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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:monoatomic entity
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Accession:CHEBI:33238 term browser browse the term
Definition:A monoatomic entity is a molecular entity consisting of a single atom.
Synonyms:related_synonym: atomic entity;   monoatomic entities


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ammonium chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G RUNX2 RUNX family transcription factor 2 multiple interactions EXP Ammonium Chloride inhibits the reaction [SOX5 protein inhibits the reaction [Warfarin results in increased expression of RUNX2 mRNA]] CTD PMID:34520801 NCBI chr 7:40,106,581...40,353,304
Ensembl chr 7:40,106,532...40,460,687 		JBrowse link
G SOX5 SRY-box transcription factor 5 multiple interactions EXP Ammonium Chloride inhibits the reaction [SOX5 protein inhibits the reaction [Warfarin results in increased expression of RUNX2 mRNA]] CTD PMID:34520801 NCBI chr 5:49,159,950...50,166,463
Ensembl chr 5:49,504,551...50,161,558 		JBrowse link
cadmium nitrate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CD14 CD14 molecule affects expression EXP cadmium nitrate affects the expression of CD14 mRNA CTD PMID:29421334 NCBI chr 2:142,348,036...142,349,686
Ensembl chr 2:142,346,360...142,349,581 		JBrowse link
G CXCL8 C-X-C motif chemokine ligand 8 affects expression
affects secretion		 EXP cadmium nitrate affects the expression of CXCL8 mRNA
cadmium nitrate affects the secretion of CXCL8 protein		 CTD PMID:29421334 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G DEFB1 defensin beta 1 increases expression EXP cadmium nitrate results in increased expression of DEFB1 mRNA CTD PMID:29421334
G IFNB1 interferon beta 1 increases expression EXP cadmium nitrate results in increased expression of IFNB1 mRNA CTD PMID:29421334 NCBI chr 1:201,850,935...201,851,495
Ensembl chr 1:201,850,935...201,851,495 		JBrowse link
G IL18 interleukin 18 increases expression EXP cadmium nitrate results in increased expression of IL18 mRNA CTD PMID:29421334 NCBI chr 9:39,839,959...39,861,258
Ensembl chr 9:39,834,973...39,861,219 		JBrowse link
G IL6 interleukin 6 increases expression EXP cadmium nitrate results in increased expression of IL6 mRNA CTD PMID:29421334 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
G LOC110258578 interleukin-1 beta-like increases expression EXP cadmium nitrate results in increased expression of IL1B mRNA CTD PMID:29421334
G MAPK14 mitogen-activated protein kinase 14 affects expression EXP cadmium nitrate affects the expression of MAPK14 mRNA CTD PMID:29421334 NCBI chr 7:31,791,398...31,861,544
Ensembl chr 7:31,790,877...31,862,031 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases expression EXP cadmium nitrate results in increased expression of MAPK8 mRNA CTD PMID:29421334 NCBI chr14:88,988,914...89,108,875
Ensembl chr14:88,988,949...89,108,874 		JBrowse link
G MYD88 MYD88 innate immune signal transduction adaptor affects expression EXP cadmium nitrate affects the expression of MYD88 mRNA CTD PMID:29421334 NCBI chr13:22,976,951...22,979,568
Ensembl chr13:22,966,137...22,983,109 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 affects expression EXP cadmium nitrate affects the expression of NFKB1 mRNA CTD PMID:29421334 NCBI chr 8:118,391,010...118,478,927
Ensembl chr 8:118,390,638...118,506,691 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit increases expression EXP cadmium nitrate results in increased expression of RELA mRNA CTD PMID:29421334 NCBI chr 2:6,594,869...6,602,684
Ensembl chr 2:6,593,969...6,603,469 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 decreases expression EXP cadmium nitrate results in decreased expression of SOCS1 mRNA CTD PMID:29421334 NCBI chr 3:31,879,143...31,883,041
