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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:2-nitrotoluene
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Accession:CHEBI:33098 term browser browse the term
Definition:A mononitrotoluene that is toluene carrying a nitro substituent at position 2.
Synonyms:related_synonym: 2-Nitrotoluol;   2-methyl-1-nitrobenzene;   Formula=C7H7NO2;   InChI=1S/C7H7NO2/c1-6-4-2-3-5-7(6)8(9)10/h2-5H,1H3;   InChIKey=PLAZTCDQAHEYBI-UHFFFAOYSA-N;   ONT;   SMILES=Cc1ccccc1[N+]([O-])=O;   o-Nitrotoluol;   o-methylnitrobenzene;   o-nitrotoluene;   ortho-Nitrotoluol
 xref: CAS:88-72-2;   KEGG:C19597
 xref_mesh: MESH:C029955
 xref: MetaCyc:2-NITROTOLUENE;   PMID:20582618;   PMID:21432561;   PMID:23153775;   PMID:7944378;   Reaxys:1907580;   Wikipedia:2-Nitrotoluene



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2-nitrotoluene term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actg2 actin gamma 2, smooth muscle decreases expression EXP 2-nitrotoluene results in decreased expression of ACTG2 mRNA CTD PMID:16460773 NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465
JBrowse link
G Actn1 actinin, alpha 1 decreases expression EXP 2-nitrotoluene results in decreased expression of ACTN1 mRNA CTD PMID:16460773 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
JBrowse link
G Actn4 actinin alpha 4 decreases expression EXP 2-nitrotoluene results in decreased expression of ACTN4 mRNA CTD PMID:16460773 NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847
JBrowse link
G Akap10 A-kinase anchoring protein 10 decreases expression ISO 2-nitrotoluene results in decreased expression of AKAP10 mRNA CTD PMID:15612046 NCBI chr10:46,545,464...46,608,768
Ensembl chr10:46,551,532...46,608,769
JBrowse link
G Akt2 AKT serine/threonine kinase 2 increases expression EXP 2-nitrotoluene results in increased expression of AKT2 mRNA CTD PMID:16460773 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Arf4 ADP-ribosylation factor 4 decreases expression EXP 2-nitrotoluene results in decreased expression of ARF4 mRNA CTD PMID:16460773 NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261
JBrowse link
G Arid3a AT-rich interaction domain 3A increases expression ISO 2-nitrotoluene results in increased expression of ARID3A mRNA CTD PMID:15612046 NCBI chr 7:9,755,291...9,781,260
Ensembl chr 7:9,755,294...9,780,599
JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression EXP 2-nitrotoluene results in increased expression of BNIP3L mRNA CTD PMID:16460773 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G Ccn3 cellular communication network factor 3 decreases expression EXP 2-nitrotoluene results in decreased expression of CCN3 mRNA CTD PMID:16460773 NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019
JBrowse link
G Ccng1 cyclin G1 increases expression ISO 2-nitrotoluene results in increased expression of CCNG1 mRNA CTD PMID:15618236 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression
increases expression
EXP
ISO
2-nitrotoluene results in decreased expression of CDKN1A mRNA
2-nitrotoluene results in increased expression of CDKN1A mRNA
CTD PMID:15618236 PMID:16460773 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cish cytokine inducible SH2-containing protein decreases expression ISO 2-nitrotoluene results in decreased expression of CISH mRNA CTD PMID:15618236 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
JBrowse link
G Col1a2 collagen type I alpha 2 chain decreases expression EXP 2-nitrotoluene results in decreased expression of COL1A2 mRNA CTD PMID:16460773 NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
JBrowse link
G Ctnnb1 catenin beta 1 increases mutagenesis ISO 2-nitrotoluene results in increased mutagenesis of CTNNB1 gene CTD PMID:13678655 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO 2-nitrotoluene results in increased expression of CYP2B10 mRNA CTD PMID:15618236 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Ecm1 extracellular matrix protein 1 decreases expression ISO 2-nitrotoluene results in decreased expression of ECM1 mRNA CTD PMID:15612046 NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671
JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO 2-nitrotoluene results in decreased expression of EGFR mRNA CTD PMID:15618236 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Fas Fas cell surface death receptor decreases expression EXP 2-nitrotoluene results in decreased expression of FAS mRNA CTD PMID:16460773 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fat1 FAT atypical cadherin 1 decreases expression EXP 2-nitrotoluene results in decreased expression of FAT1 mRNA CTD PMID:16460773 NCBI chr16:47,177,253...47,296,261
Ensembl chr16:47,177,248...47,296,107
JBrowse link
G Fgfrl1 fibroblast growth factor receptor-like 1 decreases expression ISO 2-nitrotoluene results in decreased expression of FGFRL1 protein CTD PMID:22434383 NCBI chr14:1,009,863...1,022,620
Ensembl chr14:1,009,786...1,021,928
JBrowse link
