pnictogen - Ontology Report - Rat Genome Database

Submit Data | Help | Video Tutorials | News | Publications | Download | REST API | Citing RGD | Contact

Advanced Search (OLGA)

CHEBI ONTOLOGY - ANNOTATIONS

{{ watchLinkText }}

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	pnictogen	go back to main search page
Accession:	CHEBI:33300	browse the term
Definition:	Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth.
Synonyms:	exact_synonym:	pnictogens
	related_synonym:	group 15 elements; group V elements; nitrogenoideos; nitrogenoides; pnictogene; pnictogenes

show annotations for term's descendants Sort by:
Rat (19103) Mouse (20450) Human (23780) Chinchilla (0) Bonobo (0) Dog (421) Squirrel (0) Pig (557) Green Monkey (2) Naked Mole-rat (0) All
Genes (557)

(D-Ala(2)-mephe(4)-gly-ol(5))enkephalin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

opioid receptor mu 1

multiple interactions

Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased abundance of Catecholamines]]; Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein affects the reaction [Potassium results in increased transport of Barium]]; Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]; omega-Conotoxin GVIA inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]]

NCBI chr 1:12,634,125...12,702,295
Ensembl chr 1:12,528,672...12,702,443

(R)-carnitine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 5

increases uptake

SLC22A5 protein results in increased uptake of Carnitine

NCBI chr 2:134,660,741...134,847,575
Ensembl chr 2:134,660,808...134,686,219

(S)-colchicine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-microglobulin/bikunin precursor

decreases uptake

Colchicine results in decreased uptake of AMBP protein

NCBI chr 1:254,683,885...254,703,220
Ensembl chr 1:254,683,891...254,703,225

(S)-nicotine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenylate cyclase activating polypeptide 1

multiple interactions

Nicotine inhibits the reaction [[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1 protein]

NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294

G

ADCYAP receptor type I

decreases expression

Nicotine results in decreased expression of ADCYAP1R1 protein

NCBI chr18:41,915,180...41,972,327
Ensembl chr18:41,917,428...41,972,301

G

anti-Mullerian hormone

decreases expression
decreases secretion

Nicotine results in decreased expression of AMH mRNA
Nicotine results in decreased secretion of AMH protein

NCBI chr 2:76,415,564...76,418,315
Ensembl chr 2:76,414,427...76,418,312

G

BCL2 apoptosis regulator

decreases expression

Nicotine results in decreased expression of BCL2 mRNA

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

cholinergic receptor nicotinic alpha 2 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA2 protein]

NCBI chr14:11,193,732...11,204,334
Ensembl chr14:11,195,228...11,207,650

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA3 protein]

NCBI chr 7:47,361,710...47,382,743
Ensembl chr 7:47,361,899...47,384,303

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA7 protein]

NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,701...142,937,123

G

cholinergic receptor nicotinic alpha 9 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA9 protein]

NCBI chr 8:31,430,933...31,456,385
Ensembl chr 8:31,443,043...31,456,384

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNB2 protein]

NCBI chr 4:95,196,992...95,211,084
Ensembl chr 4:95,198,717...95,211,037

G

cytochrome P450 19A3

decreases expression

Nicotine results in decreased expression of CYP19A1 mRNA

NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899

G

follicle stimulating hormone receptor

decreases expression

Nicotine results in decreased expression of FSHR mRNA

NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683

G

inhibin subunit beta B

decreases expression
decreases secretion

Nicotine results in decreased expression of INHBB mRNA
Nicotine results in decreased secretion of INHBB protein

NCBI chr15:30,999,994...31,004,405
Ensembl chr15:30,999,520...31,004,405

G

integrin subunit beta 1

decreases expression

Nicotine results in decreased expression of ITGB1 mRNA

NCBI chr10:56,078,393...56,130,608
Ensembl chr10:56,078,396...56,173,326

G

laminin subunit beta 1

decreases expression

Nicotine results in decreased expression of LAMB1 mRNA

NCBI chr 9:107,670,120...107,747,242
Ensembl chr 9:107,671,152...107,772,269

G

mitogen-activated protein kinase 1

decreases phosphorylation
decreases expression

Nicotine results in decreased phosphorylation of MAPK1 protein
Nicotine results in decreased expression of MAPK1 mRNA

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 3

decreases expression
decreases phosphorylation

Nicotine results in decreased expression of MAPK3 mRNA
Nicotine results in decreased phosphorylation of MAPK3 protein

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

mitogen-activated protein kinase 8

decreases phosphorylation
decreases expression

Nicotine results in decreased phosphorylation of MAPK8 protein
Nicotine results in decreased expression of MAPK8 mRNA

NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874

G

matrix metallopeptidase 9

increases expression

Nicotine results in increased expression of MMP9 mRNA

NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788

G

occludin

decreases expression

Nicotine results in decreased expression of OCLN mRNA

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

ribonuclease P/MRP subunit p38

decreases expression

Nicotine results in decreased expression of RPP38 mRNA

NCBI chr10:46,720,135...46,725,962
Ensembl chr10:46,717,197...46,725,920

1,10-phenanthroline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl aminopeptidase, membrane

decreases activity
multiple interactions

1,10-phenanthroline results in decreased activity of ANPEP protein
Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein]

NCBI chr 7:55,351,081...55,373,856
Ensembl chr 7:55,351,087...55,373,881

G

glutamyl aminopeptidase

multiple interactions

1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]

NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510

1,3-benzothiazole-2-thiol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

thyroid peroxidase

decreases activity

captax results in decreased activity of TPO protein

PMID:23959146 PMID:25953703

NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208

1,3-thiazolidine-2,4-dione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 6

multiple interactions

2,4-thiazolidinedione inhibits the reaction [Linoleic Acid results in increased expression of IL6 protein]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]

PMID:14519784 PMID:15226458

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

peroxisome proliferator activated receptor gamma

multiple interactions

2,4-thiazolidinedione binds to and results in increased activity of PPARG protein

NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

2,4-thiazolidinedione inhibits the reaction [Linoleic Acid results in increased activity of RELA protein]

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

tumor necrosis factor

multiple interactions

[2,4-thiazolidinedione co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]]

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

G

vascular cell adhesion molecule 1

multiple interactions

[Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]]

NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222

1-(5-isoquinolinesulfonyl)-2-methylpiperazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]

NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554

1-chloro-2,4-dinitrobenzene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione S-transferase P-like

affects metabolic processing

GSTP1 protein affects the metabolism of Dinitrochlorobenzene

NCBI chr 2:5,005,498...5,009,247

1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenylate cyclase activating polypeptide 1

multiple interactions

1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid]

NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294

G

guanylate cyclase 1 soluble subunit alpha 1

multiple interactions
increases degradation

BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein]

NCBI chr 8:44,448,758...44,520,737
Ensembl chr 8:44,449,290...44,518,135

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions
increases degradation

BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein]; zinc protoporphyrin inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein]

NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,687

2,4-dinitrophenol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-microglobulin/bikunin precursor

decreases uptake

2,4-Dinitrophenol results in decreased uptake of AMBP protein

NCBI chr 1:254,683,885...254,703,220
Ensembl chr 1:254,683,891...254,703,225

G

nitric oxide synthase 3

increases expression

2,4-Dinitrophenol results in increased expression of NOS3 mRNA

NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943

2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

multiple interactions

Verapamil inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines]

NCBI chr 9:93,171,371...93,262,124

2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

multiple interactions

Itraconazole inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines]

NCBI chr 9:93,171,371...93,262,124

3',5'-cyclic AMP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATPase copper transporting beta

multiple interactions

Cyclic AMP inhibits the reaction [Copper binds to ATP7B protein]

NCBI chr11:15,892,549...15,942,070
Ensembl chr11:15,876,612...15,942,064

G

calcitonin-related polypeptide beta

increases abundance

CALCA protein results in increased abundance of Cyclic AMP

NCBI chr 2:44,043,135...44,048,651

G

dual oxidase 2

increases expression

Cyclic AMP results in increased expression of DUOX2 mRNA

NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,510...126,641,406

G

glucagon

affects response to substance
increases abundance

Cyclic AMP affects the susceptibility to GCG protein
GCG protein results in increased abundance of Cyclic AMP

NCBI chr15:68,800,557...68,810,268
Ensembl chr15:68,800,560...68,810,242

G

gonadotropin releasing hormone 1

multiple interactions
increases abundance

[Cobalt binds to GNRH1 protein] which results in increased abundance of Cyclic AMP
GNRH1 protein results in increased abundance of Cyclic AMP

NCBI chr14:9,442,971...9,447,521
Ensembl chr14:9,442,971...9,453,035

3',5'-cyclic GMP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

phosphodiesterase 5A

increases degradation

PDE5 protein results in increased degradation of Cyclic GMP

NCBI chr 8:104,270,858...104,420,955
Ensembl chr 8:104,270,881...104,420,953

G

phosphodiesterase 6C

increases degradation

PDE6C protein results in increased degradation of Cyclic GMP

NCBI chr14:105,010,974...105,122,628
Ensembl chr14:105,050,691...105,122,421

G

protein kinase cGMP-dependent 1

increases activity

Cyclic GMP results in increased activity of PRKG1 protein

NCBI chr14:97,558,531...98,793,080
Ensembl chr14:97,558,533...98,793,010

3-[3-(tert-butylsulfanyl)-1-(4-chlorobenzyl)-5-(propan-2-yl)-1H-indol-2-yl]-2,2-dimethylpropanoic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arachidonate 5-lipoxygenase activating protein

multiple interactions

MK-886 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein]

NCBI chr11:7,371,328...7,438,111
Ensembl chr11:7,411,644...7,438,108

G

caspase 3

multiple interactions

MK-886 inhibits the reaction [aristolochic acid I results in increased cleavage of and results in increased activity of CASP3 protein]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hypoxia inducible factor 1 subunit alpha

multiple interactions

bisindolylmaleimide I inhibits the reaction [sodium arsenite results in increased expression of HIF1A mRNA]

NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845

G

vascular endothelial growth factor A

multiple interactions

bisindolylmaleimide I inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]

NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366

3-methyladenine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BAX mRNA]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

beclin 1

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]; 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BECN1 protein]

PMID:28803810 PMID:34811946

NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373

G

caspase 3

multiple interactions

3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]

PMID:28803810 PMID:30287338

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 8

multiple interactions

3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP8 protein]

NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468

G

catalase

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the activity of CAT protein]

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

cytochrome c, somatic

multiple interactions

3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of CYCS mRNA]

NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866

G

dynactin subunit 4

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]

NCBI chr 2:151,681,001...151,713,923
Ensembl chr 2:151,681,003...151,783,746

G

FYVE, RhoGEF and PH domain containing 4

multiple interactions

3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L protein]]

NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028

G

fission, mitochondrial 1

multiple interactions

3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]

NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,937,453...8,946,955

G

glutathione peroxidase 1

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

lysosomal associated membrane protein 2

decreases expression

3-methyladenine results in decreased expression of LAMP2 protein

NCBI chr X:98,586,718...98,623,939
Ensembl chr X:98,581,992...98,623,940

G

microtubule associated protein 1 light chain 3 beta

multiple interactions
decreases lipidation

3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]; Benzo(a)pyrene promotes the reaction [3-methyladenine results in decreased lipidation of MAP1LC3B protein]

PMID:34811946 PMID:36754226

NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069

G

marker of proliferation Ki-67

multiple interactions

3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of MKI67 protein]]

NCBI chr14:137,266,622...137,296,312

G

MYD88 innate immune signal transduction adaptor

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the activity of CAT protein]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of MKI67 protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of TOMM20 protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of PARP1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]]

NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109

G

OPA1 mitochondrial dynamin like GTPase

multiple interactions

3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]

NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083

G

poly(ADP-ribose) polymerase 1

multiple interactions

3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of PARP1 protein]]; 3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein]

PMID:30287338 PMID:34811946

NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196

G

superoxide dismutase 1

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

sequestosome 1

multiple interactions

3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]; 3-methyladenine inhibits the reaction [Zinc Sulfate results in decreased expression of SQSTM1 protein]

PMID:28803810 PMID:34811946

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

translocase of outer mitochondrial membrane 20

multiple interactions

3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of TOMM20 protein]]

NCBI chr14:56,113,087...56,127,686
Ensembl chr14:56,113,192...56,127,677

G

tumor protein p53

multiple interactions

3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]]

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 19A3

multiple interactions

Fadrozole inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of and results in increased activity of CYP19A1 protein]

NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899

4-hydroxy-TEMPO

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

NFE2 like bZIP transcription factor 2

multiple interactions

tempol inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

xanthine dehydrogenase

multiple interactions

tempol inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; tempol results in decreased activity of [Hypoxanthine co-treated with XDH protein]

NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169

4-nitrocatechol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 2 subfamily E member 1

multiple interactions

2-aminoacetophenone inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol; Skatole inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]

NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817

4-nitrophenol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 2 subfamily E member 1

multiple interactions
increases hydroxylation

2-aminoacetophenone inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; 2-aminoacetophenone inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]; [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol; Skatole inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; Skatole inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]

NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817

5-(2-methylpiperazine-1-sulfonyl)isoquinoline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]

NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554

5-aza-2'-deoxycytidine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

DNA methyltransferase 1

multiple interactions

Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 protein]

PMID:29080797 PMID:30923867

NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844

G

H2A.X variant histone

multiple interactions

Decitabine inhibits the reaction [ochratoxin A results in increased expression of H2AX protein]

NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084

G

Janus kinase 2

multiple interactions
decreases phosphorylation

Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of JAK2 protein]
Decitabine results in decreased phosphorylation of JAK2 protein

NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148

G

nei like DNA glycosylase 1

multiple interactions
increases expression

Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]
Decitabine results in increased expression of NEIL1 mRNA

NCBI chr 7:58,261,761...58,269,001
Ensembl chr 7:58,261,769...58,268,522

G

nei like DNA glycosylase 3

multiple interactions
increases expression

Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]
Decitabine results in increased expression of NEIL3 mRNA

NCBI chr15:39,416,073...39,632,313
Ensembl chr15:39,581,856...39,632,308

G

8-oxoguanine DNA glycosylase

increases expression
multiple interactions

Decitabine results in increased expression of OGG1 mRNA
Decitabine inhibits the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]

NCBI chr13:66,038,669...66,045,478

G

suppressor of cytokine signaling 3

multiple interactions

Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 mRNA]; Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 protein]

NCBI chr12:3,643,832...3,647,015
Ensembl chr12:3,643,929...3,647,009

G

signal transducer and activator of transcription 3

multiple interactions

Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of STAT3 protein]

NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992

5-methyl-pyrazole-3-carboxylic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

D-amino acid oxidase

decreases activity

5-methylpyrazole-3-carboxylic acid results in decreased activity of DAO protein

NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,931,541...41,950,633

6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 1 subfamily A member 2

increases expression

6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP1A2 mRNA

NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100

6-anilino-5,8-quinolinedione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

superoxide dismutase 1

multiple interactions

SOD1 protein affects the susceptibility to [Ditiocarb co-treated with 6-anilino-5,8-quinolinedione]

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

sirtuin 1

multiple interactions

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]

NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,167...71,123,297

6-propyl-2-thiouracil

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

thyroid peroxidase

decreases activity

Propylthiouracil results in decreased activity of TPO protein

NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208

acifluorfen

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

protoporphyrinogen oxidase

decreases activity

acifluorfen results in decreased activity of PPOX protein

NCBI chr 4:89,277,984...89,288,946
Ensembl chr 4:89,284,500...89,288,902

acrylamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calcitonin-related polypeptide beta

increases expression

Acrylamide results in increased expression of CALCA protein

NCBI chr 2:44,043,135...44,048,651

G

interleukin 6

increases expression

Acrylamide results in increased expression of IL6 protein

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

interleukin-1 beta-like

increases expression

Acrylamide results in increased expression of IL1B protein

G

tachykinin precursor 1

increases expression

Acrylamide results in increased expression of TAC1 protein modified form

NCBI chr 9:77,197,403...77,206,529
Ensembl chr 9:77,197,536...77,206,523

G

tumor necrosis factor

increases expression

Acrylamide results in increased expression of TNF protein

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

G

vasoactive intestinal peptide

increases expression

Acrylamide results in increased expression of VIP protein

NCBI chr 1:13,611,786...13,620,250
Ensembl chr 1:13,611,311...13,620,269

actinomycin D

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calpain 1

multiple interactions

Dactinomycin inhibits the reaction [Oxygen deficiency results in increased expression of CAPN1 mRNA]

NCBI chr 2:6,997,513...7,024,410
Ensembl chr 2:6,997,985...7,022,684

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Dactinomycin inhibits the reaction [Mercuric Chloride results in increased expression of FOS mRNA]

NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Dactinomycin inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; Dactinomycin inhibits the reaction [Cadmium results in increased expression of HSPA5 protein]

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

adenosine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

myosin light chain 9

decreases phosphorylation
multiple interactions

Adenosine results in decreased phosphorylation of MYL9 protein
8-phenyltheophylline inhibits the reaction [Adenosine results in decreased phosphorylation of MYL9 protein]

NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,293

ageladine A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

casein kinase 1 alpha 1

decreases activity
affects activity

Ageladine A analog results in decreased activity of CSNK1A1 protein
Ageladine A affects the activity of CSNK1A1 protein

NCBI chr 2:150,612,845...150,662,431
Ensembl chr 2:150,612,077...150,662,284

alachlor

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 2C49

decreases response to substance

CYP2C49 protein results in decreased susceptibility to alachlor

NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455

alpha-(methylamino)isobutyric acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

insulin

increases uptake
multiple interactions

INS protein results in increased uptake of 2-(methylamino)isobutyric acid
Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]]; oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]

NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841

amastatin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutamyl aminopeptidase

multiple interactions

amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]

NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510

amiloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CF transmembrane conductance regulator

increases activity

Amiloride results in increased activity of CFTR protein

NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950

G

plasminogen activator, urokinase

multiple interactions

Amiloride inhibits the reaction [[Asbestos, Crocidolite results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [[Asbestos, Serpentine results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]

NCBI chr14:76,629,313...76,635,173
Ensembl chr14:76,629,299...76,635,172

G

plasminogen

multiple interactions

Amiloride inhibits the reaction [[Asbestos, Crocidolite results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [[Asbestos, Serpentine results in increased activity of PLAU protein] which results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [Asbestos, Crocidolite results in increased cleavage of PLG protein]; Amiloride inhibits the reaction [Asbestos, Serpentine results in increased cleavage of PLG protein]

NCBI chr 1:7,062,399...7,109,521
Ensembl chr 1:7,061,192...7,110,555

G

solute carrier family 2 member 1

multiple interactions

Amiloride promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA]

NCBI chr 6:168,535,398...168,561,170
Ensembl chr 6:168,535,440...168,560,867

amino acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

claudin 3

multiple interactions

Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN3 protein]

NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102

G

claudin 4

multiple interactions

Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN4 protein]

NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925

G

solute carrier family 1 member 1

increases expression

Amino Acids results in increased expression of SLC1A1 mRNA; Amino Acids results in increased expression of SLC1A1 protein

NCBI chr 1:217,366,493...217,441,643
Ensembl chr 1:217,366,499...217,441,674

G

tight junction protein 2

multiple interactions

Amino Acids inhibits the reaction [Diquat results in decreased expression of TJP2 protein]

NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983

G

tight junction protein 3

multiple interactions

Amino Acids inhibits the reaction [Diquat results in decreased expression of TJP3 protein]

NCBI chr 2:74,938,153...74,971,431
Ensembl chr 2:74,938,152...74,971,531

aminoglutethimide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ghrelin and obestatin prepropeptide

multiple interactions

Aminoglutethimide promotes the reaction [GHRL protein results in decreased secretion of Progesterone]

NCBI chr13:66,442,106...66,453,576
Ensembl chr13:66,445,992...66,452,917

ammonia

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ABI family member 3 binding protein

decreases expression

Ammonia results in decreased expression of ABI3BP mRNA

NCBI chr13:158,013,704...158,291,093
Ensembl chr13:158,013,726...158,291,103

G

albumin

increases expression

Ammonia results in increased expression of ALB mRNA

NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696

G

ankyrin repeat and sterile alpha motif domain containing 1A

increases expression

Ammonia results in increased expression of ANKS1A mRNA

NCBI chr 7:30,812,925...30,995,369
Ensembl chr 7:30,812,920...30,995,360

G

apolipoprotein B

increases expression

Ammonia results in increased expression of APOB mRNA

NCBI chr 3:117,250,096...117,316,200
Ensembl chr 3:117,250,096...117,316,200

G

apolipoprotein C3

increases expression

Ammonia results in increased expression of APOC3 mRNA

NCBI chr 9:44,211,171...44,213,538
Ensembl chr 9:44,211,194...44,213,533

G

apolipoprotein H

increases expression

Ammonia results in increased expression of APOH mRNA

NCBI chr12:12,827,195...12,839,172
Ensembl chr12:12,827,201...12,839,175

G

asparaginase and isoaspartyl peptidase 1

increases expression

Ammonia results in increased expression of ASRGL1 mRNA

NCBI chr 2:9,328,260...9,353,384
Ensembl chr 2:9,328,269...9,353,340

G

activating transcription factor 3

increases expression

Ammonia results in increased expression of ATF3 mRNA

NCBI chr 9:130,772,259...130,829,678
Ensembl chr 9:130,772,262...130,785,506

G

vasopressin

increases expression

Ammonia results in increased expression of AVP mRNA

NCBI chr17:32,581,234...32,583,145
Ensembl chr17:32,581,234...32,583,185

G

bone morphogenetic protein 4

decreases expression

Ammonia results in decreased expression of BMP4 mRNA

NCBI chr 1:183,415,989...183,422,888
Ensembl chr 1:183,416,146...183,422,637

G

bactericidal permeability increasing protein

increases expression

Ammonia results in increased expression of BPI mRNA

NCBI chr17:41,344,878...41,392,103
Ensembl chr17:41,344,939...41,392,100

G

BTG anti-proliferation factor 2

increases expression

Ammonia results in increased expression of BTG2 mRNA

NCBI chr 9:64,033,853...64,037,795
Ensembl chr 9:64,031,832...64,035,837

G

complement C7

decreases expression

Ammonia results in decreased expression of C7 mRNA

NCBI chr16:25,846,860...25,902,707
Ensembl chr16:25,846,860...25,903,980

G

carbonic anhydrase 12

decreases expression

Ammonia results in decreased expression of CA12 mRNA

NCBI chr 1:108,649,277...108,710,658
Ensembl chr 1:108,649,271...108,710,651

G

calcium binding and coiled-coil domain 1

decreases expression

Ammonia results in decreased expression of CALCOCO1 mRNA

NCBI chr 5:18,910,698...18,930,402
Ensembl chr 5:18,910,700...18,930,321

G

carnosine synthase 1

increases expression

Ammonia results in increased expression of CARNS1 mRNA

NCBI chr 2:5,097,238...5,105,697
Ensembl chr 2:5,097,243...5,105,696

G

coiled-coil domain containing 158

increases expression

Ammonia results in increased expression of CCDC158 mRNA

NCBI chr 8:71,990,113...72,088,966
Ensembl chr 8:71,990,119...72,088,829

G

C-C motif chemokine ligand 16

increases expression

Ammonia results in increased expression of CCL16 mRNA

NCBI chr12:39,618,187...39,621,557
Ensembl chr12:39,618,414...39,621,409

G

C-C motif chemokine receptor 2

decreases expression

Ammonia results in decreased expression of CCR2 mRNA

NCBI chr13:29,368,735...29,374,564
Ensembl chr13:29,369,122...29,376,343

G

CD3 epsilon subunit of T-cell receptor complex

decreases expression

Ammonia results in decreased expression of CD3E mRNA

NCBI chr 9:45,619,730...45,633,972
Ensembl chr 9:45,619,482...45,633,968

G

carnitine palmitoyltransferase 1A

decreases expression

Ammonia results in decreased expression of CPT1A mRNA

NCBI chr 2:4,250,642...4,293,914
Ensembl chr 2:4,233,099...4,293,911

G

C-X-C motif chemokine ligand 10

decreases expression

Ammonia results in decreased expression of CXCL10 mRNA

NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948

G

C-X-C motif chemokine ligand 11

decreases expression

Ammonia results in decreased expression of CXCL11 mRNA

NCBI chr 8:71,713,790...71,725,669
Ensembl chr 8:71,713,803...71,725,674

G

C-X-C motif chemokine ligand 14

decreases expression

Ammonia results in decreased expression of CXCL14 mRNA

NCBI chr 2:137,803,988...137,813,118
Ensembl chr 2:137,803,992...137,813,118

G

C-X-C motif chemokine ligand 9

decreases expression

Ammonia results in decreased expression of CXCL9 mRNA

NCBI chr 8:71,665,541...71,670,236
Ensembl chr 8:71,663,501...71,670,271

G

cytochrome P450 family 1 subfamily A member 1

decreases expression

Ammonia results in decreased expression of CYP1A1 mRNA

NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775

G

cytochrome P450 family 1 subfamily B member 1

decreases expression

Ammonia results in decreased expression of CYP1B1 mRNA

NCBI chr 3:102,195,743...102,205,687
Ensembl chr 3:102,195,741...102,205,683

G

cytochrome P450 2C49

increases expression

Ammonia results in increased expression of CYP2C49 mRNA

NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455

G

cytochrome P450 family 2 subfamily E member 1

increases expression

Ammonia results in increased expression of CYP2E1 mRNA

NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817

G

cytochrome P450 3A39

increases expression

Ammonia results in increased expression of CYP3A39 mRNA

G

DAB2 interacting protein

decreases expression

Ammonia results in decreased expression of DAB2IP mRNA

NCBI chr 1:261,732,280...261,859,833
Ensembl chr 1:261,659,785...261,859,830

G

DDB1 and CUL4 associated factor 8

increases expression

Ammonia results in increased expression of DCAF8 mRNA

NCBI chr 4:90,214,916...90,263,259
Ensembl chr 4:90,214,973...90,261,737

G

defective in cullin neddylation 1 domain containing 1

decreases expression

Ammonia results in decreased expression of DCUN1D1 mRNA

NCBI chr13:120,914,001...120,950,825

G

DEAD-box helicase 20

decreases expression

Ammonia results in decreased expression of DDX20 mRNA

NCBI chr 4:108,625,121...108,636,382
Ensembl chr 4:108,624,987...108,647,342

G

dimethylglycine dehydrogenase

decreases expression

Ammonia results in decreased expression of DMGDH mRNA

NCBI chr 2:87,791,827...87,867,189
Ensembl chr 2:87,791,943...87,866,679

G

dedicator of cytokinesis 2

decreases expression

Ammonia results in decreased expression of DOCK2 mRNA

NCBI chr16:53,843,248...54,248,708
Ensembl chr16:53,843,252...54,248,638

G

dual oxidase 2

decreases expression

Ammonia results in decreased expression of DUOX2 mRNA

NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,510...126,641,406

G

dual specificity phosphatase 1

increases expression

Ammonia results in increased expression of DUSP1 mRNA

NCBI chr16:51,457,924...51,461,095
Ensembl chr16:51,458,020...51,461,086

G

early growth response 1

increases expression

Ammonia results in increased expression of EGR1 mRNA

NCBI chr 2:140,440,829...140,445,302
Ensembl chr 2:140,441,421...140,445,296

G

coagulation factor XII

decreases expression

Ammonia results in decreased expression of F12 mRNA

NCBI chr 2:80,527,451...80,544,835
Ensembl chr 2:80,527,446...80,544,828

G

family with sequence similarity 177 member A1

decreases expression

Ammonia results in decreased expression of FAM177A1 mRNA

NCBI chr 7:64,788,829...64,808,640
Ensembl chr 7:64,788,077...64,808,473

G

family with sequence similarity 180 member B

decreases expression

Ammonia results in decreased expression of FAM180B mRNA

NCBI chr 2:15,027,360...15,029,999
Ensembl chr 2:15,027,362...15,029,982

G

Fc fragment of IgG, high affinity Ia, receptor (CD64)

decreases expression

Ammonia results in decreased expression of FCGR1A mRNA

NCBI chr 4:99,233,632...99,242,531
Ensembl chr 4:99,233,611...99,242,586

G

fibrinogen alpha chain

increases expression

Ammonia results in increased expression of FGA mRNA

NCBI chr 8:74,574,870...74,584,202
Ensembl chr 8:74,574,882...74,584,202

G

fibrinogen beta chain

increases expression

Ammonia results in increased expression of FGB mRNA

NCBI chr 8:74,598,170...74,607,409
Ensembl chr 8:74,595,688...74,607,409

G

fibrinogen gamma chain

increases expression

Ammonia results in increased expression of FGG mRNA

NCBI chr 8:74,553,040...74,562,151
Ensembl chr 8:74,553,105...74,563,688

G

folliculin interacting protein 1

increases expression

Ammonia results in increased expression of FNIP1 mRNA

NCBI chr 2:133,958,112...134,093,408
Ensembl chr 2:133,957,553...134,093,413

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

Ammonia results in increased expression of FOS mRNA

NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

Ammonia results in increased expression of FOSB mRNA

NCBI chr 6:51,836,780...51,844,531
Ensembl chr 6:51,837,719...51,844,529

G

forkhead box J1

increases expression

Ammonia results in increased expression of FOXJ1 mRNA

NCBI chr12:5,307,370...5,312,117
Ensembl chr12:5,307,374...5,312,106

G

golgi reassembly stacking protein 1

increases expression

Ammonia results in increased expression of GORASP1 mRNA

NCBI chr13:23,786,245...23,797,508
Ensembl chr13:23,786,248...23,797,487

G

G protein-coupled receptor 182

increases expression

Ammonia results in increased expression of GPR182 mRNA

NCBI chr 5:22,303,466...22,309,652
Ensembl chr 5:22,304,588...22,311,028

G

granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)