Ensembl chr 3:31,881,225...31,884,967 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 decreases expression EXP cadmium nitrate results in decreased expression of STAT3 mRNA CTD PMID:29421334 NCBI chr12:20,407,316...20,471,091
Ensembl chr12:20,407,233...20,472,992 		JBrowse link
G TLR4 toll like receptor 4 affects expression EXP cadmium nitrate affects the expression of TLR4 mRNA CTD PMID:29421334 NCBI chr 1:258,044,610...258,054,641
Ensembl chr 1:258,044,610...258,058,970 		JBrowse link
G TLR5 toll like receptor 5 increases expression EXP cadmium nitrate results in increased expression of TLR5 mRNA CTD PMID:29421334 NCBI chr10:19,387,666...19,410,024
Ensembl chr10:19,387,666...19,410,024 		JBrowse link
G TNF tumor necrosis factor increases expression EXP cadmium nitrate results in increased expression of TNF mRNA CTD PMID:29421334 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
calcium dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ENPEP glutamyl aminopeptidase multiple interactions EXP Calcium Chloride promotes the reaction [ENPEP protein results in increased hydrolysis of Aspartame] CTD PMID:8141778 NCBI chr 8:111,765,839...111,858,349
Ensembl chr 8:111,748,514...111,858,510 		JBrowse link
G GAPDH glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP [Sodium Bicarbonate co-treated with Calcium Chloride] results in increased activity of GAPDH protein CTD PMID:26582256 NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991 		JBrowse link
cobalt dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AOC1 amine oxidase copper containing 1 affects binding EXP cobaltous chloride binds to AOC1 protein CTD PMID:16842785 NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP cobaltous chloride results in increased expression of HSP90B1 mRNA CTD PMID:17464326 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP cobaltous chloride results in increased expression of HSPA5 mRNA CTD PMID:17464326 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
colforsin daropate hydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADCYAP1 adenylate cyclase activating polypeptide 1 decreases activity EXP Colforsin results in decreased activity of ADCYAP1 protein alternative form CTD PMID:16847435 NCBI chr 6:105,414,628...105,422,294
Ensembl chr 6:105,414,631...105,422,294 		JBrowse link
G ATP7B ATPase copper transporting beta multiple interactions EXP Colforsin inhibits the reaction [Copper binds to ATP7B protein] CTD PMID:21084060 NCBI chr11:15,892,549...15,942,070
Ensembl chr11:15,876,612...15,942,064 		JBrowse link
G CFTR CF transmembrane conductance regulator increases activity EXP Colforsin results in increased activity of CFTR protein CTD PMID:15246976 NCBI chr18:28,627,717...28,818,209
Ensembl chr18:28,627,728...28,817,950 		JBrowse link
G CREB1 cAMP responsive element binding protein 1 multiple interactions
increases phosphorylation		 EXP N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [Colforsin results in increased phosphorylation of CREB1 protein] CTD PMID:17680988 NCBI chr15:110,705,548...110,773,037
Ensembl chr15:110,705,496...110,771,728 		JBrowse link
copper(II) chloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AOC1 amine oxidase copper containing 1 increases activity EXP cupric chloride results in increased activity of AOC1 protein CTD PMID:16842785 NCBI chr18:6,309,583...6,321,016
Ensembl chr18:6,309,594...6,320,974 		JBrowse link
copper(II) sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ATOX1 antioxidant 1 copper chaperone increases expression EXP Copper Sulfate results in increased expression of ATOX1 mRNA CTD PMID:22585802 NCBI chr16:71,299,321...71,314,598
Ensembl chr16:71,299,321...71,314,597 		JBrowse link
G CCNB1 cyclin B1 increases secretion EXP Copper Sulfate results in increased secretion of CCNB1 protein CTD PMID:24521407 NCBI chr16:47,338,239...47,348,385
Ensembl chr16:47,338,110...47,348,377 		JBrowse link
