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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:tocotrienol
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Accession:CHEBI:33235 term browser browse the term
Definition:A tocol in which the hydrocarbon chain at position 2 contains three double bonds.
Synonyms:related_synonym: tocotrienols
 xref: CAS:6829-55-6;   PMID:15671205;   PMID:18997413;   Reaxys:19981754;   Wikipedia:Tocotrienol


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alpha-tocotrienol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO tocotrienol, alpha results in increased expression of ABCB1 CTD PMID:15269186 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 affects response to substance
multiple interactions
ISO CYP3A5 gene polymorphism affects the susceptibility to tocotrienol, alpha
tocotrienol, alpha inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; tocotrienol, alpha inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]
CTD PMID:31102695 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Gstm1 glutathione S-transferase mu 1 multiple interactions ISO GSTM1 gene polymorphism affects the susceptibility to [Ascorbic Acid co-treated with tocotrienol, alpha] CTD PMID:15668500 NCBI chr 2:210,803,869...210,809,461
Ensembl chr 2:210,803,869...210,809,306
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO tocotrienol, alpha inhibits the reaction [NR1I2 protein binds to NCOR1 protein] CTD PMID:15269186 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO tocotrienol, alpha binds to and results in increased activity of NR1I2 protein; tocotrienol, alpha inhibits the reaction [NR1I2 protein binds to NCOR1 protein] CTD PMID:15269186 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO tocotrienol, alpha results in increased expression of UGT1A1 CTD PMID:15269186 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
beta-tocotrienol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO tocotrienol, beta results in increased expression of ABCB1 CTD PMID:15269186 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO tocotrienol, beta inhibits the reaction [NR1I2 protein binds to NCOR1 protein] CTD PMID:15269186 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO tocotrienol, beta binds to and results in increased activity of NR1I2 protein; tocotrienol, beta inhibits the reaction [NR1I2 protein binds to NCOR1 protein] CTD PMID:15269186 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO tocotrienol, beta results in increased expression of UGT1A1 CTD PMID:15269186 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
delta-tocotrienol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO tocotrienol, delta results in increased expression of ABCB1 CTD PMID:15269186 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions
increases expression
ISO tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of ABCC1 mRNA]
tocotrienol, delta results in increased expression of ABCC1 mRNA
CTD PMID:22185406 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Abcd2 ATP binding cassette subfamily D member 2 decreases expression ISO tocotrienol, delta results in decreased expression of ABCD2 mRNA CTD PMID:22185406 NCBI chr 7:132,294,564...132,343,169
Ensembl chr 7:132,294,562...132,343,169
JBrowse link
G Actl6b actin-like 6B increases expression ISO tocotrienol, delta results in increased expression of ACTL6B mRNA CTD PMID:22185406 NCBI chr12:22,194,595...22,211,107
Ensembl chr12:22,194,618...22,211,080
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions
increases expression
ISO tocotrienol, delta promotes the reaction [Lipopolysaccharides results in increased expression of ATP2A2 mRNA]
tocotrienol, delta results in increased expression of ATP2A2 mRNA
CTD PMID:22185406 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO tocotrienol, delta results in decreased expression of CCND1 protein CTD PMID:21453743 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 multiple interactions
increases expression
ISO tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CCND2 mRNA]
tocotrienol, delta results in increased expression of CCND2 mRNA
CTD PMID:22185406 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Cd40 CD40 molecule multiple interactions
increases expression
ISO tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CD40 mRNA]
tocotrienol, delta results in increased expression of CD40 mRNA
CTD PMID:22185406 NCBI chr 3:161,519,789...161,534,943
Ensembl chr 3:161,519,743...161,534,704
JBrowse link
G Cd69 Cd69 molecule multiple interactions
increases expression
ISO tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of CD69 mRNA]
tocotrienol, delta results in increased expression of CD69 mRNA
CTD PMID:22185406 NCBI chr 4:163,041,147...163,049,065
Ensembl chr 4:163,041,141...163,049,084
JBrowse link
G Cox7b2 cytochrome c oxidase subunit 7B2 multiple interactions
decreases expression
ISO tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of COX7B2 mRNA]
tocotrienol, delta results in decreased expression of COX7B2 mRNA
CTD PMID:22185406 NCBI chr14:39,256,685...39,368,886
Ensembl chr14:39,368,530...39,368,769
JBrowse link