decreases expression

Ammonia results in decreased expression of GZMA mRNA

NCBI chr16:34,282,160...34,290,422
Ensembl chr16:34,282,120...34,290,477

G

hepatocyte nuclear factor 4 gamma

increases expression

Ammonia results in increased expression of HNF4G mRNA

NCBI chr 4:60,505,388...60,641,052
Ensembl chr 4:60,505,385...60,595,789

G

15-hydroxyprostaglandin dehydrogenase

decreases expression

Ammonia results in decreased expression of HPGD mRNA

NCBI chr14:15,718,261...15,773,534
Ensembl chr14:15,718,678...15,760,767

G

hemopexin

increases expression

Ammonia results in increased expression of HPX mRNA

NCBI chr 9:3,288,288...3,297,051
Ensembl chr 9:3,288,172...3,297,047

G

interleukin 4 receptor

increases expression

Ammonia results in increased expression of IL4R mRNA

NCBI chr 3:19,526,343...19,576,792
Ensembl chr 3:19,523,564...19,576,544

G

inositol-trisphosphate 3-kinase B

decreases expression

Ammonia results in decreased expression of ITPKB mRNA

NCBI chr10:14,362,883...14,469,586

G

potassium voltage-gated channel subfamily A regulatory beta subunit 1

increases expression

Ammonia results in increased expression of KCNAB1 mRNA

NCBI chr13:95,981,820...96,375,089
Ensembl chr13:95,959,378...96,375,856

G

potassium two pore domain channel subfamily K member 5

increases expression

Ammonia results in increased expression of KCNK5 mRNA

NCBI chr 7:34,617,948...34,656,705
Ensembl chr 7:34,617,956...34,656,697

G

lysine demethylase 5A

increases expression

Ammonia results in increased expression of KDM5A mRNA

NCBI chr 5:67,628,791...67,716,143
Ensembl chr 5:67,629,380...67,715,905

G

lysine demethylase 5C

decreases expression

Ammonia results in decreased expression of KDM5C mRNA

NCBI chr X:45,968,812...46,003,215
Ensembl chr X:45,968,814...46,003,215

G

kinesin family member 20A

increases expression

Ammonia results in increased expression of KIF20A mRNA

NCBI chr 2:140,202,316...140,213,144
Ensembl chr 2:140,202,015...140,211,155

G

KRAS proto-oncogene, GTPase

increases expression

Ammonia results in increased expression of KRAS mRNA

NCBI chr 5:48,508,774...48,546,260
Ensembl chr 5:48,508,811...48,549,358

G

lymphocyte transmembrane adaptor 1

decreases expression

Ammonia results in decreased expression of LAX1 mRNA

NCBI chr 9:64,460,548...64,473,232
Ensembl chr 9:64,460,693...64,473,621

G

muscleblind like splicing regulator 2

decreases expression

Ammonia results in decreased expression of MBNL2 mRNA

NCBI chr11:66,481,923...66,641,653
Ensembl chr11:66,481,923...66,641,653

G

methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like

decreases expression

Ammonia results in decreased expression of MTHFD1L mRNA

NCBI chr 1:15,140,929...15,330,265
Ensembl chr 1:15,140,899...15,329,986

G

5-methyltetrahydrofolate-homocysteine methyltransferase reductase

increases expression

Ammonia results in increased expression of MTRR mRNA

NCBI chr16:74,245,214...74,270,828
Ensembl chr16:74,245,228...74,270,783

G

MYB binding protein 1a

decreases expression

Ammonia results in decreased expression of MYBBP1A mRNA

NCBI chr12:50,491,042...50,506,085
Ensembl chr12:50,491,044...50,506,050

G

nucleus accumbens associated 1

decreases expression

Ammonia results in decreased expression of NACC1 mRNA

NCBI chr 2:65,920,352...65,938,840
Ensembl chr 2:65,922,126...65,938,759

G

nuclear receptor coactivator 1

increases expression

Ammonia results in increased expression of NCOA1 mRNA

NCBI chr 3:113,997,214...114,251,080
Ensembl chr 3:113,999,253...114,250,298

G

neuralized E3 ubiquitin protein ligase 1

decreases expression

Ammonia results in decreased expression of NEURL1 mRNA

NCBI chr14:114,436,887...114,515,713
Ensembl chr14:114,437,045...114,516,721

G

nuclear factor I X

decreases expression

Ammonia results in decreased expression of NFIX mRNA

NCBI chr 2:65,954,808...66,056,591
Ensembl chr 2:65,954,811...66,056,567

G

nuclear receptor subfamily 4 group A member 2

increases expression

Ammonia results in increased expression of NR4A2 mRNA

NCBI chr15:63,487,051...63,506,249
Ensembl chr15:63,487,731...63,495,299

G

neuronal regeneration related protein

increases expression

Ammonia results in increased expression of NREP mRNA

NCBI chr 2:117,505,851...117,867,805
Ensembl chr 2:117,838,660...117,867,801

G

prolyl 4-hydroxylase subunit alpha 1

decreases expression

Ammonia results in decreased expression of P4HA1 mRNA

NCBI chr14:75,827,207...75,919,121
Ensembl chr14:75,825,148...75,919,016

G

phosphate cytidylyltransferase 1A, choline

decreases expression

Ammonia results in decreased expression of PCYT1A mRNA

NCBI chr13:133,794,337...133,851,004
Ensembl chr13:133,818,761...133,850,996

G

proline rich acidic protein 1

decreases expression

Ammonia results in decreased expression of PRAP1 mRNA

NCBI chr14:141,325,965...141,329,955

G

protein tyrosine phosphatase receptor type C

decreases expression

Ammonia results in decreased expression of PTPRC mRNA

NCBI chr10:21,482,984...21,601,627
Ensembl chr10:21,560,073...21,601,308

G

RAS like proto-oncogene B

increases expression

Ammonia results in increased expression of RALB mRNA

NCBI chr15:31,064,341...31,118,437
Ensembl chr15:31,064,355...31,122,621

G

RAS like family 12

decreases expression

Ammonia results in decreased expression of RASL12 mRNA

NCBI chr 1:163,089,440...163,104,027
Ensembl chr 1:163,089,444...163,103,523

G

RB transcriptional corepressor like 2

decreases expression

Ammonia results in decreased expression of RBL2 mRNA

NCBI chr 6:31,757,718...31,802,047
Ensembl chr 6:31,748,739...31,802,022

G

retinol binding protein 4

increases expression

Ammonia results in increased expression of RBP4 mRNA

NCBI chr14:105,037,360...105,044,552
Ensembl chr14:105,037,464...105,044,765

G

recombination signal binding protein for immunoglobulin kappa J region

decreases expression

Ammonia results in decreased expression of RBPJ mRNA

NCBI chr 8:19,933,035...20,166,746
Ensembl chr 8:19,922,779...20,166,754

G

replication factor C subunit 1

decreases expression

Ammonia results in decreased expression of RFC1 mRNA

NCBI chr 8:30,552,369...30,635,932
Ensembl chr 8:30,552,400...30,635,867

G

salivary lipocalin

increases expression

Ammonia results in increased expression of SAL1 mRNA

NCBI chr 1:253,638,017...253,642,835
Ensembl chr 1:253,638,015...253,642,866

G

stearoyl-CoA desaturase

decreases expression

Ammonia results in decreased expression of SCD mRNA

NCBI chr14:111,461,560...111,478,033
Ensembl chr14:111,461,569...111,478,020

G

secreted frizzled related protein 2

decreases expression

Ammonia results in decreased expression of SFRP2 mRNA

NCBI chr 8:75,337,311...75,345,926
Ensembl chr 8:75,337,144...75,345,921

G

secreted frizzled related protein 4

decreases expression

Ammonia results in decreased expression of SFRP4 mRNA

NCBI chr 9:108,404,314...108,414,335
Ensembl chr 9:108,404,040...108,414,307

G

solute carrier family 13 member 4

decreases expression

Ammonia results in decreased expression of SLC13A4 mRNA

NCBI chr18:13,593,735...13,641,649
Ensembl chr18:13,593,756...13,636,180

G

solute carrier family 22 member 7

increases expression

Ammonia results in increased expression of SLC22A7 mRNA

NCBI chr 7:38,328,474...38,334,879
Ensembl chr 7:38,328,419...38,334,878

G

solute carrier family 25 member 12

increases expression

Ammonia results in increased expression of SLC25A12 mRNA

NCBI chr15:77,895,935...78,021,930
Ensembl chr15:77,895,938...78,098,383

G

solute carrier family 46 member 3

decreases expression

Ammonia results in decreased expression of SLC46A3 mRNA

NCBI chr11:5,983,198...6,000,728
Ensembl chr11:5,982,443...6,000,701

G

solute carrier family 47 member 1

increases expression

Ammonia results in increased expression of SLC47A1 mRNA

NCBI chr12:60,021,176...60,114,488
Ensembl chr12:60,021,188...60,056,938

G

solute carrier family 7 member 8

decreases expression

Ammonia results in decreased expression of SLC7A8 mRNA

NCBI chr 7:75,854,700...75,921,931
Ensembl chr 7:75,854,882...75,921,931

G

solute carrier family 9 member A3

decreases expression

Ammonia results in decreased expression of SLC9A3 mRNA

NCBI chr16:79,625,555...79,704,084
Ensembl chr16:79,666,825...79,700,658

G

slit guidance ligand 2

decreases expression

Ammonia results in decreased expression of SLIT2 mRNA

NCBI chr 8:14,758,426...15,149,515
Ensembl chr 8:14,758,335...15,148,133

G

superoxide dismutase 3

increases expression

Ammonia results in increased expression of SOD3 mRNA

NCBI chr 8:18,796,633...18,802,156
Ensembl chr 8:18,796,637...18,802,152

G

sortilin related VPS10 domain containing receptor 2

decreases expression

Ammonia results in decreased expression of SORCS2 mRNA

NCBI chr 8:3,207,087...3,715,002
Ensembl chr 8:3,207,098...3,760,393

G

steroid 5 alpha-reductase 2

increases expression

Ammonia results in increased expression of SRD5A2 mRNA

NCBI chr 3:107,840,200...107,918,351
Ensembl chr 3:107,840,200...107,918,350

G

ST3 beta-galactoside alpha-2,3-sialyltransferase 6

increases expression

Ammonia results in increased expression of ST3GAL6 mRNA

NCBI chr13:160,158,238...160,225,355
Ensembl chr13:160,158,259...160,224,819

G

transcription elongation factor A like 2

decreases expression

Ammonia results in decreased expression of TCEAL2 mRNA

NCBI chr X:83,577,181...83,582,946

G

transmembrane protein 33

increases expression

Ammonia results in increased expression of TMEM33 mRNA

NCBI chr 8:33,012,540...33,036,448
Ensembl chr 8:33,012,390...33,036,993

G

trafficking kinesin protein 2

increases expression

Ammonia results in increased expression of TRAK2 mRNA

NCBI chr15:104,991,261...105,056,054
Ensembl chr15:104,991,726...105,055,025

G

tetratricopeptide repeat domain 31

decreases expression

Ammonia results in decreased expression of TTC31 mRNA

NCBI chr 3:68,555,230...68,570,912
Ensembl chr 3:68,555,232...68,564,007

G

vacuolar protein sorting 36 homolog

decreases expression

Ammonia results in decreased expression of VPS36 mRNA

NCBI chr11:15,701,370...15,735,469
Ensembl chr11:15,701,373...15,735,474

G

vitronectin

increases expression

Ammonia results in increased expression of VTN mRNA

NCBI chr12:44,650,532...44,653,916
Ensembl chr12:44,650,534...44,655,355

G

WAPL cohesin release factor

decreases expression

Ammonia results in decreased expression of WAPL mRNA

NCBI chr14:87,492,452...87,588,678
Ensembl chr14:87,492,458...87,588,543

G

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta

decreases expression

Ammonia results in decreased expression of YWHAZ mRNA

NCBI chr 4:35,975,513...36,009,909
Ensembl chr 4:35,975,508...36,009,887

G

zinc finger protein 24

decreases expression

Ammonia results in decreased expression of ZNF24 mRNA

NCBI chr 6:119,156,507...119,167,240
Ensembl chr 6:119,160,530...119,167,187

G

zinc finger protein 436

decreases expression

Ammonia results in decreased expression of ZNF436 mRNA

NCBI chr 6:81,250,203...81,262,346
Ensembl chr 6:81,250,629...81,262,351

G

zinc finger protein 79

increases expression

Ammonia results in increased expression of ZNF79 mRNA

NCBI chr 1:267,941,953...267,959,754
Ensembl chr 1:267,942,101...267,966,192

ammonium chloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

RUNX family transcription factor 2

multiple interactions

Ammonium Chloride inhibits the reaction [SOX5 protein inhibits the reaction [Warfarin results in increased expression of RUNX2 mRNA]]

NCBI chr 7:40,106,581...40,353,304
Ensembl chr 7:40,106,532...40,460,687

G

SRY-box transcription factor 5

multiple interactions

Ammonium Chloride inhibits the reaction [SOX5 protein inhibits the reaction [Warfarin results in increased expression of RUNX2 mRNA]]

NCBI chr 5:49,159,950...50,166,463
Ensembl chr 5:49,504,551...50,161,558

amoxicillin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier organic anion transporter family member 1A2

increases uptake
multiple interactions

SLCO1A2 protein results in increased uptake of Amoxicillin
Amoxicillin inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; Amoxicillin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]

NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730

amprenavir

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nitric oxide synthase 3

decreases expression

amprenavir results in decreased expression of NOS3 mRNA

NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943

anthra[1,9-cd]pyrazol-6(2H)-one

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

pyrazolanthrone affects the reaction [etoxazole affects the phosphorylation of AKT1 protein]

G

BCL2 associated X, apoptosis regulator

multiple interactions

pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

BCL2 apoptosis regulator

multiple interactions

pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA]

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

caspase 3

multiple interactions

pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 9

multiple interactions

pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein]

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

chemokine (C-C motif) ligand 2

decreases expression
multiple interactions

pyrazolanthrone results in decreased expression of CCL2 mRNA
pyrazolanthrone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; pyrazolanthrone inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]

PMID:19265715 PMID:21176401 PMID:23380242

NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026

G

C-X-C motif chemokine ligand 8

decreases secretion
decreases expression

pyrazolanthrone results in decreased secretion of CXCL8 protein
pyrazolanthrone results in decreased expression of CXCL8 mRNA

NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861

G

fibronectin 1

multiple interactions

pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of FN1 protein]

NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,043

G

interferon gamma

decreases expression

pyrazolanthrone results in decreased expression of IFNG mRNA

NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670

G

interleukin 6

decreases expression

pyrazolanthrone results in decreased expression of IL6 mRNA

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

interleukin-1 beta-like

decreases secretion
decreases expression

pyrazolanthrone results in decreased secretion of IL1B protein
pyrazolanthrone results in decreased expression of IL1B mRNA

G

mitogen-activated protein kinase 1

multiple interactions

[pyrazolanthrone co-treated with etoxazole] results in increased phosphorylation of MAPK1 protein; pyrazolanthrone inhibits the reaction [Ivermectin results in decreased phosphorylation of MAPK1 protein]

PMID:31400776 PMID:31744678

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 3

multiple interactions

[pyrazolanthrone co-treated with etoxazole] results in increased phosphorylation of MAPK3 protein; pyrazolanthrone inhibits the reaction [Ivermectin results in decreased phosphorylation of MAPK3 protein]

PMID:31400776 PMID:31744678

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

mitogen-activated protein kinase 8

multiple interactions

pyrazolanthrone inhibits the reaction [etoxazole results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK8 protein]

PMID:31400776 PMID:31744678

NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874

G

mitogen-activated protein kinase 9

multiple interactions

pyrazolanthrone promotes the reaction [Ivermectin results in decreased phosphorylation of MAPK9 protein]

NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100

G

ribosomal protein S6

multiple interactions

pyrazolanthrone affects the reaction [etoxazole affects the phosphorylation of RPS6 protein]

NCBI chr 1:203,444,360...203,447,643
Ensembl chr 1:203,444,450...203,451,468

G

ribosomal protein S6 kinase A1

multiple interactions

pyrazolanthrone inhibits the reaction [Ivermectin results in decreased phosphorylation of RPS6KA1 protein]

NCBI chr 6:83,905,124...83,947,189
Ensembl chr 6:83,905,077...83,950,963

G

ribosomal protein S6 kinase B1

multiple interactions

pyrazolanthrone affects the reaction [etoxazole affects the phosphorylation of RPS6KB1 protein]

NCBI chr12:36,111,584...36,159,287
Ensembl chr12:36,111,653...36,160,376

G

serpin family E member 1

multiple interactions

pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of SERPINE1 protein]

NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,547

G

transforming growth factor beta 1

multiple interactions

pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of TGFB1 mRNA]

NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046

G

tumor necrosis factor

decreases expression

pyrazolanthrone results in decreased expression of TNF mRNA

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

G

vascular cell adhesion molecule 1

multiple interactions

pyrazolanthrone inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]

NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222

antimycin A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-microglobulin/bikunin precursor

decreases uptake

Antimycin A results in decreased uptake of AMBP protein

NCBI chr 1:254,683,885...254,703,220
Ensembl chr 1:254,683,891...254,703,225

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Antimycin A co-treated with Deoxyglucose] results in increased expression of BAX protein; Quercetin inhibits the reaction [[Antimycin A co-treated with Deoxyglucose] results in increased expression of BAX protein]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

mechanistic target of rapamycin kinase

multiple interactions

[Antimycin A co-treated with Deoxyglucose] results in decreased phosphorylation of MTOR protein; Quercetin promotes the reaction [[Antimycin A co-treated with Deoxyglucose] results in decreased phosphorylation of MTOR protein]

NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888

arecoline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

fibronectin 1

increases expression
multiple interactions

Arecoline results in increased expression of FN1 protein
pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of FN1 protein]

NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,043

G

serpin family E member 1

multiple interactions
increases expression

pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of SERPINE1 protein]

NCBI chr 3:8,863,738...8,871,572
Ensembl chr 3:8,863,695...8,871,547

G

transforming growth factor beta 1

multiple interactions
increases expression

Arecoline results in increased secretion of and results in increased activity of TGFB1 protein; pyrazolanthrone inhibits the reaction [Arecoline results in increased expression of TGFB1 mRNA]

NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046

aristolochic acid A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arachidonate 5-lipoxygenase activating protein

multiple interactions
increases expression

MK-886 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein]; U 0126 inhibits the reaction [aristolochic acid I results in increased expression of ALOX5AP protein]

NCBI chr11:7,371,328...7,438,111
Ensembl chr11:7,411,644...7,438,108

G

caspase 3

multiple interactions

aristolochic acid I results in increased cleavage of and results in increased activity of CASP3 protein; MK-886 inhibits the reaction [aristolochic acid I results in increased cleavage of and results in increased activity of CASP3 protein]; U 0126 inhibits the reaction [aristolochic acid I results in increased cleavage of and results in increased activity of CASP3 protein]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

leukotriene C4 synthase

decreases expression

aristolochic acid I results in decreased expression of LTC4S protein

NCBI chr 2:78,799,446...78,802,281
Ensembl chr 2:78,799,449...78,802,285

G

mitogen-activated protein kinase 1

multiple interactions

aristolochic acid I results in increased phosphorylation of and results in increased activity of MAPK1 protein; U 0126 inhibits the reaction [aristolochic acid I results in increased phosphorylation of and results in increased activity of MAPK1 protein]

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 3

multiple interactions

aristolochic acid I results in increased phosphorylation of and results in increased activity of MAPK3 protein; U 0126 inhibits the reaction [aristolochic acid I results in increased phosphorylation of and results in increased activity of MAPK3 protein]

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

microsomal glutathione S-transferase 3

multiple interactions
increases expression

U 0126 inhibits the reaction [aristolochic acid I results in increased expression of MGST3 protein]

NCBI chr 4:85,069,603...85,095,022
Ensembl chr 4:85,069,607...85,094,981

arsenous acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases expression

Arsenic Trioxide results in increased expression of CASP3

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

glutamate-cysteine ligase catalytic subunit

increases activity
increases expression

Arsenic Trioxide results in increased activity of GCLC protein
Arsenic Trioxide results in increased expression of GCLC mRNA

NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530

G

gamma-glutamyltransferase 1

increases expression
increases activity

Arsenic Trioxide results in increased expression of GGT1 mRNA
Arsenic Trioxide results in increased activity of GGT1 protein

NCBI chr14:49,618,737...49,638,054

G

tumor protein p53

increases expression

Arsenic Trioxide results in increased expression of TP53

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

aspartame

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutamyl aminopeptidase

multiple interactions
increases hydrolysis

1,10-phenanthroline inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; amastatin inhibits the reaction [ENPEP protein results in increased hydrolysis of Aspartame]; Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame]

NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510

ATP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 apoptosis regulator

increases expression
multiple interactions

Adenosine Triphosphate results in increased expression of BCL2 protein
tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased expression of BCL2 protein]

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

caspase 8

increases activity
multiple interactions

Adenosine Triphosphate results in increased activity of CASP8 protein
tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased activity of CASP8 protein]

NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468

G

cytochrome c, somatic

affects localization
multiple interactions

Adenosine Triphosphate affects the localization of CYCS protein
[Calcium co-treated with Phosphates co-treated with Adenosine Triphosphate] affects the localization of CYCS protein; tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate affects the localization of CYCS protein]

PMID:16489745 PMID:17997382

NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866

G

myosin light chain 9

decreases phosphorylation
multiple interactions

Adenosine Triphosphate results in decreased phosphorylation of MYL9 protein
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein]]; Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein]

NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,293

G

tumor necrosis factor

increases expression
multiple interactions

Adenosine Triphosphate results in increased expression of TNF protein
tetrakis(N-methyl-4-pyridiniumyl)porphine manganese(III) complex inhibits the reaction [Adenosine Triphosphate results in increased expression of TNF protein]

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

BAPTA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

myosin light chain 9

multiple interactions

1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Adenosine Triphosphate promotes the reaction [calyculin A results in increased phosphorylation of MYL9 protein]]; [Calcium co-treated with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid] results in decreased phosphorylation of MYL9 protein

NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,293

beauvericin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B (MDR/TAP), member 1

decreases activity
increases expression

beauvericin results in decreased activity of ABCB1 protein
beauvericin results in increased expression of ABCB1 mRNA

NCBI chr 9:93,049,955...93,146,469

G

cytochrome P450 family 11 subfamily A member 1

increases expression

beauvericin results in increased expression of CYP11A1 mRNA

NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478

G

mitochondrially encoded cytochrome c oxidase I

increases expression

beauvericin results in increased expression of COX1 mRNA

NCBI chr MT:6,511...8,055
Ensembl chr MT:6,511...8,055

Belnacasan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

gasdermin D

multiple interactions

belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD protein]

NCBI chr 4:995,753...1,001,964
Ensembl chr 4:995,763...1,000,271

G

interleukin 18

multiple interactions

belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 protein]

NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219

G

interleukin-1 beta-like

multiple interactions

belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B protein]

benazepril

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

kininogen 1

increases activity

benazepril results in increased activity of KNG1 protein modified form

NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958

benzamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 9 member A1

decreases activity

benzamide analog results in decreased activity of SLC9A1 protein

NCBI chr 6:84,373,921...84,426,447
Ensembl chr 6:84,372,649...84,426,997

benzamidoxime

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

molybdenum cofactor sulfurase

affects reduction

MOCOS protein affects the reduction of benzamidoxime

NCBI chr 6:119,945,076...120,018,332
Ensembl chr 6:119,945,052...120,018,097

benzothiazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

thyroid peroxidase

decreases activity

benzothiazole results in decreased activity of TPO protein

NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208

bethanechol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-X-C motif chemokine ligand 10

increases expression

Bethanechol results in increased expression of CXCL10 mRNA

NCBI chr 8:71,693,641...71,695,948
Ensembl chr 8:71,693,339...71,695,948

G

C-X-C motif chemokine ligand 8

increases expression

Bethanechol results in increased expression of CXCL8 mRNA

NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861

G

interferon gamma

increases expression

Bethanechol results in increased expression of IFNG mRNA

NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670

G

interleukin 17A

increases expression

Bethanechol results in increased expression of IL17A mRNA

NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153

G

interleukin 1 alpha

increases expression

Bethanechol results in increased expression of IL1A mRNA

NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,121

bezafibrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apolipoprotein A1

increases expression
increases secretion

Bezafibrate results in increased expression of APOA1 mRNA
Bezafibrate results in increased secretion of APOA1 protein

NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713

G

BCL2 associated X, apoptosis regulator

multiple interactions

Bezafibrate inhibits the reaction [Cisplatin affects the localization of BAX protein]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

BCL2 apoptosis regulator

increases expression

Bezafibrate results in increased expression of BCL2

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

caspase 3

multiple interactions

Bezafibrate inhibits the reaction [Cisplatin results in increased cleavage of and results in increased activity of CASP3 protein]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

cytochrome c, somatic

multiple interactions

Bezafibrate inhibits the reaction [Cisplatin affects the localization of CYCS protein]

NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866

G

lipase G, endothelial type

decreases expression

Bezafibrate results in decreased expression of LIPG mRNA; Bezafibrate results in decreased expression of LIPG protein

NCBI chr 1:99,081,940...99,110,671
Ensembl chr 1:99,081,938...99,110,874

G

peroxisome proliferator activated receptor alpha

multiple interactions

Bezafibrate inhibits the reaction [[Cisplatin results in decreased activity of PPARA protein] which results in increased abundance of Fatty Acids, Nonesterified]; Bezafibrate inhibits the reaction [Cisplatin results in decreased activity of PPARA protein]

NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239

G

scavenger receptor class B member 1

affects localization
increases expression

Bezafibrate affects the localization of SCARB1 protein
Bezafibrate results in increased expression of SCARB1 mRNA

NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,568

bilirubin IXalpha

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

Bilirubin inhibits the reaction [Excitatory Amino Acid Agents results in increased activity of CASP3 protein]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

growth hormone 1

multiple interactions

GH1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Bilirubin]

NCBI chr12:15,064,965...15,066,698
Ensembl chr12:15,064,909...15,066,696

brimonidine tartrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cAMP responsive element binding protein 1

increases phosphorylation
multiple interactions

Brimonidine Tartrate results in increased phosphorylation of CREB1 protein
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]

NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728

brucine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor muscarinic 2

multiple interactions

brucine analog promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]

NCBI chr18:12,455,139...12,600,314
Ensembl chr18:12,455,145...12,600,186

bucladesine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATPase Na+/K+ transporting subunit alpha 1

increases expression

Bucladesine results in increased expression of ATP1A1 protein

NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,506...104,384,680

Butyrylcholine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

increases hydrolysis

BCHE protein results in increased hydrolysis of butyrylcholine

NCBI chr13:104,946,732...105,007,568

butyrylthiocholine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

butyrylcholinesterase

increases hydrolysis

BCHE protein results in increased hydrolysis of Butyrylthiocholine

NCBI chr13:104,946,732...105,007,568

BW A868C

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nitric oxide synthase 3

multiple interactions
decreases expression

BW A868C inhibits the reaction [Prostaglandin D2 results in increased expression of NOS3 mRNA]; Prostaglandin D2 inhibits the reaction [BW A868C results in decreased expression of NOS3 mRNA]

NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943

cadmium nitrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

CD14 molecule

affects expression

cadmium nitrate affects the expression of CD14 mRNA

NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,360...142,349,581

G

C-X-C motif chemokine ligand 8

affects expression
affects secretion

cadmium nitrate affects the expression of CXCL8 mRNA
cadmium nitrate affects the secretion of CXCL8 protein

NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861

G

defensin beta 1

increases expression

cadmium nitrate results in increased expression of DEFB1 mRNA

G

interferon beta 1

increases expression

cadmium nitrate results in increased expression of IFNB1 mRNA

NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495

G

interleukin 18

increases expression

cadmium nitrate results in increased expression of IL18 mRNA

NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219

G

interleukin 6

increases expression

cadmium nitrate results in increased expression of IL6 mRNA

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

interleukin-1 beta-like

increases expression

cadmium nitrate results in increased expression of IL1B mRNA

G

mitogen-activated protein kinase 14

affects expression

cadmium nitrate affects the expression of MAPK14 mRNA

NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031

G

mitogen-activated protein kinase 8

increases expression

cadmium nitrate results in increased expression of MAPK8 mRNA

NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874

G

MYD88 innate immune signal transduction adaptor

affects expression

cadmium nitrate affects the expression of MYD88 mRNA

NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109

G

nuclear factor kappa B subunit 1

affects expression

cadmium nitrate affects the expression of NFKB1 mRNA

NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691

G

RELA proto-oncogene, NF-kB subunit

increases expression

cadmium nitrate results in increased expression of RELA mRNA

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

suppressor of cytokine signaling 1

decreases expression

cadmium nitrate results in decreased expression of SOCS1 mRNA

NCBI chr 3:31,879,143...31,883,041
Ensembl chr 3:31,881,225...31,884,967

G

signal transducer and activator of transcription 3

decreases expression

cadmium nitrate results in decreased expression of STAT3 mRNA

NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992

G

toll like receptor 4

affects expression

cadmium nitrate affects the expression of TLR4 mRNA

NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970

G

toll like receptor 5

increases expression

cadmium nitrate results in increased expression of TLR5 mRNA

NCBI chr10:19,387,666...19,410,024
Ensembl chr10:19,387,666...19,410,024

G

tumor necrosis factor

increases expression

cadmium nitrate results in increased expression of TNF mRNA

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

caffeine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATM serine/threonine kinase

multiple interactions

Caffeine inhibits the reaction [deoxynivalenol results in increased phosphorylation of ATM protein]

NCBI chr 9:36,620,656...36,759,555
Ensembl chr 9:36,620,657...36,759,552

G

cyclin B1

multiple interactions

Caffeine inhibits the reaction [deoxynivalenol results in decreased expression of CCNB1 protein]

NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,377

G

cell division cycle 25C

multiple interactions

Caffeine inhibits the reaction [deoxynivalenol results in decreased expression of CDC25C protein]

NCBI chr 2:140,289,156...140,323,696
Ensembl chr 2:140,289,115...140,324,425

G

cyclin dependent kinase 1

multiple interactions

Caffeine inhibits the reaction [deoxynivalenol results in decreased expression of CDK1 protein]

NCBI chr14:64,233,945...64,255,290
Ensembl chr14:64,233,987...64,372,197

G

checkpoint kinase 2

multiple interactions

Caffeine inhibits the reaction [deoxynivalenol results in increased phosphorylation of CHEK2 protein]

NCBI chr14:45,699,833...45,967,350
Ensembl chr14:45,929,715...45,967,290

G

ryanodine receptor 1

multiple interactions
increases activity

Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]; Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein mutant form]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein]
Caffeine results in increased activity of RYR1 protein; Caffeine results in increased activity of RYR1 protein mutant form

NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458

capsaicin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenylate cyclase activating polypeptide 1

multiple interactions

Capsaicin inhibits the reaction [ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid]

NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294

G

tachykinin precursor 1

increases secretion

Capsaicin results in increased secretion of TAC1 protein

NCBI chr 9:77,197,403...77,206,529
Ensembl chr 9:77,197,536...77,206,523

capsazepine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

transient receptor potential cation channel subfamily V member 1

multiple interactions

capsazepine inhibits the reaction [Sodium affects the reaction [TRPV1 protein results in increased abundance of Calcium]]

NCBI chr12:49,676,536...49,709,634
Ensembl chr12:49,677,291...49,713,977

CAR(3:0(Me2))

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 5

decreases activity

pivaloylcarnitine results in decreased activity of SLC22A5 protein

NCBI chr 2:134,660,741...134,847,575
Ensembl chr 2:134,660,808...134,686,219

carvedilol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cadherin 5

increases expression
decreases expression

Carvedilol results in increased expression of CDH5 protein
Carvedilol results in decreased expression of CDH5 mRNA

NCBI chr 6:27,108,560...27,142,145
Ensembl chr 6:27,108,597...27,142,177

G

catenin beta 1

decreases expression
increases expression

Carvedilol results in decreased expression of CTNNB1 mRNA
Carvedilol results in increased expression of CTNNB1 protein

NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311

G

endothelin 1

decreases expression
multiple interactions

Carvedilol results in decreased expression of EDN1 protein
Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein]

NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348

G

junction plakoglobin

decreases expression
increases expression

Carvedilol results in decreased expression of JUP mRNA
Carvedilol results in increased expression of JUP protein

NCBI chr12:20,902,395...20,931,208
Ensembl chr12:20,901,396...20,931,210

CCCP

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione peroxidase 4

multiple interactions

Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [Diquat results in decreased expression of GPX4 mRNA]

NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931

cefaloridine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

decreases activity

Cephaloridine results in decreased activity of CAT protein

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

chloroquine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

heat shock protein family D (Hsp60) member 1

multiple interactions

Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPD1 protein]

NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,526

G

interferon induced protein with tetratricopeptide repeats 3

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFIT1 mRNA]

NCBI chr14:101,237,403...101,249,486
Ensembl chr14:101,237,571...101,249,498

G

interferon beta 1

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNB1 mRNA]

NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495

G

interferon gamma

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of IFNG mRNA]

NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670

G

interleukin 12B

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL12B mRNA]

NCBI chr16:64,143,268...64,158,929
Ensembl chr16:64,143,268...64,158,929

G

interleukin 6

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL6 mRNA]

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

interferon regulatory factor 7

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of IRF7 mRNA]

NCBI chr 2:372,235...375,572
Ensembl chr 2:372,238...375,378

G

ISG15 ubiquitin like modifier

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of ISG15 mRNA]

NCBI chr 6:63,363,201...63,364,211
Ensembl chr 6:63,363,173...63,364,208

G

interleukin-1 beta-like

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of IL1B mRNA]

G

poly(ADP-ribose) polymerase 1

multiple interactions

Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein]

NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Chloroquine inhibits the reaction [SZU-101 results in increased expression of RELA protein]

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

sequestosome 1

multiple interactions
increases expression

Chloroquine inhibits the reaction [ochratoxin A results in decreased expression of SQSTM1 protein]
Chloroquine results in increased expression of SQSTM1 protein

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

toll like receptor 7

multiple interactions

Chloroquine affects the localization of and results in decreased activity of TLR7 protein

NCBI chr X:9,573,178...9,576,987

chlorotoluron

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 2 subfamily B member 6B

decreases response to substance

CYP2B6B protein results in decreased susceptibility to chlortoluron

NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334

G

cytochrome P450 2C49

decreases response to substance

CYP2C49 protein results in decreased susceptibility to chlortoluron

NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455

chlorpromazine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

D-amino acid oxidase

decreases activity

Chlorpromazine results in decreased activity of DAO protein

NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,931,541...41,950,633

G

flavin containing dimethylaniline monoxygenase 1

increases oxidation

FMO1 protein results in increased oxidation of Chlorpromazine

NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076

chlorpyrifos

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

increases expression

Chlorpyrifos results in increased expression of BAX mRNA

PMID:34399389 PMID:38565334

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

BCL2 apoptosis regulator

decreases expression

Chlorpyrifos results in decreased expression of BCL2 mRNA

PMID:34399389 PMID:38565334

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

caspase 3

increases cleavage
increases expression

Chlorpyrifos results in increased cleavage of CASP3 mRNA
Chlorpyrifos results in increased expression of CASP3 mRNA

PMID:34399389 PMID:38565334

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

catalase

decreases expression

Chlorpyrifos results in decreased expression of CAT mRNA

PMID:34399389 PMID:38565334

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

dishevelled associated activator of morphogenesis 1

decreases expression

Chlorpyrifos results in decreased expression of DAAM1 mRNA; Chlorpyrifos results in decreased expression of DAAM1 protein

NCBI chr 1:188,335,335...188,511,094
Ensembl chr 1:188,335,384...188,511,096

G

fascin actin-bundling protein 1

decreases expression

Chlorpyrifos results in decreased expression of FSCN1 mRNA; Chlorpyrifos results in decreased expression of FSCN1 protein

NCBI chr 3:4,134,173...4,143,275
Ensembl chr 3:4,134,177...4,143,286

G

gap junction protein alpha 1

increases expression

Chlorpyrifos results in increased expression of GJA1 mRNA; Chlorpyrifos results in increased expression of GJA1 protein

NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156

G

glutathione peroxidase 2

decreases expression

Chlorpyrifos results in decreased expression of GPX2 mRNA

PMID:34399389 PMID:38565334

NCBI chr 7:89,007,636...89,011,620
Ensembl chr 7:89,007,375...89,011,620

G

myosin X

decreases expression

Chlorpyrifos results in decreased expression of MYO10 mRNA; Chlorpyrifos results in decreased expression of MYO10 protein

NCBI chr16:5,907,111...6,145,485
Ensembl chr16:5,907,116...6,094,845

G

prostaglandin-endoperoxide synthase 2

decreases expression

Chlorpyrifos results in decreased expression of PTGS2 mRNA

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

hyaluronan synthase 2

decreases expression

Chlorpyrifos results in decreased expression of SHAS2 mRNA

NCBI chr 4:17,583,154...17,613,524
Ensembl chr 4:17,596,492...17,615,480

G

superoxide dismutase 1

decreases expression

Chlorpyrifos results in decreased expression of SOD1 mRNA

PMID:34399389 PMID:38565334

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

superoxide dismutase 2

decreases expression

Chlorpyrifos results in decreased expression of SOD2 mRNA

PMID:34399389 PMID:38565334

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

TNF alpha induced protein 6

decreases expression

Chlorpyrifos results in decreased expression of TNFAIP6 mRNA

NCBI chr15:862,013...881,352
Ensembl chr15:862,015...881,461

chlorpyrifos-methyl

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acylaminoacyl-peptide hydrolase

decreases activity

chlorpyrifos-methyl results in decreased activity of APEH protein

NCBI chr13:32,205,863...32,214,517
Ensembl chr13:32,205,609...32,214,518

chlortetracycline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier organic anion transporter family member 1A2

increases uptake
multiple interactions

SLCO1A2 protein results in increased uptake of Chlortetracycline
Chlortetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]; Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Chlortetracycline]

NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730

choline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

DNA methyltransferase 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA

NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844

G

DNA methyltransferase 3 alpha

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA

NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087

G

glutathione peroxidase 1

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glycogen synthase 1

multiple interactions

[Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter; [Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA; [Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter

NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261

G

lactate dehydrogenase A

multiple interactions

[bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter

NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715

G

methylenetetrahydrofolate reductase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA

NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820

G

sucrase-isomaltase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA

NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478

G

solute carrier family 15 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA

NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933

G

solute carrier family 5 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA

NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841

G

superoxide dismutase 1

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

chondroitin sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

fibroblast growth factor 10

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein

NCBI chr16:28,695,465...28,779,953
Ensembl chr16:28,695,470...28,777,509

G

fibroblast growth factor 18

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein

NCBI chr16:52,724,867...52,760,246
Ensembl chr16:52,725,356...52,759,791

G

fibroblast growth factor 2

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF2 protein

NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916

G

midkine

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein

NCBI chr 2:16,130,787...16,133,791
Ensembl chr 2:16,130,788...16,133,510

G

pleiotrophin

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to PTN protein

NCBI chr18:12,219,708...12,309,045
Ensembl chr18:12,219,787...12,309,044

cilastatin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

multiple interactions

Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 8

multiple interactions

Cilastatin inhibits the reaction [Cisplatin results in increased activity of CASP8 protein]

NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468

G

Fas ligand

multiple interactions

Cilastatin inhibits the reaction [Cisplatin affects the localization of FASLG protein]

NCBI chr 9:115,068,314...115,075,147
Ensembl chr 9:115,068,090...115,076,464

cinaciguat

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

guanylate cyclase 1 soluble subunit alpha 1

multiple interactions

BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1A1 protein]

NCBI chr 8:44,448,758...44,520,737
Ensembl chr 8:44,449,290...44,518,135

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

BAY 58-2667 inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein]

NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,687

clorgyline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

monoamine oxidase A

decreases activity

Clorgyline analog results in decreased activity of MAOA protein

NCBI chr X:38,930,452...39,006,220

cocaine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

endothelin 1

increases expression
multiple interactions

Cocaine results in increased expression of EDN1 protein
1,3-ditolylguanidine inhibits the reaction [Cocaine results in increased expression of EDN1 protein]; Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]

NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348

crizotinib

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

neurotrophic receptor tyrosine kinase 1

decreases activity

Crizotinib results in decreased activity of NTRK1 protein

NCBI chr 4:93,219,509...93,237,944
Ensembl chr 4:93,219,516...93,255,981

G

neurotrophic receptor tyrosine kinase 2

decreases activity

Crizotinib results in decreased activity of NTRK2 protein

NCBI chr10:30,030,050...30,429,938
Ensembl chr10:30,033,405...30,429,882

cyanocob(III)alamin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

DNA methyltransferase 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA

NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844

G

DNA methyltransferase 3 alpha

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA

NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087

G

glutathione peroxidase 1

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

methylenetetrahydrofolate reductase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA

NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820

G

sucrase-isomaltase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA

NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478

G

solute carrier family 15 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA

NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933

G

solute carrier family 5 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA

NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841

G

superoxide dismutase 1

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

cycloheximide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activating transcription factor 4

multiple interactions

Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of ATF4 protein]; Cycloheximide inhibits the reaction [Cadmium results in increased expression of ATF4 protein]

NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368

G

chloride intracellular channel 5

decreases expression
multiple interactions

Cycloheximide results in decreased expression of CLIC5 protein
Cycloheximide promotes the reaction [Cadmium Chloride results in decreased expression of CLIC5 protein]

NCBI chr 7:40,683,044...40,808,017
Ensembl chr 7:40,682,907...40,863,886

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Cycloheximide inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]; Cycloheximide inhibits the reaction [Cadmium results in increased expression of HSPA5 protein]

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

G

LDL receptor related protein 2

decreases expression
multiple interactions

Cycloheximide results in decreased expression of LRP2 protein
Cycloheximide promotes the reaction [Cadmium Chloride results in decreased expression of LRP2 protein]

NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,303...75,716,694

cyclophosphamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

Panobinostat inhibits the reaction [Cyclophosphamide results in increased expression of BAX mRNA]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

BCL2 apoptosis regulator

multiple interactions
decreases expression

Panobinostat inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 mRNA]

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

H2A.X variant histone

increases expression
multiple interactions

Cyclophosphamide results in increased expression of H2AX protein
Panobinostat inhibits the reaction [Cyclophosphamide results in increased expression of H2AX protein]

NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084

G

Nanog homeobox

multiple interactions

[Panobinostat co-treated with Cyclophosphamide] results in increased expression of NANOG mRNA

NCBI chr 5:62,931,642...62,939,086
Ensembl chr 5:62,932,382...62,939,082

G

POU class 5 homeobox 1

decreases expression
multiple interactions

Cyclophosphamide results in decreased expression of POU5F1 mRNA
Panobinostat inhibits the reaction [Cyclophosphamide results in decreased expression of POU5F1 mRNA]

NCBI chr 7:23,564,654...23,570,691

G

superoxide dismutase 1

multiple interactions
decreases expression

Panobinostat inhibits the reaction [Cyclophosphamide results in decreased expression of SOD1 mRNA]

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

SRY-box transcription factor 2

decreases expression
multiple interactions

Cyclophosphamide results in decreased expression of SOX2 mRNA
Panobinostat inhibits the reaction [Cyclophosphamide results in decreased expression of SOX2 mRNA]

NCBI chr13:119,668,476...119,669,435
Ensembl chr13:119,668,476...119,669,435

cyclosporin A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions
affects localization

Vitamin E inhibits the reaction [Cyclosporine affects the localization of BAX protein]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

caspase 6

multiple interactions
increases expression

Vitamin E inhibits the reaction [Cyclosporine results in increased expression of CASP6 mRNA]

NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,520,629...112,537,045

G

cytochrome c, somatic

multiple interactions
affects localization

Vitamin E inhibits the reaction [Cyclosporine affects the localization of CYCS protein]

NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866

G

endothelin 1

increases secretion

Cyclosporine results in increased secretion of EDN1 protein

NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348

G

FYVE, RhoGEF and PH domain containing 4

multiple interactions
increases expression

Vitamin E inhibits the reaction [Cyclosporine results in increased expression of DNM1L protein]

NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028

G

mitofusin 2

multiple interactions
decreases expression

Vitamin E inhibits the reaction [Cyclosporine results in decreased expression of MFN2 protein]

NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438

G

nitric oxide synthase 3

decreases expression

Cyclosporine results in decreased expression of NOS3 protein

NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943

G

OPA1 mitochondrial dynamin like GTPase

multiple interactions
decreases expression

Vitamin E inhibits the reaction [Cyclosporine results in decreased expression of OPA1 protein]

NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083

G

Rac family small GTPase 1

affects localization

Cyclosporine affects the localization of RAC1 protein

NCBI chr 3:4,781,776...4,803,510
Ensembl chr 3:4,781,780...4,803,543

G

solute carrier family 2 member 1

increases expression
decreases response to substance
multiple interactions

Cyclosporine results in increased expression of SLC2A1 mRNA; Cyclosporine results in increased expression of SLC2A1 protein
SLC2A1 protein results in decreased susceptibility to Cyclosporine
Amiloride promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA]; Phloretin promotes the reaction [Cyclosporine results in increased expression of SLC2A1 mRNA]; Phloretin promotes the reaction [Cyclosporine results in increased expression of SLC2A1 protein]

NCBI chr 6:168,535,398...168,561,170
Ensembl chr 6:168,535,440...168,560,867

cylindrospermopsin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

decreases uptake

cylindrospermopsin results in decreased uptake of ALB protein

NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696

G

ATPase Na+/K+ transporting subunit alpha 1

increases expression

cylindrospermopsin results in increased expression of ATP1A1 mRNA

NCBI chr 4:104,353,506...104,384,321
Ensembl chr 4:104,353,506...104,384,680

G

DAB adaptor protein 2

decreases expression

cylindrospermopsin results in decreased expression of DAB2 mRNA

NCBI chr16:24,590,638...24,776,937
Ensembl chr16:24,590,645...24,646,122

G

LDL receptor related protein 2

decreases expression

cylindrospermopsin results in decreased expression of LRP2 mRNA

NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,303...75,716,694

cysteamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

flavin containing dimethylaniline monoxygenase 1

increases metabolic processing

FMO1 protein results in increased metabolism of Cysteamine

NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076

dantrolene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ryanodine receptor 1

multiple interactions
decreases activity

5'-adenylyl (beta,gamma-methylene)diphosphonate affects the reaction [Dantrolene results in decreased activity of RYR1 protein]; [Dantrolene inhibits the reaction [Calcium results in increased activity of RYR1 protein]] which results in decreased secretion of Calcium; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein mutant form]; Dantrolene inhibits the reaction [Caffeine results in increased activity of RYR1 protein]; Dantrolene inhibits the reaction [Calcium results in increased activity of RYR1 protein]; Dantrolene inhibits the reaction [Ryanodine binds to RYR1 protein mutant form]; Dantrolene inhibits the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Strontium promotes the reaction [Ryanodine binds to RYR1 protein]]

NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458

dermatan sulfate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

fibroblast growth factor 10

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF10 protein

NCBI chr16:28,695,465...28,779,953
Ensembl chr16:28,695,470...28,777,509

G

fibroblast growth factor 18

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF18 protein

NCBI chr16:52,724,867...52,760,246
Ensembl chr16:52,725,356...52,759,791

G

fibroblast growth factor 2

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to FGF2 protein

NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916

G

midkine

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to MDK protein

NCBI chr 2:16,130,787...16,133,791
Ensembl chr 2:16,130,788...16,133,510

G

pleiotrophin

affects binding

[Chondroitin Sulfates binds to Dermatan Sulfate] which binds to PTN protein

NCBI chr18:12,219,708...12,309,045
Ensembl chr18:12,219,787...12,309,044

desferrioxamine B

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hypoxia inducible factor 1 subunit alpha

increases expression

Deferoxamine results in increased expression of HIF1A protein

PMID:11514583 PMID:15089098

NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845

diarsenic trioxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases expression

Arsenic Trioxide results in increased expression of CASP3

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

glutamate-cysteine ligase catalytic subunit

increases activity
increases expression

Arsenic Trioxide results in increased activity of GCLC protein
Arsenic Trioxide results in increased expression of GCLC mRNA

NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530

G

gamma-glutamyltransferase 1

increases activity
increases expression

Arsenic Trioxide results in increased activity of GGT1 protein
Arsenic Trioxide results in increased expression of GGT1 mRNA

NCBI chr14:49,618,737...49,638,054

G

tumor protein p53

increases expression

Arsenic Trioxide results in increased expression of TP53

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

diazinon

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

Diazinon results in decreased activity of ACHE protein

NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,441...8,738,605

dichlorvos

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity

Dichlorvos results in decreased activity of ACHE protein

NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,441...8,738,605

G

acylaminoacyl-peptide hydrolase

decreases activity

Dichlorvos results in decreased activity of APEH protein

NCBI chr13:32,205,863...32,214,517
Ensembl chr13:32,205,609...32,214,518

G

butyrylcholinesterase

decreases activity

Dichlorvos results in decreased activity of BCHE protein

NCBI chr13:104,946,732...105,007,568

diethyldithiocarbamic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

proopiomelanocortin

multiple interactions

Ditiocarb promotes the reaction [Sodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]]

NCBI chr 3:113,661,712...113,668,558
Ensembl chr 3:113,661,004...113,670,418

G

superoxide dismutase 1

decreases activity
multiple interactions

Ditiocarb results in decreased activity of SOD1 protein
SOD1 protein affects the susceptibility to [Ditiocarb co-treated with 6-anilino-5,8-quinolinedione]

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

diisopropyl fluorophosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acylaminoacyl-peptide hydrolase

decreases activity

Isoflurophate results in decreased activity of APEH protein

NCBI chr13:32,205,863...32,214,517
Ensembl chr13:32,205,609...32,214,518

G

butyrylcholinesterase

decreases activity

Isoflurophate results in decreased activity of BCHE protein

NCBI chr13:104,946,732...105,007,568

diquat

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

affects activity
decreases activity
multiple interactions
decreases expression

Diquat affects the activity of CAT protein
Diquat results in decreased activity of CAT protein
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Diquat results in decreased activity of CAT protein]; [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of CAT mRNA]

PMID:22558963 PMID:32280687 PMID:38567716

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

claudin 1

decreases expression

Diquat results in decreased expression of CLDN1 protein

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

claudin 3

decreases expression
multiple interactions

Diquat results in decreased expression of CLDN3 protein
Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN3 protein]

NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102

G

claudin 4

multiple interactions
decreases expression

Amino Acids inhibits the reaction [Diquat results in decreased expression of CLDN4 protein]

NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925

G

DNA damage inducible transcript 3

increases expression

Diquat results in increased expression of DDIT3 protein

NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829

G

eukaryotic translation initiation factor 2 alpha kinase 3

increases phosphorylation

Diquat results in increased phosphorylation of EIF2AK3 protein

NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

Diquat results in increased phosphorylation of EIF2S1 protein

NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827

G

glutathione peroxidase 1

multiple interactions
decreases expression

3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA]; [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA]

PMID:32280687 PMID:38567716

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione peroxidase 4

decreases expression
multiple interactions

Diquat results in decreased expression of GPX4 mRNA
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Diquat results in decreased expression of GPX4 mRNA]; Carbonyl Cyanide m-Chlorophenyl Hydrazone promotes the reaction [Diquat results in decreased expression of GPX4 mRNA]

NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931

G

heat shock protein family A (Hsp70) member 5

increases expression

Diquat results in increased expression of HSPA5 protein

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

G

interleukin-1 beta-like

multiple interactions
increases expression

[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in increased expression of IL1B mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in increased expression of IL1B mRNA]

G

NFE2 like bZIP transcription factor 2

multiple interactions
decreases expression

[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA]

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

occludin

increases expression

Diquat results in increased expression of OCLN protein

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

protein phosphatase 1 regulatory subunit 16A

increases activity

Diquat results in increased activity of GPT protein

NCBI chr 4:302,621...320,048
Ensembl chr 4:297,748...320,056

G

superoxide dismutase 1

multiple interactions
decreases expression

3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA]; [Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA]

PMID:32280687 PMID:38567716

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

tryptophan 2,3-dioxygenase

increases expression

Diquat results in increased expression of TDO2 mRNA

NCBI chr 8:44,708,722...44,725,954
Ensembl chr 8:44,708,746...44,740,962

G

tight junction protein 1

decreases expression

Diquat results in decreased expression of TJP1 protein

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

tight junction protein 2

decreases expression
multiple interactions

Diquat results in decreased expression of TJP2 protein
Amino Acids inhibits the reaction [Diquat results in decreased expression of TJP2 protein]

NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983

G

tight junction protein 3

decreases expression
multiple interactions

Diquat results in decreased expression of TJP3 protein
Amino Acids inhibits the reaction [Diquat results in decreased expression of TJP3 protein]

NCBI chr 2:74,938,153...74,971,431
Ensembl chr 2:74,938,152...74,971,531

G

tumor necrosis factor

multiple interactions
increases expression

[Zinc binds to alpha-hydroxy-gamma-methylmercaptobutyric acid] inhibits the reaction [Diquat results in increased expression of TNF mRNA]; Zinc Sulfate inhibits the reaction [Diquat results in increased expression of TNF mRNA]

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

dobutamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

hexokinase 2

decreases expression

Dobutamine results in decreased expression of HK2 protein

NCBI chr 3:68,155,656...68,231,187
Ensembl chr 3:68,153,835...68,231,615

G

nitric oxide synthase 2

affects response to substance

NOS2 protein affects the susceptibility to Dobutamine

NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146

G

glycogen phosphorylase, muscle associated

decreases expression

Dobutamine results in decreased expression of PYGM protein

NCBI chr 2:7,409,330...7,421,256
Ensembl chr 2:7,409,116...7,421,254

DPDPE

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

multiple interactions

Enkephalin, D-Penicillamine (2,5)- inhibits the reaction [AGT protein results in increased secretion of Aldosterone]

NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833

G

opioid receptor delta 1

multiple interactions

Enkephalin, D-Penicillamine (2,5)- inhibits the reaction [OPRD1 protein results in increased transport of Barium]

NCBI chr 6:85,775,576...85,827,170
Ensembl chr 6:85,785,276...85,830,877

ebselen

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATPase H+/K+ transporting subunit alpha

multiple interactions

ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein]

NCBI chr 6:44,984,014...45,057,796
Ensembl chr 6:44,984,233...44,997,552

G

ATPase H+/K+ transporting subunit beta

multiple interactions

ebselen results in decreased activity of [ATP4A protein binds to ATP4B protein]

NCBI chr11:78,780,013...78,785,143
Ensembl chr11:78,780,013...78,785,116

enalapril

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

affects activity

Enalapril affects the activity of AGT protein

NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833

enalaprilat dihydrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

decreases activity

Enalaprilat results in decreased activity of AGT protein modified form

NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833

G

kininogen 1

increases activity

Enalaprilat results in increased activity of KNG1 protein modified form

NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958

ethylenediaminetetraacetic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alanyl aminopeptidase, membrane

multiple interactions

Edetic Acid promotes the reaction [1,10-phenanthroline results in decreased activity of ANPEP protein]

NCBI chr 7:55,351,081...55,373,856
Ensembl chr 7:55,351,087...55,373,881

G

leukotriene A4 hydrolase

decreases activity

Edetic Acid results in decreased activity of LTA4H protein

NCBI chr 5:87,486,552...87,518,520
Ensembl chr 5:87,486,512...87,518,515

Evodiamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 1, apoptosis-related cysteine peptidase

increases expression
multiple interactions

evodiamine results in increased expression of CASP1 mRNA
2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [evodiamine inhibits the reaction [T-2 Toxin results in increased expression of CASP1 protein]]; evodiamine inhibits the reaction [T-2 Toxin results in increased expression of CASP1 mRNA]; evodiamine inhibits the reaction [T-2 Toxin results in increased expression of CASP1 protein]

NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328

G

catalase

increases activity
multiple interactions

evodiamine results in increased activity of CAT protein
evodiamine inhibits the reaction [T-2 Toxin results in decreased activity of CAT protein]

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

component of inhibitor of nuclear factor kappa B kinase complex

decreases expression
multiple interactions

evodiamine results in decreased expression of CHUK protein
evodiamine inhibits the reaction [T-2 Toxin results in increased expression of CHUK protein]

NCBI chr14:111,316,178...111,351,669
Ensembl chr14:111,315,141...111,351,868

G

claudin 1

multiple interactions

2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [evodiamine inhibits the reaction [T-2 Toxin results in decreased expression of CLDN1 protein]]; evodiamine inhibits the reaction [T-2 Toxin results in decreased expression of CLDN1 mRNA]; evodiamine inhibits the reaction [T-2 Toxin results in decreased expression of CLDN1 protein]

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

gasdermin D

multiple interactions

2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [evodiamine inhibits the reaction [T-2 Toxin results in increased expression of GSDMD protein]]; evodiamine inhibits the reaction [T-2 Toxin results in increased expression of GSDMD protein]

NCBI chr 4:995,753...1,001,964
Ensembl chr 4:995,763...1,000,271

G

interleukin 18

multiple interactions

evodiamine inhibits the reaction [T-2 Toxin results in increased expression of IL18 mRNA]; evodiamine inhibits the reaction [T-2 Toxin results in increased expression of IL18 protein]

NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219

G

kelch like ECH associated protein 1

multiple interactions
decreases expression

2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [evodiamine inhibits the reaction [T-2 Toxin results in decreased expression of KEAP1 protein]]; evodiamine inhibits the reaction [T-2 Toxin results in decreased expression of KEAP1 protein]
evodiamine results in decreased expression of KEAP1 protein

NCBI chr 2:69,280,940...69,290,267
Ensembl chr 2:69,276,336...69,294,382

G

interleukin-1 beta-like

decreases expression
multiple interactions

evodiamine results in decreased expression of IL1B mRNA
evodiamine inhibits the reaction [T-2 Toxin results in increased expression of IL1B mRNA]; evodiamine inhibits the reaction [T-2 Toxin results in increased expression of IL1B protein]

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide affects the reaction [evodiamine affects the reaction [T-2 Toxin affects the localization of NFE2L2 protein]]; evodiamine affects the reaction [T-2 Toxin affects the localization of NFE2L2 protein]; evodiamine inhibits the reaction [T-2 Toxin results in decreased expression of NFE2L2 mRNA]
evodiamine results in increased expression of NFE2L2 mRNA

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

NLR family pyrin domain containing 3

multiple interactions
increases expression

2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [evodiamine inhibits the reaction [T-2 Toxin results in increased expression of NLRP3 protein]]; evodiamine inhibits the reaction [T-2 Toxin results in increased expression of NLRP3 mRNA]; evodiamine inhibits the reaction [T-2 Toxin results in increased expression of NLRP3 protein]
evodiamine results in increased expression of NLRP3 mRNA

NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228

G

occludin

multiple interactions

2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [evodiamine inhibits the reaction [T-2 Toxin results in decreased expression of OCLN protein]]; evodiamine inhibits the reaction [T-2 Toxin results in decreased expression of OCLN mRNA]; evodiamine inhibits the reaction [T-2 Toxin results in decreased expression of OCLN protein]

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

PYD and CARD domain containing

multiple interactions

evodiamine inhibits the reaction [T-2 Toxin results in increased expression of PYCARD mRNA]; evodiamine inhibits the reaction [T-2 Toxin results in increased expression of PYCARD protein]

NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786

G

RELA proto-oncogene, NF-kB subunit

decreases phosphorylation
multiple interactions

evodiamine results in decreased phosphorylation of RELA protein
2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide affects the reaction [evodiamine affects the reaction [T-2 Toxin affects the localization of RELA protein]]; 2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [evodiamine inhibits the reaction [T-2 Toxin results in increased phosphorylation of RELA protein]]; evodiamine affects the reaction [T-2 Toxin affects the localization of RELA protein]; evodiamine inhibits the reaction [T-2 Toxin results in increased expression of RELA mRNA]; evodiamine inhibits the reaction [T-2 Toxin results in increased phosphorylation of RELA protein]

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

tight junction protein 1

multiple interactions

2-(1,3-benzodioxol-5-yl)-N-(5-methyl-4-(1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl)-1,3-thiazol-2-yl)acetamide inhibits the reaction [evodiamine inhibits the reaction [T-2 Toxin results in decreased expression of TJP1 protein]]; evodiamine inhibits the reaction [T-2 Toxin results in decreased expression of TJP1 mRNA]; evodiamine inhibits the reaction [T-2 Toxin results in decreased expression of TJP1 protein]

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

ezetimibe

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

3-hydroxy-3-methylglutaryl-CoA reductase

increases expression
multiple interactions

Ezetimibe results in increased expression of HMGCR mRNA
Simvastatin promotes the reaction [Ezetimibe results in increased expression of HMGCR mRNA]

NCBI chr 2:84,380,245...84,401,117
Ensembl chr 2:84,380,224...84,402,957

G

low density lipoprotein receptor

multiple interactions
increases expression

Simvastatin promotes the reaction [Ezetimibe results in increased expression of LDLR mRNA]

NCBI chr 2:69,828,348...69,864,823
Ensembl chr 2:69,828,332...69,864,827

G

NPC1 like intracellular cholesterol transporter 1

multiple interactions
increases expression

Simvastatin promotes the reaction [Ezetimibe results in increased expression of NPC1L1 mRNA]

NCBI chr18:50,726,854...50,757,676
Ensembl chr18:50,726,922...50,757,649

G

sterol regulatory element binding transcription factor 1

multiple interactions

[Ezetimibe co-treated with Simvastatin] results in increased expression of SREBF1 mRNA

NCBI chr12:60,733,967...60,750,951
Ensembl chr12:60,733,907...60,751,267

G

sterol regulatory element binding transcription factor 2

multiple interactions
increases expression

Simvastatin promotes the reaction [Ezetimibe results in increased expression of SREBF2 mRNA]

NCBI chr 5:6,719,484...6,784,724
Ensembl chr 5:6,719,490...6,784,671

fenbendazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B (MDR/TAP), member 1

affects expression

Fenbendazole affects the expression of ABCB1 mRNA

NCBI chr 9:93,049,955...93,146,469

G

cytochrome P450 family 1 subfamily A member 2

affects expression

Fenbendazole affects the expression of CYP1A2 mRNA

NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100

G

cytochrome P450 family 2 subfamily E member 1

affects expression

Fenbendazole affects the expression of CYP2E1 mRNA

NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817

G

cytochrome P450 family 3 subfamily A member 22

affects expression

Fenbendazole affects the expression of CYP3A22 mRNA

NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817

G

cytochrome P450 family 3 subfamily A member 29

affects expression

Fenbendazole affects the expression of CYP3A29 mRNA

NCBI chr 3:6,738,502...6,778,121
Ensembl chr 3:6,738,486...6,778,944

G

sulfotransferase family 1A member 3

affects expression

Fenbendazole affects the expression of SULT1A1 mRNA

NCBI chr 3:18,351,205...18,354,653
Ensembl chr 3:18,351,194...18,354,649

ferroheme b

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

heme oxygenase 1

increases metabolic processing
multiple interactions

HMOX1 protein results in increased metabolism of Heme
[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide; chromium mesoporphyrin inhibits the reaction [[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide]; tin protoporphyrin IX inhibits the reaction [[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide]

flunixin meglumine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP-binding cassette, sub-family B (MDR/TAP), member 1

affects expression

flunixin meglumine affects the expression of ABCB1 mRNA

NCBI chr 9:93,049,955...93,146,469

G

cytochrome P450 family 1 subfamily A member 2

affects expression

flunixin meglumine affects the expression of CYP1A2 mRNA

NCBI chr 7:58,779,529...58,786,155
Ensembl chr 7:58,779,475...58,786,100

G

cytochrome P450 family 2 subfamily E member 1

affects expression

flunixin meglumine affects the expression of CYP2E1 mRNA

NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817

G

cytochrome P450 family 3 subfamily A member 22

affects expression

flunixin meglumine affects the expression of CYP3A22 mRNA

NCBI chr 3:6,617,256...6,665,179
Ensembl chr 3:6,615,343...6,822,817

G

cytochrome P450 family 3 subfamily A member 29

affects expression

flunixin meglumine affects the expression of CYP3A29 mRNA

NCBI chr 3:6,738,502...6,778,121
Ensembl chr 3:6,738,486...6,778,944

G

sulfotransferase family 1A member 3

affects expression

flunixin meglumine affects the expression of SULT1A1 mRNA

NCBI chr 3:18,351,205...18,354,653
Ensembl chr 3:18,351,194...18,354,649

flutamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

gap junction protein alpha 1

affects expression

Flutamide affects the expression of GJA1 mRNA

NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156

folic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

cystathionine beta-synthase

multiple interactions
increases activity

[Ethanol co-treated with Folic Acid deficiency] results in increased activity of CBS protein
Folic Acid deficiency results in increased activity of CBS protein

NCBI chr13:206,205,942...206,231,363
Ensembl chr13:206,205,946...206,230,248

G

colony stimulating factor 2

multiple interactions

[Folic Acid co-treated with Glycine] results in decreased expression of CSF2 mRNA

NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155

G

cystathionine gamma-lyase

multiple interactions

[Ethanol co-treated with Folic Acid deficiency] results in increased activity of CTH protein

NCBI chr 6:142,454,922...142,486,352
Ensembl chr 6:142,454,914...142,486,367

G

DNA methyltransferase 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA

NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844

G

DNA methyltransferase 3 alpha

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA

NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087

G

glutamate-cysteine ligase catalytic subunit

multiple interactions

[Ethanol co-treated with Folic Acid deficiency] results in increased activity of GCLC protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GCLC mRNA

NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530

G

glutathione peroxidase 1

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione-disulfide reductase

increases activity
increases expression
multiple interactions

Folic Acid deficiency results in increased activity of GSR protein
Folic Acid deficiency results in increased expression of GSR mRNA
[Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSR protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSR mRNA

NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,984

G

glutathione synthetase

multiple interactions

[Ethanol co-treated with Folic Acid deficiency] results in increased activity of GSS protein; [Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSS mRNA

NCBI chr17:38,316,199...38,342,253
Ensembl chr17:38,312,720...38,342,298

G

glycogen synthase 1

multiple interactions

[Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter; [Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA; [Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter

NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261

G

lactate dehydrogenase A

multiple interactions

[bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter

NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715

G

glutathione S-transferase alpha M14

multiple interactions
increases expression

[Ethanol co-treated with Folic Acid deficiency] results in increased expression of GSTA1 mRNA
Folic Acid deficiency results in increased expression of GSTA1 mRNA

NCBI chr 7:46,553,813...46,567,596

G

methylenetetrahydrofolate reductase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA

NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820

G

prostaglandin-endoperoxide synthase 1

multiple interactions

[Folic Acid co-treated with Glycine] results in decreased expression of PTGS1

NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[Folic Acid co-treated with Glycine] results in increased expression of PTGS2

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

sucrase-isomaltase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA

NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478

G

solute carrier family 15 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA

NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933

G

solute carrier family 5 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA

NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841

G

superoxide dismutase 1

multiple interactions
decreases activity

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA; [Ethanol co-treated with Folic Acid deficiency] results in decreased activity of SOD1 protein
Folic Acid deficiency results in decreased activity of SOD1 protein

PMID:16792574 PMID:29129240

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

superoxide dismutase 2

increases activity
multiple interactions

Folic Acid deficiency results in increased activity of SOD2 protein; Folic Acid results in increased activity of SOD2 protein
[Ethanol co-treated with Folic Acid deficiency] results in increased activity of SOD2 protein

PMID:16792574 PMID:22889112

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

fumonisin B1

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

advanced glycosylation end-product specific receptor

increases expression

fumonisin B1 results in increased expression of AGER mRNA

NCBI chr 7:24,218,116...24,221,162
Ensembl chr 7:24,218,120...24,221,162

G

apoptotic peptidase activating factor 1

increases expression
multiple interactions

fumonisin B1 results in increased expression of APAF1 mRNA; fumonisin B1 results in increased expression of APAF1 protein
fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of APAF1 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of APAF1 protein]

NCBI chr 5:85,166,616...85,258,751
Ensembl chr 5:85,166,628...85,258,364

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

fumonisin B1 results in increased expression of BAX mRNA; fumonisin B1 results in increased expression of BAX protein
[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX protein]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of BAX mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of BAX protein]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of BAX mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA]; Resveratrol inhibits the reaction [fumonisin B1 results in increased expression of BAX protein]

PMID:33905761 PMID:36397609 PMID:37955343

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

BCL2 apoptosis regulator

decreases expression
multiple interactions

fumonisin B1 results in decreased expression of BCL2 mRNA; fumonisin B1 results in decreased expression of BCL2 protein
[Acetylcysteine co-treated with fumonisin B1 co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of BCL2 protein; [fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 protein; [fumonisin B1 co-treated with Zearalenone co-treated with deoxynivalenol] results in decreased expression of BCL2 protein; [fumonisin B1 co-treated with Zearalenone] results in decreased expression of BCL2 mRNA; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]]; fumonisin B1 inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; fumonisin B1 inhibits the reaction [Zearalenone inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 mRNA]]; fumonisin B1 promotes the reaction [ochratoxin A results in decreased expression of BCL2 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in decreased expression of BCL2 protein]; fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in decreased expression of BCL2 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA]; Zearalenone inhibits the reaction [fumonisin B1 inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]]; Zearalenone inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]]

PMID:29109043 PMID:33905761 PMID:36397609

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

caspase 1, apoptosis-related cysteine peptidase

multiple interactions

N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP1 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP1 protein]

NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328

G

caspase 10

multiple interactions
increases expression

3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of CASP10 mRNA]

NCBI chr15:104,858,082...104,895,941
Ensembl chr15:104,858,100...104,894,933

G

caspase 3

increases cleavage
increases expression
multiple interactions

fumonisin B1 results in increased cleavage of CASP3 protein
fumonisin B1 results in increased expression of CASP3 mRNA; fumonisin B1 results in increased expression of CASP3 protein; fumonisin B1 results in increased expression of CASP3 protein modified form
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of CASP3 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of CASP3 protein]; [fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA; [fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 protein; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form; [fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]; [fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA; [fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]]; deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]; fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CASP3 mRNA]]; fumonisin B1 promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP3 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP3 protein modified form]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP3 protein]; fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP3 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP3 protein modified form]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein]; Resveratrol inhibits the reaction [fumonisin B1 results in increased cleavage of CASP3 protein]; Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]

PMID:29109043 PMID:32198028 PMID:33905761 PMID:36397609 PMID:37955343

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 8

multiple interactions
increases expression

3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of CASP8 mRNA]

NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468

G

caspase 9

multiple interactions
increases expression

[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP9 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP9 protein modified form]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP9 protein]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP9 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP9 protein modified form]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP9 protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein]
fumonisin B1 results in increased expression of CASP9 mRNA; fumonisin B1 results in increased expression of CASP9 protein; fumonisin B1 results in increased expression of CASP9 protein modified form

PMID:33905761 PMID:36397609

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

chemokine (C-C motif) ligand 2

multiple interactions
decreases expression
increases expression

[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of CCL2 mRNA; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL2 mRNA]
fumonisin B1 results in decreased expression of CCL2 mRNA
fumonisin B1 metabolite results in increased expression of CCL2 mRNA; fumonisin B1 results in increased expression of CCL2 mRNA

PMID:23688591 PMID:30708112

NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026

G

C-C motif chemokine ligand 20

multiple interactions
increases expression

fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CCL20 mRNA]
fumonisin B1 results in increased expression of CCL20 mRNA

NCBI chr15:129,172,743...129,176,069

G

component of inhibitor of nuclear factor kappa B kinase complex

increases expression

fumonisin B1 results in increased expression of CHUK mRNA

NCBI chr14:111,316,178...111,351,669
Ensembl chr14:111,315,141...111,351,868

G

claudin 1

decreases expression
multiple interactions

fumonisin B1 results in decreased expression of CLDN1 mRNA; fumonisin B1 results in decreased expression of CLDN1 protein
Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of CLDN1 mRNA]; Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of CLDN1 protein]

PMID:31557363 PMID:37955343

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

C-X-C motif chemokine ligand 8

increases expression
multiple interactions

fumonisin B1 results in increased expression of CXCL8 mRNA
[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of CXCL8 mRNA; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CXCL8 mRNA]; fumonisin B1 promotes the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of CXCL8 mRNA]

