|
G
|
App
|
amyloid beta precursor protein
|
multiple interactions
|
ISO
|
[Hydrogen co-treated with APP protein] results in increased expression of CAT protein; [Hydrogen co-treated with APP protein] results in increased expression of SOD1 protein; dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]]; dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of and affects the localization of FOXO3 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of CAT mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD2 mRNA]; Hydrogen inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]; Hydrogen inhibits the reaction [APP protein results in increased cleavage of PARP1 protein]
|
CTD |
PMID:26271894 |
|
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions
|
ISO
|
Hydrogen inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]
|
CTD |
PMID:26271894 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
|
|
G
|
Cat
|
catalase
|
multiple interactions increases expression
|
ISO
|
[Hydrogen co-treated with APP protein] results in increased expression of CAT protein; Hydrogen inhibits the reaction [APP protein results in decreased expression of CAT mRNA] Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of CAT mRNA] Hydrogen results in increased expression of CAT mRNA; Hydrogen results in increased expression of CAT protein
|
CTD |
PMID:26271894 PMID:32955216 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
|
|
G
|
Flt1
|
Fms related receptor tyrosine kinase 1
|
multiple interactions
|
EXP
|
Hydrogen inhibits the reaction [nitrofen results in decreased expression of FLT1 mRNA]
|
CTD |
PMID:34502408 |
|
NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626
|
|
G
|
Foxo3
|
forkhead box O3
|
multiple interactions increases expression
|
ISO
|
dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of and affects the localization of FOXO3 protein] Hydrogen results in increased expression of FOXO3 protein
|
CTD |
PMID:26271894 |
|
NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561
|
|
G
|
Gclc
|
glutamate-cysteine ligase, catalytic subunit
|
multiple interactions
|
ISO
|
Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLC mRNA]
|
CTD |
PMID:32955216 |
|
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
|
|
G
|
Gclm
|
glutamate cysteine ligase, modifier subunit
|
multiple interactions
|
ISO
|
Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLM mRNA]
|
CTD |
PMID:32955216 |
|
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535
|
|
G
|
Gfap
|
glial fibrillary acidic protein
|
multiple interactions
|
EXP
|
Hydrogen inhibits the reaction [[Chlorpyrifos co-treated with Lipopolysaccharides] results in increased expression of GFAP protein]
|
CTD |
PMID:30236991 |
|
NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589
|
|
G
|
Gpx1
|
glutathione peroxidase 1
|
multiple interactions
|
ISO
|
Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GPX1 mRNA]
|
CTD |
PMID:32955216 |
|
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
|
|
G
|
Kdr
|
kinase insert domain receptor
|
multiple interactions
|
EXP
|
Hydrogen inhibits the reaction [nitrofen results in decreased expression of KDR mRNA]
|
CTD |
PMID:34502408 |
|
NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018
|
|
G
|
Ldha
|
lactate dehydrogenase A
|
multiple interactions
|
ISO
|
Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of LDHA mRNA]
|
CTD |
PMID:32955216 |
|
NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472
|
|
G
|
Nox4
|
NADPH oxidase 4
|
multiple interactions
|
ISO
|
Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of NOX4 mRNA]
|
CTD |
PMID:32955216 |
|
NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406
|
|
G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
multiple interactions
|
ISO
|
Hydrogen inhibits the reaction [APP protein results in increased cleavage of PARP1 protein]
|
CTD |
PMID:26271894 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
EXP
|
Hydrogen inhibits the reaction [[Chlorpyrifos co-treated with Lipopolysaccharides] results in increased phosphorylation of RELA protein]
|
CTD |
PMID:30236991 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
|
|
G
|
Scd
|
stearoyl-CoA desaturase
|
multiple interactions
|
ISO
|
Hydrogen inhibits the reaction [Chlorpyrifos results in increased expression of SCD1 mRNA]
|
CTD |
PMID:32955216 |
|
NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
|
|
G
|
Sftpa1
|
surfactant protein A1
|
multiple interactions
|
EXP
|
Hydrogen inhibits the reaction [nitrofen results in decreased expression of SFTPA1 mRNA]
|
CTD |
PMID:34502408 |
|
NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685
|
|
G
|
Sirt1
|
sirtuin 1
|
increases expression multiple interactions
|
ISO
|
Hydrogen results in increased expression of SIRT1 protein dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]
|
CTD |
PMID:26271894 |
|
NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
|
|
G
|
Sod1
|
superoxide dismutase 1
|
multiple interactions increases expression
|
ISO
|
[Hydrogen co-treated with APP protein] results in increased expression of SOD1 protein; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 protein] Hydrogen results in increased expression of SOD1 mRNA; Hydrogen results in increased expression of SOD1 protein
|
CTD |
PMID:26271894 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
|
|
G
|
Sod2
|
superoxide dismutase 2
|
increases expression multiple interactions
|
ISO
|
Hydrogen results in increased expression of SOD2 protein Hydrogen inhibits the reaction [Chlorpyrifos results in increased expression of SOD2 mRNA] Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD2 mRNA]
|
CTD |
PMID:26271894 PMID:32955216 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
|
|
G
|
Tlr4
|
toll-like receptor 4
|
multiple interactions
|
EXP
|
Hydrogen inhibits the reaction [Chlorpyrifos promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]]
|
CTD |
PMID:30236991 |
|
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
|
|
|
G
|
App
|
amyloid beta precursor protein
|
multiple interactions
|
ISO
|
