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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:alpha-tocotrienol
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Accession:CHEBI:33270 term browser browse the term
Definition:A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 5, 7 and 8 and a farnesyl chain at position 2. It has been found in palm oil derived from Elaeis guineensis.
Synonyms:exact_synonym: (2R)-2,5,7,8-tetramethyl-2-[(3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2H-chromen-6-ol
 related_synonym: Formula=C29H44O2;   InChI=1S/C29H44O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h12,14,16,30H,9-11,13,15,17-19H2,1-8H3/b21-14+,22-16+/t29-/m1/s1;   InChIKey=RZFHLOLGZPDCHJ-XZXLULOTSA-N;   SMILES=CC(C)=CCC\\C(C)=C\\CC\\C(C)=C\\CC[C@]1(C)CCc2c(C)c(O)c(C)c(C)c2O1;   zeta1-tocopherol
 alt_id: CHEBI:35062
 xref: Beilstein:45723;   Beilstein:5484296;   CAS:1721-51-3;   HMDB:HMDB0006327;   KEGG:C14153;   LIPID_MAPS_instance:LMPR02020054
 xref_mesh: MESH:C082032
 xref: MetaCyc:CPD-15836;   PMID:16923160;   PMID:20823491;   PMID:22013739;   PMID:22252050;   PMID:24013375;   Patent:EP2362875;   Patent:US2010105930;   Patent:WO2010051277;   Reaxys:5484296;   Wikipedia:Alpha-Tocotrienol


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alpha-tocotrienol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO tocotrienol, alpha results in increased expression of ABCB1 CTD PMID:15269186 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance
multiple interactions
ISO CYP3A5 gene polymorphism affects the susceptibility to tocotrienol, alpha
tocotrienol, alpha inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; tocotrienol, alpha inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]
CTD PMID:31102695 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO GSTM1 gene polymorphism affects the susceptibility to [Ascorbic Acid co-treated with tocotrienol, alpha] CTD PMID:15668500 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO tocotrienol, alpha inhibits the reaction [NR1I2 protein binds to NCOR1 protein] CTD PMID:15269186 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO tocotrienol, alpha binds to and results in increased activity of NR1I2 protein; tocotrienol, alpha inhibits the reaction [NR1I2 protein binds to NCOR1 protein] CTD PMID:15269186 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO tocotrienol, alpha results in increased expression of UGT1A1 CTD PMID:15269186 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19785
    role 19732
      chemical role 19248
        antioxidant 14209
          vitamin E 1725
            alpha-tocotrienol 6
Path 2
Term Annotations click to browse term
  CHEBI ontology 19785
    subatomic particle 19782
      composite particle 19782
        hadron 19782
          baryon 19782
            nucleon 19782
              atomic nucleus 19782
                atom 19782
                  main group element atom 19670
                    p-block element atom 19670
                      carbon group element atom 19572
                        carbon atom 19561
                          organic molecular entity 19561
                            organic molecule 19486
                              organic cyclic compound 19282
                                organic heterocyclic compound 18407
                                  oxacycle 17181
                                    benzopyran 10132
                                      1-benzopyran 9848
                                        chromanes 3918
                                          chromanol 1725
                                            chroman-6-ol 1725
                                              tocol 250
                                                tocotrienol 42
                                                  alpha-tocotrienol 6
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