PMID:23688591 PMID:30708112

NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861

G

cytochrome c, somatic

multiple interactions

[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]; fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CYCS mRNA]; Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA]

PMID:29109043 PMID:36397609

NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866

G

FYVE, RhoGEF and PH domain containing 4

multiple interactions
increases expression

3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in increased expression of DNM1L mRNA]

NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028

G

gasdermin D

multiple interactions

belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of GSDMD protein]

NCBI chr 4:995,753...1,001,964
Ensembl chr 4:995,763...1,000,271

G

glutathione-disulfide reductase

multiple interactions

Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]; fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]

NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,984

G

hepatitis A virus cellular receptor 1

multiple interactions

[fumonisin B1 co-treated with ochratoxin A] results in increased expression of HAVCR1 mRNA

NCBI chr16:66,162,318...66,208,868

G

interferon gamma

decreases expression

fumonisin B1 metabolite results in decreased expression of IFNG protein

NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670

G

interleukin 17A

multiple interactions

fumonisin B1 inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of IL17A protein]; fumonisin B1 metabolite inhibits the reaction [[deoxynivalenol co-treated with Lipopolysaccharides] results in increased expression of IL17A protein]

NCBI chr 7:46,013,584...46,017,161
Ensembl chr 7:46,013,584...46,017,153

G

interleukin 18

multiple interactions

belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL18 protein]

NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219

G

interleukin 1 alpha

increases expression
decreases expression
multiple interactions

fumonisin B1 results in increased expression of IL1A mRNA
fumonisin B1 results in decreased expression of IL1A mRNA
[deoxynivalenol co-treated with fumonisin B1] results in decreased expression of IL1A mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of IL1A mRNA

NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,121

G

interleukin 6

increases expression
multiple interactions
decreases expression

fumonisin B1 results in increased expression of IL6 mRNA
[deoxynivalenol co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [nivalenol co-treated with fumonisin B1] results in decreased expression of IL6 mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of IL6 mRNA; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA]; Resveratrol inhibits the reaction [fumonisin B1 results in increased expression of IL6 mRNA]
fumonisin B1 results in decreased expression of IL6 mRNA

PMID:23688591 PMID:30708112 PMID:37955343 PMID:38705344

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

lipocalin 2

multiple interactions
increases expression

[fumonisin B1 co-treated with ochratoxin A] results in increased expression of LCN2 mRNA; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of LCN2 mRNA]

PMID:33905761 PMID:38705344

NCBI chr 1:268,609,975...268,614,651
Ensembl chr 1:268,609,887...268,614,644

G

interleukin-1 beta-like

increases expression
multiple interactions

fumonisin B1 results in increased expression of IL1B mRNA
[deoxynivalenol co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of IL1B mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of IL1B mRNA; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B mRNA]; belnacasan inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of IL1B protein]; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA]; Resveratrol inhibits the reaction [fumonisin B1 results in increased expression of IL1B mRNA]

PMID:23688591 PMID:36309173 PMID:37955343 PMID:38705344

G

microtubule associated protein 1 light chain 3 beta

increases expression
multiple interactions

fumonisin B1 results in increased expression of MAP1LC3B mRNA
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in increased expression of MAP1LC3B mRNA]; fumonisin B1 results in increased lipidation of and results in increased localization of MAP1LC3B protein

NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069

G

mitogen-activated protein kinase kinase kinase 14

increases expression

fumonisin B1 results in increased expression of MAP3K14 mRNA

NCBI chr12:18,142,899...18,182,931
Ensembl chr12:18,142,952...18,182,928

G

mitogen-activated protein kinase 1

increases phosphorylation

fumonisin B1 results in increased phosphorylation of MAPK1 protein

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 10

multiple interactions
increases expression

3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of MAPK10 mRNA]

NCBI chr 8:132,445,818...132,751,575
Ensembl chr 8:132,298,299...132,776,820

G

mitogen-activated protein kinase 3

increases phosphorylation

fumonisin B1 results in increased phosphorylation of MAPK3 protein

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

mitogen-activated protein kinase 8

increases expression
multiple interactions

fumonisin B1 results in increased expression of MAPK8 mRNA; fumonisin B1 results in increased expression of MAPK8 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of MAPK8 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of MAPK8 protein]

NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874

G

mitogen-activated protein kinase 9

increases expression
multiple interactions

fumonisin B1 results in increased expression of MAPK9 mRNA
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of MAPK9 mRNA]

NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100

G

mitofusin 2

increases expression

fumonisin B1 results in increased expression of MFN2 mRNA

NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438

G

mixed lineage kinase domain like pseudokinase

increases expression
multiple interactions

fumonisin B1 results in increased expression of MLKL mRNA; fumonisin B1 results in increased expression of MLKL protein
necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of MLKL mRNA]; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of MLKL protein]

NCBI chr 6:12,923,846...12,951,176
Ensembl chr 6:12,924,894...12,951,173

G

mucin 1, cell surface associated

decreases expression

fumonisin B1 results in decreased expression of MUC1 mRNA

NCBI chr 4:94,626,317...94,631,194

G

mucin 2, oligomeric mucus/gel-forming

increases expression

fumonisin B1 results in increased expression of MUC2 mRNA

NCBI chr 2:689,363...719,542
Ensembl chr 2:689,364...710,330

G

NFE2 like bZIP transcription factor 1

multiple interactions
decreases expression

3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in decreased expression of NFE2L1 mRNA]

NCBI chr12:24,303,381...24,316,765
Ensembl chr12:24,303,399...24,316,763

G

NFE2 like bZIP transcription factor 2

decreases expression
multiple interactions

fumonisin B1 results in decreased expression of NFE2L2 protein
Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of NFE2L2 protein]

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

nuclear factor kappa B subunit 1

increases expression
multiple interactions

fumonisin B1 results in increased expression of NFKB1 mRNA; fumonisin B1 results in increased expression of NFKB1 protein
3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of NFKB1 mRNA]; 3-(4-methylphenylsulfonyl)-2-propenenitrile inhibits the reaction [fumonisin B1 results in increased expression of NFKB1 protein]

NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691

G

NAD(P)H quinone dehydrogenase 1

decreases expression
multiple interactions

fumonisin B1 results in decreased expression of NQO1 mRNA; fumonisin B1 results in decreased expression of NQO1 protein
Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of NQO1 mRNA]; Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of NQO1 protein]

NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590

G

netrin 1

multiple interactions
increases expression

fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of NTN1 mRNA]; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of NTN1 mRNA]

PMID:33905761 PMID:38705344

NCBI chr12:54,089,444...54,292,191
Ensembl chr12:54,089,472...54,292,193

G

occludin

decreases expression
multiple interactions

fumonisin B1 results in decreased expression of OCLN mRNA; fumonisin B1 results in decreased expression of OCLN protein
Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of OCLN mRNA]; Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of OCLN protein]

PMID:31557363 PMID:37955343

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

OPA1 mitochondrial dynamin like GTPase

increases expression

fumonisin B1 results in increased expression of OPA1 mRNA

NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083

G

PTEN induced kinase 1

multiple interactions
increases expression

3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in increased expression of PINK1 mRNA]; 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in increased expression of PINK1 protein]
fumonisin B1 results in increased expression of PINK1 mRNA; fumonisin B1 results in increased expression of PINK1 protein

NCBI chr 6:78,863,195...78,884,663
Ensembl chr 6:78,863,190...78,884,640

G

PPARG coactivator 1 alpha

decreases expression
multiple interactions

fumonisin B1 results in decreased expression of PPARGC1A mRNA
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in decreased expression of PPARGC1A mRNA]

NCBI chr 8:17,841,844...18,527,953
Ensembl chr 8:17,841,844...17,946,992

G

parkin RBR E3 ubiquitin protein ligase

increases expression
multiple interactions

fumonisin B1 results in increased expression of PRKN mRNA; fumonisin B1 results in increased expression of PRKN protein
3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in increased expression of PRKN mRNA]; 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in increased expression of PRKN protein]

NCBI chr 1:5,698,508...6,731,132
Ensembl chr 1:5,465,312...6,730,872

G

receptor interacting serine/threonine kinase 1

multiple interactions
increases expression

necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of RIPK1 mRNA]; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of RIPK1 protein]
fumonisin B1 results in increased expression of RIPK1 mRNA; fumonisin B1 results in increased expression of RIPK1 protein

NCBI chr 7:1,841,143...1,880,705
Ensembl chr 7:1,841,239...1,880,699

G

receptor interacting serine/threonine kinase 3

multiple interactions
increases expression

necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of RIPK3 mRNA]; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of RIPK3 protein]
fumonisin B1 results in increased expression of RIPK3 mRNA; fumonisin B1 results in increased expression of RIPK3 protein

NCBI chr 7:74,951,145...74,955,255
Ensembl chr 7:74,951,145...74,955,251

G

solute carrier family 15 member 1

increases expression

fumonisin B1 results in increased expression of SLC15A1 mRNA

NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933

G

solute carrier family 1 member 1

decreases expression

fumonisin B1 results in decreased expression of SLC1A1 mRNA

NCBI chr 1:217,366,493...217,441,643
Ensembl chr 1:217,366,499...217,441,674

G

solute carrier family 27 member 4

decreases expression

fumonisin B1 results in decreased expression of SLC27A4 mRNA

NCBI chr 1:268,773,792...268,788,208
Ensembl chr 1:268,773,806...268,788,731

G

solute carrier family 2 member 2

decreases expression

fumonisin B1 results in decreased expression of SLC2A2 mRNA

NCBI chr13:109,592,595...109,614,105
Ensembl chr13:109,587,258...109,638,510

G

solute carrier family 7 member 1

decreases expression

fumonisin B1 results in decreased expression of SLC7A1 mRNA

NCBI chr11:6,538,053...6,604,654
Ensembl chr11:6,538,045...6,604,658

G

solute carrier family 7 member 7

decreases expression

fumonisin B1 results in decreased expression of SLC7A7 mRNA

NCBI chr 7:76,195,774...76,235,406
Ensembl chr 7:76,198,256...76,235,402

G

superoxide dismutase 1

multiple interactions
decreases expression

Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of SOD1 mRNA]; Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of SOD1 protein]
fumonisin B1 results in decreased expression of SOD1 mRNA; fumonisin B1 results in decreased expression of SOD1 protein

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

secreted phosphoprotein 1

increases expression
multiple interactions

fumonisin B1 results in increased expression of SPP1 mRNA
fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of SPP1 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of SPP1 mRNA]

NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340

G

sequestosome 1

multiple interactions
increases expression

3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in decreased expression of SQSTM1 mRNA]; 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in decreased expression of SQSTM1 protein]; 3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in increased lipidation of and results in increased localization of SQSTM1 protein]
fumonisin B1 results in increased expression of SQSTM1 mRNA; fumonisin B1 results in increased expression of SQSTM1 protein

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

transcription factor A, mitochondrial

multiple interactions
decreases expression

3-(2,4-dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone inhibits the reaction [fumonisin B1 results in decreased expression of TFAM mRNA]

NCBI chr14:92,261,713...92,279,731
Ensembl chr14:92,259,403...92,279,731

G

tight junction protein 1

decreases expression
multiple interactions

fumonisin B1 results in decreased expression of TJP1 mRNA; fumonisin B1 results in decreased expression of TJP1 protein
Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of TJP1 mRNA]; Resveratrol inhibits the reaction [fumonisin B1 results in decreased expression of TJP1 protein]

PMID:31557363 PMID:37955343

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

tumor necrosis factor

multiple interactions
increases expression

[deoxynivalenol co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with Lipopolysaccharides co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with Lipopolysaccharides co-treated with fumonisin B1] results in increased expression of TNF protein; [deoxynivalenol co-treated with nivalenol co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of TNF mRNA; [deoxynivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of TNF mRNA; [nivalenol co-treated with fumonisin B1] results in increased expression of TNF mRNA; [nivalenol co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of TNF mRNA; [Zearalenone co-treated with fumonisin B1] results in increased expression of TNF mRNA; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of TNF mRNA]; necrostatin-1 inhibits the reaction [fumonisin B1 results in increased expression of TNF protein]; Resveratrol inhibits the reaction [fumonisin B1 results in increased expression of TNF mRNA]
fumonisin B1 results in increased expression of TNF mRNA; fumonisin B1 results in increased expression of TNF protein

PMID:23688591 PMID:30708112 PMID:32198028 PMID:37955343 PMID:38705344

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

G

tumor protein p53

increases expression
multiple interactions

fumonisin B1 results in increased expression of TP53 mRNA
[deoxynivalenol co-treated with fumonisin B1] results in increased expression of TP53 mRNA; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in increased expression of TP53 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 results in increased expression of TP53 mRNA]]; fumonisin B1 inhibits the reaction [deoxynivalenol inhibits the reaction [Zearalenone results in increased expression of TP53 mRNA]]; fumonisin B1 promotes the reaction [Zearalenone results in increased expression of TP53 mRNA]; Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of TP53 mRNA]; Zearalenone promotes the reaction [fumonisin B1 results in increased expression of TP53 mRNA]

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

TNFRSF1A associated via death domain

increases expression

fumonisin B1 results in increased expression of TRADD mRNA

NCBI chr 6:27,797,594...27,804,654
Ensembl chr 6:27,797,607...27,804,423

G

TNF receptor associated factor 2

increases expression

fumonisin B1 results in increased expression of TRAF2 mRNA

gabapentin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calcium voltage-gated channel auxiliary subunit alpha2delta 1

affects binding

Gabapentin binds to CACNA2D1 protein

NCBI chr 9:97,781,057...98,265,925
Ensembl chr 9:97,781,090...98,266,969

gefitinib

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

FES proto-oncogene, tyrosine kinase

multiple interactions
decreases phosphorylation

Gefitinib inhibits the reaction [FGF2 protein results in increased phosphorylation of FES protein]; Gefitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of FES protein]
Gefitinib results in decreased phosphorylation of FES protein

NCBI chr 7:53,472,947...53,485,084
Ensembl chr 7:53,472,947...53,485,082

G

fibroblast growth factor 2

multiple interactions

Gefitinib inhibits the reaction [FGF2 protein results in increased phosphorylation of FES protein]

NCBI chr 8:101,278,877...101,344,084
Ensembl chr 8:101,278,885...101,343,916

G

vascular endothelial growth factor A

multiple interactions

Gefitinib inhibits the reaction [VEGFA protein results in increased phosphorylation of FES protein]

NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366

glutathione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amine oxidase copper containing 1

multiple interactions

Glutathione inhibits the reaction [Paraquat results in increased expression of AOC1 protein]

NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974

G

cytochrome P450 family 2 subfamily B member 6B

multiple interactions

[Glutathione co-treated with Paraquat] results in decreased expression of CYP2B6B mRNA

NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334

G

cytochrome P450 3A39

multiple interactions

Glutathione inhibits the reaction [Paraquat results in increased expression of CYP3A39 mRNA]

G

DnaJ heat shock protein family (Hsp40) member C7

multiple interactions

[Glutathione co-treated with Paraquat] results in increased expression of DNAJC7 mRNA

NCBI chr12:20,725,937...20,756,295
Ensembl chr12:20,725,975...20,759,000

G

fatty acid binding protein 2

multiple interactions

Glutathione inhibits the reaction [Paraquat results in increased activity of FABP2 protein]

NCBI chr 8:104,464,342...104,468,059
Ensembl chr 8:104,464,342...104,470,480

G

glutamate-cysteine ligase modifier subunit

multiple interactions

[Glutathione co-treated with Paraquat] results in increased expression of GCLM mRNA

NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131

G

glutathione peroxidase 4

multiple interactions

[Glutathione co-treated with Paraquat] results in increased expression of GPX4 mRNA

NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931

G

heat shock protein 90 alpha family class A member 1

multiple interactions

[Glutathione co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA

G

isocitrate dehydrogenase (NADP(+)) 2

multiple interactions

Glutathione inhibits the reaction [Cadmium Chloride results in decreased activity of IDH2 protein]; Glutathione inhibits the reaction [Cadmium results in decreased activity of IDH2 protein]

NCBI chr 7:55,654,298...55,675,571
Ensembl chr 7:55,651,609...55,675,554

G

interferon gamma

multiple interactions

Glutathione inhibits the reaction [Paraquat results in increased expression of IFNG mRNA]

NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670

G

interleukin 10

multiple interactions

[Glutathione co-treated with Paraquat] results in increased expression of IL10 mRNA

NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378

G

glutathione S-transferase P-like

multiple interactions

GSTP1 protein affects the metabolism of [monobromobimane co-treated with Glutathione]

NCBI chr 2:5,005,498...5,009,247

G

glutathione S-transferase alpha M14

multiple interactions

[Glutathione co-treated with Paraquat] results in increased expression of GSTA2 mRNA; Glutathione inhibits the reaction [Paraquat results in decreased expression of GSTA1 mRNA]

NCBI chr 7:46,553,813...46,567,596

G

nuclear receptor subfamily 1 group I member 3

multiple interactions

Glutathione inhibits the reaction [Paraquat results in increased expression of NR1I3 mRNA]

NCBI chr 4:89,226,314...89,231,781
Ensembl chr 4:89,226,690...89,236,431

G

occludin

multiple interactions

Glutathione inhibits the reaction [Paraquat results in decreased expression of OCLN protein]

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

superoxide dismutase 2

multiple interactions

[Glutathione co-treated with Paraquat] affects the expression of SOD2 mRNA

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

tight junction protein 1

multiple interactions

Glutathione inhibits the reaction [Paraquat results in decreased expression of TJP1 protein]

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

glyburide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

endothelin 1

multiple interactions

Glyburide inhibits the reaction [Carvedilol results in decreased expression of EDN1 protein]

NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348

glycerol 2-phosphate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alkaline phosphatase, biomineralization associated

multiple interactions

[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ALPL mRNA; bisphenol A diglycidyl ether promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of ALPL mRNA]

NCBI chr 6:79,589,695...79,649,646
Ensembl chr 6:79,589,045...79,649,644

G

BCL2 like 1

multiple interactions

[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of BCL2L1 mRNA

NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694

G

caspase 3

multiple interactions

[Troglitazone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CASP3 mRNA

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

CCAAT enhancer binding protein alpha

multiple interactions

[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CEBPA mRNA; Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CEBPA mRNA]

NCBI chr 6:43,083,200...43,085,884
Ensembl chr 6:43,083,207...43,085,836

G

collagen type I alpha 1 chain

multiple interactions

[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL1A1 mRNA; bisphenol A diglycidyl ether promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of COL1A1 mRNA]

NCBI chr12:26,379,087...26,397,180
Ensembl chr12:26,379,090...26,397,004

G

catenin beta 1

multiple interactions

[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CTNNB1 mRNA; bisphenol A diglycidyl ether promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CTNNB1 mRNA]; Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CTNNB1 mRNA]

NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311

G

fatty acid binding protein 4

multiple interactions

[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of FABP4 mRNA; bisphenol A diglycidyl ether inhibits the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of FABP4 mRNA]; Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of FABP4 mRNA]

NCBI chr 4:55,096,400...55,101,209
Ensembl chr 4:55,096,404...55,101,896

G

insulin like growth factor 1

multiple interactions

[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of IGF1 mRNA; Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of IGF1 mRNA]

NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033

G

insulin like growth factor 1 receptor

multiple interactions

[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of IGF1R mRNA; Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of IGF1R mRNA]

NCBI chr 1:137,383,623...137,691,038
Ensembl chr 1:137,387,825...137,691,058

G

peroxisome proliferator activated receptor gamma

multiple interactions

[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of PPARG mRNA; bisphenol A diglycidyl ether inhibits the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of PPARG mRNA]; Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of PPARG mRNA]

NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944

G

RUNX family transcription factor 2

multiple interactions

[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of RUNX2 mRNA; bisphenol A diglycidyl ether promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of RUNX2 mRNA]

NCBI chr 7:40,106,581...40,353,304
Ensembl chr 7:40,106,532...40,460,687

G

secreted phosphoprotein 1

multiple interactions

[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SPP1 mRNA; bisphenol A diglycidyl ether promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SPP1 mRNA]; Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SPP1 mRNA]

NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340

glycine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

apoptosis inducing factor mitochondria associated 1

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in increased expression of AIFM1 mRNA]

NCBI chr X:106,676,596...106,708,290
Ensembl chr X:106,670,520...106,708,317

G

anti-silencing function 1A histone chaperone

increases expression

Glycine results in increased expression of ASF1A mRNA

NCBI chr 1:43,200,339...43,215,019
Ensembl chr 1:43,200,415...43,214,913

G

anti-silencing function 1B histone chaperone

increases expression

Glycine results in increased expression of ASF1B mRNA

NCBI chr 2:65,063,186...65,072,681
Ensembl chr 2:65,062,766...65,072,679

G

BCL2 associated X, apoptosis regulator

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in increased expression of BAX mRNA]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

caspase 3

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in increased expression of and results in increased activity of CASP3 protein]; Glycine inhibits the reaction [monobutyl phthalate results in increased expression of CASP3 mRNA]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

catalase

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of CAT mRNA]

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

cell division cycle 26

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of CDC26 mRNA]

NCBI chr 1:253,893,666...253,906,659
Ensembl chr 1:253,895,885...253,906,632

G

colony stimulating factor 2

multiple interactions

[Folic Acid co-treated with Glycine] results in decreased expression of CSF2 mRNA

NCBI chr 2:134,354,724...134,357,155
Ensembl chr 2:134,354,724...134,357,155

G

DNA methyltransferase 1

increases expression
multiple interactions

Glycine results in increased expression of DNMT1 mRNA
Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of DNMT1 mRNA]

NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844

G

DNA methyltransferase 3 alpha

increases expression

Glycine results in increased expression of DNMT3A mRNA

NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087

G

H2A.X variant histone

decreases expression
multiple interactions

Glycine results in decreased expression of H2AX protein
Glycine inhibits the reaction [monobutyl phthalate results in increased expression of H2AX protein]

NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084

G

mitofusin 1

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of MFN1 mRNA]; Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of MFN1 protein]

NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481

G

mitofusin 2

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of MFN2 mRNA]; Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of MFN2 protein]

NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438

G

POU class 5 homeobox 1

multiple interactions

Glycine promotes the reaction [monobutyl phthalate results in decreased expression of POU5F1 mRNA]

NCBI chr 7:23,564,654...23,570,691

G

prostaglandin-endoperoxide synthase 1

multiple interactions

[Folic Acid co-treated with Glycine] results in decreased expression of PTGS1

NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035

G

prostaglandin-endoperoxide synthase 2

multiple interactions

[Folic Acid co-treated with Glycine] results in increased expression of PTGS2

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

SET domain containing 2, histone lysine methyltransferase

multiple interactions
increases expression

Glycine inhibits the reaction [monobutyl phthalate results in decreased expression of SETD2 protein]
Glycine results in increased expression of SETD2 protein

NCBI chr13:29,884,708...29,996,285
Ensembl chr13:29,884,719...29,996,359

G

tubulin alpha 1b

multiple interactions

Glycine inhibits the reaction [monobutyl phthalate results in increased expression of TUBA1B mRNA]

NCBI chr 5:15,150,229...15,153,620
Ensembl chr 5:15,149,099...15,153,620

glycine betaine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activating transcription factor 4

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of ATF4 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of ATF4 protein]

NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368

G

activating transcription factor 6

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of ATF6 mRNA]

NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304

G

BCL2 associated X, apoptosis regulator

multiple interactions

[Betaine co-treated with Glyphosate] results in increased expression of BAX mRNA

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

caspase 3

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of CASP3 mRNA]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 9

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of CASP9 mRNA]

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

catalase

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] promotes the reaction [bisphenol A results in decreased expression of CAT protein]; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT mRNA; [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of CAT protein; Betaine inhibits the reaction [Glyphosate results in increased expression of CAT mRNA]

PMID:29129240 PMID:36584959

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

claudin 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in decreased expression of CLDN1 mRNA]; Betaine inhibits the reaction [Glyphosate results in decreased expression of CLDN1 protein]

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

DNA damage inducible transcript 3

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of DDIT3 mRNA]

NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829

G

DNA methyltransferase 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT1 mRNA

NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844

G

DNA methyltransferase 3 alpha

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of DNMT3A mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of DNMT3A mRNA

NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2AK3 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2AK3 protein]

NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2S1 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2S1 protein]

NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of ERN1 mRNA]

NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284

G

glutathione peroxidase 1

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of GPX1 mRNA; [bisphenol A co-treated with [Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12]] results in increased expression of GPX1 mRNA

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione peroxidase 2

multiple interactions

[Betaine co-treated with Glyphosate] results in increased expression of GPX2 mRNA

NCBI chr 7:89,007,636...89,011,620
Ensembl chr 7:89,007,375...89,011,620

G

glycogen synthase 1

multiple interactions

[Betaine co-treated with Choline co-treated with Folic Acid co-treated with bisphenol A] results in increased methylation of GYS1 promoter; [Betaine co-treated with Choline co-treated with Folic Acid] results in decreased expression of GYS1 mRNA; [Betaine co-treated with Choline co-treated with Folic Acid] results in increased methylation of GYS1 promoter

NCBI chr 6:54,234,600...54,250,211
Ensembl chr 6:54,233,050...54,250,261

G

heat shock protein 90 beta family member 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of HSP90B1 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of HSP90B1 protein]

NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991

G

lactate dehydrogenase A

multiple interactions

[bisphenol A co-treated with Choline co-treated with Folic Acid co-treated with Betaine] results in decreased methylation of LDHA promoter

NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715

G

mitofusin 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of MFN1 mRNA]

NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481

G

methylenetetrahydrofolate reductase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of MTHFR mRNA

NCBI chr 6:71,863,637...71,882,118
Ensembl chr 6:71,863,637...71,881,820

G

NFE2 like bZIP transcription factor 2

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of NFE2L2 mRNA]

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

NAD(P)H quinone dehydrogenase 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of NQO1 mRNA]

NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590

G

proliferating cell nuclear antigen

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of PCNA mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of PCNA protein]

NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744

G

succinate dehydrogenase complex flavoprotein subunit A

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of SDHA mRNA]

NCBI chr16:79,838,442...79,862,956
Ensembl chr16:79,834,044...79,862,524

G

sucrase-isomaltase

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SI mRNA

NCBI chr13:104,296,281...104,379,558
Ensembl chr13:104,296,283...104,379,478

G

solute carrier family 15 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased expression of SLC15A1 mRNA]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] inhibits the reaction [bisphenol A results in decreased methylation of SLC15A1 promoter]; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC15A1 mRNA

NCBI chr11:67,652,808...67,690,457
Ensembl chr11:67,652,193...67,710,933

G

solute carrier family 5 member 1

multiple interactions

[Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid co-treated with bisphenol A] results in increased expression of SLC5A1 mRNA; [Betaine co-treated with Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SLC5A1 mRNA

NCBI chr14:48,566,400...48,704,145
Ensembl chr14:48,628,224...48,705,841

G

superoxide dismutase 1

multiple interactions

[Betaine co-treated with Folic Acid co-treated with Choline co-treated with Vitamin B 12] results in increased expression of SOD1 mRNA

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

superoxide dismutase 2

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of SOD2 mRNA]

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

ubiquinol-cytochrome c reductase binding protein

multiple interactions

[Betaine co-treated with Glyphosate] results in decreased expression of UQCRB mRNA

NCBI chr 4:40,403,272...40,409,080
Ensembl chr 4:40,403,109...40,409,057

G

X-box binding protein 1

multiple interactions

Betaine inhibits the reaction [Glyphosate results in increased expression of XBP1 mRNA]

NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526

glyphosate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activating transcription factor 4

increases expression
multiple interactions

Glyphosate results in increased expression of ATF4 mRNA; Glyphosate results in increased expression of ATF4 protein
Betaine inhibits the reaction [Glyphosate results in increased expression of ATF4 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of ATF4 protein]

NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368

G

activating transcription factor 6

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of ATF6 mRNA]

NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304

G

BCL2 associated X, apoptosis regulator

multiple interactions
increases expression

[Betaine co-treated with Glyphosate] results in increased expression of BAX mRNA
Glyphosate results in increased expression of BAX mRNA

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

caspase 3

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of CASP3 mRNA]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 9

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of CASP9 mRNA]

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

catalase

increases expression
multiple interactions
increases activity

Glyphosate results in increased expression of CAT mRNA
Betaine inhibits the reaction [Glyphosate results in increased expression of CAT mRNA]
Glyphosate results in increased activity of CAT protein

PMID:31677563 PMID:36584959

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

claudin 1

multiple interactions
decreases expression

Betaine inhibits the reaction [Glyphosate results in decreased expression of CLDN1 mRNA]; Betaine inhibits the reaction [Glyphosate results in decreased expression of CLDN1 protein]
Glyphosate results in decreased expression of CLDN1 mRNA; Glyphosate results in decreased expression of CLDN1 protein

PMID:31677563 PMID:36584959

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

C-X-C motif chemokine ligand 8

increases expression
multiple interactions

Glyphosate results in increased expression of CXCL8 mRNA
pyrrolidine dithiocarbamic acid inhibits the reaction [Glyphosate results in increased expression of CXCL8 mRNA]

NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861

G

DNA damage inducible transcript 3

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of DDIT3 mRNA]

NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2AK3 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2AK3 protein]
Glyphosate results in increased expression of EIF2AK3 mRNA; Glyphosate results in increased expression of EIF2AK3 protein

NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245

G

eukaryotic translation initiation factor 2 subunit alpha

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2S1 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of EIF2S1 protein]
Glyphosate results in increased expression of EIF2S1 mRNA; Glyphosate results in increased expression of EIF2S1 protein

NCBI chr 7:91,085,025...91,109,835
Ensembl chr 7:91,085,335...91,109,827

G

endoplasmic reticulum to nucleus signaling 1

increases expression
multiple interactions

Glyphosate results in increased expression of ERN1 mRNA
Betaine inhibits the reaction [Glyphosate results in increased expression of ERN1 mRNA]

NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284

G

glutamate-cysteine ligase modifier subunit

decreases expression

Glyphosate results in decreased expression of GCLM mRNA

PMID:31677563 PMID:35388968

NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131

G

glutathione peroxidase 1

decreases expression
decreases activity

Glyphosate results in decreased expression of GPX1 mRNA
Glyphosate results in decreased activity of GPX1 protein

PMID:31677563 PMID:35388968

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione peroxidase 2

multiple interactions

[Betaine co-treated with Glyphosate] results in increased expression of GPX2 mRNA

NCBI chr 7:89,007,636...89,011,620
Ensembl chr 7:89,007,375...89,011,620

G

glutathione S-transferase omega 1

increases expression

Glyphosate results in increased expression of GSTO1 mRNA

NCBI chr14:115,206,434...115,216,624
Ensembl chr14:115,206,188...115,216,613

G

heme oxygenase 1

decreases expression
multiple interactions
increases expression

Glyphosate results in decreased expression of HMOX1 mRNA
Glyphosate results in increased expression of and affects the localization of HMOX1 protein
Glyphosate results in increased expression of HMOX1 mRNA

PMID:31677563 PMID:35388968 PMID:36584959

G

heat shock protein 90 beta family member 1

increases expression
multiple interactions

Glyphosate results in increased expression of HSP90B1 mRNA; Glyphosate results in increased expression of HSP90B1 protein
Betaine inhibits the reaction [Glyphosate results in increased expression of HSP90B1 mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of HSP90B1 protein]

NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991

G

interleukin 10

increases expression

Glyphosate results in increased expression of IL10 protein

NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378

G

interleukin 6

increases expression
multiple interactions
affects secretion

Glyphosate results in increased expression of IL6 mRNA; Glyphosate results in increased expression of IL6 protein
pyrrolidine dithiocarbamic acid inhibits the reaction [Glyphosate results in increased expression of IL6 mRNA]
Glyphosate affects the secretion of IL6 protein

PMID:31677563 PMID:35388968 PMID:36584959

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

kelch like ECH associated protein 1

decreases expression

Glyphosate results in decreased expression of KEAP1 mRNA

NCBI chr 2:69,280,940...69,290,267
Ensembl chr 2:69,276,336...69,294,382

G

interleukin-1 beta-like

increases expression
multiple interactions
increases secretion

Glyphosate results in increased expression of IL1B mRNA; Glyphosate results in increased expression of IL1B protein
pyrrolidine dithiocarbamic acid inhibits the reaction [Glyphosate results in increased expression of IL1B mRNA]
Glyphosate results in increased secretion of IL1B protein

PMID:35388968 PMID:36584959

G

mitofusin 1

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of MFN1 mRNA]

NCBI chr13:117,404,637...117,441,750
Ensembl chr13:117,404,699...117,442,481

G

NFE2 like bZIP transcription factor 2

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of NFE2L2 mRNA]; Glyphosate results in increased expression of and affects the localization of NFE2L2 protein
Glyphosate results in increased expression of NFE2L2 mRNA; Glyphosate results in increased expression of NFE2L2 protein

PMID:31677563 PMID:35388968 PMID:36584959

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

nuclear factor kappa B subunit 1

increases expression

Glyphosate results in increased expression of NFKB1 mRNA

PMID:31677563 PMID:35388968

NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691

G

NFKB inhibitor alpha

multiple interactions

Glyphosate results in decreased expression of and results in increased phosphorylation of NFKBIA protein

NCBI chr 7:64,508,119...64,510,754
Ensembl chr 7:64,507,822...64,511,277

G

nitric oxide synthase 2

increases expression

Glyphosate results in increased expression of NOS2 mRNA

NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146

G

NAD(P)H quinone dehydrogenase 1

increases expression
multiple interactions

Glyphosate results in increased expression of NQO1 mRNA
Betaine inhibits the reaction [Glyphosate results in increased expression of NQO1 mRNA]

PMID:31677563 PMID:35388968 PMID:36584959

NCBI chr 6:17,292,962...17,302,593
Ensembl chr 6:17,292,770...17,302,590

G

proliferating cell nuclear antigen

increases expression
multiple interactions

Glyphosate results in increased expression of PCNA mRNA; Glyphosate results in increased expression of PCNA protein
Betaine inhibits the reaction [Glyphosate results in increased expression of PCNA mRNA]; Betaine inhibits the reaction [Glyphosate results in increased expression of PCNA protein]

NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744

G

RELA proto-oncogene, NF-kB subunit

increases phosphorylation

Glyphosate results in increased phosphorylation of RELA protein

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

succinate dehydrogenase complex flavoprotein subunit A

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of SDHA mRNA]

NCBI chr16:79,838,442...79,862,956
Ensembl chr16:79,834,044...79,862,524

G

superoxide dismutase 1

decreases activity

Glyphosate results in decreased activity of SOD1 protein

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

superoxide dismutase 2

increases expression
multiple interactions

Glyphosate results in increased expression of SOD2 mRNA
Betaine inhibits the reaction [Glyphosate results in increased expression of SOD2 mRNA]

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

sequestosome 1

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [Glyphosate results in decreased expression of SQSTM1 protein]

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

tight junction protein 1

decreases expression

Glyphosate results in decreased expression of TJP1 mRNA

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

tumor necrosis factor

affects secretion
increases expression

Glyphosate affects the secretion of TNF protein
Glyphosate results in increased expression of TNF protein

PMID:35388968 PMID:36584959

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

G

ubiquinol-cytochrome c reductase binding protein

multiple interactions

[Betaine co-treated with Glyphosate] results in decreased expression of UQCRB mRNA

NCBI chr 4:40,403,272...40,409,080
Ensembl chr 4:40,403,109...40,409,057

G

X-box binding protein 1

multiple interactions
increases expression

Betaine inhibits the reaction [Glyphosate results in increased expression of XBP1 mRNA]

NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526

GSK2656157

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activating transcription factor 4

multiple interactions

GSK2656157 inhibits the reaction [deoxynivalenol results in increased expression of ATF4 protein]

NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368

G

DNA damage inducible transcript 3

multiple interactions

GSK2656157 inhibits the reaction [deoxynivalenol results in increased expression of DDIT3 protein]

NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829

G

eukaryotic translation initiation factor 2A

multiple interactions

GSK2656157 inhibits the reaction [deoxynivalenol results in increased phosphorylation of EIF2A protein]

NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,274

G

eukaryotic translation initiation factor 2 alpha kinase 3

multiple interactions

GSK2656157 inhibits the reaction [deoxynivalenol results in increased phosphorylation of EIF2AK3 protein]

NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,943...57,506,245

haloperidol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

endothelin 1

multiple interactions

Haloperidol inhibits the reaction [Cocaine results in increased expression of EDN1 protein]

NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348

heme b

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

heme oxygenase 1

multiple interactions
increases metabolic processing

[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide; chromium mesoporphyrin inhibits the reaction [[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide]; tin protoporphyrin IX inhibits the reaction [[HMOX1 protein results in increased metabolism of Heme] which results in increased abundance of Carbon Monoxide]

heparin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

porcine seminal protein I

multiple interactions

zinc chloride promotes the reaction [PSP-I protein binds to Heparin]; Zinc promotes the reaction [PSP-I protein binds to Heparin]

NCBI chr14:132,302,376...132,309,388
Ensembl chr14:132,302,352...132,308,106

himbacine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor muscarinic 4

multiple interactions

himbacine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein]

NCBI chr 2:16,119,794...16,131,080
Ensembl chr 2:16,122,704...16,130,810

histamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

histamine receptor H2

multiple interactions

[Histamine affects the activity of HRH2 protein] which affects the secretion of Chlorides

NCBI chr 2:81,883,670...81,932,464
Ensembl chr 2:81,883,673...81,932,275

hyaluronic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

epidermal growth factor receptor

multiple interactions

EGFR protein affects the chemical synthesis of and affects the localization of Hyaluronic Acid

NCBI chr 9:139,302,410...139,474,632
Ensembl chr 9:139,300,022...139,475,589

hypoxanthine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catalase

multiple interactions

CAT protein inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; CAT protein results in decreased activity of [Hypoxanthine co-treated with XDH protein]

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

xanthine dehydrogenase

multiple interactions

[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide; [Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Hydrogen Peroxide; [Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Superoxides; CAT protein inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; CAT protein results in decreased activity of [Hypoxanthine co-treated with XDH protein]; tempol inhibits the reaction [[Hypoxanthine co-treated with XDH protein] results in increased chemical synthesis of Carbon Monoxide]; tempol results in decreased activity of [Hypoxanthine co-treated with XDH protein]

NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,987,126...108,053,169

icatibant

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

kininogen 1

decreases activity

icatibant results in decreased activity of KNG1 protein modified form

NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958

imipramine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

flavin containing dimethylaniline monoxygenase 1

increases oxidation

FMO1 protein results in increased oxidation of Imipramine

NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076

indometacin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

affects activity

Indomethacin affects the activity of AGT protein

NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833

G

DNA damage inducible transcript 3

increases expression

Indomethacin results in increased expression of DDIT3 mRNA

NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829

G

heat shock protein family A (Hsp70) member 5

increases expression

Indomethacin results in increased expression of HSPA5 mRNA

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

isoxaben

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 2C49

decreases response to substance

CYP2C49 protein results in decreased susceptibility to isoxaben

NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455

itraconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

multiple interactions

Itraconazole inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines]

NCBI chr 9:93,171,371...93,262,124

ketoconazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 3 subfamily A member 29

multiple interactions

Ketoconazole inhibits the reaction [CYP3A29 protein results in increased chemical synthesis of 6 beta-hydroxytestosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased hydroxylation of Testosterone]; Ketoconazole inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine]

NCBI chr 3:6,738,502...6,778,121
Ensembl chr 3:6,738,486...6,778,944

KT 5823

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

collagen type IV alpha 2 chain

multiple interactions
decreases expression

KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A2 protein]
KT 5823 results in decreased expression of COL4A2 protein

NCBI chr11:76,996,885...77,161,617
Ensembl chr11:76,997,516...77,161,614

G

collagen type IV alpha 3 chain

decreases expression
multiple interactions

KT 5823 results in decreased expression of COL4A3 mRNA
KT 5823 inhibits the reaction [NOC 18 results in increased expression of COL4A3 mRNA]

NCBI chr15:128,611,640...128,763,331
Ensembl chr15:128,611,866...128,763,122

G

integrin subunit alpha V

multiple interactions

KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]]

NCBI chr15:91,604,666...91,711,843
Ensembl chr15:91,604,676...91,711,851

G

integrin subunit beta 3

multiple interactions

KT 5823 inhibits the reaction [NOC 18 results in increased expression of [ITGAV protein binds to ITGB3 protein]]

NCBI chr12:16,694,466...16,752,228
Ensembl chr12:16,693,514...16,752,292

L-cysteine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

albumin

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in decreased expression of ALB protein]

NCBI chr 8:69,643,427...69,663,152
Ensembl chr 8:69,531,487...69,721,696

G

claudin 1

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in decreased expression of CLDN1 mRNA]

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

glutamate-cysteine ligase catalytic subunit

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in increased expression of GCLC mRNA]

NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530

G

glutamate-cysteine ligase modifier subunit

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in increased expression of GCLM mRNA]

NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131

G

heme oxygenase 1

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in decreased expression of HMOX1 mRNA]

G

kelch like ECH associated protein 1

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in increased expression of KEAP1 mRNA]

NCBI chr 2:69,280,940...69,290,267
Ensembl chr 2:69,276,336...69,294,382

G

NADPH oxidase 1

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in decreased expression of NOX1 mRNA]

NCBI chr X:82,540,664...82,575,811
Ensembl chr X:82,540,667...82,586,532

G

protein phosphatase 1 regulatory subunit 16A

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in increased activity of GPT protein]

NCBI chr 4:302,621...320,048
Ensembl chr 4:297,748...320,056

G

succinate dehydrogenase complex flavoprotein subunit A

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in decreased expression of SDHA mRNA]

NCBI chr16:79,838,442...79,862,956
Ensembl chr16:79,834,044...79,862,524

G

superoxide dismutase 2

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in decreased expression of SOD2 mRNA]

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

tight junction protein 2

multiple interactions

Cysteine inhibits the reaction [bisphenol A results in decreased expression of TJP2 mRNA]

NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983

L-glutamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 10

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in decreased secretion of IL10 protein]

NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378

G

interleukin 6

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in increased expression of IL6 mRNA]; Glutamine inhibits the reaction [bisphenol A results in increased secretion of IL6 protein]

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

interleukin-1 beta-like

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in increased secretion of IL1B protein]

G

MYD88 innate immune signal transduction adaptor

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in increased expression of MYD88 mRNA]

NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109

G

nuclear factor kappa B subunit 1

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in increased expression of NFKB1 mRNA]

NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in increased expression of RELA protein]

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

trefoil factor 3

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in decreased expression of TFF3 protein]

NCBI chr13:205,641,038...205,644,333
Ensembl chr13:205,641,038...205,644,333

G

toll like receptor 4

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in increased expression of TLR4 mRNA]; Glutamine inhibits the reaction [bisphenol A results in increased expression of TLR4 protein]

NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970

G

tumor necrosis factor

multiple interactions

Glutamine inhibits the reaction [bisphenol A results in increased expression of TNF mRNA]; Glutamine inhibits the reaction [bisphenol A results in increased secretion of TNF protein]

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

lapatinib

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

follicle stimulating hormone subunit beta

multiple interactions
decreases activity

Lapatinib inhibits the reaction [FSHB protein results in increased abundance of Progesterone]
Lapatinib results in decreased activity of FSHB protein

NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274

G

luteinizing hormone subunit beta

decreases activity
multiple interactions

Lapatinib results in decreased activity of LHB protein
Lapatinib inhibits the reaction [LHB protein results in increased abundance of Progesterone]

NCBI chr 6:54,263,574...54,269,286
Ensembl chr 6:54,263,576...54,271,086

linsidomine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

DNA damage inducible transcript 3

increases expression

linsidomine results in increased expression of DDIT3 mRNA

NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression

linsidomine results in increased expression of FOS mRNA

NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554

G

heat shock protein family A (Hsp70) member 5

increases expression

linsidomine results in increased expression of HSPA5 mRNA

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

losartan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

affects activity

Losartan affects the activity of AGT protein

NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833

LY294002

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [etoxazole affects the phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]

PMID:16239170 PMID:31744678

G

chemokine (C-C motif) ligand 2

multiple interactions
decreases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCL2 mRNA

NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026

G

mitogen-activated protein kinase 1

multiple interactions

[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with etoxazole] results in increased phosphorylation of MAPK1 protein

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 3

multiple interactions

[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with etoxazole] results in increased phosphorylation of MAPK3 protein

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

mitogen-activated protein kinase 8

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [etoxazole results in increased phosphorylation of MAPK8 protein]

NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874

G

nitric oxide synthase 3

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of NOS3 protein]

NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943

G

ribosomal protein S6

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [etoxazole affects the phosphorylation of RPS6 protein]

NCBI chr 1:203,444,360...203,447,643
Ensembl chr 1:203,444,450...203,451,468

G

ribosomal protein S6 kinase B1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [etoxazole affects the phosphorylation of RPS6KB1 protein]

NCBI chr12:36,111,584...36,159,287
Ensembl chr12:36,111,653...36,160,376

G

vascular cell adhesion molecule 1

multiple interactions

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]

NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222

malathion

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 2

increases expression

Malathion results in increased expression of AKT2 mRNA

NCBI chr 6:48,555,785...48,620,472
Ensembl chr 6:48,555,795...48,587,919

G

BCL2 associated X, apoptosis regulator

increases expression

Malathion results in increased expression of BAX mRNA

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

BCL2 apoptosis regulator

multiple interactions
decreases expression

Melatonin inhibits the reaction [Malathion results in decreased expression of BCL2 mRNA]

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

catalase

decreases expression
multiple interactions

Malathion results in decreased expression of CAT mRNA
Melatonin inhibits the reaction [Malathion results in decreased expression of CAT mRNA]

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

cytochrome P450 family 1 subfamily A member 1

decreases expression

Malathion results in decreased expression of CYP1A1 mRNA

NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775

G

cytochrome P450 family 1 subfamily B member 1

decreases expression

Malathion results in decreased expression of CYP1B1 mRNA

NCBI chr 3:102,195,743...102,205,687
Ensembl chr 3:102,195,741...102,205,683

G

dual oxidase 2

decreases expression

Malathion results in decreased expression of DUOX2 mRNA

NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,510...126,641,406

G

glutathione peroxidase 4

increases expression

Malathion results in increased expression of GPX4 mRNA

NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931

G

glutathione peroxidase 6

increases expression

Malathion results in increased expression of GPX6 mRNA

NCBI chr 7:22,256,013...22,267,992
Ensembl chr 7:22,256,038...22,267,992

G

glutathione S-transferase alpha M14

decreases expression

Malathion results in decreased expression of GSTA1 mRNA

NCBI chr 7:46,553,813...46,567,596

G

mitochondrially encoded cytochrome c oxidase I

affects expression

Malathion affects the expression of COX1 mRNA

NCBI chr MT:6,511...8,055
Ensembl chr MT:6,511...8,055

G

mitochondrially encoded cytochrome c oxidase III

affects expression

Malathion affects the expression of COX3 mRNA

NCBI chr MT:9,800...10,583
Ensembl chr MT:9,800...10,583

G

perilipin 2

multiple interactions
decreases expression

Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 protein]
Malathion results in decreased expression of PLIN2 mRNA; Malathion results in decreased expression of PLIN2 protein

NCBI chr 1:203,683,867...203,709,277
Ensembl chr 1:203,683,862...203,709,273

G

peroxisome proliferator activated receptor gamma

decreases expression
multiple interactions

Malathion results in decreased expression of PPARG mRNA; Malathion results in decreased expression of PPARG protein
Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG protein]

NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944

G

solute carrier family 34 member 2

increases expression

Malathion results in increased expression of SLC34A2 mRNA

NCBI chr 8:19,481,127...19,507,903
Ensembl chr 8:19,481,198...19,509,666

G

superoxide dismutase 2

increases expression

Malathion results in increased expression of SOD2 mRNA

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

sorbitol dehydrogenase

increases expression

Malathion results in increased expression of SORD mRNA

NCBI chr 1:126,659,198...126,701,084
Ensembl chr 1:126,655,156...126,701,138

G

tumor protein p53

multiple interactions
increases expression

Melatonin inhibits the reaction [Malathion results in increased expression of TP53 mRNA]

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

mastoparan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

selectin E

increases expression

mastoparan results in increased expression of SELE mRNA

NCBI chr 4:81,289,061...81,299,657

melamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cadherin 2

decreases expression

melamine results in decreased expression of CDH2 protein

NCBI chr 6:112,396,713...112,629,073
Ensembl chr 6:112,396,721...112,628,432

G

gap junction protein alpha 1

decreases expression

melamine results in decreased expression of GJA1 protein

NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156

G

mitogen-activated protein kinase 1

increases phosphorylation

melamine results in increased phosphorylation of MAPK1 protein

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 3

increases phosphorylation

melamine results in increased phosphorylation of MAPK3 protein

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

occludin

decreases expression

melamine results in decreased expression of OCLN protein

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

tight junction protein 1

decreases expression

melamine results in decreased expression of TJP1 protein

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

melatonin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

allograft inflammatory factor 1

decreases expression
multiple interactions

Melatonin results in decreased expression of AIF1 mRNA
[Melatonin co-treated with bisphenol A co-treated with Resveratrol] results in increased expression of AIF1 mRNA; [Melatonin co-treated with bisphenol A] results in increased expression of AIF1 mRNA

NCBI chr 7:23,711,752...23,731,191
Ensembl chr 7:23,728,726...23,731,675

G

AKT serine/threonine kinase 1

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in decreased phosphorylation of AKT1 protein]

G

ARB2 cotranscriptional regulator A

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of ARB2A mRNA]

NCBI chr 2:100,477,770...100,893,594
Ensembl chr 2:100,477,775...100,893,580

G

autophagy related 5

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in increased expression of ATG5 protein]

NCBI chr 1:72,343,950...72,520,402
Ensembl chr 1:72,270,799...72,520,396

G

BCL2 associated X, apoptosis regulator

multiple interactions

Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of BAX mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of BAX protein]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

BCL2 apoptosis regulator

multiple interactions
increases expression

Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; Melatonin inhibits the reaction [Malathion results in decreased expression of BCL2 mRNA]
Melatonin results in increased expression of BCL2 mRNA

PMID:31535366 PMID:37120089 PMID:38848930

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

beclin 1

increases expression
multiple interactions

Melatonin results in increased expression of BECN1 protein
Melatonin inhibits the reaction [deoxynivalenol results in increased expression of BECN1 protein]

NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373

G

caspase 3

decreases expression
multiple interactions

Melatonin results in decreased expression of CASP3 mRNA
Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP3 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP3 protein]

PMID:31535366 PMID:35665993 PMID:38848930

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 8

multiple interactions

Melatonin inhibits the reaction [tetrabromobisphenol A results in decreased expression of CASP8 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in decreased expression of CASP8 protein]

NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468

G

caspase 9

multiple interactions

Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP9 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of CASP9 protein]

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

catalase

multiple interactions
increases activity
increases expression

Melatonin inhibits the reaction [deoxynivalenol results in decreased activity of CAT protein]; Melatonin inhibits the reaction [Malathion results in decreased expression of CAT mRNA]
Melatonin results in increased activity of CAT protein
Melatonin results in increased expression of CAT mRNA

PMID:31535366 PMID:37120089 PMID:38848930

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

caudal type homeobox 2

multiple interactions

[Melatonin co-treated with bisphenol A co-treated with Resveratrol] results in decreased expression of CDX2 protein; [Melatonin co-treated with bisphenol A] results in decreased expression of CDX2 protein

NCBI chr11:5,339,727...5,346,081
Ensembl chr11:5,339,716...5,346,057

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of CHUK mRNA]

NCBI chr14:111,316,178...111,351,669
Ensembl chr14:111,315,141...111,351,868

G

claudin 1

multiple interactions
increases expression

Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of CLDN1 protein]
Melatonin results in increased expression of CLDN1 protein

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

cytochrome c oxidase subunit 7A1

decreases expression

Melatonin results in decreased expression of COX7A1 mRNA

NCBI chr 6:45,519,225...45,520,721
Ensembl chr 6:45,517,229...45,520,713

G

cytochrome c oxidase subunit 7A2 like

multiple interactions

Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of COX7A2L mRNA]

NCBI chr 3:97,951,115...97,983,309
Ensembl chr 3:97,951,114...97,983,309

G

cytochrome P450 family 11 subfamily A member 1

increases expression

Melatonin results in increased expression of CYP11A1 mRNA

NCBI chr 7:59,172,829...59,188,479
Ensembl chr 7:59,175,758...59,188,478

G

cytochrome P450 19A3

increases expression

Melatonin results in increased expression of CYP19A3 mRNA

NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899

G

fibronectin 1

multiple interactions

[Melatonin co-treated with bisphenol A] results in decreased expression of FN1 protein

NCBI chr15:117,658,158...117,737,145
Ensembl chr15:117,658,099...117,731,043

G

glutathione peroxidase 1

increases expression
multiple interactions

Melatonin results in increased expression of GPX1 mRNA
[Melatonin co-treated with bisphenol A] results in decreased expression of GPX1 mRNA

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione peroxidase 4

increases expression

Melatonin results in increased expression of GPX4 mRNA

NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931

G

hydroxysteroid 17-beta dehydrogenase 2

increases expression

Melatonin results in increased expression of HSD17B2 mRNA

NCBI chr 6:6,296,429...6,360,434
Ensembl chr 6:6,292,707...6,360,633

G

interleukin 18

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in increased expression of IL18 mRNA]

NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219

G

interleukin 6

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in increased expression of IL6 protein]

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

KLF transcription factor 5

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of KLF5 mRNA]

NCBI chr11:45,370,009...45,386,673
Ensembl chr11:45,369,810...45,388,314

G

interleukin-1 beta-like

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in increased expression of IL1B protein]

G

microtubule associated protein 1 light chain 3 beta

multiple interactions

Melatonin affects the reaction [deoxynivalenol results in increased expression of and results in increased lipidation of MAP1LC3B protein]

NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069

G

mitogen-activated protein kinase kinase 1

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of MAP2K1 mRNA]

NCBI chr 1:164,381,892...164,469,313
Ensembl chr 1:164,381,845...164,471,226

G

microRNA mir-100

decreases expression
multiple interactions

Melatonin results in decreased expression of MIR100 mRNA
[Melatonin co-treated with bisphenol A co-treated with Resveratrol] results in increased expression of MIR100 mRNA; [Melatonin co-treated with bisphenol A] results in increased expression of MIR100 mRNA; Melatonin results in decreased expression of and results in decreased phosphorylation of MIR100 protein

NCBI chr 9:49,157,909...49,157,988
Ensembl chr 9:49,157,909...49,157,988

G

microRNA mir-155

multiple interactions

[Melatonin co-treated with bisphenol A] results in increased expression of MIR155 mRNA

NCBI chr13:189,138,822...189,138,902
Ensembl chr13:189,138,822...189,138,902

G

microRNA mir-21

increases expression
multiple interactions

Melatonin results in increased expression of MIR21 mRNA
[Melatonin co-treated with bisphenol A co-treated with Resveratrol] results in decreased expression of MIR21 mRNA; [Melatonin co-treated with bisphenol A] results in decreased expression of MIR21 mRNA

NCBI chr12:36,065,267...36,065,358
Ensembl chr12:36,065,267...36,065,358

G

mixed lineage kinase domain like pseudokinase

multiple interactions

Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of MLKL mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of MLKL protein]

NCBI chr 6:12,923,846...12,951,176
Ensembl chr 6:12,924,894...12,951,173

G

mechanistic target of rapamycin kinase

multiple interactions
decreases phosphorylation

Melatonin inhibits the reaction [deoxynivalenol results in decreased phosphorylation of MTOR protein]
Melatonin results in decreased phosphorylation of MTOR protein

NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888

G

mucin 1, cell surface associated

increases expression
multiple interactions

Melatonin results in increased expression of MUC1 protein
[Melatonin co-treated with bisphenol A co-treated with Resveratrol] results in decreased expression of MUC1 protein; [Melatonin co-treated with bisphenol A] results in decreased expression of MUC1 mRNA; [Melatonin co-treated with bisphenol A] results in decreased expression of MUC1 protein

NCBI chr 4:94,626,317...94,631,194

G

occludin

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of OCLN protein]

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

perilipin 2

multiple interactions

Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PLIN2 protein]

NCBI chr 1:203,683,867...203,709,277
Ensembl chr 1:203,683,862...203,709,273

G

peroxisome proliferator activated receptor gamma

multiple interactions

Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG mRNA]; Melatonin inhibits the reaction [Malathion results in decreased expression of PPARG protein]

NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944

G

phosphatase and tensin homolog

multiple interactions

Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of PTEN mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of PTEN protein]

NCBI chr14:99,929,590...100,021,619

G

receptor interacting serine/threonine kinase 1

multiple interactions

Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK1 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK1 protein]

NCBI chr 7:1,841,143...1,880,705
Ensembl chr 7:1,841,239...1,880,699

G

receptor interacting serine/threonine kinase 3

multiple interactions

Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK3 mRNA]; Melatonin inhibits the reaction [tetrabromobisphenol A results in increased expression of RIPK3 protein]

NCBI chr 7:74,951,145...74,955,255
Ensembl chr 7:74,951,145...74,955,251

G

superoxide dismutase 2

increases expression
multiple interactions

Melatonin results in increased expression of SOD2 mRNA
Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of SOD2 mRNA]

PMID:31535366 PMID:37120089

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

steroidogenic acute regulatory protein

increases expression

Melatonin results in increased expression of STAR mRNA

NCBI chr15:48,377,597...48,385,398
Ensembl chr15:48,377,521...48,385,462

G

tight junction protein 1

increases expression
multiple interactions

Melatonin results in increased expression of TJP1 protein
Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of TJP1 protein]

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

tumor necrosis factor

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in increased expression of TNF protein]

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

G

tumor protein p53

decreases expression
multiple interactions

Melatonin results in decreased expression of TP53 mRNA
Melatonin inhibits the reaction [Malathion results in increased expression of TP53 mRNA]

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

vimentin

multiple interactions

[Melatonin co-treated with bisphenol A co-treated with Resveratrol] results in increased expression of and results in increased phosphorylation of VIM protein; [Melatonin co-treated with bisphenol A] results in decreased expression of VIM protein

NCBI chr10:43,516,441...43,526,172
Ensembl chr10:43,517,307...43,526,170

G

ZFP36 ring finger protein like 2

multiple interactions

Melatonin inhibits the reaction [deoxynivalenol results in decreased expression of ZFP36L2 mRNA]

NCBI chr 3:97,200,395...97,203,094
Ensembl chr 3:97,200,407...97,204,698

melittin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 4

decreases response to substance

IL4 protein results in decreased susceptibility to Melitten

NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365

G

phospholipase A2 group IB

increases activity

Melitten results in increased activity of PLA2G1B protein

NCBI chr14:40,314,520...40,322,315
Ensembl chr14:40,314,520...40,322,315

G

selectin E

increases expression

Melitten results in increased expression of SELE mRNA

NCBI chr 4:81,289,061...81,299,657

mesulergine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

5-hydroxytryptamine receptor 2C

multiple interactions
affects binding

8-fluoro-12-(4-methylpiperazin-1-yl)-6H-(1)benzothieno(2,3-b)(1,5)benzodiazepine inhibits the reaction [mesulergine binds to HTR2C protein]

NCBI chr X:94,053,415...94,313,352
Ensembl chr X:94,053,456...94,313,355

methimazole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

flavin containing dimethylaniline monoxygenase 1

increases metabolic processing

FMO1 protein results in increased metabolism of Methimazole

NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076

G

thyroid peroxidase

decreases activity

Methimazole results in decreased activity of TPO protein

NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208

methoctramine tetrahydrochloride

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor muscarinic 2

multiple interactions

methoctramine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM2 protein]

NCBI chr18:12,455,139...12,600,314
Ensembl chr18:12,455,145...12,600,186

metolachlor

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 2 subfamily B member 6B

multiple interactions

CYP2B6B protein results in increased metabolism of and results in decreased susceptibility to metolachlor

NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334

ML-7

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

myosin light chain 9

decreases phosphorylation

ML 7 results in decreased phosphorylation of MYL9 protein

NCBI chr17:39,788,165...39,795,240
Ensembl chr17:39,788,199...39,795,293

G

myosin light chain kinase

multiple interactions

[ML 7 results in decreased activity of MYLK protein] which results in decreased uptake of Calcium

NCBI chr13:136,509,878...136,809,674
Ensembl chr13:136,509,755...136,809,668

monobromobimane

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutathione S-transferase P-like

multiple interactions
decreases activity

GSTP1 protein affects the metabolism of [monobromobimane co-treated with Glutathione]
monobromobimane results in decreased activity of GSTP1 protein

NCBI chr 2:5,005,498...5,009,247

monocrotaline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ornithine decarboxylase 1

increases expression
increases activity

Monocrotaline results in increased expression of ODC1 mRNA
Monocrotaline results in increased activity of ODC1 protein

NCBI chr 3:126,087,013...126,095,644
Ensembl chr 3:126,087,242...126,096,051

G

tenascin C

increases expression
multiple interactions

Monocrotaline results in increased expression of TNC mRNA
1,3-dimethylthiourea inhibits the reaction [Monocrotaline results in increased expression of TNC mRNA]

NCBI chr 1:255,533,235...255,630,381
Ensembl chr 1:255,533,238...255,630,376

monosodium L-glutamate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetyl-CoA carboxylase alpha

multiple interactions
increases expression

Dietary Fats inhibits the reaction [Sodium Glutamate results in increased expression of ACACA mRNA]

NCBI chr12:38,580,916...38,875,067
Ensembl chr12:38,581,457...38,824,712

G

acyl-CoA oxidase 1

increases expression

Sodium Glutamate results in increased expression of ACOX1 mRNA

NCBI chr12:5,450,913...5,479,550
Ensembl chr12:5,439,361...5,479,546

G

fatty acid synthase

increases expression
multiple interactions

Sodium Glutamate results in increased expression of FASN mRNA
Dietary Fats inhibits the reaction [Sodium Glutamate results in increased expression of FASN mRNA]

NCBI chr12:922,405...937,560
Ensembl chr12:920,509...937,561

G

free fatty acid receptor 2

affects expression
multiple interactions

Sodium Glutamate affects the expression of FFAR2 mRNA
Dietary Fats affects the reaction [Sodium Glutamate affects the expression of FFAR2 mRNA]; Sodium Glutamate affects the reaction [Dietary Fats affects the expression of FFAR2 mRNA]

NCBI chr 6:44,899,879...44,904,461
Ensembl chr 6:44,901,159...44,904,459

G

free fatty acid receptor 4

multiple interactions
affects expression

Dietary Fats affects the reaction [Sodium Glutamate affects the expression of FFAR4 mRNA]; Sodium Glutamate affects the reaction [Dietary Fats affects the expression of FFAR4 mRNA]

Ensembl chr14:105,011,942...105,037,498

G

G protein-coupled receptor 119

multiple interactions
affects expression

Dietary Fats affects the reaction [Sodium Glutamate affects the expression of GPR119 mRNA]; Sodium Glutamate affects the reaction [Dietary Fats affects the expression of GPR119 mRNA]

NCBI chr X:106,872,225...106,873,299
Ensembl chr X:106,872,225...106,873,299

G

liver carboxylesterase-like

multiple interactions

Sodium Glutamate inhibits the reaction [Dietary Fats results in decreased expression of CES1 mRNA]

G

patatin like phospholipase domain containing 2

increases expression

Sodium Glutamate results in increased expression of PNPLA2 mRNA

NCBI chr 2:513,065...517,962
Ensembl chr 2:513,077...518,182

G

sterol regulatory element binding transcription factor 1

increases expression
multiple interactions

Sodium Glutamate results in increased expression of SREBF1 mRNA
Dietary Fats inhibits the reaction [Sodium Glutamate results in increased expression of SREBF1 mRNA]

NCBI chr12:60,733,967...60,750,951
Ensembl chr12:60,733,907...60,751,267

N(5)-ethyl-L-glutamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

BCL2 apoptosis regulator

multiple interactions

theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 mRNA]

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

caspase 3

multiple interactions

theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

claudin 1

multiple interactions

[N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of CLDN1 mRNA]; [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of CLDN1 mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN1 mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN1 protein]; theanine inhibits the reaction [Lipopolysaccharides results in decreased expression of CLDN1 mRNA]

PMID:37271275 PMID:38438008

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

interleukin 6

multiple interactions

theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA]

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

lactate dehydrogenase A

multiple interactions

theanine inhibits the reaction [Hydrogen Peroxide results in increased activity of LDHA protein]

NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715

G

interleukin-1 beta-like

multiple interactions

[N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B mRNA]; theanine inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]

PMID:37271275 PMID:38438008

G

mitogen-activated protein kinase 14

multiple interactions

[SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK14 mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of MAPK14 protein]; theanine inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK14 mRNA]

PMID:37271275 PMID:38438008

NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031

G

NLR family pyrin domain containing 3

multiple interactions

[N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA]; [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA]; theanine inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA]

NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228

G

occludin

multiple interactions

[N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of OCLN mRNA]; [SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of OCLN mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of OCLN mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of OCLN protein]; theanine inhibits the reaction [Lipopolysaccharides results in decreased expression of OCLN mRNA]

PMID:37271275 PMID:38438008

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

theanine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of RELA protein]

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

tight junction protein 1

multiple interactions

theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of TJP1 mRNA]; theanine inhibits the reaction [Hydrogen Peroxide results in decreased expression of TJP1 protein]

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

tumor necrosis factor

multiple interactions

theanine inhibits the reaction [Hydrogen Peroxide results in increased expression of TNF mRNA]

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

annexin A5

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]]

NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750

G

caspase 3

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

interleukin 6

multiple interactions
increases expression

[Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]; Zinc inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of IL6 protein]

PMID:14519784 PMID:15226458

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

peroxisome proliferator activated receptor alpha

decreases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PPARA mRNA
Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased expression of PPARA mRNA]

NCBI chr 5:3,302,755...3,321,091
Ensembl chr 5:3,300,741...3,364,239

G

peroxisome proliferator activated receptor gamma

multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of and results in increased activity of PPARG protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc results in increased expression of PPARG mRNA]

NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

caffeic acid phenethyl ester inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 protein]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 mRNA]
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 mRNA; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of PTGS2 protein

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

selectin E

increases expression
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SELE mRNA
Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of SELE mRNA]

NCBI chr 4:81,289,061...81,299,657

G

tumor necrosis factor

increases activity
multiple interactions

N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein
[2,4-thiazolidinedione co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [ciprofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Fenofibrate co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Troglitazone co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]]; [Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of IL6 mRNA]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [Linoleic Acid promotes the reaction [TNF protein results in increased activity of CASP3 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of ANXA5 protein]]]; Zinc Acetate inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased activity of CASP3 protein]]; Zinc Acetate promotes the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein promotes the reaction [Linoleic Acid results in increased activity of CASP3 protein]]]

PMID:10617950 PMID:15226458

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

G

vascular cell adhesion molecule 1

multiple interactions

[Zinc co-treated with 2,4-thiazolidinedione] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine promotes the reaction [TNF protein results in increased expression of VCAM1 mRNA]

NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222

N,N-dimethylaniline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

flavin containing dimethylaniline monoxygenase 1

increases metabolic processing

FMO1 protein results in increased metabolism of N,N-dimethylaniline

NCBI chr 9:63,860,957...63,895,086
Ensembl chr 9:63,868,064...63,895,076

N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cAMP responsive element binding protein 1

multiple interactions

N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Brimonidine Tartrate results in increased phosphorylation of CREB1 protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein]

NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728

G

interleukin 6

multiple interactions
decreases expression

N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of IL6 protein

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

protein kinase cAMP-activated catalytic subunit alpha

multiple interactions

N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein]

NCBI chr 2:65,074,876...65,095,564
Ensembl chr 2:65,074,870...65,095,551

N-acetyl-L-cysteine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased expression of BAX protein]

