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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:pnictogen molecular entity
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Accession:CHEBI:33302 term browser browse the term
Definition:A p-block molecular entity containing any pnictogen.
Synonyms:related_synonym: pnictogen molecular entities


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(R)-adrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NPPA natriuretic peptide A affects abundance EXP NPPA protein affects the abundance of Epinephrine CTD PMID:2951327 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
JBrowse link
(R)-noradrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 increases activity EXP Norepinephrine results in increased activity of ADRB1 protein CTD PMID:10344530 NCBI chr28:24,908,224...24,909,684
Ensembl chr28:24,908,224...24,909,684
JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP [Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine CTD PMID:2884805 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298
JBrowse link
G NPPA natriuretic peptide A increases expression EXP Norepinephrine results in increased expression of NPPA protein CTD PMID:8952593 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions
increases activity
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of PIK3CG protein]; [Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
JBrowse link
G POMC proopiomelanocortin increases response to substance EXP POMC protein results in increased susceptibility to Norepinephrine CTD PMID:6279499 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664
JBrowse link
G REN renin increases activity EXP Norepinephrine results in increased activity of REN protein CTD PMID:8952593 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 decreases activity
multiple interactions
EXP 1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein
dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]
CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714
JBrowse link
1,4-phenylenediamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP8 caspase 8 increases activity
multiple interactions
EXP 4-phenylenediamine results in increased activity of CASP8 protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [4-phenylenediamine results in increased activity of CASP8 protein]
CTD PMID:20156547 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822
JBrowse link
G CASP9 caspase 9 multiple interactions
increases activity
EXP benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [4-phenylenediamine results in increased activity of CASP9 protein] CTD PMID:20156547 NCBI chr 2:82,033,759...82,076,710
Ensembl chr 2:82,031,563...82,090,484
JBrowse link
1-stearoyl-2-arachidonoylphosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP 1-stearoyl-2-arachidonoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714
JBrowse link
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP [Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin CTD PMID:20510202 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
3',5'-cyclic AMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions EXP [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059
JBrowse link
3'-CMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions EXP [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate CTD PMID:2579070 NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653
JBrowse link
3-isobutyl-1-methyl-7H-xanthine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator multiple interactions EXP [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein CTD PMID:15161604 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977
JBrowse link
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions EXP Cisapride binds to and results in decreased activity of KCNH2 protein CTD PMID:12388285 NCBI chr16:15,009,031...15,041,786
Ensembl chr16:15,009,031...15,041,504
JBrowse link
4-nitrophenyl phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPI alkaline phosphatase, intestinal increases chemical synthesis EXP ALPI protein results in increased chemical synthesis of nitrophenylphosphate CTD PMID:1495895 NCBI chr25:44,107,418...44,110,947 JBrowse link
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions EXP pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059
JBrowse link
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Omeprazole results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
JBrowse link
5-Nitro-2-(3-phenylpropylamino)benzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator decreases activity EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CFTR protein CTD PMID:15496164 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977
JBrowse link
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity EXP 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein mutant form CTD PMID:21778469 NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827
JBrowse link
7,9-dihydro-1H-purine-2,6,8(3H)-trione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC2A9 solute carrier family 2 member 9 increases transport EXP SLC2A9 protein results in increased transport of Uric Acid CTD PMID:18989453 NCBI chr 3:69,394,304...69,588,462
Ensembl chr 3:69,394,152...69,595,802
JBrowse link
8-(4-chlorophenylthio)-cAMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator multiple interactions EXP [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein CTD PMID:15161604 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977
JBrowse link
acetylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766
JBrowse link
G KCNJ6 potassium inwardly rectifying channel subfamily J member 6 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions EXP Acetylcholine results in increased phosphorylation of and results in increased activity of MAPK14 protein CTD PMID:9688607 NCBI chr12:5,145,647...5,221,558
Ensembl chr12:5,146,037...5,220,603
JBrowse link
acyclovir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AVP arginine vasopressin decreases activity EXP Acyclovir results in decreased activity of AVP protein CTD PMID:2724137 NCBI chr24:18,183,057...18,184,827
Ensembl chr24:18,183,057...18,184,883
JBrowse link
amiodarone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC8A1 solute carrier family 8 member A1 decreases activity EXP Amiodarone results in decreased activity of SLC8A1 protein CTD PMID:15288574 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700
JBrowse link
amlodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin increases expression EXP Amlodipine results in increased expression of REN protein CTD PMID:10218729 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
amosulalol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 multiple interactions EXP amosulalol binds to and results in decreased activity of ADRB1 protein CTD PMID:6129981 NCBI chr28:24,908,224...24,909,684
Ensembl chr28:24,908,224...24,909,684
JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP amosulalol binds to and results in decreased activity of ADRB2 protein CTD PMID:6129981 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298
JBrowse link
anthra[1,9-cd]pyrazol-6(2H)-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions EXP pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]] CTD PMID:23816505 NCBI chr 5:50,966,698...50,968,939 JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
JBrowse link
G SP1 Sp1 transcription factor multiple interactions EXP pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein] CTD PMID:23816505 NCBI chr27:1,802,587...1,861,187
Ensembl chr27:1,805,184...1,847,226
JBrowse link
antipyrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Antipyrine results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
arsane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP Arsenic results in increased phosphorylation of MAPK1 protein CTD PMID:29306782 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP Arsenic results in increased phosphorylation of MAPK3 protein CTD PMID:29306782 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
JBrowse link
arsenous acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:23236503 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:23236503 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
JBrowse link
G SLC9A1 solute carrier family 9 member A1 increases expression EXP Arsenic Trioxide results in increased expression of SLC9A1 protein CTD PMID:23236503 NCBI chr 2:73,054,742...73,103,364
Ensembl chr 2:73,054,742...73,103,364
JBrowse link
