembl chr10:67,788,110...67,793,589 		JBrowse link
G GMFB glia maturation factor beta decreases expression EXP masitinib results in decreased expression of GMFB mRNA CTD PMID:22747577 NCBI chr 8:30,394,020...30,408,408
Ensembl chr 8:30,359,499...30,408,357 		JBrowse link
G GSTA4 glutathione S-transferase alpha 4 increases expression EXP masitinib results in increased expression of GSTA4 mRNA CTD PMID:22747577 NCBI chr12:20,426,724...20,443,200
Ensembl chr12:20,426,726...20,443,200 		JBrowse link
G GXYLT1 glucoside xylosyltransferase 1 decreases expression EXP masitinib results in decreased expression of GXYLT1 mRNA CTD PMID:22747577 NCBI chr27:11,754,609...11,810,245
Ensembl chr27:11,765,072...11,807,787 		JBrowse link
G HEBP2 heme binding protein 2 decreases expression EXP masitinib results in decreased expression of HEBP2 mRNA CTD PMID:22747577 NCBI chr 1:30,716,395...30,724,814
Ensembl chr 1:30,716,606...30,724,613 		JBrowse link
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression EXP masitinib results in increased expression of HERPUD1 mRNA CTD PMID:22747577 NCBI chr 2:59,388,492...59,400,028
Ensembl chr 2:59,388,494...59,400,003 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP masitinib results in increased expression of HSP90B1 protein CTD PMID:22747577 NCBI chr15:42,456,793...42,474,122
Ensembl chr15:42,456,764...42,579,311 		JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B increases expression EXP masitinib results in increased expression of HTR2B mRNA CTD PMID:22747577 NCBI chr25:43,042,306...43,056,361
Ensembl chr25:43,042,173...43,056,612 		JBrowse link
G HYAL3 hyaluronidase 3 increases expression EXP masitinib results in increased expression of HYAL3 mRNA CTD PMID:22747577 NCBI chr20:39,041,940...39,047,388
Ensembl chr20:39,042,070...39,047,365 		JBrowse link
G IGFBP7 insulin like growth factor binding protein 7 increases expression EXP masitinib results in increased expression of IGFBP7 mRNA CTD PMID:22747577 NCBI chr13:49,138,406...49,207,235
Ensembl chr13:49,138,402...49,207,394 		JBrowse link
G IL13 interleukin 13 increases expression EXP masitinib results in increased expression of IL13 mRNA CTD PMID:22747577 NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388 		JBrowse link
G IMMP2L inner mitochondrial membrane peptidase subunit 2 increases expression EXP masitinib results in increased expression of IMMP2L mRNA CTD PMID:22747577 NCBI chr14:50,487,679...51,336,906 JBrowse link
G IRX6 iroquois homeobox 6 increases expression EXP masitinib results in increased expression of IRX6 protein CTD PMID:22747577 NCBI chr 2:60,630,688...60,636,285
Ensembl chr 2:60,630,447...60,636,416 		JBrowse link
G ITGA6 integrin subunit alpha 6 decreases expression EXP masitinib results in decreased expression of ITGA6 mRNA CTD PMID:22747577 NCBI chr36:16,777,363...16,858,725
Ensembl chr36:16,776,863...16,855,449 		JBrowse link
G JAML junction adhesion molecule like decreases expression EXP masitinib results in decreased expression of JAML mRNA CTD PMID:22747577 NCBI chr 5:15,485,378...15,513,457
Ensembl chr 5:15,476,582...15,513,075 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP masitinib results in increased expression of JUN mRNA CTD PMID:22747577 NCBI chr 5:50,966,698...50,968,939 JBrowse link
G KCTD19 potassium channel tetramerization domain containing 19 increases expression EXP masitinib results in increased expression of KCTD19 mRNA CTD PMID:22747577 NCBI chr 5:82,060,946...82,093,248
Ensembl chr 5:82,061,449...82,093,246 		JBrowse link
G KLHL5 kelch like family member 5 increases expression EXP masitinib results in increased expression of KLHL5 mRNA CTD PMID:22747577 NCBI chr 3:73,258,925...73,347,262
Ensembl chr 3:73,262,895...73,344,879 		JBrowse link
G LBX2 ladybird homeobox 2 increases expression EXP masitinib results in increased expression of LBX2 mRNA CTD PMID:22747577 NCBI chr17:48,641,630...48,643,411
Ensembl chr17:48,641,674...48,643,239 		JBrowse link
G LIN7C lin-7 homolog C, crumbs cell polarity complex component decreases expression EXP masitinib results in decreased expression of LIN7C mRNA CTD PMID:22747577 NCBI chr21:48,061,446...48,071,458
Ensembl chr21:48,064,929...48,071,429 		JBrowse link
G LOC474850 heat shock 70 kDa protein 1-like increases expression EXP masitinib results in increased expression of HSPA1L mRNA CTD PMID:22747577 NCBI chr12:1,281,164...1,285,010
Ensembl chr12:1,281,472...1,285,440 		JBrowse link
G LOC475707 GPN-loop GTPase 1 decreases expression EXP masitinib results in decreased expression of GPN1 mRNA CTD PMID:22747577 NCBI chr17:21,654,516...21,678,435
Ensembl chr17:21,545,673...21,673,157 		JBrowse link
G LOC478000 phytanoyl-CoA hydroxylase-like increases expression EXP masitinib results in increased expression of PHYH mRNA CTD PMID:22747577 NCBI chr 2:23,185,901...23,206,719