G COX17 cytochrome c oxidase copper chaperone COX17 decreases expression EXP Copper Sulfate results in decreased expression of COX17 mRNA CTD PMID:22585802 NCBI chr13:140,584,286...140,594,636
Ensembl chr13:140,584,363...140,587,621 		JBrowse link
G GHRH growth hormone releasing hormone increases expression EXP Copper Sulfate results in increased expression of GHRH mRNA CTD PMID:21110139 NCBI chr17:40,386,725...40,398,312
Ensembl chr17:40,387,344...40,397,857 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP Copper Sulfate results in increased expression of HSP90B1 mRNA CTD PMID:17464326 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP Copper Sulfate results in increased expression of HSPA5 mRNA CTD PMID:17464326 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G IGF1 insulin like growth factor 1 increases secretion EXP Copper Sulfate results in increased secretion of IGF1 protein CTD PMID:24521407 NCBI chr 5:81,762,027...81,909,253
Ensembl chr 5:81,775,970...81,848,033 		JBrowse link
G SST somatostatin decreases expression EXP Copper Sulfate results in decreased expression of SST mRNA; Copper Sulfate results in decreased expression of SST protein CTD PMID:21110139 NCBI chr13:125,337,560...125,338,742
Ensembl chr13:125,337,418...125,338,850 		JBrowse link
disodium selenite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAK1 BCL2 antagonist/killer 1 multiple interactions EXP Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of BAK1 protein] CTD PMID:26607349 NCBI chr 7:29,808,849...29,815,345 JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
affects expression		 EXP Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of BAX protein]
Sodium Selenite affects the expression of BAX mRNA		 CTD PMID:17342738 PMID:26607349 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140 		JBrowse link
G BCL2 BCL2 apoptosis regulator multiple interactions EXP Sodium Selenite inhibits the reaction [Cadmium Chloride promotes the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein] CTD PMID:26607349 NCBI chr 1:158,337,403...158,518,214
Ensembl chr 1:158,337,522...158,518,879 		JBrowse link
G BCL2L1 BCL2 like 1 affects expression EXP Sodium Selenite affects the expression of BCL2L1 mRNA CTD PMID:17342738 NCBI chr17:35,366,139...35,415,798
Ensembl chr17:35,366,143...35,414,694 		JBrowse link
G CASP3 caspase 3 multiple interactions
decreases expression		 EXP Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of CASP3 protein]
Sodium Selenite results in decreased expression of CASP3 protein		 CTD PMID:15191356 PMID:17342738 PMID:26607349 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CASP9 caspase 9 multiple interactions EXP Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of CASP9 protein] CTD PMID:26607349 NCBI chr 6:74,707,597...74,730,033
Ensembl chr 6:74,706,516...74,730,007 		JBrowse link
G GPX4 glutathione peroxidase 4 increases activity EXP Sodium Selenite results in increased activity of GPX4 protein CTD PMID:10998458 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,931 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 increases expression EXP Sodium Selenite results in increased expression of MAPK1 protein CTD PMID:17342738 NCBI chr14:50,083,079...50,165,528
Ensembl chr14:50,082,896...50,165,513 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 increases expression EXP Sodium Selenite results in increased expression of MAPK3 protein CTD PMID:17342738 NCBI chr 3:18,291,444...18,299,410
Ensembl chr 3:18,291,445...18,299,567 		JBrowse link