G Crp C-reactive protein multiple interactions ISO [resveratrol co-treated with pterostilbene co-treated with Quercetin co-treated with tocotrienol, delta co-treated with Niacin] results in decreased expression of CRP protein CTD PMID:24319627 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Ctnnb1 catenin beta 1 decreases expression ISO tocotrienol, delta results in decreased expression of CTNNB1 protein CTD PMID:21453743 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions
affects response to substance
ISO tocotrienol, delta inhibits the reaction [CYP3A5 protein results in increased hydroxylation of Testosterone]; tocotrienol, delta inhibits the reaction [CYP3A5 protein results in increased oxidation of Lithocholic Acid]
CYP3A5 gene polymorphism affects the susceptibility to tocotrienol, delta
CTD PMID:31102695 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
JBrowse link
G Gimap1 GTPase, IMAP family member 1 multiple interactions
decreases expression
ISO tocotrienol, delta promotes the reaction [Lipopolysaccharides results in decreased expression of GIMAP1 mRNA]
tocotrienol, delta results in decreased expression of GIMAP1 mRNA
CTD PMID:22185406 NCBI chr 4:78,365,276...78,375,450
Ensembl chr 4:78,371,121...78,375,223
JBrowse link
G Icam1 intercellular adhesion molecule 1 decreases expression
multiple interactions
ISO tocotrienol, delta results in decreased expression of ICAM1 mRNA
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of ICAM1 mRNA]
CTD PMID:22185406 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO tocotrienol, delta inhibits the reaction [[IFNB1 protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] CTD PMID:22185406 NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
JBrowse link
G Ifng interferon gamma multiple interactions ISO tocotrienol, delta inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased abundance of Nitric Oxide] CTD PMID:22185406 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Ifngr1 interferon gamma receptor 1 decreases expression
multiple interactions
ISO tocotrienol, delta results in decreased expression of IFNGR1 mRNA
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of IFNGR1 mRNA]
CTD PMID:22185406 NCBI chr 1:15,062,380...15,080,815
Ensembl chr 1:15,062,432...15,080,907
JBrowse link
G Il12b interleukin 12B decreases expression
multiple interactions
ISO tocotrienol, delta results in decreased expression of IL12B mRNA
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]
CTD PMID:22185406 NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
JBrowse link
G Il1a interleukin 1 alpha increases expression ISO tocotrienol, delta results in increased expression of IL1A mRNA CTD PMID:22185406 NCBI chr 3:121,824,712...121,836,122
Ensembl chr 3:121,825,412...121,836,086
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
tocotrienol, delta results in increased expression of IL1B mRNA
CTD PMID:22185406 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist increases expression
multiple interactions
ISO tocotrienol, delta results in increased expression of IL1RN mRNA
tocotrienol, delta promotes the reaction [Lipopolysaccharides results in increased expression of IL1RN mRNA]
CTD PMID:22185406 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il6 interleukin 6 increases expression
multiple interactions
ISO tocotrienol, delta results in increased expression of IL6 mRNA
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]
CTD PMID:22185406 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit decreases expression ISO tocotrienol, delta results in decreased expression of JUN protein CTD PMID:21453743 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO tocotrienol, delta results in decreased expression of MMP7 protein CTD PMID:21453743 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
JBrowse link
G Ncor1 nuclear receptor co-repressor 1 multiple interactions ISO tocotrienol, delta inhibits the reaction [NR1I2 protein binds to NCOR1 protein] CTD PMID:15269186 NCBI chr10:48,629,121...48,772,890
Ensembl chr10:48,629,121...48,772,890
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Lipopolysaccharides inhibits the reaction [tocotrienol, delta results in increased expression of NOS2]; tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA] CTD PMID:21356098 PMID:22185406 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions ISO tocotrienol, delta binds to and results in increased activity of NR1I2 protein; tocotrienol, delta inhibits the reaction [NR1I2 protein binds to NCOR1 protein] CTD PMID:15269186 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Phka2 phosphorylase kinase regulatory subunit alpha 2 multiple interactions
increases expression
ISO tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of PHKA2 mRNA]
tocotrienol, delta results in increased expression of PHKA2 mRNA
CTD PMID:22185406 NCBI chr  X:35,970,650...36,926,616 JBrowse link
G Psmb2 proteasome 20S subunit beta 2 decreases expression ISO tocotrienol, delta results in decreased expression of PSMB2 mRNA CTD PMID:22185406 NCBI chr 5:144,702,004...144,734,220
Ensembl chr 5:144,701,949...144,734,257
JBrowse link
G Ptbp2 polypyrimidine tract binding protein 2 multiple interactions
increases expression