Ensembl chr 2:23,185,782...23,253,497 		JBrowse link
G LOC609402 hemoglobin subunit beta-like increases expression EXP masitinib results in increased expression of HBG1 mRNA CTD PMID:22747577 NCBI chr21:28,187,535...28,188,991 JBrowse link
G LONRF1 LON peptidase N-terminal domain and ring finger 1 increases expression EXP masitinib results in increased expression of LONRF1 mRNA CTD PMID:22747577 NCBI chr16:36,220,324...36,256,896
Ensembl chr16:36,221,156...36,256,897 		JBrowse link
G LRP1 LDL receptor related protein 1 increases expression EXP masitinib results in increased expression of LRP1 mRNA CTD PMID:22747577 NCBI chr10:1,260,256...1,341,705
Ensembl chr10:1,260,719...1,352,271 		JBrowse link
G LRP8 LDL receptor related protein 8 decreases expression EXP masitinib results in decreased expression of LRP8 mRNA CTD PMID:22747577 NCBI chr 5:55,604,878...55,684,666
Ensembl chr 5:55,604,878...55,699,736 		JBrowse link
G LYRM1 LYR motif containing 1 increases expression EXP masitinib results in increased expression of LYRM1 mRNA CTD PMID:22747577 NCBI chr 6:24,428,461...24,460,291
Ensembl chr 6:24,441,307...24,460,331 		JBrowse link
G MAGEF1 MAGE family member F1 decreases expression EXP masitinib results in decreased expression of MAGEF1 mRNA CTD PMID:22747577 NCBI chr34:17,543,381...17,545,089
Ensembl chr34:17,543,906...17,544,868 		JBrowse link
G MOB1B MOB kinase activator 1B decreases expression EXP masitinib results in decreased expression of MOB1B mRNA CTD PMID:22747577 NCBI chr13:60,145,168...60,197,916
Ensembl chr13:60,145,366...60,195,463 		JBrowse link
G MPDZ multiple PDZ domain crumbs cell polarity complex component increases expression EXP masitinib results in increased expression of MPDZ mRNA CTD PMID:22747577 NCBI chr11:33,691,434...33,826,500
Ensembl chr11:33,692,296...33,826,437 		JBrowse link
G MYOZ1 myozenin 1 increases expression EXP masitinib results in increased expression of MYOZ1 mRNA CTD PMID:22747577 NCBI chr 4:24,158,532...24,165,416
Ensembl chr 4:24,158,720...24,165,392 		JBrowse link
G NAPG NSF attachment protein gamma decreases expression EXP masitinib results in decreased expression of NAPG mRNA CTD PMID:22747577 NCBI chr 7:76,403,561...76,424,994
Ensembl chr 7:76,403,595...76,423,170 		JBrowse link
G NDUFS1 NADH:ubiquinone oxidoreductase core subunit S1 decreases expression EXP masitinib results in decreased expression of NDUFS1 mRNA CTD PMID:22747577 NCBI chr37:14,680,908...14,713,838
Ensembl chr37:14,683,083...14,713,754 		JBrowse link
G NFKBIA NFKB inhibitor alpha increases expression EXP masitinib results in increased expression of NFKBIA mRNA CTD PMID:22747577 NCBI chr 8:14,100,203...14,103,453
Ensembl chr 8:14,100,671...14,103,433 		JBrowse link
G NRAS NRAS proto-oncogene, GTPase decreases expression EXP masitinib results in decreased expression of NRAS mRNA CTD PMID:22747577 NCBI chr17:52,411,733...52,418,788
Ensembl chr17:52,411,733...52,418,788 		JBrowse link
G NSG1 neuronal vesicle trafficking associated 1 decreases expression EXP masitinib results in decreased expression of NSG1 mRNA CTD PMID:22747577 NCBI chr 3:69,805,646...69,831,200
Ensembl chr 3:69,805,592...69,831,194 		JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 increases expression EXP masitinib results in increased expression of NTRK1 mRNA CTD PMID:22747577 NCBI chr 7:41,140,931...41,159,326
Ensembl chr 7:41,140,879...41,159,288 		JBrowse link
G OCA2 OCA2 melanosomal transmembrane protein decreases expression EXP masitinib results in decreased expression of OCA2 mRNA CTD PMID:22747577 NCBI chr 3:32,361,825...32,713,631
Ensembl chr 3:32,361,517...32,713,572 		JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase increases expression EXP masitinib results in increased expression of OGT mRNA CTD PMID:22747577 NCBI chr  X:55,821,227...55,857,597
Ensembl chr  X:55,821,234...55,855,502 		JBrowse link
G OXCT1 3-oxoacid CoA-transferase 1 increases expression EXP masitinib results in increased expression of OXCT1 protein CTD PMID:22747577 NCBI chr 4:67,709,846...67,841,737
Ensembl chr 4:67,527,531...67,841,518 		JBrowse link
G PARP14 poly(ADP-ribose) polymerase family member 14 increases expression EXP masitinib results in increased expression of PARP14 mRNA CTD PMID:22747577 NCBI chr33:25,763,282...25,798,284
Ensembl chr33:25,763,255...25,798,198 		JBrowse link
G PCM1 pericentriolar material 1 increases expression EXP masitinib results in increased expression of PCM1 mRNA CTD PMID:22747577 NCBI chr16:41,212,733...41,291,654
Ensembl chr16:41,214,417...41,291,376 		JBrowse link
G PCOLCE2 procollagen C-endopeptidase enhancer 2 decreases expression EXP masitinib results in decreased expression of PCOLCE2 mRNA CTD PMID:22747577 NCBI chr23:38,424,408...38,486,800
Ensembl chr23:38,426,216...38,487,252 		JBrowse link
