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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:molecular messenger
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Accession:CHEBI:33280 term browser browse the term
Synonyms:related_synonym: chemical messenger


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(R)-adrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NPPA natriuretic peptide A affects abundance EXP NPPA protein affects the abundance of Epinephrine CTD PMID:2951327 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
JBrowse link
(R)-noradrenaline term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADRB1 adrenoceptor beta 1 increases activity EXP Norepinephrine results in increased activity of ADRB1 protein CTD PMID:10344530 NCBI chr28:24,908,224...24,909,684
Ensembl chr28:24,908,224...24,909,684
JBrowse link
G ADRB2 adrenoceptor beta 2 multiple interactions EXP [Propranolol binds to and results in decreased activity of ADRB2 protein] which results in decreased secretion of Norepinephrine CTD PMID:2884805 NCBI chr 4:60,048,502...60,050,447
Ensembl chr 4:59,941,517...60,050,298
JBrowse link
G NPPA natriuretic peptide A increases expression EXP Norepinephrine results in increased expression of NPPA protein CTD PMID:8952593 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
JBrowse link
G PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma multiple interactions
increases activity
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased activity of PIK3CG protein]; [Norepinephrine results in increased activity of PIK3CG protein] which results in increased chemical synthesis of phosphatidylinositol 3-phosphate CTD PMID:15958164 NCBI chr18:13,576,966...13,611,748
Ensembl chr18:13,570,999...13,611,141
JBrowse link
G POMC proopiomelanocortin increases response to substance EXP POMC protein results in increased susceptibility to Norepinephrine CTD PMID:6279499 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
JBrowse link
G PRKCZ protein kinase C zeta multiple interactions
increases phosphorylation
EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of PRKCZ protein] CTD PMID:15958164 NCBI chr 5:57,012,020...57,113,346
Ensembl chr 5:57,012,070...57,112,664
JBrowse link
G REN renin increases activity EXP Norepinephrine results in increased activity of REN protein CTD PMID:8952593 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
1,2-dihexadecanoyl-sn-glycero-3-phosphocholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PLCG1 phospholipase C gamma 1 decreases activity
multiple interactions
EXP 1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein
dipalmitoylphosphatidic acid inhibits the reaction [1,2-Dipalmitoylphosphatidylcholine results in decreased activity of PLCG1 protein]
CTD PMID:2001791 NCBI chr24:29,198,536...29,213,899
Ensembl chr24:29,198,556...29,214,714
JBrowse link
1,4-dithiothreitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Dithiothreitol metabolite results in increased expression of HSPA5 protein CTD PMID:17416481 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257
JBrowse link
17beta-estradiol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCC2 ATP binding cassette subfamily C member 2 affects transport EXP ABCC2 protein affects the transport of Estradiol CTD PMID:15507541 NCBI chr28:12,670,885...12,740,124
Ensembl chr28:12,670,885...12,740,740
JBrowse link
G ESR1 estrogen receptor 1 affects expression EXP Estradiol affects the expression of ESR1 protein CTD PMID:16483645 NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544
JBrowse link
17beta-estradiol 17-glucosiduronic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B3 solute carrier organic anion transporter family member 1B3 increases transport EXP SLCO1B3 protein results in increased transport of estradiol-17 beta-glucuronide CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989
JBrowse link
17beta-hydroxy-5alpha-androstan-3-one term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SOD2 superoxide dismutase 2 multiple interactions EXP Dihydrotestosterone promotes the reaction [Hydrogen Peroxide results in decreased activity of SOD2 protein] CTD PMID:16682413 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
JBrowse link
acetylcholine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KCNJ3 potassium inwardly rectifying channel subfamily J member 3 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr36:1,354,686...1,496,397
Ensembl chr36:1,354,678...1,493,766
JBrowse link
G KCNJ6 potassium inwardly rectifying channel subfamily J member 6 multiple interactions EXP Acetylcholine promotes the reaction [[KCNJ3 protein co-treated with KCNJ6 protein] results in increased transport of Potassium] CTD PMID:10666054 NCBI chr31:32,752,585...33,010,999
Ensembl chr31:32,755,899...32,934,478
JBrowse link