astemizole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions EXP Astemizole binds to and results in decreased activity of KCNH2 protein CTD PMID:12388285 NCBI chr16:15,009,031...15,041,786
Ensembl chr16:15,009,031...15,041,504
JBrowse link
atenolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin multiple interactions EXP Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] CTD PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
JBrowse link
Azaspiracid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH1 cadherin 1 decreases uptake EXP azaspiracid results in decreased uptake of CDH1 protein modified form CTD PMID:20547569 NCBI chr 5:80,757,508...80,834,878
Ensembl chr 5:80,757,508...80,834,878
JBrowse link
benazepril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DES desmin decreases expression EXP benazepril results in decreased expression of DES mRNA CTD PMID:20137276 NCBI chr37:25,933,525...25,939,910
Ensembl chr37:25,933,455...25,940,985
JBrowse link
blebbistatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases localization EXP blebbistatin results in decreased localization of ABCB11 protein CTD PMID:15826951 NCBI chr36:13,742,895...13,835,312
Ensembl chr36:13,746,964...13,834,974
JBrowse link
butyrylthiocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase increases hydrolysis EXP BCHE protein results in increased hydrolysis of Butyrylthiocholine CTD PMID:22407886 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
JBrowse link
capsaicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR1B 5-hydroxytryptamine receptor 1B multiple interactions EXP HTR1B protein promotes the reaction [donitriptan results in decreased susceptibility to Capsaicin] CTD PMID:16880765 NCBI chr12:38,659,088...38,659,546 JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions
increases activity
EXP JYL 1421 inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein] CTD PMID:17392452 NCBI chr 9:47,404,987...47,443,871
Ensembl chr 9:47,404,972...47,431,926
JBrowse link
carmustine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MGMT O-6-methylguanine-DNA methyltransferase decreases response to substance
multiple interactions
EXP MGMT protein mutant form results in decreased susceptibility to Carmustine; MGMT protein results in decreased susceptibility to Carmustine
MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]
CTD PMID:14617759, PMID:15053863 NCBI chr28:38,204,611...38,427,482
Ensembl chr28:38,204,610...38,427,380
JBrowse link
carprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP carprofen results in decreased expression of PTGS2 mRNA CTD PMID:15198222 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
carvedilol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 decreases activity EXP Carvedilol results in decreased activity of CASP3 protein CTD PMID:12875697 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
JBrowse link
G FAS Fas cell surface death receptor decreases expression EXP Carvedilol results in decreased expression of FAS CTD PMID:12875697 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321
JBrowse link
G FASLG Fas ligand decreases expression EXP Carvedilol results in decreased expression of FASLG CTD PMID:12875697 NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224
JBrowse link
G NT5E 5'-nucleotidase ecto increases activity EXP Carvedilol results in increased activity of NT5E protein CTD PMID:15148268 NCBI chr12:45,491,028...45,520,019
Ensembl chr12:45,491,733...45,518,405
JBrowse link
G RYR2 ryanodine receptor 2 multiple interactions EXP Carvedilol results in decreased oxidation of and results in increased stability of RYR2 protein CTD PMID:17448375 NCBI chr 4:2,371,868...2,908,132
Ensembl chr 4:2,373,114...2,907,875
JBrowse link
cilazapril monohydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen decreases expression EXP Cilazapril results in decreased expression of AGT protein CTD PMID:2419701 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
JBrowse link
G REN renin increases activity EXP Cilazapril results in increased activity of REN protein CTD PMID:2419701 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
cilostazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression EXP Cilostazol results in decreased expression of MYC mRNA CTD PMID:19545562 NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309
JBrowse link
cisapride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions EXP Cisapride binds to and results in decreased activity of KCNH2 protein CTD PMID:12388285 NCBI chr16:15,009,031...15,041,786
Ensembl chr16:15,009,031...15,041,504
JBrowse link
clonidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A multiple interactions
increases response to substance
EXP Clonidine binds to and results in increased activity of ADRA2A protein
ADRA2A protein results in increased susceptibility to Clonidine
CTD PMID:16814767 NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684
JBrowse link
G ADRA2C adrenoceptor alpha 2C increases response to substance EXP ADRA2C protein results in increased susceptibility to Clonidine CTD PMID:16814767 NCBI chr 3:60,608,632...60,648,112
Ensembl chr 3:60,646,132...60,647,722
JBrowse link
G NISCH nischarin multiple interactions
affects binding
EXP Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein] CTD PMID:24120658 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions
increases activity
EXP [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664
JBrowse link
G REN renin multiple interactions
decreases activity
EXP Clonidine results in decreased secretion of and results in decreased activity of REN protein
Clonidine results in decreased activity of REN protein
CTD PMID:6248808, PMID:6991409 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
clonidine (amino form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A multiple interactions
increases response to substance
EXP Clonidine binds to and results in increased activity of ADRA2A protein
ADRA2A protein results in increased susceptibility to Clonidine
CTD PMID:16814767 NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684
JBrowse link
G ADRA2C adrenoceptor alpha 2C increases response to substance EXP ADRA2C protein results in increased susceptibility to Clonidine CTD PMID:16814767 NCBI chr 3:60,608,632...60,648,112
Ensembl chr 3:60,646,132...60,647,722
JBrowse link
G NISCH nischarin affects binding
multiple interactions
EXP Clonidine binds to NISCH protein
Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein]
CTD PMID:24120658 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma increases activity
multiple interactions
EXP Clonidine results in increased activity of PIK3CG protein
[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein]
CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664
JBrowse link
G REN renin multiple interactions
decreases activity
EXP Clonidine results in decreased secretion of and results in decreased activity of REN protein
Clonidine results in decreased activity of REN protein
CTD PMID:6248808, PMID:6991409 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
clonidine (imino form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A multiple interactions
increases response to substance
EXP Clonidine binds to and results in increased activity of ADRA2A protein
ADRA2A protein results in increased susceptibility to Clonidine
CTD PMID:16814767 NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684
JBrowse link
G ADRA2C adrenoceptor alpha 2C increases response to substance EXP ADRA2C protein results in increased susceptibility to Clonidine CTD PMID:16814767 NCBI chr 3:60,608,632...60,648,112
Ensembl chr 3:60,646,132...60,647,722
JBrowse link
G NISCH nischarin affects binding
multiple interactions
EXP Clonidine binds to NISCH protein
Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein]
CTD PMID:24120658 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions
increases activity
EXP [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664
JBrowse link
G REN renin multiple interactions
decreases activity
EXP Clonidine results in decreased secretion of and results in decreased activity of REN protein
Clonidine results in decreased activity of REN protein
CTD PMID:6248808, PMID:6991409 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
clotrimazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Clotrimazole results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 affects binding
increases activity
EXP Clotrimazole binds to NR1I3 protein
Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein mutant form
CTD PMID:21778469, PMID:27732639 NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827
JBrowse link
