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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:pnictogen
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Accession:CHEBI:33300 term browser browse the term
Definition:Any p-block element atom that is in group 15 of the periodic table: nitrogen, phosphorus, arsenic, antimony and bismuth.
Synonyms:exact_synonym: pnictogens
 related_synonym: group 15 elements;   group V elements;   nitrogenoideos;   nitrogenoides;   pnictogene;   pnictogenes


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(R)-adrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NPPA natriuretic peptide A affects abundance EXP NPPA protein affects the abundance of Epinephrine CTD PMID:2951327 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385 		JBrowse link
(R)-noradrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 increases activity EXP Norepinephrine results in increased activity of ADRB1 protein CTD PMID:10344530 NCBI chr28:24,908,224...24,909,684
Ensembl chr28:24,908,224...24,909,684 		JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP [Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine CTD PMID:2884805 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298 		JBrowse link
G NPPA natriuretic peptide A increases expression EXP Norepinephrine results in increased expression of NPPA protein CTD PMID:8952593 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma increases activity
multiple interactions		 EXP Norepinephrine results in increased activity of PIK3CG protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of PIK3CG protein]; [Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate		 CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G POMC proopiomelanocortin increases response to substance EXP POMC protein results in increased susceptibility to Norepinephrine CTD PMID:6279499 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440 		JBrowse link
G PRKCZ protein kinase C zeta increases phosphorylation
multiple interactions		 EXP Norepinephrine results in increased phosphorylation of PRKCZ protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein]		 CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
G REN renin increases activity EXP Norepinephrine results in increased activity of REN protein CTD PMID:8952593 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 multiple interactions
decreases activity		 EXP dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein] CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
1,4-phenylenediamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP8 caspase 8 increases activity
multiple interactions		 EXP 4-phenylenediamine results in increased activity of CASP8 protein
benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [4-phenylenediamine results in increased activity of CASP8 protein]		 CTD PMID:20156547 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822 		JBrowse link
G CASP9 caspase 9 multiple interactions
increases activity		 EXP benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [4-phenylenediamine results in increased activity of CASP9 protein] CTD PMID:20156547 NCBI chr 2:82,033,759...82,076,710
Ensembl chr 2:82,031,563...82,090,484 		JBrowse link
1-stearoyl-2-arachidonoylphosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP 1-stearoyl-2-arachidonoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
2-(3,4-dimethoxyphenyl)-5-\{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino\}-2-(propan-2-yl)pentanenitrile term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP [Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin CTD PMID:20510202 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
3',5'-cyclic AMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions EXP [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059 		JBrowse link
3'-CMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions EXP [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate CTD PMID:2579070 NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653 		JBrowse link
3-isobutyl-1-methyl-7H-xanthine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator multiple interactions EXP [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein CTD PMID:15161604 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977 		JBrowse link
4-amino-5-chloro-N-[1-[3-(4-fluorophenoxy)propyl]-3-methoxy-4-piperidinyl]-2-methoxybenzamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions EXP Cisapride binds to and results in decreased activity of KCNH2 protein CTD PMID:12388285 NCBI chr16:15,009,031...15,041,786
Ensembl chr16:15,009,031...15,041,504 		JBrowse link
4-nitrophenyl phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPI alkaline phosphatase, intestinal increases chemical synthesis EXP ALPI protein results in increased chemical synthesis of nitrophenylphosphate CTD PMID:1495895 NCBI chr25:44,107,418...44,110,947 JBrowse link
5'-phosphopyridoxal-6-azobenzene-2,4-disulfonic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 multiple interactions EXP pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP] CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059 		JBrowse link
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Omeprazole results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
G SLC22A6 solute carrier family 22 member 6 multiple interactions EXP [Omeprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr18:53,736,669...53,745,001
Ensembl chr18:53,736,959...53,744,396 		JBrowse link
5-Nitro-2-(3-phenylpropylamino)benzoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator decreases activity EXP 5-nitro-2-(3-phenylpropylamino)benzoic acid results in decreased activity of CFTR protein CTD PMID:15496164 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977 		JBrowse link
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity EXP 6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein mutant form CTD PMID:21778469 NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827 		JBrowse link
7,9-dihydro-1H-purine-2,6,8(3H)-trione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP6V0D1 ATPase H+ transporting V0 subunit d1 increases expression EXP Uric Acid results in increased expression of ATP6V0D1 protein CTD PMID:32991862 NCBI chr 5:81,926,589...81,965,959
Ensembl chr 5:81,926,612...81,965,526 		JBrowse link
G DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 increases expression EXP Uric Acid results in increased expression of DNAJC3 protein CTD PMID:32991862 NCBI chr22:46,323,263...46,402,240
Ensembl chr22:46,307,905...46,398,625 		JBrowse link
G EEF2 eukaryotic translation elongation factor 2 decreases expression EXP Uric Acid results in decreased expression of EEF2 protein CTD PMID:32991862 NCBI chr20:55,577,413...55,586,422
Ensembl chr20:55,522,213...55,586,126 		JBrowse link
G EZR ezrin increases expression EXP Uric Acid results in increased expression of EZR protein CTD PMID:32991862 NCBI chr 1:48,160,206...48,210,036
Ensembl chr 1:48,160,206...48,210,036 		JBrowse link
G HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 increases expression EXP Uric Acid results in increased expression of HNRNPA2B1 protein CTD PMID:32991862 NCBI chr14:39,498,805...39,509,034
Ensembl chr14:39,500,897...39,508,952 		JBrowse link
G HSP90AA1 heat shock protein 90 alpha family class A member 1 increases expression EXP Uric Acid results in increased expression of HSP90AA1 protein CTD PMID:32991862 NCBI chr 8:70,091,203...70,096,107
Ensembl chr 8:70,092,217...70,095,243 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Uric Acid results in increased expression of HSPA5 protein CTD PMID:32991862 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257 		JBrowse link
G HSPD1 heat shock protein family D (Hsp60) member 1 decreases expression EXP Uric Acid results in decreased expression of HSPD1 protein CTD PMID:32991862 NCBI chr37:7,010,421...7,025,912 JBrowse link
G IMMT inner membrane mitochondrial protein increases expression EXP Uric Acid results in increased expression of IMMT protein CTD PMID:32991862 NCBI chr17:38,927,508...38,964,522
Ensembl chr17:38,927,531...38,967,004 		JBrowse link
G LOC102151342 ATP synthase subunit d, mitochondrial-like increases expression EXP Uric Acid results in increased expression of ATP5PD protein CTD PMID:32991862 NCBI chr 7:66,856,651...66,857,162 JBrowse link
G MDH2 malate dehydrogenase 2 decreases expression EXP Uric Acid results in decreased expression of MDH2 protein CTD PMID:32991862 NCBI chr 6:7,389,266...7,405,311 JBrowse link
G NAPA NSF attachment protein alpha decreases expression EXP Uric Acid results in decreased expression of NAPA protein CTD PMID:32991862 NCBI chr 1:108,510,920...108,533,317
Ensembl chr 1:108,510,931...108,532,881 		JBrowse link
G OAT ornithine aminotransferase increases expression EXP Uric Acid results in increased expression of OAT protein CTD PMID:32991862 NCBI chr28:33,763,661...33,788,817
Ensembl chr28:33,758,473...33,788,759 		JBrowse link
G PC pyruvate carboxylase decreases expression EXP Uric Acid results in decreased expression of PC protein CTD PMID:32991862 NCBI chr18:50,406,994...50,507,677
Ensembl chr18:50,412,272...50,507,669 		JBrowse link
G RAB11A RAB11A, member RAS oncogene family decreases expression EXP Uric Acid results in decreased expression of RAB11A protein CTD PMID:32991862 NCBI chr30:30,200,831...30,218,412
Ensembl chr30:30,200,831...30,218,411 		JBrowse link
G SAE1 SUMO1 activating enzyme subunit 1 decreases expression EXP Uric Acid results in decreased expression of SAE1 protein CTD PMID:32991862 NCBI chr 1:108,757,543...108,864,763
Ensembl chr 1:108,749,061...108,859,797 		JBrowse link
G SLC25A12 solute carrier family 25 member 12 decreases expression EXP Uric Acid results in decreased expression of SLC25A12 protein CTD PMID:32991862 NCBI chr36:16,185,011...16,391,080
Ensembl chr36:16,185,649...16,483,016 		JBrowse link
G SLC2A9 solute carrier family 2 member 9 increases transport EXP SLC2A9 protein results in increased transport of Uric Acid CTD PMID:18989453 NCBI chr 3:69,394,304...69,588,462
Ensembl chr 3:69,394,152...69,595,802 		JBrowse link
8-(4-chlorophenylthio)-cAMP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator multiple interactions EXP [1-Methyl-3-isobutylxanthine co-treated with 8-((4-chlorophenyl)thio)cyclic-3',5'-AMP] results in increased activity of CFTR protein CTD PMID:15161604 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977 		JBrowse link
acetylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766 		JBrowse link
G KCNJ6 potassium inwardly rectifying channel subfamily J member 6 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478 		JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions EXP Acetylcholine results in increased phosphorylation of and results in increased activity of MAPK14 protein CTD PMID:9688607 NCBI chr12:5,145,647...5,221,558
Ensembl chr12:5,146,037...5,220,603 		JBrowse link
acyclovir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AVP arginine vasopressin decreases activity EXP Acyclovir results in decreased activity of AVP protein CTD PMID:2724137 NCBI chr24:18,183,057...18,184,827
Ensembl chr24:18,183,057...18,184,883 		JBrowse link
amiodarone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC8A1 solute carrier family 8 member A1 decreases activity EXP Amiodarone results in decreased activity of SLC8A1 protein CTD PMID:15288574 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700 		JBrowse link
amlodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin increases expression EXP Amlodipine results in increased expression of REN protein CTD PMID:10218729 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
amosulalol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 multiple interactions EXP amosulalol binds to and results in decreased activity of ADRB1 protein CTD PMID:6129981 NCBI chr28:24,908,224...24,909,684
Ensembl chr28:24,908,224...24,909,684 		JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP amosulalol binds to and results in decreased activity of ADRB2 protein CTD PMID:6129981 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298 		JBrowse link
anthra[1,9-cd]pyrazol-6(2H)-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions EXP pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]] CTD PMID:23816505 NCBI chr 5:50,966,698...50,968,939 JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP pyrazolanthrone inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119 		JBrowse link
G SP1 Sp1 transcription factor multiple interactions EXP pyrazolanthrone inhibits the reaction [Sodium Chloride promotes the reaction [SP1 protein binds to JUN protein]]; pyrazolanthrone inhibits the reaction [Sodium Chloride results in increased expression of SP1 protein] CTD PMID:23816505 NCBI chr27:1,802,587...1,861,187
Ensembl chr27:1,805,184...1,847,226 		JBrowse link
antipyrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Antipyrine results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
arsane term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP Arsenic results in increased phosphorylation of MAPK1 protein CTD PMID:29306782 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP Arsenic results in increased phosphorylation of MAPK3 protein CTD PMID:29306782 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
arsenic atom term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 increases phosphorylation EXP Arsenic results in increased phosphorylation of MAPK1 protein CTD PMID:29306782 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases phosphorylation EXP Arsenic results in increased phosphorylation of MAPK3 protein CTD PMID:29306782 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
arsenite(3-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSP70 heat shock protein 70 increases expression
multiple interactions		 EXP arsenite results in increased expression of HSP70 mRNA
HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]]		 CTD PMID:32899721 NCBI chr12:1,285,282...1,287,670 JBrowse link
G IL1B interleukin 1 beta multiple interactions EXP arsenite affects the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]] CTD PMID:32899721 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]] CTD PMID:32899721 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions EXP arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]] CTD PMID:32899721 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; HSP70 protein affects the reaction [arsenite inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]] CTD PMID:32899721 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
arsenous acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:23236503 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:23236503 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G SLC9A1 solute carrier family 9 member A1 increases expression EXP Arsenic Trioxide results in increased expression of SLC9A1 protein CTD PMID:23236503 NCBI chr 2:73,054,742...73,103,364
Ensembl chr 2:73,054,742...73,103,364 		JBrowse link
astemizole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions EXP Astemizole binds to and results in decreased activity of KCNH2 protein CTD PMID:12388285 NCBI chr16:15,009,031...15,041,786
Ensembl chr16:15,009,031...15,041,504 		JBrowse link
atenolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin multiple interactions EXP Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] CTD PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX-agent results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702 		JBrowse link
G SCT secretin multiple interactions EXP Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates] CTD PMID:3562434
Azaspiracid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDH1 cadherin 1 decreases uptake EXP azaspiracid results in decreased uptake of CDH1 protein modified form CTD PMID:20547569 NCBI chr 5:80,757,508...80,834,878
Ensembl chr 5:80,757,508...80,834,878 		JBrowse link
benazepril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DES desmin decreases expression EXP benazepril results in decreased expression of DES mRNA CTD PMID:20137276 NCBI chr37:25,933,525...25,939,910
Ensembl chr37:25,933,455...25,940,985 		JBrowse link
blebbistatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB11 ATP binding cassette subfamily B member 11 decreases localization EXP blebbistatin results in decreased localization of ABCB11 protein CTD PMID:15826951 NCBI chr36:13,742,895...13,835,312
Ensembl chr36:13,746,964...13,834,974 		JBrowse link
Butyrylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase increases hydrolysis
multiple interactions		 EXP BCHE protein results in increased hydrolysis of butyrylcholine
Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]		 CTD PMID:4631366 PMID:4985882 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583 		JBrowse link
butyrylthiocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase increases hydrolysis EXP BCHE protein results in increased hydrolysis of Butyrylthiocholine CTD PMID:22407886 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583 		JBrowse link
capsaicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HTR1B 5-hydroxytryptamine receptor 1B multiple interactions EXP HTR1B protein promotes the reaction [donitriptan results in decreased susceptibility to Capsaicin] CTD PMID:16880765 NCBI chr12:38,659,088...38,659,546 JBrowse link
G TRPV1 transient receptor potential cation channel subfamily V member 1 multiple interactions
increases activity		 EXP JYL 1421 inhibits the reaction [Capsaicin results in increased activity of TRPV1 protein] CTD PMID:17392452 NCBI chr 9:47,404,987...47,443,871
Ensembl chr 9:47,404,972...47,431,926 		JBrowse link
carmustine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MGMT O-6-methylguanine-DNA methyltransferase decreases response to substance
multiple interactions		 EXP MGMT protein mutant form results in decreased susceptibility to Carmustine; MGMT protein results in decreased susceptibility to Carmustine
MGMT protein mutant form results in decreased susceptibility to [Carmustine co-treated with O(6)-benzylguanine]		 CTD PMID:14617759 PMID:15053863 NCBI chr28:38,204,611...38,427,482
Ensembl chr28:38,204,610...38,427,380 		JBrowse link
carprofen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP carprofen results in decreased expression of PTGS2 mRNA CTD PMID:15198222 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903 		JBrowse link
carvedilol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 decreases activity EXP Carvedilol results in decreased activity of CASP3 protein CTD PMID:12875697 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505 		JBrowse link