G PDE6H phosphodiesterase 6H increases expression EXP masitinib results in increased expression of PDE6H mRNA CTD PMID:22747577 NCBI chr27:31,640,731...31,664,494
Ensembl chr27:31,640,737...31,664,401 		JBrowse link
G PDHA1 pyruvate dehydrogenase E1 subunit alpha 1 decreases expression EXP masitinib results in decreased expression of PDHA1 mRNA CTD PMID:22747577 NCBI chr  X:15,338,364...15,354,011
Ensembl chr  X:15,338,202...15,387,458 		JBrowse link
G PDIA3 protein disulfide isomerase family A member 3 increases expression EXP masitinib results in increased expression of PDIA3 protein CTD PMID:22747577 NCBI chr30:10,487,926...10,513,437
Ensembl chr30:10,487,921...10,513,397 		JBrowse link
G PEBP4 phosphatidylethanolamine binding protein 4 increases expression EXP masitinib results in increased expression of PEBP4 mRNA CTD PMID:22747577 NCBI chr25:34,329,160...34,574,086
Ensembl chr25:34,317,421...34,574,066 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 increases expression EXP masitinib results in increased expression of PECAM1 mRNA CTD PMID:22747577 NCBI chr 9:12,166,124...12,219,553
Ensembl chr 9:12,166,775...12,219,778 		JBrowse link
G PHF10 PHD finger protein 10 increases expression EXP masitinib results in increased expression of PHF10 mRNA CTD PMID:22747577 NCBI chr12:71,955,354...71,998,283
Ensembl chr12:71,787,082...71,998,243 		JBrowse link
G POMT1 protein O-mannosyltransferase 1 decreases expression EXP masitinib results in decreased expression of POMT1 mRNA CTD PMID:22747577 NCBI chr 9:52,615,349...52,631,538
Ensembl chr 9:52,615,655...52,630,836 		JBrowse link
G POR cytochrome p450 oxidoreductase increases expression EXP masitinib results in increased expression of POR mRNA CTD PMID:22747577 NCBI chr 6:7,247,780...7,316,282
Ensembl chr 6:7,263,574...7,316,297 		JBrowse link
G PPA1 inorganic pyrophosphatase 1 decreases expression EXP masitinib results in decreased expression of PPA1 protein CTD PMID:22747577 NCBI chr 4:21,145,547...21,189,985
Ensembl chr 4:21,145,547...21,182,748 		JBrowse link
G PRPS2 phosphoribosyl pyrophosphate synthetase 2 decreases expression EXP masitinib results in decreased expression of PRPS2 mRNA CTD PMID:22747577 NCBI chr  X:9,281,686...9,326,551
Ensembl chr  X:9,281,730...9,418,289 		JBrowse link
G PSMB9 proteasome 20S subunit beta 9 increases expression EXP masitinib results in increased expression of PSMB9 mRNA CTD PMID:22747577 NCBI chr12:2,432,287...2,438,920
Ensembl chr12:2,432,505...2,438,069 		JBrowse link
G PSMD6 proteasome 26S subunit, non-ATPase 6 decreases expression EXP masitinib results in decreased expression of PSMD6 protein CTD PMID:22747577 NCBI chr20:27,206,801...27,220,059 JBrowse link
G PSMD9 proteasome 26S subunit, non-ATPase 9 decreases expression EXP masitinib results in decreased expression of PSMD9 mRNA CTD PMID:22747577 NCBI chr26:7,376,154...7,400,655
Ensembl chr26:7,377,413...7,400,573 		JBrowse link
G PTH parathyroid hormone increases expression EXP masitinib results in increased expression of PTH mRNA CTD PMID:22747577 NCBI chr21:36,417,062...36,419,967
Ensembl chr21:36,417,058...36,419,967 		JBrowse link
G PXYLP1 2-phosphoxylose phosphatase 1 decreases expression EXP masitinib results in decreased expression of ACPL2 mRNA CTD PMID:22747577 NCBI chr23:37,145,065...37,197,808
Ensembl chr23:37,145,086...37,196,427 		JBrowse link
G R3HDM2 R3H domain containing 2 increases expression EXP masitinib results in increased expression of R3HDM2 mRNA CTD PMID:22747577 NCBI chr10:1,377,664...1,504,008
Ensembl chr10:1,370,350...1,504,017 		JBrowse link
G RAB44 RAB44, member RAS oncogene family increases expression EXP masitinib results in increased expression of RAB44 mRNA CTD PMID:22747577 NCBI chr12:5,769,056...5,804,963
Ensembl chr12:5,770,882...5,804,949 		JBrowse link
G RASGRP2 RAS guanyl releasing protein 2 increases expression EXP masitinib results in increased expression of RASGRP2 mRNA CTD PMID:22747577 NCBI chr18:52,412,331...52,426,910
Ensembl chr18:52,412,367...52,426,916 		JBrowse link
G RCAN1 regulator of calcineurin 1 increases expression EXP masitinib results in increased expression of RCAN1 mRNA CTD PMID:22747577 NCBI chr31:29,908,046...30,002,412
Ensembl chr31:29,909,388...30,002,418 		JBrowse link
G RGS13 regulator of G protein signaling 13 decreases expression EXP masitinib results in decreased expression of RGS13 mRNA CTD PMID:22747577 NCBI chr38:6,291,146...6,316,662
Ensembl chr38:6,291,182...6,315,198 		JBrowse link
G SAR1B secretion associated Ras related GTPase 1B decreases expression EXP masitinib results in decreased expression of SAR1A mRNA CTD PMID:22747577 NCBI chr11:22,713,459...22,743,190
Ensembl chr11:22,717,942...22,743,124 		JBrowse link
G SCD stearoyl-CoA desaturase decreases expression EXP masitinib results in decreased expression of SCD mRNA CTD PMID:22747577 NCBI chr28:13,112,741...13,129,129