corticotropin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin increases abundance EXP INS protein results in increased abundance of Adrenocorticotropic Hormone CTD PMID:1646414 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
JBrowse link
cyclophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6 cytochrome P450 2B11 increases hydroxylation EXP CYP2B6 protein results in increased hydroxylation of Cyclophosphamide CTD PMID:16546968 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293
JBrowse link
cytidine 5'-monophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions EXP [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate CTD PMID:2579070 NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653
JBrowse link
desferrioxamine B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions EXP Deferoxamine inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin] CTD PMID:8021468 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
JBrowse link
desipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2D15 cytochrome P450 2D affects metabolic processing EXP CYP2D15 affects the metabolism of Desipramine CTD PMID:7786018 NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298
JBrowse link
dexmedetomidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NISCH nischarin affects activity EXP Dexmedetomidine affects the activity of NISCH CTD PMID:7486159 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636
JBrowse link
dextromethorphan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6 cytochrome P450 2B11 increases metabolic processing EXP CYP2B6 protein results in increased metabolism of Dextromethorphan CTD PMID:12637241 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293
JBrowse link
G CYP2D15 cytochrome P450 2D affects metabolic processing EXP CYP2D15 affects the metabolism of Dextromethorphan CTD PMID:7786018 NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298
JBrowse link
diarsenic trioxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:23236503 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:23236503 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
JBrowse link
G SLC9A1 solute carrier family 9 member A1 increases expression EXP Arsenic Trioxide results in increased expression of SLC9A1 protein CTD PMID:23236503 NCBI chr 2:73,054,742...73,103,364
Ensembl chr 2:73,054,742...73,103,364
JBrowse link
diazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A12 cytochrome P-450 3A12 multiple interactions
increases hydroxylation
EXP Ketoconazole inhibits the reaction [CYP3A12 protein results in increased hydroxylation of Diazepam] CTD PMID:15677349
dichlorvos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase decreases activity EXP Dichlorvos results in decreased activity of ACHE protein CTD PMID:89824, PMID:3627083 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
JBrowse link
G BCHE butyrylcholinesterase decreases activity EXP Dichlorvos results in decreased activity of BCHE protein CTD PMID:3627083, PMID:4631366 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
JBrowse link
diclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C41 cytochrome P450 2C41 affects metabolic processing EXP CYP2C9 protein affects the metabolism of Diclofenac CTD PMID:15801540
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Diclofenac results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
diethyldithiocarbamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions EXP Ditiocarb inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene] CTD PMID:8592870 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754
JBrowse link
dihexadecanoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 multiple interactions
increases activity
EXP dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]
dipalmitoylphosphatidic acid results in increased activity of PLCG1 protein
CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714
JBrowse link
diisopropyl fluorophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase decreases activity EXP Isoflurophate results in decreased activity of BCHE protein CTD PMID:4631366 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
JBrowse link
dimyristoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP dimyristoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714
JBrowse link
dioleoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP dioleoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714
JBrowse link
DPDPE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B3 solute carrier organic anion transporter family member 1B3 increases transport EXP SLCO1B3 protein results in increased transport of Enkephalin, D-Penicillamine (2,5)- CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989
JBrowse link
edaravone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SELP selectin P decreases expression EXP Edaravone results in decreased expression of SELP protein CTD PMID:16041266 NCBI chr 7:28,956,428...28,997,266
Ensembl chr 7:28,958,486...28,996,313
JBrowse link
emodepside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects response to substance EXP ABCB1 protein affects the susceptibility to emodepside CTD PMID:25660379 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
enalapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of ATP2A2 protein CTD PMID:18820026 NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388
JBrowse link
G EGR1 early growth response 1 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of EGR1 protein CTD PMID:18820026 NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575
JBrowse link
G GATA4 GATA binding protein 4 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein CTD PMID:18820026 NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989
JBrowse link
G KCND3 potassium voltage-gated channel subfamily D member 3 decreases expression EXP Enalapril results in decreased expression of KCND3 mRNA CTD PMID:19732978 NCBI chr17:63,470,829...63,668,354
Ensembl chr17:63,470,415...63,668,035
JBrowse link
G NAB1 NGFI-A binding protein 1 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of NAB1 protein CTD PMID:18820026 NCBI chr37:1,207,619...1,243,546
Ensembl chr37:1,207,638...1,241,610
JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
increases expression
EXP FR 173657 inhibits the reaction [Enalapril results in increased expression of NOS3 mRNA] CTD PMID:12019275 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
JBrowse link
G NPPA natriuretic peptide A decreases expression
multiple interactions
EXP Enalapril results in decreased expression of NPPA protein
FR 173657 inhibits the reaction [Enalapril results in decreased expression of NPPA protein]
CTD PMID:12019275 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
JBrowse link
G REN renin increases activity
multiple interactions
EXP Enalapril results in increased activity of REN protein
[Enalapril co-treated with FR 173657] results in increased activity of REN protein
CTD PMID:12019275 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
G SLC8A1 solute carrier family 8 member A1 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein CTD PMID:18820026 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700
JBrowse link
felodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Felodipine results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
JBrowse link
fenfluramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases activity EXP Fenfluramine results in increased activity of EDN1 protein CTD PMID:9918753 NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383
JBrowse link
flufenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 decreases activity EXP Flufenamic Acid results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
fomepizole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions EXP Fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene] CTD PMID:8592870 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754
JBrowse link
ganglioside GM1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNAQ G protein subunit alpha q multiple interactions EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein] CTD PMID:21671308 NCBI chr 1:80,733,530...80,928,065
Ensembl chr 1:80,715,366...80,928,065
JBrowse link
G HEXB hexosaminidase subunit beta multiple interactions EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; G(M1) Ganglioside inhibits the reaction [Melitten results in increased secretion of HEXB protein]; G(M1) Ganglioside inhibits the reaction [Wasp Venoms results in increased secretion of HEXB protein] CTD PMID:21334356, PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
JBrowse link
glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] CTD PMID:23816505 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:23816505 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