PMID:19135140 PMID:33905761

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

BCL2 apoptosis regulator

multiple interactions

[Acetylcysteine co-treated with fumonisin B1 co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with deoxynivalenol] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone co-treated with fumonisin B1] results in increased expression of BCL2 protein; [Acetylcysteine co-treated with Zearalenone] results in increased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol results in decreased expression of BCL2 protein]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in decreased expression of BCL2 mRNA]]

PMID:19135140 PMID:29109043 PMID:33905761

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

bone morphogenetic protein 15

multiple interactions

Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of BMP15 mRNA]

NCBI chr X:44,613,122...44,620,575
Ensembl chr X:44,613,122...44,620,575

G

caspase 1, apoptosis-related cysteine peptidase

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of and results in increased cleavage of CASP1 protein]

NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328

G

caspase 3

multiple interactions

[Acetylcysteine co-treated with Zearalenone] results in decreased expression of CASP3 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP3 protein]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[fumonisin B1 co-treated with Zearalenone] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol results in increased expression of CASP3 protein]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[fumonisin B1 co-treated with deoxynivalenol] results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [deoxynivalenol results in increased expression of CASP3 protein]]

PMID:17383151 PMID:19135140 PMID:29109043 PMID:33905761

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 9

multiple interactions

Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein]; Acetylcysteine inhibits the reaction [Cadmium results in increased activity of CASP9 protein]

PMID:19135140 PMID:33905761

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

catalase

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of CAT mRNA]

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

chemokine (C-C motif) ligand 2

multiple interactions

Acetylcysteine inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]

NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026

G

cytochrome c, somatic

multiple interactions

Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [[Zearalenone co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol promotes the reaction [Zearalenone results in increased expression of CYCS mRNA]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [[deoxynivalenol co-treated with fumonisin B1] results in increased expression of CYCS mRNA]]

NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866

G

DNA damage inducible transcript 3

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 mRNA]

NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of FOS mRNA]

NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554

G

glutathione peroxidase 1

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione peroxidase 4

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of GPX4 mRNA]

NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931

G

gasdermin D

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of GSDMD protein]

NCBI chr 4:995,753...1,001,964
Ensembl chr 4:995,763...1,000,271

G

glutathione-disulfide reductase

multiple interactions

Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]; Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 promotes the reaction [deoxynivalenol results in decreased activity of GSR protein]]]

NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,984

G

heat shock protein 90 beta family member 1

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSP90B1 mRNA]

NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 mRNA]

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

G

interleukin-1 beta-like

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of IL1B protein]

G

mitogen-activated protein kinase 8

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK8 protein]

NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874

G

mitogen-activated protein kinase 9

multiple interactions

Acetylcysteine inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK9 protein]

NCBI chr 2:78,338,466...78,399,108
Ensembl chr 2:78,338,376...78,399,100

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

Acetylcysteine inhibits the reaction [Cisplatin results in increased expression of MYC]

NCBI chr 4:12,455,141...12,460,360
Ensembl chr 4:12,455,122...12,461,078

G

NFE2 like bZIP transcription factor 2

multiple interactions

Acetylcysteine inhibits the reaction [Aldosterone results in increased activity of NFE2L2 protein]

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

NLR family pyrin domain containing 3

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of NLRP3 protein]

NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228

G

nitric oxide synthase 2

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of INOS mRNA]

NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of PTGS2 mRNA]

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

pentraxin 3

multiple interactions

Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of PTX3 mRNA]

NCBI chr13:97,273,594...97,279,570
Ensembl chr13:97,273,594...97,279,569

G

PYD and CARD domain containing

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of PYCARD protein]

NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786

G

sequestosome 1

multiple interactions

Acetylcysteine inhibits the reaction [Glyphosate results in decreased expression of SQSTM1 protein]

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

TNF alpha induced protein 6

multiple interactions

Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of TNFAIP6 mRNA]

NCBI chr15:862,013...881,352
Ensembl chr15:862,015...881,461

G

tumor protein p53

multiple interactions

Acetylcysteine inhibits the reaction [fumonisin B1 promotes the reaction [Zearalenone results in increased expression of TP53 mRNA]]; Acetylcysteine inhibits the reaction [Zearalenone promotes the reaction [fumonisin B1 results in increased expression of TP53 mRNA]]; Acetylcysteine promotes the reaction [deoxynivalenol inhibits the reaction [Zearalenone results in increased expression of TP53 mRNA]]

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

zona pellucida glycoprotein 3

multiple interactions

Acetylcysteine inhibits the reaction [Zearalenone results in decreased expression of ZP3 mRNA]

NCBI chr 3:9,934,760...9,944,924
Ensembl chr 3:9,934,760...9,944,941

N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

increases expression
multiple interactions

benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of AKT1 protein
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of AKT1 protein]

G

chloride intracellular channel 5

multiple interactions

benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in decreased expression of CLIC5 protein]

NCBI chr 7:40,683,044...40,808,017
Ensembl chr 7:40,682,907...40,863,886

G

LDL receptor related protein 2

multiple interactions

benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cadmium Chloride results in decreased expression of LRP2 protein]

NCBI chr15:75,565,299...75,754,604
Ensembl chr15:75,565,303...75,716,694

G

nitric oxide synthase 3

multiple interactions
increases expression

benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of NOS3 protein]
benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NOS3 protein

NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943

NAD zwitterion

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldehyde dehydrogenase 7 family member A1

multiple interactions

NAD promotes the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein]

NCBI chr 2:129,663,226...129,709,728
Ensembl chr 2:129,662,969...129,709,705

NAD(+)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aldehyde dehydrogenase 7 family member A1

multiple interactions

NAD promotes the reaction [Hydrogen Peroxide results in decreased activity of ALDH7A1 protein]

NCBI chr 2:129,663,226...129,709,728
Ensembl chr 2:129,662,969...129,709,705

NADP zwitterion

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carbonyl reductase [NADPH] 1-like

affects binding
multiple interactions

NADP binds to CBR1 protein
NADP inhibits the reaction [4-hydroxymercuribenzoate results in decreased activity of CBR1 protein]

NCBI chr13:199,713,741...199,719,535

NADP(+)

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

carbonyl reductase [NADPH] 1-like

affects binding
multiple interactions

NADP binds to CBR1 protein
NADP inhibits the reaction [4-hydroxymercuribenzoate results in decreased activity of CBR1 protein]

NCBI chr13:199,713,741...199,719,535

nicotinamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

forkhead box O1

increases expression

Niacinamide results in increased expression of FOXO1 mRNA

NCBI chr11:15,317,222...15,410,059
Ensembl chr11:15,317,124...15,410,473

G

peroxisome proliferator activated receptor gamma

increases expression

Niacinamide results in increased expression of PPARG mRNA

NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944

G

sirtuin 1

decreases expression

Niacinamide results in decreased expression of SIRT1 mRNA

NCBI chr14:71,091,167...71,126,351
Ensembl chr14:71,091,167...71,123,297

nicotine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenylate cyclase activating polypeptide 1

multiple interactions

Nicotine inhibits the reaction [[Carbon Dioxide co-treated with Oxygen deficiency] results in decreased expression of ADCYAP1 protein]

NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294

G

ADCYAP receptor type I

decreases expression

Nicotine results in decreased expression of ADCYAP1R1 protein

NCBI chr18:41,915,180...41,972,327
Ensembl chr18:41,917,428...41,972,301

G

anti-Mullerian hormone

decreases expression
decreases secretion

Nicotine results in decreased expression of AMH mRNA
Nicotine results in decreased secretion of AMH protein

NCBI chr 2:76,415,564...76,418,315
Ensembl chr 2:76,414,427...76,418,312

G

BCL2 apoptosis regulator

decreases expression

Nicotine results in decreased expression of BCL2 mRNA

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

cholinergic receptor nicotinic alpha 2 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA2 protein]

NCBI chr14:11,193,732...11,204,334
Ensembl chr14:11,195,228...11,207,650

G

cholinergic receptor nicotinic alpha 3 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA3 protein]

NCBI chr 7:47,361,710...47,382,743
Ensembl chr 7:47,361,899...47,384,303

G

cholinergic receptor nicotinic alpha 7 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA7 protein]

NCBI chr 1:142,803,697...142,937,124
Ensembl chr 1:142,803,701...142,937,123

G

cholinergic receptor nicotinic alpha 9 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNA9 protein]

NCBI chr 8:31,430,933...31,456,385
Ensembl chr 8:31,443,043...31,456,384

G

cholinergic receptor nicotinic beta 2 subunit

multiple interactions

Nicotine affects the reaction [[Oxygen deficiency co-treated with Carbon Dioxide] affects the expression of CHRNB2 protein]

NCBI chr 4:95,196,992...95,211,084
Ensembl chr 4:95,198,717...95,211,037

G

cytochrome P450 19A3

decreases expression

Nicotine results in decreased expression of CYP19A1 mRNA

NCBI chr 1:120,476,890...120,556,103
Ensembl chr 1:120,367,667...120,695,899

G

follicle stimulating hormone receptor

decreases expression

Nicotine results in decreased expression of FSHR mRNA

NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683

G

inhibin subunit beta B

decreases secretion
decreases expression

Nicotine results in decreased secretion of INHBB protein
Nicotine results in decreased expression of INHBB mRNA

NCBI chr15:30,999,994...31,004,405
Ensembl chr15:30,999,520...31,004,405

G

integrin subunit beta 1

decreases expression

Nicotine results in decreased expression of ITGB1 mRNA

NCBI chr10:56,078,393...56,130,608
Ensembl chr10:56,078,396...56,173,326

G

laminin subunit beta 1

decreases expression

Nicotine results in decreased expression of LAMB1 mRNA

NCBI chr 9:107,670,120...107,747,242
Ensembl chr 9:107,671,152...107,772,269

G

mitogen-activated protein kinase 1

decreases phosphorylation
decreases expression

Nicotine results in decreased phosphorylation of MAPK1 protein
Nicotine results in decreased expression of MAPK1 mRNA

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 3

decreases expression
decreases phosphorylation

Nicotine results in decreased expression of MAPK3 mRNA
Nicotine results in decreased phosphorylation of MAPK3 protein

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

mitogen-activated protein kinase 8

decreases phosphorylation
decreases expression

Nicotine results in decreased phosphorylation of MAPK8 protein
Nicotine results in decreased expression of MAPK8 mRNA

NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874

G

matrix metallopeptidase 9

increases expression

Nicotine results in increased expression of MMP9 mRNA

NCBI chr17:48,179,690...48,186,782
Ensembl chr17:48,179,671...48,186,788

G

occludin

decreases expression

Nicotine results in decreased expression of OCLN mRNA

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

ribonuclease P/MRP subunit p38

decreases expression

Nicotine results in decreased expression of RPP38 mRNA

NCBI chr10:46,720,135...46,725,962
Ensembl chr10:46,717,197...46,725,920

nifedipine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 3 subfamily A member 29

increases oxidation
multiple interactions

CYP3A29 protein results in increased oxidation of Nifedipine
Ketoconazole inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine]; Troleandomycin inhibits the reaction [CYP3A29 protein results in increased oxidation of Nifedipine]

NCBI chr 3:6,738,502...6,778,121
Ensembl chr 3:6,738,486...6,778,944

nimesulide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

heat shock protein family A (Hsp70) member 5

multiple interactions

nimesulide inhibits the reaction [Hydrogen Peroxide results in increased expression of HSPA5 protein]

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

nitric oxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensin I converting enzyme

multiple interactions

ACE protein inhibits the reaction [KNG1 protein results in increased abundance of Nitric Oxide]

NCBI chr12:15,394,487...15,414,609
Ensembl chr12:15,394,487...15,414,703

G

angiotensinogen

affects activity

Nitric Oxide affects the activity of AGT protein

NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833

G

BCL2 apoptosis regulator

multiple interactions

Nitric Oxide results in increased phosphorylation of and results in decreased activity of BCL2 protein

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

calpain 1

decreases expression

Nitric Oxide results in decreased expression of CAPN1 mRNA

NCBI chr 2:6,997,513...7,024,410
Ensembl chr 2:6,997,985...7,022,684

G

endothelin 1

increases abundance
multiple interactions

EDN1 protein results in increased abundance of Nitric Oxide
Nitric Oxide deficiency inhibits the reaction [Clofibrate results in decreased expression of EDN1 protein]

PMID:12672649 PMID:17105827

NCBI chr 7:8,752,018...8,758,354
Ensembl chr 7:8,751,695...8,758,348

G

kininogen 1

multiple interactions
increases abundance

ACE protein inhibits the reaction [KNG1 protein results in increased abundance of Nitric Oxide]

NCBI chr13:124,521,276...124,557,384
Ensembl chr13:124,521,340...124,557,958

G

nitric oxide synthase 2

multiple interactions

Resveratrol inhibits the reaction [NOS2 protein results in increased chemical synthesis of Nitric Oxide]

NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146

G

nitric oxide synthase 3

multiple interactions
decreases activity

TXNRD1 protein inhibits the reaction [Nitric Oxide results in decreased activity of NOS3 protein]

PMID:8810647 PMID:10823391

NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943

G

tachykinin precursor 1

increases abundance

TAC1 protein results in increased abundance of Nitric Oxide

NCBI chr 9:77,197,403...77,206,529
Ensembl chr 9:77,197,536...77,206,523

G

thioredoxin reductase 1

multiple interactions

TXNRD1 protein inhibits the reaction [Nitric Oxide results in decreased activity of NOS3 protein]

NCBI chr 5:80,170,334...80,213,889
Ensembl chr 5:80,172,260...80,236,219

nitrogen dioxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calpain 1

decreases expression

Nitrogen Dioxide results in decreased expression of CAPN1 mRNA

NCBI chr 2:6,997,513...7,024,410
Ensembl chr 2:6,997,985...7,022,684

nitroglycerin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

protein kinase cGMP-dependent 1

increases activity
multiple interactions
affects expression

Nitroglycerin results in increased activity of PRKG1 protein
Superoxides affects the reaction [Nitroglycerin results in increased activity of PRKG1 protein]
Nitroglycerin affects the expression of PRKG1 mRNA; Nitroglycerin affects the expression of PRKG1 protein

NCBI chr14:97,558,531...98,793,080
Ensembl chr14:97,558,533...98,793,010

norflurazon

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation

norflurazone results in decreased phosphorylation of AKT1 protein

G

AKT serine/threonine kinase 2

decreases phosphorylation

norflurazone results in decreased phosphorylation of AKT2 protein

NCBI chr 6:48,555,785...48,620,472
Ensembl chr 6:48,555,795...48,587,919

G

AKT serine/threonine kinase 3

decreases phosphorylation

norflurazone results in decreased phosphorylation of AKT3 protein

NCBI chr10:16,441,465...16,741,745
Ensembl chr10:16,441,447...16,741,337

G

autophagy related 5

increases expression

norflurazone results in increased expression of ATG5 protein

NCBI chr 1:72,343,950...72,520,402
Ensembl chr 1:72,270,799...72,520,396

G

ATP synthase F1 subunit alpha

decreases expression

norflurazone results in decreased expression of ATP5F1A mRNA

NCBI chr 1:95,738,789...95,750,835
Ensembl chr 1:95,733,090...95,750,841

G

ATP synthase membrane subunit c locus 1

decreases expression

norflurazone results in decreased expression of ATP5MC1 mRNA

NCBI chr12:25,110,540...25,113,481
Ensembl chr12:25,110,528...25,113,478

G

ATP synthase membrane subunit c locus 2

decreases expression

norflurazone results in decreased expression of ATP5MC2 mRNA

NCBI chr 5:18,871,025...18,879,933
Ensembl chr 5:18,871,026...18,879,609

G

ATP synthase peripheral stalk-membrane subunit b

decreases expression

norflurazone results in decreased expression of ATP5PB mRNA

NCBI chr 4:108,896,063...108,907,626
Ensembl chr 4:108,896,057...108,907,805

G

beclin 1

increases expression

norflurazone results in increased expression of BECN1 protein

NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373

G

cytochrome P450 2C49

multiple interactions

CYP2C49 protein results in increased metabolism of and results in decreased susceptibility to norflurazone

NCBI chr14:106,571,803...106,612,082
Ensembl chr14:106,285,173...106,612,455

G

eukaryotic translation initiation factor 2A

increases phosphorylation

norflurazone results in increased phosphorylation of EIF2A protein

NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,274

G

heat shock protein family A (Hsp70) member 5

multiple interactions

norflurazone results in increased expression of and results in increased phosphorylation of HSPA5 protein

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

G

inositol 1,4,5-trisphosphate receptor type 1

increases expression

norflurazone results in increased expression of ITPR1 protein

NCBI chr13:61,068,131...61,398,918
Ensembl chr13:61,068,126...61,398,912

G

mitogen-activated protein kinase 1

decreases phosphorylation

norflurazone results in decreased phosphorylation of MAPK1 protein

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 14

increases phosphorylation

norflurazone results in increased phosphorylation of MAPK14 protein

NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031

G

mitogen-activated protein kinase 3

decreases phosphorylation

norflurazone results in decreased phosphorylation of MAPK3 protein

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

mitochondrially encoded ATP synthase membrane subunit 6

decreases expression

norflurazone results in decreased expression of ATP6 mRNA

NCBI chr MT:9,120...9,800
Ensembl chr MT:9,120...9,800

G

NADH:ubiquinone oxidoreductase core subunit S2

decreases expression

norflurazone results in decreased expression of NDUFS2 mRNA

NCBI chr 4:89,246,958...89,257,090
Ensembl chr 4:89,246,960...89,257,085

G

NADH:ubiquinone oxidoreductase core subunit S3

decreases expression

norflurazone results in decreased expression of NDUFS3 mRNA

NCBI chr 2:15,031,147...15,036,880
Ensembl chr 2:15,031,149...15,036,880

G

NADH:ubiquinone oxidoreductase core subunit V1

decreases expression

norflurazone results in decreased expression of NDUFV1 mRNA

NCBI chr 2:4,958,508...4,964,211
Ensembl chr 2:4,958,522...4,964,216

G

ribosomal protein S6 kinase B1

decreases phosphorylation

norflurazone results in decreased phosphorylation of RPS6KB1 protein

NCBI chr12:36,111,584...36,159,287
Ensembl chr12:36,111,653...36,160,376

G

SMAD family member 2

decreases expression

norflurazone results in decreased expression of SMAD2 mRNA

NCBI chr 1:97,415,360...97,511,388
Ensembl chr 1:97,415,716...97,511,357

G

SMAD family member 4

decreases expression

norflurazone results in decreased expression of SMAD4 mRNA

NCBI chr 1:100,521,843...100,633,501
Ensembl chr 1:100,589,850...100,628,029

G

secreted phosphoprotein 1

decreases expression

norflurazone results in decreased expression of SPP1 mRNA

NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340

G

sequestosome 1

increases phosphorylation

norflurazone results in increased phosphorylation of SQSTM1 protein

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

ubiquinol-cytochrome c reductase binding protein

decreases expression

norflurazone results in decreased expression of UQCRB mRNA

NCBI chr 4:40,403,272...40,409,080
Ensembl chr 4:40,403,109...40,409,057

G

ubiquinol-cytochrome c reductase core protein 2

decreases expression

norflurazone results in decreased expression of UQCRC2 mRNA

NCBI chr 3:24,197,743...24,228,831
Ensembl chr 3:24,197,747...24,228,832

G

ubiquinol-cytochrome c reductase complex III subunit VII

decreases expression

norflurazone results in decreased expression of UQCRQ mRNA

NCBI chr 2:135,186,366...135,188,237
Ensembl chr 2:135,186,501...135,188,293

G

voltage dependent anion channel 1

increases expression

norflurazone results in increased expression of VDAC1 protein

NCBI chr 2:136,302,188...136,334,461
Ensembl chr 2:136,302,191...136,396,301

O-acetyl-L-carnitine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 5

increases uptake

SLC22A5 protein results in increased uptake of Acetylcarnitine

NCBI chr 2:134,660,741...134,847,575
Ensembl chr 2:134,660,808...134,686,219

o-aminoacetophenone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 2 subfamily A member 19

multiple interactions

2-aminoacetophenone inhibits the reaction [[CYP2A19 protein results in increased hydroxylation of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin]; 2-aminoacetophenone inhibits the reaction [CYP2A19 protein results in increased hydroxylation of coumarin]

NCBI chr 6:49,056,579...49,064,111
Ensembl chr 6:49,056,578...49,064,107

G

cytochrome P450 family 2 subfamily E member 1

multiple interactions

2-aminoacetophenone inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; 2-aminoacetophenone inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]

NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817

ochratoxin A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation

ochratoxin A results in decreased phosphorylation of AKT1 protein

G

annexin A5

decreases expression

ochratoxin A results in decreased expression of ANXA5 mRNA

NCBI chr 8:102,387,833...102,420,868
Ensembl chr 8:102,388,103...102,425,750

G

apoptotic peptidase activating factor 1

multiple interactions
increases expression

fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of APAF1 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of APAF1 protein]
ochratoxin A results in increased expression of APAF1 mRNA; ochratoxin A results in increased expression of APAF1 protein

NCBI chr 5:85,166,616...85,258,751
Ensembl chr 5:85,166,628...85,258,364

G

autophagy related 5

increases expression
multiple interactions

ochratoxin A results in increased expression of ATG5 protein
ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]

PMID:28699257 PMID:30287338

NCBI chr 1:72,343,950...72,520,402
Ensembl chr 1:72,270,799...72,520,396

G

BCL2 associated X, apoptosis regulator

increases expression
multiple interactions

ochratoxin A results in increased expression of BAX mRNA; ochratoxin A results in increased expression of BAX protein
[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX protein]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of BAX mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of BAX protein]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of BAX mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of BAX protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of BAX mRNA]

PMID:33905761 PMID:36397609

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

BCL2 apoptosis regulator

affects expression
decreases expression
multiple interactions

ochratoxin A affects the expression of BCL2 mRNA
ochratoxin A results in decreased expression of BCL2 mRNA; ochratoxin A results in decreased expression of BCL2 protein
[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 protein; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 protein]; fumonisin B1 promotes the reaction [ochratoxin A results in decreased expression of BCL2 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in decreased expression of BCL2 protein]; ochratoxin A promotes the reaction [fumonisin B1 results in decreased expression of BCL2 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in decreased expression of BCL2 protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in decreased expression of BCL2 mRNA]; TLR4 protein affects the reaction [ochratoxin A affects the expression of BCL2 mRNA]

PMID:28528741 PMID:29080797 PMID:33905761 PMID:36397609

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

beclin 1

increases expression
multiple interactions

ochratoxin A results in increased expression of BECN1 protein
BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]

NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373

G

BRCA1 DNA repair associated

increases expression

ochratoxin A results in increased expression of BRCA1 protein

NCBI chr12:19,788,087...19,854,515
Ensembl chr12:19,786,020...19,854,668

G

caspase 1, apoptosis-related cysteine peptidase

multiple interactions

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of and results in increased cleavage of CASP1 protein]; ochratoxin A results in increased expression of and results in increased cleavage of CASP1 protein; Taurine inhibits the reaction [ochratoxin A results in increased expression of and results in increased cleavage of CASP1 protein]

NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328

G

caspase 3

increases cleavage
increases expression
multiple interactions

ochratoxin A results in increased cleavage of CASP3 protein
ochratoxin A results in increased expression of CASP3 mRNA; ochratoxin A results in increased expression of CASP3 protein; ochratoxin A results in increased expression of CASP3 protein modified form
3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; fumonisin B1 promotes the reaction [ochratoxin A results in increased cleavage of CASP3 protein]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP3 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP3 protein modified form]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP3 protein]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP3 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP3 protein modified form]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP3 protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 mRNA]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein modified form]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP3 protein]

PMID:30287338 PMID:33905761 PMID:36397609

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

caspase 9

multiple interactions
increases expression

[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein; [fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form]; Acetylcysteine inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP9 mRNA]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP9 protein modified form]; fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CASP9 protein]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP9 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP9 protein modified form]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of CASP9 protein]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 mRNA]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein modified form]; pyrazolanthrone inhibits the reaction [[fumonisin B1 co-treated with ochratoxin A] results in increased expression of CASP9 protein]
ochratoxin A results in increased expression of CASP9 mRNA; ochratoxin A results in increased expression of CASP9 protein; ochratoxin A results in increased expression of CASP9 protein modified form

PMID:33905761 PMID:36397609

NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007

G

catalase

decreases expression
multiple interactions

ochratoxin A results in decreased expression of CAT mRNA; ochratoxin A results in decreased expression of CAT protein
Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of CAT mRNA]; Taurine inhibits the reaction [ochratoxin A results in decreased expression of CAT mRNA]

PMID:18547704 PMID:36281498

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

crystallin alpha B

increases expression

ochratoxin A results in increased expression of CRYAB mRNA

NCBI chr 9:39,638,505...39,643,530
Ensembl chr 9:39,638,506...39,643,530

G

cytochrome c, somatic

increases expression
multiple interactions

ochratoxin A results in increased expression of CYCS mRNA
fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of CYCS mRNA]

NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866

G

cytochrome P450 family 2 subfamily G member 2

decreases expression

ochratoxin A results in decreased expression of CYP2A6 mRNA

NCBI chr 6:49,069,613...49,084,953

G

defender against cell death 1

decreases expression

ochratoxin A results in decreased expression of DAD1 mRNA

NCBI chr 7:76,432,040...76,457,403
Ensembl chr 7:76,432,051...76,457,192

G

DNA methyltransferase 1

multiple interactions
increases expression

Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of DNMT1 protein]
ochratoxin A results in increased expression of DNMT1 mRNA; ochratoxin A results in increased expression of DNMT1 protein

PMID:29080797 PMID:30923867

NCBI chr 2:68,981,564...69,040,364
Ensembl chr 2:68,981,566...69,029,844

G

DNA methyltransferase 3 alpha

increases expression

ochratoxin A results in increased expression of DNMT3A mRNA

PMID:29080797 PMID:30923867

NCBI chr 3:113,501,972...113,609,148
Ensembl chr 3:113,528,926...113,603,087

G

glutamate-cysteine ligase catalytic subunit

decreases expression
multiple interactions

ochratoxin A results in decreased expression of GCLC mRNA
ochratoxin A inhibits the reaction [sulforaphane results in increased expression of GCLC mRNA]

NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530

G

glomulin, FKBP associated protein

increases expression

ochratoxin A results in increased expression of GLMN mRNA

NCBI chr 4:124,773,957...124,813,336
Ensembl chr 4:124,773,980...124,813,335

G

glutathione peroxidase 1

multiple interactions
decreases expression

Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]; Taurine inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione peroxidase 4

decreases expression
multiple interactions

ochratoxin A results in decreased expression of GPX4 mRNA
Acetylcysteine inhibits the reaction [ochratoxin A results in decreased expression of GPX4 mRNA]; Taurine inhibits the reaction [ochratoxin A results in decreased expression of GPX4 mRNA]

NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931

G

gasdermin D

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of GSDMD protein]; Taurine inhibits the reaction [ochratoxin A results in increased expression of GSDMD protein]

NCBI chr 4:995,753...1,001,964
Ensembl chr 4:995,763...1,000,271

G

H2A.X variant histone

multiple interactions
increases expression

alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in increased expression of H2AX protein]; Decitabine inhibits the reaction [ochratoxin A results in increased expression of H2AX protein]; STAT3 protein affects the reaction [ochratoxin A results in increased expression of H2AX protein]

PMID:30923867 PMID:32454083

NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084

G

hepatitis A virus cellular receptor 1

multiple interactions

[fumonisin B1 co-treated with ochratoxin A] results in increased expression of HAVCR1 mRNA

NCBI chr16:66,162,318...66,208,868

G

histone deacetylase 1

multiple interactions
increases expression

Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 mRNA]; Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 protein]
ochratoxin A results in increased expression of HDAC1 mRNA; ochratoxin A results in increased expression of HDAC1 protein

NCBI chr 6:88,749,611...88,785,220
Ensembl chr 6:88,749,634...88,785,411

G

heat shock protein 90 beta family member 1

increases expression
decreases expression

ochratoxin A results in increased expression of HSP90B1 mRNA
ochratoxin A results in decreased expression of HSP90B1 mRNA

NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991

G

heat shock protein family A (Hsp70) member 5

increases expression

ochratoxin A results in increased expression of HSPA5 mRNA; ochratoxin A results in increased expression of HSPA5 protein

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

G

heat shock protein family D (Hsp60) member 1

decreases expression

ochratoxin A results in decreased expression of HSPD1 mRNA

NCBI chr15:101,360,355...101,373,498
Ensembl chr15:101,360,094...101,373,526

G

inhibitor of DNA binding 2

decreases expression

ochratoxin A results in decreased expression of ID2 mRNA

NCBI chr 3:127,500,759...127,503,207
Ensembl chr 3:127,500,763...127,503,257

G

insulin like growth factor binding protein 2

increases expression

ochratoxin A results in increased expression of IGFBP2 mRNA

NCBI chr15:118,822,092...118,850,985
Ensembl chr15:118,822,047...118,850,976

G

interleukin 18

increases expression

ochratoxin A results in increased expression of IL18 protein

NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219

G

interleukin 1 alpha

multiple interactions

ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]]

NCBI chr 3:43,718,320...43,731,668
Ensembl chr 3:43,718,368...43,731,121

G

interleukin 2

decreases secretion

ochratoxin A results in decreased secretion of IL2 protein

NCBI chr 8:101,640,938...101,645,683
Ensembl chr 8:101,640,944...101,645,609

G

interleukin 4

increases expression

ochratoxin A results in increased expression of IL4 mRNA

NCBI chr 2:134,986,817...134,994,365
Ensembl chr 2:134,986,817...134,994,365

G

interleukin 6

multiple interactions
increases expression

NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of IL6 mRNA]

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

Janus kinase 2

increases phosphorylation
multiple interactions

ochratoxin A results in increased phosphorylation of JAK2 protein
Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of JAK2 protein]

NCBI chr 1:216,849,744...217,002,310
Ensembl chr 1:216,848,689...217,002,148

G

lipocalin 2

multiple interactions

[fumonisin B1 co-treated with ochratoxin A] results in increased expression of LCN2 mRNA

NCBI chr 1:268,609,975...268,614,651
Ensembl chr 1:268,609,887...268,614,644

G

glutathione S-transferase alpha M14

multiple interactions
decreases expression

ochratoxin A inhibits the reaction [sulforaphane results in increased expression of GSTA1 mRNA]
ochratoxin A results in decreased expression of GSTA1 mRNA

NCBI chr 7:46,553,813...46,567,596

G

interleukin-1 beta-like

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of IL1B protein]; Taurine inhibits the reaction [ochratoxin A results in increased expression of IL1B protein]

G

mitogen-activated protein kinase 1

multiple interactions
increases phosphorylation

ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
ochratoxin A results in increased phosphorylation of MAPK1 protein

PMID:28528741 PMID:28699257

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 3

multiple interactions
increases phosphorylation

ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]
ochratoxin A results in increased phosphorylation of MAPK3 protein

PMID:28528741 PMID:28699257

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

mechanistic target of rapamycin kinase

decreases phosphorylation

ochratoxin A results in decreased phosphorylation of MTOR protein

NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888

G

MYD88 innate immune signal transduction adaptor

multiple interactions

ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 mRNA]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]

NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109

G

nei like DNA glycosylase 1

multiple interactions
decreases expression

alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]

NCBI chr 7:58,261,761...58,269,001
Ensembl chr 7:58,261,769...58,268,522

G

nei like DNA glycosylase 3

decreases expression
multiple interactions

ochratoxin A results in decreased expression of NEIL3 mRNA
alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]

NCBI chr15:39,416,073...39,632,313
Ensembl chr15:39,581,856...39,632,308

G

NFE2 like bZIP transcription factor 2

decreases expression
multiple interactions
decreases activity

ochratoxin A results in decreased expression of NFE2L2 mRNA
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of IL6 mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TP53 protein]; ochratoxin A inhibits the reaction [sulforaphane affects the localization of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforaphane results in increased activity of NFE2L2 protein]; ochratoxin A inhibits the reaction [sulforaphane results in increased expression of NFE2L2 mRNA]
ochratoxin A results in decreased activity of NFE2L2 protein

PMID:18547363 PMID:18547704 PMID:28710020

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

G

NLR family pyrin domain containing 3

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of NLRP3 protein]; Taurine inhibits the reaction [ochratoxin A results in increased expression of NLRP3 protein]

NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228

G

nitric oxide synthase 2

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of INOS mRNA]; Taurine inhibits the reaction [ochratoxin A results in decreased expression of INOS mRNA]

NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146

G

nucleophosmin 1

increases expression

ochratoxin A results in increased expression of NPM1 mRNA

NCBI chr16:52,767,263...52,781,862
Ensembl chr16:52,765,298...52,781,771

G

netrin 1

multiple interactions
increases expression

fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of NTN1 mRNA]

NCBI chr12:54,089,444...54,292,191
Ensembl chr12:54,089,472...54,292,193

G

8-oxoguanine DNA glycosylase

multiple interactions
decreases expression

alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; Decitabine inhibits the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]

NCBI chr13:66,038,669...66,045,478

G

poly(ADP-ribose) polymerase 1

multiple interactions
increases expression
increases cleavage

3-methyladenine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; ATG5 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; BECN1 protein affects the reaction [ochratoxin A results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [ochratoxin A results in increased cleavage of PARP1 protein]
ochratoxin A results in increased expression of PARP1 protein

PMID:30287338 PMID:32454083

NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196

G

phosphoenolpyruvate carboxykinase 1

decreases expression

ochratoxin A results in decreased expression of PCK1 mRNA; ochratoxin A results in decreased expression of PCK1 protein

NCBI chr17:57,930,507...57,936,523
Ensembl chr17:57,930,432...57,936,522

G

proliferating cell nuclear antigen

decreases expression

ochratoxin A results in decreased expression of PCNA protein

NCBI chr17:14,137,746...14,142,584
Ensembl chr17:14,136,886...14,142,744

G

prefoldin subunit 5

decreases expression

ochratoxin A results in decreased expression of PFDN5 mRNA

NCBI chr 5:18,512,637...18,516,928
Ensembl chr 5:18,512,697...18,517,174

G

peptidylprolyl isomerase A

increases expression

ochratoxin A results in increased expression of PPIA mRNA

NCBI chr18:50,563,130...50,566,857

G

peroxiredoxin 1

decreases expression

ochratoxin A results in decreased expression of PRDX1 mRNA

NCBI chr 6:165,847,390...165,859,918
Ensembl chr 6:165,824,395...165,861,442

G

prostaglandin-endoperoxide synthase 2

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of PTGS2 mRNA]; Taurine inhibits the reaction [ochratoxin A results in decreased expression of PTGS2 mRNA]