Ensembl chr28:13,113,006...13,125,801 		JBrowse link
G SELENBP1 selenium binding protein 1 increases expression EXP masitinib results in increased expression of SELENBP1 protein CTD PMID:22747577 NCBI chr17:60,410,727...60,418,770
Ensembl chr17:60,410,734...60,418,704 		JBrowse link
G SERPINE2 serpin family E member 2 increases expression EXP masitinib results in increased expression of SERPINE2 mRNA CTD PMID:22747577 NCBI chr37:29,699,551...29,750,151
Ensembl chr37:29,700,024...29,724,228 		JBrowse link
G SFT2D2 SFT2 domain containing 2 decreases expression EXP masitinib results in decreased expression of SFT2D2 mRNA CTD PMID:22747577 NCBI chr 7:30,258,748...30,281,371 JBrowse link
G SLA Src like adaptor increases expression EXP masitinib results in increased expression of SLA mRNA CTD PMID:22747577 NCBI chr13:29,503,304...29,590,679
Ensembl chr13:29,504,867...29,569,773 		JBrowse link
G SLC25A12 solute carrier family 25 member 12 decreases expression EXP masitinib results in decreased expression of SLC25A12 mRNA CTD PMID:22747577 NCBI chr36:16,185,011...16,391,080
Ensembl chr36:16,185,649...16,483,016 		JBrowse link
G SMC5 structural maintenance of chromosomes 5 decreases expression EXP masitinib results in decreased expression of SMC5 mRNA CTD PMID:22747577 NCBI chr 1:87,192,988...87,285,678
Ensembl chr 1:87,194,867...87,285,606 		JBrowse link
G SRR serine racemase increases expression EXP masitinib results in increased expression of SRR mRNA CTD PMID:22747577
G STING1 stimulator of interferon response cGAMP interactor 1 increases expression EXP masitinib results in increased expression of TMEM173 mRNA CTD PMID:22747577 NCBI chr 2:34,783,947...34,792,204
Ensembl chr 2:34,784,232...34,789,072 		JBrowse link
G STOX1 storkhead box 1 increases expression EXP masitinib results in increased expression of STOX1 mRNA CTD PMID:22747577 NCBI chr 4:20,013,893...20,065,480
Ensembl chr 4:20,014,007...20,060,394 		JBrowse link
G STX16 syntaxin 16 increases expression EXP masitinib results in increased expression of STX16 mRNA CTD PMID:22747577 NCBI chr24:43,425,719...43,451,828
Ensembl chr24:43,426,470...43,449,077 		JBrowse link
G STYXL1 serine/threonine/tyrosine interacting like 1 increases expression EXP masitinib results in increased expression of STYXL1 mRNA CTD PMID:22747577 NCBI chr 6:7,323,911...7,389,878
Ensembl chr 6:7,316,477...7,389,842 		JBrowse link
G TARDBP TAR DNA binding protein decreases expression EXP masitinib results in decreased expression of TARDBP protein CTD PMID:22747577 NCBI chr 2:84,987,752...84,998,136
Ensembl chr 2:84,989,952...84,998,593 		JBrowse link
G TBC1D14 TBC1 domain family member 14 decreases expression EXP masitinib results in decreased expression of TBC1D14 mRNA CTD PMID:22747577 NCBI chr 3:58,992,743...59,097,581
Ensembl chr 3:58,926,237...59,097,621 		JBrowse link
G TCN2 transcobalamin 2 increases expression EXP masitinib results in increased expression of TCN2 mRNA CTD PMID:22747577 NCBI chr26:23,693,664...23,710,342
Ensembl chr26:23,693,773...23,709,832 		JBrowse link
G TCP1 t-complex 1 decreases expression EXP masitinib results in decreased expression of TCP1 protein CTD PMID:22747577 NCBI chr 1:49,029,260...49,038,023
Ensembl chr 1:49,029,282...49,038,020 		JBrowse link
G TEAD4 TEA domain transcription factor 4 increases expression EXP masitinib results in increased expression of TEAD4 mRNA CTD PMID:22747577 NCBI chr27:41,744,100...41,783,223
Ensembl chr27:41,748,871...41,803,556 		JBrowse link
G THEMIS2 thymocyte selection associated family member 2 decreases expression EXP masitinib results in decreased expression of THEMIS2 mRNA CTD PMID:22747577 NCBI chr 2:72,465,719...72,501,962
Ensembl chr 2:72,464,026...72,502,928 		JBrowse link
G TM2D2 TM2 domain containing 2 increases expression EXP masitinib results in increased expression of TM2D2 mRNA CTD PMID:22747577 NCBI chr16:26,551,563...26,557,554
Ensembl chr16:26,551,628...26,556,285 		JBrowse link
G TMEM108 transmembrane protein 108 increases expression EXP masitinib results in increased expression of TMEM108 mRNA CTD PMID:22747577 NCBI chr23:29,992,038...30,331,791
Ensembl chr23:29,992,021...30,396,840 		JBrowse link
G TMEM260 transmembrane protein 260 increases expression EXP masitinib results in increased expression of TMEM260 mRNA CTD PMID:22747577 NCBI chr 8:32,238,992...32,309,320
Ensembl chr 8:32,238,988...32,306,317 		JBrowse link
G TNFSF10 TNF superfamily member 10 increases expression EXP masitinib results in increased expression of TNFSF10 mRNA CTD PMID:22747577 NCBI chr34:36,719,249...36,734,989
Ensembl chr34:36,670,849...36,735,060 		JBrowse link
G TNPO1 transportin 1 decreases expression EXP masitinib results in decreased expression of TNPO1 mRNA CTD PMID:22747577 NCBI chr 2:55,795,737...55,859,366