G Fhit fragile histidine triad diadenosine triphosphatase decreases expression ISO 2-nitrotoluene results in decreased expression of FHIT mRNA; 2-nitrotoluene results in decreased expression of FHIT protein CTD PMID:15618236 NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression EXP 2-nitrotoluene results in decreased expression of FOS mRNA CTD PMID:16460773 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Fosl1 FOS like 1, AP-1 transcription factor subunit decreases expression EXP 2-nitrotoluene results in decreased expression of FOSL1 mRNA CTD PMID:16460773 NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
JBrowse link
G Fzd2 frizzled class receptor 2 decreases expression EXP 2-nitrotoluene results in decreased expression of FZD2 mRNA CTD PMID:16460773 NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression EXP 2-nitrotoluene results in decreased expression of GADD45A mRNA CTD PMID:16460773 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gadd45b growth arrest and DNA-damage-inducible, beta increases expression ISO 2-nitrotoluene results in increased expression of GADD45B mRNA CTD PMID:15618236 NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
JBrowse link
G Gnaq G protein subunit alpha q decreases expression EXP 2-nitrotoluene results in decreased expression of GNAQ mRNA CTD PMID:16460773 NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta affects expression EXP 2-nitrotoluene affects the expression of GSK3B mRNA CTD PMID:16460773 NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gtf2ird1 GTF2I repeat domain containing 1 decreases expression ISO 2-nitrotoluene results in decreased expression of GTF2IRD1 protein CTD PMID:22434383 NCBI chr12:22,254,113...22,361,052
Ensembl chr12:22,254,221...22,361,040
JBrowse link
G Igf1 insulin-like growth factor 1 increases expression EXP 2-nitrotoluene results in increased expression of IGF1 mRNA CTD PMID:16460773 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igfbp2 insulin-like growth factor binding protein 2 increases expression EXP 2-nitrotoluene results in increased expression of IGFBP2 mRNA CTD PMID:16460773 NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 increases expression EXP 2-nitrotoluene results in increased expression of IGFBP3 mRNA CTD PMID:16460773 NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
JBrowse link
G Igfbp6 insulin-like growth factor binding protein 6 increases expression EXP 2-nitrotoluene results in increased expression of IGFBP6 mRNA CTD PMID:16460773 NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966
JBrowse link
G Il7 interleukin 7 increases expression ISO 2-nitrotoluene results in increased expression of IL7 mRNA CTD PMID:15612046 NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
JBrowse link
G Ilk integrin-linked kinase decreases expression EXP 2-nitrotoluene results in decreased expression of ILK mRNA CTD PMID:16460773 NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
JBrowse link
G Inhba inhibin subunit beta A decreases expression ISO 2-nitrotoluene results in decreased expression of INHBA mRNA CTD PMID:15618236 NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
JBrowse link
G Itga8 integrin subunit alpha 8 decreases expression EXP 2-nitrotoluene results in decreased expression of ITGA8 mRNA CTD PMID:16460773 NCBI chr17:75,304,004...75,501,510
Ensembl chr17:75,304,008...75,501,510
JBrowse link
G Itgb1 integrin subunit beta 1 decreases expression EXP 2-nitrotoluene results in decreased expression of ITGB1 mRNA CTD PMID:16460773 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Itgb2 integrin subunit beta 2 increases expression EXP 2-nitrotoluene results in increased expression of ITGB2 mRNA CTD PMID:16460773 NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
JBrowse link
G Krt10 keratin 10 decreases expression ISO 2-nitrotoluene results in decreased expression of KRT10 protein CTD PMID:22434383 NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701
JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO 2-nitrotoluene results in decreased expression of LEF1 mRNA CTD PMID:15612046 NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
JBrowse link
G Mapkapk2 MAPK activated protein kinase 2 increases expression EXP 2-nitrotoluene results in increased expression of MAPKAPK2 mRNA CTD PMID:16460773 NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
JBrowse link
G Msln mesothelin increases expression EXP 2-nitrotoluene results in increased expression of MSLN mRNA CTD PMID:16460773 NCBI chr10:14,771,946...14,781,382
Ensembl chr10:14,771,961...14,777,643
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression EXP 2-nitrotoluene results in increased expression of MYC mRNA CTD PMID:16460773 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Nras NRAS proto-oncogene, GTPase increases expression EXP 2-nitrotoluene results in increased expression of NRAS mRNA CTD PMID:16460773 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
JBrowse link
G Pard3 par-3 family cell polarity regulator increases expression ISO 2-nitrotoluene results in increased expression of PARD3 protein CTD PMID:22434383 NCBI chr19:55,080,282...55,630,111
