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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:elemental hydrogen
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Accession:CHEBI:33260 term browser browse the term


show annotations for term's descendants           Sort by:
dihydrogen term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [Hydrogen co-treated with APP protein] results in increased expression of CAT protein; [Hydrogen co-treated with APP protein] results in increased expression of SOD1 protein; dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]]; dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of and affects the localization of FOXO3 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of CAT mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD2 mRNA]; Hydrogen inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]; Hydrogen inhibits the reaction [APP protein results in increased cleavage of PARP1 protein] CTD PMID:26271894 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Hydrogen inhibits the reaction [APP protein results in increased cleavage of CASP3 protein] CTD PMID:26271894 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
increases expression 		ISO [Hydrogen co-treated with APP protein] results in increased expression of CAT protein; Hydrogen inhibits the reaction [APP protein results in decreased expression of CAT mRNA]
Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of CAT mRNA]
Hydrogen results in increased expression of CAT mRNA; Hydrogen results in increased expression of CAT protein 		CTD PMID:26271894 PMID:32955216 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions EXP Hydrogen inhibits the reaction [nitrofen results in decreased expression of FLT1 mRNA] CTD PMID:34502408 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions
increases expression 		ISO dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of and affects the localization of FOXO3 protein]
Hydrogen results in increased expression of FOXO3 protein 		CTD PMID:26271894 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLC mRNA] CTD PMID:32955216 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLM mRNA] CTD PMID:32955216 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Hydrogen inhibits the reaction [[Chlorpyrifos co-treated with Lipopolysaccharides] results in increased expression of GFAP protein] CTD PMID:30236991 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GPX1 mRNA] CTD PMID:32955216 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP Hydrogen inhibits the reaction [nitrofen results in decreased expression of KDR mRNA] CTD PMID:34502408 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of LDHA mRNA] CTD PMID:32955216 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of NOX4 mRNA] CTD PMID:32955216 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Hydrogen inhibits the reaction [APP protein results in increased cleavage of PARP1 protein] CTD PMID:26271894 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Hydrogen inhibits the reaction [[Chlorpyrifos co-treated with Lipopolysaccharides] results in increased phosphorylation of RELA protein] CTD PMID:30236991 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in increased expression of SCD1 mRNA] CTD PMID:32955216 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sftpa1 surfactant protein A1 multiple interactions EXP Hydrogen inhibits the reaction [nitrofen results in decreased expression of SFTPA1 mRNA] CTD PMID:34502408 NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685 		JBrowse link
G Sirt1 sirtuin 1 increases expression
multiple interactions 		ISO Hydrogen results in increased expression of SIRT1 protein
dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein] 		CTD PMID:26271894 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression 		ISO [Hydrogen co-treated with APP protein] results in increased expression of SOD1 protein; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 protein]
Hydrogen results in increased expression of SOD1 mRNA; Hydrogen results in increased expression of SOD1 protein 		CTD PMID:26271894 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions 		ISO Hydrogen results in increased expression of SOD2 protein
Hydrogen inhibits the reaction [Chlorpyrifos results in increased expression of SOD2 mRNA]
Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD2 mRNA] 		CTD PMID:26271894 PMID:32955216 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Hydrogen inhibits the reaction [Chlorpyrifos promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]] CTD PMID:30236991 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
diprotium term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions ISO [Hydrogen co-treated with APP protein] results in increased expression of CAT protein; [Hydrogen co-treated with APP protein] results in increased expression of SOD1 protein; dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]]; dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of and affects the localization of FOXO3 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of CAT mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD2 mRNA]; Hydrogen inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]; Hydrogen inhibits the reaction [APP protein results in increased cleavage of PARP1 protein] CTD PMID:26271894 NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO Hydrogen inhibits the reaction [APP protein results in increased cleavage of CASP3 protein] CTD PMID:26271894 NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cat catalase multiple interactions
