CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 2-nitrotoluene
Accession: CHEBI:33098
browse the term
Definition: A mononitrotoluene that is toluene carrying a nitro substituent at position 2.
Synonyms: related_synonym: 2-Nitrotoluol; 2-methyl-1-nitrobenzene; Formula=C7H7NO2; InChI=1S/C7H7NO2/c1-6-4-2-3-5-7(6)8(9)10/h2-5H,1H3; InChIKey=PLAZTCDQAHEYBI-UHFFFAOYSA-N; ONT; SMILES=Cc1ccccc1[N+]([O-])=O; o-Nitrotoluol; o-methylnitrobenzene; o-nitrotoluene; ortho-Nitrotoluol
xref: CAS:88-72-2; KEGG:C19597
xref_mesh: MESH:C029955
xref: MetaCyc:2-NITROTOLUENE; PMID:20582618; PMID:21432561; PMID:23153775; PMID:7944378; Reaxys:1907580; Wikipedia:2-Nitrotoluene
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Actg2
actin gamma 2, smooth muscle
decreases expression
EXP
2-nitrotoluene results in decreased expression of ACTG2 mRNA
CTD
PMID:16460773
NCBI chr 4:116,021,832...116,046,475
Ensembl chr 4:116,021,832...116,046,465
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Actn1
actinin, alpha 1
decreases expression
EXP
2-nitrotoluene results in decreased expression of ACTN1 mRNA
CTD
PMID:16460773
NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
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Actn4
actinin alpha 4
decreases expression
EXP
2-nitrotoluene results in decreased expression of ACTN4 mRNA
CTD
PMID:16460773
NCBI chr 1:84,182,783...84,251,867
Ensembl chr 1:84,182,788...84,251,847
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Akap10
A-kinase anchoring protein 10
decreases expression
ISO
2-nitrotoluene results in decreased expression of AKAP10 mRNA
CTD
PMID:15612046
NCBI chr10:46,545,371...46,608,730
Ensembl chr10:46,551,532...46,608,769
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Akt2
AKT serine/threonine kinase 2
increases expression
EXP
2-nitrotoluene results in increased expression of AKT2 mRNA
CTD
PMID:16460773
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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Arf4
ADP-ribosylation factor 4
decreases expression
EXP
2-nitrotoluene results in decreased expression of ARF4 mRNA
CTD
PMID:16460773
NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261
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Arid3a
AT-rich interaction domain 3A
increases expression
ISO
2-nitrotoluene results in increased expression of ARID3A mRNA
CTD
PMID:15612046
NCBI chr 7:9,755,291...9,781,260
Ensembl chr 7:9,755,294...9,780,599
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Bnip3l
BCL2 interacting protein 3 like
increases expression
EXP
2-nitrotoluene results in increased expression of BNIP3L mRNA
CTD
PMID:16460773
NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
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Ccn3
cellular communication network factor 3
decreases expression
EXP
2-nitrotoluene results in decreased expression of CCN3 mRNA
CTD
PMID:16460773
NCBI chr 7:86,094,000...86,101,022
Ensembl chr 7:86,094,000...86,101,019
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Ccng1
cyclin G1
increases expression
ISO
2-nitrotoluene results in increased expression of CCNG1 mRNA
CTD
PMID:15618236
NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
decreases expression increases expression
EXP ISO
2-nitrotoluene results in decreased expression of CDKN1A mRNA 2-nitrotoluene results in increased expression of CDKN1A mRNA
CTD
PMID:15618236 PMID:16460773
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cish
cytokine inducible SH2-containing protein
decreases expression
ISO
2-nitrotoluene results in decreased expression of CISH mRNA
CTD
PMID:15618236
NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
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Col1a2
collagen type I alpha 2 chain
decreases expression
EXP
2-nitrotoluene results in decreased expression of COL1A2 mRNA
CTD
PMID:16460773
NCBI chr 4:32,563,938...32,598,868
Ensembl chr 4:32,563,381...32,598,867
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Ctnnb1
catenin beta 1
increases mutagenesis
ISO
2-nitrotoluene results in increased mutagenesis of CTNNB1 gene
CTD
PMID:13678655
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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Cyp2b3
cytochrome P450, family 2, subfamily b, polypeptide 3
increases expression
