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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:vitamin E
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Accession:CHEBI:33234 term browser browse the term
Definition:Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.
Synonyms:related_synonym: vitamin E vitamer;   vitamin E vitamers;   vitamins E
 alt_id: MESH:D014810
 xref_mesh: MESH:D024502
 xref: MetaCyc:Vitamin-E;   PMID:33684201;   PMID:33847203;   PMID:33896432;   PMID:34277234;   PMID:34278890;   PMID:7898412;   PMID:7901680;   Wikipedia:Vitamin_E


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vitamin E term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G BAX BCL2 associated X, apoptosis regulator multiple interactions EXP Vitamin E inhibits the reaction [Cyclosporine affects the localization of BAX protein] CTD PMID:19523970 NCBI chr 6:54,222,341...54,228,150
Ensembl chr 6:54,222,336...54,228,140 		JBrowse link
G CASP6 caspase 6 multiple interactions EXP Vitamin E inhibits the reaction [Cyclosporine results in increased expression of CASP6 mRNA] CTD PMID:19523970 NCBI chr 8:112,519,450...112,534,315
Ensembl chr 8:112,520,629...112,537,045 		JBrowse link
G CYCS cytochrome c, somatic multiple interactions EXP Vitamin E inhibits the reaction [Cyclosporine affects the localization of CYCS protein] CTD PMID:23347876 NCBI chr18:47,169,921...47,172,212
Ensembl chr18:47,169,866...47,173,866 		JBrowse link
G FGD4 FYVE, RhoGEF and PH domain containing 4 multiple interactions EXP Vitamin E inhibits the reaction [Cyclosporine results in increased expression of DNM1L protein] CTD PMID:23347876 NCBI chr 5:41,571,054...41,636,058
Ensembl chr 5:41,570,282...41,636,028 		JBrowse link
G MFN2 mitofusin 2 multiple interactions EXP Vitamin E inhibits the reaction [Cyclosporine results in decreased expression of MFN2 protein] CTD PMID:23347876 NCBI chr 6:72,026,512...72,056,439
Ensembl chr 6:72,028,499...72,056,438 		JBrowse link
G OPA1 OPA1 mitochondrial dynamin like GTPase multiple interactions EXP Vitamin E inhibits the reaction [Cyclosporine results in decreased expression of OPA1 protein] CTD PMID:23347876 NCBI chr13:130,624,771...130,718,345
Ensembl chr13:130,624,796...130,719,083 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions EXP Vitamin E inhibits the reaction [Linoleic Acid results in increased activity of PPARG protein] CTD PMID:15051824 NCBI chr13:68,301,566...68,433,951
Ensembl chr13:68,302,322...68,433,944 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 5052
    role 5044
      chemical role 824
        antioxidant 348
          vitamin E 7
            alpha-tocopherol + 0
            alpha-tocotrienol 0
            beta-tocopherol 0
            beta-tocotrienol 0
            corn oil 0
            delta-tocopherol 0
            delta-tocotrienol 0
            gamma-tocopherol + 0
            gamma-tocotrienol 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 5052
    subatomic particle 5043
      composite particle 5043
        hadron 5071
          baryon 5043
            nucleon 5043
              atomic nucleus 5043
                atom 5043
                  main group element atom 5013
                    p-block element atom 5010
                      carbon group element atom 4927
                        carbon atom 4954
                          organic molecular entity 4926
                            organic molecule 4874
                              organic cyclic compound 4812
                                organic heterocyclic compound 4626
                                  oxacycle 4522
                                    benzopyran 139
                                      1-benzopyran 78
                                        chromanes 28
                                          chromanol 7
                                            chroman-6-ol 7
                                              vitamin E 7
                                                alpha-tocopherol + 0
                                                alpha-tocotrienol 0
                                                beta-tocopherol 0
                                                beta-tocotrienol 0
                                                corn oil 0
                                                delta-tocopherol 0
                                                delta-tocotrienol 0
                                                gamma-tocopherol + 0
                                                gamma-tocotrienol 0
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