JBrowse link
glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator decreases activity EXP Glyburide results in decreased activity of CFTR protein CTD PMID:15496164 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977
JBrowse link
idazoxan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NISCH nischarin multiple interactions EXP Idazoxan binds to and results in decreased activity of NISCH protein CTD PMID:8732285 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636
JBrowse link
imidazoles term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I3 nuclear receptor subfamily 1 group I member 3 decreases activity
multiple interactions
EXP Imidazoles results in decreased activity of NR1I3 protein alternative form
artemisinine inhibits the reaction [Imidazoles results in decreased activity of NR1I3 protein alternative form]; Imidazoles inhibits the reaction [artemisinine results in increased activity of NR1I3 protein mutant form]
CTD PMID:21778469 NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827
JBrowse link
indometacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions EXP Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Indomethacin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
iprodione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP [iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866
JBrowse link
isatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 dehydrogenase/reductase 4 increases reduction EXP DHRS4 protein results in increased reduction of Isatin CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
isoprenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin multiple interactions
increases activity
EXP Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; Pindolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; xibenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] CTD PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
ketoconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases expression
multiple interactions
decreases activity
EXP Ketoconazole results in decreased expression of ABCB1 mRNA
[Ketoconazole results in decreased activity of ABCB1 protein] which results in decreased transport of Technetium Tc 99m Sestamibi
CTD PMID:19754906, PMID:22620706 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G CYP3A12 cytochrome P-450 3A12 multiple interactions
decreases activity
EXP Ketoconazole inhibits the reaction [CYP3A12 protein results in increased hydroxylation of Diazepam]
Ketoconazole results in decreased activity of CYP3A12 protein
CTD PMID:15677349
loperamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects response to substance
increases export
EXP ABCB1 protein affects the susceptibility to Loperamide
ABCB1 protein results in increased export of Loperamide
CTD PMID:25660379, PMID:28093773 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
Loratadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity EXP Loratadine results in increased activity of CASP3 protein CTD PMID:20570632 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
JBrowse link
losartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin increases expression EXP Losartan results in increased expression of REN protein CTD PMID:10483973 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
losartan carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin increases expression EXP losartan carboxylic acid results in increased expression of REN protein CTD PMID:10483973 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
LY294002 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of PIK3CG protein] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
JBrowse link
G PRKCZ protein kinase C zeta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664
JBrowse link
marbofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP8 caspase 8 multiple interactions
increases expression
EXP TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of CASP8 mRNA] CTD PMID:31005593 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822
JBrowse link
G FADD Fas associated via death domain increases expression EXP marbofloxacin results in increased expression of FADD mRNA CTD PMID:31005593 NCBI chr18:48,087,447...48,094,497 JBrowse link
G TNF tumor necrosis factor increases expression EXP marbofloxacin results in increased expression of TNF mRNA; marbofloxacin results in increased expression of TNF protein CTD PMID:31005593 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A multiple interactions
increases expression
EXP TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of CASP8 mRNA]; TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of TRADD mRNA]
marbofloxacin results in increased expression of TNFRSF1A mRNA; marbofloxacin results in increased expression of TNFRSF1A protein
CTD PMID:31005593 NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282
JBrowse link
G TRADD TNFRSF1A associated via death domain multiple interactions
increases expression
EXP TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of TRADD mRNA] CTD PMID:31005593 NCBI chr 5:82,200,430...82,211,430
Ensembl chr 5:82,206,111...82,210,963
JBrowse link
mastoparan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNAQ G protein subunit alpha q multiple interactions EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]; ganglioside, GD1a inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]; mastoparan results in increased activity of and affects the localization of GNAQ protein CTD PMID:21671308 NCBI chr 1:80,733,530...80,928,065
Ensembl chr 1:80,715,366...80,928,065
JBrowse link
G HEXB hexosaminidase subunit beta multiple interactions
increases secretion
EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; ganglioside, GD1a inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein]; methyl-beta-cyclodextrin promotes the reaction [mastoparan results in increased secretion of HEXB protein]; Pertussis Toxin inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; Quinacrine promotes the reaction [mastoparan results in increased secretion of HEXB protein]; YM-254890 inhibits the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
JBrowse link
melittin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions
increases secretion
EXP G(M1) Ganglioside inhibits the reaction [Melitten results in increased secretion of HEXB protein]; sialogangliosides inhibits the reaction [Melitten results in increased secretion of HEXB protein]; trisialoganglioside GT1 inhibits the reaction [Melitten results in increased secretion of HEXB protein] CTD PMID:21334356 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
JBrowse link
mephenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6 cytochrome P450 2B11 increases hydroxylation EXP CYP2B6 protein results in increased hydroxylation of Mephenytoin CTD PMID:12637241 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293
JBrowse link
metoprolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of ATP2A2 protein CTD PMID:18820026 NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388
JBrowse link
G CYP2D15 cytochrome P450 2D affects metabolic processing EXP CYP2D15 affects the metabolism of Metoprolol CTD PMID:7786018 NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298
JBrowse link
G EGR1 early growth response 1 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of EGR1 protein CTD PMID:18820026 NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575
JBrowse link
G GATA4 GATA binding protein 4 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein CTD PMID:18820026 NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989
JBrowse link
G NAB1 NGFI-A binding protein 1 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of NAB1 protein CTD PMID:18820026 NCBI chr37:1,207,619...1,243,546
Ensembl chr37:1,207,638...1,241,610
JBrowse link
G SLC8A1 solute carrier family 8 member A1 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein CTD PMID:18820026 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700
JBrowse link
mexiletine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases response to substance EXP ABCB1 mutant form results in increased susceptibility to Mexiletine CTD PMID:16594604 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
midazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A26 cytochrome P450 3A26 affects metabolic processing EXP CYP3A5 protein affects the metabolism of Midazolam CTD PMID:15801540 NCBI chr 6:9,777,663...9,815,345
Ensembl chr 6:9,777,659...9,869,352
JBrowse link
G CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 affects metabolic processing EXP CYP3A4 protein affects the metabolism of Midazolam CTD PMID:15801540 NCBI chr 6:9,836,685...9,869,520
Ensembl chr 6:9,777,659...9,869,352
JBrowse link
ML-7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin] CTD PMID:20510202 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G MYLK myosin light chain kinase multiple interactions EXP [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin] CTD PMID:20510202 NCBI chr33:26,663,991...26,867,370
Ensembl chr33:26,664,800...26,843,181
JBrowse link
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL6 interleukin 6 multiple interactions
decreases expression
EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of IL6 protein
CTD PMID:24105867 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519
JBrowse link
G PRKACB protein kinase cAMP-activated catalytic subunit beta multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein] CTD PMID:24105867 NCBI chr 6:63,615,445...63,729,386
Ensembl chr 6:63,618,323...63,730,146
JBrowse link
N-acetyl-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] CTD PMID:23816505 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:23816505 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
JBrowse link
N-nitrosodimethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 decreases expression EXP Dimethylnitrosamine results in decreased expression of GJA1 protein CTD PMID:15736408 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936
JBrowse link
Naftopidil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA1D adrenoceptor alpha 1D multiple interactions EXP naftopidil binds to and results in decreased activity of ADRA1D protein; naftopidil inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein] CTD PMID:19371927 NCBI chr24:17,213,615...17,221,725
Ensembl chr24:17,213,643...17,214,761
JBrowse link
Nalmefene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POMC proopiomelanocortin increases expression EXP nalmefene results in increased expression of POMC protein alternative form CTD PMID:3026683 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
JBrowse link
naloxone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POMC proopiomelanocortin increases expression EXP Naloxone results in increased expression of POMC protein CTD PMID:8277081 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
JBrowse link
nefiracetam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 affects expression
increases expression
EXP nefiracetam affects the expression of PTGS2 mRNA
nefiracetam results in increased expression of PTGS2 protein
CTD PMID:16105799 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
nicotinamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARG peroxisome proliferator activated receptor gamma increases expression
multiple interactions
EXP Niacinamide results in increased expression of PPARG protein
Resveratrol inhibits the reaction [Niacinamide results in increased expression of PPARG protein]
CTD PMID:22539994 NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981
JBrowse link
G RUNX2 RUNX family transcription factor 2 decreases expression
increases acetylation
multiple interactions
EXP Niacinamide results in decreased expression of RUNX2 protein
Niacinamide results in increased acetylation of RUNX2 protein
Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide results in increased acetylation of RUNX2 protein]
CTD PMID:22539994 NCBI chr12:13,723,535...13,842,565
Ensembl chr12:13,628,539...13,840,785
JBrowse link
G SIRT1 sirtuin 1 decreases expression
multiple interactions
EXP Niacinamide results in decreased expression of SIRT1 protein
Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of SIRT1 protein]
CTD PMID:22539994 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279
JBrowse link
nimesulide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL1B interleukin 1 beta decreases expression EXP nimesulide results in decreased expression of IL1B mRNA CTD PMID:19638440 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458
JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP nimesulide results in decreased expression of PTGS2 mRNA CTD PMID:15198222 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
nitric oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNG1 kininogen 1 increases activity EXP Nitric Oxide deficiency results in increased activity of KNG1 protein modified form CTD PMID:10805402 NCBI chr34:19,288,629...19,318,096
Ensembl chr34:19,287,109...19,318,081
JBrowse link
G WT1 WT1 transcription factor multiple interactions EXP [Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA CTD PMID:21443142 NCBI chr18:35,099,660...35,148,767
Ensembl chr18:35,103,934...35,148,000
JBrowse link
nitrites term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNG1 kininogen 1 increases chemical synthesis EXP KNG1 protein modified form results in increased chemical synthesis of Nitrites CTD PMID:17644579 NCBI chr34:19,288,629...19,318,096
Ensembl chr34:19,287,109...19,318,081
JBrowse link
nitroglycerin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin decreases activity EXP Nitroglycerin results in decreased activity of REN protein CTD PMID:8640982 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
NS-398 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of PTGS2 mRNA; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of PTGS2 protein CTD PMID:12857884, PMID:15198222 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases localization EXP N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased localization of RELA protein CTD PMID:12857884 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875
JBrowse link
ofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAPN1 calpain 1 increases expression EXP Ofloxacin results in increased expression of CAPN1 mRNA CTD PMID:24582689 NCBI chr18:51,983,266...52,010,831
Ensembl chr18:51,983,824...52,010,757
JBrowse link
G CASP12 caspase 12 increases expression EXP Ofloxacin results in increased expression of CASP12 mRNA; Ofloxacin results in increased expression of CASP12 protein CTD PMID:24582689 NCBI chr 5:27,162,840...27,176,964
Ensembl chr 5:27,161,700...27,177,683
JBrowse link
G CASP8 caspase 8 multiple interactions
increases expression
EXP TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA] CTD PMID:24582689 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822
JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP Ofloxacin results in increased expression of DDIT3 mRNA CTD PMID:24582689 NCBI chr10:1,606,693...1,612,410
Ensembl chr10:1,606,693...1,611,303
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Ofloxacin results in increased expression of HSPA5 mRNA CTD PMID:24582689 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257
JBrowse link
G TNF tumor necrosis factor increases expression EXP Ofloxacin results in increased expression of TNF mRNA; Ofloxacin results in increased expression of TNF protein CTD PMID:24582689 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425
JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A multiple interactions
increases expression
EXP TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA]; TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA]
Ofloxacin results in increased expression of TNFRSF1A mRNA; Ofloxacin results in increased expression of TNFRSF1A protein
CTD PMID:24582689 NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282
JBrowse link
G TRADD TNFRSF1A associated via death domain multiple interactions
increases expression
EXP TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA] CTD PMID:24582689 NCBI chr 5:82,200,430...82,211,430
Ensembl chr 5:82,206,111...82,210,963
JBrowse link
omeprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Omeprazole results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
JBrowse link
paracetamol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Acetaminophen results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
G UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 increases glucuronidation EXP UGT1A6 protein results in increased glucuronidation of Acetaminophen CTD PMID:11903872 NCBI chr25:45,081,655...45,161,584
Ensembl chr25:45,032,130...45,160,941
JBrowse link
paraoxon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase decreases activity EXP Paraoxon results in decreased activity of BCHE protein CTD PMID:4631366 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
JBrowse link
pentobarbital term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin increases activity EXP Pentobarbital results in increased activity of REN protein CTD PMID:6348358 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
phenacetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 affects metabolic processing EXP CYP1A2 protein affects the metabolism of Phenacetin CTD PMID:15801540 NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135
JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Phenacetin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
phenobarbital term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAA1 acetyl-CoA acyltransferase 1 decreases expression EXP Phenobarbital results in decreased expression of ACAA1 mRNA CTD PMID:19952500 NCBI chr23:7,889,481...7,901,324
Ensembl chr23:7,889,500...7,901,229
JBrowse link
G ACAA2 acetyl-CoA acyltransferase 2 decreases expression EXP Phenobarbital results in decreased expression of ACAA2 mRNA CTD PMID:19952500 NCBI chr 7:79,028,636...79,057,720 JBrowse link
G ACOX2 acyl-CoA oxidase 2 decreases expression EXP Phenobarbital results in decreased expression of ACOX2 mRNA CTD PMID:19952500 NCBI chr20:32,110,788...32,141,751
Ensembl chr20:32,113,217...32,141,734
JBrowse link
G AHCY adenosylhomocysteinase decreases expression EXP Phenobarbital results in decreased expression of AHCY protein CTD PMID:19952500 NCBI chr24:23,410,553...23,423,494
Ensembl chr24:23,411,140...23,419,767
JBrowse link
G ASL argininosuccinate lyase decreases expression EXP Phenobarbital results in decreased expression of ASL protein CTD PMID:19952500 NCBI chr 6:768,522...779,144
Ensembl chr 6:730,358...779,424
JBrowse link
G ASS1 argininosuccinate synthase 1 decreases expression EXP Phenobarbital results in decreased expression of ASS1 protein CTD PMID:19952500 NCBI chr 9:53,425,228...53,478,007
Ensembl chr 9:53,425,448...53,477,904
JBrowse link
G BHMT betaine--homocysteine S-methyltransferase decreases expression EXP Phenobarbital results in decreased expression of BHMT protein CTD PMID:19952500 NCBI chr 3:27,732,381...27,752,168
Ensembl chr 3:27,734,108...27,752,046
JBrowse link
G CA3 carbonic anhydrase 3 decreases expression EXP Phenobarbital results in decreased expression of CA3 protein CTD PMID:19952500 NCBI chr29:31,935,192...31,945,585
Ensembl chr29:31,935,172...31,980,579
JBrowse link
G CPT1A carnitine palmitoyltransferase 1A decreases expression EXP Phenobarbital results in decreased expression of CPT1A mRNA CTD PMID:19952500 NCBI chr18:49,136,691...49,190,117
Ensembl chr18:49,136,691...49,190,117
JBrowse link
G CRYZ crystallin zeta increases expression EXP Phenobarbital results in increased expression of CRYZ protein CTD PMID:19952500 NCBI chr 6:71,656,162...71,693,020
Ensembl chr 6:71,656,188...71,675,692
JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases expression EXP Phenobarbital results in decreased expression of CYP1A2 mRNA CTD PMID:19952500 NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135
JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A polypeptide 13 decreases expression EXP Phenobarbital results in decreased expression of CYP2A13 mRNA CTD PMID:19952500 NCBI chr 1:112,932,246...112,938,248
Ensembl chr 1:112,931,985...112,938,350
JBrowse link
G CYP2B6 cytochrome P450 2B11 increases expression EXP Phenobarbital results in increased expression of CYP2B6 protein CTD PMID:19952500 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293
JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases expression EXP Phenobarbital results in decreased expression of CYP2E1 mRNA CTD PMID:19952500 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754
JBrowse link
G CYP3A12 cytochrome P-450 3A12 increases expression EXP Phenobarbital results in increased expression of CYP3A12 protein CTD PMID:19952500
G CYP3A26 cytochrome P450 3A26 increases expression EXP Phenobarbital results in increased expression of CYP3A26 mRNA CTD PMID:19952500 NCBI chr 6:9,777,663...9,815,345
Ensembl chr 6:9,777,659...9,869,352
JBrowse link
G CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 increases expression EXP Phenobarbital results in increased expression of CYP3A4 mRNA CTD PMID:19952500 NCBI chr 6:9,836,685...9,869,520
Ensembl chr 6:9,777,659...9,869,352
JBrowse link
G CYP4A11 cytochrome P450, family 4, subfamily A, polypeptide 11 decreases expression EXP Phenobarbital results in decreased expression of CYP4A11 mRNA CTD PMID:19952500 NCBI chr15:13,663,337...13,676,350
Ensembl chr15:13,604,130...13,676,344
JBrowse link
G EHHADH enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase decreases expression EXP Phenobarbital results in decreased expression of EHHADH mRNA CTD PMID:19952500 NCBI chr34:18,021,047...18,080,993
Ensembl chr34:18,022,353...18,080,903
JBrowse link
G FTCD formimidoyltransferase cyclodeaminase increases expression EXP Phenobarbital results in increased expression of FTCD protein CTD PMID:19952500 NCBI chr31:39,451,557...39,464,249
Ensembl chr31:39,275,159...39,464,715
JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 decreases expression EXP Phenobarbital results in decreased expression of GOT1 protein CTD PMID:19952500 NCBI chr28:12,352,658...12,377,960
Ensembl chr28:12,352,659...12,414,579
JBrowse link
G GSTA4 glutathione S-transferase alpha 4 decreases expression EXP Phenobarbital results in decreased expression of GSTA4 mRNA CTD PMID:19952500 NCBI chr12:20,426,724...20,443,200
Ensembl chr12:20,426,726...20,443,200
JBrowse link
G GSTO1 glutathione S-transferase omega 1 increases expression EXP Phenobarbital results in increased expression of GSTO1 mRNA CTD PMID:19952500 NCBI chr28:16,569,421...16,579,239
Ensembl chr28:16,569,066...16,619,880
JBrowse link
G HADH hydroxyacyl-CoA dehydrogenase decreases expression EXP Phenobarbital results in decreased expression of HADH mRNA CTD PMID:19952500 NCBI chr32:28,460,445...28,506,141
Ensembl chr32:28,460,193...28,531,280
JBrowse link
G HPD 4-hydroxyphenylpyruvate dioxygenase decreases expression EXP Phenobarbital results in decreased expression of HPD protein CTD PMID:19952500 NCBI chr26:7,430,891...7,440,643
Ensembl chr26:7,430,933...7,440,611
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Phenobarbital results in increased expression of HSPA5 protein CTD PMID:19952500 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257
JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 decreases expression EXP Phenobarbital results in decreased expression of IDH1 protein CTD PMID:19952500 NCBI chr37:16,512,027...16,531,269
Ensembl chr37:16,512,770...16,531,219
JBrowse link
G LOC100855679 serine--pyruvate aminotransferase, mitochondrial decreases expression EXP Phenobarbital results in decreased expression of AGXT protein CTD PMID:19952500 NCBI chr25:50,968,291...50,976,089 JBrowse link
G LOC474938 glutathione S-transferase A2 increases expression EXP Phenobarbital results in increased expression of GSTA3 protein CTD PMID:19952500 NCBI chr12:20,349,133...20,365,023 JBrowse link
G LOC477540 SEC14-like protein 3 decreases expression EXP Phenobarbital results in decreased expression of SEC14L3 protein CTD PMID:19952500 NCBI chr26:23,580,899...23,590,676
Ensembl chr26:23,580,901...23,590,622
JBrowse link
G LOC479912 glutathione S-transferase Mu 1 decreases expression EXP Phenobarbital results in decreased expression of GSTM1 mRNA; Phenobarbital results in decreased expression of GSTM5 mRNA CTD PMID:19952500 NCBI chr 6:42,201,697...42,207,886 JBrowse link
G LOC486353 SEC14-like protein 4 decreases expression EXP Phenobarbital results in decreased expression of SEC14L4 protein CTD PMID:19952500 NCBI chr26:23,598,434...23,611,727
Ensembl chr26:23,600,237...23,618,123
JBrowse link
G LOC609777 UDP-glucuronosyltransferase 2B31-like increases expression EXP Phenobarbital results in increased expression of UGT2B4 protein CTD PMID:19952500
G MGST1 microsomal glutathione S-transferase 1 increases expression EXP Phenobarbital results in increased expression of MGST1 mRNA CTD PMID:19952500 NCBI chr27:30,370,588...30,391,898
Ensembl chr27:30,370,594...30,391,778
JBrowse link
G MGST2 microsomal glutathione S-transferase 2 increases expression EXP Phenobarbital results in increased expression of MGST2 mRNA CTD PMID:19952500 NCBI chr19:3,067,062...3,070,579 JBrowse link
G MGST3 microsomal glutathione S-transferase 3 decreases expression EXP Phenobarbital results in decreased expression of MGST3 mRNA CTD PMID:19952500 NCBI chr38:17,670,329...17,691,822
Ensembl chr38:17,668,752...17,718,704
JBrowse link
G PAH phenylalanine hydroxylase decreases expression EXP Phenobarbital results in decreased expression of PAH protein CTD PMID:19952500 NCBI chr15:41,590,253...41,670,156
Ensembl chr15:41,592,876...41,670,837
JBrowse link
G PDIA3 protein disulfide isomerase family A member 3 increases expression EXP Phenobarbital results in increased expression of PDIA3 protein CTD PMID:19952500 NCBI chr30:10,487,926...10,513,437