G MAPK14 mitogen-activated protein kinase 14 multiple interactions EXP Acetylcholine results in increased phosphorylation of and results in increased activity of MAPK14 protein CTD PMID:9688607 NCBI chr12:5,145,647...5,221,558
Ensembl chr12:5,146,037...5,220,603
JBrowse link
acetylsalicylic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Aspirin results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
aldosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen increases abundance EXP AGT results in increased abundance of Aldosterone CTD PMID:2831029 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
JBrowse link
G POMC proopiomelanocortin increases abundance EXP POMC protein results in increased abundance of Aldosterone CTD PMID:2831029 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
JBrowse link
all-trans-retinoic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CASP3 caspase 3 increases activity EXP Tretinoin results in increased activity of CASP3 protein CTD PMID:16953078 NCBI chr16:45,920,074...45,940,507
Ensembl chr16:45,920,071...45,940,505
JBrowse link
G CLDN1 claudin 1 multiple interactions
increases expression
EXP CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN1 mRNA]
Tretinoin results in increased expression of CLDN1 mRNA; Tretinoin results in increased expression of CLDN1 protein
CTD PMID:17035595 NCBI chr34:22,303,058...22,319,101
Ensembl chr34:22,303,850...22,319,033
JBrowse link
G CLDN4 claudin 4 increases expression
multiple interactions
EXP Tretinoin results in increased expression of CLDN4 mRNA; Tretinoin results in increased expression of CLDN4 protein
CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN4 mRNA]
CTD PMID:17035595 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
JBrowse link
G CYP26A1 cytochrome P450 family 26 subfamily A member 1 increases degradation
multiple interactions
EXP CYP26A1 protein results in increased degradation of Tretinoin
CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN1 mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of CLDN4 mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of OCLN mRNA]; CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of TJP1 mRNA]
CTD PMID:17035595 NCBI chr28:7,423,955...7,432,359
Ensembl chr28:7,428,772...7,432,370
JBrowse link
G NOS3 nitric oxide synthase 3 increases expression EXP Tretinoin results in increased expression of NOS3 mRNA; Tretinoin results in increased expression of NOS3 protein CTD PMID:17267746 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
JBrowse link
G OCLN occludin multiple interactions
increases expression
EXP CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of OCLN mRNA]
Tretinoin results in increased expression of OCLN mRNA; Tretinoin results in increased expression of OCLN protein
CTD PMID:17035595 NCBI chr 2:54,500,299...54,545,430
Ensembl chr 2:54,500,299...54,545,430
JBrowse link
G TJP1 tight junction protein 1 increases expression
multiple interactions
EXP Tretinoin results in increased expression of TJP1 mRNA; Tretinoin results in increased expression of TJP1 protein
CYP26A1 protein inhibits the reaction [Tretinoin results in increased expression of TJP1 mRNA]
CTD PMID:17035595 NCBI chr 3:38,997,122...39,076,617
Ensembl chr 3:38,997,076...39,241,574
JBrowse link
atropine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
JBrowse link
calcitriol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BCL2 BCL2 apoptosis regulator affects expression EXP Calcitriol affects the expression of BCL2 protein CTD PMID:16080513 NCBI chr 1:13,733,849...13,900,653
Ensembl chr 1:13,731,406...13,900,658
JBrowse link
corticotropin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin increases abundance EXP INS protein results in increased abundance of Adrenocorticotropic Hormone CTD PMID:1646414 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
JBrowse link
cortisol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CRH corticotropin releasing hormone increases abundance EXP CRH protein results in increased abundance of Hydrocortisone CTD PMID:2831029 NCBI chr29:15,831,944...15,840,560
Ensembl chr29:15,831,944...15,834,384
JBrowse link
G INS insulin affects abundance
multiple interactions
EXP INS protein affects the abundance of Hydrocortisone
Sodium affects the reaction [INS protein affects the abundance of Hydrocortisone]
CTD PMID:1324617 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
JBrowse link
G POMC proopiomelanocortin increases abundance EXP POMC protein results in increased abundance of Hydrocortisone CTD PMID:2831029 NCBI chr17:19,431,396...19,438,247
Ensembl chr17:19,431,585...19,434,440
JBrowse link
dexamethasone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AVP arginine vasopressin decreases expression EXP Dexamethasone results in decreased expression of AVP protein CTD PMID:1934541 NCBI chr24:18,183,057...18,184,827