ISO
2-nitrotoluene results in increased expression of CYP2B10 mRNA
CTD
PMID:15618236
NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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Ecm1
extracellular matrix protein 1
decreases expression
ISO
2-nitrotoluene results in decreased expression of ECM1 mRNA
CTD
PMID:15612046
NCBI chr 2:183,287,491...183,292,729
Ensembl chr 2:183,287,322...183,292,671
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Egfr
epidermal growth factor receptor
decreases expression
ISO
2-nitrotoluene results in decreased expression of EGFR mRNA
CTD
PMID:15618236
NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382
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Fas
Fas cell surface death receptor
decreases expression
EXP
2-nitrotoluene results in decreased expression of FAS mRNA
CTD
PMID:16460773
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Fat1
FAT atypical cadherin 1
decreases expression
EXP
2-nitrotoluene results in decreased expression of FAT1 mRNA
CTD
PMID:16460773
NCBI chr16:47,177,253...47,296,261
Ensembl chr16:47,177,248...47,296,107
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Fgfrl1
fibroblast growth factor receptor-like 1
decreases expression
ISO
2-nitrotoluene results in decreased expression of FGFRL1 protein
CTD
PMID:22434383
NCBI chr14:1,009,863...1,022,620
Ensembl chr14:1,009,786...1,021,928
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Fhit
fragile histidine triad diadenosine triphosphatase
decreases expression
ISO
2-nitrotoluene results in decreased expression of FHIT mRNA; 2-nitrotoluene results in decreased expression of FHIT protein
CTD
PMID:15618236
NCBI chr15:13,935,029...15,442,620
Ensembl chr15:13,934,995...15,442,340
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
decreases expression
EXP
2-nitrotoluene results in decreased expression of FOS mRNA
CTD
PMID:16460773
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Fosl1
FOS like 1, AP-1 transcription factor subunit
decreases expression
EXP
2-nitrotoluene results in decreased expression of FOSL1 mRNA
CTD
PMID:16460773
NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930
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Fzd2
frizzled class receptor 2
decreases expression
EXP
2-nitrotoluene results in decreased expression of FZD2 mRNA
CTD
PMID:16460773
NCBI chr10:87,561,866...87,563,776
Ensembl chr10:87,561,326...87,565,334
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Gadd45a
growth arrest and DNA-damage-inducible, alpha
decreases expression
EXP
2-nitrotoluene results in decreased expression of GADD45A mRNA
CTD
PMID:16460773
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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Gadd45b
growth arrest and DNA-damage-inducible, beta
increases expression
ISO
2-nitrotoluene results in increased expression of GADD45B mRNA
CTD
PMID:15618236
NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046
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Gnaq
G protein subunit alpha q
decreases expression
EXP
2-nitrotoluene results in decreased expression of GNAQ mRNA
CTD
PMID:16460773
NCBI chr 1:213,425,631...213,671,947
Ensembl chr 1:213,424,465...213,667,672
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Gsk3b
glycogen synthase kinase 3 beta
affects expression
EXP
2-nitrotoluene affects the expression of GSK3B mRNA
CTD
PMID:16460773
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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Gtf2ird1
GTF2I repeat domain containing 1
decreases expression
ISO
2-nitrotoluene results in decreased expression of GTF2IRD1 protein
CTD
PMID:22434383
NCBI chr12:22,254,113...22,361,052
Ensembl chr12:22,254,221...22,361,040
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Igf1
insulin-like growth factor 1
increases expression
EXP
2-nitrotoluene results in increased expression of IGF1 mRNA
CTD
PMID:16460773
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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Igfbp2
insulin-like growth factor binding protein 2
increases expression
EXP
2-nitrotoluene results in increased expression of IGFBP2 mRNA
CTD
PMID:16460773
NCBI chr 9:74,415,574...74,442,945
Ensembl chr 9:74,415,546...74,442,937