G FAS Fas cell surface death receptor decreases expression EXP Carvedilol results in decreased expression of FAS CTD PMID:12875697 NCBI chr26:38,738,811...38,763,298
Ensembl chr26:38,737,611...38,763,321 		JBrowse link
G FASLG Fas ligand decreases expression EXP Carvedilol results in decreased expression of FASLG CTD PMID:12875697 NCBI chr 7:26,335,837...26,344,224
Ensembl chr 7:26,335,846...26,344,224 		JBrowse link
G NT5E 5'-nucleotidase ecto increases activity EXP Carvedilol results in increased activity of NT5E protein CTD PMID:15148268 NCBI chr12:45,491,028...45,520,019
Ensembl chr12:45,491,733...45,518,405 		JBrowse link
G RYR2 ryanodine receptor 2 multiple interactions EXP Carvedilol results in decreased oxidation of and results in increased stability of RYR2 protein CTD PMID:17448375 NCBI chr 4:2,371,868...2,908,132
Ensembl chr 4:2,373,114...2,907,875 		JBrowse link
Ceronapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACE angiotensin I converting enzyme decreases activity EXP ceronapril results in decreased activity of ACE protein CTD PMID:1812274 NCBI chr 9:11,497,182...11,516,362
Ensembl chr 9:11,497,182...11,516,358 		JBrowse link
ceruletide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SCT secretin multiple interactions EXP [Ceruletide co-treated with SCT protein] results in increased abundance of Bicarbonates CTD PMID:3562434
cilazapril monohydrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen decreases expression EXP Cilazapril results in decreased expression of AGT protein CTD PMID:2419701 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G REN renin increases activity EXP Cilazapril results in increased activity of REN protein CTD PMID:2419701 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
cilostazol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MYC MYC proto-oncogene, bHLH transcription factor decreases expression EXP Cilostazol results in decreased expression of MYC mRNA CTD PMID:19545562 NCBI chr13:25,200,772...25,205,309
Ensembl chr13:25,200,577...25,205,309 		JBrowse link
cimetidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A2 solute carrier family 22 member 2 decreases activity EXP Cimetidine results in decreased activity of SLC22A2 protein CTD PMID:36669674 NCBI chr 1:49,327,621...49,348,435
Ensembl chr 1:49,327,296...49,348,435 		JBrowse link
cisapride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNH2 potassium voltage-gated channel subfamily H member 2 multiple interactions EXP Cisapride binds to and results in decreased activity of KCNH2 protein CTD PMID:12388285 NCBI chr16:15,009,031...15,041,786
Ensembl chr16:15,009,031...15,041,504 		JBrowse link
clonidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A increases response to substance
multiple interactions		 EXP ADRA2A protein results in increased susceptibility to Clonidine
Clonidine binds to and results in increased activity of ADRA2A protein		 CTD PMID:16814767 NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684 		JBrowse link
G ADRA2C adrenoceptor alpha 2C increases response to substance EXP ADRA2C protein results in increased susceptibility to Clonidine CTD PMID:16814767 NCBI chr 3:60,608,632...60,648,112
Ensembl chr 3:60,646,132...60,647,722 		JBrowse link
G GH1 growth hormone increases secretion EXP Clonidine results in increased secretion of GH1 protein CTD PMID:6248808 NCBI chr 9:11,832,265...11,834,123
Ensembl chr 9:11,832,265...11,834,123 		JBrowse link
G NISCH nischarin multiple interactions
affects binding		 EXP Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein] CTD PMID:24120658 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions
increases activity		 EXP [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
G REN renin multiple interactions
decreases activity		 EXP Clonidine results in decreased secretion of and results in decreased activity of REN protein
Clonidine results in decreased activity of REN protein		 CTD PMID:6248808 PMID:6991409 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
clonidine (amino form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A multiple interactions
increases response to substance		 EXP Clonidine binds to and results in increased activity of ADRA2A protein
ADRA2A protein results in increased susceptibility to Clonidine		 CTD PMID:16814767 NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684 		JBrowse link
G ADRA2C adrenoceptor alpha 2C increases response to substance EXP ADRA2C protein results in increased susceptibility to Clonidine CTD PMID:16814767 NCBI chr 3:60,608,632...60,648,112
Ensembl chr 3:60,646,132...60,647,722 		JBrowse link
G GH1 growth hormone increases secretion EXP Clonidine results in increased secretion of GH1 protein CTD PMID:6248808 NCBI chr 9:11,832,265...11,834,123
Ensembl chr 9:11,832,265...11,834,123 		JBrowse link
G NISCH nischarin affects binding
multiple interactions		 EXP Clonidine binds to NISCH protein
Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein]		 CTD PMID:24120658 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma increases activity
multiple interactions		 EXP Clonidine results in increased activity of PIK3CG protein
[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein]		 CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
G REN renin multiple interactions
decreases activity		 EXP Clonidine results in decreased secretion of and results in decreased activity of REN protein
Clonidine results in decreased activity of REN protein		 CTD PMID:6248808 PMID:6991409 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
clonidine (imino form) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA2A adrenoceptor alpha 2A multiple interactions
increases response to substance		 EXP Clonidine binds to and results in increased activity of ADRA2A protein
ADRA2A protein results in increased susceptibility to Clonidine		 CTD PMID:16814767 NCBI chr28:22,366,989...22,392,163
Ensembl chr28:22,367,780...22,370,684 		JBrowse link
G ADRA2C adrenoceptor alpha 2C increases response to substance EXP ADRA2C protein results in increased susceptibility to Clonidine CTD PMID:16814767 NCBI chr 3:60,608,632...60,648,112
Ensembl chr 3:60,646,132...60,647,722 		JBrowse link
G GH1 growth hormone increases secretion EXP Clonidine results in increased secretion of GH1 protein CTD PMID:6248808 NCBI chr 9:11,832,265...11,834,123
Ensembl chr 9:11,832,265...11,834,123 		JBrowse link
G NISCH nischarin multiple interactions
affects binding		 EXP Guanine Nucleotides inhibits the reaction [Clonidine binds to NISCH protein] CTD PMID:24120658 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636 		JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions
increases activity		 EXP [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
G REN renin decreases activity
multiple interactions		 EXP Clonidine results in decreased activity of REN protein
Clonidine results in decreased secretion of and results in decreased activity of REN protein		 CTD PMID:6248808 PMID:6991409 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
clotrimazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Clotrimazole results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
G NR1I3 nuclear receptor subfamily 1 group I member 3 affects binding
increases activity		 EXP Clotrimazole binds to NR1I3 protein
Clotrimazole results in increased activity of NR1I3 protein; Clotrimazole results in increased activity of NR1I3 protein mutant form		 CTD PMID:21778469 PMID:27732639 NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827 		JBrowse link
corticotropin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin increases abundance EXP INS protein results in increased abundance of Adrenocorticotropic Hormone CTD PMID:1646414 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
cyclophosphamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6 cytochrome P450 2B11 increases hydroxylation EXP CYP2B6 protein results in increased hydroxylation of Cyclophosphamide CTD PMID:16546968 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293 		JBrowse link
cytidine 5'-monophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase multiple interactions EXP [delta-hexachlorocyclohexane results in decreased activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Hexachlorocyclohexane affects the activity of CDIPT protein] which results in decreased abundance of Cytidine Monophosphate; [Inositol promotes the reaction [CDIPT protein results in increased metabolism of Cytidine Diphosphate Diglycerides]] which results in increased abundance of Cytidine Monophosphate CTD PMID:2579070 NCBI chr 6:17,910,141...17,914,573
Ensembl chr 6:17,910,192...17,914,653 		JBrowse link
desferrioxamine B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions EXP Deferoxamine inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin] CTD PMID:8021468 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
desipramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2D15 cytochrome P450 family 2 subfamily D member 15 affects metabolic processing EXP CYP2D15 affects the metabolism of Desipramine CTD PMID:7786018 NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298 		JBrowse link
dexmedetomidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NISCH nischarin affects activity EXP Dexmedetomidine affects the activity of NISCH CTD PMID:7486159 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636 		JBrowse link
dextromethorphan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6 cytochrome P450 2B11 increases metabolic processing EXP CYP2B6 protein results in increased metabolism of Dextromethorphan CTD PMID:12637241 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293 		JBrowse link
G CYP2D15 cytochrome P450 family 2 subfamily D member 15 affects metabolic processing EXP CYP2D15 affects the metabolism of Dextromethorphan CTD PMID:7786018 NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298 		JBrowse link
diarsenic trioxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK1 protein CTD PMID:23236503 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Arsenic Trioxide results in increased phosphorylation of and results in increased activity of MAPK3 protein CTD PMID:23236503 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G SLC9A1 solute carrier family 9 member A1 increases expression EXP Arsenic Trioxide results in increased expression of SLC9A1 protein CTD PMID:23236503 NCBI chr 2:73,054,742...73,103,364
Ensembl chr 2:73,054,742...73,103,364 		JBrowse link
diazepam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C18 cytochrome P450 2C21 affects metabolic processing EXP CYP2C19 protein affects the metabolism of Diazepam CTD PMID:15801540 NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587 		JBrowse link
G CYP3A12 cytochrome P-450 3A12 multiple interactions
increases hydroxylation		 EXP Ketoconazole inhibits the reaction [CYP3A12 protein results in increased hydroxylation of Diazepam] CTD PMID:15677349
dichlorvos term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase decreases activity EXP Dichlorvos results in decreased activity of ACHE protein CTD PMID:89824 PMID:3627083 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702 		JBrowse link
G BCHE butyrylcholinesterase decreases activity EXP Dichlorvos results in decreased activity of BCHE protein CTD PMID:3627083 PMID:4631366 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583 		JBrowse link
diclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C18 cytochrome P450 2C21 increases hydroxylation EXP CYP2C19 protein results in increased hydroxylation of Diclofenac CTD PMID:15677349 NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587 		JBrowse link
G CYP2C41 cytochrome P450 2C41 affects metabolic processing EXP CYP2C9 protein affects the metabolism of Diclofenac CTD PMID:15801540
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Diclofenac results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
diethyldithiocarbamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions EXP Ditiocarb inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene] CTD PMID:8592870 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754 		JBrowse link
dihexadecanoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity
multiple interactions		 EXP dipalmitoylphosphatidic acid results in increased activity of PLCG1 protein
dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]		 CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
diisopropyl fluorophosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase decreases activity EXP Isoflurophate results in decreased activity of BCHE protein CTD PMID:4631366 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583 		JBrowse link
dimyristoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP dimyristoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
dioleoyl phosphatidic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 increases activity EXP dioleoylphosphatidic acid results in increased activity of PLCG1 protein CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714 		JBrowse link
DPDPE term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B2 solute carrier organic anion transporter family member 1B2 increases transport EXP SLCO1B3 protein results in increased transport of Enkephalin, D-Penicillamine (2,5)- CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989 		JBrowse link
edaravone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SELP selectin P decreases expression EXP Edaravone results in decreased expression of SELP protein CTD PMID:16041266 NCBI chr 7:28,956,428...28,997,266
Ensembl chr 7:28,958,486...28,996,313 		JBrowse link
emodepside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects response to substance EXP ABCB1 protein affects the susceptibility to emodepside CTD PMID:25660379 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
enalapril term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of ATP2A2 protein CTD PMID:18820026 NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388 		JBrowse link
G EGR1 early growth response 1 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of EGR1 protein CTD PMID:18820026 NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575 		JBrowse link
G GATA4 GATA binding protein 4 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein CTD PMID:18820026 NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989 		JBrowse link
G KCND3 potassium voltage-gated channel subfamily D member 3 decreases expression EXP Enalapril results in decreased expression of KCND3 mRNA CTD PMID:19732978 NCBI chr17:63,470,829...63,668,354
Ensembl chr17:63,470,415...63,668,035 		JBrowse link
G NAB1 NGFI-A binding protein 1 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of NAB1 protein CTD PMID:18820026 NCBI chr37:1,207,619...1,243,546
Ensembl chr37:1,207,638...1,241,610 		JBrowse link
G NOS3 nitric oxide synthase 3 increases expression
multiple interactions		 EXP Enalapril results in increased expression of NOS3 mRNA
FR 173657 inhibits the reaction [Enalapril results in increased expression of NOS3 mRNA]		 CTD PMID:12019275 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277 		JBrowse link
G NPPA natriuretic peptide A multiple interactions
decreases expression		 EXP FR 173657 inhibits the reaction [Enalapril results in decreased expression of NPPA protein] CTD PMID:12019275 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385 		JBrowse link
G REN renin increases activity
multiple interactions		 EXP Enalapril results in increased activity of REN protein
[Enalapril co-treated with FR 173657] results in increased activity of REN protein		 CTD PMID:12019275 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
G SLC8A1 solute carrier family 8 member A1 multiple interactions EXP [Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein CTD PMID:18820026 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700 		JBrowse link
felodipine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Felodipine results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
fenfluramine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EDN1 endothelin 1 increases activity EXP Fenfluramine results in increased activity of EDN1 protein CTD PMID:9918753 NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383 		JBrowse link
flufenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 hydrogenase/reductase 4 decreases activity EXP Flufenamic Acid results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
fomepizole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 multiple interactions EXP Fomepizole inhibits the reaction [CYP2E1 protein affects the metabolism of Toluene] CTD PMID:8592870 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754 		JBrowse link
ganglioside GM1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNAQ G protein subunit alpha q multiple interactions EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein] CTD PMID:21671308 NCBI chr 1:80,733,530...80,928,065
Ensembl chr 1:80,715,366...80,928,065 		JBrowse link
G HEXB hexosaminidase subunit beta multiple interactions EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; G(M1) Ganglioside inhibits the reaction [Melitten results in increased secretion of HEXB protein]; G(M1) Ganglioside inhibits the reaction [Wasp Venoms results in increased secretion of HEXB protein] CTD PMID:21334356 PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417 		JBrowse link
glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] CTD PMID:23816505 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:23816505 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119 		JBrowse link
glyburide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator decreases activity EXP Glyburide results in decreased activity of CFTR protein CTD PMID:15496164 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977 		JBrowse link
hexaconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC47A1 solute carrier family 47 member 1 decreases activity EXP hexaconazole results in decreased activity of SLC47A1 protein CTD PMID:36669674 NCBI chr 5:40,643,420...40,679,130
Ensembl chr 5:40,642,784...40,679,946 		JBrowse link
G SLC47A2 solute carrier family 47 member 2 decreases activity EXP hexaconazole results in decreased activity of SLC47A2 protein CTD PMID:36669674 NCBI chr 5:40,491,306...40,515,430
Ensembl chr 5:40,491,933...40,540,136 		JBrowse link
idazoxan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NISCH nischarin multiple interactions EXP Idazoxan binds to and results in decreased activity of NISCH protein CTD PMID:8732285 NCBI chr20:37,278,660...37,312,549
Ensembl chr20:37,279,282...37,312,636 		JBrowse link
imidazoles term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I3 nuclear receptor subfamily 1 group I member 3 decreases activity