Ensembl chr 2:55,799,907...55,851,213 		JBrowse link
G TNS1 tensin 1 decreases expression EXP masitinib results in decreased expression of TNS1 mRNA CTD PMID:22747577 NCBI chr37:24,578,855...24,776,153
Ensembl chr37:24,581,806...24,808,049 		JBrowse link
G TOX thymocyte selection associated high mobility group box increases expression EXP masitinib results in increased expression of TOX mRNA CTD PMID:22747577 NCBI chr29:9,542,471...9,841,759
Ensembl chr29:9,544,561...9,842,034 		JBrowse link
G TSHB thyroid stimulating hormone subunit beta increases expression EXP masitinib results in increased expression of TSHB mRNA CTD PMID:22747577 NCBI chr17:52,659,137...52,685,388
Ensembl chr17:52,681,357...52,685,390 		JBrowse link
G TSPAN2 tetraspanin 2 increases expression EXP masitinib results in increased expression of TSPAN2 mRNA CTD PMID:22747577 NCBI chr17:52,692,744...52,749,048
Ensembl chr17:52,694,603...52,744,276 		JBrowse link
G TTC38 tetratricopeptide repeat domain 38 increases expression EXP masitinib results in increased expression of TTC38 protein CTD PMID:22747577 NCBI chr10:19,887,285...19,910,347
Ensembl chr10:19,773,373...19,910,683 		JBrowse link
G TTLL1 TTL family tubulin polyglutamylase complex subunit L1 decreases expression EXP masitinib results in decreased expression of TTLL1 mRNA CTD PMID:22747577 NCBI chr10:22,456,150...22,492,375
Ensembl chr10:22,456,146...22,488,505 		JBrowse link
G UCHL3 ubiquitin C-terminal hydrolase L3 increases expression EXP masitinib results in increased expression of UCHL3 protein CTD PMID:22747577 NCBI chr22:29,348,962...29,397,944
Ensembl chr22:29,348,706...29,407,965 		JBrowse link
G UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 decreases expression EXP masitinib results in decreased expression of UQCC mRNA CTD PMID:22747577 NCBI chr24:24,285,147...24,381,819
Ensembl chr24:24,286,320...24,381,699 		JBrowse link
G UROD uroporphyrinogen decarboxylase increases expression EXP masitinib results in increased expression of UROD protein CTD PMID:22747577 NCBI chr15:15,313,808...15,317,130
Ensembl chr15:15,312,674...15,320,010 		JBrowse link
G UROS uroporphyrinogen III synthase increases expression EXP masitinib results in increased expression of UROS mRNA CTD PMID:22747577 NCBI chr28:34,952,074...34,983,532
Ensembl chr28:34,948,003...34,983,532 		JBrowse link
G VCPKMT valosin containing protein lysine methyltransferase decreases expression EXP masitinib results in decreased expression of VCPKMT mRNA CTD PMID:22747577 NCBI chr 8:26,611,333...26,636,700
Ensembl chr 8:26,625,677...26,636,316 		JBrowse link
G WAPL WAPL cohesin release factor decreases expression EXP masitinib results in decreased expression of WAPAL mRNA CTD PMID:22747577 NCBI chr 4:34,219,644...34,297,456
Ensembl chr 4:34,219,645...34,302,839 		JBrowse link
G YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta increases expression EXP masitinib results in increased expression of YWHAZ protein CTD PMID:22747577 NCBI chr13:2,729,404...2,764,422 JBrowse link
G ZNF23 zinc finger protein 23 increases expression EXP masitinib results in increased expression of ZNF23 mRNA CTD PMID:22747577 NCBI chr 5:77,246,374...77,260,761
Ensembl chr 5:77,246,667...77,260,350 		JBrowse link
mastoparan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNAQ G protein subunit alpha q multiple interactions EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]; ganglioside, GD1a inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]; mastoparan results in increased activity of and affects the localization of GNAQ protein CTD PMID:21671308 NCBI chr 1:80,733,530...80,928,065
Ensembl chr 1:80,715,366...80,928,065 		JBrowse link
G HEXB hexosaminidase subunit beta multiple interactions
increases secretion		 EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; ganglioside, GD1a inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein]; methyl-beta-cyclodextrin promotes the reaction [mastoparan results in increased secretion of HEXB protein]; Pertussis Toxin inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; Quinacrine promotes the reaction [mastoparan results in increased secretion of HEXB protein]; YM-254890 inhibits the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417 		JBrowse link
melittin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions
increases secretion		 EXP G(M1) Ganglioside inhibits the reaction [Melitten results in increased secretion of HEXB protein]; sialogangliosides inhibits the reaction [Melitten results in increased secretion of HEXB protein]; trisialoganglioside GT1 inhibits the reaction [Melitten results in increased secretion of HEXB protein] CTD PMID:21334356 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417 		JBrowse link