Ensembl chr30:10,487,921...10,513,397
JBrowse link
G PRDX6 peroxiredoxin 6 decreases expression EXP Phenobarbital results in decreased expression of PRDX6 protein CTD PMID:19952500 NCBI chr 7:25,663,238...25,675,855
Ensembl chr 7:25,663,579...25,675,754
JBrowse link
G SELENBP1 selenium binding protein 1 decreases expression EXP Phenobarbital results in decreased expression of SELENBP1 protein CTD PMID:19952500 NCBI chr17:60,410,727...60,418,770
Ensembl chr17:60,410,734...60,418,704
JBrowse link
G SOD1 superoxide dismutase 1 affects response to substance EXP SOD1 protein affects the susceptibility to Phenobarbital CTD PMID:6333936 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815
JBrowse link
G UGDH UDP-glucose 6-dehydrogenase increases expression EXP Phenobarbital results in increased expression of UGDH protein CTD PMID:19952500 NCBI chr 3:72,935,532...72,964,151
Ensembl chr 3:72,839,920...72,963,208
JBrowse link
G UROC1 urocanate hydratase 1 decreases expression EXP Phenobarbital results in decreased expression of UROC1 protein CTD PMID:19952500 NCBI chr20:676,624...717,109
Ensembl chr20:678,073...717,141
JBrowse link
phenylephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA1A adrenoceptor alpha 1A multiple interactions EXP Phenylephrine binds to and results in increased activity of ADRA1A protein; silodosin inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:19371927 NCBI chr25:30,690,959...30,801,484
Ensembl chr25:30,693,571...30,801,486
JBrowse link
G ADRA1D adrenoceptor alpha 1D multiple interactions EXP BMY 7378 inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein]; naftopidil inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein]; Phenylephrine binds to and results in increased activity of ADRA1D protein CTD PMID:19371927 NCBI chr24:17,213,615...17,221,725
Ensembl chr24:17,213,643...17,214,761
JBrowse link
G REN renin increases secretion EXP Phenylephrine results in increased secretion of REN protein CTD PMID:6347479 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
phosphatidylinositol 3-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; [Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
JBrowse link
phosphoryl trichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase decreases activity EXP phosphoryl chloride results in decreased activity of BCHE protein CTD PMID:12641435 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
JBrowse link
pindolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin multiple interactions EXP Pindolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] CTD PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
pitavastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NCF1 neutrophil cytosolic factor 1 decreases expression EXP pitavastatin results in decreased expression of NCF1 mRNA CTD PMID:15502390 NCBI chr 6:5,702,222...5,719,515
Ensembl chr 6:5,605,694...5,719,458
JBrowse link
G NOS3 nitric oxide synthase 3 increases activity
increases expression
EXP pitavastatin results in increased activity of NOS3 protein
pitavastatin results in increased expression of NOS3 mRNA
CTD PMID:15502390 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
JBrowse link
G NOX4 NADPH oxidase 4 decreases expression EXP pitavastatin results in decreased expression of NOX4 mRNA CTD PMID:15502390 NCBI chr21:10,615,153...10,782,927
Ensembl chr21:10,615,970...10,775,277
JBrowse link
prochloraz term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP [prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866
JBrowse link
propranolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB2 adrenoceptor beta 2 multiple interactions EXP [Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine CTD PMID:2884805 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298
JBrowse link
G NPPA natriuretic peptide A increases expression EXP Propranolol results in increased expression of NPPA protein CTD PMID:2566282 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
JBrowse link
G REN renin multiple interactions
decreases activity
EXP Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]
Propranolol results in decreased activity of REN protein
CTD PMID:2566282, PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
G VIP vasoactive intestinal peptide decreases expression EXP Propranolol results in decreased expression of VIP protein CTD PMID:2566282 NCBI chr 1:42,941,655...42,950,160
Ensembl chr 1:42,941,224...42,950,700
JBrowse link
pyridines term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DRD2 dopamine receptor D2 multiple interactions EXP Pyridines analog binds to and results in decreased activity of DRD2 protein CTD PMID:12593651 NCBI chr 5:19,732,842...19,795,241
Ensembl chr 5:19,732,836...19,795,241
JBrowse link
quinacrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions EXP Quinacrine promotes the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417
JBrowse link
ranolazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects expression
multiple interactions
EXP Ranolazine affects the expression of ATP2A2 protein
[Ranolazine co-treated with Enalapril] affects the expression of ATP2A2 protein; [Ranolazine co-treated with Metoprolol] affects the expression of ATP2A2 protein
CTD PMID:18820026 NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388
JBrowse link
G EGR1 early growth response 1 multiple interactions
affects expression
EXP [Ranolazine co-treated with Enalapril] affects the expression of EGR1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of EGR1 protein
Ranolazine affects the expression of EGR1 protein
CTD PMID:18820026 NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575
JBrowse link
G GATA4 GATA binding protein 4 affects expression
multiple interactions
EXP Ranolazine affects the expression of GATA4 protein
[Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein; [Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein
CTD PMID:18820026 NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989
JBrowse link
G NAB1 NGFI-A binding protein 1 affects expression
multiple interactions
EXP Ranolazine affects the expression of NAB1 protein
[Ranolazine co-treated with Enalapril] affects the expression of NAB1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of NAB1 protein
CTD PMID:18820026 NCBI chr37:1,207,619...1,243,546
Ensembl chr37:1,207,638...1,241,610
JBrowse link
G SLC8A1 solute carrier family 8 member A1 affects expression
multiple interactions
EXP Ranolazine affects the expression of SLC8A1 protein
[Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein
CTD PMID:18820026 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700
JBrowse link
rifampicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression EXP Rifampin results in increased expression of ABCB1 mRNA; Rifampin results in increased expression of ABCB1 protein CTD PMID:22620706 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Rifampin results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
JBrowse link
Rilmenidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin decreases activity EXP Rilmenidine results in decreased activity of REN protein CTD PMID:2866274 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
risperidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DRD2 dopamine receptor D2 multiple interactions EXP Risperidone binds to and results in decreased activity of DRD2 protein CTD PMID:16948927 NCBI chr 5:19,732,842...19,795,241
Ensembl chr 5:19,732,836...19,795,241
JBrowse link
ritonavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP allicin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] CTD PMID:15266218 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Ritonavir results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347
JBrowse link
salicylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
JBrowse link
saquinavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 protein affects the transport of Saquinavir CTD PMID:12702717 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740
JBrowse link
SDZ PSC 833 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin] CTD PMID:15492788, PMID:24975508 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
serotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen increases response to substance
multiple interactions
EXP AGT protein modified form results in increased susceptibility to Serotonin
Deferoxamine inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin]; Reactive Oxygen Species inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin]
CTD PMID:8021468 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