multiple interactions		 EXP Imidazoles results in decreased activity of NR1I3 protein alternative form
artemisinin inhibits the reaction [Imidazoles results in decreased activity of NR1I3 protein alternative form]; Imidazoles inhibits the reaction [artemisinin results in increased activity of NR1I3 protein mutant form]		 CTD PMID:21778469 NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827 		JBrowse link
indometacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions EXP Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Indomethacin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
indoxyl sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A6 solute carrier family 22 member 6 multiple interactions EXP [Lansoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican; [Omeprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican; [Pantoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr18:53,736,669...53,745,001
Ensembl chr18:53,736,959...53,744,396 		JBrowse link
iprodione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP [iprodione binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866 		JBrowse link
isatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DHRS4 hydrogenase/reductase 4 increases reduction EXP DHRS4 protein results in increased reduction of Isatin CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
isoprenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin multiple interactions
increases activity		 EXP Atenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; Pindolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]; xibenolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] CTD PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
ketoconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 decreases expression
decreases activity
multiple interactions		 EXP Ketoconazole results in decreased expression of ABCB1 mRNA
Ketoconazole results in decreased activity of ABCB1 protein
[Ketoconazole results in decreased activity of ABCB1 protein] which results in decreased transport of Technetium Tc 99m Sestamibi		 CTD PMID:19754906 PMID:22620706 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G CYP3A12 cytochrome P-450 3A12 decreases activity
multiple interactions		 EXP Ketoconazole results in decreased activity of CYP3A12 protein
Ketoconazole inhibits the reaction [CYP3A12 protein results in increased hydroxylation of Diazepam]		 CTD PMID:15677349
lansoprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A6 solute carrier family 22 member 6 multiple interactions EXP [Lansoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr18:53,736,669...53,745,001
Ensembl chr18:53,736,959...53,744,396 		JBrowse link
loperamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects response to substance
increases export		 EXP ABCB1 protein affects the susceptibility to Loperamide
ABCB1 protein results in increased export of Loperamide		 CTD PMID:25660379 PMID:28093773 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
loratadine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity EXP Loratadine results in increased activity of CASP3 protein CTD PMID:20570632 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505 		JBrowse link
losartan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin increases expression EXP Losartan results in increased expression of REN protein CTD PMID:10483973 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
losartan carboxylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin increases expression EXP losartan carboxylic acid results in increased expression of REN protein CTD PMID:10483973 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
LY294002 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of PIK3CG protein] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G PRKCZ protein kinase C zeta multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
marbofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP8 caspase 8 increases expression
multiple interactions		 EXP marbofloxacin results in increased expression of CASP8 mRNA
TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of CASP8 mRNA]		 CTD PMID:31005593 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822 		JBrowse link
G FADD Fas associated via death domain increases expression EXP marbofloxacin results in increased expression of FADD mRNA CTD PMID:31005593 NCBI chr18:48,087,447...48,094,497 JBrowse link
G TNF tumor necrosis factor increases expression EXP marbofloxacin results in increased expression of TNF mRNA; marbofloxacin results in increased expression of TNF protein CTD PMID:31005593 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A multiple interactions
increases expression		 EXP TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of CASP8 mRNA]; TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of TRADD mRNA]
marbofloxacin results in increased expression of TNFRSF1A mRNA; marbofloxacin results in increased expression of TNFRSF1A protein		 CTD PMID:31005593 NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282 		JBrowse link
G TRADD TNFRSF1A associated via death domain increases expression
multiple interactions		 EXP marbofloxacin results in increased expression of TRADD mRNA
TNFRSF1A mRNA promotes the reaction [marbofloxacin results in increased expression of TRADD mRNA]		 CTD PMID:31005593 NCBI chr 5:82,200,430...82,211,430
Ensembl chr 5:82,206,111...82,210,963 		JBrowse link
masitinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCA5 ATP binding cassette subfamily A member 5 increases expression EXP masitinib results in increased expression of ABCA5 mRNA CTD PMID:22747577 NCBI chr 9:15,708,070...15,781,100
Ensembl chr 9:15,420,835...15,783,045 		JBrowse link
G ABHD14A abhydrolase domain containing 14A increases expression EXP masitinib results in increased expression of ABHD14A mRNA CTD PMID:22747577 NCBI chr20:37,738,500...37,744,689 JBrowse link
G ABITRAM actin binding transcription modulator decreases expression EXP masitinib results in decreased expression of ABITRAM mRNA CTD PMID:22747577 NCBI chr11:64,094,653...64,100,078
Ensembl chr11:64,094,721...64,109,421 		JBrowse link
G ABLIM1 actin binding LIM protein 1 increases expression EXP masitinib results in increased expression of ABLIM1 mRNA CTD PMID:22747577 NCBI chr28:25,260,323...25,543,369
Ensembl chr28:25,260,873...25,545,304 		JBrowse link
G ACAT2 acetyl-CoA acetyltransferase 2 decreases expression EXP masitinib results in decreased expression of ACAT2 mRNA CTD PMID:22747577 NCBI chr 1:49,011,665...49,029,368
Ensembl chr 1:49,011,706...49,029,327 		JBrowse link
G ACSM3 acyl-CoA synthetase medium chain family member 3 increases expression EXP masitinib results in increased expression of ACSM3 mRNA CTD PMID:22747577 NCBI chr 6:24,558,010...24,594,326
Ensembl chr 6:24,558,142...24,582,728 		JBrowse link
G ACTL7A actin like 7A increases expression EXP masitinib results in increased expression of ACTL7A mRNA CTD PMID:22747577 NCBI chr11:64,031,305...64,033,908
Ensembl chr11:64,032,358...64,033,788 		JBrowse link
G ACTR2 actin related protein 2 decreases expression EXP masitinib results in decreased expression of ACTR2 protein CTD PMID:22747577 NCBI chr10:64,696,068...64,733,027
Ensembl chr10:64,696,111...64,730,553 		JBrowse link
G ADPRH ADP-ribosylarginine hydrolase increases expression EXP masitinib results in increased expression of ADPRH mRNA CTD PMID:22747577 NCBI chr33:23,218,633...23,226,844
Ensembl chr33:23,218,101...23,224,667 		JBrowse link
G AGA aspartylglucosaminidase increases expression EXP masitinib results in increased expression of AGA mRNA CTD PMID:22747577 NCBI chr16:52,314,860...52,324,879
Ensembl chr16:52,314,535...52,324,894 		JBrowse link
G AGO2 argonaute RISC catalytic component 2 decreases expression EXP masitinib results in decreased expression of AGO2 mRNA CTD PMID:22747577 NCBI chr13:35,169,243...35,230,252
Ensembl chr13:35,180,912...35,268,577 		JBrowse link
G AGRN agrin increases expression EXP masitinib results in increased expression of AGRN mRNA CTD PMID:22747577 NCBI chr 5:56,239,621...56,273,679
Ensembl chr 5:56,239,701...56,272,745 		JBrowse link
G AIG1 androgen induced 1 increases expression EXP masitinib results in increased expression of AIG1 mRNA CTD PMID:22747577 NCBI chr 1:34,643,994...34,884,445
Ensembl chr 1:34,643,764...34,884,119 		JBrowse link
G ALAS2 5'-aminolevulinate synthase 2 increases expression EXP masitinib results in increased expression of ALAS2 mRNA CTD PMID:22747577 NCBI chr  X:46,703,477...46,731,767
Ensembl chr  X:46,703,477...46,723,529 		JBrowse link
G ALDH5A1 aldehyde dehydrogenase 5 family member A1 decreases expression EXP masitinib results in decreased expression of ALDH5A1 mRNA CTD PMID:22747577 NCBI chr35:22,560,005...22,590,996
Ensembl chr35:22,560,008...22,587,875 		JBrowse link
G AMN1 antagonist of mitotic exit network 1 homolog increases expression EXP masitinib results in increased expression of AMN1 mRNA CTD PMID:22747577 NCBI chr27:17,044,301...17,100,444
Ensembl chr27:17,044,309...17,361,570 		JBrowse link
G ANKRD26 ankyrin repeat domain containing 26 increases expression EXP masitinib results in increased expression of ANKRD26 mRNA CTD PMID:22747577 NCBI chr 2:6,230,466...6,402,360 JBrowse link
G ANP32E acidic nuclear phosphoprotein 32 family member E decreases expression EXP masitinib results in decreased expression of ANP32E mRNA CTD PMID:22747577 NCBI chr17:59,460,864...59,482,467
Ensembl chr17:59,462,766...59,477,936 		JBrowse link
G ANXA1 annexin A1 increases expression EXP masitinib results in increased expression of ANXA1 protein CTD PMID:22747577 NCBI chr 1:84,744,159...84,763,011
Ensembl chr 1:84,744,163...84,763,011 		JBrowse link
G ANXA6 annexin A6 increases expression EXP masitinib results in increased expression of ANXA6 protein CTD PMID:22747577 NCBI chr 4:58,091,186...58,140,102
Ensembl chr 4:58,091,251...58,139,372 		JBrowse link
G ARMC12 armadillo repeat containing 12 increases expression EXP masitinib results in increased expression of ARMC12 mRNA CTD PMID:22747577 NCBI chr12:4,868,831...4,879,801
Ensembl chr12:4,869,774...4,879,793 		JBrowse link
G ASCC1 activating signal cointegrator 1 complex subunit 1 decreases expression EXP masitinib results in decreased expression of ASCC1 mRNA CTD PMID:22747577 NCBI chr 4:22,779,644...22,876,434
Ensembl chr 4:22,779,781...22,874,215 		JBrowse link
G B4GALT7 beta-1,4-galactosyltransferase 7 increases expression EXP masitinib results in increased expression of B4GALT7 mRNA CTD PMID:22747577 NCBI chr11:3,497,860...3,507,513
Ensembl chr11:3,498,153...3,505,034 		JBrowse link
G BIRC5 baculoviral IAP repeat containing 5 decreases expression EXP masitinib results in decreased expression of BIRC5 mRNA CTD PMID:22747577 NCBI chr 9:2,930,308...2,959,307 JBrowse link
G BTBD3 BTB domain containing 3 decreases expression EXP masitinib results in decreased expression of BTBD3 mRNA CTD PMID:22747577 NCBI chr24:10,478,635...10,512,773
Ensembl chr24:10,479,900...10,512,185 		JBrowse link
G CA2 carbonic anhydrase 2 decreases expression EXP masitinib results in decreased expression of CA2 mRNA CTD PMID:22747577 NCBI chr29:31,959,225...31,975,309
Ensembl chr29:31,935,172...31,980,579 		JBrowse link
G CAMK2G calcium/calmodulin dependent protein kinase II gamma increases expression EXP masitinib results in increased expression of CAMK2G mRNA CTD PMID:22747577 NCBI chr 4:24,244,063...24,299,362
Ensembl chr 4:24,245,960...24,299,357 		JBrowse link
G CAPG capping actin protein, gelsolin like increases expression EXP masitinib results in increased expression of CAPG protein CTD PMID:22747577 NCBI chr17:39,619,429...39,640,944
Ensembl chr17:39,619,248...39,640,942 		JBrowse link
G CCT2 chaperonin containing TCP1 subunit 2 decreases expression EXP masitinib results in decreased expression of CCT2 protein CTD PMID:22747577 NCBI chr10:11,560,287...11,586,559
Ensembl chr10:11,560,396...11,578,433 		JBrowse link
G CD5L CD5 molecule like increases expression EXP masitinib results in increased expression of CD5L mRNA CTD PMID:22747577 NCBI chr 7:40,516,190...40,526,528
Ensembl chr 7:40,516,190...40,526,528 		JBrowse link
G CDADC1 cytidine and dCMP deaminase domain containing 1 increases expression EXP masitinib results in increased expression of CDADC1 mRNA CTD PMID:22747577 NCBI chr22:2,443,459...2,489,147
Ensembl chr22:2,436,206...2,489,016 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP masitinib results in increased expression of CDKN1A mRNA CTD PMID:22747577 NCBI chr12:5,746,898...5,755,103
Ensembl chr12:5,745,852...5,892,281 		JBrowse link
G CIAPIN1 cytokine induced apoptosis inhibitor 1 decreases expression EXP masitinib results in decreased expression of CIAPIN1 mRNA CTD PMID:22747577 NCBI chr 2:58,977,592...58,992,785
Ensembl chr 2:58,977,676...58,992,581 		JBrowse link
G CIRBP cold inducible RNA binding protein increases expression EXP masitinib results in increased expression of CIRBP mRNA CTD PMID:22747577 NCBI chr20:57,521,609...57,526,526
Ensembl chr20:57,519,119...57,526,435 		JBrowse link
G CLEC2B C-type lectin domain family 2 member B decreases expression EXP masitinib results in decreased expression of CLEC2B mRNA CTD PMID:22747577 NCBI chr27:36,088,754...36,143,581
Ensembl chr27:36,120,134...36,143,040 		JBrowse link
G CMTM7 CKLF like MARVEL transmembrane domain containing 7 increases expression EXP masitinib results in increased expression of CMTM7 mRNA CTD PMID:22747577 NCBI chr23:12,317,636...12,382,836
Ensembl chr23:12,328,303...12,382,837 		JBrowse link
G CORO1A coronin 1A increases expression EXP masitinib results in increased expression of CORO1A protein CTD PMID:22747577 NCBI chr 6:18,161,850...18,167,915
Ensembl chr 6:18,160,601...18,167,818 		JBrowse link
G CPNE1 copine 1 increases expression EXP masitinib results in increased expression of CPNE1 mRNA CTD PMID:22747577 NCBI chr24:24,554,636...24,589,748
Ensembl chr24:24,554,636...24,589,731 		JBrowse link
G CTSK cathepsin K increases expression EXP masitinib results in increased expression of CTSK mRNA CTD PMID:22747577 NCBI chr17:59,928,725...59,938,293
Ensembl chr17:59,929,287...59,938,507 		JBrowse link
G DHRS4 hydrogenase/reductase 4 increases expression EXP masitinib results in increased expression of DHRS4 mRNA CTD PMID:22747577 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744 		JBrowse link
G DLA-12 MHC class I DLA-12 increases expression EXP masitinib results in increased expression of DLA-12 mRNA CTD PMID:22747577 NCBI chr12:933,321...936,671
Ensembl chr12:932,613...987,561 		JBrowse link
G DLA-64 MHC class I DLA-64 increases expression EXP masitinib results in increased expression of DLA-64 mRNA CTD PMID:22747577 NCBI chr12:983,573...986,969 JBrowse link
G DLGAP1 DLG associated protein 1 decreases expression EXP masitinib results in decreased expression of DLGAP1 mRNA CTD PMID:22747577 NCBI chr 7:70,082,563...70,949,116
Ensembl chr 7:70,081,885...70,406,213 		JBrowse link
G DLGAP5 DLG associated protein 5 decreases expression EXP masitinib results in decreased expression of DLGAP5 mRNA CTD PMID:22747577 NCBI chr 8:30,998,806...31,038,614
Ensembl chr 8:30,994,402...31,036,540 		JBrowse link
G DPCD deleted in primary ciliary dyskinesia homolog decreases expression EXP masitinib results in decreased expression of DPCD mRNA CTD PMID:22747577 NCBI chr28:14,201,302...14,219,121
Ensembl chr28:14,201,351...14,219,121 		JBrowse link
G DPYSL3 dihydropyrimidinase like 3 decreases expression EXP masitinib results in decreased expression of DPYSL3 mRNA CTD PMID:22747577 NCBI chr 2:41,687,725...41,809,402
Ensembl chr 2:41,690,845...41,802,376 		JBrowse link
G EBPL EBP like increases expression EXP masitinib results in increased expression of EBPL mRNA CTD PMID:22747577 NCBI chr22:2,116,588...2,137,935
Ensembl chr22:2,116,131...2,182,633 		JBrowse link
G EDEM2 ER degradation enhancing alpha-mannosidase like protein 2 increases expression EXP masitinib results in increased expression of EDEM2 mRNA CTD PMID:22747577 NCBI chr24:24,137,228...24,165,995
Ensembl chr24:24,137,228...24,165,968 		JBrowse link
G EIF3A eukaryotic translation initiation factor 3 subunit A decreases expression EXP masitinib results in decreased expression of EIF3A protein CTD PMID:22747577 NCBI chr28:29,290,668...29,326,851
Ensembl chr28:29,291,422...29,326,701 		JBrowse link
G EIF4A1 eukaryotic translation initiation factor 4A1 decreases expression EXP masitinib results in decreased expression of EIF4A1 protein CTD PMID:22747577 NCBI chr 5:32,495,606...32,500,805
Ensembl chr 5:32,484,572...32,500,805 		JBrowse link
G EIF5A2 eukaryotic translation initiation factor 5A2 decreases expression EXP masitinib results in decreased expression of EIF5A2 mRNA CTD PMID:22747577 NCBI chr34:35,309,812...35,322,382
Ensembl chr34:35,314,172...35,322,392 		JBrowse link
G ELSPBP1 epididymal sperm binding protein 1 increases expression EXP masitinib results in increased expression of ELSPBP1 mRNA CTD PMID:22747577 NCBI chr 1:108,159,609...108,187,224
Ensembl chr 1:108,159,611...108,188,076 		JBrowse link
G ETFDH electron transfer flavoprotein dehydrogenase decreases expression EXP masitinib results in decreased expression of ETFDH mRNA CTD PMID:22747577 NCBI chr15:55,752,170...55,781,118
Ensembl chr15:55,752,200...55,792,105 		JBrowse link
G GGT1 gamma-glutamyltransferase 1 increases expression EXP masitinib results in increased expression of GGT1 mRNA CTD PMID:22747577 NCBI chr26:28,301,455...28,315,029 JBrowse link
G GKN1 gastrokine 1 increases expression EXP masitinib results in increased expression of GKN1 mRNA CTD PMID:22747577 NCBI chr10:67,788,329...67,793,445
Ensembl chr10:67,788,110...67,793,589 		JBrowse link
G GMFB glia maturation factor beta decreases expression EXP masitinib results in decreased expression of GMFB mRNA CTD PMID:22747577 NCBI chr 8:30,394,020...30,408,408
Ensembl chr 8:30,359,499...30,408,357 		JBrowse link
G GSTA4 glutathione S-transferase alpha 4 increases expression EXP masitinib results in increased expression of GSTA4 mRNA CTD PMID:22747577 NCBI chr12:20,426,724...20,443,200
Ensembl chr12:20,426,726...20,443,200 		JBrowse link
G GXYLT1 glucoside xylosyltransferase 1 decreases expression EXP masitinib results in decreased expression of GXYLT1 mRNA CTD PMID:22747577 NCBI chr27:11,754,609...11,810,245
Ensembl chr27:11,765,072...11,807,787 		JBrowse link
G HEBP2 heme binding protein 2 decreases expression EXP masitinib results in decreased expression of HEBP2 mRNA CTD PMID:22747577 NCBI chr 1:30,716,395...30,724,814
Ensembl chr 1:30,716,606...30,724,613 		JBrowse link
G HERPUD1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression EXP masitinib results in increased expression of HERPUD1 mRNA CTD PMID:22747577 NCBI chr 2:59,388,492...59,400,028