Ensembl chr19:55,080,282...55,629,778
JBrowse link
G Pld3 phospholipase D family, member 3 increases expression ISO 2-nitrotoluene results in increased expression of PLD3 mRNA CTD PMID:15612046 NCBI chr 1:82,821,863...82,844,280
Ensembl chr 1:82,821,875...82,844,072
JBrowse link
G Ppp1r12a protein phosphatase 1, regulatory subunit 12A decreases expression EXP 2-nitrotoluene results in decreased expression of PPP1R12A mRNA CTD PMID:16460773 NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
JBrowse link
G Ppp2r2b protein phosphatase 2, regulatory subunit B, beta increases expression EXP 2-nitrotoluene results in increased expression of PPP2R2B mRNA CTD PMID:16460773 NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025
JBrowse link
G Prkcz protein kinase C, zeta increases expression EXP 2-nitrotoluene results in increased expression of PRKCZ mRNA CTD PMID:16460773 NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
JBrowse link
G Rad18 RAD18 E3 ubiquitin protein ligase decreases expression ISO 2-nitrotoluene results in decreased expression of RAD18 protein CTD PMID:22434383 NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069
JBrowse link
G Rala RAS like proto-oncogene A decreases expression EXP 2-nitrotoluene results in decreased expression of RALA mRNA CTD PMID:16460773 NCBI chr17:47,092,139...47,145,192
Ensembl chr17:47,092,207...47,144,063
JBrowse link
G S100a4 S100 calcium-binding protein A4 increases expression ISO 2-nitrotoluene results in increased expression of S100A4 mRNA CTD PMID:15612046 NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
JBrowse link
G Slc9a3r1 SLC9A3 regulator 1 increases expression ISO 2-nitrotoluene results in increased expression of SLC9A3R1 protein CTD PMID:22434383 NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598
JBrowse link
G St7l suppression of tumorigenicity 7-like decreases expression ISO 2-nitrotoluene results in decreased expression of ST7L mRNA CTD PMID:15612046 NCBI chr 2:192,364,594...192,434,414
Ensembl chr 2:192,364,594...192,487,190
JBrowse link
G Stat5b signal transducer and activator of transcription 5B decreases activity ISO 2-nitrotoluene results in decreased activity of STAT5B protein CTD PMID:30114225 NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
JBrowse link
G Tgfb2 transforming growth factor, beta 2 decreases expression EXP 2-nitrotoluene results in decreased expression of TGFB2 mRNA CTD PMID:16460773 NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
JBrowse link
G Tgfb3 transforming growth factor, beta 3 decreases expression EXP 2-nitrotoluene results in decreased expression of TGFB3 mRNA CTD PMID:16460773 NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
JBrowse link
G Tgfbr2 transforming growth factor, beta receptor 2 increases expression EXP 2-nitrotoluene results in increased expression of TGFBR2 mRNA CTD PMID:16460773 NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
JBrowse link
G Tp53 tumor protein p53 increases mutagenesis ISO 2-nitrotoluene results in increased mutagenesis of TRP53 gene CTD PMID:13678655 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Tph1 tryptophan hydroxylase 1 increases expression ISO 2-nitrotoluene results in increased expression of TPH1 mRNA CTD PMID:15612046 NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
JBrowse link
G Wnt4 Wnt family member 4 increases expression EXP 2-nitrotoluene results in increased expression of WNT4 mRNA CTD PMID:16460773 NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859
JBrowse link
G Wwox WW domain-containing oxidoreductase decreases expression ISO 2-nitrotoluene results in decreased expression of WWOX mRNA; 2-nitrotoluene results in decreased expression of WWOX protein CTD PMID:15618236 NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391
JBrowse link

Term paths to the root
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  CHEBI ontology 20050
    role 20001
      chemical role 19530
        environmental contaminant 18801
          2-nitrotoluene 63
Path 2
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  CHEBI ontology 20050
    subatomic particle 20048
      composite particle 20048
        hadron 20048
          baryon 20048
            nucleon 20048
              atomic nucleus 20048
                atom 20048
                  main group element atom 19948
                    p-block element atom 19948
                      carbon group element atom 19872
                        carbon atom 19863
                          organic molecular entity 19863
                            organic molecule 19809
                              organic cyclic compound 19572
                                carbocyclic compound 18516
                                  benzenoid aromatic compound 17764
                                    benzenes 17567
                                      toluenes 6312
                                        nitrotoluene 3886
                                          mononitrotoluene 68
                                            2-nitrotoluene 63
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