menadione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CPNE6 copine 6 increases reduction EXP DHRS4 protein results in increased reduction of Vitamin K 3 CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
metamizole sodium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Dipyrone results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
methyl beta-cyclodextrin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions EXP methyl-beta-cyclodextrin promotes the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417 		JBrowse link
metoprolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of ATP2A2 protein CTD PMID:18820026 NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388 		JBrowse link
G CYP2D15 cytochrome P450 family 2 subfamily D member 15 affects metabolic processing EXP CYP2D15 affects the metabolism of Metoprolol CTD PMID:7786018 NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298 		JBrowse link
G EGR1 early growth response 1 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of EGR1 protein CTD PMID:18820026 NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575 		JBrowse link
G GATA4 GATA binding protein 4 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein CTD PMID:18820026 NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989 		JBrowse link
G NAB1 NGFI-A binding protein 1 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of NAB1 protein CTD PMID:18820026 NCBI chr37:1,207,619...1,243,546
Ensembl chr37:1,207,638...1,241,610 		JBrowse link
G SLC8A1 solute carrier family 8 member A1 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein CTD PMID:18820026 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700 		JBrowse link
mexiletine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases response to substance EXP ABCB1 mutant form results in increased susceptibility to Mexiletine CTD PMID:16594604 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
milbemycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases response to substance
multiple interactions		 EXP ABCB1 gene mutant form results in increased susceptibility to moxidectin; ABCB1 mutant form results in increased susceptibility to moxidectin
ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of ALB mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of DAO mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of EBF3 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of GABRQ mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of GLRA1 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of KLK6 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of MAB21L2 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of SLC10A4 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of SLC18A2 mRNA]; ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of TTR mRNA]		 CTD PMID:23186803 PMID:25419811 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G ALB albumin multiple interactions EXP ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of ALB mRNA] CTD PMID:25419811 NCBI chr13:62,133,747...62,169,349
Ensembl chr13:62,053,814...62,294,709 		JBrowse link
G DAO D-amino acid oxidase multiple interactions EXP ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of DAO mRNA] CTD PMID:25419811 NCBI chr26:18,032,663...18,057,277
Ensembl chr26:18,033,392...18,057,238 		JBrowse link
G EBF3 EBF transcription factor 3 multiple interactions EXP ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of EBF3 mRNA] CTD PMID:25419811 NCBI chr28:38,489,635...38,601,800
Ensembl chr28:38,491,047...38,602,022 		JBrowse link
G GABRQ gamma-aminobutyric acid type A receptor subunit theta multiple interactions EXP ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of GABRQ mRNA] CTD PMID:25419811 NCBI chr  X:120,607,815...120,630,251
Ensembl chr  X:120,607,686...120,628,343 		JBrowse link
G GLRA1 glycine receptor alpha 1 multiple interactions EXP ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of GLRA1 mRNA] CTD PMID:25419811 NCBI chr 4:57,443,094...57,541,494
Ensembl chr 4:57,443,999...57,528,376 		JBrowse link
G KLK6 kallikrein related peptidase 6 multiple interactions EXP ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of KLK6 mRNA] CTD PMID:25419811 NCBI chr 1:105,902,147...105,907,585 JBrowse link
G MAB21L2 mab-21 like 2 multiple interactions EXP ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of MAB21L2 mRNA] CTD PMID:25419811 NCBI chr15:48,538,912...48,541,651
Ensembl chr15:48,539,955...48,541,034 		JBrowse link
G SLC10A4 solute carrier family 10 member 4 multiple interactions EXP ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of SLC10A4 mRNA] CTD PMID:25419811 NCBI chr13:44,293,956...44,299,529
Ensembl chr13:44,277,094...44,299,732 		JBrowse link
G SLC18A2 solute carrier family 18 member A2 multiple interactions EXP ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of SLC18A2 mRNA] CTD PMID:25419811 NCBI chr28:27,731,709...27,809,341