G MIR125A microRNA mir-125a multiple interactions EXP Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [[Cadmium Chloride co-treated with MIR125A mRNA mutant form] results in increased expression of CASP9 protein]; Sodium Selenite inhibits the reaction [Cadmium Chloride promotes the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]]; Sodium Selenite inhibits the reaction [Cadmium results in decreased expression of MIR125A mRNA]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in decreased expression of BCL2 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of BAK1 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of BAX protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of CASP3 protein]; Sodium Selenite inhibits the reaction [MIR125A mRNA mutant form results in increased expression of CASP9 protein] CTD PMID:26607349 NCBI chr 6:58,331,566...58,331,645
Ensembl chr 6:58,331,566...58,331,645 		JBrowse link
G POMC proopiomelanocortin multiple interactions EXP Ditiocarb promotes the reaction [Sodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone]]; Sodium Selenite inhibits the reaction [POMC protein results in increased secretion of Hydrocortisone] CTD PMID:21466817 NCBI chr 3:113,661,712...113,668,558
Ensembl chr 3:113,661,004...113,670,418 		JBrowse link
lead diacetate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 increases expression EXP lead acetate results in increased expression of AKT1 mRNA CTD PMID:29273543
G AMH anti-Mullerian hormone decreases expression
multiple interactions		 EXP lead acetate results in decreased expression of AMH mRNA
lead acetate results in decreased expression of and results in decreased secretion of AMH protein		 CTD PMID:29273543 NCBI chr 2:76,415,564...76,418,315
Ensembl chr 2:76,414,427...76,418,312 		JBrowse link
G FSHB follicle stimulating hormone subunit beta multiple interactions EXP lead acetate inhibits the reaction [FSHB protein results in increased chemical synthesis of Estradiol] CTD PMID:29273543 NCBI chr 2:30,395,769...30,399,282
Ensembl chr 2:30,395,018...30,399,274 		JBrowse link
G FSHR follicle stimulating hormone receptor decreases expression EXP lead acetate results in decreased expression of FSHR mRNA CTD PMID:29273543 NCBI chr 3:91,607,236...91,775,255
Ensembl chr 3:91,607,305...91,774,683 		JBrowse link
G HSP90B1 heat shock protein 90 beta family member 1 increases expression EXP lead acetate results in increased expression of HSP90B1 mRNA CTD PMID:17464326 NCBI chr 5:80,511,513...80,531,016
Ensembl chr 5:80,511,506...80,530,991 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression EXP lead acetate results in increased expression of HSPA5 mRNA CTD PMID:17464326 NCBI chr 1:265,930,044...265,934,959
Ensembl chr 1:265,930,045...265,934,894 		JBrowse link
G INHA inhibin subunit alpha multiple interactions EXP lead acetate results in decreased expression of and results in decreased secretion of [INHBB protein binds to INHA protein] CTD PMID:29273543 NCBI chr15:121,581,847...121,586,020
Ensembl chr15:121,580,803...121,586,006 		JBrowse link
G INHBB inhibin subunit beta B decreases expression
multiple interactions		 EXP lead acetate results in decreased expression of INHBB mRNA
lead acetate results in decreased expression of and results in decreased secretion of [INHBB protein binds to INHA protein]; lead acetate results in decreased expression of and results in decreased secretion of INHBB protein		 CTD PMID:29273543 NCBI chr15:30,999,994...31,004,405
Ensembl chr15:30,999,520...31,004,405 		JBrowse link
G MTOR mechanistic target of rapamycin kinase increases expression EXP lead acetate results in increased expression of MTOR mRNA CTD PMID:29273543 NCBI chr 6:71,286,989...71,412,913
Ensembl chr 6:71,286,989...71,412,888 		JBrowse link
methoctramine tetrahydrochloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHRM2 cholinergic receptor muscarinic 2 multiple interactions EXP methoctramine inhibits the reaction [Quinuclidinyl Benzilate binds to CHRM2 protein] CTD PMID:8744975 NCBI chr18:12,455,139...12,600,314
Ensembl chr18:12,455,145...12,600,186 		JBrowse link
monosodium L-glutamate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACACA acetyl-CoA carboxylase alpha increases expression