increases expression 		ISO [Hydrogen co-treated with APP protein] results in increased expression of CAT protein; Hydrogen inhibits the reaction [APP protein results in decreased expression of CAT mRNA]
Hydrogen results in increased expression of CAT mRNA; Hydrogen results in increased expression of CAT protein
Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of CAT mRNA] 		CTD PMID:26271894 PMID:32955216 NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Flt1 Fms related receptor tyrosine kinase 1 multiple interactions EXP Hydrogen inhibits the reaction [nitrofen results in decreased expression of FLT1 mRNA] CTD PMID:34502408 NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626 		JBrowse link
G Foxo3 forkhead box O3 multiple interactions
increases expression 		ISO dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of and affects the localization of FOXO3 protein]
Hydrogen results in increased expression of FOXO3 protein 		CTD PMID:26271894 NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLC mRNA] CTD PMID:32955216 NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLM mRNA] CTD PMID:32955216 NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions EXP Hydrogen inhibits the reaction [[Chlorpyrifos co-treated with Lipopolysaccharides] results in increased expression of GFAP protein] CTD PMID:30236991 NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589 		JBrowse link
G Gpx1 glutathione peroxidase 1 multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GPX1 mRNA] CTD PMID:32955216 NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions EXP Hydrogen inhibits the reaction [nitrofen results in decreased expression of KDR mRNA] CTD PMID:34502408 NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Ldha lactate dehydrogenase A multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of LDHA mRNA] CTD PMID:32955216 NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472 		JBrowse link
G Nox4 NADPH oxidase 4 multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of NOX4 mRNA] CTD PMID:32955216 NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Hydrogen inhibits the reaction [APP protein results in increased cleavage of PARP1 protein] CTD PMID:26271894 NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP Hydrogen inhibits the reaction [[Chlorpyrifos co-treated with Lipopolysaccharides] results in increased phosphorylation of RELA protein] CTD PMID:30236991 NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO Hydrogen inhibits the reaction [Chlorpyrifos results in increased expression of SCD1 mRNA] CTD PMID:32955216 NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Sftpa1 surfactant protein A1 multiple interactions EXP Hydrogen inhibits the reaction [nitrofen results in decreased expression of SFTPA1 mRNA] CTD PMID:34502408 NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685 		JBrowse link
G Sirt1 sirtuin 1 increases expression
multiple interactions 		ISO Hydrogen results in increased expression of SIRT1 protein
dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein] 		CTD PMID:26271894 NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
increases expression 		ISO [Hydrogen co-treated with APP protein] results in increased expression of SOD1 protein; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 protein]
Hydrogen results in increased expression of SOD1 mRNA; Hydrogen results in increased expression of SOD1 protein 		CTD PMID:26271894 NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 increases expression
multiple interactions 		ISO Hydrogen results in increased expression of SOD2 protein
Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD2 mRNA]
Hydrogen inhibits the reaction [Chlorpyrifos results in increased expression of SOD2 mRNA] 		CTD PMID:26271894 PMID:32955216 NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions EXP Hydrogen inhibits the reaction [Chlorpyrifos promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]] CTD PMID:30236991 NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 20856
    chemical entity 20854
      molecular entity 20853
        inorganic molecular entity 20592
          elemental hydrogen 20
            dihydrogen + 20
            dihydrogen(.1+) + 0
            monoatomic hydrogen + 0
            trihydrogen(1+) 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 20856
    subatomic particle 20854
      composite particle 20854
        hadron 20854
          baryon 20854
            nucleon 20854
              atomic nucleus 20854
                atom 20854
                  main group element atom 20777
                    main group molecular entity 20777
                      s-block molecular entity 20573
                        hydrogen molecular entity 20557
                          elemental hydrogen 20
                            dihydrogen + 20
                            dihydrogen(.1+) + 0
                            monoatomic hydrogen + 0
                            trihydrogen(1+) 0
paths to the root