[Hydrogen co-treated with APP protein] results in increased expression of CAT protein; [Hydrogen co-treated with APP protein] results in increased expression of SOD1 protein; dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]]; dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of and affects the localization of FOXO3 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of CAT mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 protein]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD2 mRNA]; Hydrogen inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]; Hydrogen inhibits the reaction [APP protein results in increased cleavage of PARP1 protein]
|
CTD |
PMID:26271894 |
|
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions
|
ISO
|
Hydrogen inhibits the reaction [APP protein results in increased cleavage of CASP3 protein]
|
CTD |
PMID:26271894 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
|
|
G
|
Cat
|
catalase
|
multiple interactions increases expression
|
ISO
|
[Hydrogen co-treated with APP protein] results in increased expression of CAT protein; Hydrogen inhibits the reaction [APP protein results in decreased expression of CAT mRNA] Hydrogen results in increased expression of CAT mRNA; Hydrogen results in increased expression of CAT protein Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of CAT mRNA]
|
CTD |
PMID:26271894 PMID:32955216 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
|
|
G
|
Flt1
|
Fms related receptor tyrosine kinase 1
|
multiple interactions
|
EXP
|
Hydrogen inhibits the reaction [nitrofen results in decreased expression of FLT1 mRNA]
|
CTD |
PMID:34502408 |
|
NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626
|
|
G
|
Foxo3
|
forkhead box O3
|
multiple interactions increases expression
|
ISO
|
dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of FOXO3 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of and affects the localization of FOXO3 protein] Hydrogen results in increased expression of FOXO3 protein
|
CTD |
PMID:26271894 |
|
NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561
|
|
G
|
Gclc
|
glutamate-cysteine ligase, catalytic subunit
|
multiple interactions
|
ISO
|
Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLC mRNA]
|
CTD |
PMID:32955216 |
|
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
|
|
G
|
Gclm
|
glutamate cysteine ligase, modifier subunit
|
multiple interactions
|
ISO
|
Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GCLM mRNA]
|
CTD |
PMID:32955216 |
|
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535
|
|
G
|
Gfap
|
glial fibrillary acidic protein
|
multiple interactions
|
EXP
|
Hydrogen inhibits the reaction [[Chlorpyrifos co-treated with Lipopolysaccharides] results in increased expression of GFAP protein]
|
CTD |
PMID:30236991 |
|
NCBI chr10:88,352,987...88,361,661
Ensembl chr10:87,852,890...87,861,589
|
|
G
|
Gpx1
|
glutathione peroxidase 1
|
multiple interactions
|
ISO
|
Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of GPX1 mRNA]
|
CTD |
PMID:32955216 |
|
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
|
|
G
|
Kdr
|
kinase insert domain receptor
|
multiple interactions
|
EXP
|
Hydrogen inhibits the reaction [nitrofen results in decreased expression of KDR mRNA]
|
CTD |
PMID:34502408 |
|
NCBI chr14:32,572,031...32,615,204
Ensembl chr14:32,217,871...32,261,018
|
|
G
|
Ldha
|
lactate dehydrogenase A
|
multiple interactions
|
ISO
|
Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of LDHA mRNA]
|
CTD |
PMID:32955216 |
|
NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472
|
|
G
|
Nox4
|
NADPH oxidase 4
|
multiple interactions
|
ISO
|
Hydrogen inhibits the reaction [Chlorpyrifos results in decreased expression of NOX4 mRNA]
|
CTD |
PMID:32955216 |
|
NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406
|
|
G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
multiple interactions
|
ISO
|
Hydrogen inhibits the reaction [APP protein results in increased cleavage of PARP1 protein]
|
CTD |
PMID:26271894 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
EXP
|
Hydrogen inhibits the reaction [[Chlorpyrifos co-treated with Lipopolysaccharides] results in increased phosphorylation of RELA protein]
|
CTD |
PMID:30236991 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
|
|
G
|
Scd
|
stearoyl-CoA desaturase
|
multiple interactions
|
ISO
|
Hydrogen inhibits the reaction [Chlorpyrifos results in increased expression of SCD1 mRNA]
|
CTD |
PMID:32955216 |
|
NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
|
|
G
|
Sftpa1
|
surfactant protein A1
|
multiple interactions
|
EXP
|
Hydrogen inhibits the reaction [nitrofen results in decreased expression of SFTPA1 mRNA]
|
CTD |
PMID:34502408 |
|
NCBI chr16:17,008,180...17,011,686
Ensembl chr16:17,008,180...17,011,685
|
|
G
|
Sirt1
|
sirtuin 1
|
increases expression multiple interactions
|
ISO
|
Hydrogen results in increased expression of SIRT1 protein dorsomorphin inhibits the reaction [Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SIRT1 protein]
|
CTD |
PMID:26271894 |
|
NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
|
|
G
|
Sod1
|
superoxide dismutase 1
|
multiple interactions increases expression
|
ISO
|
[Hydrogen co-treated with APP protein] results in increased expression of SOD1 protein; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 mRNA]; Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD1 protein] Hydrogen results in increased expression of SOD1 mRNA; Hydrogen results in increased expression of SOD1 protein
|
CTD |
PMID:26271894 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
|
|
G
|
Sod2
|
superoxide dismutase 2
|
increases expression multiple interactions
|
ISO
|
Hydrogen results in increased expression of SOD2 protein Hydrogen inhibits the reaction [APP protein results in decreased expression of SOD2 mRNA] Hydrogen inhibits the reaction [Chlorpyrifos results in increased expression of SOD2 mRNA]
|
CTD |
PMID:26271894 PMID:32955216 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
|
|
G
|
Tlr4
|
toll-like receptor 4
|
multiple interactions
|
EXP
|
Hydrogen inhibits the reaction [Chlorpyrifos promotes the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]]
|
CTD |
PMID:30236991 |
|
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
|
|