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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:Calpeptin
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Accession:CHEBI:3330 term browser browse the term
Definition:An amino acid amide that has formula C20H30N2O4.
Synonyms:related_synonym: Formula=C20H30N2O4;   InChI=1S/C20H30N2O4/c1-4-5-11-17(13-23)21-19(24)18(12-15(2)3)22-20(25)26-14-16-9-7-6-8-10-16/h6-10,13,15,17-18H,4-5,11-12,14H2,1-3H3,(H,21,24)(H,22,25)/t17-,18-/m0/s1;   InChIKey=PGGUOGKHUUUWAF-ROUUACIJSA-N;   N-Cbz-leu-nleu-al;   SMILES=CCCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1)C=O
 xref: CAS:117591-20-5;   KEGG:C11256;   LINCS:LSM-2570
 xref_mesh: MESH:C071482


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Calpeptin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions
decreases cleavage
ISO calpeptin inhibits the reaction [arsenic trioxide results in increased cleavage of BAX protein]
calpeptin results in decreased cleavage of BAX protein
CTD PMID:15131059 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Capn1 calpain 1 multiple interactions ISO
EXP
calpeptin inhibits the reaction [CAPN1 protein results in increased degradation of MFN2 protein]; calpeptin inhibits the reaction [Paraquat results in increased activity of CAPN1 protein]
calpeptin inhibits the reaction [Acrylamide results in increased expression of CAPN1 protein]
CTD PMID:24509835 PMID:25416777 PMID:30096436 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
JBrowse link
G Capn2 calpain 2 multiple interactions EXP calpeptin inhibits the reaction [Acrylamide results in increased expression of CAPN2 protein] CTD PMID:29524570 PMID:30096436 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Casp3 caspase 3 multiple interactions ISO
EXP
calpeptin inhibits the reaction [[lactacystin results in increased activity of CASP3 protein] which results in increased cleavage of SPTAN1 protein]; calpeptin inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]
calpeptin inhibits the reaction [Paraquat results in increased cleavage of CASP3 protein]
CTD PMID:21683092 PMID:25947082 PMID:29111403 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 multiple interactions ISO calpeptin inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein] CTD PMID:29111403 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Ccne2 cyclin E2 decreases expression ISO calpeptin results in decreased expression of CCNE2 protein CTD PMID:22432027 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cdk5 cyclin-dependent kinase 5 multiple interactions EXP calpeptin inhibits the reaction [Acrylamide results in increased expression of CDK5 protein] CTD PMID:30096436 NCBI chr 4:7,282,945...7,287,427
Ensembl chr 4:7,282,948...7,288,383
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions ISO calpeptin inhibits the reaction [arsenite metabolite results in increased cleavage of CDK5R1 protein]; calpeptin inhibits the reaction [Calcium results in increased cleavage of CDK5R1 protein] CTD PMID:18242949 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO calpeptin results in increased expression of CDKN1A protein CTD PMID:22432027 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression ISO calpeptin results in decreased expression of CDKN1B protein modified form CTD PMID:22432027 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO calpeptin inhibits the reaction [dehydroeburicoic acid affects the localization of MAP1LC3B protein]; calpeptin inhibits the reaction [dehydroeburicoic acid promotes the reaction [MAP1LC3B protein binds to phosphatidylethanolamine]] CTD PMID:19848398 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP calpeptin inhibits the reaction [Acrylamide results in decreased expression of MAP2 protein]; calpeptin inhibits the reaction [Acrylamide results in increased expression of MAP2 protein] CTD PMID:29524570 PMID:30096436 NCBI chr 9:73,204,753...73,462,965
Ensembl chr 9:73,319,710...73,462,972
JBrowse link
G Mapt microtubule-associated protein tau multiple interactions EXP calpeptin inhibits the reaction [Acrylamide results in increased expression of MAPT protein] CTD PMID:30096436 NCBI chr10:92,289,002...92,386,517
Ensembl chr10:92,288,910...92,386,517
JBrowse link
G Mfn2 mitofusin 2 multiple interactions ISO
EXP
calpeptin inhibits the reaction [CAPN1 protein results in increased degradation of MFN2 protein]
calpeptin inhibits the reaction [Excitatory Amino Acid Agonists results in decreased expression of MFN2 protein]