Ensembl chr28:27,731,004...27,767,993 		JBrowse link
G TTR transthyretin multiple interactions EXP ABCB1 gene mutant form affects the reaction [moxidectin affects the expression of TTR mRNA] CTD PMID:25419811 NCBI chr 7:57,940,354...57,947,084
Ensembl chr 7:57,914,381...57,947,058 		JBrowse link
ML-7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin] CTD PMID:20510202 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G MYLK myosin light chain kinase multiple interactions EXP [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin] CTD PMID:20510202 NCBI chr33:26,663,991...26,867,370
Ensembl chr33:26,664,800...26,843,181 		JBrowse link
mocetinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKAP12 A-kinase anchoring protein 12 increases expression EXP mocetinostat results in increased expression of AKAP12 mRNA CTD PMID:27255383 NCBI chr 1:41,614,893...41,712,350
Ensembl chr 1:41,614,714...41,709,798 		JBrowse link
G ANK1 ankyrin 1 decreases expression EXP mocetinostat results in decreased expression of ANK1 mRNA CTD PMID:27255383 NCBI chr16:23,858,299...23,966,181
Ensembl chr16:23,766,193...23,964,226 		JBrowse link
G ANK3 ankyrin 3 increases expression EXP mocetinostat results in increased expression of ANK3 mRNA CTD PMID:27255383 NCBI chr 4:12,166,275...12,827,175
Ensembl chr 4:12,167,550...12,827,037 		JBrowse link
G AP2M1 adaptor related protein complex 2 subunit mu 1 decreases expression EXP mocetinostat results in decreased expression of AP2M1 mRNA CTD PMID:27255383 NCBI chr34:17,071,199...17,080,445
Ensembl chr34:17,071,235...17,080,445 		JBrowse link
G AP2S1 adaptor related protein complex 2 subunit sigma 1 decreases expression EXP mocetinostat results in decreased expression of AP2S1 mRNA CTD PMID:27255383 NCBI chr 1:109,094,098...109,105,233
Ensembl chr 1:109,082,221...109,105,230 		JBrowse link
G AP3S1 adaptor related protein complex 3 subunit sigma 1 increases expression EXP mocetinostat results in increased expression of AP3S1 mRNA CTD PMID:27255383 NCBI chr11:5,543,140...5,611,322
Ensembl chr11:5,543,222...5,610,930 		JBrowse link
G ARF4 ADP ribosylation factor 4 increases expression EXP mocetinostat results in increased expression of ARF4 mRNA CTD PMID:27255383 NCBI chr20:32,849,725...32,871,127
Ensembl chr20:32,849,757...32,870,721 		JBrowse link
G ATG4D autophagy related 4D cysteine peptidase decreases expression EXP mocetinostat results in decreased expression of ATG4D mRNA CTD PMID:27255383 NCBI chr20:50,618,458...50,623,703
Ensembl chr20:50,618,459...50,624,179 		JBrowse link
G ATG7 autophagy related 7 decreases expression EXP mocetinostat results in decreased expression of ATG7 mRNA CTD PMID:27255383 NCBI chr20:6,916,354...7,154,849
Ensembl chr20:6,916,515...7,154,800 		JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 increases expression EXP mocetinostat results in increased expression of ATP1A1 mRNA CTD PMID:27255383 NCBI chr17:53,828,482...53,847,043
Ensembl chr17:53,813,976...53,847,167 		JBrowse link
G BCAP29 B cell receptor associated protein 29 increases expression EXP mocetinostat results in increased expression of BCAP29 mRNA CTD PMID:27255383 NCBI chr18:12,969,594...13,021,948
Ensembl chr18:12,970,411...13,022,022 		JBrowse link
G BLOC1S1 biogenesis of lysosomal organelles complex 1 subunit 1 decreases expression EXP mocetinostat results in decreased expression of BLOC1S1 mRNA CTD PMID:27255383 NCBI chr10:116,993...120,244 JBrowse link
G BNIP1 BCL2 interacting protein 1 decreases expression EXP mocetinostat results in decreased expression of BNIP1 mRNA CTD PMID:27255383 NCBI chr 4:39,255,685...39,303,485
Ensembl chr 4:39,289,776...39,303,430 		JBrowse link
G CACNB3 calcium voltage-gated channel auxiliary subunit beta 3 increases expression EXP mocetinostat results in increased expression of CACNB3 mRNA CTD PMID:27255383 NCBI chr27:5,705,587...5,714,620
Ensembl chr27:5,706,064...5,717,647 		JBrowse link
G CAMK1D calcium/calmodulin dependent protein kinase ID increases expression EXP mocetinostat results in increased expression of CAMK1D mRNA CTD PMID:27255383 NCBI chr 2:23,680,395...24,113,922
Ensembl chr 2:23,685,672...24,114,084 		JBrowse link
G CASK calcium/calmodulin dependent serine protein kinase increases expression EXP mocetinostat results in increased expression of CASK mRNA CTD PMID:27255383 NCBI chr  X:35,939,117...36,296,438
Ensembl chr  X:35,940,647...36,297,014 		JBrowse link
G CAV1 caveolin 1 increases expression EXP mocetinostat results in increased expression of CAV1 mRNA CTD PMID:27255383 NCBI chr14:55,458,934...55,494,563
Ensembl chr14:55,461,048...55,492,935 		JBrowse link
G CBY1 chibby 1, beta catenin antagonist decreases expression EXP mocetinostat results in decreased expression of CBY1 mRNA CTD PMID:27255383 NCBI chr10:26,125,064...26,134,693
