2-thiobarbituric acid - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	2-thiobarbituric acid	go back to main search page
Accession:	CHEBI:33202	browse the term
Definition:	A barbiturate, the structure of which is that of barbituric acid in which the oxygen at C-2 is replaced by sulfur.
Synonyms:	exact_synonym:	2-sulfanylidenedihydropyrimidine-4,6(1H,5H)-dione
	related_synonym:	2-thioxodihydropyrimidine-4,6(1H,5H)-dione; Formula=C4H4N2O2S; InChI=1S/C4H4N2O2S/c7-2-1-3(8)6-4(9)5-2/h1H2,(H2,5,6,7,8,9); InChIKey=RVBUGGBMJDPOST-UHFFFAOYSA-N; SMILES=O=C1CC(=O)NC(=S)N1; dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione; thiobarbituric acid
	xref:	CAS:504-17-6; Gmelin:101333; PMID:18401456; PMID:22467201; PMID:22506924; PMID:23411186; PMID:23523734; PMID:23792287; PMID:23832025; PMID:23896130; PMID:3654008; Reaxys:120663; Wikipedia:Thiobarbituric_acid

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Genes (20)

thiopental

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

angiotensinogen

increases expression

Thiopental results in increased expression of AGT protein

NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977

G

calcium voltage-gated channel subunit alpha1 I

affects response to substance

CACNA1I protein affects the susceptibility to Thiopental

NCBI chr 7:111,835,996...111,947,418
Ensembl chr 7:111,836,012...111,944,688

G

caspase 3

increases activity
multiple interactions

Thiopental results in increased activity of CASP3 protein
Thiopental inhibits the reaction [Staurosporine results in increased activity of CASP3 protein]

PMID:16129983 PMID:18218830

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

cholinergic receptor, muscarinic 3

multiple interactions

Thiopental binds to and results in decreased activity of CHRM3 protein; Thiopental inhibits the reaction [Scopolamine Derivatives binds to CHRM3 protein]

NCBI chr17:60,005,137...60,467,250
Ensembl chr17:60,005,202...60,467,278

G

component of inhibitor of nuclear factor kappa B kinase complex

multiple interactions

Thiopental affects the reaction [TNF protein results in increased activity of CHUK protein]

NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065

G

glutamate ionotropic receptor AMPA type subunit 2

affects response to substance

GRIA2 protein affects the susceptibility to Thiopental

NCBI chr 2:165,949,379...166,069,510
Ensembl chr 2:165,947,521...166,069,510

G

heat shock transcription factor 1

increases phosphorylation
increases activity

Thiopental results in increased phosphorylation of HSF1 protein
Thiopental results in increased activity of HSF1 protein

NCBI chr 7:108,196,040...108,223,011
Ensembl chr 7:108,196,056...108,223,011

G

heat shock protein 90 alpha family class A member 1

increases expression

Thiopental results in increased expression of HSP90AA1 mRNA

NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268

G

heat shock protein family B (small) member 1

increases expression

Thiopental results in increased expression of HSPB1 mRNA

NCBI chr12:20,794,014...20,795,675
Ensembl chr12:20,794,028...20,795,743

G

interleukin 1 beta

multiple interactions

Thiopental promotes the reaction [IL1B protein results in increased abundance of Nitrites]; Thiopental promotes the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Thiopental promotes the reaction [IL1B protein results in increased expression of NOS2 protein]

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 2 receptor subunit alpha

decreases secretion

Thiopental results in decreased secretion of IL2RA protein

NCBI chr17:66,849,974...66,898,665
Ensembl chr17:66,849,974...66,898,697

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions

Thiopental inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of JUN mRNA]

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

NFKB inhibitor alpha

decreases degradation
multiple interactions

Thiopental results in decreased degradation of NFKBIA protein
TNF protein affects the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Thiopental] affects the phosphorylation of NFKBIA protein]

NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941

G

nerve growth factor

multiple interactions

Bicuculline inhibits the reaction [Thiopental inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein]]; Thiopental inhibits the reaction [Vincristine results in decreased susceptibility to NGF protein]

NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452

G

nitric oxide synthase 2

multiple interactions

Thiopental promotes the reaction [IL1B protein results in increased expression of NOS2 mRNA]; Thiopental promotes the reaction [IL1B protein results in increased expression of NOS2 protein]

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

neuropeptide Y

multiple interactions

Thiopental inhibits the reaction [Kainic Acid results in increased expression of NPY mRNA]

NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495

G

proenkephalin

multiple interactions

Thiopental inhibits the reaction [Kainic Acid results in increased expression of PENK mRNA]

NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129

G

protein tyrosine kinase 2

multiple interactions
increases phosphorylation

bisindolylmaleimide I inhibits the reaction [Thiopental results in increased phosphorylation of PTK2 protein]; bisindolylmaleimide IX inhibits the reaction [Thiopental results in increased phosphorylation of PTK2 protein]; chelerythrine inhibits the reaction [Thiopental results in increased phosphorylation of PTK2 protein]; Thiopental affects the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased phosphorylation of PTK2 protein]

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

surfactant protein C

increases expression

Thiopental results in increased expression of SFTPC mRNA

NCBI chr15:45,596,565...45,599,615
Ensembl chr15:45,596,574...45,610,777

G

tumor necrosis factor

multiple interactions

Thiopental affects the reaction [TNF protein results in increased activity of CHUK protein]; TNF protein affects the reaction [[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Thiopental] affects the phosphorylation of NFKBIA protein]

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19874
role	19844
application	19689
reagent	18051
2-thiobarbituric acid	20
thiopental	20
Path 2
Term	Annotations
CHEBI ontology	19874
subatomic particle	19872
composite particle	19872
hadron	19872
baryon	19872
nucleon	19872
atomic nucleus	19872
atom	19872
main group element atom	19811
p-block element atom	19811
carbon group element atom	19751
carbon atom	19748
organic molecular entity	19748
organic molecule	19700
organic cyclic compound	19490
organic heterocyclic compound	18868
organic heteromonocyclic compound	17791
diazines	13215
pyrimidines	13085
pyrimidone	10512
barbiturates	4627
2-thiobarbituric acid	20
thiopental	20

paths to the root