multiple interactions		 EXP Sodium Glutamate results in increased expression of ACACA mRNA
Dietary Fats inhibits the reaction [Sodium Glutamate results in increased expression of ACACA mRNA]		 CTD PMID:31360149 NCBI chr12:38,580,916...38,875,067
Ensembl chr12:38,581,457...38,824,712 		JBrowse link
G ACOX1 acyl-CoA oxidase 1 increases expression EXP Sodium Glutamate results in increased expression of ACOX1 mRNA CTD PMID:31360149 NCBI chr12:5,450,913...5,479,550
Ensembl chr12:5,439,361...5,479,546 		JBrowse link
G FASN fatty acid synthase multiple interactions
increases expression		 EXP Dietary Fats inhibits the reaction [Sodium Glutamate results in increased expression of FASN mRNA] CTD PMID:31360149 NCBI chr12:922,405...937,560
Ensembl chr12:920,509...937,561 		JBrowse link
G FFAR2 free fatty acid receptor 2 multiple interactions
affects expression		 EXP Dietary Fats affects the reaction [Sodium Glutamate affects the expression of FFAR2 mRNA]; Sodium Glutamate affects the reaction [Dietary Fats affects the expression of FFAR2 mRNA] CTD PMID:31360149 NCBI chr 6:44,899,879...44,904,461
Ensembl chr 6:44,901,159...44,904,459 		JBrowse link
G FFAR4 free fatty acid receptor 4 affects expression
multiple interactions		 EXP Sodium Glutamate affects the expression of FFAR4 mRNA
Dietary Fats affects the reaction [Sodium Glutamate affects the expression of FFAR4 mRNA]; Sodium Glutamate affects the reaction [Dietary Fats affects the expression of FFAR4 mRNA]		 CTD PMID:31360149 Ensembl chr14:105,011,942...105,037,498 JBrowse link
G GPR119 G protein-coupled receptor 119 affects expression
multiple interactions		 EXP Sodium Glutamate affects the expression of GPR119 mRNA
Dietary Fats affects the reaction [Sodium Glutamate affects the expression of GPR119 mRNA]; Sodium Glutamate affects the reaction [Dietary Fats affects the expression of GPR119 mRNA]		 CTD PMID:31360149 NCBI chr  X:106,872,225...106,873,299
Ensembl chr  X:106,872,225...106,873,299 		JBrowse link
G LOC110255234 liver carboxylesterase-like multiple interactions EXP Sodium Glutamate inhibits the reaction [Dietary Fats results in decreased expression of CES1 mRNA] CTD PMID:31360149
G PNPLA2 patatin like phospholipase domain containing 2 increases expression EXP Sodium Glutamate results in increased expression of PNPLA2 mRNA CTD PMID:31360149 NCBI chr 2:513,065...517,962
Ensembl chr 2:513,077...518,182 		JBrowse link
G SREBF1 sterol regulatory element binding transcription factor 1 multiple interactions
increases expression		 EXP Dietary Fats inhibits the reaction [Sodium Glutamate results in increased expression of SREBF1 mRNA] CTD PMID:31360149 NCBI chr12:60,733,967...60,750,951
Ensembl chr12:60,733,907...60,751,267 		JBrowse link
potassium chromate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GAPDH glyceraldehyde-3-phosphate dehydrogenase decreases activity EXP potassium chromate(VI) results in decreased activity of GAPDH protein CTD PMID:26582256 NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991 		JBrowse link
potassium hexacyanoferrate(3-) term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G NOS3 nitric oxide synthase 3 decreases activity EXP potassium ferricyanide results in decreased activity of NOS3 protein CTD PMID:8810647 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
sodium arsenite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 increases degradation
multiple interactions
decreases expression		 EXP sodium arsenite results in increased degradation of AKT1 protein
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of AKT1 protein]; sodium arsenite results in decreased expression of and results in increased phosphorylation of AKT1 protein; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]
sodium arsenite results in decreased expression of AKT1 protein		 CTD PMID:12760830 PMID:16239170
