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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:thiamine(1+) chloride
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Accession:CHEBI:33283 term browser browse the term
Definition:A thiamine that has formula C12H17ClN4OS.
Synonyms:exact_synonym: 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride
 related_synonym: 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium chloride;   Formula=C12H17ClN4OS;   InChI=1S/C12H17N4OS.ClH/c1-8-11(3-4-17)18-7-16(8)6-10-5-14-9(2)15-12(10)13;/h5,7,17H,3-4,6H2,1-2H3,(H2,13,14,15);1H/q+1;/p-1;   InChIKey=MYVIATVLJGTBFV-UHFFFAOYSA-M;   SMILES=[Cl-].Cc1ncc(C[n+]2csc(CCO)c2C)c(N)n1;   Thiamin;   thiamine;   thiamine chloride;   thiamine monochloride;   thiaminum;   tiamina;   vitamin B1
 xref: Beilstein:3581326;   CAS:59-43-8;   Chemspider:5819;   DrugBank:DBSALT002650;   Gmelin:318226;   KEGG:D08580
 xref_mesh: MESH:D013831
 xref: PMID:23914634;   PMID:25552500;   Wikipedia:Thiamine


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thiamine(1+) chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akt1 AKT serine/threonine kinase 1 multiple interactions EXP
ISO
Thiamine inhibits the reaction [citreoviridin results in decreased phosphorylation of AKT1 protein] CTD PMID:31419397 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aqp7 aquaporin 7 increases expression
multiple interactions
EXP
ISO
Thiamine results in increased expression of AQP7 mRNA
Thiamine inhibits the reaction [citreoviridin results in decreased expression of AQP7 mRNA]
CTD PMID:31419397 NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP
ISO
Thiamine inhibits the reaction [citreoviridin results in increased expression of BAX protein] CTD PMID:31419397 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
Thiamine inhibits the reaction [citreoviridin results in decreased expression of BCL2 protein] CTD PMID:31419397 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions EXP Thiamine inhibits the reaction [Pentylenetetrazole results in increased expression of CASP3 protein] CTD PMID:33771525 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ckb creatine kinase B multiple interactions ISO
EXP
Thiamine inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:31419397 NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP
ISO
Thiamine inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]] CTD PMID:31419397 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased activity of CYP2E1 protein]; [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP2E1 mRNA] CTD PMID:27919644 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions EXP [Methionine co-treated with Thiamine co-treated with Niacinamide co-treated with alpha-Tocopherol co-treated with Zinc] inhibits the reaction [[Isoniazid co-treated with Rifampin co-treated with Ethambutol co-treated with Pyrazinamide] results in increased expression of CYP3A2 mRNA] CTD PMID:27919644 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Fabp4 fatty acid binding protein 4 multiple interactions
increases expression
EXP
ISO
Thiamine inhibits the reaction [citreoviridin results in decreased expression of FABP4 mRNA]
Thiamine results in increased expression of FABP4 mRNA
CTD PMID:31419397 NCBI chr 2:91,580,858...91,585,578
Ensembl chr 2:91,580,885...91,585,578
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO
EXP
Thiamine inhibits the reaction [citreoviridin results in increased expression of MAP1LC3B protein modified form] CTD PMID:31419397 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions ISO NFE2L2 protein affects the reaction [Thiamine results in increased expression of NQO1 mRNA] CTD PMID:29860433 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
ISO NFE2L2 protein affects the reaction [Thiamine results in increased expression of NQO1 mRNA] CTD PMID:29860433 NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases activity
multiple interactions
EXP Thiamine results in increased activity of PPARG protein
Thiamine inhibits the reaction [citreoviridin results in decreased activity of PPARG protein]
CTD PMID:31419397 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 increases expression EXP [Thiamine deficiency results in increased expression of PTGS2 mRNA] which results in increased expression of Dinoprostone; Thiamine deficiency results in increased expression of PTGS2 mRNA CTD PMID:18481165 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Slc19a2 solute carrier family 19 member 2 increases uptake
multiple interactions
increases expression
ISO SLC19A2 protein results in increased uptake of Thiamine
[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SLC19A2 protein] which results in decreased uptake of Thiamine
Thiamine deficiency results in increased expression of SLC19A2 mRNA; Thiamine deficiency results in increased expression of SLC19A2 protein
CTD PMID:16705148 PMID:24244374 NCBI chr13:76,601,975...76,616,175
Ensembl chr13:76,601,900...76,616,172
JBrowse link
G Slc19a3 solute carrier family 19 member 3 increases expression
increases uptake
multiple interactions
ISO Thiamine deficiency results in increased expression of SLC19A3 mRNA; Thiamine deficiency results in increased expression of SLC19A3 protein
SLC19A3 protein results in increased uptake of Thiamine
[4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in decreased expression of SLC19A3 protein] which results in decreased uptake of Thiamine
Amprolium inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]; Chloroquine inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]; Famotidine inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]; Metformin inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]; Phenformin inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]; Verapamil inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]
CTD PMID:16705148 PMID:24244374 PMID:26528626 NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions EXP
ISO
Thiamine inhibits the reaction [citreoviridin results in decreased expression of SQSTM1 protein] CTD PMID:31419397 NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Tnnt2 troponin T2, cardiac type multiple interactions EXP
ISO
Thiamine inhibits the reaction [citreoviridin results in increased secretion of TNNT2 protein] CTD PMID:31419397 NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19821
    chemical entity 19821
      molecular entity 19819
        ion 16059
          organic ion 9147
            organic cation 8091
              1,3-thiazolium cation 31
                vitamin B1 31
                  thiamine(1+) chloride 19
Path 2
Term Annotations click to browse term
  CHEBI ontology 19821
    subatomic particle 19819
      composite particle 19819
        hadron 19819
          baryon 19819
            nucleon 19819
              atomic nucleus 19819
                atom 19819
                  main group element atom 19716
                    p-block element atom 19716
                      carbon group element atom 19640
                        carbon atom 19630
                          organic molecular entity 19630
                            organic molecule 19569
                              organic cyclic compound 19360
                                organic heterocyclic compound 18591
                                  heteroarene 16530
                                    monocyclic heteroarene 13437
                                      azole 12628
                                        thiazoles 1712
                                          1,3-thiazoles 1157
                                            1,3-thiazolium cation 31
                                              vitamin B1 31
                                                thiamine(1+) 31
                                                  thiamine(1+) chloride 19
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