Ensembl chr24:18,183,057...18,184,883
JBrowse link
G HSD11B1 hydroxysteroid 11-beta dehydrogenase 1 increases expression EXP Dexamethasone results in increased expression of HSD11B1 mRNA CTD PMID:21798686 NCBI chr 7:8,344,380...8,409,901
Ensembl chr 7:8,344,447...8,409,897
JBrowse link
G NPPA natriuretic peptide A increases expression EXP Dexamethasone results in increased expression of NPPA protein CTD PMID:1934541 NCBI chr 2:84,406,317...84,408,115
Ensembl chr 2:84,396,073...84,408,385
JBrowse link
diclofenac term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CYP2C18 cytochrome P450 2C21 increases hydroxylation EXP CYP2C19 protein results in increased hydroxylation of Diclofenac CTD PMID:15677349 NCBI chr28:8,727,010...8,750,427
Ensembl chr28:8,727,019...8,750,587
JBrowse link
G CYP2C41 cytochrome P450 2C41 affects metabolic processing EXP CYP2C9 protein affects the metabolism of Diclofenac CTD PMID:15801540
G PTGS1 prostaglandin-endoperoxide synthase 1 decreases activity EXP Diclofenac results in decreased activity of PTGS1 protein alternative form CTD PMID:12242329 NCBI chr 9:60,195,118...60,216,847
Ensembl chr 9:60,195,124...60,216,819
JBrowse link
estrone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ALPI alkaline phosphatase, intestinal increases chemical synthesis EXP ALPI protein results in increased chemical synthesis of Estrone CTD PMID:1495895 NCBI chr25:44,107,418...44,110,947 JBrowse link
estrone 3-sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLCO1B3 solute carrier organic anion transporter family member 1B3 increases transport EXP SLCO1B3 protein results in increased transport of estrone sulfate CTD PMID:20079461 NCBI chr27:26,411,008...26,496,174
Ensembl chr27:26,411,010...26,470,989
JBrowse link
genistein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CFTR CF transmembrane conductance regulator decreases activity EXP Genistein results in decreased activity of CFTR protein CTD PMID:15496164 NCBI chr14:56,290,417...56,452,919
Ensembl chr14:56,290,275...56,453,977
JBrowse link
G DHRS4 dehydrogenase/reductase 4 decreases activity EXP Genistein results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
glutathione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CLDN4 claudin 4 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased expression of CLDN4 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased expression of CLDN4 protein] CTD PMID:23816505 NCBI chr 6:6,492,706...6,506,750
Ensembl chr 6:6,493,513...6,494,145
JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK1 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK1 protein] CTD PMID:23816505 NCBI chr26:31,013,607...31,132,998
Ensembl chr26:31,013,607...31,132,998
JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK3 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK3 protein] CTD PMID:23816505 NCBI chr 6:18,109,184...18,115,728
Ensembl chr 6:18,109,222...18,114,425
JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK8 protein] CTD PMID:23816505 NCBI chr28:323,361...410,367
Ensembl chr28:368,513...406,401
JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions EXP Glutathione inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK9 protein]; Glutathione inhibits the reaction [Sodium Chloride results in increased phosphorylation of MAPK9 protein] CTD PMID:23816505 NCBI chr11:1,443,528...1,480,501
Ensembl chr11:1,443,547...1,478,119
JBrowse link
icariin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 increases activity EXP icariin results in increased activity of NOS3 protein CTD PMID:17438405 NCBI chr16:15,054,196...15,072,454
Ensembl chr16:15,011,344...15,072,277
JBrowse link
L-1,4-dithiothreitol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Dithiothreitol metabolite results in increased expression of HSPA5 protein CTD PMID:17416481 NCBI chr 9:57,850,870...57,855,607
Ensembl chr 9:57,850,922...57,855,257
JBrowse link
nitric oxide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G KNG1 kininogen 1 increases activity EXP Nitric Oxide deficiency results in increased activity of KNG1 protein modified form CTD PMID:10805402 NCBI chr34:19,288,629...19,318,096
Ensembl chr34:19,287,109...19,318,081
JBrowse link
G WT1 WT1 transcription factor multiple interactions EXP [Nitroprusside results in increased abundance of Nitric Oxide] which results in increased expression of WT1 mRNA CTD PMID:21443142 NCBI chr18:35,099,660...35,148,767
Ensembl chr18:35,103,934...35,148,000
JBrowse link
ouabain term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G REN renin decreases secretion
multiple interactions
EXP Ouabain results in decreased secretion of REN protein
Vanadates inhibits the reaction [Ouabain results in decreased secretion of REN protein]
CTD PMID:6093556 NCBI chr38:744,540...766,998