G HIF1A hypoxia inducible factor 1 subunit alpha multiple interactions
increases expression		 EXP bisindolylmaleimide I inhibits the reaction [sodium arsenite results in increased expression of HIF1A mRNA]; Go 6976 inhibits the reaction [sodium arsenite results in increased expression of HIF1A mRNA]
sodium arsenite results in increased expression of HIF1A mRNA; sodium arsenite results in increased expression of HIF1A protein		 CTD PMID:15089098 NCBI chr 1:190,625,436...190,673,926
Ensembl chr 1:190,625,244...190,674,845 		JBrowse link
G MAPK6 mitogen-activated protein kinase 6 increases expression EXP sodium arsenite results in increased expression of MAPK6 protein CTD PMID:12760830 NCBI chr 1:119,725,026...119,770,988
Ensembl chr 1:119,725,029...119,771,312 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions
increases degradation
decreases expression		 EXP 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of NOS3 protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in increased degradation of NOS3 protein]; sodium arsenite results in increased phosphorylation of and results in decreased activity of NOS3 protein; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of NOS3 protein]
sodium arsenite results in decreased expression of NOS3 protein		 CTD PMID:16239170 NCBI chr18:6,209,218...6,228,912
Ensembl chr18:6,209,158...6,228,943 		JBrowse link
G PRKACA protein kinase cAMP-activated catalytic subunit alpha decreases expression EXP sodium arsenite results in decreased expression of PRKACA protein CTD PMID:12760830 NCBI chr 2:65,074,876...65,095,564
Ensembl chr 2:65,074,870...65,095,551 		JBrowse link
G PRKCD protein kinase C delta increases phosphorylation EXP sodium arsenite results in increased phosphorylation of PRKCD protein CTD PMID:15089098 NCBI chr13:35,290,835...35,323,245
Ensembl chr13:35,290,610...35,323,356 		JBrowse link
G RPS6KA1 ribosomal protein S6 kinase A1 decreases expression EXP sodium arsenite results in decreased expression of RPS6KA1 protein CTD PMID:12760830 NCBI chr 6:83,905,124...83,947,189
Ensembl chr 6:83,905,077...83,950,963 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions
increases activity		 EXP [sodium arsenite results in increased activity of SOD1 protein] which results in increased abundance of Hydrogen Peroxide CTD PMID:12530527 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729 		JBrowse link
G TP53 tumor protein p53 increases expression EXP sodium arsenite results in increased expression of TP53 CTD PMID:13129816 NCBI chr12:52,939,643...52,953,786
Ensembl chr12:52,939,644...52,953,818 		JBrowse link
G VEGFA vascular endothelial growth factor A increases expression
multiple interactions		 EXP sodium arsenite results in increased expression of VEGFA mRNA
bisindolylmaleimide I inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; R 59949 promotes the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; sodium arsenite results in increased expression of and results in increased secretion of VEGFA protein		 CTD PMID:15089098 NCBI chr 7:38,746,393...38,762,282
Ensembl chr 7:38,746,052...38,761,366 		JBrowse link
sodium benzoate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DAO D-amino acid oxidase decreases activity EXP Sodium Benzoate results in decreased activity of DAO protein CTD PMID:20952482 NCBI chr14:41,931,549...41,950,628
Ensembl chr14:41,931,541...41,950,633 		JBrowse link
sodium borohydride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CCL2 chemokine (C-C motif) ligand 2 multiple interactions EXP sodium borohydride inhibits the reaction [[2,2'-azobis(2-amidinopropane) results in increased oxidation of Docosahexaenoic Acids] inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CCL2 mRNA]] CTD PMID:21130106 NCBI chr12:40,798,109...40,800,013
Ensembl chr12:40,798,109...40,800,026 		JBrowse link