Ensembl chr 2:59,388,494...59,400,003 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP masitinib results in increased expression of HSP90B1 protein CTD PMID:22747577 NCBI chr15:42,456,793...42,474,122
Ensembl chr15:42,456,764...42,579,311 		JBrowse link
G HTR2B 5-hydroxytryptamine receptor 2B increases expression EXP masitinib results in increased expression of HTR2B mRNA CTD PMID:22747577 NCBI chr25:43,042,306...43,056,361
Ensembl chr25:43,042,173...43,056,612 		JBrowse link
G HYAL3 hyaluronidase 3 increases expression EXP masitinib results in increased expression of HYAL3 mRNA CTD PMID:22747577 NCBI chr20:39,041,940...39,047,388
Ensembl chr20:39,042,070...39,047,365 		JBrowse link
G IGFBP7 insulin like growth factor binding protein 7 increases expression EXP masitinib results in increased expression of IGFBP7 mRNA CTD PMID:22747577 NCBI chr13:49,138,406...49,207,235
Ensembl chr13:49,138,402...49,207,394 		JBrowse link
G IL13 interleukin 13 increases expression EXP masitinib results in increased expression of IL13 mRNA CTD PMID:22747577 NCBI chr11:20,957,870...20,961,391
Ensembl chr11:20,958,464...20,961,388 		JBrowse link
G IMMP2L inner mitochondrial membrane peptidase subunit 2 increases expression EXP masitinib results in increased expression of IMMP2L mRNA CTD PMID:22747577 NCBI chr14:50,487,679...51,336,906 JBrowse link
G IRX6 iroquois homeobox 6 increases expression EXP masitinib results in increased expression of IRX6 protein CTD PMID:22747577 NCBI chr 2:60,630,688...60,636,285
Ensembl chr 2:60,630,447...60,636,416 		JBrowse link
G ITGA6 integrin subunit alpha 6 decreases expression EXP masitinib results in decreased expression of ITGA6 mRNA CTD PMID:22747577 NCBI chr36:16,777,363...16,858,725
Ensembl chr36:16,776,863...16,855,449 		JBrowse link
G JAML junction adhesion molecule like decreases expression EXP masitinib results in decreased expression of JAML mRNA CTD PMID:22747577 NCBI chr 5:15,485,378...15,513,457
Ensembl chr 5:15,476,582...15,513,075 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit increases expression EXP masitinib results in increased expression of JUN mRNA CTD PMID:22747577 NCBI chr 5:50,966,698...50,968,939 JBrowse link
G KCTD19 potassium channel tetramerization domain containing 19 increases expression EXP masitinib results in increased expression of KCTD19 mRNA CTD PMID:22747577 NCBI chr 5:82,060,946...82,093,248
Ensembl chr 5:82,061,449...82,093,246 		JBrowse link
G KLHL5 kelch like family member 5 increases expression EXP masitinib results in increased expression of KLHL5 mRNA CTD PMID:22747577 NCBI chr 3:73,258,925...73,347,262
Ensembl chr 3:73,262,895...73,344,879 		JBrowse link
G LBX2 ladybird homeobox 2 increases expression EXP masitinib results in increased expression of LBX2 mRNA CTD PMID:22747577 NCBI chr17:48,641,630...48,643,411
Ensembl chr17:48,641,674...48,643,239 		JBrowse link
G LIN7C lin-7 homolog C, crumbs cell polarity complex component decreases expression EXP masitinib results in decreased expression of LIN7C mRNA CTD PMID:22747577 NCBI chr21:48,061,446...48,071,458
Ensembl chr21:48,064,929...48,071,429 		JBrowse link
G LOC474850 heat shock 70 kDa protein 1-like increases expression EXP masitinib results in increased expression of HSPA1L mRNA CTD PMID:22747577 NCBI chr12:1,281,164...1,285,010
Ensembl chr12:1,281,472...1,285,440 		JBrowse link
G LOC475707 GPN-loop GTPase 1 decreases expression EXP masitinib results in decreased expression of GPN1 mRNA CTD PMID:22747577 NCBI chr17:21,654,516...21,678,435
Ensembl chr17:21,545,673...21,673,157 		JBrowse link
G LOC478000 phytanoyl-CoA hydroxylase-like increases expression EXP masitinib results in increased expression of PHYH mRNA CTD PMID:22747577 NCBI chr 2:23,185,901...23,206,719
Ensembl chr 2:23,185,782...23,253,497 		JBrowse link
G LOC609402 hemoglobin subunit beta-like increases expression EXP masitinib results in increased expression of HBG1 mRNA CTD PMID:22747577 NCBI chr21:28,187,535...28,188,991 JBrowse link
G LONRF1 LON peptidase N-terminal domain and ring finger 1 increases expression EXP masitinib results in increased expression of LONRF1 mRNA CTD PMID:22747577 NCBI chr16:36,220,324...36,256,896
Ensembl chr16:36,221,156...36,256,897 		JBrowse link
G LRP1 LDL receptor related protein 1 increases expression EXP masitinib results in increased expression of LRP1 mRNA CTD PMID:22747577 NCBI chr10:1,260,256...1,341,705
Ensembl chr10:1,260,719...1,352,271 		JBrowse link
G LRP8 LDL receptor related protein 8 decreases expression EXP masitinib results in decreased expression of LRP8 mRNA CTD PMID:22747577 NCBI chr 5:55,604,878...55,684,666
Ensembl chr 5:55,604,878...55,699,736 		JBrowse link
G LYRM1 LYR motif containing 1 increases expression EXP masitinib results in increased expression of LYRM1 mRNA CTD PMID:22747577 NCBI chr 6:24,428,461...24,460,291
Ensembl chr 6:24,441,307...24,460,331 		JBrowse link
G MAGEF1 MAGE family member F1 decreases expression EXP masitinib results in decreased expression of MAGEF1 mRNA CTD PMID:22747577 NCBI chr34:17,543,381...17,545,089
Ensembl chr34:17,543,906...17,544,868 		JBrowse link
G MOB1B MOB kinase activator 1B decreases expression EXP masitinib results in decreased expression of MOB1B mRNA CTD PMID:22747577 NCBI chr13:60,145,168...60,197,916
Ensembl chr13:60,145,366...60,195,463 		JBrowse link
G MPDZ multiple PDZ domain crumbs cell polarity complex component increases expression EXP masitinib results in increased expression of MPDZ mRNA CTD PMID:22747577 NCBI chr11:33,691,434...33,826,500
Ensembl chr11:33,692,296...33,826,437 		JBrowse link
G MYOZ1 myozenin 1 increases expression EXP masitinib results in increased expression of MYOZ1 mRNA CTD PMID:22747577 NCBI chr 4:24,158,532...24,165,416
Ensembl chr 4:24,158,720...24,165,392 		JBrowse link
G NAPG NSF attachment protein gamma decreases expression EXP masitinib results in decreased expression of NAPG mRNA CTD PMID:22747577 NCBI chr 7:76,403,561...76,424,994
Ensembl chr 7:76,403,595...76,423,170 		JBrowse link
G NDUFS1 NADH:ubiquinone oxidoreductase core subunit S1 decreases expression EXP masitinib results in decreased expression of NDUFS1 mRNA CTD PMID:22747577 NCBI chr37:14,680,908...14,713,838
Ensembl chr37:14,683,083...14,713,754 		JBrowse link
G NFKBIA NFKB inhibitor alpha increases expression EXP masitinib results in increased expression of NFKBIA mRNA CTD PMID:22747577 NCBI chr 8:14,100,203...14,103,453
Ensembl chr 8:14,100,671...14,103,433 		JBrowse link
G NRAS NRAS proto-oncogene, GTPase decreases expression EXP masitinib results in decreased expression of NRAS mRNA CTD PMID:22747577 NCBI chr17:52,411,733...52,418,788
Ensembl chr17:52,411,733...52,418,788 		JBrowse link
G NSG1 neuronal vesicle trafficking associated 1 decreases expression EXP masitinib results in decreased expression of NSG1 mRNA CTD PMID:22747577 NCBI chr 3:69,805,646...69,831,200
Ensembl chr 3:69,805,592...69,831,194 		JBrowse link
G NTRK1 neurotrophic receptor tyrosine kinase 1 increases expression EXP masitinib results in increased expression of NTRK1 mRNA CTD PMID:22747577 NCBI chr 7:41,140,931...41,159,326
Ensembl chr 7:41,140,879...41,159,288 		JBrowse link
G OCA2 OCA2 melanosomal transmembrane protein decreases expression EXP masitinib results in decreased expression of OCA2 mRNA CTD PMID:22747577 NCBI chr 3:32,361,825...32,713,631
Ensembl chr 3:32,361,517...32,713,572 		JBrowse link
G OGT O-linked N-acetylglucosamine (GlcNAc) transferase increases expression EXP masitinib results in increased expression of OGT mRNA CTD PMID:22747577 NCBI chr  X:55,821,227...55,857,597
Ensembl chr  X:55,821,234...55,855,502 		JBrowse link
G OXCT1 3-oxoacid CoA-transferase 1 increases expression EXP masitinib results in increased expression of OXCT1 protein CTD PMID:22747577 NCBI chr 4:67,709,846...67,841,737
Ensembl chr 4:67,527,531...67,841,518 		JBrowse link
G PARP14 poly(ADP-ribose) polymerase family member 14 increases expression EXP masitinib results in increased expression of PARP14 mRNA CTD PMID:22747577 NCBI chr33:25,763,282...25,798,284
Ensembl chr33:25,763,255...25,798,198 		JBrowse link
G PCM1 pericentriolar material 1 increases expression EXP masitinib results in increased expression of PCM1 mRNA CTD PMID:22747577 NCBI chr16:41,212,733...41,291,654
Ensembl chr16:41,214,417...41,291,376 		JBrowse link
G PCOLCE2 procollagen C-endopeptidase enhancer 2 decreases expression EXP masitinib results in decreased expression of PCOLCE2 mRNA CTD PMID:22747577 NCBI chr23:38,424,408...38,486,800
Ensembl chr23:38,426,216...38,487,252 		JBrowse link
G PDE6H phosphodiesterase 6H increases expression EXP masitinib results in increased expression of PDE6H mRNA CTD PMID:22747577 NCBI chr27:31,640,731...31,664,494
Ensembl chr27:31,640,737...31,664,401 		JBrowse link
G PDHA1 pyruvate dehydrogenase E1 subunit alpha 1 decreases expression EXP masitinib results in decreased expression of PDHA1 mRNA CTD PMID:22747577 NCBI chr  X:15,338,364...15,354,011
Ensembl chr  X:15,338,202...15,387,458 		JBrowse link
G PDIA3 protein disulfide isomerase family A member 3 increases expression EXP masitinib results in increased expression of PDIA3 protein CTD PMID:22747577 NCBI chr30:10,487,926...10,513,437
Ensembl chr30:10,487,921...10,513,397 		JBrowse link
G PEBP4 phosphatidylethanolamine binding protein 4 increases expression EXP masitinib results in increased expression of PEBP4 mRNA CTD PMID:22747577 NCBI chr25:34,329,160...34,574,086
Ensembl chr25:34,317,421...34,574,066 		JBrowse link
G PECAM1 platelet and endothelial cell adhesion molecule 1 increases expression EXP masitinib results in increased expression of PECAM1 mRNA CTD PMID:22747577 NCBI chr 9:12,166,124...12,219,553
Ensembl chr 9:12,166,775...12,219,778 		JBrowse link
G PHF10 PHD finger protein 10 increases expression EXP masitinib results in increased expression of PHF10 mRNA CTD PMID:22747577 NCBI chr12:71,955,354...71,998,283
Ensembl chr12:71,787,082...71,998,243 		JBrowse link
G POMT1 protein O-mannosyltransferase 1 decreases expression EXP masitinib results in decreased expression of POMT1 mRNA CTD PMID:22747577 NCBI chr 9:52,615,349...52,631,538
Ensembl chr 9:52,615,655...52,630,836 		JBrowse link
G POR cytochrome p450 oxidoreductase increases expression EXP masitinib results in increased expression of POR mRNA CTD PMID:22747577 NCBI chr 6:7,247,780...7,316,282
Ensembl chr 6:7,263,574...7,316,297 		JBrowse link
G PPA1 inorganic pyrophosphatase 1 decreases expression EXP masitinib results in decreased expression of PPA1 protein CTD PMID:22747577 NCBI chr 4:21,145,547...21,189,985
Ensembl chr 4:21,145,547...21,182,748 		JBrowse link
G PRPS2 phosphoribosyl pyrophosphate synthetase 2 decreases expression EXP masitinib results in decreased expression of PRPS2 mRNA CTD PMID:22747577 NCBI chr  X:9,281,686...9,326,551
Ensembl chr  X:9,281,730...9,418,289 		JBrowse link
G PSMB9 proteasome 20S subunit beta 9 increases expression EXP masitinib results in increased expression of PSMB9 mRNA CTD PMID:22747577 NCBI chr12:2,432,287...2,438,920
Ensembl chr12:2,432,505...2,438,069 		JBrowse link
G PSMD6 proteasome 26S subunit, non-ATPase 6 decreases expression EXP masitinib results in decreased expression of PSMD6 protein CTD PMID:22747577 NCBI chr20:27,206,801...27,220,059 JBrowse link
G PSMD9 proteasome 26S subunit, non-ATPase 9 decreases expression EXP masitinib results in decreased expression of PSMD9 mRNA CTD PMID:22747577 NCBI chr26:7,376,154...7,400,655
Ensembl chr26:7,377,413...7,400,573 		JBrowse link
G PTH parathyroid hormone increases expression EXP masitinib results in increased expression of PTH mRNA CTD PMID:22747577 NCBI chr21:36,417,062...36,419,967
Ensembl chr21:36,417,058...36,419,967 		JBrowse link
G PXYLP1 2-phosphoxylose phosphatase 1 decreases expression EXP masitinib results in decreased expression of ACPL2 mRNA CTD PMID:22747577 NCBI chr23:37,145,065...37,197,808
Ensembl chr23:37,145,086...37,196,427 		JBrowse link
G R3HDM2 R3H domain containing 2 increases expression EXP masitinib results in increased expression of R3HDM2 mRNA CTD PMID:22747577 NCBI chr10:1,377,664...1,504,008
Ensembl chr10:1,370,350...1,504,017 		JBrowse link
G RAB44 RAB44, member RAS oncogene family increases expression EXP masitinib results in increased expression of RAB44 mRNA CTD PMID:22747577 NCBI chr12:5,769,056...5,804,963
Ensembl chr12:5,770,882...5,804,949 		JBrowse link
G RASGRP2 RAS guanyl releasing protein 2 increases expression EXP masitinib results in increased expression of RASGRP2 mRNA CTD PMID:22747577 NCBI chr18:52,412,331...52,426,910
Ensembl chr18:52,412,367...52,426,916 		JBrowse link
G RCAN1 regulator of calcineurin 1 increases expression EXP masitinib results in increased expression of RCAN1 mRNA CTD PMID:22747577 NCBI chr31:29,908,046...30,002,412
Ensembl chr31:29,909,388...30,002,418 		JBrowse link
G RGS13 regulator of G protein signaling 13 decreases expression EXP masitinib results in decreased expression of RGS13 mRNA CTD PMID:22747577 NCBI chr38:6,291,146...6,316,662
Ensembl chr38:6,291,182...6,315,198 		JBrowse link
G SAR1A secretion associated Ras related GTPase 1A decreases expression EXP masitinib results in decreased expression of SAR1A mRNA CTD PMID:22747577 NCBI chr 4:21,120,788...21,136,409
Ensembl chr 4:21,123,028...21,136,973 		JBrowse link
G SCD stearoyl-CoA desaturase decreases expression EXP masitinib results in decreased expression of SCD mRNA CTD PMID:22747577 NCBI chr28:13,112,741...13,129,129
Ensembl chr28:13,113,006...13,125,801 		JBrowse link
G SELENBP1 selenium binding protein 1 increases expression EXP masitinib results in increased expression of SELENBP1 protein CTD PMID:22747577 NCBI chr17:60,410,727...60,418,770
Ensembl chr17:60,410,734...60,418,704 		JBrowse link
G SERPINE2 serpin family E member 2 increases expression EXP masitinib results in increased expression of SERPINE2 mRNA CTD PMID:22747577 NCBI chr37:29,699,551...29,750,151
Ensembl chr37:29,700,024...29,724,228 		JBrowse link
G SFT2D2 SFT2 domain containing 2 decreases expression EXP masitinib results in decreased expression of SFT2D2 mRNA CTD PMID:22747577 NCBI chr 7:30,258,748...30,281,371 JBrowse link
G SLA Src like adaptor increases expression EXP masitinib results in increased expression of SLA mRNA CTD PMID:22747577 NCBI chr13:29,503,304...29,590,679
Ensembl chr13:29,504,867...29,569,773 		JBrowse link
G SLC25A12 solute carrier family 25 member 12 decreases expression EXP masitinib results in decreased expression of SLC25A12 mRNA CTD PMID:22747577 NCBI chr36:16,185,011...16,391,080
Ensembl chr36:16,185,649...16,483,016 		JBrowse link
G SMC5 structural maintenance of chromosomes 5 decreases expression EXP masitinib results in decreased expression of SMC5 mRNA CTD PMID:22747577 NCBI chr 1:87,192,988...87,285,678
Ensembl chr 1:87,194,867...87,285,606 		JBrowse link
G SRR serine racemase increases expression EXP masitinib results in increased expression of SRR mRNA CTD PMID:22747577
G STING1 stimulator of interferon response cGAMP interactor 1 increases expression EXP masitinib results in increased expression of TMEM173 mRNA CTD PMID:22747577 NCBI chr 2:34,783,947...34,792,204
Ensembl chr 2:34,784,232...34,789,072 		JBrowse link
G STOX1 storkhead box 1 increases expression EXP masitinib results in increased expression of STOX1 mRNA CTD PMID:22747577 NCBI chr 4:20,013,893...20,065,480
Ensembl chr 4:20,014,007...20,060,394 		JBrowse link
G STX16 syntaxin 16 increases expression EXP masitinib results in increased expression of STX16 mRNA CTD PMID:22747577 NCBI chr24:43,425,719...43,451,828
Ensembl chr24:43,426,470...43,449,077 		JBrowse link
G STYXL1 serine/threonine/tyrosine interacting like 1 increases expression EXP masitinib results in increased expression of STYXL1 mRNA CTD PMID:22747577 NCBI chr 6:7,323,911...7,389,878
Ensembl chr 6:7,316,477...7,389,842 		JBrowse link
G TARDBP TAR DNA binding protein decreases expression EXP masitinib results in decreased expression of TARDBP protein CTD PMID:22747577 NCBI chr 2:84,987,752...84,998,136
Ensembl chr 2:84,989,952...84,998,593 		JBrowse link
G TBC1D14 TBC1 domain family member 14 decreases expression EXP masitinib results in decreased expression of TBC1D14 mRNA CTD PMID:22747577 NCBI chr 3:58,992,743...59,097,581
Ensembl chr 3:58,926,237...59,097,621 		JBrowse link
G TCN2 transcobalamin 2 increases expression EXP masitinib results in increased expression of TCN2 mRNA CTD PMID:22747577 NCBI chr26:23,693,664...23,710,342
Ensembl chr26:23,693,773...23,709,832 		JBrowse link
G TCP1 t-complex 1 decreases expression EXP masitinib results in decreased expression of TCP1 protein CTD PMID:22747577 NCBI chr 1:49,029,260...49,038,023
Ensembl chr 1:49,029,282...49,038,020 		JBrowse link
G TEAD4 TEA domain transcription factor 4 increases expression EXP masitinib results in increased expression of TEAD4 mRNA CTD PMID:22747577 NCBI chr27:41,744,100...41,783,223
Ensembl chr27:41,748,871...41,803,556 		JBrowse link
G THEMIS2 thymocyte selection associated family member 2 decreases expression EXP masitinib results in decreased expression of THEMIS2 mRNA CTD PMID:22747577 NCBI chr 2:72,465,719...72,501,962
Ensembl chr 2:72,464,026...72,502,928 		JBrowse link
G TM2D2 TM2 domain containing 2 increases expression EXP masitinib results in increased expression of TM2D2 mRNA CTD PMID:22747577 NCBI chr16:26,551,563...26,557,554
Ensembl chr16:26,551,628...26,556,285 		JBrowse link
G TMEM108 transmembrane protein 108 increases expression EXP masitinib results in increased expression of TMEM108 mRNA CTD PMID:22747577 NCBI chr23:29,992,038...30,331,791
Ensembl chr23:29,992,021...30,396,840 		JBrowse link
G TMEM260 transmembrane protein 260 increases expression EXP masitinib results in increased expression of TMEM260 mRNA CTD PMID:22747577 NCBI chr 8:32,238,992...32,309,320
Ensembl chr 8:32,238,988...32,306,317 		JBrowse link
G TNFSF10 TNF superfamily member 10 increases expression EXP masitinib results in increased expression of TNFSF10 mRNA CTD PMID:22747577 NCBI chr34:36,719,249...36,734,989
Ensembl chr34:36,670,849...36,735,060 		JBrowse link
G TNPO1 transportin 1 decreases expression EXP masitinib results in decreased expression of TNPO1 mRNA CTD PMID:22747577 NCBI chr 2:55,795,737...55,859,366
Ensembl chr 2:55,799,907...55,851,213 		JBrowse link
G TNS1 tensin 1 decreases expression EXP masitinib results in decreased expression of TNS1 mRNA CTD PMID:22747577 NCBI chr37:24,578,855...24,776,153
Ensembl chr37:24,581,806...24,808,049 		JBrowse link
G TOX thymocyte selection associated high mobility group box increases expression EXP masitinib results in increased expression of TOX mRNA CTD PMID:22747577 NCBI chr29:9,542,471...9,841,759
Ensembl chr29:9,544,561...9,842,034 		JBrowse link
G TSHB thyroid stimulating hormone subunit beta increases expression EXP masitinib results in increased expression of TSHB mRNA CTD PMID:22747577 NCBI chr17:52,659,137...52,685,388