ISO tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of PTBP2 mRNA]
tocotrienol, delta results in increased expression of PTBP2 mRNA
CTD PMID:22185406 NCBI chr 2:223,261,444...223,323,075
Ensembl chr 2:223,262,852...223,322,585
JBrowse link
G Rasgrp1 RAS guanyl releasing protein 1 multiple interactions
increases expression
ISO tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of RASGRP1 mRNA]
tocotrienol, delta results in increased expression of RASGRP1 mRNA
CTD PMID:22185406 NCBI chr 3:108,984,029...109,044,420
Ensembl chr 3:108,984,029...109,044,420
JBrowse link
G Rasgrp3 RAS guanyl releasing protein 3 decreases expression
multiple interactions
ISO tocotrienol, delta results in decreased expression of RASGRP3 mRNA
tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of RASGRP3 mRNA]
CTD PMID:22185406 NCBI chr 6:21,072,634...21,171,619
Ensembl chr 6:21,072,634...21,135,880
JBrowse link
G Socs3 suppressor of cytokine signaling 3 multiple interactions
decreases expression
ISO tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of SOCS3 mRNA]
tocotrienol, delta results in decreased expression of SOCS3 mRNA
CTD PMID:22185406 NCBI chr10:106,973,863...106,976,969
Ensembl chr10:106,975,178...106,976,040
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO Lipopolysaccharides inhibits the reaction [tocotrienol, delta results in increased expression of TNF]; tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
tocotrienol, delta results in decreased expression of TNF mRNA
CTD PMID:21356098 PMID:22185406 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tnp1 transition protein 1 multiple interactions
decreases expression
ISO tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of TNP1 mRNA]
tocotrienol, delta results in decreased expression of TNP1 mRNA
CTD PMID:22185406 NCBI chr 9:80,294,837...80,295,446
Ensembl chr 9:80,294,840...80,295,446
JBrowse link
G Traf1 TNF receptor-associated factor 1 multiple interactions
increases expression
ISO tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF1 mRNA]
tocotrienol, delta results in increased expression of TRAF1 mRNA
CTD PMID:22185406 NCBI chr 3:14,003,340...14,022,955
Ensembl chr 3:14,003,340...14,022,672
JBrowse link
G Ube2d2 ubiquitin-conjugating enzyme E2D 2 multiple interactions
decreases expression
ISO tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in decreased expression of UBE2D2A mRNA]
tocotrienol, delta results in decreased expression of UBE2D2A mRNA
CTD PMID:22185406 NCBI chr18:28,561,957...28,603,335
Ensembl chr18:28,594,892...28,603,335
JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO tocotrienol, delta results in increased expression of UGT1A1 CTD PMID:15269186 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions
decreases expression
ISO tocotrienol, delta inhibits the reaction [Lipopolysaccharides results in increased expression of VCAM1 mRNA]
tocotrienol, delta results in decreased expression of VCAM1 mRNA
CTD PMID:22185406 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link
G Wnt1 Wnt family member 1 decreases expression ISO tocotrienol, delta results in decreased expression of WNT1 protein CTD PMID:21453743 NCBI chr 7:140,464,999...140,469,046
Ensembl chr 7:140,464,999...140,469,046
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      chemical role 19283
        antioxidant 14226
          tocol 250
            tocotrienol 42
              (R)-Sargachromenol 0
              (S)-Sargachromenol 0
              13'-carboxy-alpha-tocotrienol 0
              13'-carboxy-gamma-tocotrienol 0
              13'-hydroxy-alpha-tocotrienol 0
              I(3)-Tocotrienol 0
              alpha-tocotrienol 6
              beta-tocotrienol 4
              delta-tocotrienol 41
              desmethyl tocotrienol 0
              didesmethyl tocotrienol 0
              gamma-tocotrienol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  oxacycle 17200
                                    benzopyran 10149
                                      1-benzopyran 9865
                                        chromanes 3918
                                          chromanol 1725
                                            chroman-6-ol 1725
                                              tocol 250
                                                tocotrienol 42
                                                  (R)-Sargachromenol 0
                                                  (S)-Sargachromenol 0
                                                  13'-carboxy-alpha-tocotrienol 0
                                                  13'-carboxy-gamma-tocotrienol 0
                                                  13'-hydroxy-alpha-tocotrienol 0
                                                  I(3)-Tocotrienol 0
                                                  alpha-tocotrienol 6
                                                  beta-tocotrienol 4
                                                  delta-tocotrienol 41
                                                  desmethyl tocotrienol 0
                                                  didesmethyl tocotrienol 0
                                                  gamma-tocotrienol 0
paths to the root