sodium dichromate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKT1 AKT serine/threonine kinase 1 decreases expression EXP sodium bichromate results in decreased expression of AKT1 protein CTD PMID:12760830
sodium disulfite term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CXCL8 C-X-C motif chemokine ligand 8 multiple interactions EXP sodium metabisulfite inhibits the reaction [deoxynivalenol results in increased expression of CXCL8 mRNA] CTD PMID:33817499 NCBI chr 8:69,932,646...69,935,861
Ensembl chr 8:69,932,643...69,935,861 		JBrowse link
G IL6 interleukin 6 multiple interactions EXP sodium metabisulfite inhibits the reaction [deoxynivalenol results in increased expression of IL6 mRNA] CTD PMID:33817499 NCBI chr 9:91,506,421...91,510,830
Ensembl chr 9:91,506,421...91,511,263 		JBrowse link
sodium hydrogencarbonate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GAPDH glyceraldehyde-3-phosphate dehydrogenase multiple interactions EXP [Sodium Bicarbonate co-treated with Calcium Chloride] results in increased activity of GAPDH protein CTD PMID:26582256 NCBI chr 5:64,129,678...64,135,194
Ensembl chr 5:64,129,679...64,133,991 		JBrowse link
sodium iodide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC5A5 solute carrier family 5 member 5 multiple interactions
increases uptake		 EXP sodium perchlorate inhibits the reaction [SLC5A5 protein alternative form results in increased uptake of Sodium Iodide]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide]
SLC5A5 protein alternative form results in increased uptake of Sodium Iodide; SLC5A5 protein results in increased uptake of Sodium Iodide		 CTD PMID:12586784 NCBI chr 2:59,869,157...59,885,086
Ensembl chr 2:59,869,155...59,885,266 		JBrowse link
sodium perchlorate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC5A5 solute carrier family 5 member 5 multiple interactions EXP sodium perchlorate inhibits the reaction [SLC5A5 protein alternative form results in increased uptake of Sodium Iodide]; sodium perchlorate inhibits the reaction [SLC5A5 protein results in increased uptake of Sodium Iodide] CTD PMID:12586784 NCBI chr 2:59,869,157...59,885,086
Ensembl chr 2:59,869,155...59,885,266 		JBrowse link
G TPO thyroid peroxidase decreases activity EXP sodium perchlorate results in decreased activity of TPO protein CTD PMID:23959146 NCBI chr 3:132,384,677...132,409,750
Ensembl chr 3:132,384,583...132,409,208 		JBrowse link
zinc dichloride term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PSP-I porcine seminal protein I multiple interactions
affects folding		 EXP zinc chloride promotes the reaction [PSP-I protein binds to Heparin]
zinc chloride affects the folding of PSP-I protein		 CTD PMID:16819821 NCBI chr14:132,302,376...132,309,388
Ensembl chr14:132,302,352...132,308,106 		JBrowse link
zinc sulfate term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator increases expression
multiple interactions		 EXP Zinc Sulfate results in increased expression of BAX mRNA
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BAX mRNA]		 CTD PMID:28803810 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140 		JBrowse link
G BECN1 beclin 1 increases expression
multiple interactions		 EXP Zinc Sulfate results in increased expression of BECN1 protein
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of BECN1 protein]		 CTD PMID:28803810 NCBI chr12:20,041,914...20,054,249
Ensembl chr12:20,041,956...20,054,373 		JBrowse link
G CASP3 caspase 3 multiple interactions
increases expression
increases cleavage		 EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP3 protein]
Zinc Sulfate results in increased expression of CASP3 mRNA		 CTD PMID:28803810 NCBI chr15:45,744,320...45,753,252
Ensembl chr15:45,742,751...45,764,213 		JBrowse link
G CASP6 caspase 6 increases expression EXP Zinc Sulfate results in increased expression of CASP6 mRNA CTD PMID:28803810 NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,520,629...112,537,045 		JBrowse link