Ensembl chr17:52,681,357...52,685,390 		JBrowse link
G TSPAN2 tetraspanin 2 increases expression EXP masitinib results in increased expression of TSPAN2 mRNA CTD PMID:22747577 NCBI chr17:52,692,744...52,749,048
Ensembl chr17:52,694,603...52,744,276 		JBrowse link
G TTC38 tetratricopeptide repeat domain 38 increases expression EXP masitinib results in increased expression of TTC38 protein CTD PMID:22747577 NCBI chr10:19,887,285...19,910,347
Ensembl chr10:19,773,373...19,910,683 		JBrowse link
G TTLL1 TTL family tubulin polyglutamylase complex subunit L1 decreases expression EXP masitinib results in decreased expression of TTLL1 mRNA CTD PMID:22747577 NCBI chr10:22,456,150...22,492,375
Ensembl chr10:22,456,146...22,488,505 		JBrowse link
G UCHL3 ubiquitin C-terminal hydrolase L3 increases expression EXP masitinib results in increased expression of UCHL3 protein CTD PMID:22747577 NCBI chr22:29,348,962...29,397,944
Ensembl chr22:29,348,706...29,407,965 		JBrowse link
G UQCC1 ubiquinol-cytochrome c reductase complex assembly factor 1 decreases expression EXP masitinib results in decreased expression of UQCC1 mRNA CTD PMID:22747577 NCBI chr24:24,285,147...24,381,819
Ensembl chr24:24,286,320...24,381,699 		JBrowse link
G UROD uroporphyrinogen decarboxylase increases expression EXP masitinib results in increased expression of UROD protein CTD PMID:22747577 NCBI chr15:15,313,808...15,317,130
Ensembl chr15:15,312,674...15,320,010 		JBrowse link
G UROS uroporphyrinogen III synthase increases expression EXP masitinib results in increased expression of UROS mRNA CTD PMID:22747577 NCBI chr28:34,952,074...34,983,532
Ensembl chr28:34,948,003...34,983,532 		JBrowse link
G VCPKMT valosin containing protein lysine methyltransferase decreases expression EXP masitinib results in decreased expression of VCPKMT mRNA CTD PMID:22747577 NCBI chr 8:26,611,333...26,636,700
Ensembl chr 8:26,625,677...26,636,316 		JBrowse link
G WAPL WAPL cohesin release factor decreases expression EXP masitinib results in decreased expression of WAPAL mRNA CTD PMID:22747577 NCBI chr 4:34,219,644...34,297,456
Ensembl chr 4:34,219,645...34,302,839 		JBrowse link
G YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta increases expression EXP masitinib results in increased expression of YWHAZ protein CTD PMID:22747577 NCBI chr13:2,729,404...2,764,422 JBrowse link
G ZNF23 zinc finger protein 23 increases expression EXP masitinib results in increased expression of ZNF23 mRNA CTD PMID:22747577 NCBI chr 5:77,246,374...77,260,761
Ensembl chr 5:77,246,667...77,260,350 		JBrowse link
mastoparan term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GNAQ G protein subunit alpha q multiple interactions EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]; ganglioside, GD1a inhibits the reaction [mastoparan results in increased activity of and affects the localization of GNAQ protein]; mastoparan results in increased activity of and affects the localization of GNAQ protein CTD PMID:21671308 NCBI chr 1:80,733,530...80,928,065
Ensembl chr 1:80,715,366...80,928,065 		JBrowse link
G HEXB hexosaminidase subunit beta multiple interactions
increases secretion		 EXP G(M1) Ganglioside inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; ganglioside, GD1a inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; Indomethacin promotes the reaction [mastoparan results in increased secretion of HEXB protein]; methyl-beta-cyclodextrin promotes the reaction [mastoparan results in increased secretion of HEXB protein]; Pertussis Toxin inhibits the reaction [mastoparan results in increased secretion of HEXB protein]; Quinacrine promotes the reaction [mastoparan results in increased secretion of HEXB protein]; YM-254890 inhibits the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417 		JBrowse link
melittin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions
increases secretion		 EXP G(M1) Ganglioside inhibits the reaction [Melitten results in increased secretion of HEXB protein]; sialogangliosides inhibits the reaction [Melitten results in increased secretion of HEXB protein]; trisialoganglioside GT1 inhibits the reaction [Melitten results in increased secretion of HEXB protein] CTD PMID:21334356 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417 		JBrowse link
mephenytoin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2B6 cytochrome P450 2B11 increases hydroxylation EXP CYP2B6 protein results in increased hydroxylation of Mephenytoin CTD PMID:12637241 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293 		JBrowse link
metoprolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of ATP2A2 protein CTD PMID:18820026 NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388 		JBrowse link
G CYP2D15 cytochrome P450 family 2 subfamily D member 15 affects metabolic processing EXP CYP2D15 affects the metabolism of Metoprolol CTD PMID:7786018 NCBI chr10:23,255,259...23,259,380
Ensembl chr10:23,255,249...23,259,298 		JBrowse link
G EGR1 early growth response 1 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of EGR1 protein CTD PMID:18820026 NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575 		JBrowse link
G GATA4 GATA binding protein 4 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein CTD PMID:18820026 NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989 		JBrowse link
G NAB1 NGFI-A binding protein 1 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of NAB1 protein CTD PMID:18820026 NCBI chr37:1,207,619...1,243,546
Ensembl chr37:1,207,638...1,241,610 		JBrowse link
G SLC8A1 solute carrier family 8 member A1 multiple interactions EXP [Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein CTD PMID:18820026 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700 		JBrowse link
mexiletine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases response to substance EXP ABCB1 mutant form results in increased susceptibility to Mexiletine CTD PMID:16594604 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
midazolam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 affects metabolic processing EXP CYP3A4 protein affects the metabolism of Midazolam; CYP3A5 protein affects the metabolism of Midazolam CTD PMID:15801540 NCBI chr 6:9,836,685...9,869,520
Ensembl chr 6:9,777,659...9,869,352 		JBrowse link
ML-7 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin] CTD PMID:20510202 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G MYLK myosin light chain kinase multiple interactions EXP [ML 7 results in decreased activity of MYLK protein] affects the reaction [ABCB1 protein affects the transport of Digoxin] CTD PMID:20510202 NCBI chr33:26,663,991...26,867,370
Ensembl chr33:26,664,800...26,843,181 		JBrowse link
mocetinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKAP12 A-kinase anchoring protein 12 increases expression EXP mocetinostat results in increased expression of AKAP12 mRNA CTD PMID:27255383 NCBI chr 1:41,614,893...41,712,350
Ensembl chr 1:41,614,714...41,709,798 		JBrowse link
G ANK1 ankyrin 1 decreases expression EXP mocetinostat results in decreased expression of ANK1 mRNA CTD PMID:27255383 NCBI chr16:23,858,299...23,966,181
Ensembl chr16:23,766,193...23,964,226 		JBrowse link
G ANK3 ankyrin 3 increases expression EXP mocetinostat results in increased expression of ANK3 mRNA CTD PMID:27255383 NCBI chr 4:12,166,275...12,827,175
Ensembl chr 4:12,167,550...12,827,037 		JBrowse link
G AP2M1 adaptor related protein complex 2 subunit mu 1 decreases expression EXP mocetinostat results in decreased expression of AP2M1 mRNA CTD PMID:27255383 NCBI chr34:17,071,199...17,080,445
Ensembl chr34:17,071,235...17,080,445 		JBrowse link
G AP2S1 adaptor related protein complex 2 subunit sigma 1 decreases expression EXP mocetinostat results in decreased expression of AP2S1 mRNA CTD PMID:27255383 NCBI chr 1:109,094,098...109,105,233
Ensembl chr 1:109,082,221...109,105,230 		JBrowse link
G AP3S1 adaptor related protein complex 3 subunit sigma 1 increases expression EXP mocetinostat results in increased expression of AP3S1 mRNA CTD PMID:27255383 NCBI chr11:5,543,140...5,611,322
Ensembl chr11:5,543,222...5,610,930 		JBrowse link
G ARF4 ADP ribosylation factor 4 increases expression EXP mocetinostat results in increased expression of ARF4 mRNA CTD PMID:27255383 NCBI chr20:32,849,725...32,871,127
Ensembl chr20:32,849,757...32,870,721 		JBrowse link
G ATG4D autophagy related 4D cysteine peptidase decreases expression EXP mocetinostat results in decreased expression of ATG4D mRNA CTD PMID:27255383 NCBI chr20:50,618,458...50,623,703
Ensembl chr20:50,618,459...50,624,179 		JBrowse link
G ATG7 autophagy related 7 decreases expression EXP mocetinostat results in decreased expression of ATG7 mRNA CTD PMID:27255383 NCBI chr20:6,916,354...7,154,849
Ensembl chr20:6,916,515...7,154,800 		JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 increases expression EXP mocetinostat results in increased expression of ATP1A1 mRNA CTD PMID:27255383 NCBI chr17:53,828,482...53,847,043
Ensembl chr17:53,813,976...53,847,167 		JBrowse link
G BCAP29 B cell receptor associated protein 29 increases expression EXP mocetinostat results in increased expression of BCAP29 mRNA CTD PMID:27255383 NCBI chr18:12,969,594...13,021,948
Ensembl chr18:12,970,411...13,022,022 		JBrowse link
G BLOC1S1 biogenesis of lysosomal organelles complex 1 subunit 1 decreases expression EXP mocetinostat results in decreased expression of BLOC1S1 mRNA CTD PMID:27255383 NCBI chr10:116,993...120,244 JBrowse link
G BNIP1 BCL2 interacting protein 1 decreases expression EXP mocetinostat results in decreased expression of BNIP1 mRNA CTD PMID:27255383 NCBI chr 4:39,255,685...39,303,485
Ensembl chr 4:39,289,776...39,303,430 		JBrowse link
G CACNB3 calcium voltage-gated channel auxiliary subunit beta 3 increases expression EXP mocetinostat results in increased expression of CACNB3 mRNA CTD PMID:27255383 NCBI chr27:5,705,587...5,714,620
Ensembl chr27:5,706,064...5,717,647 		JBrowse link
G CAMK1D calcium/calmodulin dependent protein kinase ID increases expression EXP mocetinostat results in increased expression of CAMK1D mRNA CTD PMID:27255383 NCBI chr 2:23,680,395...24,113,922
Ensembl chr 2:23,685,672...24,114,084 		JBrowse link
G CASK calcium/calmodulin dependent serine protein kinase increases expression EXP mocetinostat results in increased expression of CASK mRNA CTD PMID:27255383 NCBI chr  X:35,939,117...36,296,438
Ensembl chr  X:35,940,647...36,297,014 		JBrowse link
G CAV1 caveolin 1 increases expression EXP mocetinostat results in increased expression of CAV1 mRNA CTD PMID:27255383 NCBI chr14:55,458,934...55,494,563
Ensembl chr14:55,461,048...55,492,935 		JBrowse link
G CBY1 chibby 1, beta catenin antagonist decreases expression EXP mocetinostat results in decreased expression of CBY1 mRNA CTD PMID:27255383 NCBI chr10:26,125,064...26,134,693
Ensembl chr10:26,125,189...26,128,285 		JBrowse link
G CHMP4B charged multivesicular body protein 4B decreases expression EXP mocetinostat results in decreased expression of CHMP4B mRNA CTD PMID:27255383 NCBI chr24:22,995,677...23,050,084
Ensembl chr24:22,995,672...23,049,287 		JBrowse link
G CHMP5 charged multivesicular body protein 5 decreases expression EXP mocetinostat results in decreased expression of CHMP5 mRNA CTD PMID:27255383 NCBI chr11:50,363,488...50,376,081 JBrowse link
G CHMP6 charged multivesicular body protein 6 decreases expression EXP mocetinostat results in decreased expression of CHMP6 mRNA CTD PMID:27255383 NCBI chr 9:997,951...1,001,659
Ensembl chr 9:998,653...1,002,538 		JBrowse link
G CLTCL1 clathrin heavy chain like 1 increases expression EXP mocetinostat results in increased expression of CLTCL1 mRNA CTD PMID:27255383 NCBI chr26:29,907,235...30,002,136
Ensembl chr26:29,906,278...30,002,128 		JBrowse link
G COPB1 COPI coat complex subunit beta 1 increases expression EXP mocetinostat results in increased expression of COPB1 mRNA CTD PMID:27255383 NCBI chr21:37,186,380...37,224,549
Ensembl chr21:37,186,424...37,224,519 		JBrowse link
G COPB2 COPI coat complex subunit beta 2 decreases expression EXP mocetinostat results in decreased expression of COPB2 mRNA CTD PMID:27255383 NCBI chr23:35,536,520...35,604,708
Ensembl chr23:35,536,615...35,566,569 		JBrowse link
G COPG1 COPI coat complex subunit gamma 1 decreases expression EXP mocetinostat results in decreased expression of COPG1 mRNA CTD PMID:27255383 NCBI chr20:2,832,150...2,860,356
Ensembl chr20:2,832,198...2,860,320 		JBrowse link
G DERL2 derlin 2 decreases expression EXP mocetinostat results in decreased expression of DERL2 mRNA CTD PMID:27255383 NCBI chr 5:31,319,660...31,330,846
Ensembl chr 5:31,319,717...31,330,841 		JBrowse link
G DNM1L dynamin 1 like decreases expression EXP mocetinostat results in decreased expression of DNM1L mRNA CTD PMID:27255383 NCBI chr27:16,161,855...16,211,983
Ensembl chr27:16,163,357...16,211,957 		JBrowse link
G GPAA1 glycosylphosphatidylinositol anchor attachment 1 decreases expression EXP mocetinostat results in decreased expression of GPAA1 mRNA CTD PMID:27255383 NCBI chr13:37,577,162...37,580,346
Ensembl chr13:37,576,354...37,580,345 		JBrowse link
G HPS4 HPS4 biogenesis of lysosomal organelles complex 3 subunit 2 decreases expression EXP mocetinostat results in decreased expression of HPS4 mRNA CTD PMID:27255383 NCBI chr26:20,131,658...20,157,532
Ensembl chr26:19,933,281...20,157,058 		JBrowse link
G HRC histidine rich calcium binding protein decreases expression EXP mocetinostat results in decreased expression of HRC mRNA CTD PMID:27255383 NCBI chr 1:107,304,718...107,308,741
Ensembl chr 1:107,304,924...107,308,740 		JBrowse link
G KCNK1 potassium two pore domain channel subfamily K member 1 increases expression EXP mocetinostat results in increased expression of KCNK1 mRNA CTD PMID:27255383 NCBI chr 4:6,117,406...6,139,390
Ensembl chr 4:6,118,373...6,122,093 		JBrowse link
G KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 increases expression EXP mocetinostat results in increased expression of KCNMB4 mRNA CTD PMID:27255383 NCBI chr10:12,211,372...12,251,739 JBrowse link
G KCNS3 potassium voltage-gated channel modifier subfamily S member 3 increases expression EXP mocetinostat results in increased expression of KCNS3 mRNA CTD PMID:27255383 NCBI chr17:13,297,242...13,338,319
Ensembl chr17:13,336,374...13,337,849 		JBrowse link
G KIF5A kinesin family member 5A increases expression EXP mocetinostat results in increased expression of KIF5A mRNA CTD PMID:27255383 NCBI chr10:1,637,007...1,666,790
Ensembl chr10:1,636,932...1,664,767 		JBrowse link
G KIF5B kinesin family member 5B decreases expression EXP mocetinostat results in decreased expression of KIF5B mRNA CTD PMID:27255383 NCBI chr 2:14,835,906...14,880,896
Ensembl chr 2:14,835,901...14,878,251 		JBrowse link
G KIF5C kinesin family member 5C increases expression EXP mocetinostat results in increased expression of KIF5C mRNA CTD PMID:27255383 NCBI chr19:50,535,622...50,684,485
Ensembl chr19:50,535,456...50,668,738 		JBrowse link
G LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 decreases expression EXP mocetinostat results in decreased expression of LAMTOR1 mRNA CTD PMID:27255383 NCBI chr21:25,981,170...25,986,942
Ensembl chr21:25,981,254...25,996,432 		JBrowse link
G LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 decreases expression EXP mocetinostat results in decreased expression of LAMTOR2 mRNA CTD PMID:27255383 NCBI chr 7:41,760,632...41,764,926
Ensembl chr 7:41,760,638...41,763,299 		JBrowse link
G LOC478702 tubulin beta-2B chain increases expression EXP mocetinostat results in increased expression of TUBB2B mRNA CTD PMID:27255383 NCBI chr35:3,494,982...3,498,274
Ensembl chr35:3,495,277...3,498,248 		JBrowse link
G MAL2 mal, T cell differentiation protein 2 increases expression EXP mocetinostat results in increased expression of MAL2 mRNA CTD PMID:27255383 NCBI chr13:18,404,979...18,422,076
Ensembl chr13:18,406,633...18,420,469 		JBrowse link
G MICAL1 microtubule associated monooxygenase, calponin and LIM domain containing 1 increases expression EXP mocetinostat results in increased expression of MICAL1 mRNA CTD PMID:27255383 NCBI chr12:66,350,459...66,358,391
Ensembl chr12:66,350,427...66,360,615 		JBrowse link
G MYPN myopalladin decreases expression EXP mocetinostat results in decreased expression of MYPN mRNA CTD PMID:27255383 NCBI chr 4:19,364,146...19,468,827
Ensembl chr 4:19,381,416...19,465,995 		JBrowse link
G PEX19 peroxisomal biogenesis factor 19 decreases expression EXP mocetinostat results in decreased expression of PEX19 mRNA CTD PMID:27255383 NCBI chr38:21,939,054...21,945,281
Ensembl chr38:21,939,018...21,944,602 		JBrowse link
G POLE2 DNA polymerase epsilon 2, accessory subunit increases expression EXP mocetinostat results in increased expression of DNAAF2 mRNA CTD PMID:27255383 NCBI chr 8:26,264,220...26,295,089
Ensembl chr 8:26,251,160...26,295,317 		JBrowse link
G PPP3CA protein phosphatase 3 catalytic subunit alpha increases expression EXP mocetinostat results in increased expression of PPP3CA mRNA CTD PMID:27255383 NCBI chr32:22,688,141...22,996,693
Ensembl chr32:22,688,143...22,996,688 		JBrowse link
G RAB27A RAB27A, member RAS oncogene family increases expression EXP mocetinostat results in increased expression of RAB27A mRNA CTD PMID:27255383 NCBI chr30:20,633,576...20,706,240
Ensembl chr30:20,635,400...20,690,521 		JBrowse link
G RAB31 RAB31, member RAS oncogene family increases expression EXP mocetinostat results in increased expression of RAB31 mRNA CTD PMID:27255383 NCBI chr 7:75,678,896...75,807,716
Ensembl chr 7:75,678,908...75,817,426 		JBrowse link
G RAB3IP RAB3A interacting protein increases expression EXP mocetinostat results in increased expression of RAB3IP mRNA CTD PMID:27255383 NCBI chr10:11,673,749...11,714,282
Ensembl chr10:11,673,777...11,714,281 		JBrowse link
G RABEPK Rab9 effector protein with kelch motifs increases expression EXP mocetinostat results in increased expression of RABEPK mRNA CTD PMID:27255383 NCBI chr 9:57,857,269...57,877,333
Ensembl chr 9:57,857,269...57,883,761 		JBrowse link
G SCAMP3 secretory carrier membrane protein 3 decreases expression EXP mocetinostat results in decreased expression of SCAMP3 mRNA CTD PMID:27255383 NCBI chr 7:42,294,764...42,299,097 JBrowse link
G SCN10A sodium voltage-gated channel alpha subunit 10 increases expression EXP mocetinostat results in increased expression of SCN10A mRNA CTD PMID:27255383 NCBI chr23:8,420,468...8,527,414
Ensembl chr23:8,420,472...8,527,383 		JBrowse link
G SDCBP syndecan binding protein increases expression EXP mocetinostat results in increased expression of SDCBP mRNA CTD PMID:27255383 NCBI chr29:9,331,876...9,370,489 JBrowse link