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Igfbp3
insulin-like growth factor binding protein 3
increases expression
EXP
2-nitrotoluene results in increased expression of IGFBP3 mRNA
CTD
PMID:16460773
NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
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Igfbp6
insulin-like growth factor binding protein 6
increases expression
EXP
2-nitrotoluene results in increased expression of IGFBP6 mRNA
CTD
PMID:16460773
NCBI chr 7:133,276,309...133,280,944
Ensembl chr 7:133,276,234...133,280,966
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Il7
interleukin 7
increases expression
ISO
2-nitrotoluene results in increased expression of IL7 mRNA
CTD
PMID:15612046
NCBI chr 2:94,235,219...94,280,075
Ensembl chr 2:94,234,766...94,280,075
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Ilk
integrin-linked kinase
decreases expression
EXP
2-nitrotoluene results in decreased expression of ILK mRNA
CTD
PMID:16460773
NCBI chr 1:160,088,839...160,095,140
Ensembl chr 1:160,088,897...160,095,140
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Inhba
inhibin subunit beta A
decreases expression
ISO
2-nitrotoluene results in decreased expression of INHBA mRNA
CTD
PMID:15618236
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
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Itga8
integrin subunit alpha 8
decreases expression
EXP
2-nitrotoluene results in decreased expression of ITGA8 mRNA
CTD
PMID:16460773
NCBI chr17:75,304,004...75,501,510
Ensembl chr17:75,304,008...75,501,510
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Itgb1
integrin subunit beta 1
decreases expression
EXP
2-nitrotoluene results in decreased expression of ITGB1 mRNA
CTD
PMID:16460773
NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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Itgb2
integrin subunit beta 2
increases expression
EXP
2-nitrotoluene results in increased expression of ITGB2 mRNA
CTD
PMID:16460773
NCBI chr20:11,061,394...11,097,656
Ensembl chr20:11,061,430...11,097,600
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Krt10
keratin 10
decreases expression
ISO
2-nitrotoluene results in decreased expression of KRT10 protein
CTD
PMID:22434383
NCBI chr10:84,338,695...84,343,279
Ensembl chr10:84,338,706...84,343,701
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Lef1
lymphoid enhancer binding factor 1
decreases expression
ISO
2-nitrotoluene results in decreased expression of LEF1 mRNA
CTD
PMID:15612046
NCBI chr 2:219,666,549...219,779,815
Ensembl chr 2:219,666,592...219,779,794
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Mapkapk2
MAPK activated protein kinase 2
increases expression
EXP
2-nitrotoluene results in increased expression of MAPKAPK2 mRNA
CTD
PMID:16460773
NCBI chr13:42,513,762...42,560,061
Ensembl chr13:42,513,762...42,560,457
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Msln
mesothelin
increases expression
EXP
2-nitrotoluene results in increased expression of MSLN mRNA
CTD
PMID:16460773
NCBI chr10:14,771,946...14,781,382
Ensembl chr10:14,771,961...14,777,643
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Myc
MYC proto-oncogene, bHLH transcription factor
increases expression
EXP
2-nitrotoluene results in increased expression of MYC mRNA
CTD
PMID:16460773
NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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Nherf1
NHERF family PDZ scaffold protein 1
increases expression
ISO
2-nitrotoluene results in increased expression of NHERF1 protein
CTD
PMID:22434383
NCBI chr10:100,403,189...100,420,290
Ensembl chr10:100,403,069...100,420,598
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Nras
NRAS proto-oncogene, GTPase
increases expression
EXP
2-nitrotoluene results in increased expression of NRAS mRNA
CTD
PMID:16460773
NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
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Pard3
par-3 family cell polarity regulator
increases expression
ISO
2-nitrotoluene results in increased expression of PARD3 protein
CTD
PMID:22434383
NCBI chr19:55,080,282...55,630,111
Ensembl chr19:55,080,282...55,629,778
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Pld3
phospholipase D family, member 3
increases expression
ISO
2-nitrotoluene results in increased expression of PLD3 mRNA