Ensembl chr10:26,125,189...26,128,285 		JBrowse link
G CHMP4B charged multivesicular body protein 4B decreases expression EXP mocetinostat results in decreased expression of CHMP4B mRNA CTD PMID:27255383 NCBI chr24:22,995,677...23,050,084
Ensembl chr24:22,995,672...23,049,287 		JBrowse link
G CHMP5 charged multivesicular body protein 5 decreases expression EXP mocetinostat results in decreased expression of CHMP5 mRNA CTD PMID:27255383 NCBI chr11:50,363,488...50,376,081 JBrowse link
G CHMP6 charged multivesicular body protein 6 decreases expression EXP mocetinostat results in decreased expression of CHMP6 mRNA CTD PMID:27255383 NCBI chr 9:997,951...1,001,659
Ensembl chr 9:998,653...1,002,538 		JBrowse link
G CLTCL1 clathrin heavy chain like 1 increases expression EXP mocetinostat results in increased expression of CLTCL1 mRNA CTD PMID:27255383 NCBI chr26:29,907,235...30,002,136
Ensembl chr26:29,906,278...30,002,128 		JBrowse link
G COPB1 COPI coat complex subunit beta 1 increases expression EXP mocetinostat results in increased expression of COPB1 mRNA CTD PMID:27255383 NCBI chr21:37,186,380...37,224,549
Ensembl chr21:37,186,424...37,224,519 		JBrowse link
G COPB2 COPI coat complex subunit beta 2 decreases expression EXP mocetinostat results in decreased expression of COPB2 mRNA CTD PMID:27255383 NCBI chr23:35,536,520...35,604,708
Ensembl chr23:35,536,615...35,566,569 		JBrowse link
G COPG1 COPI coat complex subunit gamma 1 decreases expression EXP mocetinostat results in decreased expression of COPG1 mRNA CTD PMID:27255383 NCBI chr20:2,832,150...2,860,356
Ensembl chr20:2,832,198...2,860,320 		JBrowse link
G DERL2 derlin 2 decreases expression EXP mocetinostat results in decreased expression of DERL2 mRNA CTD PMID:27255383 NCBI chr 5:31,319,660...31,330,846
Ensembl chr 5:31,319,717...31,330,841 		JBrowse link
G DNM1L dynamin 1 like decreases expression EXP mocetinostat results in decreased expression of DNM1L mRNA CTD PMID:27255383 NCBI chr27:16,161,855...16,211,983
Ensembl chr27:16,163,357...16,211,957 		JBrowse link
G GPAA1 glycosylphosphatidylinositol anchor attachment 1 decreases expression EXP mocetinostat results in decreased expression of GPAA1 mRNA CTD PMID:27255383 NCBI chr13:37,577,162...37,580,346
Ensembl chr13:37,576,354...37,580,345 		JBrowse link
G HPS4 HPS4 biogenesis of lysosomal organelles complex 3 subunit 2 decreases expression EXP mocetinostat results in decreased expression of HPS4 mRNA CTD PMID:27255383 NCBI chr26:20,131,658...20,157,532
Ensembl chr26:19,933,281...20,157,058 		JBrowse link
G HRC histidine rich calcium binding protein decreases expression EXP mocetinostat results in decreased expression of HRC mRNA CTD PMID:27255383 NCBI chr 1:107,304,718...107,308,741
Ensembl chr 1:107,304,924...107,308,740 		JBrowse link
G KCNK1 potassium two pore domain channel subfamily K member 1 increases expression EXP mocetinostat results in increased expression of KCNK1 mRNA CTD PMID:27255383 NCBI chr 4:6,117,406...6,139,390
Ensembl chr 4:6,118,373...6,122,093 		JBrowse link
G KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 increases expression EXP mocetinostat results in increased expression of KCNMB4 mRNA CTD PMID:27255383 NCBI chr10:12,211,372...12,251,739 JBrowse link
G KCNS3 potassium voltage-gated channel modifier subfamily S member 3 increases expression EXP mocetinostat results in increased expression of KCNS3 mRNA CTD PMID:27255383 NCBI chr17:13,297,242...13,338,319
Ensembl chr17:13,336,374...13,337,849 		JBrowse link
G KIF5A kinesin family member 5A increases expression EXP mocetinostat results in increased expression of KIF5A mRNA CTD PMID:27255383 NCBI chr10:1,637,007...1,666,790
Ensembl chr10:1,636,932...1,664,767 		JBrowse link
G KIF5B kinesin family member 5B decreases expression EXP mocetinostat results in decreased expression of KIF5B mRNA CTD PMID:27255383 NCBI chr 2:14,835,906...14,880,896
Ensembl chr 2:14,835,901...14,878,251 		JBrowse link
G KIF5C kinesin family member 5C increases expression EXP mocetinostat results in increased expression of KIF5C mRNA CTD PMID:27255383 NCBI chr19:50,535,622...50,684,485
Ensembl chr19:50,535,456...50,668,738 		JBrowse link
G LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 decreases expression EXP mocetinostat results in decreased expression of LAMTOR1 mRNA CTD PMID:27255383 NCBI chr21:25,981,170...25,986,942
Ensembl chr21:25,981,254...25,996,432 		JBrowse link
G LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 decreases expression EXP mocetinostat results in decreased expression of LAMTOR2 mRNA CTD PMID:27255383 NCBI chr 7:41,760,632...41,764,926
Ensembl chr 7:41,760,638...41,763,299 		JBrowse link
G LOC478702 tubulin beta-2B chain increases expression EXP mocetinostat results in increased expression of TUBB2B mRNA