G SEC24B SEC24 homolog B, COPII coat complex component increases expression EXP mocetinostat results in increased expression of SEC24B mRNA CTD PMID:27255383 NCBI chr32:29,671,702...29,766,628
Ensembl chr32:29,671,738...29,772,192 		JBrowse link
G SEC24D SEC24 homolog D, COPII coat complex component increases expression EXP mocetinostat results in increased expression of SEC24D mRNA CTD PMID:27255383 NCBI chr32:37,690,158...37,795,762
Ensembl chr32:37,690,399...37,924,252 		JBrowse link
G SEC63 SEC63 homolog, protein translocation regulator increases expression EXP mocetinostat results in increased expression of SEC63 mRNA CTD PMID:27255383 NCBI chr12:64,983,442...65,028,573 JBrowse link
G SFT2D1 SFT2 domain containing 1 decreases expression EXP mocetinostat results in decreased expression of SFT2D1 mRNA CTD PMID:27255383 NCBI chr 1:54,335,832...54,354,199
Ensembl chr 1:54,336,005...54,354,137 		JBrowse link
G SMTN smoothelin decreases expression EXP mocetinostat results in decreased expression of SMTN mRNA CTD PMID:27255383 NCBI chr26:24,085,356...24,108,005
Ensembl chr26:24,085,382...24,108,540 		JBrowse link
G SNAP23 synaptosome associated protein 23 increases expression EXP mocetinostat results in increased expression of SNAP23 mRNA CTD PMID:27255383 NCBI chr30:9,453,931...9,493,506
Ensembl chr30:9,456,084...9,492,329 		JBrowse link
G SNAPIN SNAP associated protein decreases expression EXP mocetinostat results in decreased expression of SNAPIN mRNA CTD PMID:27255383 NCBI chr 7:43,410,554...43,411,929
Ensembl chr 7:43,410,998...43,412,323 		JBrowse link
G SNX15 sorting nexin 15 decreases expression EXP mocetinostat results in decreased expression of SNX15 mRNA CTD PMID:27255383 NCBI chr18:52,152,562...52,165,081
Ensembl chr18:52,152,561...52,165,048 		JBrowse link
G SNX16 sorting nexin 16 increases expression EXP mocetinostat results in increased expression of SNX16 mRNA CTD PMID:27255383 NCBI chr29:28,882,768...28,922,713
Ensembl chr29:28,884,426...28,920,797 		JBrowse link
G SNX17 sorting nexin 17 decreases expression EXP mocetinostat results in decreased expression of SNX17 mRNA CTD PMID:27255383 NCBI chr17:21,326,496...21,332,170
Ensembl chr17:21,326,503...21,331,857 		JBrowse link
G SNX24 sorting nexin 24 increases expression EXP mocetinostat results in increased expression of SNX24 mRNA CTD PMID:27255383 NCBI chr11:12,776,934...12,869,304
Ensembl chr11:12,708,712...12,888,165 		JBrowse link
G SNX7 sorting nexin 7 increases expression EXP mocetinostat results in increased expression of SNX7 mRNA CTD PMID:27255383 NCBI chr 6:51,004,307...51,388,283
Ensembl chr 6:51,025,203...51,094,539 		JBrowse link
G SPTBN1 spectrin beta, non-erythrocytic 1 increases expression EXP mocetinostat results in increased expression of SPTBN1 mRNA CTD PMID:27255383 NCBI chr10:55,429,989...55,571,917
Ensembl chr10:55,429,940...55,571,916 		JBrowse link
G STAM2 signal transducing adaptor molecule 2 decreases expression EXP mocetinostat results in decreased expression of STAM2 mRNA CTD PMID:27255383 NCBI chr19:53,213,904...53,256,711
Ensembl chr19:53,216,274...53,256,756
Ensembl chr19:53,216,274...53,256,756 		JBrowse link
G STON1 stonin 1 increases expression EXP mocetinostat results in increased expression of STON1 mRNA CTD PMID:27255383 NCBI chr10:50,421,635...50,470,302
Ensembl chr10:50,436,715...50,467,878 		JBrowse link
G STX4 syntaxin 4 decreases expression EXP mocetinostat results in decreased expression of STX4 mRNA CTD PMID:27255383 NCBI chr 6:17,184,044...17,189,481
Ensembl chr 6:17,184,399...17,189,370 		JBrowse link
G SYTL1 synaptotagmin like 1 increases expression EXP mocetinostat results in increased expression of SYTL1 mRNA CTD PMID:27255383 NCBI chr 2:72,916,445...72,925,219
Ensembl chr 2:72,916,445...72,925,147 		JBrowse link
G SYTL4 synaptotagmin like 4 increases expression EXP mocetinostat results in increased expression of SYTL4 mRNA CTD PMID:27255383 NCBI chr  X:74,537,937...74,617,580
Ensembl chr  X:74,539,183...74,565,753 		JBrowse link
G TFRC transferrin receptor decreases expression EXP mocetinostat results in decreased expression of TFRC mRNA CTD PMID:27255383 NCBI chr33:29,206,024...29,237,221
Ensembl chr33:29,208,609...29,238,242 		JBrowse link
G TMED1 transmembrane p24 trafficking protein 1 decreases expression EXP mocetinostat results in decreased expression of TMED1 mRNA CTD PMID:27255383 NCBI chr20:50,395,862...50,399,118
Ensembl chr20:50,396,005...50,407,535 		JBrowse link
G TMED2 transmembrane p24 trafficking protein 2 decreases expression EXP mocetinostat results in decreased expression of TMED2 mRNA CTD PMID:27255383 NCBI chr26:6,039,046...6,047,490
Ensembl chr26:6,039,405...6,047,459 		JBrowse link
G TRIM54 tripartite motif containing 54 decreases expression EXP mocetinostat results in decreased expression of TRIM54 mRNA CTD PMID:27255383 NCBI chr17:21,257,660...21,278,410
Ensembl chr17:21,257,706...21,278,274 		JBrowse link
G TSG101 tumor susceptibility 101 decreases expression EXP mocetinostat results in decreased expression of TSG101 mRNA CTD PMID:27255383 NCBI chr21:40,910,870...40,952,922
Ensembl chr21:40,910,874...40,952,808 		JBrowse link
G TTN titin decreases expression EXP mocetinostat results in decreased expression of TTN mRNA CTD PMID:27255383 NCBI chr36:22,146,870...22,417,858
Ensembl chr36:22,147,824...22,417,826 		JBrowse link
G TUBA4A tubulin alpha 4a decreases expression EXP mocetinostat results in decreased expression of TUBA4A mRNA CTD PMID:27255383 NCBI chr37:25,799,075...25,803,257
Ensembl chr37:25,796,107...25,802,892 		JBrowse link
G TUBG1 tubulin, gamma 1 decreases expression EXP mocetinostat results in decreased expression of TUBG1 mRNA CTD PMID:27255383 NCBI chr 9:20,358,683...20,363,455
Ensembl chr 9:20,322,253...20,363,455 		JBrowse link
G USO1 USO1 vesicle transport factor decreases expression EXP mocetinostat results in decreased expression of USO1 mRNA CTD PMID:27255383 NCBI chr32:305,895...395,113
Ensembl chr32:305,935...394,896 		JBrowse link
G VPS13B vacuolar protein sorting 13 homolog B decreases expression EXP mocetinostat results in decreased expression of VPS13B mRNA CTD PMID:27255383 NCBI chr13:1,101,226...1,834,933
Ensembl chr13:1,101,610...1,871,225 		JBrowse link
G VPS16 VPS16 core subunit of CORVET and HOPS complexes decreases expression EXP mocetinostat results in decreased expression of VPS16 mRNA CTD PMID:27255383 NCBI chr24:18,401,440...18,424,605
Ensembl chr24:18,399,572...18,424,510 		JBrowse link
G VPS26A VPS26, retromer complex component A decreases expression EXP mocetinostat results in decreased expression of VPS26A mRNA CTD PMID:27255383 NCBI chr 4:20,265,120...20,296,125
Ensembl chr 4:20,264,905...20,294,674 		JBrowse link
G VPS29 VPS29 retromer complex component decreases expression EXP mocetinostat results in decreased expression of VPS29 mRNA CTD PMID:27255383 NCBI chr26:8,301,699...8,309,364
Ensembl chr26:8,301,699...8,309,364 		JBrowse link
G VPS33A VPS33A core subunit of CORVET and HOPS complexes decreases expression EXP mocetinostat results in decreased expression of VPS33A mRNA CTD PMID:27255383 NCBI chr26:7,090,669...7,119,913 JBrowse link
G VPS33B VPS33B late endosome and lysosome associated decreases expression EXP mocetinostat results in decreased expression of VPS33B mRNA CTD PMID:27255383 NCBI chr 3:53,220,199...53,239,738
Ensembl chr 3:53,220,194...53,239,732 		JBrowse link
G VPS35 VPS35 retromer complex component decreases expression EXP mocetinostat results in decreased expression of VPS35 mRNA CTD PMID:27255383 NCBI chr15:8,428,073...8,454,601
Ensembl chr15:8,428,172...8,454,049 		JBrowse link
G VPS41 VPS41 subunit of HOPS complex decreases expression EXP mocetinostat results in decreased expression of VPS41 mRNA CTD PMID:27255383 NCBI chr18:10,788,846...10,956,207
Ensembl chr18:10,788,891...10,955,645 		JBrowse link
G VPS52 VPS52 subunit of GARP complex decreases expression EXP mocetinostat results in decreased expression of VPS52 mRNA CTD PMID:27255383 NCBI chr12:2,697,508...2,712,831
Ensembl chr12:2,697,508...2,712,831 		JBrowse link
G VPS54 VPS54 subunit of GARP complex increases expression EXP mocetinostat results in increased expression of VPS54 mRNA CTD PMID:27255383 NCBI chr10:63,598,373...63,676,753
Ensembl chr10:63,599,229...63,676,747 		JBrowse link
G VTI1B vesicle transport through interaction with t-SNAREs 1B decreases expression EXP mocetinostat results in decreased expression of VTI1B mRNA CTD PMID:27255383 NCBI chr 8:41,619,365...41,650,389
Ensembl chr29:19,153,616...19,154,245
Ensembl chr 8:19,153,616...19,154,245 		JBrowse link
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL6 interleukin 6 multiple interactions
decreases expression		 EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of IL6 protein]
N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide results in decreased expression of IL6 protein		 CTD PMID:24105867 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G PRKACB protein kinase cAMP-activated catalytic subunit beta multiple interactions EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Amphotericin B results in increased expression of PRKACG protein] CTD PMID:24105867 NCBI chr 6:63,615,445...63,729,386
Ensembl chr 6:63,618,323...63,730,146 		JBrowse link
N-acetyl-L-cysteine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] CTD PMID:23816505 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:23816505 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Acetylcysteine inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119 		JBrowse link
N-nitrosodimethylamine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GJA1 gap junction protein alpha 1 decreases expression EXP Dimethylnitrosamine results in decreased expression of GJA1 protein CTD PMID:15736408 NCBI chr 1:60,941,772...60,944,694
Ensembl chr 1:60,929,097...60,942,936 		JBrowse link
Naftopidil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA1D adrenoceptor alpha 1D multiple interactions EXP naftopidil binds to and results in decreased activity of ADRA1D protein; naftopidil inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein] CTD PMID:19371927 NCBI chr24:17,231,771...17,239,110
Ensembl chr24:17,213,643...17,214,761
Ensembl chr24:17,213,643...17,214,761 		JBrowse link
Nalmefene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POMC proopiomelanocortin increases expression EXP nalmefene results in increased expression of POMC protein alternative form CTD PMID:3026683 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440 		JBrowse link
naloxone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G POMC proopiomelanocortin increases expression EXP Naloxone results in increased expression of POMC protein CTD PMID:8277081 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440 		JBrowse link
nefiracetam term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 affects expression
increases expression		 EXP nefiracetam affects the expression of PTGS2 mRNA
nefiracetam results in increased expression of PTGS2 protein		 CTD PMID:16105799 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903 		JBrowse link
nicotinamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPARG peroxisome proliferator activated receptor gamma increases expression
multiple interactions		 EXP Niacinamide results in increased expression of PPARG protein
Resveratrol inhibits the reaction [Niacinamide results in increased expression of PPARG protein]		 CTD PMID:22539994 NCBI chr20:6,134,618...6,265,481
Ensembl chr20:6,050,357...6,207,981 		JBrowse link
G RUNX2 RUNX family transcription factor 2 increases acetylation
multiple interactions
decreases expression		 EXP Niacinamide results in increased acetylation of RUNX2 protein
Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide results in increased acetylation of RUNX2 protein]		 CTD PMID:22539994 NCBI chr12:13,723,535...13,842,565
Ensembl chr12:13,628,539...13,840,785
Ensembl chr12:13,628,539...13,840,785 		JBrowse link
G SIRT1 sirtuin 1 multiple interactions
decreases expression		 EXP Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]; Resveratrol inhibits the reaction [Niacinamide inhibits the reaction [SIRT1 protein binds to RUNX2 protein]]; Resveratrol inhibits the reaction [Niacinamide results in decreased expression of SIRT1 protein] CTD PMID:22539994 NCBI chr 4:19,188,616...19,220,031
Ensembl chr 4:19,188,675...19,218,279 		JBrowse link
nimesulide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G IL1B interleukin 1 beta decreases expression EXP nimesulide results in decreased expression of IL1B mRNA CTD PMID:19638440 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP nimesulide results in decreased expression of PTGS2 mRNA CTD PMID:15198222 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903 		JBrowse link
nitric oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNG1 kininogen 1 increases activity EXP Nitric Oxide deficiency results in increased activity of KNG1 protein modified form CTD PMID:10805402 NCBI chr34:19,288,629...19,318,096
Ensembl chr34:19,287,109...19,318,081 		JBrowse link
G WT1 WT1 transcription factor multiple interactions EXP [Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA CTD PMID:21443142 NCBI chr18:35,099,660...35,148,767
Ensembl chr18:35,103,934...35,148,000 		JBrowse link
nitrites term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNG1 kininogen 1 increases chemical synthesis EXP KNG1 protein modified form results in increased chemical synthesis of Nitrites CTD PMID:17644579 NCBI chr34:19,288,629...19,318,096
Ensembl chr34:19,287,109...19,318,081 		JBrowse link
nitroglycerin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin decreases activity EXP Nitroglycerin results in decreased activity of REN protein CTD PMID:8640982 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
NS-398 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of PTGS2 mRNA; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of PTGS2 protein CTD PMID:12857884 PMID:15198222 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases localization EXP N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased localization of RELA protein CTD PMID:12857884 NCBI chr18:51,550,003...51,558,861
Ensembl chr18:51,550,040...51,558,875 		JBrowse link
ochratoxin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACTA2 actin alpha 2, smooth muscle multiple interactions
increases expression		 EXP CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of ACTA2 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]
ochratoxin A results in increased expression of ACTA2 mRNA; ochratoxin A results in increased expression of ACTA2 protein		 CTD PMID:33543323 NCBI chr26:38,700,434...38,714,915
Ensembl chr26:38,700,480...38,711,753 		JBrowse link
G B9D2 B9 domain containing 2 multiple interactions
increases expression		 EXP CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of TGFB1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]
ochratoxin A results in increased expression of TGFB1 mRNA; ochratoxin A results in increased expression of TGFB1 protein		 CTD PMID:33543323 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885 		JBrowse link
G CASP4 caspase 4, apoptosis-related cysteine peptidase multiple interactions
increases expression
increases cleavage		 EXP CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of CASP1 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased cleavage of CASP1 protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of CASP1 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of CASP1 mRNA] CTD PMID:33543323 NCBI chr 5:27,133,778...27,147,954
Ensembl chr 5:27,132,565...27,149,736 		JBrowse link
G GSDMD gasdermin D multiple interactions
increases expression		 EXP CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of GSDMD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]
ochratoxin A results in increased expression of GSDMD mRNA; ochratoxin A results in increased expression of GSDMD protein		 CTD PMID:33543323 NCBI chr13:37,221,219...37,226,912
Ensembl chr13:37,193,022...37,228,360 		JBrowse link
G IL18 interleukin 18 increases expression
multiple interactions		 EXP ochratoxin A results in increased expression of IL18 mRNA
CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL18 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]		 CTD PMID:33543323 NCBI chr 5:20,972,742...20,995,327
Ensembl chr 5:20,972,871...20,995,348 		JBrowse link
G IL1B interleukin 1 beta increases expression
multiple interactions		 EXP ochratoxin A results in increased expression of IL1B mRNA; ochratoxin A results in increased expression of IL1B protein
CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL1B mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of IL1B protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]		 CTD PMID:33543323 NCBI chr17:37,019,329...37,033,388
Ensembl chr17:37,019,329...37,024,458 		JBrowse link
G IL6 interleukin 6 increases secretion
increases expression		 EXP ochratoxin A results in increased secretion of IL6 protein
ochratoxin A results in increased expression of IL6 mRNA		 CTD PMID:33543323 NCBI chr14:36,474,268...36,478,519
Ensembl chr14:36,473,394...36,478,519 		JBrowse link
G NLRP3 NLR family pyrin domain containing 3 multiple interactions
increases expression		 EXP N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of NLRP3 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased cleavage of CASP1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of ACTA2 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of CASP1 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of GSDMD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL18 mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of IL1B protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of TGFB1 protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]
ochratoxin A results in increased expression of NLRP3 mRNA; ochratoxin A results in increased expression of NLRP3 protein		 CTD PMID:33543323 NCBI chr 8:251,776...313,290
Ensembl chr 8:253,407...313,059 		JBrowse link
G PYCARD PYD and CARD domain containing increases expression
multiple interactions		 EXP ochratoxin A results in increased expression of PYCARD mRNA; ochratoxin A results in increased expression of PYCARD protein
N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of PYCARD protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD mRNA]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of PYCARD protein]		 CTD PMID:33543323 NCBI chr 6:17,049,352...17,051,348
Ensembl chr 6:17,049,705...17,051,240 		JBrowse link
G TNF tumor necrosis factor increases secretion
increases expression		 EXP ochratoxin A results in increased secretion of TNF protein
ochratoxin A results in increased expression of TNF mRNA		 CTD PMID:33543323 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
G VIM vimentin multiple interactions