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

prothymosin alpha

decreases expression

ochratoxin A results in decreased expression of PTMA mRNA

NCBI chr15:132,353,763...132,361,442
Ensembl chr15:132,355,655...132,361,435

G

PYD and CARD domain containing

multiple interactions
increases expression

Acetylcysteine inhibits the reaction [ochratoxin A results in increased expression of PYCARD protein]; Taurine inhibits the reaction [ochratoxin A results in increased expression of PYCARD protein]

NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786

G

RAD51 recombinase

increases expression

ochratoxin A results in increased expression of RAD51 protein

NCBI chr 1:130,592,414...130,640,326
Ensembl chr 1:130,586,665...130,640,136

G

RELA proto-oncogene, NF-kB subunit

multiple interactions

ochratoxin A inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]

NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469

G

replication protein A2

increases expression

ochratoxin A results in increased expression of RPA2 protein

NCBI chr 6:85,032,604...85,045,899
Ensembl chr 6:85,031,582...85,045,915

G

ribosomal protein S5

increases expression

ochratoxin A results in increased expression of RPS5 mRNA

NCBI chr 6:62,967,955...62,974,353
Ensembl chr 6:62,967,994...62,974,350

G

suppressor of cytokine signaling 3

increases expression
multiple interactions

ochratoxin A results in increased expression of SOCS3 mRNA; ochratoxin A results in increased expression of SOCS3 protein
Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 mRNA]; Decitabine promotes the reaction [ochratoxin A results in increased expression of SOCS3 protein]

NCBI chr12:3,643,832...3,647,015
Ensembl chr12:3,643,929...3,647,009

G

superoxide dismutase 1

decreases activity

ochratoxin A results in decreased activity of SOD1 protein

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

secreted phosphoprotein 1

multiple interactions
increases expression

fumonisin B1 promotes the reaction [ochratoxin A results in increased expression of SPP1 mRNA]; ochratoxin A promotes the reaction [fumonisin B1 results in increased expression of SPP1 mRNA]

NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340

G

sequestosome 1

multiple interactions
decreases expression

Chloroquine inhibits the reaction [ochratoxin A results in decreased expression of SQSTM1 protein]

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

signal transducer and activator of transcription 3

multiple interactions
increases phosphorylation

Decitabine inhibits the reaction [ochratoxin A results in increased phosphorylation of STAT3 protein]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of NEIL3 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in decreased expression of OGG1 mRNA]; STAT3 protein affects the reaction [ochratoxin A results in increased expression of H2AX protein]

NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992

G

small ubiquitin like modifier 1

decreases expression

ochratoxin A results in decreased expression of SUMO1 mRNA

NCBI chr15:105,820,237...105,850,099
Ensembl chr15:105,818,858...105,850,233

G

transforming growth factor beta 1

multiple interactions
increases expression

NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; sulforaphane inhibits the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]

NCBI chr 6:49,332,169...49,348,642
Ensembl chr 6:49,332,173...49,349,046

G

TIMP metallopeptidase inhibitor 2

increases expression

ochratoxin A results in increased expression of TIMP2 mRNA

NCBI chr12:3,254,794...3,300,835
Ensembl chr12:3,254,493...3,300,834

G

tight junction protein 1

affects localization

ochratoxin A affects the localization of TJP1 protein

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

toll like receptor 4

multiple interactions

ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TLR4 protein affects the reaction [ochratoxin A affects the expression of BCL2 mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of IL1A mRNA]]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]

NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970

G

tumor necrosis factor

multiple interactions
increases secretion

ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; TLR4 protein affects the reaction [ochratoxin A promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
ochratoxin A results in increased secretion of TNF protein

PMID:28528741 PMID:28699257

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

G

tumor protein p53

increases expression
multiple interactions

ochratoxin A results in increased expression of TP53 protein
NFE2L2 protein affects the reaction [ochratoxin A results in increased expression of TP53 protein]

PMID:28710020 PMID:32454083

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

XPA, DNA damage recognition and repair factor

decreases expression

ochratoxin A results in decreased expression of XPA mRNA

NCBI chr 1:239,532,331...239,568,589
Ensembl chr 1:239,532,272...239,568,570

G

X-ray repair cross complementing 1

increases expression

ochratoxin A results in increased expression of XRCC1 protein

NCBI chr 6:50,403,691...50,425,730
Ensembl chr 6:50,403,689...50,425,729

ochratoxin B

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

NFE2 like bZIP transcription factor 2

decreases activity

ochratoxin B results in decreased activity of NFE2L2 protein

NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183

omega-conotoxin GVIA

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenylate cyclase activating polypeptide 1

multiple interactions

omega-Conotoxin GVIA inhibits the reaction [ADCYAP1 protein alternative form results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid]

NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294

G

opioid receptor mu 1

multiple interactions

omega-Conotoxin GVIA inhibits the reaction [Enkephalin, Ala(2)-MePhe(4)-Gly(5)- inhibits the reaction [OPRM1 protein results in increased transport of Barium]]

NCBI chr 1:12,634,125...12,702,295
Ensembl chr 1:12,528,672...12,702,443

G

vasoactive intestinal peptide

multiple interactions

omega-Conotoxin GVIA inhibits the reaction [VIP protein results in decreased susceptibility to 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid]

NCBI chr 1:13,611,786...13,620,250
Ensembl chr 1:13,611,311...13,620,269

organophosphorus compound

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

pancreatic lipase

decreases activity

Organophosphorus Compounds results in decreased activity of PNLIP protein

NCBI chr14:126,771,920...126,789,097
Ensembl chr14:126,772,911...126,790,001

orlistat

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

pancreatic lipase

decreases activity

Orlistat results in decreased activity of PNLIP protein

NCBI chr14:126,771,920...126,789,097
Ensembl chr14:126,772,911...126,790,001

Oxotremorine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor muscarinic 2

multiple interactions

[Oxotremorine binds to CHRM2 protein] affects the reaction [1,3-bis(4-(phthalimidomethoxyiminomethyl)pyridinium-1-yl)propane binds to CHRM2 protein]

NCBI chr18:12,455,139...12,600,314
Ensembl chr18:12,455,145...12,600,186

oxytocin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ghrelin and obestatin prepropeptide

multiple interactions
increases secretion

STAT1 protein inhibits the reaction [GHRL protein results in increased secretion of Oxytocin]

NCBI chr13:66,442,106...66,453,576
Ensembl chr13:66,445,992...66,452,917

G

signal transducer and activator of transcription 1

increases secretion
multiple interactions

STAT1 protein results in increased secretion of Oxytocin
STAT1 protein inhibits the reaction [GHRL protein results in increased secretion of Oxytocin]

NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260

panobinostat

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

BCL2 associated X, apoptosis regulator

multiple interactions

Panobinostat inhibits the reaction [Cyclophosphamide results in increased expression of BAX mRNA]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

BCL2 apoptosis regulator

multiple interactions

Panobinostat inhibits the reaction [Cyclophosphamide results in decreased expression of BCL2 mRNA]

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

H2A.X variant histone

multiple interactions

Panobinostat inhibits the reaction [Cyclophosphamide results in increased expression of H2AX protein]

NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084

G

histone deacetylase 1

multiple interactions

Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 mRNA]; Panobinostat inhibits the reaction [ochratoxin A results in increased expression of HDAC1 protein]

NCBI chr 6:88,749,611...88,785,220
Ensembl chr 6:88,749,634...88,785,411

G

Nanog homeobox

multiple interactions

[Panobinostat co-treated with Cyclophosphamide] results in increased expression of NANOG mRNA

NCBI chr 5:62,931,642...62,939,086
Ensembl chr 5:62,932,382...62,939,082

G

POU class 5 homeobox 1

multiple interactions

Panobinostat inhibits the reaction [Cyclophosphamide results in decreased expression of POU5F1 mRNA]

NCBI chr 7:23,564,654...23,570,691

G

superoxide dismutase 1

multiple interactions

Panobinostat inhibits the reaction [Cyclophosphamide results in decreased expression of SOD1 mRNA]

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

SRY-box transcription factor 2

multiple interactions

Panobinostat inhibits the reaction [Cyclophosphamide results in decreased expression of SOX2 mRNA]

NCBI chr13:119,668,476...119,669,435
Ensembl chr13:119,668,476...119,669,435

paracetamol

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cyclin dependent kinase inhibitor 1A

decreases expression

Acetaminophen results in decreased expression of CDKN1A protein

NCBI chr 7:32,354,776...32,363,771
Ensembl chr 7:32,354,672...32,363,761

G

tumor protein p53

decreases expression

Acetaminophen results in decreased expression of TP53 protein

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

paraoxon

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

decreases activity
multiple interactions

Paraoxon results in decreased activity of ACHE protein
asoxime chloride inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Obidoxime Chloride inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; pralidoxime inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]

PMID:19428926 PMID:20156534 PMID:20971170 PMID:22230262

NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,441...8,738,605

G

butyrylcholinesterase

decreases activity

Paraoxon results in decreased activity of BCHE protein

NCBI chr13:104,946,732...105,007,568

paraquat

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aconitase 1

decreases activity

Paraquat results in decreased activity of ACO1 protein

NCBI chr10:33,937,833...34,001,895
Ensembl chr10:33,937,833...34,001,900

G

amine oxidase copper containing 1

increases expression
multiple interactions

Paraquat results in increased expression of AOC1 protein
Glutathione inhibits the reaction [Paraquat results in increased expression of AOC1 protein]

NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974

G

BCL2 apoptosis regulator

decreases expression
multiple interactions

Paraquat results in decreased expression of BCL2 protein
MYD88 protein affects the reaction [Paraquat results in decreased expression of BCL2 protein]

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

BCL2 like 1

multiple interactions
decreases expression

MYD88 protein affects the reaction [Paraquat results in decreased expression of BCL2L1 mRNA]

NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694

G

beclin 1

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA; Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]

NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373

G

caspase 3

increases expression
multiple interactions

Paraquat results in increased expression of CASP3 mRNA
MYD88 protein affects the reaction [Paraquat results in increased activity of and results in increased cleavage of CASP3 protein]; MYD88 protein affects the reaction [Paraquat results in increased expression of CASP3 mRNA]; Paraquat results in increased activity of and results in increased cleavage of CASP3 protein

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

catalase

decreases response to substance
multiple interactions

CAT protein results in decreased susceptibility to Paraquat
3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the activity of CAT protein]; [MYD88 protein affects the susceptibility to Paraquat] which affects the activity of CAT protein; CAT protein inhibits the reaction [Paraquat results in increased abundance of Hydrogen Peroxide]

PMID:10752666 PMID:11039594 PMID:34811946

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

cyclin dependent kinase 2

increases expression
multiple interactions

Paraquat results in increased expression of CDK2 protein
MYD88 protein affects the reaction [Paraquat results in increased expression of CDK2 protein]

NCBI chr 5:21,365,723...21,372,170
Ensembl chr 5:21,365,764...21,372,168

G

claudin 1

decreases expression

Paraquat results in decreased expression of CLDN1 protein

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

cytochrome P450 family 2 subfamily B member 6B

multiple interactions
increases expression

[Glutathione co-treated with Paraquat] results in decreased expression of CYP2B6B mRNA
Paraquat results in increased expression of CYP2B6B mRNA

NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334

G

cytochrome P450 3A39

increases expression
multiple interactions

Paraquat results in increased expression of CYP3A39 mRNA
Glutathione inhibits the reaction [Paraquat results in increased expression of CYP3A39 mRNA]

G

dynactin subunit 4

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]

NCBI chr 2:151,681,001...151,713,923
Ensembl chr 2:151,681,003...151,783,746

G

DnaJ heat shock protein family (Hsp40) member C7

multiple interactions

[Glutathione co-treated with Paraquat] results in increased expression of DNAJC7 mRNA

NCBI chr12:20,725,937...20,756,295
Ensembl chr12:20,725,975...20,759,000

G

fatty acid binding protein 2

multiple interactions
increases activity

Glutathione inhibits the reaction [Paraquat results in increased activity of FABP2 protein]

NCBI chr 8:104,464,342...104,468,059
Ensembl chr 8:104,464,342...104,470,480

G

FYVE, RhoGEF and PH domain containing 4

multiple interactions
increases expression

3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L protein]]; MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]; MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L protein]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]
Paraquat results in increased expression of DNM1L mRNA; Paraquat results in increased expression of DNM1L protein

NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028

G

fission, mitochondrial 1

increases expression
multiple interactions
affects expression

Paraquat results in increased expression of FIS1 mRNA
3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]; MYD88 protein affects the reaction [Paraquat affects the expression of FIS1 protein]; MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of FIS1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]

NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,937,453...8,946,955

G

glucose-6-phosphate dehydrogenase

affects activity

Paraquat affects the activity of G6PD protein

NCBI chr X:125,029,147...125,041,040
Ensembl chr X:125,029,150...125,041,040

G

glyceraldehyde-3-phosphate dehydrogenase

multiple interactions
decreases activity

Selenium inhibits the reaction [Paraquat results in decreased activity of GAPDH protein]

PMID:11814328 PMID:17055214

NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991

G

glutamate-cysteine ligase modifier subunit

multiple interactions

[Glutathione co-treated with Paraquat] results in increased expression of GCLM mRNA

NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,131

G

glutathione peroxidase 1

multiple interactions

3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 protein; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione peroxidase 4

multiple interactions
increases expression

[Glutathione co-treated with Paraquat] results in increased expression of GPX4 mRNA
Paraquat results in increased expression of GPX4 mRNA

NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931

G

glutathione-disulfide reductase

affects activity

Paraquat affects the activity of GSR protein

NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,984

G

heat shock protein 90 alpha family class A member 1

multiple interactions

[Glutathione co-treated with Paraquat] results in decreased expression of HSP90AA1 mRNA

G

interferon gamma

multiple interactions
increases expression

Glutathione inhibits the reaction [Paraquat results in increased expression of IFNG mRNA]

NCBI chr 5:32,477,906...32,482,670
Ensembl chr 5:32,477,906...32,482,670

G

interleukin 10

multiple interactions

[Glutathione co-treated with Paraquat] results in increased expression of IL10 mRNA

NCBI chr 9:67,400,727...67,405,941
Ensembl chr 9:67,400,728...67,405,378

G

glutathione S-transferase alpha M14

decreases expression
multiple interactions

Paraquat results in decreased expression of GSTA1 mRNA
[Glutathione co-treated with Paraquat] results in increased expression of GSTA2 mRNA; Glutathione inhibits the reaction [Paraquat results in decreased expression of GSTA1 mRNA]

NCBI chr 7:46,553,813...46,567,596

G

interleukin-1 beta-like

increases expression

Paraquat results in increased expression of IL1B mRNA

G

microtubule associated protein 1 light chain 3 beta

multiple interactions

3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]; Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]

NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069

G

marker of proliferation Ki-67

decreases expression
multiple interactions

Paraquat results in decreased expression of MKI67 protein
3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of MKI67 protein]]; MYD88 protein affects the reaction [Paraquat results in decreased expression of MKI67 protein]

NCBI chr14:137,266,622...137,296,312

G

mechanistic target of rapamycin kinase

decreases phosphorylation
multiple interactions

Paraquat results in decreased phosphorylation of MTOR protein
MYD88 protein affects the reaction [Paraquat results in decreased phosphorylation of MTOR protein]

NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888

G

MYD88 innate immune signal transduction adaptor

increases response to substance
increases expression
multiple interactions

MYD88 protein results in increased susceptibility to Paraquat
Paraquat results in increased expression of MYD88 protein
3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the activity of CAT protein]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]; 3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of MKI67 protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of TOMM20 protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L protein]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]; 3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of PARP1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]; 3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]]; [MYD88 protein affects the susceptibility to Paraquat] which affects the activity of CAT protein; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 protein; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 protein; MYD88 protein affects the reaction [Paraquat affects the expression of FIS1 protein]; MYD88 protein affects the reaction [Paraquat affects the expression of OPA1 protein]; MYD88 protein affects the reaction [Paraquat results in decreased expression of BCL2 protein]; MYD88 protein affects the reaction [Paraquat results in decreased expression of BCL2L1 mRNA]; MYD88 protein affects the reaction [Paraquat results in decreased expression of MKI67 protein]; MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]; MYD88 protein affects the reaction [Paraquat results in decreased expression of TOMM20 protein]; MYD88 protein affects the reaction [Paraquat results in decreased phosphorylation of MTOR protein]; MYD88 protein affects the reaction [Paraquat results in increased activity of and results in increased cleavage of CASP3 protein]; MYD88 protein affects the reaction [Paraquat results in increased expression of CASP3 mRNA]; MYD88 protein affects the reaction [Paraquat results in increased expression of CDK2 protein]; MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]; MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L protein]; MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]; MYD88 protein affects the reaction [Paraquat results in increased expression of PARP1 protein]; Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]; Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]; Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]; Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of FIS1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of OPA1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]

NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109

G

nuclear receptor subfamily 1 group I member 3

multiple interactions
increases expression

Glutathione inhibits the reaction [Paraquat results in increased expression of NR1I3 mRNA]

NCBI chr 4:89,226,314...89,231,781
Ensembl chr 4:89,226,690...89,236,431

G

occludin

multiple interactions
decreases expression

Glutathione inhibits the reaction [Paraquat results in decreased expression of OCLN protein]

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

OPA1 mitochondrial dynamin like GTPase

multiple interactions
decreases expression
affects expression

3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]; MYD88 protein affects the reaction [Paraquat affects the expression of OPA1 protein]; MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of OPA1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]

NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083

G

poly(ADP-ribose) polymerase 1

increases expression
multiple interactions

Paraquat results in increased expression of PARP1 protein
3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of PARP1 protein]]; MYD88 protein affects the reaction [Paraquat results in increased expression of PARP1 protein]

NCBI chr10:14,203,157...14,241,164
Ensembl chr10:14,203,160...14,241,196

G

protein phosphatase 2 catalytic subunit alpha

increases expression

Paraquat results in increased expression of PPP2CA mRNA

NCBI chr 2:136,497,780...136,522,630
Ensembl chr 2:136,494,541...136,522,646

G

superoxide dismutase 1

increases expression
multiple interactions

Paraquat results in increased expression of SOD1 mRNA
3-methyladenine affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA; [MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 protein; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]

PMID:34811946 PMID:36615853

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

superoxide dismutase 2

multiple interactions

[Glutathione co-treated with Paraquat] affects the expression of SOD2 mRNA

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

sequestosome 1

multiple interactions

3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]; Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

tight junction protein 1

multiple interactions
decreases expression

Glutathione inhibits the reaction [Paraquat results in decreased expression of TJP1 protein]

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

translocase of outer mitochondrial membrane 20

multiple interactions
decreases expression

3-methyladenine affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of TOMM20 protein]]; MYD88 protein affects the reaction [Paraquat results in decreased expression of TOMM20 protein]

NCBI chr14:56,113,087...56,127,686
Ensembl chr14:56,113,192...56,127,677

G

tumor protein p53

multiple interactions

3-methyladenine affects the reaction [Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]]; Paraquat affects the reaction [MYD88 protein affects the phosphorylation of TP53 protein]

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

thioredoxin reductase 1

multiple interactions
decreases activity

Selenium inhibits the reaction [Paraquat results in decreased activity of TXNRD1 protein]

NCBI chr 5:80,170,334...80,213,889
Ensembl chr 5:80,172,260...80,236,219

Pargyline

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

monoamine oxidase B

decreases activity

Pargyline analog results in decreased activity of MAOB protein

NCBI chr X:39,025,973...39,144,389
Ensembl chr X:39,025,970...39,144,345

pendimethalin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 2 subfamily B member 6B

decreases response to substance

CYP2B6B protein results in decreased susceptibility to pendimethalin

NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334

pepstatin A

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

leukotriene A4 hydrolase

decreases activity

pepstatin results in decreased activity of LTA4H protein

NCBI chr 5:87,486,552...87,518,520
Ensembl chr 5:87,486,512...87,518,515

G

pepsinogen 5, group I (pepsinogen A)

decreases activity

pepstatin analog results in decreased activity of PGA5 protein

NCBI chr 2:10,244,300...10,252,644
Ensembl chr 2:10,244,187...10,252,680

peroxynitrous acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

heme oxygenase 1

increases expression

Peroxynitrous Acid results in increased expression of HMOX1 protein

phenobarbital

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 2 subfamily B member 6B

increases expression

Phenobarbital results in increased expression of CYP2B6B protein

NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334

Phenylamil

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amine oxidase copper containing 1

affects binding

phenylamil binds to AOC1 protein

NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974

phenylarsine oxide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

dual oxidase 2

affects folding

oxophenylarsine affects the folding of DUOX2 protein

NCBI chr 1:126,620,468...126,641,406
Ensembl chr 1:126,620,510...126,641,406

G

hypoxia inducible factor 1 subunit alpha

increases expression

oxophenylarsine results in increased expression of HIF1A protein

NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845

G

insulin

multiple interactions

Dimercaprol inhibits the reaction [oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]]; oxophenylarsine inhibits the reaction [INS protein results in increased transport of Glucose]; oxophenylarsine inhibits the reaction [INS protein results in increased uptake of 2-(methylamino)isobutyric acid]

PMID:1928324 PMID:8048502

NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841

G

nitric oxide synthase 3

affects localization
decreases phosphorylation

oxophenylarsine affects the localization of NOS3 protein
oxophenylarsine results in decreased phosphorylation of NOS3 protein

NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943

phenylephrine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adrenoceptor alpha 1B

increases activity

Phenylephrine results in increased activity of ADRA1B protein

NCBI chr16:63,550,123...64,010,838
Ensembl chr16:63,550,130...63,603,034

G

adrenoceptor alpha 1D

increases activity

Phenylephrine results in increased activity of ADRA1D protein

NCBI chr17:31,517,021...31,537,361
Ensembl chr17:31,517,021...31,538,362

G

complement C5

affects response to substance

C5 protein affects the susceptibility to Phenylephrine

NCBI chr 1:260,995,662...261,088,868
Ensembl chr 1:260,995,668...261,133,483

phosphatidylcholine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

multiple interactions
increases export

Itraconazole inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines]; Verapamil inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines]

NCBI chr 9:93,171,371...93,262,124

G

protein disulfide isomerase family A member 3

increases hydrolysis

PDIA3 protein results in increased hydrolysis of Phosphatidylcholines

NCBI chr 1:127,786,174...127,814,096
Ensembl chr 1:127,785,772...127,814,196

physostigmine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
decreases activity

Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]
Physostigmine results in decreased activity of ACHE protein

NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,441...8,738,605

picolinic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

interleukin 6

multiple interactions

picolinic acid promotes the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

tumor necrosis factor

multiple interactions

picolinic acid inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

pioglitazone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

affects localization
increases expression

Pioglitazone affects the localization of ABCA1 protein
Pioglitazone results in increased expression of ABCA1 mRNA

NCBI chr 1:246,144,277...246,278,492
Ensembl chr 1:246,144,277...246,278,492

G

apolipoprotein A1

multiple interactions
increases secretion

Pioglitazone promotes the reaction [APOA1 protein results in increased transport of Cholesterol]
Pioglitazone results in increased secretion of APOA1 protein

NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713

G

claudin 3

multiple interactions

Pioglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN3 protein]

NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102

G

claudin 4

multiple interactions

Pioglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN4 protein]

NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925

G

lipase G, endothelial type

decreases expression

Pioglitazone results in decreased expression of LIPG mRNA; Pioglitazone results in decreased expression of LIPG protein

NCBI chr 1:99,081,940...99,110,671
Ensembl chr 1:99,081,938...99,110,874

G

mitogen-activated protein kinase 1

multiple interactions

Pioglitazone promotes the reaction [Troglitazone results in increased phosphorylation of MAPK1 protein]

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 3

multiple interactions

Pioglitazone promotes the reaction [Troglitazone results in increased phosphorylation of MAPK3 protein]

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

peroxisome proliferator activated receptor gamma

increases activity
multiple interactions

Pioglitazone results in increased activity of PPARG protein
Troglitazone inhibits the reaction [Pioglitazone results in increased activity of PPARG protein]

NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944

G

scavenger receptor class B member 1

increases expression
affects localization

Pioglitazone results in increased expression of SCARB1 mRNA
Pioglitazone affects the localization of SCARB1 protein

NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,568

putrescine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

amine oxidase copper containing 1

increases degradation

AOC1 protein results in increased degradation of Putrescine

NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974

Pyridostigmine bromide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
decreases activity

Pyridostigmine Bromide inhibits the reaction [Soman results in decreased activity of ACHE protein]
Pyridostigmine Bromide results in decreased activity of ACHE protein

NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,441...8,738,605

pyrrolidine dithiocarbamate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

C-X-C motif chemokine ligand 8

multiple interactions

pyrrolidine dithiocarbamic acid inhibits the reaction [Glyphosate results in increased expression of CXCL8 mRNA]

NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861

G

interleukin 6

multiple interactions

pyrrolidine dithiocarbamic acid inhibits the reaction [Glyphosate results in increased expression of IL6 mRNA]

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

interleukin-1 beta-like

multiple interactions

pyrrolidine dithiocarbamic acid inhibits the reaction [Glyphosate results in increased expression of IL1B mRNA]

raloxifene

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

decreases phosphorylation

Raloxifene Hydrochloride results in decreased phosphorylation of AKT1 protein

G

caveolin 1

increases expression

Raloxifene Hydrochloride results in increased expression of CAV1 protein

NCBI chr18:29,648,120...29,682,451
Ensembl chr18:29,649,992...29,682,465

G

eukaryotic translation initiation factor 4E binding protein 1

decreases phosphorylation

Raloxifene Hydrochloride results in decreased phosphorylation of EIF4EBP1 protein

NCBI chr15:48,423,001...48,443,373
Ensembl chr15:48,422,816...48,443,399

G

estrogen receptor 1

affects expression
decreases expression
affects binding

Raloxifene Hydrochloride affects the expression of ESR1 protein
Raloxifene Hydrochloride results in decreased expression of ESR1 protein alternative form
Raloxifene Hydrochloride metabolite binds to ESR1 protein

PMID:15653758 PMID:16680078 PMID:16790557 PMID:17348974

NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363

G

estrogen receptor 2

affects expression

Raloxifene Hydrochloride affects the expression of ESR2 protein

PMID:15653758 PMID:16680078

NCBI chr 1:193,823,666...193,907,330
Ensembl chr 1:193,829,560...193,906,565

G

coagulation factor III, tissue factor

affects expression

Raloxifene Hydrochloride affects the expression of F3 protein

NCBI chr 4:122,827,018...122,837,673
Ensembl chr 4:122,826,644...122,837,666

G

matrix metallopeptidase 2

affects secretion

Raloxifene Hydrochloride affects the secretion of MMP2 protein

NCBI chr 6:30,059,247...30,087,031
Ensembl chr 6:30,058,595...30,086,982

G

nitric oxide synthase 3

affects expression
decreases expression
increases phosphorylation
multiple interactions

Raloxifene Hydrochloride affects the expression of NOS3 mRNA
Raloxifene Hydrochloride results in decreased expression of NOS3 protein
Raloxifene Hydrochloride results in increased phosphorylation of NOS3 protein
Fulvestrant inhibits the reaction [Raloxifene Hydrochloride results in increased phosphorylation of NOS3 protein]

PMID:15653758 PMID:16680078 PMID:17618301

NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943

G

platelet derived growth factor subunit B

multiple interactions

Raloxifene Hydrochloride affects the secretion of [PDGFB protein binds to PDGFB protein]

Ensembl chr 5:8,986,462...9,007,435

G

selectin P

affects expression

Raloxifene Hydrochloride affects the expression of SELP protein

NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,399,955

G

TNF receptor superfamily member 11b

increases expression

Raloxifene Hydrochloride results in increased expression of TNFRSF11B protein

NCBI chr 4:19,850,212...19,879,132
Ensembl chr 4:19,850,350...19,879,125

rifampicin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 2 subfamily B member 6B

increases expression

Rifampin results in increased expression of CYP2B6B mRNA

NCBI chr 6:49,158,175...49,173,872
Ensembl chr 6:49,110,812...49,178,334

Riluzole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

citrate synthase

decreases activity

Riluzole analog results in decreased activity of CS protein

NCBI chr 5:21,669,778...21,700,737
Ensembl chr 5:21,666,585...21,700,711

G

monoamine oxidase A

decreases activity

Riluzole analog results in decreased activity of MAOA protein; Riluzole results in decreased activity of MAOA protein

NCBI chr X:38,930,452...39,006,220

G

monoamine oxidase B

decreases activity

Riluzole analog results in decreased activity of MAOB protein

NCBI chr X:39,025,973...39,144,389
Ensembl chr X:39,025,970...39,144,345

ritonavir

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nitric oxide synthase 3

decreases expression
multiple interactions

Ritonavir results in decreased expression of NOS3 mRNA; Ritonavir results in decreased expression of NOS3 protein
Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 mRNA]; Masoprocol inhibits the reaction [Ritonavir results in decreased expression of NOS3 protein]; Ritonavir results in decreased expression of and results in decreased activity of NOS3 protein

PMID:15681703 PMID:16123675 PMID:22037733

NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943

rolipram

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

adenylate cyclase activating polypeptide 1

decreases activity

Rolipram results in decreased activity of ADCYAP1 protein alternative form

NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294

ryanodine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ryanodine receptor 1

affects binding
multiple interactions

Ryanodine binds to RYR1 protein; Ryanodine binds to RYR1 protein mutant form
5'-adenylyl (beta,gamma-methylene)diphosphonate affects the reaction [Ryanodine binds to RYR1 protein]; Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]; Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein mutant form]]; Dantrolene inhibits the reaction [Caffeine promotes the reaction [Ryanodine binds to RYR1 protein]]; Dantrolene inhibits the reaction [Ryanodine binds to RYR1 protein mutant form]; Dantrolene inhibits the reaction [Ryanodine binds to RYR1 protein]; Dantrolene inhibits the reaction [Strontium promotes the reaction [Ryanodine binds to RYR1 protein]]; Strontium promotes the reaction [Ryanodine binds to RYR1 protein mutant form]; Strontium promotes the reaction [Ryanodine binds to RYR1 protein]

NCBI chr 6:47,339,759...47,458,457
Ensembl chr 6:47,343,768...47,458,458

G

ryanodine receptor 2

affects binding

Ryanodine binds to RYR2 protein

NCBI chr14:53,652,140...54,406,691
Ensembl chr14:53,652,485...54,192,063

S-adenosyl-L-methioninate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catechol-O-methyltransferase

multiple interactions

[S-Adenosylmethionine analog co-treated with COMT protein] results in increased methylation of catechol

NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998

S-butyl-DL-homocysteine (S,R)-sulfoximine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

glutamate-cysteine ligase catalytic subunit

multiple interactions
decreases activity

Buthionine Sulfoximine inhibits the reaction [sulforaphane inhibits the reaction [Cisplatin results in decreased activity of GCLC protein]]
Buthionine Sulfoximine results in decreased activity of GCLC protein

NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,565...27,253,530

S-nitrosoglutathione

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]

G

hypoxia inducible factor 1 subunit alpha

increases expression
multiple interactions

S-Nitrosoglutathione results in increased expression of HIF1A protein
2,3-dimethoxy-1,4-naphthoquinone inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; AKT1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Genistein inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]; Wortmannin inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]

NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845

G

phosphoinositide-3-kinase regulatory subunit 1

multiple interactions

PIK3R1 protein mutant form inhibits the reaction [S-Nitrosoglutathione results in increased expression of HIF1A protein]

NCBI chr16:46,434,757...46,523,626
Ensembl chr16:46,511,521...46,523,609

salubrinal

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

eukaryotic translation initiation factor 2A

increases phosphorylation

salubrinal results in increased phosphorylation of EIF2A protein

NCBI chr13:90,761,453...90,804,274
Ensembl chr13:90,761,465...90,804,274

saquinavir

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

nitric oxide synthase 3

decreases expression

Saquinavir results in decreased expression of NOS3 mRNA

NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943

SB 203580

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

AKT serine/threonine kinase 1

multiple interactions

SB 203580 affects the reaction [etoxazole affects the phosphorylation of AKT1 protein]

G

BCL2 associated X, apoptosis regulator

multiple interactions

SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX mRNA]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

BCL2 apoptosis regulator

multiple interactions

SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 mRNA]

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

caspase 3

multiple interactions

SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

chemokine (C-C motif) ligand 2

multiple interactions

SB 203580 inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]; SB 203580 inhibits the reaction [titanium dioxide results in increased expression of CCL2 mRNA]

PMID:19265715 PMID:23380242

NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026

G

claudin 1

multiple interactions

[SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of CLDN1 mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN1 mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of CLDN1 protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in decreased expression of CLDN1 mRNA]

PMID:37271275 PMID:38438008

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

interleukin 6

multiple interactions

SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 mRNA]

NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263

G

lactate dehydrogenase A

multiple interactions

SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased activity of LDHA protein]

NCBI chr 2:40,814,163...40,827,284
Ensembl chr 2:40,814,169...40,826,715

G

interleukin-1 beta-like

multiple interactions

[SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of IL1B protein]

PMID:37271275 PMID:38438008

G

mitogen-activated protein kinase 1

multiple interactions

SB 203580 inhibits the reaction [etoxazole results in increased phosphorylation of MAPK1 protein]

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 14

multiple interactions

[SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK14 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of MAPK14 mRNA]

NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031

G

mitogen-activated protein kinase 3

multiple interactions

SB 203580 inhibits the reaction [etoxazole results in increased phosphorylation of MAPK3 protein]

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

mitogen-activated protein kinase 8

multiple interactions

[SB 203580 co-treated with etoxazole] results in increased phosphorylation of MAPK8 protein

NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874

G

NLR family pyrin domain containing 3

multiple interactions

[SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA]; SB 203580 inhibits the reaction [Lipopolysaccharides results in increased expression of NLRP3 mRNA]

NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228

G

occludin

multiple interactions

[SB 203580 co-treated with theanine] inhibits the reaction [Lipopolysaccharides results in decreased expression of OCLN mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of OCLN mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of OCLN protein]; SB 203580 inhibits the reaction [Lipopolysaccharides results in decreased expression of OCLN mRNA]

PMID:37271275 PMID:38438008

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

ribosomal protein S6

multiple interactions

SB 203580 affects the reaction [etoxazole affects the phosphorylation of RPS6 protein]

NCBI chr 1:203,444,360...203,447,643
Ensembl chr 1:203,444,450...203,451,468

G

ribosomal protein S6 kinase B1

multiple interactions

SB 203580 affects the reaction [etoxazole affects the phosphorylation of RPS6KB1 protein]

NCBI chr12:36,111,584...36,159,287
Ensembl chr12:36,111,653...36,160,376

G

signal transducer and activator of transcription 1

multiple interactions

SB 203580 inhibits the reaction [Cadmium results in increased phosphorylation of STAT1 protein]

NCBI chr15:95,593,201...95,646,324
Ensembl chr15:95,593,211...95,646,260

G

signal transducer and activator of transcription 3

multiple interactions

SB 203580 inhibits the reaction [Cadmium results in increased phosphorylation of STAT3 protein]

NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992

G

tight junction protein 1

multiple interactions

SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of TJP1 mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in decreased expression of TJP1 protein]

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

tumor necrosis factor

multiple interactions

SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of TNF mRNA]; SB 203580 inhibits the reaction [Hydrogen Peroxide results in increased expression of TNF protein]

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

G

vascular cell adhesion molecule 1

multiple interactions

SB 203580 inhibits the reaction [titanium dioxide results in increased expression of VCAM1 mRNA]

NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222

serotonin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

Fos proto-oncogene, AP-1 transcription factor subunit

increases expression
multiple interactions

Serotonin results in increased expression of FOS mRNA; Serotonin results in increased expression of FOS protein
sarpogrelate inhibits the reaction [Serotonin results in increased expression of FOS mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of FOS protein]

NCBI chr 7:98,449,508...98,451,971
Ensembl chr 7:98,449,349...98,455,554

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

sarpogrelate inhibits the reaction [Serotonin results in increased expression of JUN mRNA]; sarpogrelate inhibits the reaction [Serotonin results in increased expression of JUN protein]
Serotonin results in increased expression of JUN mRNA; Serotonin results in increased expression of JUN protein

NCBI chr 6:153,686,425...153,687,635
Ensembl chr 6:153,685,682...153,687,636

G

mitogen-activated protein kinase 1

increases phosphorylation
multiple interactions

Serotonin results in increased phosphorylation of MAPK1 protein
sarpogrelate inhibits the reaction [Serotonin results in increased phosphorylation of MAPK1 protein]

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 3

multiple interactions
increases phosphorylation

sarpogrelate inhibits the reaction [Serotonin results in increased phosphorylation of MAPK3 protein]

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

sinefungin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

catechol-O-methyltransferase

decreases activity

sinefungin results in decreased activity of COMT protein

NCBI chr14:51,384,729...51,403,997
Ensembl chr14:51,385,738...51,403,998

sirolimus

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activating transcription factor 6

multiple interactions

Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of ATF6 protein]

NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304

G

BCL2 like 1

multiple interactions

Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2L1 protein]

NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694

G

beclin 1

multiple interactions

Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]

NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373

G

caspase 3

multiple interactions

Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased cleavage of CASP3 protein]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

claudin 1

multiple interactions

Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased expression of CLDN1 protein]

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

claudin 4

multiple interactions

Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in decreased expression of CLDN4 protein]

NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925

G

cytochrome c, somatic

multiple interactions

Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of CYCS protein]

NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866

G

dynactin subunit 4

multiple interactions

Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]

NCBI chr 2:151,681,001...151,713,923
Ensembl chr 2:151,681,003...151,783,746

G

DNA damage inducible transcript 3

multiple interactions

Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of DDIT3 protein]

NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829

G

endoplasmic reticulum to nucleus signaling 1

multiple interactions

Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased phosphorylation of ERN1 protein]

NCBI chr12:14,881,913...14,963,290
Ensembl chr12:14,881,923...14,963,284

G

FYVE, RhoGEF and PH domain containing 4

multiple interactions

Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]

NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028

G

fission, mitochondrial 1

multiple interactions

Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of FIS1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]

NCBI chr 3:8,938,250...8,942,102
Ensembl chr 3:8,937,453...8,946,955

G

forkhead box O1

increases expression
affects localization

Sirolimus results in increased expression of FOXO1 mRNA; Sirolimus results in increased expression of FOXO1 protein
Sirolimus affects the localization of FOXO1 protein

NCBI chr11:15,317,222...15,410,059
Ensembl chr11:15,317,124...15,410,473

G

glutathione peroxidase 1

multiple interactions

Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

H2A.X variant histone

multiple interactions

Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased expression of H2AX protein]

NCBI chr 9:46,308,824...46,310,494
Ensembl chr 9:46,309,653...46,310,084

G

heat shock protein family A (Hsp70) member 5

multiple interactions

Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in decreased expression of HSPA5 protein]

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

G

insulin like growth factor 2

decreases expression

Sirolimus results in decreased expression of IGF2 mRNA; Sirolimus results in decreased expression of IGF2 protein

NCBI chr 2:1,469,183...1,496,417

G

insulin

multiple interactions
decreases expression

Sirolimus inhibits the reaction [Glucose results in increased secretion of INS protein]
Sirolimus results in decreased expression of INS mRNA; Sirolimus results in decreased expression of INS protein

NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841

G

lysosomal associated membrane protein 2

multiple interactions

Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased expression of LAMP2 protein]

NCBI chr X:98,586,718...98,623,939
Ensembl chr X:98,581,992...98,623,940

G

microtubule associated protein 1 light chain 3 beta

multiple interactions

Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]; Sirolimus inhibits the reaction [Benzo(a)pyrene results in decreased lipidation of MAP1LC3B protein]

PMID:34811946 PMID:36754226

NCBI chr 6:1,919,879...1,941,069
Ensembl chr 6:1,915,387...1,941,069

G

mechanistic target of rapamycin kinase

multiple interactions

Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in increased phosphorylation of MTOR protein]

NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888

G

MYD88 innate immune signal transduction adaptor

multiple interactions

Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of BECN1 mRNA]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of DCTN4 mRNA]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of GPX1 mRNA]; Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of FIS1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of OPA1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of DNM1L mRNA]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in increased expression of FIS1 mRNA]]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of BECN1 protein]]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]; Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the lipidation of MAP1LC3B protein]]

NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109

G

neuronal differentiation 1

decreases expression

Sirolimus results in decreased expression of NEUROD1 mRNA

NCBI chr15:87,175,629...87,179,953
Ensembl chr15:87,175,765...87,179,959

G

occludin

multiple interactions

Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in decreased expression of OCLN protein]

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

OPA1 mitochondrial dynamin like GTPase

multiple interactions

Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat affects the expression of OPA1 protein]]; Sirolimus affects the reaction [MYD88 protein affects the reaction [Paraquat results in decreased expression of OPA1 mRNA]]

NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083

G

pancreatic and duodenal homeobox 1

decreases expression

Sirolimus results in decreased expression of PDX1 mRNA

NCBI chr11:5,303,609...5,309,063
Ensembl chr11:5,303,609...5,309,063

G

selectin P

multiple interactions

Sirolimus inhibits the reaction [Zymosan analog results in increased expression of SELP protein]

NCBI chr 4:81,376,804...81,401,240
Ensembl chr 4:81,365,740...81,399,955

G

superoxide dismutase 1

multiple interactions

Sirolimus affects the reaction [[MYD88 protein affects the susceptibility to Paraquat] which affects the expression of SOD1 mRNA]

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

sequestosome 1

multiple interactions

Sirolimus affects the reaction [Paraquat affects the reaction [MYD88 protein affects the expression of SQSTM1 protein]]

NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938

G

tight junction protein 2

multiple interactions

Sirolimus inhibits the reaction [3-acetyldeoxynivalenol results in decreased expression of TJP2 protein]

NCBI chr 1:222,474,518...222,612,989
Ensembl chr 1:222,474,639...222,612,983

G

vascular cell adhesion molecule 1

multiple interactions

Sirolimus inhibits the reaction [Zymosan analog results in increased expression of VCAM1 protein]

NCBI chr 4:117,496,914...117,511,211
Ensembl chr 4:117,496,920...117,511,222

skatole

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cytochrome P450 family 1 subfamily A member 1

increases oxidation

CYP1A1 protein results in increased oxidation of Skatole

NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775

G

cytochrome P450 family 2 subfamily A member 19

multiple interactions
increases hydroxylation

Skatole inhibits the reaction [[CYP2A19 protein results in increased hydroxylation of coumarin] which results in increased chemical synthesis of 7-hydroxycoumarin]; Skatole inhibits the reaction [CYP2A19 protein results in increased hydroxylation of coumarin]
CYP2A19 protein results in increased hydroxylation of Skatole

NCBI chr 6:49,056,579...49,064,111
Ensembl chr 6:49,056,578...49,064,107

G

cytochrome P450 family 2 subfamily E member 1

multiple interactions
increases hydroxylation

Skatole inhibits the reaction [[CYP2E1 protein results in increased hydroxylation of 4-nitrophenol] which results in increased chemical synthesis of 4-nitrocatechol]; Skatole inhibits the reaction [CYP2E1 protein results in increased hydroxylation of 4-nitrophenol]
CYP2E1 protein results in increased hydroxylation of Skatole

NCBI chr14:141,690,737...141,703,078
Ensembl chr14:141,690,426...141,736,817

G

cytochrome P450 family 2 subfamily G member 2

increases abundance
increases metabolic processing

CYP2A6 gene polymorphism results in increased abundance of Skatole
CYP2A6 protein results in increased metabolism of Skatole

PMID:10828259 PMID:15265071

NCBI chr 6:49,069,613...49,084,953

G

sulfotransferase family 2A member 1

decreases expression

Skatole results in decreased expression of SULT2A1 mRNA

NCBI chr 6:53,525,496...53,536,723
Ensembl chr 6:53,524,787...53,536,718

sodium arsenite

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

aryl hydrocarbon receptor

multiple interactions

AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of CLDN1 mRNA]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of CLDN1 protein]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of OCLN mRNA]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of OCLN protein]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of TJP1 mRNA]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of TJP1 protein]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of ARNT mRNA]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of ATG5 mRNA]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of ATG5 protein]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of BECN1 mRNA]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of CYP1A1 mRNA]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of MAP1LC3A mRNA]]; sodium arsenite promotes the reaction [deoxynivalenol affects the localization of AHR protein]; sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of AHR mRNA]

NCBI chr 9:86,511,866...86,555,950
Ensembl chr 9:86,511,369...86,555,943

G

AKT serine/threonine kinase 1

decreases expression
multiple interactions
increases degradation

sodium arsenite results in decreased expression of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of AKT1 protein]; sodium arsenite results in decreased expression of and results in increased phosphorylation of AKT1 protein; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]

PMID:12760830 PMID:16239170

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of ARNT mRNA]]; sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of ARNT mRNA]

NCBI chr 4:98,333,431...98,390,012
Ensembl chr 4:98,333,459...98,389,457

G

autophagy related 5

multiple interactions

6-formylindolo(3,2-b)carbazole promotes the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of ATG5 mRNA]]; 6-formylindolo(3,2-b)carbazole promotes the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of ATG5 protein]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of ATG5 mRNA]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of ATG5 protein]]; sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of ATG5 mRNA]; sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of ATG5 protein]

NCBI chr 1:72,343,950...72,520,402
Ensembl chr 1:72,270,799...72,520,396

G

beclin 1

multiple interactions

6-formylindolo(3,2-b)carbazole promotes the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of BECN1 mRNA]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of BECN1 mRNA]]; sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of BECN1 mRNA]

NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373

G

claudin 1

multiple interactions

6-formylindolo(3,2-b)carbazole inhibits the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of CLDN1 mRNA]]; 6-formylindolo(3,2-b)carbazole inhibits the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of CLDN1 protein]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of CLDN1 mRNA]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of CLDN1 protein]]; sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of CLDN1 mRNA]; sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of CLDN1 protein]

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

cytochrome P450 family 1 subfamily A member 1

multiple interactions

AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of CYP1A1 mRNA]]; sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of CYP1A1 mRNA]

NCBI chr 7:58,802,887...58,809,155
Ensembl chr 7:58,802,887...58,809,775

G

hypoxia inducible factor 1 subunit alpha

multiple interactions
increases expression

bisindolylmaleimide I inhibits the reaction [sodium arsenite results in increased expression of HIF1A mRNA]; Go 6976 inhibits the reaction [sodium arsenite results in increased expression of HIF1A mRNA]
sodium arsenite results in increased expression of HIF1A mRNA; sodium arsenite results in increased expression of HIF1A protein

NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845

G

microtubule associated protein 1 light chain 3 alpha

multiple interactions

6-formylindolo(3,2-b)carbazole promotes the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of MAP1LC3A mRNA]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of MAP1LC3A mRNA]]; sodium arsenite promotes the reaction [deoxynivalenol results in increased expression of MAP1LC3A mRNA]

NCBI chr17:37,957,830...37,959,505
Ensembl chr17:37,957,507...37,959,505

G

mitogen-activated protein kinase 6

increases expression

sodium arsenite results in increased expression of MAPK6 protein

NCBI chr 1:119,725,026...119,770,988
Ensembl chr 1:119,725,029...119,771,312

G

nitric oxide synthase 3

multiple interactions
increases degradation
decreases expression

2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of NOS3 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of NOS3 protein]; sodium arsenite results in increased phosphorylation of and results in decreased activity of NOS3 protein; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of NOS3 protein]
sodium arsenite results in decreased expression of NOS3 protein

NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943

G

occludin

multiple interactions

6-formylindolo(3,2-b)carbazole inhibits the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of OCLN mRNA]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of OCLN mRNA]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of OCLN protein]]; sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of OCLN mRNA]; sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of OCLN protein]

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

protein kinase cAMP-activated catalytic subunit alpha

decreases expression

sodium arsenite results in decreased expression of PRKACA protein

NCBI chr 2:65,074,876...65,095,564
Ensembl chr 2:65,074,870...65,095,551

G

protein kinase C delta

increases phosphorylation

sodium arsenite results in increased phosphorylation of PRKCD protein

NCBI chr13:35,290,835...35,323,245
Ensembl chr13:35,290,610...35,323,356

G

ribosomal protein S6 kinase A1

decreases expression

sodium arsenite results in decreased expression of RPS6KA1 protein

NCBI chr 6:83,905,124...83,947,189
Ensembl chr 6:83,905,077...83,950,963

G

superoxide dismutase 1

multiple interactions
increases activity

[sodium arsenite results in increased activity of SOD1 protein] which results in increased abundance of Hydrogen Peroxide

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

tight junction protein 1

multiple interactions

6-formylindolo(3,2-b)carbazole inhibits the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of TJP1 mRNA]]; 6-formylindolo(3,2-b)carbazole inhibits the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of TJP1 protein]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of TJP1 mRNA]]; AHR protein affects the reaction [sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of TJP1 protein]]; sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of TJP1 mRNA]; sodium arsenite promotes the reaction [deoxynivalenol results in decreased expression of TJP1 protein]

NCBI chr 1:144,930,387...145,195,857
Ensembl chr 1:144,930,370...145,195,836

G

tumor protein p53

increases expression

sodium arsenite results in increased expression of TP53

NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818

G

vascular endothelial growth factor A

increases expression
multiple interactions

sodium arsenite results in increased expression of VEGFA mRNA
bisindolylmaleimide I inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; R 59949 promotes the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; sodium arsenite results in increased expression of and results in increased secretion of VEGFA protein

NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366

Soman

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
decreases activity

Physostigmine inhibits the reaction [Soman results in decreased activity of ACHE protein]; Pyridostigmine Bromide inhibits the reaction [Soman results in decreased activity of ACHE protein]

NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,441...8,738,605

strychnine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor muscarinic 2

multiple interactions

Strychnine analog promotes the reaction [N-Methylscopolamine binds to CHRM2 protein]

NCBI chr18:12,455,139...12,600,314
Ensembl chr18:12,455,145...12,600,186

sulfamethoxazole hydroxylamine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

calreticulin

increases expression

sulfamethoxazole hydroxylamine results in increased expression of CALR protein

NCBI chr 2:66,098,263...66,102,074
Ensembl chr 2:66,098,229...66,102,132

G

heat shock protein 90 beta family member 1

decreases expression

sulfamethoxazole hydroxylamine results in decreased expression of HSP90B1 protein

NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991

G

heat shock protein family A (Hsp70) member 5

increases expression

sulfamethoxazole hydroxylamine results in increased expression of HSPA5 protein

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

sunitinib

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

gap junction protein alpha 1

decreases expression

Sunitinib results in decreased expression of GJA1 protein

NCBI chr 1:40,988,818...41,002,129
Ensembl chr 1:40,988,528...41,002,156

G

troponin T2, cardiac type

decreases expression

Sunitinib results in decreased expression of TNNT2 protein

NCBI chr10:23,749,528...23,759,696
Ensembl chr10:23,749,335...23,763,396

tacrolimus hydrate

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

increases activity

Tacrolimus results in increased activity of CASP3 protein

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

tamoxifen

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

estrogen receptor 1

affects binding

Tamoxifen metabolite binds to ESR1 protein

NCBI chr 1:14,217,032...14,604,906
Ensembl chr 1:14,217,036...14,493,363

taurine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 1, apoptosis-related cysteine peptidase

multiple interactions

Taurine inhibits the reaction [ochratoxin A results in increased expression of and results in increased cleavage of CASP1 protein]

NCBI chr 9:35,188,066...35,199,364
Ensembl chr 9:35,186,420...35,200,328

G

catalase

multiple interactions

Taurine inhibits the reaction [ochratoxin A results in decreased expression of CAT mRNA]

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

glutathione peroxidase 1

multiple interactions

Taurine inhibits the reaction [ochratoxin A results in decreased expression of GPX1 mRNA]

NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433

G

glutathione peroxidase 4

multiple interactions

Taurine inhibits the reaction [ochratoxin A results in decreased expression of GPX4 mRNA]

NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931

G

gasdermin D

multiple interactions

Taurine inhibits the reaction [ochratoxin A results in increased expression of GSDMD protein]

NCBI chr 4:995,753...1,001,964
Ensembl chr 4:995,763...1,000,271

G

interleukin-1 beta-like

multiple interactions

Taurine inhibits the reaction [ochratoxin A results in increased expression of IL1B protein]

G

NLR family pyrin domain containing 3

multiple interactions

Taurine inhibits the reaction [ochratoxin A results in increased expression of NLRP3 protein]

NCBI chr 2:56,892,241...56,977,412
Ensembl chr 2:56,892,243...56,977,228

G

nitric oxide synthase 2

multiple interactions

Taurine inhibits the reaction [ochratoxin A results in decreased expression of INOS mRNA]

NCBI chr12:44,174,944...44,219,875
Ensembl chr12:44,174,948...44,218,146

G

prostaglandin-endoperoxide synthase 2

multiple interactions

Taurine inhibits the reaction [ochratoxin A results in decreased expression of PTGS2 mRNA]

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

PYD and CARD domain containing

multiple interactions

Taurine inhibits the reaction [ochratoxin A results in increased expression of PYCARD protein]

NCBI chr 3:17,305,921...17,307,521
Ensembl chr 3:17,306,099...17,307,786

taurocholic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 11

increases transport

ABCB11 protein results in increased transport of Taurocholic Acid

NCBI chr15:75,402,296...75,487,092
Ensembl chr15:75,402,396...75,486,403

G

solute carrier organic anion transporter family member 1A2

increases uptake
multiple interactions

SLCO1A2 protein results in increased uptake of Taurocholic Acid
Amoxicillin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; cefquinome inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Clarithromycin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; daidzein inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Doxycycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; epigallocatechin gallate inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Erythromycin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Genistein inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; naringin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Oxytetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Penicillins inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Tetracycline inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; tilmicosin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]; Tylosin inhibits the reaction [SLCO1A2 protein results in increased uptake of Taurocholic Acid]

NCBI chr 5:52,020,303...52,133,132
Ensembl chr 5:52,049,443...52,129,730

tauroursodeoxycholic acid

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

activating transcription factor 4

multiple interactions

ursodoxicoltaurine inhibits the reaction [bisphenol A results in increased expression of ATF4 mRNA]; ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of ATF4 mRNA]

PMID:37207789 PMID:38845341

NCBI chr 5:8,742,964...8,745,752
Ensembl chr 5:8,742,967...8,745,368

G

activating transcription factor 6

multiple interactions

ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of ATF6 mRNA]

NCBI chr 4:88,591,279...88,806,156
Ensembl chr 4:88,591,288...88,805,304

G

BCL2 associated X, apoptosis regulator

multiple interactions

ursodoxicoltaurine inhibits the reaction [bisphenol A results in increased expression of BAX mRNA]

NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,147

G

BCL2 apoptosis regulator

multiple interactions

ursodoxicoltaurine promotes the reaction [bisphenol A results in increased expression of BCL2 mRNA]

NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879

G

caspase 3

multiple interactions

ursodoxicoltaurine inhibits the reaction [bisphenol A results in increased expression of CASP3 mRNA]

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

catalase

multiple interactions

ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of CAT mRNA]

NCBI chr 2:26,493,664...26,533,881
Ensembl chr 2:26,487,653...26,581,452

G

DNA damage inducible transcript 3

multiple interactions

ursodoxicoltaurine inhibits the reaction [bisphenol A results in increased expression of DDIT3 mRNA]; ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of DDIT3 mRNA]

PMID:37207789 PMID:38845341

NCBI chr 5:22,785,441...22,789,867
Ensembl chr 5:22,785,445...22,789,829

G

heat shock protein family A (Hsp70) member 5

multiple interactions

ursodoxicoltaurine inhibits the reaction [bisphenol A results in increased expression of HSPA5 mRNA]; ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of HSPA5 mRNA]

PMID:37207789 PMID:38845341

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

G

prostaglandin-endoperoxide synthase 1

multiple interactions

ursodoxicoltaurine inhibits the reaction [Cadmium results in decreased expression of PTGS1 mRNA]

NCBI chr 1:262,456,106...262,482,159
Ensembl chr 1:262,456,155...262,483,035

G

prostaglandin-endoperoxide synthase 2

multiple interactions

ursodoxicoltaurine inhibits the reaction [bisphenol A results in decreased expression of PTGS2 mRNA]; ursodoxicoltaurine inhibits the reaction [Cadmium results in decreased expression of PTGS2 mRNA]

PMID:37207789 PMID:38845341

NCBI chr 9:127,850,164...127,858,866
Ensembl chr 9:127,850,015...127,858,884

G

pentraxin 3

multiple interactions

ursodoxicoltaurine inhibits the reaction [bisphenol A results in decreased expression of PTX3 mRNA]; ursodoxicoltaurine inhibits the reaction [Cadmium results in decreased expression of PTX3 mRNA]

PMID:37207789 PMID:38845341

NCBI chr13:97,273,594...97,279,570
Ensembl chr13:97,273,594...97,279,569

G

superoxide dismutase 1

multiple interactions

ursodoxicoltaurine inhibits the reaction [Cadmium results in increased expression of SOD1 mRNA]

NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729

G

superoxide dismutase 2

multiple interactions

ursodoxicoltaurine affects the reaction [Cadmium results in increased expression of SOD2 mRNA]

NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,679,352...7,689,560

G

TNF alpha induced protein 6

multiple interactions

[ursodoxicoltaurine co-treated with Cadmium] results in increased expression of TNFAIP6 mRNA; ursodoxicoltaurine inhibits the reaction [Cadmium results in decreased expression of TNFAIP6 mRNA]

NCBI chr15:862,013...881,352
Ensembl chr15:862,015...881,461

G

X-box binding protein 1

multiple interactions

ursodoxicoltaurine inhibits the reaction [Cadmium results in increased splicing of XBP1 mRNA]

NCBI chr14:46,011,239...46,016,526
Ensembl chr14:46,008,377...46,016,526

tetraethylammonium

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

solute carrier family 22 member 2

increases uptake
multiple interactions

SLC22A2 protein results in increased uptake of Tetraethylammonium
Quercetin inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]; Rutin inhibits the reaction [SLC22A2 protein results in increased uptake of Tetraethylammonium]

NCBI chr 1:7,289,278...7,323,418
Ensembl chr 1:7,289,831...7,323,146

troglitazone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily A member 1

decreases expression
affects localization

Troglitazone results in decreased expression of ABCA1 mRNA
Troglitazone affects the localization of ABCA1 protein

NCBI chr 1:246,144,277...246,278,492
Ensembl chr 1:246,144,277...246,278,492

G

apolipoprotein A1

increases secretion
decreases expression
multiple interactions

Troglitazone results in increased secretion of APOA1 protein
Troglitazone results in decreased expression of APOA1 mRNA
Troglitazone promotes the reaction [APOA1 protein results in increased transport of Cholesterol]

NCBI chr 9:44,216,481...44,218,360
Ensembl chr 9:44,216,392...44,218,713

G

caspase 3

multiple interactions

[Troglitazone co-treated with beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CASP3 mRNA

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

G

CD36 molecule

multiple interactions
increases expression

T 0070907 inhibits the reaction [Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CD36 mRNA]]; Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CD36 mRNA]
Troglitazone results in increased expression of CD36 mRNA

NCBI chr 9:99,685,748...99,782,296
Ensembl chr 9:99,605,181...99,782,105

G

CCAAT enhancer binding protein alpha

multiple interactions
increases expression

Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CEBPA mRNA]
Troglitazone results in increased expression of CEBPA mRNA

PMID:11225715 PMID:30481989

NCBI chr 6:43,083,200...43,085,884
Ensembl chr 6:43,083,207...43,085,836

G

claudin 1

decreases expression

Troglitazone results in decreased expression of CLDN1 mRNA; Troglitazone results in decreased expression of CLDN1 protein

NCBI chr13:127,714,857...127,730,628
Ensembl chr13:127,712,777...127,730,657

G

claudin 3

multiple interactions
increases expression

PPARG protein affects the reaction [Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN3 protein]]; T 0070907 inhibits the reaction [Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN3 protein]]; Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN3 protein]
Troglitazone results in increased expression of CLDN3 protein

NCBI chr 3:11,019,073...11,020,102
Ensembl chr 3:11,019,073...11,020,102

G

claudin 4

increases expression
multiple interactions

Troglitazone results in increased expression of CLDN4 mRNA; Troglitazone results in increased expression of CLDN4 protein
PPARG protein affects the reaction [Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN4 protein]]; T 0070907 inhibits the reaction [Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN4 protein]]; Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN4 protein]

NCBI chr 3:11,039,711...11,053,930
Ensembl chr 3:11,039,706...11,053,925

G

catenin beta 1

multiple interactions

Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of CTNNB1 mRNA]

NCBI chr13:25,163,550...25,208,314
Ensembl chr13:25,164,277...25,208,311

G

cytochrome P450 family 17 subfamily A member 1

multiple interactions

Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 mRNA]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 protein modified form]

NCBI chr14:113,805,616...113,820,445
Ensembl chr14:113,805,611...113,812,041

G

fatty acid binding protein 4

multiple interactions

Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of FABP4 mRNA]

NCBI chr 4:55,096,400...55,101,209
Ensembl chr 4:55,096,404...55,101,896

G

insulin like growth factor 1

multiple interactions

Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of IGF1 mRNA]

NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033

G

insulin like growth factor 1 receptor

multiple interactions

Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of IGF1R mRNA]

NCBI chr 1:137,383,623...137,691,038
Ensembl chr 1:137,387,825...137,691,058

G

insulin

multiple interactions

Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Androstenedione]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Testosterone]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 mRNA]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 protein modified form]

NCBI chr 2:1,496,842...1,498,052
Ensembl chr 2:1,496,842...1,497,841

G

luteinizing hormone subunit beta

multiple interactions

Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Androstenedione]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased abundance of Testosterone]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 mRNA]; Troglitazone inhibits the reaction [[LHB protein co-treated with INS protein] results in increased expression of CYP17A1 protein modified form]

NCBI chr 6:54,263,574...54,269,286
Ensembl chr 6:54,263,576...54,271,086

G

mitogen-activated protein kinase 1

increases phosphorylation
multiple interactions

Troglitazone results in increased phosphorylation of MAPK1 protein
Pioglitazone promotes the reaction [Troglitazone results in increased phosphorylation of MAPK1 protein]

NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513

G

mitogen-activated protein kinase 3

multiple interactions
increases phosphorylation

Pioglitazone promotes the reaction [Troglitazone results in increased phosphorylation of MAPK3 protein]

NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567

G

occludin

increases expression

Troglitazone results in increased expression of OCLN mRNA

NCBI chr16:47,600,175...47,652,435
Ensembl chr16:47,600,212...47,654,033

G

peroxisome proliferator activated receptor gamma

multiple interactions
decreases expression
increases activity

[Troglitazone co-treated with deoxynivalenol] results in decreased expression of PPARG protein; bisphenol A diglycidyl ether inhibits the reaction [Troglitazone results in increased activity of PPARG protein]; PPARG protein affects the reaction [Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN3 protein]]; PPARG protein affects the reaction [Troglitazone inhibits the reaction [deoxynivalenol results in decreased expression of CLDN4 protein]]; T 0070907 inhibits the reaction [[Troglitazone co-treated with deoxynivalenol] results in decreased expression of PPARG protein]; Troglitazone inhibits the reaction [Pioglitazone results in increased activity of PPARG protein]; Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of PPARG mRNA]
Troglitazone results in decreased expression of PPARG mRNA; Troglitazone results in decreased expression of PPARG protein

PMID:14506076 PMID:17065204 PMID:30481989 PMID:36596350

NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944

G

scavenger receptor class B member 1

affects localization

Troglitazone affects the localization of SCARB1 protein

NCBI chr14:28,301,421...28,393,568
Ensembl chr14:28,301,294...28,393,568

G

secreted phosphoprotein 1

multiple interactions

Troglitazone promotes the reaction [[beta-glycerophosphoric acid co-treated with Ascorbic Acid co-treated with Dexamethasone] results in increased expression of SPP1 mRNA]

NCBI chr 8:131,077,786...131,085,334
Ensembl chr 8:131,077,786...131,085,340

G

tumor necrosis factor

multiple interactions

[Troglitazone co-treated with Zinc] inhibits the reaction [N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased activity of TNF protein]

NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,415

Tropicamide

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

cholinergic receptor muscarinic 4

multiple interactions

Tropicamide inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM4 protein]

NCBI chr 2:16,119,794...16,131,080
Ensembl chr 2:16,122,704...16,130,810

tubocurarine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

tachykinin precursor 1

affects activity

Tubocurarine affects the activity of TAC1 protein

NCBI chr 9:77,197,403...77,206,529
Ensembl chr 9:77,197,536...77,206,523

tunicamycin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

heat shock protein 90 beta family member 1

increases expression

Tunicamycin results in increased expression of HSP90B1 protein

PMID:15049342 PMID:17416481

NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991

G

heat shock protein family A (Hsp70) member 5

decreases response to substance
increases expression

HSPA5 results in decreased susceptibility to Tunicamycin
Tunicamycin results in increased expression of HSPA5 protein

PMID:15049342 PMID:16920763 PMID:17416481 PMID:17464326 PMID:18086661

NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894

Tylophorine

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

caspase 3

decreases cleavage

tylophorine results in decreased cleavage of CASP3 protein

NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213

U50488

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

multiple interactions

3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer inhibits the reaction [AGT protein results in increased secretion of Aldosterone]

NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833

G

opioid receptor kappa 1

multiple interactions

3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer inhibits the reaction [OPRK1 protein results in increased transport of Barium]

NCBI chr 4:77,399,298...77,429,025
Ensembl chr 4:77,399,183...77,426,879

urea

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

growth hormone 1

multiple interactions

GH1 protein inhibits the reaction [Lipopolysaccharides results in increased abundance of Urea]

NCBI chr12:15,064,965...15,066,698
Ensembl chr12:15,064,909...15,066,696

valsartan

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

decreases activity

Valsartan results in decreased activity of AGT protein modified form

NCBI chr14:59,643,030...59,656,835
Ensembl chr14:59,643,292...59,656,833

verapamil

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily B member 4

multiple interactions

Verapamil inhibits the reaction [ABCB4 protein results in increased export of Phosphatidylcholines]

NCBI chr 9:93,171,371...93,262,124

VX nerve agent

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

acetylcholinesterase

multiple interactions
decreases activity

N,N'-monomethylenebis(pyridiniumaldoxime) inhibits the reaction [VX-agent results in decreased activity of ACHE protein]

NCBI chr 3:8,732,451...8,738,274
Ensembl chr 3:8,732,441...8,738,605

zileuton

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

arachidonate 5-lipoxygenase

decreases activity

zileuton results in decreased activity of ALOX5 protein

NCBI chr14:90,859,209...90,907,084
Ensembl chr14:90,859,019...90,907,090

zinc protoporphyrin

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

guanylate cyclase 1 soluble subunit beta 1

multiple interactions

zinc protoporphyrin inhibits the reaction [1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one results in increased degradation of GUCY1B1 protein]

NCBI chr 8:44,544,364...44,604,690
Ensembl chr 8:44,544,179...44,604,687

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	5207
chemical entity	5206
atom	5197
main group element atom	5169
p-block element atom	5166
pnictogen	557
antimony atom +	0
arsenic atom +	24
bismuth atom +	0
moscovium atom +	0
nitrogen atom +	545
phosphorus atom +	93
pnictogen molecular entity +	557
Path 2
Term	Annotations
CHEBI ontology	5207
subatomic particle	5197
composite particle	5197
hadron	5197
baryon	5197
nucleon	5197
atomic nucleus	5197
atom	5197
main group element atom	5169
p-block element atom	5166
pnictogen	557
antimony atom +	0
arsenic atom +	24
bismuth atom +	0
moscovium atom +	0
nitrogen atom +	545
phosphorus atom +	93
pnictogen molecular entity +	557

paths to the root