G CASP8 caspase 8 multiple interactions
increases cleavage		 EXP 3-methyladenine inhibits the reaction [Zinc Sulfate results in increased cleavage of CASP8 protein] CTD PMID:28803810 NCBI chr15:104,923,659...104,948,470
Ensembl chr15:104,923,953...104,948,468 		JBrowse link
G CYCS cytochrome c, somatic increases expression
multiple interactions		 EXP Zinc Sulfate results in increased expression of CYCS mRNA
3-methyladenine inhibits the reaction [Zinc Sulfate results in increased expression of CYCS mRNA]		 CTD PMID:28803810 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866 		JBrowse link
G GPX1 glutathione peroxidase 1 multiple interactions EXP Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of GPX1 mRNA] CTD PMID:32280687 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,916,246...31,917,433 		JBrowse link
G LOC110258578 interleukin-1 beta-like multiple interactions EXP Zinc Sulfate inhibits the reaction [Diquat results in increased expression of IL1B mRNA] CTD PMID:32280687
G MAP1LC3A microtubule associated protein 1 light chain 3 alpha increases expression EXP Zinc Sulfate results in increased expression of MAP1LC3A mRNA CTD PMID:28803810 NCBI chr17:37,957,830...37,959,505
Ensembl chr17:37,957,507...37,959,505 		JBrowse link
G MT1A metallothionein 1A increases expression EXP Zinc Sulfate results in increased expression of MT1A mRNA CTD PMID:25895165 NCBI chr 6:18,672,016...18,673,673
Ensembl chr 6:18,672,001...18,673,672 		JBrowse link
G NFE2L2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of NFE2L2 mRNA] CTD PMID:32280687 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,656...83,146,183 		JBrowse link
G SLC30A1 solute carrier family 30 member 1 increases expression EXP Zinc Sulfate results in increased expression of SLC30A1 mRNA CTD PMID:25895165 NCBI chr 9:131,633,586...131,636,934
Ensembl chr 9:131,633,585...131,640,672 		JBrowse link
G SLC39A10 solute carrier family 39 member 10 decreases expression
increases expression		 EXP Zinc Sulfate results in decreased expression of SLC39A10 mRNA
Zinc Sulfate results in increased expression of SLC39A10 mRNA		 CTD PMID:16804107 NCBI chr15:99,584,830...99,724,621
Ensembl chr15:99,584,872...99,724,611 		JBrowse link
G SOD1 superoxide dismutase 1 multiple interactions EXP Zinc Sulfate inhibits the reaction [Diquat results in decreased expression of SOD1 mRNA] CTD PMID:32280687 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,729 		JBrowse link
G SQSTM1 sequestosome 1 increases expression
multiple interactions
decreases expression		 EXP Zinc Sulfate results in increased expression of SQSTM1 mRNA
3-methyladenine inhibits the reaction [Zinc Sulfate results in decreased expression of SQSTM1 protein]		 CTD PMID:28803810 NCBI chr 2:78,752,768...78,763,998
Ensembl chr 2:78,752,771...78,763,938 		JBrowse link
G TNF tumor necrosis factor multiple interactions EXP Zinc Sulfate inhibits the reaction [Diquat results in increased expression of TNF mRNA] CTD PMID:32280687 NCBI chr 7:23,699,635...23,702,393
Ensembl chr 7:23,699,628...23,702,416 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5033
    chemical entity 5033
      molecular entity 5032
        elemental molecular entity 142
          monoatomic entity 87
            monoatomic aluminium + 0
            monoatomic argon + 0
            monoatomic beryllium + 0
            monoatomic boron + 0
            monoatomic carbon + 0
            monoatomic halogen + 13
            monoatomic helium + 0
            monoatomic hydrogen + 0
            monoatomic ion + 87
            monoatomic krypton + 0
            monoatomic neon + 0
            monoatomic nitrogen + 0
            monoatomic oxygen + 0
            monoatomic phosphorus + 0
            monoatomic radon + 0
            monoatomic sulfur + 0
            monoatomic xenon + 0
paths to the root