increases expression		 EXP CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM mRNA]; CASP1 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]; N-(1,2,3,5,6,7-hexahydro-S-indacen-4-ylcarbamoyl)-4-(2-hydroxy-2-propanyl)-2-furansulfonamide inhibits the reaction [ochratoxin A results in increased expression of VIM protein]; NLRP3 protein affects the reaction [ochratoxin A results in increased expression of VIM protein]
ochratoxin A results in increased expression of VIM mRNA; ochratoxin A results in increased expression of VIM protein		 CTD PMID:33543323 NCBI chr 2:19,671,316...19,679,367
Ensembl chr 2:19,671,316...19,679,466 		JBrowse link
ofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CAPN1 calpain 1 increases expression EXP Ofloxacin results in increased expression of CAPN1 mRNA CTD PMID:24582689 NCBI chr18:51,983,266...52,010,831
Ensembl chr18:51,983,824...52,010,757 		JBrowse link
G CASP12 caspase 12 increases expression EXP Ofloxacin results in increased expression of CASP12 mRNA; Ofloxacin results in increased expression of CASP12 protein CTD PMID:24582689 NCBI chr 5:27,162,840...27,176,964
Ensembl chr 5:27,161,700...27,177,683 		JBrowse link
G CASP8 caspase 8 multiple interactions
increases expression		 EXP TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA] CTD PMID:24582689 NCBI chr37:10,362,071...10,402,108
Ensembl chr37:10,391,048...10,401,822 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression EXP Ofloxacin results in increased expression of DDIT3 mRNA CTD PMID:24582689 NCBI chr10:1,606,693...1,612,410
Ensembl chr10:1,606,693...1,611,303 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Ofloxacin results in increased expression of HSPA5 mRNA CTD PMID:24582689 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257 		JBrowse link
G TNF tumor necrosis factor increases expression EXP Ofloxacin results in increased expression of TNF mRNA; Ofloxacin results in increased expression of TNF protein CTD PMID:24582689 NCBI chr12:1,074,561...1,076,425
Ensembl chr12:1,074,552...1,076,425 		JBrowse link
G TNFRSF1A TNF receptor superfamily member 1A multiple interactions
increases expression		 EXP TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of CASP8 mRNA]; TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA]
Ofloxacin results in increased expression of TNFRSF1A mRNA; Ofloxacin results in increased expression of TNFRSF1A protein		 CTD PMID:24582689 NCBI chr27:38,641,837...38,654,693
Ensembl chr27:38,638,753...38,700,282 		JBrowse link
G TRADD TNFRSF1A associated via death domain increases expression
multiple interactions		 EXP Ofloxacin results in increased expression of TRADD mRNA
TNFRSF1A mutant form inhibits the reaction [Ofloxacin results in increased expression of TRADD mRNA]		 CTD PMID:24582689 NCBI chr 5:82,200,430...82,211,430
Ensembl chr 5:82,206,111...82,210,963 		JBrowse link
omeprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Omeprazole results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
G SLC22A6 solute carrier family 22 member 6 multiple interactions EXP [Omeprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr18:53,736,669...53,745,001
Ensembl chr18:53,736,959...53,744,396 		JBrowse link
pantoprazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A6 solute carrier family 22 member 6 multiple interactions EXP [Pantoprazole results in decreased activity of SLC22A6 protein] which results in decreased uptake of Indican CTD PMID:36243147 NCBI chr18:53,736,669...53,745,001
Ensembl chr18:53,736,959...53,744,396 		JBrowse link
paracetamol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Acetaminophen results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
G UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 increases glucuronidation EXP UGT1A6 protein results in increased glucuronidation of Acetaminophen CTD PMID:11903872 NCBI chr25:45,081,655...45,161,584
Ensembl chr25:45,032,130...45,160,941 		JBrowse link
paraoxon term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase decreases activity EXP Paraoxon results in decreased activity of BCHE protein CTD PMID:4631366 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583 		JBrowse link
penconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A2 solute carrier family 22 member 2 decreases activity EXP penconazole results in decreased activity of SLC22A2 protein CTD PMID:36669674 NCBI chr 1:49,327,621...49,348,435
Ensembl chr 1:49,327,296...49,348,435 		JBrowse link
G SLC22A5 solute carrier family 22 member 5 decreases activity EXP penconazole results in decreased activity of SLC22A5 protein CTD PMID:36669674 NCBI chr11:20,659,023...20,686,359
Ensembl chr11:20,598,888...20,683,087 		JBrowse link
G SLC47A1 solute carrier family 47 member 1 decreases activity EXP penconazole results in decreased activity of SLC47A1 protein CTD PMID:36669674 NCBI chr 5:40,643,420...40,679,130
Ensembl chr 5:40,642,784...40,679,946 		JBrowse link
G SLC47A2 solute carrier family 47 member 2 decreases activity EXP penconazole results in decreased activity of SLC47A2 protein CTD PMID:36669674 NCBI chr 5:40,491,306...40,515,430
Ensembl chr 5:40,491,933...40,540,136 		JBrowse link
pentobarbital term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin increases activity EXP Pentobarbital results in increased activity of REN protein CTD PMID:6348358 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
phalloidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G TJP1 tight junction protein 1 multiple interactions EXP Phalloidine inhibits the reaction [Calcium Oxalate results in decreased expression of TJP1 protein] CTD PMID:34147488 NCBI chr 3:38,997,122...39,076,617
Ensembl chr 3:38,997,076...39,241,574 		JBrowse link
phenacetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 affects metabolic processing EXP CYP1A2 protein affects the metabolism of Phenacetin CTD PMID:15801540 NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135 		JBrowse link
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Phenacetin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819 		JBrowse link
phenobarbital term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACAA1 acetyl-CoA acyltransferase 1 decreases expression EXP Phenobarbital results in decreased expression of ACAA1 mRNA CTD PMID:19952500 NCBI chr23:7,889,481...7,901,324
Ensembl chr23:7,889,500...7,901,229 		JBrowse link
G ACAA2 acetyl-CoA acyltransferase 2 decreases expression EXP Phenobarbital results in decreased expression of ACAA2 mRNA CTD PMID:19952500 NCBI chr 7:79,028,636...79,057,720 JBrowse link
G ACOX2 acyl-CoA oxidase 2 decreases expression EXP Phenobarbital results in decreased expression of ACOX2 mRNA CTD PMID:19952500 NCBI chr20:32,110,788...32,141,751
Ensembl chr20:32,113,217...32,141,734 		JBrowse link
G AGXT alanine--glyoxylate and serine--pyruvate aminotransferase decreases expression EXP Phenobarbital results in decreased expression of AGXT protein CTD PMID:19952500 NCBI chr25:50,968,291...50,976,089 JBrowse link
G AHCY adenosylhomocysteinase decreases expression EXP Phenobarbital results in decreased expression of AHCY protein CTD PMID:19952500 NCBI chr24:23,410,553...23,423,494
Ensembl chr24:23,411,140...23,419,767 		JBrowse link
G ASL argininosuccinate lyase decreases expression EXP Phenobarbital results in decreased expression of ASL protein CTD PMID:19952500 NCBI chr 6:768,522...779,144
Ensembl chr 6:730,358...779,424 		JBrowse link
G ASS1 argininosuccinate synthase 1 decreases expression EXP Phenobarbital results in decreased expression of ASS1 protein CTD PMID:19952500 NCBI chr 9:53,425,228...53,478,007
Ensembl chr 9:53,425,448...53,477,904 		JBrowse link
G BHMT betaine--homocysteine S-methyltransferase decreases expression EXP Phenobarbital results in decreased expression of BHMT protein CTD PMID:19952500 NCBI chr 3:27,732,381...27,752,168
Ensembl chr 3:27,734,108...27,752,046 		JBrowse link
G CA3 carbonic anhydrase 3 decreases expression EXP Phenobarbital results in decreased expression of CA3 protein CTD PMID:19952500 NCBI chr29:31,935,192...31,945,585
Ensembl chr29:31,935,172...31,980,579 		JBrowse link
G CPT1A carnitine palmitoyltransferase 1A decreases expression EXP Phenobarbital results in decreased expression of CPT1A mRNA CTD PMID:19952500 NCBI chr18:49,136,691...49,190,117
Ensembl chr18:49,136,691...49,190,117 		JBrowse link
G CRYZ crystallin zeta increases expression EXP Phenobarbital results in increased expression of CRYZ protein CTD PMID:19952500 NCBI chr 6:71,656,162...71,693,020
Ensembl chr 6:71,656,188...71,675,692 		JBrowse link
G CYP1A2 cytochrome P450 family 1 subfamily A member 2 decreases expression EXP Phenobarbital results in decreased expression of CYP1A2 mRNA CTD PMID:19952500 NCBI chr30:37,818,400...37,824,192
Ensembl chr30:37,799,140...37,824,135 		JBrowse link
G CYP2A13 cytochrome P450 family 2 subfamily A polypeptide 13 decreases expression EXP Phenobarbital results in decreased expression of CYP2A13 mRNA CTD PMID:19952500 NCBI chr 1:112,932,246...112,938,248
Ensembl chr 1:112,931,985...112,938,350 		JBrowse link
G CYP2B6 cytochrome P450 2B11 increases expression EXP Phenobarbital results in increased expression of CYP2B6 protein CTD PMID:19952500 NCBI chr 1:112,817,561...112,833,294
Ensembl chr 1:112,816,502...112,833,293 		JBrowse link
G CYP2E1 cytochrome P450 family 2 subfamily E member 1 decreases expression EXP Phenobarbital results in decreased expression of CYP2E1 mRNA CTD PMID:19952500 NCBI chr28:41,079,164...41,089,188
Ensembl chr28:41,035,025...41,122,754 		JBrowse link
G CYP3A12 cytochrome P-450 3A12 increases expression EXP Phenobarbital results in increased expression of CYP3A12 protein CTD PMID:19952500
G CYP3A26 cytochrome P450 3A26 increases expression EXP Phenobarbital results in increased expression of CYP3A26 mRNA CTD PMID:19952500 NCBI chr 6:9,777,663...9,815,345
Ensembl chr 6:9,777,659...9,869,352 		JBrowse link
G CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 increases expression EXP Phenobarbital results in increased expression of CYP3A4 mRNA CTD PMID:19952500 NCBI chr 6:9,836,685...9,869,520
Ensembl chr 6:9,777,659...9,869,352 		JBrowse link
G CYP4A37 cytochrome P450 4A37 decreases expression EXP Phenobarbital results in decreased expression of CYP4A11 mRNA CTD PMID:19952500 NCBI chr15:13,604,130...13,623,797 JBrowse link
G EHHADH enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase decreases expression EXP Phenobarbital results in decreased expression of EHHADH mRNA CTD PMID:19952500 NCBI chr34:18,021,047...18,080,993
Ensembl chr34:18,022,353...18,080,903 		JBrowse link
G FTCD formimidoyltransferase cyclodeaminase increases expression EXP Phenobarbital results in increased expression of FTCD protein CTD PMID:19952500 NCBI chr31:39,451,557...39,464,249
Ensembl chr31:39,275,159...39,464,715 		JBrowse link
G GOT1 glutamic-oxaloacetic transaminase 1 decreases expression EXP Phenobarbital results in decreased expression of GOT1 protein CTD PMID:19952500 NCBI chr28:12,352,658...12,377,960
Ensembl chr28:12,352,659...12,414,579 		JBrowse link
G GSTA4 glutathione S-transferase alpha 4 decreases expression EXP Phenobarbital results in decreased expression of GSTA4 mRNA CTD PMID:19952500 NCBI chr12:20,426,724...20,443,200
Ensembl chr12:20,426,726...20,443,200 		JBrowse link
G GSTO1 glutathione S-transferase omega 1 increases expression EXP Phenobarbital results in increased expression of GSTO1 mRNA CTD PMID:19952500 NCBI chr28:16,569,421...16,579,239
Ensembl chr28:16,569,066...16,619,880 		JBrowse link
G GSTT2B glutathione S-transferase theta 2B decreases expression EXP Phenobarbital results in decreased expression of GSTT2 mRNA CTD PMID:19952500 NCBI chr26:28,573,435...28,580,846 JBrowse link
G HADH hydroxyacyl-CoA dehydrogenase decreases expression EXP Phenobarbital results in decreased expression of HADH mRNA CTD PMID:19952500 NCBI chr32:28,460,445...28,506,141
Ensembl chr32:28,460,193...28,531,280 		JBrowse link
G HPD 4-hydroxyphenylpyruvate dioxygenase decreases expression EXP Phenobarbital results in decreased expression of HPD protein CTD PMID:19952500 NCBI chr26:7,430,891...7,440,643
Ensembl chr26:7,430,933...7,440,611 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Phenobarbital results in increased expression of HSPA5 protein CTD PMID:19952500 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257 		JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 decreases expression EXP Phenobarbital results in decreased expression of IDH1 protein CTD PMID:19952500 NCBI chr37:16,512,027...16,531,269
Ensembl chr37:16,512,770...16,531,219 		JBrowse link
G LOC474938 glutathione S-transferase A2 increases expression EXP Phenobarbital results in increased expression of GSTA3 protein CTD PMID:19952500 NCBI chr12:20,349,133...20,365,023 JBrowse link
G LOC477540 SEC14-like protein 3 decreases expression EXP Phenobarbital results in decreased expression of SEC14L3 protein CTD PMID:19952500 NCBI chr26:23,580,899...23,590,676
Ensembl chr26:23,580,901...23,590,622 		JBrowse link
G LOC486353 SEC14-like protein 4 decreases expression EXP Phenobarbital results in decreased expression of SEC14L4 protein CTD PMID:19952500 NCBI chr26:23,598,434...23,611,727
Ensembl chr26:23,600,237...23,618,123 		JBrowse link
G MGST1 microsomal glutathione S-transferase 1 increases expression EXP Phenobarbital results in increased expression of MGST1 mRNA CTD PMID:19952500 NCBI chr27:30,370,588...30,391,898
Ensembl chr27:30,370,594...30,391,778 		JBrowse link
G MGST2 microsomal glutathione S-transferase 2 increases expression EXP Phenobarbital results in increased expression of MGST2 mRNA CTD PMID:19952500 NCBI chr19:3,067,062...3,070,579 JBrowse link
G MGST3 microsomal glutathione S-transferase 3 decreases expression EXP Phenobarbital results in decreased expression of MGST3 mRNA CTD PMID:19952500 NCBI chr38:17,670,329...17,691,822
Ensembl chr38:17,668,752...17,718,704 		JBrowse link
G PAH phenylalanine hydroxylase decreases expression EXP Phenobarbital results in decreased expression of PAH protein CTD PMID:19952500 NCBI chr15:41,590,253...41,670,156
Ensembl chr15:41,592,876...41,670,837 		JBrowse link
G PDIA3 protein disulfide isomerase family A member 3 increases expression EXP Phenobarbital results in increased expression of PDIA3 protein CTD PMID:19952500 NCBI chr30:10,487,926...10,513,437
Ensembl chr30:10,487,921...10,513,397 		JBrowse link
G PRDX6 peroxiredoxin 6 decreases expression EXP Phenobarbital results in decreased expression of PRDX6 protein CTD PMID:19952500 NCBI chr 7:25,663,238...25,675,855
Ensembl chr 7:25,663,579...25,675,754 		JBrowse link
G SELENBP1 selenium binding protein 1 decreases expression EXP Phenobarbital results in decreased expression of SELENBP1 protein CTD PMID:19952500 NCBI chr17:60,410,727...60,418,770
Ensembl chr17:60,410,734...60,418,704 		JBrowse link
G SOD1 superoxide dismutase 1 affects response to substance EXP SOD1 protein affects the susceptibility to Phenobarbital CTD PMID:6333936 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815 		JBrowse link
G UGDH UDP-glucose 6-dehydrogenase increases expression EXP Phenobarbital results in increased expression of UGDH protein CTD PMID:19952500 NCBI chr 3:72,935,532...72,964,151
Ensembl chr 3:72,839,920...72,963,208 		JBrowse link
G UGT2B31 UDP-glucuronosyltransferase UGT2B31 increases expression EXP Phenobarbital results in increased expression of UGT2B4 protein CTD PMID:19952500 NCBI chr13:58,993,957...59,007,420 JBrowse link
G UROC1 urocanate hydratase 1 decreases expression EXP Phenobarbital results in decreased expression of UROC1 protein CTD PMID:19952500 NCBI chr20:676,624...717,109
Ensembl chr20:678,073...717,141 		JBrowse link
phenylephrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA1A adrenoceptor alpha 1A multiple interactions EXP Phenylephrine binds to and results in increased activity of ADRA1A protein; silodosin inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:19371927 NCBI chr25:30,690,959...30,801,484
Ensembl chr25:30,693,571...30,801,486 		JBrowse link
G ADRA1D adrenoceptor alpha 1D multiple interactions EXP BMY 7378 inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein]; naftopidil inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1D protein]; Phenylephrine binds to and results in increased activity of ADRA1D protein CTD PMID:19371927 NCBI chr24:17,231,771...17,239,110
Ensembl chr24:17,213,643...17,214,761
Ensembl chr24:17,213,643...17,214,761 		JBrowse link
G REN renin increases secretion EXP Phenylephrine results in increased secretion of REN protein CTD PMID:6347479 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
phosphatidylinositol 3-phosphate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; [Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; [Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate; Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
phosphoryl trichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase decreases activity EXP phosphoryl chloride results in decreased activity of BCHE protein CTD PMID:12641435 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583 		JBrowse link
pindolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin multiple interactions EXP Pindolol inhibits the reaction [Isoproterenol results in increased activity of REN protein] CTD PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
pitavastatin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NCF1 neutrophil cytosolic factor 1 decreases expression EXP pitavastatin results in decreased expression of NCF1 mRNA CTD PMID:15502390 NCBI chr 6:5,702,222...5,719,515
Ensembl chr 6:5,605,694...5,719,458 		JBrowse link
G NOS3 nitric oxide synthase 3 increases expression
increases activity		 EXP pitavastatin results in increased expression of NOS3 mRNA
pitavastatin results in increased activity of NOS3 protein		 CTD PMID:15502390 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277 		JBrowse link
G NOX4 NADPH oxidase 4 decreases expression EXP pitavastatin results in decreased expression of NOX4 mRNA CTD PMID:15502390 NCBI chr21:10,615,153...10,782,927
Ensembl chr21:10,615,970...10,775,277 		JBrowse link
prochloraz term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444 		JBrowse link
G CYP1A1 cytochrome P450 family 1 subfamily A member 1 multiple interactions EXP [prochloraz binds to and results in increased activity of AHR protein] which results in increased activity of CYP1A1 protein CTD PMID:24389113 NCBI chr30:37,793,277...37,799,535
Ensembl chr30:37,793,508...37,796,866 		JBrowse link
propranolol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB2 adrenoceptor beta 2 multiple interactions EXP [Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine CTD PMID:2884805 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298 		JBrowse link