CTD
PMID:15612046
NCBI chr 1:82,821,863...82,844,280
Ensembl chr 1:82,821,875...82,844,072
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Ppp1r12a
protein phosphatase 1, regulatory subunit 12A
decreases expression
EXP
2-nitrotoluene results in decreased expression of PPP1R12A mRNA
CTD
PMID:16460773
NCBI chr 7:43,482,808...43,593,689
Ensembl chr 7:43,482,803...43,593,425
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Ppp2r2b
protein phosphatase 2, regulatory subunit B, beta
increases expression
EXP
2-nitrotoluene results in increased expression of PPP2R2B mRNA
CTD
PMID:16460773
NCBI chr18:34,653,716...35,080,889
Ensembl chr18:34,653,721...35,081,025
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Prkcz
protein kinase C, zeta
increases expression
EXP
2-nitrotoluene results in increased expression of PRKCZ mRNA
CTD
PMID:16460773
NCBI chr 5:165,817,786...165,930,386
Ensembl chr 5:165,819,466...165,930,367
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Rad18
RAD18 E3 ubiquitin protein ligase
decreases expression
ISO
2-nitrotoluene results in decreased expression of RAD18 protein
CTD
PMID:22434383
NCBI chr 4:145,735,654...145,821,102
Ensembl chr 4:145,735,654...145,821,069
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Rala
RAS like proto-oncogene A
decreases expression
EXP
2-nitrotoluene results in decreased expression of RALA mRNA
CTD
PMID:16460773
NCBI chr17:47,092,163...47,145,192
Ensembl chr17:47,092,207...47,144,063
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S100a4
S100 calcium-binding protein A4
increases expression
ISO
2-nitrotoluene results in increased expression of S100A4 mRNA
CTD
PMID:15612046
NCBI chr 2:176,090,951...176,093,258
Ensembl chr 2:176,091,804...176,093,254
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St7l
suppression of tumorigenicity 7-like
decreases expression
ISO
2-nitrotoluene results in decreased expression of ST7L mRNA
CTD
PMID:15612046
NCBI chr 2:192,364,594...192,434,414
Ensembl chr 2:192,364,594...192,487,190
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Stat5b
signal transducer and activator of transcription 5B
decreases activity
ISO
2-nitrotoluene results in decreased activity of STAT5B protein
CTD
PMID:30114225
NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668
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Tgfb2
transforming growth factor, beta 2
decreases expression
EXP
2-nitrotoluene results in decreased expression of TGFB2 mRNA
CTD
PMID:16460773
NCBI chr13:98,160,075...98,261,771
Ensembl chr13:98,160,087...98,261,405
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Tgfb3
transforming growth factor, beta 3
decreases expression
EXP
2-nitrotoluene results in decreased expression of TGFB3 mRNA
CTD
PMID:16460773
NCBI chr 6:105,704,058...105,726,661
Ensembl chr 6:105,704,236...105,726,564
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Tgfbr2
transforming growth factor, beta receptor 2
increases expression
EXP
2-nitrotoluene results in increased expression of TGFBR2 mRNA
CTD
PMID:16460773
NCBI chr 8:115,794,537...115,883,615
Ensembl chr 8:115,794,537...115,883,228
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Tp53
tumor protein p53
increases mutagenesis
ISO
2-nitrotoluene results in increased mutagenesis of TRP53 gene
CTD
PMID:13678655
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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Tph1
tryptophan hydroxylase 1
increases expression
ISO
2-nitrotoluene results in increased expression of TPH1 mRNA
CTD
PMID:15612046
NCBI chr 1:97,157,375...97,178,415
Ensembl chr 1:97,157,409...97,178,344
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Wnt4
Wnt family member 4
increases expression
EXP
2-nitrotoluene results in increased expression of WNT4 mRNA
CTD
PMID:16460773
NCBI chr 5:149,513,573...149,535,415
Ensembl chr 5:149,514,018...149,532,859
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Wwox
WW domain-containing oxidoreductase
decreases expression
ISO
2-nitrotoluene results in decreased expression of WWOX mRNA; 2-nitrotoluene results in decreased expression of WWOX protein
CTD
PMID:15618236
NCBI chr19:42,432,141...43,360,278
Ensembl chr19:42,432,152...43,359,391
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