Ensembl chr38:744,614...755,012
JBrowse link
progesterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ESR1 estrogen receptor 1 affects expression EXP Progesterone affects the expression of ESR1 protein CTD PMID:16483645 NCBI chr 1:42,081,952...42,368,544
Ensembl chr 1:42,081,969...42,368,544
JBrowse link
G PGR progesterone receptor affects binding EXP Progesterone binds to PGR protein CTD PMID:16054490 NCBI chr21:447,197...552,511
Ensembl chr21:447,319...552,511
JBrowse link
quercetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions EXP Quercetin inhibits the reaction [ABCB1 protein results in increased secretion of Ritonavir] CTD PMID:15266218 NCBI chr14:13,644,891...13,852,829
Ensembl chr14:13,542,647...13,742,727
JBrowse link
G DHRS4 dehydrogenase/reductase 4 decreases activity EXP Quercetin results in decreased activity of DHRS4 protein CTD PMID:17827741 NCBI chr 8:4,046,532...4,058,498
Ensembl chr 8:4,046,544...4,084,744
JBrowse link
G HSP70 heat shock protein 70 decreases expression EXP Quercetin results in decreased expression of HSP70 protein CTD PMID:17009600 NCBI chr12:1,285,282...1,287,670 JBrowse link
salicylamide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AHR aryl hydrocarbon receptor multiple interactions EXP [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to prochloraz; [salicylamide binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Tetrachlorodibenzodioxin CTD PMID:24389113 NCBI chr14:31,743,704...31,793,484
Ensembl chr14:31,686,170...31,791,444
JBrowse link
serotonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AGT angiotensinogen increases response to substance
multiple interactions
EXP AGT protein modified form results in increased susceptibility to Serotonin
Deferoxamine inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin]; Reactive Oxygen Species inhibits the reaction [AGT protein modified form results in increased susceptibility to Serotonin]
CTD PMID:8021468 NCBI chr 4:8,681,192...8,694,059
Ensembl chr 4:8,683,798...8,693,880
JBrowse link
G EDN1 endothelin 1 increases activity EXP Serotonin results in increased activity of EDN1 protein CTD PMID:9918753 NCBI chr35:11,808,892...11,815,383
Ensembl chr35:11,808,892...11,815,383
JBrowse link
succimer term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GSR glutathione-disulfide reductase multiple interactions EXP [monoisoamyl-2,3-dimercaptosuccinate co-treated with Succimer] inhibits the reaction [sodium arsenite results in decreased activity of GSR protein] CTD PMID:18163546 NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752
JBrowse link
testosterone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G B9D2 B9 domain containing 2 increases expression EXP Testosterone results in increased expression of TGFB1 mRNA CTD PMID:17157324 NCBI chr 1:112,621,832...112,627,726
Ensembl chr 1:112,621,633...112,643,885
JBrowse link
G KCND3 potassium voltage-gated channel subfamily D member 3 increases expression EXP Testosterone results in increased expression of KCND3 protein CTD PMID:17054656 NCBI chr17:63,470,829...63,668,354
Ensembl chr17:63,470,415...63,668,035
JBrowse link
G KCNJ2 potassium inwardly rectifying channel subfamily J member 2 increases expression EXP Testosterone results in increased expression of KCNJ2 protein CTD PMID:17054656 NCBI chr 9:16,468,938...16,475,722
Ensembl chr 9:16,468,938...16,475,722
JBrowse link
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACHE acetylcholinesterase multiple interactions EXP [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Sarin results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [Soman results in decreased activity of ACHE protein]; [Obidoxime Chloride co-treated with Atropine] inhibits the reaction [VX results in decreased activity of ACHE protein] CTD PMID:16915560 NCBI chr 6:8,874,747...8,879,926
Ensembl chr 6:8,873,584...8,879,702
JBrowse link
vasopressin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G INS insulin multiple interactions EXP INS protein promotes the reaction [Sodium results in increased abundance of Vasopressins] CTD PMID:1324617 NCBI chr18:46,324,047...46,324,933
Ensembl chr18:46,324,041...46,325,122
JBrowse link
zearalenone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCG2 ATP binding cassette subfamily G member 2 increases transport EXP ABCG2 protein results in increased transport of Zearalenone CTD PMID:30576553 NCBI chr32:11,443,778...11,517,674
Ensembl chr32:11,443,780...11,517,674
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 227
    role 227
      biological role 227
        molecular messenger 52
          hormone + 32
          monoamine molecular messenger + 9
          neurotransmitter + 15
          semiochemical + 0
          signalling molecule + 15
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.