CTD PMID:25416777 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Nefl neurofilament light chain multiple interactions EXP calpeptin inhibits the reaction [Calcium results in increased degradation of NEFL protein] CTD PMID:11071371 NCBI chr15:44,799,378...44,803,251
Ensembl chr15:44,799,334...44,804,574
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions EXP
ISO
calpeptin inhibits the reaction [Paraquat results in increased cleavage of PARP1 protein]
calpeptin inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]
CTD PMID:25947082 PMID:29111403 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ptpn11 protein tyrosine phosphatase, non-receptor type 11 decreases phosphorylation
multiple interactions
ISO calpeptin results in decreased phosphorylation of PTPN11 protein
LM11A-31 inhibits the reaction [calpeptin results in decreased phosphorylation of PTPN11 protein]
CTD PMID:25277379 NCBI chr12:40,895,515...40,955,999
Ensembl chr12:40,895,515...40,955,999
JBrowse link
G Rhoa ras homolog family member A increases activity
multiple interactions
ISO calpeptin results in increased activity of RHOA protein
LM11A-31 inhibits the reaction [calpeptin results in increased activity of RHOA protein]
CTD PMID:25277379 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Snca synuclein alpha multiple interactions ISO calpeptin inhibits the reaction [Paraquat results in increased expression of SNCA protein alternative form] CTD PMID:24509835 NCBI chr 4:90,782,412...90,883,236
Ensembl chr 4:90,782,374...90,882,285
JBrowse link
G Sptan1 spectrin, alpha, non-erythrocytic 1 multiple interactions ISO calpeptin inhibits the reaction [dehydroeburicoic acid results in increased degradation of SPTAN1 protein]
calpeptin inhibits the reaction [[lactacystin results in increased activity of CASP3 protein] which results in increased cleavage of SPTAN1 protein]; calpeptin inhibits the reaction [lactacystin results in increased cleavage of SPTAN1 protein]
CTD PMID:19848398 PMID:21683092 NCBI chr 3:8,534,437...8,599,259
Ensembl chr 3:8,534,440...8,599,260
JBrowse link
G Tp73 tumor protein p73 multiple interactions ISO calpeptin inhibits the reaction [Cisplatin results in decreased expression of TP73 protein modified form] CTD PMID:21516125 NCBI chr 5:171,355,876...171,415,354
Ensembl chr 5:171,355,876...171,415,354
JBrowse link
G Tubb5 tubulin, beta 5 class I multiple interactions EXP calpeptin inhibits the reaction [Acrylamide results in increased expression of TUBB protein]; calpeptin inhibits the reaction [Acrylamide results in increased expression of TUBB5 protein] CTD PMID:29524570 PMID:30096436 NCBI chr20:3,422,448...3,426,420
Ensembl chr20:3,422,461...3,426,371
JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases degradation ISO calpeptin results in decreased degradation of XIAP protein CTD PMID:16223472 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19770
    chemical entity 19770
      atom 19768
        nonmetal atom 19651
          nitrogen atom 18582
            nitrogen molecular entity 18582
              organonitrogen compound 18370
                carboxamide 17208
                  amino acid amide 890
                    Calpeptin 23
Path 2
Term Annotations click to browse term
  CHEBI ontology 19770
    subatomic particle 19768
      composite particle 19768
        hadron 19768
          baryon 19768
            nucleon 19768
              atomic nucleus 19768
                atom 19768
                  main group element atom 19662
                    p-block element atom 19662
                      carbon group element atom 19580
                        carbon atom 19571
                          organic molecular entity 19571
                            organic group 18602
                              organic divalent group 18593
                                organodiyl group 18593
                                  carbonyl group 18506
                                    carbonyl compound 18506
                                      carboxylic acid 18158
                                        carboacyl group 17412
                                          univalent carboacyl group 17412
                                            carbamoyl group 17208
                                              carboxamide 17208
                                                amino acid amide 890
                                                  Calpeptin 23
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