JBrowse link
G EDN1 endothelin 1 increases activity EXP Serotonin results in increased activity of EDN1 protein CTD PMID:9918753 NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383
JBrowse link
silodosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA1A adrenoceptor alpha 1A multiple interactions EXP silodosin binds to and results in decreased activity of ADRA1A protein; silodosin inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:19371927 NCBI chr25:30,690,959...30,801,484
Ensembl chr25:30,693,571...30,801,486
JBrowse link
sincalide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B3 solute carrier organic anion transporter family member 1B3 increases transport EXP SLCO1B3 protein results in increased transport of Sincalide CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989
JBrowse link
sodium arsenite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSR glutathione-disulfide reductase multiple interactions
decreases activity
EXP [monoisoamyl-2,3-dimercaptosuccinate co-treated with Succimer] inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] CTD PMID:18163546 NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752
JBrowse link
Soman term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions
decreases activity
EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
JBrowse link
G BCHE butyrylcholinesterase decreases activity EXP Soman results in decreased activity of BCHE protein CTD PMID:16915560 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
JBrowse link
SR 144528 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNR2 cannabinoid receptor 2 multiple interactions EXP SR 144528 binds to and results in decreased activity of CNR2 protein CTD PMID:21871882 NCBI chr 2:75,640,636...75,662,000
Ensembl chr 2:75,658,999...75,660,126
JBrowse link
succinylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase increases hydrolysis
multiple interactions
EXP BCHE protein results in increased hydrolysis of Succinylcholine
Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]
CTD PMID:4985882 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
JBrowse link
taurocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B3 solute carrier organic anion transporter family member 1B3 increases transport EXP SLCO1B3 protein results in increased transport of Taurocholic Acid CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989
JBrowse link
Temocaprilat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 protein affects the transport of temocaprilat CTD PMID:15507541 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740
JBrowse link
tolfenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP tolfenamic acid results in decreased expression of PTGS2 mRNA CTD PMID:15198222 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903
JBrowse link
triazoles term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity EXP Triazoles results in increased activity of NR1I3 protein alternative form CTD PMID:21778469 NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827
JBrowse link
troglitazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions EXP Troglitazone results in decreased activity of and results in decreased phosphorylation of RPS6KB1 protein CTD PMID:16825603 NCBI chr 9:34,387,084...34,590,603
Ensembl chr 9:34,387,091...34,425,292
JBrowse link
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
JBrowse link
tunicamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP Tunicamycin results in increased expression of HSP90B1 protein CTD PMID:17416481 NCBI chr15:42,456,793...42,474,122
Ensembl chr15:42,456,764...42,579,311
JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Tunicamycin results in increased expression of HSPA5 protein CTD PMID:17416481 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257
JBrowse link
urea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 increases expression EXP Urea results in increased expression of CLDN4 protein CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Urea results in increased expression of SOD2 protein CTD PMID:22718889 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
JBrowse link
UTP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions
increases activity
EXP [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid; [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059
JBrowse link
vasopressin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin multiple interactions EXP INS protein promotes the reaction [Sodium results in increased abundance of Vasopressins] CTD PMID:1324617 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
JBrowse link
verapamil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP [Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin CTD PMID:20510202 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
vincristine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases export
multiple interactions
affects response to substance
EXP ABCB1 protein results in increased export of Vincristine
valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine]
CTD PMID:24975508, PMID:28093773 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 decreases response to substance EXP ABCC1 protein results in decreased susceptibility to Vincristine CTD PMID:12516967 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331
JBrowse link
vorinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASQ1 calsequestrin 1 decreases expression EXP Vorinostat results in decreased expression of CASQ1 mRNA CTD PMID:27255383 NCBI chr38:22,012,060...22,020,430
Ensembl chr38:22,011,060...22,020,383
JBrowse link
G HSP70 heat shock protein 70 decreases expression EXP Vorinostat results in decreased expression of HSP70 mRNA CTD PMID:27255383 NCBI chr12:1,285,282...1,287,670 JBrowse link
G TNNI3K TNNI3 interacting kinase decreases expression EXP Vorinostat results in decreased expression of TNNI3K mRNA CTD PMID:27255383 NCBI chr 6:71,825,853...72,107,832
Ensembl chr 6:71,815,734...72,119,476
JBrowse link
VX nerve agent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions
decreases activity
EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
JBrowse link
G BCHE butyrylcholinesterase decreases activity EXP VX results in decreased activity of BCHE protein CTD PMID:16915560 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583
JBrowse link
WIN 55212-2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNR2 cannabinoid receptor 2 affects binding EXP Win 55212-2 binds to CNR2 protein CTD PMID:21871882 NCBI chr 2:75,640,636...75,662,000
Ensembl chr 2:75,658,999...75,660,126
JBrowse link
yohimbine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions EXP Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
JBrowse link
G PRKCZ protein kinase C zeta multiple interactions EXP Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664
JBrowse link
zileuton term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase decreases activity EXP zileuton results in decreased activity of ALOX5 protein CTD PMID:1618819 NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 225
    chemical entity 225
      molecular entity 225
        main group molecular entity 218
          p-block molecular entity 218
            pnictogen molecular entity 148
              antimony molecular entity + 0
              arsenic molecular entity + 4
              bismuth molecular entity + 0
              elemental pnictogen + 0
              nitrogen molecular entity + 146
              phosphorus molecular entity + 9
              pnictogen halide + 0
              pnictogen hydride + 73
              pnictogen oxoacid + 14
              pnictogen oxoanion + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 225
    subatomic particle 225
      composite particle 225
        hadron 225
          baryon 225
            nucleon 225
              atomic nucleus 225
                atom 225
                  main group element atom 218
                    p-block element atom 218
                      p-block molecular entity 218
                        pnictogen molecular entity 148
                          antimony molecular entity + 0
                          arsenic molecular entity + 4
                          bismuth molecular entity + 0
                          elemental pnictogen + 0
                          nitrogen molecular entity + 146
                          phosphorus molecular entity + 9
                          pnictogen halide + 0
                          pnictogen hydride + 73
                          pnictogen oxoacid + 14
                          pnictogen oxoanion + 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.