G NPPA natriuretic peptide A increases expression EXP Propranolol results in increased expression of NPPA protein CTD PMID:2566282 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385 		JBrowse link
G REN renin multiple interactions
decreases activity		 EXP Propranolol inhibits the reaction [Isoproterenol results in increased activity of REN protein]
Propranolol results in decreased activity of REN protein		 CTD PMID:2566282 PMID:6103674 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
G VIP vasoactive intestinal peptide decreases expression EXP Propranolol results in decreased expression of VIP protein CTD PMID:2566282 NCBI chr 1:42,941,655...42,950,160
Ensembl chr 1:42,941,224...42,950,700 		JBrowse link
pyridines term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DRD2 dopamine receptor D2 multiple interactions EXP Pyridines analog binds to and results in decreased activity of DRD2 protein CTD PMID:12593651 NCBI chr 5:19,732,842...19,795,241
Ensembl chr 5:19,732,836...19,795,241 		JBrowse link
quinacrine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions EXP Quinacrine promotes the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417 		JBrowse link
ranolazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATP2A2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 affects expression
multiple interactions		 EXP Ranolazine affects the expression of ATP2A2 protein
[Ranolazine co-treated with Enalapril] affects the expression of ATP2A2 protein; [Ranolazine co-treated with Metoprolol] affects the expression of ATP2A2 protein		 CTD PMID:18820026 NCBI chr26:8,148,181...8,209,392
Ensembl chr26:8,148,236...8,209,388 		JBrowse link
G EGR1 early growth response 1 multiple interactions
affects expression		 EXP [Ranolazine co-treated with Enalapril] affects the expression of EGR1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of EGR1 protein
Ranolazine affects the expression of EGR1 protein		 CTD PMID:18820026 NCBI chr11:26,046,195...26,049,806
Ensembl chr11:26,046,228...26,048,575 		JBrowse link
G GATA4 GATA binding protein 4 multiple interactions
affects expression		 EXP [Ranolazine co-treated with Enalapril] affects the expression of GATA4 protein; [Ranolazine co-treated with Metoprolol] affects the expression of GATA4 protein
Ranolazine affects the expression of GATA4 protein		 CTD PMID:18820026 NCBI chr25:26,126,172...26,211,474
Ensembl chr25:26,127,853...26,182,989 		JBrowse link
G NAB1 NGFI-A binding protein 1 multiple interactions
affects expression		 EXP [Ranolazine co-treated with Enalapril] affects the expression of NAB1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of NAB1 protein
Ranolazine affects the expression of NAB1 protein		 CTD PMID:18820026 NCBI chr37:1,207,619...1,243,546
Ensembl chr37:1,207,638...1,241,610 		JBrowse link
G SLC8A1 solute carrier family 8 member A1 multiple interactions
affects expression		 EXP [Ranolazine co-treated with Enalapril] affects the expression of SLC8A1 protein; [Ranolazine co-treated with Metoprolol] affects the expression of SLC8A1 protein
Ranolazine affects the expression of SLC8A1 protein		 CTD PMID:18820026 NCBI chr17:32,004,207...32,381,399
Ensembl chr17:32,005,245...32,307,700 		JBrowse link
rifampicin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 increases expression EXP Rifampin results in increased expression of ABCB1 mRNA; Rifampin results in increased expression of ABCB1 protein CTD PMID:22620706 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Rifampin results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
Rilmenidine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin decreases activity EXP Rilmenidine results in decreased activity of REN protein CTD PMID:2866274 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012 		JBrowse link
risperidone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DRD2 dopamine receptor D2 multiple interactions EXP Risperidone binds to and results in decreased activity of DRD2 protein CTD PMID:16948927 NCBI chr 5:19,732,842...19,795,241
Ensembl chr 5:19,732,836...19,795,241 		JBrowse link
ritonavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP allicin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; hypericin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; kaempferol inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir]; Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] CTD PMID:15266218 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G NR1I2 nuclear receptor subfamily 1 group I member 2 increases activity EXP Ritonavir results in increased activity of NR1I2 protein CTD PMID:27732639 NCBI chr33:23,444,367...23,456,405
Ensembl chr33:23,432,690...23,455,347 		JBrowse link
salicylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444 		JBrowse link
saquinavir term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 protein affects the transport of Saquinavir CTD PMID:12702717 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740 		JBrowse link
SDZ PSC 833 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Doxorubicin]; valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine]; valspodar inhibits the reaction [ABCB1 protein results in decreased susceptibility to Doxorubicin] CTD PMID:15492788 PMID:24975508 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
serotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen multiple interactions
increases response to substance		 EXP Deferoxamine inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin]; Reactive Oxygen Species inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin] CTD PMID:8021468 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880 		JBrowse link
G EDN1 endothelin 1 increases activity EXP Serotonin results in increased activity of EDN1 protein CTD PMID:9918753 NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383 		JBrowse link
silodosin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRA1A adrenoceptor alpha 1A multiple interactions EXP silodosin binds to and results in decreased activity of ADRA1A protein; silodosin inhibits the reaction [Phenylephrine binds to and results in increased activity of ADRA1A protein] CTD PMID:19371927 NCBI chr25:30,690,959...30,801,484
Ensembl chr25:30,693,571...30,801,486 		JBrowse link
sincalide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B2 solute carrier organic anion transporter family member 1B2 increases transport EXP SLCO1B3 protein results in increased transport of Sincalide CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989 		JBrowse link
sodium arsenite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSR glutathione-disulfide reductase decreases activity
multiple interactions		 EXP sodium arsenite results in decreased activity of GSR protein
[monoisoamyl-2,3-dimercaptosuccinate co-treated with Succimer] inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]; monoisoamyl-2,3-dimercaptosuccinate inhibits the reaction [sodium arsenite results in decreased activity of GSR protein]		 CTD PMID:18163546 NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752 		JBrowse link
G HSP70 heat shock protein 70 increases expression
multiple interactions		 EXP sodium arsenite results in increased expression of HSP70 protein
carvacrol promotes the reaction [sodium arsenite results in increased expression of HSP70 protein]; leucinostatin A promotes the reaction [sodium arsenite results in increased expression of HSP70 protein]		 CTD PMID:31940135 NCBI chr12:1,285,282...1,287,670 JBrowse link
Soman term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions
decreases activity		 EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702 		JBrowse link
G BCHE butyrylcholinesterase decreases activity EXP Soman results in decreased activity of BCHE protein CTD PMID:16915560 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583 		JBrowse link
SR 144528 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNR2 cannabinoid receptor 2 multiple interactions EXP SR 144528 binds to and results in decreased activity of CNR2 protein CTD PMID:21871882 NCBI chr 2:75,640,636...75,662,000
Ensembl chr 2:75,658,999...75,660,126 		JBrowse link
succinylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCHE butyrylcholinesterase increases hydrolysis
multiple interactions		 EXP BCHE protein results in increased hydrolysis of Succinylcholine
Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]		 CTD PMID:4985882 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583 		JBrowse link
taurocholic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B2 solute carrier organic anion transporter family member 1B2 increases transport EXP SLCO1B3 protein results in increased transport of Taurocholic Acid CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989 		JBrowse link
tebuconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A2 solute carrier family 22 member 2 decreases activity EXP tebuconazole results in decreased activity of SLC22A2 protein CTD PMID:36669674 NCBI chr 1:49,327,621...49,348,435
Ensembl chr 1:49,327,296...49,348,435 		JBrowse link
G SLC22A5 solute carrier family 22 member 5 decreases activity EXP tebuconazole results in decreased activity of SLC22A5 protein CTD PMID:36669674 NCBI chr11:20,659,023...20,686,359
Ensembl chr11:20,598,888...20,683,087 		JBrowse link
G SLC47A1 solute carrier family 47 member 1 decreases activity EXP tebuconazole results in decreased activity of SLC47A1 protein CTD PMID:36669674 NCBI chr 5:40,643,420...40,679,130
Ensembl chr 5:40,642,784...40,679,946 		JBrowse link
G SLC47A2 solute carrier family 47 member 2 decreases activity EXP tebuconazole results in decreased activity of SLC47A2 protein CTD PMID:36669674 NCBI chr 5:40,491,306...40,515,430
Ensembl chr 5:40,491,933...40,540,136 		JBrowse link
Temocaprilat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 protein affects the transport of temocaprilat CTD PMID:15507541 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740 		JBrowse link
tolfenamic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS2 prostaglandin-endoperoxide synthase 2 decreases expression EXP tolfenamic acid results in decreased expression of PTGS2 mRNA CTD PMID:15198222 NCBI chr 7:19,668,079...19,674,903
Ensembl chr 7:19,668,082...19,674,903 		JBrowse link
triazoles term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NR1I3 nuclear receptor subfamily 1 group I member 3 increases activity EXP Triazoles results in increased activity of NR1I3 protein alternative form CTD PMID:21778469 NCBI chr38:21,252,874...21,257,951
Ensembl chr38:21,253,089...21,258,827 		JBrowse link
triticonazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A5 solute carrier family 22 member 5 decreases activity EXP triticonazole results in decreased activity of SLC22A5 protein CTD PMID:36669674 NCBI chr11:20,659,023...20,686,359
Ensembl chr11:20,598,888...20,683,087 		JBrowse link
G SLC47A1 solute carrier family 47 member 1 decreases activity EXP triticonazole results in decreased activity of SLC47A1 protein CTD PMID:36669674 NCBI chr 5:40,643,420...40,679,130
Ensembl chr 5:40,642,784...40,679,946 		JBrowse link
troglitazone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RPS6KB1 ribosomal protein S6 kinase B1 multiple interactions EXP Troglitazone results in decreased activity of and results in decreased phosphorylation of RPS6KB1 protein CTD PMID:16825603 NCBI chr 9:34,387,084...34,590,603
Ensembl chr 9:34,387,091...34,425,292 		JBrowse link
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX-agent results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702 		JBrowse link
G SCT secretin multiple interactions EXP Atropine inhibits the reaction [SCT protein results in increased abundance of Bicarbonates] CTD PMID:3562434
tunicamycin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP Tunicamycin results in increased expression of HSP90B1 protein CTD PMID:17416481 NCBI chr15:42,456,793...42,474,122
Ensembl chr15:42,456,764...42,579,311 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Tunicamycin results in increased expression of HSPA5 protein CTD PMID:17416481 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257 		JBrowse link
uniconazole term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC22A5 solute carrier family 22 member 5 decreases activity EXP uniconazole results in decreased activity of SLC22A5 protein CTD PMID:36669674 NCBI chr11:20,659,023...20,686,359
Ensembl chr11:20,598,888...20,683,087 		JBrowse link
G SLC47A1 solute carrier family 47 member 1 decreases activity EXP uniconazole results in decreased activity of SLC47A1 protein CTD PMID:36669674 NCBI chr 5:40,643,420...40,679,130
Ensembl chr 5:40,642,784...40,679,946 		JBrowse link
urea term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 increases expression EXP Urea results in increased expression of CLDN4 protein CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145 		JBrowse link
G SOD2 superoxide dismutase 2 increases expression EXP Urea results in increased expression of SOD2 protein CTD PMID:22718889 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706 		JBrowse link
UTP term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G P2RY2 purinergic receptor P2Y2 increases activity
multiple interactions		 EXP Uridine Triphosphate results in increased activity of P2RY2 protein
[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid; [Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Arachidonic Acid]; pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid inhibits the reaction [[Uridine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Cyclic AMP]		 CTD PMID:10604969 NCBI chr21:24,987,568...25,009,754
Ensembl chr21:24,992,848...24,996,059 		JBrowse link
vasopressin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin multiple interactions EXP INS protein promotes the reaction [Sodium results in increased abundance of Vasopressins] CTD PMID:1324617 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122 		JBrowse link
verapamil term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP [Verapamil results in decreased activity of ABCB1 protein] which affects the transport of Digoxin CTD PMID:20510202 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
vincristine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 affects response to substance
multiple interactions
increases export		 EXP ABCB1 protein affects the susceptibility to Vincristine
valspodar inhibits the reaction [ABCB1 protein affects the susceptibility to Vincristine]
ABCB1 protein results in increased export of Vincristine		 CTD PMID:24975508 PMID:28093773 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727 		JBrowse link
G ABCC1 ATP binding cassette subfamily C member 1 decreases response to substance EXP ABCC1 protein results in decreased susceptibility to Vincristine CTD PMID:12516967 NCBI chr 6:27,855,702...27,950,140
Ensembl chr 6:27,855,702...27,989,331 		JBrowse link
vorinostat term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASQ1 calsequestrin 1 decreases expression EXP Vorinostat results in decreased expression of CASQ1 mRNA CTD PMID:27255383 NCBI chr38:22,012,060...22,020,430
Ensembl chr38:22,011,060...22,020,383 		JBrowse link
G HSP70 heat shock protein 70 decreases expression EXP Vorinostat results in decreased expression of HSP70 mRNA CTD PMID:27255383 NCBI chr12:1,285,282...1,287,670 JBrowse link
G TNNI3K TNNI3 interacting kinase decreases expression EXP Vorinostat results in decreased expression of TNNI3K mRNA CTD PMID:27255383 NCBI chr 6:71,825,853...72,107,832
Ensembl chr 6:71,815,734...72,119,476 		JBrowse link
VX nerve agent term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase decreases activity
multiple interactions		 EXP VX-agent results in decreased activity of ACHE protein
[Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX-agent results in decreased activity of ACHE protein]		 CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702 		JBrowse link
G BCHE butyrylcholinesterase decreases activity EXP VX-agent results in decreased activity of BCHE protein CTD PMID:16915560 NCBI chr34:30,912,632...30,977,624
Ensembl chr34:30,912,632...30,977,583 		JBrowse link
WIN 55212-2 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CNR2 cannabinoid receptor 2 affects binding EXP (3R)-((2,3-dihydro-5-methyl-3-((4-morpholinyl)methyl)pyrrolo-(1,2,3-de)-1,4-benzoxazin-6-yl)(1-naphthalenyl))methanone binds to CNR2 protein CTD PMID:21871882 NCBI chr 2:75,640,636...75,662,000
Ensembl chr 2:75,658,999...75,660,126 		JBrowse link
YM-254890 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HEXB hexosaminidase subunit beta multiple interactions EXP YM-254890 inhibits the reaction [mastoparan results in increased secretion of HEXB protein] CTD PMID:21671308 NCBI chr 2:57,221,809...57,248,432
Ensembl chr 2:57,222,186...57,248,417 		JBrowse link
yohimbine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions EXP Yohimbine inhibits the reaction [[Clonidine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; Yohimbine inhibits the reaction [Clonidine results in increased activity of PIK3CG protein] CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141 		JBrowse link
G PRKCZ protein kinase C zeta multiple interactions EXP Yohimbine inhibits the reaction [Clonidine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664 		JBrowse link
zileuton term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALOX5 arachidonate 5-lipoxygenase decreases activity EXP zileuton results in decreased activity of ALOX5 protein CTD PMID:1618819 NCBI chr28:2,170,920...2,218,765
Ensembl chr28:2,170,920...2,219,609 		JBrowse link
Term paths to the root
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  CHEBI ontology 1271
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            pnictogen 421
              antimony atom + 0
              arsenic atom + 9
              bismuth atom + 0
              moscovium atom + 0
              nitrogen atom + 419
              phosphorus atom + 9
              pnictogen molecular entity + 421
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  CHEBI ontology 1271
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      composite particle 1271
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              atomic nucleus 1271
                atom 1271
                  main group element atom 1264
                    p-block element atom 1264
                      pnictogen 421
                        antimony atom + 0
                        arsenic atom + 9
                        bismuth atom + 0
                        moscovium atom + 0
                        nitrogen atom + 419
                        phosphorus atom + 9
                        pnictogen molecular entity + 421
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